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Vitamin D and NLRP3


1,25(OH)2 D3 alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation.
Cao R, Ma Y, Li S, Shen D, Yang S, Wang X, Cao Y, Wang Z, Wei Y, Li S, Liu G, Zhang H, Wang Y, Ma Y.
J Leukoc Biol. 2020 Apr 1. doi: 10.1002/JLB.3MA0320-406RR. [Epub ahead of print]

Calcitriol Prevents Neuroinflammation and Reduces Blood-Brain Barrier Disruption and Local Macrophage/Microglia Activation.
de Oliveira LRC, Mimura LAN, Fraga-Silva TFC, Ishikawa LLW, Fernandes AAH, Zorzella-Pezavento SFG, Sartori A.
Front Pharmacol. 2020 Mar 12;11:161. doi: 10.3389/fphar.2020.00161. eCollection 2020.

Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination.
Rao Z, Chen X, Wu J, Xiao M, Zhang J, Wang B, Fang L, Zhang H, Wang X, Yang S, Chen Y.
Front Immunol. 2019 Dec 4;10:2783. doi: 10.3389/fimmu.2019.02783. eCollection 2019.

Toxicity of cooking oil fume derived particulate matter: Vitamin D3 protects tubule formation activation in human umbilical vein endothelial cells.
Ding L, Sui X, Yang M, Zhang Q, Sun S, Zhu F, Cheng H, Zhang C, Chen H, Ding R, Cao J.
Ecotoxicol Environ Saf. 2020 Jan 30;188:109905. doi: 10.1016/j.ecoenv.2019.109905. Epub 2019 Nov 6.

Effects of 1,25-dihydroxyvitamin D3 on experimental periodontitis and AhR/NF-κB/NLRP3inflammasome pathway in a mouse model.
Li H, Zhong X, Li W, Wang Q.
J Appl Oral Sci. 2019 Nov 4;27:e20180713. doi: 10.1590/1678-7757-2018-0713. eCollection 2019.

Vitamin D insufficiency increases risk of chronic pain among African Americans experiencing motor vehicle collision.
Mauck MC, Linnstaedt SD, Bortsov A, Kurz M, Hendry PL, Lewandowski C, Velilla MA, Datner E, Pearson C, Domeier R, Fillingim RB, Beaudoin FL, Ting JP, McLean SA.
Pain. 2020 Feb;161(2):274-280. doi: 10.1097/j.pain.0000000000001728.

Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells.
Dai Y, Zhang J, Xiang J, Li Y, Wu D, Xu J.
Redox Biol. 2019 Feb;21:101093. doi: 10.1016/j.redox.2018.101093. Epub 2018 Dec 26.

1,25-Dihydroxy Vitamin D3 Attenuates the Oxidative Stress-Mediated Inflammation Induced by PM2.5via the p38/NF-κB/NLRP3 Pathway.
Xin L, Che B, Zhai B, Luo Q, Zhang C, Wang J, Wang S, Fan G, Liu Z, Feng J, Zhang Z.
Inflammation. 2019 Apr;42(2):702-713. doi: 10.1007/s10753-018-0928-y.

Paricalcitol attenuates TGF-β1-induced phenotype transition of human peritoneal mesothelial cells (HPMCs) via modulation of oxidative stress and NLRP3 inflammasome.
Ko J, Kang HJ, Kim DA, Ryu ES, Yu M, Lee H, Lee HK, Ryu HM, Park SH, Kim YL, Kang DH.
FASEB J. 2019 Feb;33(2):3035-3050. doi: 10.1096/fj.201800292RR. Epub 2018 Oct 24.

Vitamin D receptor interacts with NLRP3 to restrict the allergic response.
Huang H, Hong JY, Wu YJ, Wang EY, Liu ZQ, Cheng BH, Mei L, Liu ZG, Yang PC, Zheng PY.
Clin Exp Immunol. 2018 Oct;194(1):17-26. doi: 10.1111/cei.13164. Epub 2018 Sep 9.

Vitamin D3 Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROS/TXNIP/NLRP3 Inflammasome Pathway.
Lu L, Lu Q, Chen W, Li J, Li C, Zheng Z.
J Diabetes Res. 2018 Feb 22;2018:8193523. doi: 10.1155/2018/8193523. eCollection 2018.

The Effects of Varying Degree of MWCNT Carboxylation on Bioactivity in Various In Vivo and In Vitro Exposure Models.
Hamilton RF, Wu Z, Mitra S, Holian A.
Int J Mol Sci. 2018 Jan 25;19(2). pii: E354. doi: 10.3390/ijms19020354.

Vitamin D3 levels and NLRP3 expression in murine models of obese asthma: association with asthma outcomes.
Zhang JH, Chen YP, Yang X, Li CQ.
Braz J Med Biol Res. 2017 Nov 13;51(1):e6841. doi: 10.1590/1414-431X20176841.

Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome.
Ali NS, Sartori-Valinotti JC, Bruce AJ.
Clin Dermatol. 2016 Jul-Aug;34(4):482-6. doi: 10.1016/j.clindermatol.2016.02.021. Epub 2016 Mar 2. Review.

Phenylbutyrate Is Bacteriostatic against Mycobacterium tuberculosis and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D3.
Coussens AK, Wilkinson RJ, Martineau AR.
PLoS Pathog. 2015 Jul 2;11(7):e1005007. doi: 10.1371/journal.ppat.1005007. eCollection 2015 Jul.

Resveratrol alleviates vascular inflammatory injury by inhibiting inflammasome activation in rats with hypercholesterolemia and vitamin D2 treatment.
Deng ZY, Hu MM, Xin YF, Gang C.
Inflamm Res. 2015 May;64(5):321-32. doi: 10.1007/s00011-015-0810-4. Epub 2015 Apr 2.

Vitamin D₃ metabolites enhance the NLRP3-dependent secretion of IL-1β from human THP-1 monocytic cells.
Tulk SE, Liao KC, Muruve DA, Li Y, Beck PL, MacDonald JA.
J Cell Biochem. 2015 May;116(5):711-20. doi: 10.1002/jcb.24985.

Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis.
Peelen E, Damoiseaux J, Muris AH, Knippenberg S, Smolders J, Hupperts R, Thewissen M.
Mol Immunol. 2015 Feb;63(2):521-9.

Vitamin D induces interleukin-1β expression: paracrine macrophage epithelial signaling controls M. tuberculosis infection.
Verway M, Bouttier M, Wang TT, Carrier M, Calderon M, An BS, Devemy E, McIntosh F, Divangahi M, Behr MA, White JH.
PLoS Pathog. 2013;9(6):e1003407. doi: 10.1371/journal.ppat.1003407. Epub 2013 Jun 6.