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Diabetes and NLRP3 

Enhanced Inflammatory Reaction and Thrombosis in High-Fat Diet-Fed ApoE-/- Mice are Attenuated by Celastrol.
Ouyang M, Qin T, Liu H, Lu J, Peng C, Guo Q.
Exp Clin Endocrinol Diabetes. 2020 Mar 16. doi: 10.1055/a-1010-5543. [Epub ahead of print]

P2X7 receptor mediates NLRP3 inflammasome activation in depression and diabetes.
Wang D, Wang H, Gao H, Zhang H, Zhang H, Wang Q, Sun Z.
Cell Biosci. 2020 Mar 5;10:28. doi: 10.1186/s13578-020-00388-1. eCollection 2020. Review.

Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
Zhu Y, Zhu C, Yang H, Deng J, Fan D.
Pharmacol Res. 2020 Mar 7;155:104746. doi: 10.1016/j.phrs.2020.104746. [Epub ahead of print]

Salvianolic Acid A Ameliorates Early-Stage Atherosclerosis Development by Inhibiting NLRP3Inflammasome Activation in Zucker Diabetic Fatty Rats.
Ma Q, Yang Q, Chen J, Yu C, Zhang L, Zhou W, Chen M.
Molecules. 2020 Feb 28;25(5). pii: E1089. doi: 10.3390/molecules25051089.

Contribution of TGF-Beta-Mediated NLRP3-HMGB1 Activation to Tubulointerstitial Fibrosis in Rat With Angiotensin II-Induced Chronic Kidney Disease.
Zhang K, Fan C, Cai D, Zhang Y, Zuo R, Zhu L, Cao Y, Zhang J, Liu C, Chen Y, Liang H.
Front Cell Dev Biol. 2020 Feb 5;8:1. doi: 10.3389/fcell.2020.00001. eCollection 2020.

Silencing of KCNQ1OT1 Decreases Oxidative Stress and Pyroptosis of Renal Tubular Epithelial Cells.
Zhu B, Cheng X, Jiang Y, Cheng M, Chen L, Bao J, Tang X.
Diabetes Metab Syndr Obes. 2020 Feb 13;13:365-375. doi: 10.2147/DMSO.S225791. eCollection 2020.

Mesenchymal Stem Cells Attenuate Diabetic Lung Fibrosis via Adjusting Sirt3-Mediated Stress Responses in Rats.
Chen Y, Zhang F, Wang D, Li L, Si H, Wang C, Liu J, Chen Y, Cheng J, Lu Y.
Oxid Med Cell Longev. 2020 Feb 4;2020:8076105. doi: 10.1155/2020/8076105. eCollection 2020.

P2X4 receptor exacerbates ischemic AKI and induces renal proximal tubular NLRP3 inflammasome signaling.
Han SJ, Lovaszi M, Kim M, D’Agati V, Haskó G, Lee HT.
FASEB J. 2020 Feb 21. doi: 10.1096/fj.201903287R. [Epub ahead of print]

Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy.
Che H, Wang Y, Li H, Li Y, Sahil A, Lv J, Liu Y, Yang Z, Dong R, Xue H, Wang L.
FASEB J. 2020 Feb 17. doi: 10.1096/fj.201902692R. [Epub ahead of print]

Extracellular vesicle-mediated amyloid transfer to neural progenitor cells: implications for RAGE and HIV infection.
András IE, Garcia-Contreras M, Yanick C, Perez P, Sewell B, Durand L, Toborek M.
Mol Brain. 2020 Feb 17;13(1):21. doi: 10.1186/s13041-020-0562-0.

Activation of autophagy inhibits NLRP3 inflammasome activation and attenuates myocardial ischemia-reperfusion injury in diabetic rats.
Zhang D, He Y, Ye X, Cai Y, Xu J, Zhang L, Li M, Liu H, Wang S, Xia Z.
Diabetes Investig. 2020 Feb 16. doi: 10.1111/jdi.13235. [Epub ahead of print]

Lipidomics analysis of timosaponin BII in INS-1 cells induced by glycolipid toxicity and its relationship with inflammation.
Shi K, Zhu J, Chen D, Ren C, Guo M, Wang J, Wu X, Feng Y.
Chem Biodivers. 2020 Feb 16. doi: 10.1002/cbdv.201900684. [Epub ahead of print]

Palmitate induces apoptotic cell death and inflammasome activation in human placental macrophages.
Rogers LM, Serezani CH, Eastman AJ, Hasty AH, Englund-Ögge L, Jacobsson B, Vickers KC, Aronoff DM.
Placenta. 2020 Jan 15;90:45-51. doi: 10.1016/j.placenta.2019.12.009. Epub 2019 Dec 9.

Lespedeza bicolor Extract Ameliorated Renal Inflammation by Regulation of NLRP3 Inflammasome-Associated Hyperinflammation in Type 2 Diabetic Mice.
Park JE, Lee H, Kim SY, Lim Y.
Antioxidants (Basel). 2020 Feb 10;9(2). pii: E148. doi: 10.3390/antiox9020148.

Role of NLRP3-Inflammasome/Caspase-1/Galectin-3 Pathway on Atrial Remodeling in Diabetic Rabbits.
Wu X, Liu Y, Tu D, Liu X, Niu S, Suo Y, Liu T, Li G, Liu C.
J Cardiovasc Transl Res. 2020 Feb 11. doi: 10.1007/s12265-020-09965-8. [Epub ahead of print]

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance.
He M, Chiang HH, Luo H, Zheng Z, Qiao Q, Wang L, Tan M, Ohkubo R, Mu WC, Zhao S, Wu H, Chen D.
Cell Metab. 2020 Mar 3;31(3):580-591.e5. doi: 10.1016/j.cmet.2020.01.009. Epub 2020 Feb 6.

NOD-like Receptors in the Eye: Uncovering Its Role in Diabetic Retinopathy.
Lim RR, Wieser ME, Ganga RR, Barathi VA, Lakshminarayanan R, Mohan RR, Hainsworth DP, Chaurasia SS.
Int J Mol Sci. 2020 Jan 30;21(3). pii: E899. doi: 10.3390/ijms21030899. Review.

High-Mobility Group Box 1 Protein Signaling in Painful Diabetic Neuropathy.
Thakur V, Sadanandan J, Chattopadhyay M.
Int J Mol Sci. 2020 Jan 30;21(3). pii: E881. doi: 10.3390/ijms21030881.

The Roles of the NLRP3 Inflammasome in Neurodegenerative and Metabolic Diseases and in Relevant Advanced Therapeutic Interventions.
Pirzada RH, Javaid N, Choi S.
Genes (Basel). 2020 Jan 27;11(2). pii: E131. doi: 10.3390/genes11020131. Review.

Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes.
Pereira CA, Carlos D, Ferreira NS, Silva JF, Zanotto CZ, Zamboni DS, Garcia VD, Ventura DF, Silva JS, Tostes RC.
Front Physiol. 2020 Jan 17;10:1557. doi: 10.3389/fphys.2019.01557. eCollection 2019.

Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.
Mirea AM, Stienstra R, Kanneganti TD, Tack CJ, Chavakis T, Toonen EJM, Joosten LAB.
Inflammation. 2020 Jan 30. doi: 10.1007/s10753-020-01190-4. [Epub ahead of print]

Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice.
Hu T, Lu XY, Shi JJ, Liu XQ, Chen QB, Wang Q, Chen YB, Zhang SJ.
J Cell Mol Med. 2020 Jan 30. doi: 10.1111/jcmm.15026. [Epub ahead of print]

Cathelicidin aggravates myocardial ischemia/reperfusion injury via activating TLR4 signaling and P2X7R/NLRP3 inflammasome.
Wu Y, Zhang Y, Zhang J, Zhai T, Hu J, Luo H, Zhou H, Zhang Q, Zhou Z, Liu F.
J Mol Cell Cardiol. 2020 Jan 23;139:75-86. doi: 10.1016/j.yjmcc.2019.12.011. [Epub ahead of print]

Metformin upregulates mitophagy in patients with T2DM: A randomized placebo-controlled study.
Bhansali S, Bhansali A, Dutta P, Walia R, Dhawan V.
J Cell Mol Med. 2020 Jan 23. doi: 10.1111/jcmm.14834. [Epub ahead of print]

PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3inflammasome activation in mice.
Sun CC, Zhang CY, Duan JX, Guan XX, Yang HH, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX, Liu SK, Zhang J.
Biochem Biophys Res Commun. 2020 Mar 19;523(4):1020-1026. doi: 10.1016/j.bbrc.2019.12.131. Epub 2020 Jan 20.

Recent progress on the discovery of NLRP3 inhibitors and their therapeutic potential.
Su M, Wang W, Liu F, Li H.
Curr Med Chem. 2020 Jan 22. doi: 10.2174/0929867327666200123093544. [Epub ahead of print]

Neutrophil Extracellular Traps and Cardiovascular Diseases: An Update.
Bonaventura A, Vecchié A, Abbate A, Montecucco F.
Cells. 2020 Jan 17;9(1). pii: E231. doi: 10.3390/cells9010231. Review.

Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure.
Byrne NJ, Matsumura N, Maayah ZH, Ferdaoussi M, Takahara S, Darwesh AM, Levasseur JL, Jahng JWS, Vos D, Parajuli N, El-Kadi AOS, Braam B, Young ME, Verma S, Light PE, Sweeney G, Seubert JM, Dyck JRB.
Circ Heart Fail. 2020 Jan;13(1):e006277. doi: 10.1161/CIRCHEARTFAILURE.119.006277. Epub 2020 Jan 20.

Innate immunity in diabetic kidney disease.
Tang SCW, Yiu WH.
Nat Rev Nephrol. 2020 Jan 15. doi: 10.1038/s41581-019-0234-4. [Epub ahead of print] Review.

Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis Following Myocardial Infarction.
Sreejit G, Abdel-Latif A, Athmanathan B, Annabathula R, Dhyani A, Noothi SK, Quaife-Ryan GA, Al-Sharea A, Pernes G, Dragoljevic D, Lal H, Schroder K, Hanaoka BY, Raman C, Grant MB, Hudson JE, Smyth S, Porrello ER, Murphy AJ, Nagareddy PR.
Circulation. 2020 Jan 16. doi: 10.1161/CIRCULATIONAHA.119.043833. [Epub ahead of print]

The antagonism of 6-shogaol in high-glucose-activated NLRP3 inflammasome and consequent calcification of human artery smooth muscle cells.
Chen TC, Yen CK, Lu YC, Shi CS, Hsieh RZ, Chang SF, Chen CN.
Cell Biosci. 2020 Jan 9;10:5. doi: 10.1186/s13578-019-0372-1. eCollection 2020.

A promiscuous inflammasome sparks replication of a common tumor virus.
Burton EM, Goldbach-Mansky R, Bhaduri-McIntosh S.
Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1722-1730. doi: 10.1073/pnas.1919133117. Epub 2020 Jan 9.

Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart.
Fender AC, Kleeschulte S, Stolte S, Leineweber K, Kamler M, Bode J, Li N, Dobrev D.
Basic Res Cardiol. 2020 Jan 7;115(2):10. doi: 10.1007/s00395-019-0771-9.

[Expressions of Thioredoxin Interacting Protein/Nucleotide-binding Oligomerization Domain-like Receptor Protein 3 Inflammasome in the Sciatic Nerve of Streptozotocin-induced Diabetic Rats].
Sun Q, Wang C, Yan B, Shi HX, Shi Y, Qu L, Liang CX.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Dec 30;41(6):799-805. doi: 10.3881/j.issn.1000-503X.11468. Chinese. 

Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway.
Wei H, Bu R, Yang Q, Jia J, Li T, Wang Q, Chen Y.
Diabetes Res. 2019 Dec 9;2019:8905917. doi: 10.1155/2019/8905917. eCollection 2019.

Hydrogen sulfide modulates high glucose-induced NLRP3 inflammasome activation in 3T3-L1 adipocytes.
Hu TX, Zhang NN, Ruan Y, Tan QY, Wang J.
Exp Ther Med. 2020 Jan;19(1):771-776. doi: 10.3892/etm.2019.8242. Epub 2019 Nov 26.

ALDH2 Overexpression Alleviates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3Inflammasome Activation.
Cao R, Fang D, Wang J, Yu Y, Ye H, Kang P, Li Z, Wang H, Gao Q.
Diabetes Res. 2019 Nov 21;2019:4857921. doi: 10.1155/2019/4857921. eCollection 2019.

Dexmedetomidine attenuates P2X4 and NLRP3 expression in the spine of rats with diabetic neuropathic pain.
Kang L, Yayi H, Fang Z, Bo Z, Zhongyuan X.
Acta Cir Bras. 2019 Dec 20;34(11):e201901105. doi: 10.1590/s0102-865020190110000005. eCollection 2019.

Wnt7a regulates high autophagic and inflammatory response of epidermis in high-glucose environment.
Wang W, Zhang F, Yan X, Tan Q.
Burns. 2020 Feb;46(1):121-127. doi: 10.1016/j.burns.2019.07.025. Epub 2019 Dec 15.

lncRNA GAS5/miR-452-5p Reduces Oxidative Stress and Pyroptosis of High-Glucose-Stimulated Renal Tubular Cells.
Xie C, Wu W, Tang A, Luo N, Tan Y.
Diabetes Metab Syndr Obes. 2019 Dec 9;12:2609-2617. doi: 10.2147/DMSO.S228654. eCollection 2019.

Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes.
Ding S, Xu S, Ma Y, Liu G, Jang H, Fang J.
Biomolecules. 2019 Dec 9;9(12). pii: E850. doi: 10.3390/biom9120850. Review.

NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway.
Dwivedi DK, Jena GB.
Naunyn Schmiedebergs Arch Pharmacol. 2020 Apr;393(4):705-716. doi: 10.1007/s00210-019-01773-5. Epub 2019 Dec 13.

NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus.
Ferreira NS, Bruder-Nascimento T, Pereira CA, Zanotto CZ, Prado DS, Silva JF, Rassi DM, Foss-Freitas MC, Alves-Filho JC, Carlos D, Tostes RC.
Cells. 2019 Dec 8;8(12). pii: E1595. doi: 10.3390/cells8121595.

A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications.
Yu ZW, Zhang J, Li X, Wang Y, Fu YH, Gao XY.
Life Sci. 2020 Jan 1;240:117138. doi: 10.1016/j.lfs.2019.117138. Epub 2019 Dec 4. Review.

Jinmaitong Ameliorates Diabetic Peripheral Neuropathy Through Suppressing TXNIP/NLRP3Inflammasome Activation In The Streptozotocin-Induced Diabetic Rat Model
Sun Q, Wang C, Yan B, Shi X, Shi Y, Qu L, Liang X.
Diabetes Metab Syndr Obes. 2019 Oct 17;12:2145-2155. doi: 10.2147/DMSO.S223842. eCollection 2019.

Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide.
Dwivedi DK, Jena GB.
Biochem Biophys Res Commun. 2020 Feb 5;522(2):381-387. doi: 10.1016/j.bbrc.2019.11.100. Epub 2019 Nov 22.

A new strategy for the treatment of atherothrombosis – inhibition of inflammation.
Slíva J, Charalambous C, Bultas J, Karetová D.
Physiol Res. 2019 Nov 22;68(Suppl 1):S17-S30.

Pharmacological Inhibitors of the NLRP3 Inflammasome.
Zahid A, Li B, Kombe AJK, Jin T, Tao J.
Front Immunol. 2019 Oct 25;10:2538. doi: 10.3389/fimmu.2019.02538. eCollection 2019. Review.

AdipoRon Alleviates Free Fatty Acid-Induced Myocardial Cell Injury Via Suppressing Nlrp3Inflammasome Activation.
Zhang YZ, Zhang YL, Huang Q, Huang C, Jiang ZL, Cai F, Shen JF.
Diabetes Metab Syndr Obes. 2019 Oct 23;12:2165-2179. doi: 10.2147/DMSO.S221841. eCollection 2019.

Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs.
Hu R, Wang MQ, Ni SH, Wang M, Liu LY, You HY, Wu XH, Wang YJ, Lu L, Wei LB.
Eur J Pharmacol. 2020 Jan 15;867:172797. doi: 10.1016/j.ejphar.2019.172797. Epub 2019 Nov 17.

Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetic by modulating the NLRP3 and Keap1/Nrf2/HO-1 pathways.
Gao Y, Li J, Chu S, Zhang Z, Chen N, Li L, Zhang L.
Eur J Pharmacol. 2020 Jan 5;866:172801. doi: 10.1016/j.ejphar.2019.172801. Epub 2019 Nov 16.

D-Ribose Induces Podocyte NLRP3 Inflammasome Activation and Glomerular Injury via AGEs/RAGE Pathway.
Hong J, Li G, Zhang Q, Ritter J, Li W, Li PL.
Front Cell Dev Biol. 2019 Oct 30;7:259. doi: 10.3389/fcell.2019.00259. eCollection 2019.

Rapamycin Attenuates High Glucose-Induced Inflammation Through Modulation of mTOR/NF-κB Pathways in Macrophages.
Dai J, Jiang C, Chen H, Chai Y.
Front Pharmacol. 2019 Oct 30;10:1292. doi: 10.3389/fphar.2019.01292. eCollection 2019.

Chemerin-induced macrophages pyroptosis in fetal brain tissue leads to cognitive disorder in offspring of diabetic dams.
Liang Z, Han L, Sun D, Chen Y, Wu Q, Zhang L, Zhou M, Chen D.
J Neuroinflammation. 2019 Nov 16;16(1):226. doi: 10.1186/s12974-019-1573-6.

Allopurinol inhibits excess glucose-induced trophoblast IL-1β and ROS production.
Negi M, Mulla MJ, Han CS, Abrahams VM.
Reproduction. 2020 Jan;159(1):73-80. doi: 10.1530/REP-19-0422.

The SGLT2 inhibitor dapagliflozin attenuates the activity of ROS-NLRP3 inflammasome axis in steatohepatitis with diabetes mellitus.
Leng W, Wu M, Pan H, Lei X, Chen L, Wu Q, Ouyang X, Liang Z.
Ann Transl Med. 2019 Sep;7(18):429. doi: 10.21037/atm.2019.09.03.

Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide.
Faridi A, Sun Y, Mortimer M, Aranha RR, Nandakumar A, Li Y, Javed I, Kakinen A, Fan Q, Purcell AW, Davis TP, Ding F, Faridi P, Ke PC.
Nano Res. 2019 Nov;12(11):2827-2834. doi: 10.1007/s12274-019-2520-7. Epub 2019 Sep 26.

PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages.
Jo SI, Bae JH, Kim SJ, Lee JM, Jeong JH, Moon JS.
Diabetes Metab J. 2019 Oct;43(5):683-699. doi: 10.4093/dmj.2019.0112.

Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis.
Kang P, Wang J, Fang D, Fang T, Yu Y, Zhang W, Shen L, Li Z, Wang H, Ye H, Gao Q.
Free Radic Biol Med. 2020 Jan;146:198-210. doi: 10.1016/j.freeradbiomed.2019.10.416. Epub 2019 Nov 2.

Endothelial acid ceramidase in exosome-mediated release of NLRP3 inflammasome products during hyperglycemia: Evidence from endothelium-specific deletion of Asah1 gene.
Yuan X, Bhat OM, Lohner H, Zhang Y, Li PL.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec;1864(12):158532. doi: 10.1016/j.bbalip.2019.158532. Epub 2019 Oct 21.

Ethanol and its metabolites: update on toxicity, benefits, and focus on immunomodulatory effects.
Le Daré B, Lagente V, Gicquel T.
Drug Metab Rev. 2019 Nov;51(4):545-561. doi: 10.1080/03602532.2019.1679169. Epub 2019 Oct 24. Review.

Resveratrol inhibits high-glucose-induced inflammatory “metabolic memory” in human retinal vascular endothelial cells through SIRT1-dependent signaling.
Jiang T, Gu J, Chen W, Chang Q.
Can J Physiol Pharmacol. 2019 Dec;97(12):1141-1151. doi: 10.1139/cjpp-2019-0201. Epub 2019 Oct 22.

Nigericin Promotes NLRP3-Independent Bacterial Killing in Macrophages.
Armstrong H, Bording-Jorgensen M, Chan R, Wine E.
Front Immunol. 2019 Oct 1;10:2296. doi: 10.3389/fimmu.2019.02296. eCollection 2019.

Suppression of Glucagon-Like Peptide-1 Release by Inhibition of Intestinal NLRP3 Inflammasome Activation in Asc-/- and Nlrp3-/- Mice.
Chen Y, Kidd J, Bhat OM, Yuan X, Hong J, He X, Li PL.
Front Physiol. 2019 Oct 1;10:1213. doi: 10.3389/fphys.2019.01213. eCollection 2019.

Hyperglycemia aggravates acute liver injury by promoting liver-resident macrophage NLRP3inflammasome activation via the inhibition of AMPK/mTOR-mediated autophagy induction.
Wang Q, Wei S, Zhou S, Qiu J, Shi C, Liu R, Zhou H, Lu L.
Immunol Cell Biol. 2020 Jan;98(1):54-66. doi: 10.1111/imcb.12297. Epub 2019 Nov 19.

Exogenous Hydrogen Sulfide Alleviates-Induced Intracellular Inflammation in HepG2 Cells.
Wang YD, Li JY, Qin Y, Liu Q, Liao ZZ, Xiao XH.
Exp Clin Endocrinol Diabetes. 2020 Mar;128(3):137-143. doi: 10.1055/a-0999-0149. Epub 2019 Oct 17.

miR-590-3p Inhibits Pyroptosis in Diabetic Retinopathy by Targeting NLRP1 and Inactivating the NOX4 Signaling Pathway.
Gu C, Draga D, Zhou C, Su T, Zou C, Gu Q, Lahm T, Zheng Z, Qiu Q.
Invest Ophthalmol Vis Sci. 2019 Oct 1;60(13):4215-4223. doi: 10.1167/iovs.19-27825.

In Silico Insights towards the Identification of NLRP3 Druggable Hot Spots.
Mekni N, De Rosa M, Cipollina C, Gulotta MR, De Simone G, Lombino J, Padova A, Perricone U.
Int J Mol Sci. 2019 Oct 9;20(20). pii: E4974. doi: 10.3390/ijms20204974.

Advanced Glycation End Products (AGEs) Induce Apoptosis of Fibroblasts by Activation of NLRP3Inflammasome via Reactive Oxygen Species (ROS) Signaling Pathway.
Dai J, Chen H, Chai Y.
Med Sci Monit. 2019 Oct 6;25:7499-7508. doi: 10.12659/MSM.915806.

Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells.
Zhang Y, Wang YT, Koka S, Zhang Y, Hussain T, Li X.
Front Biosci (Landmark Ed). 2020 Jan 1;25:283-298.

NLRP3 Inflammasome: A Novel Player in Metabolically Induced Inflammation-Potential Influence on the Myocardium.
Sokolova M, Ranheim T, Louwe MC, Halvorsen B, Yndestad A, Aukrust P.
J Cardiovasc Pharmacol. 2019 Oct;74(4):276-284. doi: 10.1097/FJC.0000000000000704.

Gamma-tocopherol ameliorates hyperglycemia-induced hepatic inflammation associated with NLRP3inflammasome in alloxan-induced diabetic mice.
Lee H, Lim Y.
Nutr Res Pract. 2019 Oct;13(5):377-383. doi: 10.4162/nrp.2019.13.5.377. Epub 2019 Jul 10.

NLRP3 inflammasome promotes diabetes-induced endothelial inflammation and atherosclerosis.
Wan Z, Fan Y, Liu X, Xue J, Han Z, Zhu C, Wang X.
Diabetes Metab Syndr Obes. 2019 Sep 20;12:1931-1942. doi: 10.2147/DMSO.S222053. eCollection 2019. 

Astragaloside IV attenuates gestational diabetes mellitus via targeting NLRP3 inflammasome in genetic mice.
Zhang R, Zhang X, Xing B, Zhao J, Zhang P, Shi D, Yang F.
Reprod Biol Endocrinol. 2019 Sep 26;17(1):77. doi: 10.1186/s12958-019-0522-7.

Nlrp1b1 negatively modulates obesity-induced inflammation by promoting IL-18 production.
Salazar-León J, Valdez-Hernández AL, García-Jiménez S, Román-Domínguez L, Huanosta-Murillo E, Bonifaz LC, Pérez-Martínez L, Pedraza-Alva G.
Sci Rep. 2019 Sep 25;9(1):13815. doi: 10.1038/s41598-019-49546-7.

NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling.
Unamuno X, Gómez-Ambrosi J, Ramírez B, Rodríguez A, Becerril S, Valentí V, Moncada R, Silva C, Salvador J, Frühbeck G, Catalán V.
Cell Mol Immunol. 2019 Sep 24. doi: 10.1038/s41423-019-0296-z. [Epub ahead of print]

Protective effects of acarbose against vascular endothelial dysfunction through inhibiting Nox4/NLRP3inflammasome pathway in diabetic rats.
Li XX, Ling SK, Hu MY, Ma Y, Li Y, Huang PL.
Free Radic Biol Med. 2019 Dec;145:175-186. doi: 10.1016/j.freeradbiomed.2019.09.015. Epub 2019 Sep 18.

Blockade of the Adenosine A3 Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1β and IL-18 in Diabetic Rats.
Garrido W, Jara C, Torres A, Suarez R, Cappelli C, Oyarzún C, Quezada C, San Martín R.
Int J Mol Sci. 2019 Sep 13;20(18). pii: E4531. doi: 10.3390/ijms20184531.

Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE-/- mice.
Tang G, Duan F, Li W, Wang Y, Zeng C, Hu J, Li H, Zhang X, Chen Y, Tan H.
Biomed Pharmacother. 2019 Nov;119:109410. doi: 10.1016/j.biopha.2019.109410. Epub 2019 Sep 10.

Cilostazol ameliorates high free fatty acid (FFA)-induced activation of NLRP3 inflammasome in human vascular endothelial cells.
Wang X, Huang H, Su C, Zhong Q, Wu G.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3704-3710. doi: 10.1080/21691401.2019.1665058.

Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3inflammasome pathway in diabetic mice.
Wei W, Li XX, Xu M.
Atherosclerosis. 2019 Oct;289:132-142. doi: 10.1016/j.atherosclerosis.2019.08.017. Epub 2019 Aug 29.

NLRP3 inflammasome inhibitor glyburide expedites diabetic-induced impaired fracture healing.
Yang X, Qu C, Jia J, Zhan Y.
Immunobiology. 2019 Nov;224(6):786-791. doi: 10.1016/j.imbio.2019.08.008. Epub 2019 Aug 23.

Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice.
Lee HJ, Yang SJ.
Int J Mol Sci. 2019 Aug 27;20(17). pii: E4196. doi: 10.3390/ijms20174196.

Activation of ROS/MAPKs/NF-κB/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis.
An Y, Zhang H, Wang C, Jiao F, Xu H, Wang X, Luan W, Ma F, Ni L, Tang X, Liu M, Guo W, Yu L.
FASEB J. 2019 Nov;33(11):12515-12527. doi: 10.1096/fj.201802805RR. Epub 2019 Aug 28.

Data on microbial DNA-induced IL-1β production in monocytes of type 1 diabetes patients.
Zentsova I, Parackova Z, Kayserova J, Palova-Jelinkova L, Vrabcova P, Volfova N, Sumnik Z, Pruhova S, Petruzelkova L, Sediva A.
Data Brief. 2019 Jul 27;25:104321. doi: 10.1016/j.dib.2019.104321. eCollection 2019 Aug.

A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation.
Zhang C, Zhu X, Li L, Ma T, Shi M, Yang Y, Fan Q.
Diabetes Metab Syndr Obes. 2019 Aug 2;12:1297-1309. doi: 10.2147/DMSO.S199802. eCollection 2019.

Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta-Analysis of 19 005 Individuals.
Murphy AM, Smith CE, Murphy LM, Follis JL, Tanaka T, Richardson K, Noordam R, Lemaitre RN, Kähönen M, Dupuis J, Voortman T, Marouli E, Mook-Kanamori DO, Raitakari OT, Hong J, Dehghan A, Dedoussis G, de Mutsert R, Lehtimäki T, Liu CT, Rivadeneira F, Deloukas P, Mikkilä V, Meigs JB, Uitterlinden A, Ikram MA, Franco OH, Hughes M, O’ Gaora P, Ordovás JM, Roche HM.
Mol Nutr Food Res. 2019 Nov;63(22):e1900226. doi: 10.1002/mnfr.201900226. Epub 2019 Sep 12.

Low Methoxyl Pectin Protects against Autoimmune Diabetes and Associated Caecal Dysfunction.
Wu C, Pan LL, Luo Y, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Yang G, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P, Sun J.
Mol Nutr Food Res. 2019 Nov;63(21):e1900307. doi: 10.1002/mnfr.201900307. Epub 2019 Sep 5.

Klotho improves diabetic cardiomyopathy by suppressing the NLRP3 inflammasome pathway.
Li X, Li Z, Li B, Zhu X, Lai X.
Life Sci. 2019 Oct 1;234:116773. doi: 10.1016/j.lfs.2019.116773. Epub 2019 Aug 15.

Compound C attenuates NLRP3 inflammasome despite AMPK knockdown in LPS plus palmitate-induced THP-1 cells.
Liu Y, He H, Fan L, Yuan J, Huang H, Yang W, Wang L, Mo Z, Wang F.
Naunyn Schmiedebergs Arch Pharmacol. 2020 Jan;393(1):67-76. doi: 10.1007/s00210-019-01712-4. Epub 2019 Aug 16.

Caffeic Acid Inhibits the Formation of Advanced Glycation End Products (AGEs) and Mitigates the AGEs-Induced Oxidative Stress and Inflammation Reaction in Human Umbilical Vein Endothelial Cells (HUVECs).
Cao X, Xia Y, Zeng M, Wang W, He Y, Liu J.
Chem Biodivers. 2019 Oct;16(10):e1900174. doi: 10.1002/cbdv.201900174. Epub 2019 Sep 3.

Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice.
Wu C, Pan LL, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P, Sun J.
Front Immunol. 2019 Jul 30;10:1733. doi: 10.3389/fimmu.2019.01733. eCollection 2019.

Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection.
Swidergall M, Khalaji M, Solis NV, Moyes DL, Drummond RA, Hube B, Lionakis MS, Murdoch C, Filler SG, Naglik JR.
J Infect Dis. 2019 Sep 26;220(9):1477-1488. doi: 10.1093/infdis/jiz322.

DPP-4 inhibition by linagliptin prevents cardiac dysfunction and inflammation by targeting the Nlrp3/ASC inflammasome.
Birnbaum Y, Tran D, Bajaj M, Ye Y.
Basic Res Cardiol. 2019 Aug 6;114(5):35. doi: 10.1007/s00395-019-0743-0.

Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats.
Qin Q, Lin N, Huang H, Zhang X, Cao X, Wang Y, Li P.
Diabetes Metab Syndr Obes. 2019 Jul 10;12:1091-1103. doi: 10.2147/DMSO.S208989. eCollection 2019.

NLRP3 inflammasome: a novel player in metabolically-induced inflammation – potential influence on the myocardium.
Sokolova M, Ranheim T, Louwe MC, Halvorsen B, Yndestad A, Aukrust P.
J Cardiovasc Pharmacol. 2019 Jul 22. doi: 10.1097/FJC.0000000000000704. [Epub ahead of print]

The protective effects of orexin a against high glucose-induced activation of NLRP3 inflammasome in human vascular endothelial cells.
Zhang C, Abdukerim M, Abilailieti M, Tang L, Ling Y, Pan S.
Arch Biochem Biophys. 2019 Sep 15;672:108052. doi: 10.1016/ Epub 2019 Jul 24.

Novel evidence that an alternative complement cascade pathway is involved in optimal mobilization of hematopoietic stem/progenitor cells in Nlrp3 inflammasome-dependent manner.
Adamiak M, Lenkiewicz AM, Cymer M, Kucia M, Ratajczak J, Ratajczak MZ.
Leukemia. 2019 Dec;33(12):2967-2970. doi: 10.1038/s41375-019-0530-9. Epub 2019 Jul 26. No abstract available. 

Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells.
Mukhamedova N, Hoang A, Dragoljevic D, Dubrovsky L, Pushkarsky T, Low H, Ditiatkovski M, Fu Y, Ohkawa R, Meikle PJ, Horvath A, Brichacek B, Miller YI, Murphy A, Bukrinsky M, Sviridov D.
PLoS Pathog. 2019 Jul 25;15(7):e1007907. doi: 10.1371/journal.ppat.1007907. eCollection 2019 Jul.

Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and NLRP3inflammasome activation.
Wang Y, Li H, Li Y, Zhao Y, Xiong F, Liu Y, Xue H, Yang Z, Ni S, Sahil A, Che H, Wang L.
Phytother Res. 2019 Oct;33(10):2737-2748. doi: 10.1002/ptr.6448. Epub 2019 Jul 23.

Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications.
Zeng C, Wang R, Tan H.
Int J Biol Sci. 2019 May 20;15(7):1345-1357. doi: 10.7150/ijbs.33568. eCollection 2019. Review.

Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal.
Liao Y, Zhang H, He D, Wang Y, Cai B, Chen J, Ma J, Liu Z, Wu Y.
Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):3034-3045. doi: 10.1167/iovs.18-26360.

Dulaglutide inhibits high glucose- induced endothelial dysfunction and NLRP3 inflammasome activation.
Luo X, Hu Y, He S, Ye Q, Lv Z, Liu J, Chen X.
Arch Biochem Biophys. 2019 Aug 15;671:203-209. doi: 10.1016/ Epub 2019 Jul 11.

Blocking Inflammasome Activation Caused by β-Amyloid Peptide (Aβ) and Islet Amyloid Polypeptide (IAPP) through an IAPP Mimic.
Aftabizadeh M, Tatarek-Nossol M, Andreetto E, El Bounkari O, Kipp M, Beyer C, Latz E, Bernhagen J, Kapurniotu A.
ACS Chem Neurosci. 2019 Aug 21;10(8):3703-3717. doi: 10.1021/acschemneuro.9b00260. Epub 2019 Jul 25.

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation.
Kelley N, Jeltema D, Duan Y, He Y.
Int J Mol Sci. 2019 Jul 6;20(13). pii: E3328. doi: 10.3390/ijms20133328. Review.

Chaetocin attenuates gout in mice through inhibiting HIF-1α and NLRP3 inflammasome-dependent IL-1β secretion in macrophages.
Mian Wu, Zhang M, Ma Y, Liu F, Chen S, Lu J, Chen H.
Arch Biochem Biophys. 2019 Jul 30;670:94-103. doi: 10.1016/ Epub 2019 Jun 28.

The effect of NLRP inflammasome on the regulation of AGEs-induced inflammatory response in human periodontal ligament cells.
Yi X, Zhang L, Lu W, Tan X, Yue J, Wang P, Xu W, Ye L, Huang D.
J Periodontal Res. 2019 Dec;54(6):681-689. doi: 10.1111/jre.12677. Epub 2019 Jun 27.

Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis.
Liu B, Mao X, Huang D, Li F, Dong N.
Diabetes Metab Syndr Obes. 2019 May 27;12:801-811. doi: 10.2147/DMSO.S206558. eCollection 2019.

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy.
Göös H, Fogarty CL, Sahu B, Plagnol V, Rajamäki K, Nurmi K, Liu X, Einarsdottir E, Jouppila A, Pettersson T, Vihinen H, Krjutskov K, Saavalainen P, Järvinen A, Muurinen M, Greco D, Scala G, Curtis J, Nordström D, Flaumenhaft R, Vaarala O, Kovanen PE, Keskitalo S, Ranki A, Kere J, Lehto M, Notarangelo LD, Nejentsev S, Eklund KK, Varjosalo M, Taipale J, Seppänen MRJ.
J Allergy Clin Immunol. 2019 Nov;144(5):1364-1376. doi: 10.1016/j.jaci.2019.06.003. Epub 2019 Jun 13.

Phytochemicals as Novel Therapeutic Strategies for NLRP3 Inflammasome-Related Neurological, Metabolic, and Inflammatory Diseases.
Pellegrini C, Fornai M, Antonioli L, Blandizzi C, Calderone V.
Int J Mol Sci. 2019 Jun 13;20(12). pii: E2876. doi: 10.3390/ijms20122876. Review.

MiR-30a Regulates S100A12-induced Retinal Microglial Activation and Inflammation by Targeting NLRP3.
Dong N, Wang Y.
Curr Eye Res. 2019 Nov;44(11):1236-1243. doi: 10.1080/02713683.2019.1632350. Epub 2019 Jun 27.

Inflammatory Consequences of Maternal Diabetes on the Offspring Brain: a Hippocampal Organotypic Culture Study.
Głombik K, Trojan E, Kurek A, Budziszewska B, Basta-Kaim A.
Neurotox Res. 2019 Aug;36(2):357-375. doi: 10.1007/s12640-019-00070-6. Epub 2019 Jun 13.

Interleukin-1β Inhibition for Chronic Kidney Disease in Obese Mice With Type 2 Diabetes.
Lei Y, Devarapu SK, Motrapu M, Cohen CD, Lindenmeyer MT, Moll S, Kumar SV, Anders HJ.
Front Immunol. 2019 May 29;10:1223. doi: 10.3389/fimmu.2019.01223. eCollection 2019.

Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy.
Yang F, Qin Y, Wang Y, Meng S, Xian H, Che H, Lv J, Li Y, Yu Y, Bai Y, Wang L.
Int J Biol Sci. 2019 Mar 10;15(5):1010-1019. doi: 10.7150/ijbs.29680. eCollection 2019.

NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes.
Hong P, Gu RN, Li FX, Xiong XX, Liang WB, You ZJ, Zhang HF.
J Neuroinflammation. 2019 Jun 7;16(1):121. doi: 10.1186/s12974-019-1498-0. Review.

Frontline Science: Acyl-CoA synthetase 1 exacerbates lipotoxic inflammasome activation in primary macrophages.
Kalugotla G, He L, Weber KJ, Daemen S, Reller A, Razani B, Schilling JD.
J Leukoc Biol. 2019 Oct;106(4):803-814. doi: 10.1002/JLB.3HI0219-045RR. Epub 2019 Jun 5.

Suppression of NLRP3 inflammasome improves alveolar bone defect healing in diabetic rats.
Li H, Zhong X, Chen Z, Li W.
J Orthop Surg Res. 2019 May 30;14(1):167. doi: 10.1186/s13018-019-1215-9.

Role of serum amyloid A in atherosclerosis.
Shridas P, Tannock LR.
Curr Opin Lipidol. 2019 Aug;30(4):320-325. doi: 10.1097/MOL.0000000000000616.

Aerobic Exercise Improves Synaptic-Related Proteins of Diabetic Rats by Inhibiting FOXO1/NF-κB/NLRP3 Inflammatory Signaling Pathway and Ameliorating PI3K/Akt Insulin Signaling Pathway.
Wang Q, Hu J, Liu Y, Li J, Liu B, Li M, Lou S.
J Mol Neurosci. 2019 Sep;69(1):28-38. doi: 10.1007/s12031-019-01302-2. Epub 2019 May 21.

Downregulation of hsa_circ_0068087 ameliorates TLR4/NF-κB/NLRP3 inflammasome-mediated inflammation and endothelial cell dysfunction in high glucose conditioned by sponging miR-197.
Cheng J, Liu Q, Hu N, Zheng F, Zhang X, Ni Y, Liu J.
Gene. 2019 Aug 15;709:1-7. doi: 10.1016/j.gene.2019.05.012. Epub 2019 May 18.

The Nlrp3 Inflammasome Orchestrates Mobilization of Bone Marrow-Residing Stem Cells into Peripheral Blood.
Lenkiewicz AM, Adamiak M, Thapa A, Bujko K, Pedziwiatr D, Abdel-Latif AK, Kucia M, Ratajczak J, Ratajczak MZ.
Stem Cell Rev Rep. 2019 Jun;15(3):391-403. doi: 10.1007/s12015-019-09890-7.

Mild hypothermia alleviates diabetes aggravated cerebral ischemic injury via activating autophagy and inhibiting pyroptosis.
Tu Y, Guo C, Song F, Huo Y, Geng Y, Guo M, Bao H, Wu X, Fan W.
Brain Res Bull. 2019 Aug;150:1-12. doi: 10.1016/j.brainresbull.2019.05.003. Epub 2019 May 10.

Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation.
Ge C, Xu M, Qin Y, Gu T, Lou D, Li Q, Hu L, Nie X, Wang M, Tan J.
Food Funct. 2019 May 22;10(5):2970-2985. doi: 10.1039/c8fo01653d.

Exosome-like Nanoparticles from Ginger Rhizomes Inhibited NLRP3 Inflammasome Activation.
Chen X, Zhou Y, Yu J.
Mol Pharm. 2019 Jun 3;16(6):2690-2699. doi: 10.1021/acs.molpharmaceut.9b00246. Epub 2019 Apr 30.

ATP-Nlrp3 Inflammasome-Complement Cascade Axis in Sterile Brain Inflammation in Psychiatric Patients and its Impact on Stem Cell Trafficking.
Ratajczak MZ, Mack A, Bujko K, Domingues A, Pedziwiatr D, Kucia M, Ratajczak J, Ulrich H, Kucharska-Mazur J, Samochowiec J.
Stem Cell Rev Rep. 2019 Aug;15(4):497-505. doi: 10.1007/s12015-019-09888-1. Review.

Pigment Nephropathy: Novel Insights into Inflammasome-Mediated Pathogenesis.
Giuliani KTK, Kassianos AJ, Healy H, Gois PHF.
Int J Mol Sci. 2019 Apr 23;20(8). pii: E1997. doi: 10.3390/ijms20081997. Review.

The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress.
Lei XW, Li Q, Zhang JZ, Zhang YM, Liu Y, Yang KH.
Ophthalmic Res. 2019;62(2):80-92. doi: 10.1159/000499020. Epub 2019 Apr 24.

Role of the thioredoxin interacting protein in diabetic nephropathy and the mechanism of regulating NOD‑like receptor protein 3 inflammatory corpuscle.
Gu C, Liu S, Wang H, Dou H.
Int J Mol Med. 2019 Jun;43(6):2440-2450. doi: 10.3892/ijmm.2019.4163. Epub 2019 Apr 11.

Vaspin prevents myocardial injury in rats model of diabetic cardiomyopathy by enhancing autophagy and inhibiting inflammation.
Li X, Ke X, Li Z, Li B.
Biochem Biophys Res Commun. 2019 Jun 18;514(1):1-8. doi: 10.1016/j.bbrc.2019.04.110. Epub 2019 Apr 20.

Statins Promote Interleukin-1β-Dependent Adipocyte Insulin Resistance Through Lower Prenylation, Not Cholesterol.
Henriksbo BD, Tamrakar AK, Xu J, Duggan BM, Cavallari JF, Phulka J, Stampfli MR, Ashkar AA, Schertzer JD.
Diabetes. 2019 Jul;68(7):1441-1448. doi: 10.2337/db18-0999. Epub 2019 Apr 22.

Momordica charantia (bitter melon) modulates adipose tissue inflammasome gene expression and adipose-gut inflammatory cross talk in high-fat diet (HFD)-fed mice.
Nerurkar PV, Orias D, Soares N, Kumar M, Nerurkar VR.
J Nutr Biochem. 2019 Jun;68:16-32. doi: 10.1016/j.jnutbio.2019.03.003. Epub 2019 Mar 23.

The complement receptor C5aR2 promotes protein kinase R expression and contributes to NLRP3inflammasome activation and HMGB1 release from macrophages.
Yu S, Wang D, Huang L, Zhang Y, Luo R, Adah D, Tang Y, Zhao K, Lu B.
J Biol Chem. 2019 May 24;294(21):8384-8394. doi: 10.1074/jbc.RA118.006508. Epub 2019 Apr 10.

Dysregulation of Inflammasome Priming and Activation by MicroRNAs in Human Immune-Mediated Diseases.
Boxberger N, Hecker M, Zettl UK.
J Immunol. 2019 Apr 15;202(8):2177-2187. doi: 10.4049/jimmunol.1801416. Review.

Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption.
Gianfrancesco MA, Dehairs J, L’homme L, Herinckx G, Esser N, Jansen O, Habraken Y, Lassence C, Swinnen JV, Rider MH, Piette J, Paquot N, Legrand-Poels S.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul;1864(7):1017-1030. doi: 10.1016/j.bbalip.2019.04.001. Epub 2019 Apr 4.

Vildagliptin inhibits high free fatty acid (FFA)-induced NLRP3 inflammasome activation in endothelial cells.
Qi Y, Du X, Yao X, Zhao Y.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1067-1074. doi: 10.1080/21691401.2019.1578783.

Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7 (Nek7) expression.
Zhou X, Zhang P, Wang Q, Ji N, Xia S, Ding Y, Wang Q.
J Periodontol. 2019 Sep;90(9):1032-1042. doi: 10.1002/JPER.18-0528. Epub 2019 Jul 1.

Spleen tyrosine kinase‑induced JNK‑dependent NLRP3 activation is involved in diabetic cardiomyopathy.
Li S, Liu R, Xue M, Qiao Y, Chen Y, Long G, Tian X, Hu Y, Zhou P, Dong X, Qi Z, Cui Y, Shen Y.
Int J Mol Med. 2019 Jun;43(6):2481-2490. doi: 10.3892/ijmm.2019.4148. Epub 2019 Mar 27.

Effects of α-lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation.
Kim SM, Ha JS, Han AR, Cho SW, Yang SJ.
BMB Rep. 2019 Oct;52(10):613-618.

Effects of exercise training on inflammasome-related mediators and their associations to glucometabolic variables in patients with combined coronary artery disease and type 2 diabetes mellitus: Sub-study of a randomized control trial.
Zaidi H, Byrkjeland R, Njerve IU, Åkra S, Solheim S, Arnesen H, Seljeflot I, Opstad TB.
Diab Vasc Dis Res. 2019 Jul;16(4):360-368. doi: 10.1177/1479164119836922. Epub 2019 Apr 3.

NLRP3 inflammasome mediates angiotensin II-induced islet β cell apoptosis.
Wang J, Feng Y, Huo H, Zhang X, Yue J, Zhang W, Yan Z, Jiao X.
Acta Biochim Biophys Sin (Shanghai). 2019 May 23;51(5):501-508. doi: 10.1093/abbs/gmz032.

Dual Role of PTPN22 but Not NLRP3 Inflammasome Polymorphisms in Type 1 Diabetes and Celiac Disease in Children.
Smigoc Schweiger D, Goricar K, Hovnik T, Mendez A, Bratina N, Brecelj J, Vidan-Jeras B, Battelino T, Dolzan V.
Front Pediatr. 2019 Mar 12;7:63. doi: 10.3389/fped.2019.00063. eCollection 2019.

Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes.
Qiu Z, He Y, Ming H, Lei S, Leng Y, Xia ZY.
Diabetes Res. 2019 Feb 17;2019:8151836. doi: 10.1155/2019/8151836. eCollection 2019.

Mechanisms of Aerobic Exercise Upregulating the Expression of Hippocampal Synaptic Plasticity-Associated Proteins in Diabetic Rats.
Li J, Liu Y, Liu B, Li F, Hu J, Wang Q, Li M, Lou S.
Neural Plast. 2019 Feb 18;2019:7920540. doi: 10.1155/2019/7920540. eCollection 2019.

Obesity and Cardioprotection.
Femminò S, Pagliaro P, Penna C.
Curr Med Chem. 2020;27(2):230-239. doi: 10.2174/0929867326666190325094453.

Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides.
Pal A, Neo K, Rajamani L, Ferrer FJ, Lane DP, Verma CS, Mortellaro A.
Sci Rep. 2019 Mar 20;9(1):4913. doi: 10.1038/s41598-019-41211-3.

Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome.
Seo JB, Choi YK, Woo HI, Jung YA, Lee S, Lee S, Park M, Lee IK, Jung GS, Park KG.
Diabetes Metab J. 2019 Dec;43(6):830-839. doi: 10.4093/dmj.2018.0181. Epub 2019 Mar 5.

New Insights into the Mechanisms of Action of Topical Administration of GLP-1 in an Experimental Model of Diabetic Retinopathy.
Sampedro J, Bogdanov P, Ramos H, Solà-Adell C, Turch M, Valeri M, Simó-Servat O, Lagunas C, Simó R, Hernández C.
J Clin Med. 2019 Mar 11;8(3). pii: E339. doi: 10.3390/jcm8030339.

Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome.
Xu F, Shen G, Su Z, He Z, Yuan L.
Brain Behav. 2019 Apr;9(4):e01254. doi: 10.1002/brb3.1254. Epub 2019 Mar 11.

Salvia miltiorrhiza in diabetes: A review of its pharmacology, phytochemistry, and safety.
Jia Q, Zhu R, Tian Y, Chen B, Li R, Li L, Wang L, Che Y, Zhao D, Mo F, Gao S, Zhang D.
Phytomedicine. 2019 May;58:152871. doi: 10.1016/j.phymed.2019.152871. Epub 2019 Feb 18. Review.

The LPS/D-Galactosamine-Induced Fulminant Hepatitis Model to Assess the Role of Ligand-Activated Nuclear Receptors on the NLRP3 Inflammasome Pathway In Vivo.
Sebti Y, Ferri L, Zecchin M, Beauchamp J, Mogilenko D, Staels B, Duez H, Pourcet B.
Methods Mol Biol. 2019;1951:189-207. doi: 10.1007/978-1-4939-9130-3_15 

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia.
Ward R, Li W, Abdul Y, Jackson L, Dong G, Jamil S, Filosa J, Fagan SC, Ergul A.
Pharmacol Res. 2019 Apr;142:237-250. doi: 10.1016/j.phrs.2019.01.035. Epub 2019 Feb 25.

[Effect of ursolic acid on cardiomyopathy of mice with diabetes and its mechanism].
Yang ZL, Xu HL, Cheng Y, Zhao JG, Zhou YJ, Weng YJ, Wang XT, Qi MY.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2018 Apr 8;34(4):309-312 339. doi: 10.12047/j.cjap.5638.2018.071. Chinese. 

Fish Oil Derived Omega 3 Fatty Acids Suppress Adipose NLRP3 Inflammasome Signaling in Human Obesity.
Lee KR, Midgette Y, Shah R.
J Endocr Soc. 2018 Dec 24;3(3):504-515. doi: 10.1210/js.2018-00220. eCollection 2019 Mar 1.

Huangkui capsule alleviates renal tubular epithelial-mesenchymal transition in diabetic nephropathy via inhibiting NLRP3 inflammasome activation and TLR4/NF-κB signaling.
Han W, Ma Q, Liu Y, Wu W, Tu Y, Huang L, Long Y, Wang W, Yee H, Wan Z, Tang R, Tang H, Wan Y.
Phytomedicine. 2019 Apr;57:203-214. doi: 10.1016/j.phymed.2018.12.021. Epub 2018 Dec 17.

Inflammasomes, neutrophil extracellular traps, and cholesterol.
Tall AR, Westerterp M.
J Lipid Res. 2019 Apr;60(4):721-727. doi: 10.1194/jlr.S091280. Epub 2019 Feb 19.

Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7(Nek7) expression.
Zhou X, Zhang P, Wang Q, Ji N, Xia S, Ding Y, Wang Q.
J Periodontol. 2019 Feb 19. doi: 10.1002/jper.10311. [Epub ahead of print]

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors.
Yang Y, Wang H, Kouadir M, Song H, Shi F.
Cell Death Dis. 2019 Feb 12;10(2):128. doi: 10.1038/s41419-019-1413-8. Review.

Thioredoxin-Interacting Protein (TXNIP) Associated NLRP3 Inflammasome Activation in Human Alzheimer’s Disease Brain.
Li L, Ismael S, Nasoohi S, Sakata K, Liao FF, McDonald MP, Ishrat T.
J Alzheimers Dis. 2019;68(1):255-265. doi: 10.3233/JAD-180814.

Verapamil Attenuated Prediabetic Neuropathy in High-Fat Diet-Fed Mice through Inhibiting TXNIP-Mediated Apoptosis and Inflammation.
Xu L, Lin X, Guan M, Zeng Y, Liu Y.
Oxid Med Cell Longev. 2019 Jan 10;2019:1896041. doi: 10.1155/2019/1896041. eCollection 2019.

Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy.
Thounaojam MC, Montemari A, Powell FL, Malla P, Gutsaeva DR, Bachettoni A, Ripandelli G, Repossi A, Tawfik A, Martin PM, Facchiano F, Bartoli M.
Diabetes. 2019 May;68(5):1014-1025. doi: 10.2337/db18-0912. Epub 2019 Feb 6.

Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney.
Sahin E, Bektur E, Burukoglu Donmez D, Baycu C, Can OD, Sahinturk V.
Acta Histochem. 2019 Apr;121(3):289-296. doi: 10.1016/j.acthis.2019.01.007. Epub 2019 Jan 31.

Dietary modulation of energy homoeostasis and metabolic-inflammation.
Roche HM.
Proc Nutr Soc. 2019 Aug;78(3):313-318. doi: 10.1017/S0029665118002872. Epub 2019 Feb 1.

Wu-Mei-wan protects pancreatic β cells by inhibiting NLRP3 Inflammasome activation in diabetic mice.
Yang X, Lu F, Li L, Li J, Luo J, Zhang S, Liu X, Chen G.
BMC Complement Altern Med. 2019 Jan 31;19(1):35. doi: 10.1186/s12906-019-2443-6.

Anticytokine Agents: Targeting Interleukin Signaling Pathways for the Treatment of Atherothrombosis
Ridker PM.
Circ Res. 2019 Feb;124(3):437-450. doi: 10.1161/CIRCRESAHA.118.313129. Review.

Anagliptin ameliorates high glucose- induced endothelial dysfunction via suppression of NLRP3inflammasome activation mediated by SIRT1.
Jiang T, Jiang D, Zhang L, Ding M, Zhou H.
Mol Immunol. 2019 Mar;107:54-60. doi: 10.1016/j.molimm.2019.01.006. Epub 2019 Jan 17.

Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1.
Zhang W, Wang Y, Kong Y.
Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):294-303. doi: 10.1167/iovs.18-25617.

The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.
Trotta MC, Maisto R, Guida F, Boccella S, Luongo L, Balta C, D’Amico G, Herman H, Hermenean A, Bucolo C, D’Amico M.
PLoS One. 2019 Jan 18;14(1):e0211005. doi: 10.1371/journal.pone.0211005. eCollection 2019.

NLRP3 activation induced by neutrophil extracellular traps sustains inflammatory response in the diabetic wound.
Liu D, Yang P, Gao M, Yu T, Shi Y, Zhang M, Yao M, Liu Y, Zhang X.
Clin Sci (Lond). 2019 Feb 18;133(4):565-582. doi: 10.1042/CS20180600. Print 2019 Feb 28.

Protective effects of sulforaphane on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of NLRP3 inflammasome formation.
Li S, Yang H, Chen X.
Exp Anim. 2019 May 8;68(2):221-231. doi: 10.1538/expanim.18-0146. Epub 2019 Jan 1.

Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice
Ye T, Meng X, Wang R, Zhang C, He S, Sun G, Sun X.
Int J Mol Sci. 2018 Dec 10;19(12). pii: E3977. doi: 10.3390/ijms19123977.

Gastrodin Ameliorates Cognitive Dysfunction in Diabetes Rat Model via the Suppression of Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation.
Ye T, Meng X, Zhai Y, Xie W, Wang R, Sun G, Sun X.
Front Pharmacol. 2018 Nov 22;9:1346. doi: 10.3389/fphar.2018.01346. eCollection 2018.

Artificially Cultivated Ophiocordyceps sinensis Alleviates Diabetic Nephropathy and Its Podocyte Injury via Inhibiting P2X7R Expression and NLRP3 Inflammasome Activation.
Wang C, Hou XX, Rui HL, Li LJ, Zhao J, Yang M, Sun LJ, Dong HR, Cheng H, Chen YP.
Diabetes Res. 2018 Nov 11;2018:1390418. doi: 10.1155/2018/1390418. eCollection 2018.

SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain.
Tyagi A, Nguyen CU, Chong T, Michel CR, Fritz KS, Reisdorph N, Knaub L, Reusch JEB, Pugazhenthi S.
Sci Rep. 2018 Dec 3;8(1):17547. doi: 10.1038/s41598-018-35890-7.

NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation.
Hughes FM Jr, Hirshman NA, Inouye BM, Jin H, Stanton EW, Yun CE, Davis LG, Routh JC, Purves JT.
Diabetes. 2019 Feb;68(2):430-440. doi: 10.2337/db18-0845. Epub 2018 Nov 13.

Upregulation of proteins of the NLRP3 inflammasome in patients with periodontitis and uncontrolled type 2 diabetes.
García-Hernández AL, Muñoz-Saavedra ÁE, González-Alva P, Moreno-Fierros L, Llamosas-Hernández FE, Cifuentes-Mendiola SE, Rubio-Infante N.
Oral Dis. 2019 Mar;25(2):596-608. doi: 10.1111/odi.13003. Epub 2018 Dec 16.

Prostaglandin E2/EP2 receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes.
Wang M, Wang Y, Xie T, Zhan P, Zou J, Nie X, Shao J, Zhuang M, Tan C, Tan J, Dai Y, Sun J, Li J, Li Y, Shi Q, Leng J, Wang X, Yao Y.
Diabetologia. 2019 Feb;62(2):335-348. doi: 10.1007/s00125-018-4755-3. Epub 2018 Nov 8.

Puerarin inhibits hyperglycemia-induced inter-endothelial junction through suppressing endothelial Nlrp3 inflammasome activation via ROS-dependent oxidative pathway.
Lian D, Yuan H, Yin X, Wu Y, He R, Huang Y, Chen Y.
Phytomedicine. 2019 Mar 1;55:310-319. doi: 10.1016/j.phymed.2018.10.013. Epub 2018 Oct 11.

[Alpha-lipoamide inhibits renal inflammation and collagen 4 production in diabetic rats and its mechanism].
Peng C, Jiang X, Xiao Y, Yuan Z, Mao Y, Wang Wang Y, Zhang Y, Zhang F, Tang L, Guo B.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018 Jul;34(7):617-622. Chinese. 

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.
Krishnan SM, Ling YH, Huuskes BM, Ferens DM, Saini N, Chan CT, Diep H, Kett MM, Samuel CS, Kemp-Harper BK, Robertson AAB, Cooper MA, Peter K, Latz E, Mansell AS, Sobey CG, Drummond GR, Vinh A.
Cardiovasc Res. 2019 Mar 15;115(4):776-787. doi: 10.1093/cvr/cvy252.

Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis.
Tamura N, Maejima Y, Matsumura T, Vega RB, Amiya E, Ito Y, Shiheido-Watanabe Y, Ashikaga T, Komuro I, Kelly DP, Hirao K, Isobe M.
Circ Genom Precis Med. 2018 Oct;11(10):e002296. doi: 10.1161/CIRCGEN.118.002296.

Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells
Song S, Qiu D, Luo F, Wei J, Wu M, Wu H, Du C, Du Y, Ren Y, Chen N, Duan H, Shi Y.
J Mol Endocrinol. 2018 Oct 1;61(3):101-113. doi: 10.1530/JME-18-0069.

Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism.
Arbore G, West EE, Rahman J, Le Friec G, Niyonzima N, Pirooznia M, Tunc I, Pavlidis P, Powell N, Li Y, Liu P, Servais A, Couzi L, Fremeaux-Bacchi V, Placais L, Ferraro A, Walsh PR, Kavanagh D, Afzali B, Lavender P, Lachmann HJ, Kemper C.
Nat Commun. 2018 Oct 10;9(1):4186. doi: 10.1038/s41467-018-06706-z.

Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation.
Lyons CL, Roche HM.
Int J Mol Sci. 2018 Oct 9;19(10). pii: E3092. doi: 10.3390/ijms19103092. Review.

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases.
Xu C, Lu Z, Luo Y, Liu Y, Cao Z, Shen S, Li H, Liu J, Chen K, Chen Z, Yang X, Gu Z, Wang J.
Nat Commun. 2018 Oct 5;9(1):4092. doi: 10.1038/s41467-018-06522-5.

Spotlight on the NLRP3 inflammasome pathway.
Groslambert M, Py BF.
J Inflamm Res. 2018 Sep 25;11:359-374. doi: 10.2147/JIR.S141220. eCollection 2018. Review.

The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice.
Sogawa Y, Nagasu H, Itano S, Kidokoro K, Taniguchi S, Takahashi M, Kadoya H, Satoh M, Sasaki T, Kashihara N.
PLoS One. 2018 Oct 3;13(10):e0203823. doi: 10.1371/journal.pone.0203823. eCollection 2018.

Liraglutide protects non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in a mouse model induced by high-fat diet.
Zhu W, Feng PP, He K, Li SW, Gong JP.
Biochem Biophys Res Commun. 2018 Oct 28;505(2):523-529. doi: 10.1016/j.bbrc.2018.09.134. Epub 2018 Sep 28.

CD36 Promotes Podocyte Apoptosis by Activating the Pyrin Domain-Containing-3 (NLRP3) Inflammasome in Primary Nephrotic Syndrome.
Yang X, Wu Y, Li Q, Zhang G, Wang M, Yang H, Li Q.
Med Sci Monit. 2018 Sep 27;24:6832-6839. doi: 10.12659/MSM.909810.

Knockdown of TLR4 attenuates high glucose-induced podocyte injury via the NALP3/ASC/Caspase-1 signaling pathway.
Liu Y, Xu Z, Ma F, Jia Y, Wang G.
Biomed Pharmacother. 2018 Nov;107:1393-1401. doi: 10.1016/j.biopha.2018.08.134. Epub 2018 Aug 31.

Expression of inflammasome complex mRNA and its targeted microRNA in type 2 diabetes mellitus: A possible predictor of the severity of diabetic nephropathy.
Bhattacharjee CK, Paine SK, Mahanta J, Borphukan S, Borah PK.
Diabetes. 2019 Jan;11(1):90-92. doi: 10.1111/1753-0407.12845. Epub 2018 Sep 30. No abstract available. 

PPARγ Deficiency Suppresses the Release of IL-1β and IL-1α in Macrophages via a Type 1 IFN-Dependent Mechanism.
Weber KJ, Sauer M, He L, Tycksen E, Kalugotla G, Razani B, Schilling JD.
J Immunol. 2018 Oct 1;201(7):2054-2069. doi: 10.4049/jimmunol.1800224. Epub 2018 Aug 24.

Prostaglandin E2 Activates NLRP3 Inflammasome in Endothelial Cells to Promote Diabetic Retinopathy.
Wang Y, Tao J, Yao Y.
Horm Metab Res. 2018 Sep;50(9):704-710. doi: 10.1055/a-0664-0699. Epub 2018 Aug 24.

Regulation of the β-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis.
Ghiasi SM, Dahllöf MS, Osmai Y, Osmai M, Jakobsen KK, Aivazidis A, Tyrberg B, Perruzza L, Prause MCB, Christensen DP, Fog-Tonnesen M, Lundh M, Grassi F, Chatenoud L, Mandrup-Poulsen T.
Mol Cell Endocrinol. 2018 Dec 15;478:106-114. doi: 10.1016/j.mce.2018.08.001. Epub 2018 Aug 16.

Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways.
Zhu X, Shi J, Li H.
Biomed Pharmacother. 2018 Oct;106:976-982. doi: 10.1016/j.biopha.2018.07.045. Epub 2018 Jul 14.

Apocynin inhibited NLRP3/XIAP signalling to alleviate renal fibrotic injury in rat diabetic nephropathy.
Xin R, Sun X, Wang Z, Yuan W, Jiang W, Wang L, Xiang Y, Zhang H, Li X, Hou Y, Sun W, Du P.
Biomed Pharmacother. 2018 Oct;106:1325-1331. doi: 10.1016/j.biopha.2018.07.036. Epub 2018 Jul 21.

The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice.
Wang J, Wang L, Zhou J, Qin A, Chen Z.
Biomed Pharmacother. 2018 Oct;106:1250-1257. doi: 10.1016/j.biopha.2018.07.063. Epub 2018 Jul 20.

Hyperglycemia induces inflammatory mediators in the human chorionic villous.
Corrêa-Silva S, Alencar AP, Moreli JB, Borbely AU, de S Lima L, Scavone C, Damasceno DC, Rudge MVC, Bevilacqua E, Calderon IMP.
Cytokine. 2018 Nov;111:41-48. doi: 10.1016/j.cyto.2018.07.020. Epub 2018 Aug 13.

Renoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats.
Kim SH, Jun JH, Oh JE, Shin EJ, Oh YJ, Choi YS.
PLoS One. 2018 Aug 16;13(8):e0198307. doi: 10.1371/journal.pone.0198307. eCollection 2018.

The role of NLRP3 inflammasome in stroke and central poststroke pain.
Li SJ, Zhang YF, Ma SH, Yi Y, Yu HY, Pei L, Feng D.
Medicine (Baltimore). 2018 Aug;97(33):e11861. doi: 10.1097/MD.0000000000011861. Review. Erratum in: Medicine (Baltimore). 2018 Nov;97(47):e13495

Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-κB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
Song W, Wei L, Du Y, Wang Y, Jiang S.
Int Immunopharmacol. 2018 Oct;63:227-238. doi: 10.1016/j.intimp.2018.07.027. Epub 2018 Aug 11.

NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice.
Wu M, Han W, Song S, Du Y, Liu C, Chen N, Wu H, Shi Y, Duan H.
Mol Cell Endocrinol. 2018 Dec 15;478:115-125. doi: 10.1016/j.mce.2018.08.002. Epub 2018 Aug 8.

Diabetes aggravates acute pancreatitis possibly via activation of NLRP3 inflammasome in db/db mice.
Gao L, Lu GT, Lu YY, Xiao WM, Mao WJ, Tong ZH, Yang N, Li BQ, Yang Q, Ding YB, Li WQ.
Am J Transl Res. 2018 Jul 15;10(7):2015-2025. eCollection 2018.

Effects of antidiabetic drugs on NLRP3 inflammasome activity, with a focus on diabetic kidneys.
Yaribeygi H, Katsiki N, Butler AE, Sahebkar A.
Drug Discov Today. 2019 Jan;24(1):256-262. doi: 10.1016/j.drudis.2018.08.005. Epub 2018 Aug 4. Review.

Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study.
Basiorka AA, McGraw KL, Abbas-Aghababazadeh F, McLemore AF, Vincelette ND, Ward GA, Eksioglu EA, Sallman DA, Ali NA, Padron E, Pinilla-Ibarz J, Komrokji R, Masala E, Santini V, Kosmider O, Fontenay M, Fenaux P, Sokol L, Wei S, Fridley B, List AF.
Lancet Haematol. 2018 Sep;5(9):e393-e402. doi: 10.1016/S2352-3026(18)30109-1. Epub 2018 Jul 30.

Glibenclamide protects against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation.
Dwivedi DK, Jena GB.
Naunyn Schmiedebergs Arch Pharmacol. 2018 Nov;391(11):1257-1274. doi: 10.1007/s00210-018-1540-2. Epub 2018 Jul 31.

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty.
Ferrucci L, Fabbri E.
Nat Rev Cardiol. 2018 Sep;15(9):505-522. doi: 10.1038/s41569-018-0064-2. Review.

GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics.
Tang T, Gong T, Jiang W, Zhou R.
Trends Pharmacol Sci. 2018 Sep;39(9):798-811. doi: 10.1016/ Epub 2018 Jul 24. Review.

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.
Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M.
Nature. 2018 Aug;560(7717):198-203. doi: 10.1038/s41586-018-0372-z. Epub 2018 Jul 25.

Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review.
Cano Sanchez M, Lancel S, Boulanger E, Neviere R.
Antioxidants (Basel). 2018 Jul 24;7(8). pii: E98. doi: 10.3390/antiox7080098. Review.

NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction.
Sokolova M, Sahraoui A, Høyem M, Øgaard J, Lien E, Aukrust P, Yndestad A, Ranheim T, Scholz H.
Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E912-E923. doi: 10.1152/ajpendo.00461.2017. Epub 2018 Jul 17.

IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation.
Morikawa S, Kaneko N, Okumura C, Taguchi H, Kurata M, Yamamoto T, Osawa H, Nakanishi A, Zako T, Masumoto J.
Int J Immunopathol Pharmacol. 2018 Jan-Dec;32:2058738418788749. doi: 10.1177/2058738418788749.

P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes.
D’Addio F, Vergani A, Potena L, Maestroni A, Usuelli V, Ben Nasr M, Bassi R, Tezza S, Dellepiane S, El Essawy B, Iascone M, Iacovoni A, Borgese L, Liu K, Visner G, Dhe-Paganon S, Corradi D, Abdi R, Starling RC, Folli F, Zuccotti GV, Sayegh MH, Heeger PS, Chandraker A, Grigioni F, Fiorina P.
J Clin Invest. 2018 Aug 1;128(8):3490-3503. doi: 10.1172/JCI94524. Epub 2018 Jul 16.

Gypenosides improve diabetic cardiomyopathy by inhibiting ROS-mediated NLRP3 inflammasome activation.
Zhang H, Chen X, Zong B, Yuan H, Wang Z, Wei Y, Wang X, Liu G, Zhang J, Li S, Cheng G, Wang Y, Ma Y.
J Cell Mol Med. 2018 Sep;22(9):4437-4448. doi: 10.1111/jcmm.13743. Epub 2018 Jul 11.

High-density lipoprotein inhibits serum amyloid A-mediated reactive oxygen species generation and NLRP3 inflammasome activation.
Shridas P, De Beer MC, Webb NR.
J Biol Chem. 2018 Aug 24;293(34):13257-13269. doi: 10.1074/jbc.RA118.002428. Epub 2018 Jul 5.

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.
He H, Jiang H, Chen Y, Ye J, Wang A, Wang C, Liu Q, Liang G, Deng X, Jiang W, Zhou R.
Nat Commun. 2018 Jun 29;9(1):2550. doi: 10.1038/s41467-018-04947-6.

Adiponectin inhibits NLRP3 inflammasome by modulating the AMPK-ROS pathway.
Wang F, Liu Y, Yang W, Yuan J, Mo Z.
Int J Clin Exp Pathol. 2018 Jul 1;11(7):3338-3347. eCollection 2018.

Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease.
Farrell GC, Haczeyni F, Chitturi S.
Adv Exp Med Biol. 2018;1061:19-44. doi: 10.1007/978-981-10-8684-7_3. Review.

Annatto Tocotrienol Attenuates NLRP3 Inflammasome Activation in Macrophages.
Buckner T, Fan R, Kim Y, Kim J, Chung S.
Curr Dev Nutr. 2017 May 31;1(6):e000760. doi: 10.3945/cdn.117.000760. eCollection 2017 Jun.

Increased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes.
Cataño Cañizales YG, Uresti Rivera EE, García Jacobo RE, Portales Perez DP, Yadira B, Rodriguez Rivera JG, Amaro RG, Enciso Moreno JA, García Hernández MH.
Iran J Immunol. 2018 Jun;15(2):142-155. doi: IJIv15i2A7.

NLRP3 inflammasome is expressed and regulated in human islets.
Lebreton F, Berishvili E, Parnaud G, Rouget C, Bosco D, Berney T, Lavallard V.
Cell Death Dis. 2018 Jun 25;9(7):726. doi: 10.1038/s41419-018-0764-x.

Naringin ameliorates the high glucose-induced rat mesangial cell inflammatory reaction by modulating the NLRP3 Inflammasome.
Chen F, Wei G, Xu J, Ma X, Wang Q.
BMC Complement Altern Med. 2018 Jun 22;18(1):192. doi: 10.1186/s12906-018-2257-y.

Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy.
Qiao Y, Tian X, Men L, Li S, Chen Y, Xue M, Hu Y, Zhou P, Long G, Shi Y, Liu R, Liu Y, Qi Z, Cui Y, Shen Y.
Mol Med Rep. 2018 Aug;18(2):1995-2008. doi: 10.3892/mmr.2018.9164. Epub 2018 Jun 14.

Intracellular organelles in health and kidney disease.
Shamekhi Amiri F.
Nephrol Ther. 2019 Mar;15(1):9-21. doi: 10.1016/j.nephro.2018.04.002. Epub 2018 Jun 8. Review.

Betaine in Inflammation: Mechanistic Aspects and Applications.
Zhao G, He F, Wu C, Li P, Li N, Deng J, Zhu G, Ren W, Peng Y.
Front Immunol. 2018 May 24;9:1070. doi: 10.3389/fimmu.2018.01070. eCollection 2018. Review.

Does Glycemic Control Modulate the Impairment of NLRP3 Inflammasome Activation in Type 2 Diabetes?
Iannantuoni F, Diaz-Morales N, Escribano-Lopez I, Sola E, Roldan-Torres I, Apostolova N, Bañuls C, Rovira-Llopis S, Rocha M, Victor VM.
Antioxid Redox Signal. 2019 Jan 10;30(2):232-240. doi: 10.1089/ars.2018.7582. Epub 2018 Jul 13.

Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice.
Hong P, Li FX, Gu RN, Fang YY, Lai LY, Wang YW, Tao T, Xu SY, You ZJ, Zhang HF.
Neural Plast. 2018 Apr 24;2018:9163521. doi: 10.1155/2018/9163521. eCollection 2018.

NLRP3: A Novel Mediator in Cardiovascular Disease.
Zhou W, Chen C, Chen Z, Liu L, Jiang J, Wu Z, Zhao M, Chen Y.
J Immunol Res. 2018 Apr 8;2018:5702103. doi: 10.1155/2018/5702103. eCollection 2018. Review.

Exenatide Delays the Progression of Nonalcoholic Fatty Liver Disease in C57BL/6 Mice, Which May Involve Inhibition of the NLRP3 Inflammasome through the Mitophagy Pathway.
Shao N, Yu XY, Ma XF, Lin WJ, Hao M, Kuang HY.
Gastroenterol Res Pract. 2018 Apr 15;2018:1864307. doi: 10.1155/2018/1864307. eCollection 2018.

Inhibition of Interleukin-1β by Canakinumab and Cardiovascular Outcomes in Patients With Chronic Kidney Disease.
Ridker PM, MacFadyen JG, Glynn RJ, Koenig W, Libby P, Everett BM, Lefkowitz M, Thuren T, Cornel JH.
J Am Coll Cardiol. 2018 May 29;71(21):2405-2414. doi: 10.1016/j.jacc.2018.03.490.

Association of Type 2 Diabetes with Submicron Titanium Dioxide Crystals in the Pancreas.
Heller A, Jarvis K, Coffman SS.
Chem Res Toxicol. 2018 Jun 18;31(6):506-509. doi: 10.1021/acs.chemrestox.8b00047. Epub 2018 Jun 5.

Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin.
Lu CP, Huang CY, Wang SH, Chiu CH, Li LH, Hua KF, Wu TH.
Chem Biol Interact. 2018 Jun 25;290:12-18. doi: 10.1016/j.cbi.2018.05.004. Epub 2018 May 17.

Peripheral cannabinoid 1 receptor blockade mitigates adipose tissue inflammation via NLRP3inflammasome in mouse models of obesity.
Han JH, Shin H, Rho JG, Kim JE, Son DH, Yoon J, Lee YJ, Park JH, Song BJ, Choi CS, Yoon SG, Kim IY, Lee EK, Seong JK, Kim KW, Kim W.
Diabetes Obes Metab. 2018 Sep;20(9):2179-2189. doi: 10.1111/dom.13350. Epub 2018 Jun 5.

Mitochondrial Autophagy and NLRP3 Inflammasome in Pulmonary Tissues from Severe Combined Immunodeficient Mice after Cardiac Arrest and Cardiopulmonary Resuscitation.
Lyu JJ, Mehta JL, Li Y, Ye L, Sun SN, Sun HS, Li JC, Zhang DM, Wei J.
Chin Med J (Engl). 2018 May 20;131(10):1174-1184. doi: 10.4103/0366-6999.231519.

Mapping Txnip: Key connexions in progression of diabetic nephropathy.
Kumar A, Mittal R.
Pharmacol Rep. 2018 Jun;70(3):614-622. doi: 10.1016/j.pharep.2017.12.008. Epub 2017 Dec 20. Review.

Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats.
Liu YW, Hao YC, Chen YJ, Yin SY, Zhang MY, Kong L, Wang TY.
Phytother Res. 2018 Aug;32(8):1574-1582. doi: 10.1002/ptr.6088. Epub 2018 Apr 23. Erratum in: Phytother Res. 2019 Sep;33(9):2470

Vitamin D3 Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROS/TXNIP/NLRP3 Inflammasome Pathway.
Lu L, Lu Q, Chen W, Li J, Li C, Zheng Z.
Diabetes Res. 2018 Feb 22;2018:8193523. doi: 10.1155/2018/8193523. eCollection 2018.

NLRP3 Inflammasome Activation Regulates Aged RBC Clearance.
Qin L, Fengyong Z, Jiamin Z, Qixiu Y, Geming L, Rongwei X, Ziyan Z.
Inflammation. 2018 Aug;41(4):1361-1371. doi: 10.1007/s10753-018-0784-9.

Sweet Taste Receptors Mediated ROS-NLRP3 Inflammasome Signaling Activation: Implications for Diabetic Nephropathy.
Zhou L, Huang W, Xu Y, Gao C, Zhang T, Guo M, Liu Y, Ding J, Qin L, Xu Z, Long Y, Xu Y.
Diabetes Res. 2018 Feb 20;2018:7078214. doi: 10.1155/2018/7078214. eCollection 2018.

Self-assembled hyaluronic acid nanoparticles: Implications as a nanomedicine for treatment of type 2 diabetes.
Rho JG, Han HS, Han JH, Lee H, Nguyen VQ, Lee WH, Kwon S, Heo S, Yoon J, Shin HH, Lee EY, Kang H, Yang S, Lee EK, Park JH, Kim W.
J Control Release. 2018 Jun 10;279:89-98. doi: 10.1016/j.jconrel.2018.04.006. Epub 2018 Apr 9.

Methylene Blue Attenuates Diabetic Retinopathy by Inhibiting NLRP3 Inflammasome Activation in STZ-Induced Diabetic Rats.
Hao J, Zhang H, Yu J, Chen X, Yang L.
Ocul Immunol Inflamm. 2019;27(5):836-843. doi: 10.1080/09273948.2018.1450516. Epub 2018 Apr 2.

Cardiovascular diseases, NLRP3 inflammasome, and western dietary patterns.
Pavillard LE, Marín-Aguilar F, Bullon P, Cordero MD.
Pharmacol Res. 2018 May;131:44-50. doi: 10.1016/j.phrs.2018.03.018. Epub 2018 Mar 26. Review.

Mediterranean Diet, Glucose Homeostasis, and Inflammasome Genetic Variants: The CORDIOPREV Study.
Roncero-Ramos I, Rangel-Zuñiga OA, Lopez-Moreno J, Alcala-Diaz JF, Perez-Martinez P, Jimenez-Lucena R, Castaño JP, Roche HM, Delgado-Lista J, Ordovas JM, Camargo A, Lopez-Miranda J.
Mol Nutr Food Res. 2018 May;62(9):e1700960. doi: 10.1002/mnfr.201700960. Epub 2018 Apr 20.

Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy.
Boursereau R, Abou-Samra M, Lecompte S, Noel L, Brichard SM.
BMC Biol. 2018 Mar 20;16(1):33. doi: 10.1186/s12915-018-0501-z.

Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK/Nrf2/HO-1 Pathway in Fructose-Fed Diabetic Rats.
Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S.
Cardiovasc Drugs Ther. 2018 Apr;32(2):147-163. doi: 10.1007/s10557-018-6780-3.

Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.
Huang Y, Jiang H, Chen Y, Wang X, Yang Y, Tao J, Deng X, Liang G, Zhang H, Jiang W, Zhou R.
EMBO Mol Med. 2018 Apr;10(4). pii: e8689. doi: 10.15252/emmm.201708689.

Chronic Amyloid β Oligomer Infusion Evokes Sustained Inflammation and Microglial Changes in the Rat Hippocampus via NLRP3.
Fekete C, Vastagh C, Dénes Á, Hrabovszky E, Nyiri G, Kalló I, Liposits Z, Sárvári M.
Neuroscience. 2019 May 1;405:35-46. doi: 10.1016/j.neuroscience.2018.02.046. Epub 2018 Mar 6.

Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome.
Ding T, Wang S, Zhang X, Zai W, Fan J, Chen W, Bian Q, Luan J, Shen Y, Zhang Y, Ju D, Mei X.
Phytomedicine. 2018 Mar 1;41:45-53. doi: 10.1016/j.phymed.2018.01.026. Epub 2018 Jan 31.

Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications.
Sharma A, Tate M, Mathew G, Vince JE, Ritchie RH, de Haan JB.
Front Physiol. 2018 Feb 20;9:114. doi: 10.3389/fphys.2018.00114. eCollection 2018. Review.

Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes.
Birnbaum Y, Bajaj M, Yang HC, Ye Y.
Cardiovasc Drugs Ther. 2018 Apr;32(2):135-145. doi: 10.1007/s10557-018-6778-x.

Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets.
González-Mariscal I, Montoro RA, Doyle ME, Liu QR, Rouse M, O’Connell JF, Santa-Cruz Calvo S, Krzysik-Walker SM, Ghosh S, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Chia CW, Ghosh P, Egan JM.
Diabetologia. 2018 Jun;61(6):1470-1483. doi: 10.1007/s00125-018-4576-4. Epub 2018 Mar 1.

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice.
Zhai Y, Meng X, Ye T, Xie W, Sun G, Sun X.
Molecules. 2018 Feb 27;23(3). pii: E522. doi: 10.3390/molecules23030522.

Evidence against a role for NLRP3-driven islet inflammation in db/db mice.
Kammoun HL, Allen TL, Henstridge DC, Barre S, Coll RC, Lancaster GI, Cron L, Reibe S, Chan JY, Bensellam M, Laybutt DR, Butler MS, Robertson AAB, O’Neill LA, Cooper MA, Febbraio MA.
Mol Metab. 2018 Apr;10:66-73. doi: 10.1016/j.molmet.2018.02.001. Epub 2018 Feb 7.

Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis.
Han Y, Xu X, Tang C, Gao P, Chen X, Xiong X, Yang M, Yang S, Zhu X, Yuan S, Liu F, Xiao L, Kanwar YS, Sun L.
Redox Biol. 2018 Jun;16:32-46. doi: 10.1016/j.redox.2018.02.013. Epub 2018 Feb 15. Erratum in: Redox Biol. 2019 Jun;24:101216

Comparison of Inhibitory Capacities of 6-, 8- and 10-Gingerols/Shogaols on the Canonical NLRP3Inflammasome-Mediated IL-1β Secretion.
Ho SC, Chang YH.
Molecules. 2018 Feb 21;23(2). pii: E466. doi: 10.3390/molecules23020466.

Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice.
Lebeaupin C, Vallée D, Rousseau D, Patouraux S, Bonnafous S, Adam G, Luciano F, Luci C, Anty R, Iannelli A, Marchetti S, Kroemer G, Lacas-Gervais S, Tran A, Gual P, Bailly-Maitre B.
Hepatology. 2018 Aug;68(2):515-532. doi: 10.1002/hep.29847. Epub 2018 May 18.

Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes.
Gong T, Yang Y, Jin T, Jiang W, Zhou R.
Trends Immunol. 2018 May;39(5):393-406. doi: 10.1016/ Epub 2018 Feb 13. Review.

Enhanced Expression of NLRP3 Inflammasome-Related Inflammation in Diabetic Retinopathy.
Chen H, Zhang X, Liao N, Mi L, Peng Y, Liu B, Zhang S, Wen F.
Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):978-985. doi: 10.1167/iovs.17-22816.

Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice.
Pahwa R, Balderas M, Jialal I, Chen X, Luna RA, Devaraj S.
Diabetes Res. 2017;2017:6519785. doi: 10.1155/2017/6519785. Epub 2017 Dec 31.

The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy.
Chaurasia SS, Lim RR, Parikh BH, Wey YS, Tun BB, Wong TY, Luu CD, Agrawal R, Ghosh A, Mortellaro A, Rackoczy E, Mohan RR, Barathi VA.
Sci Rep. 2018 Feb 12;8(1):2847. doi: 10.1038/s41598-018-21198-z.

Metabolic/inflammatory/vascular comorbidity in psychiatric disorders; soluble epoxide hydrolase (sEH) as a possible new target.
Swardfager W, Hennebelle M, Yu D, Hammock BD, Levitt AJ, Hashimoto K, Taha AY.
Neurosci Biobehav Rev. 2018 Apr;87:56-66. doi: 10.1016/j.neubiorev.2018.01.010. Epub 2018 Feb 2. Review.

[Regulation of the NLRP3 inflammasome].
Groslambert M, Py BF.
Med Sci (Paris). 2018 Jan;34(1):47-53. doi: 10.1051/medsci/20183401013. Epub 2018 Jan 31. Review. French. 

The Role of Txnip in Mitophagy Dysregulation and Inflammasome Activation in Diabetic Retinopathy: A New Perspective.
Singh LP, Devi TS, Yumnamcha T.
JOJ Ophthalmol. 2017;4(4). pii: 555643. doi: 10.19080/jojo.2017.04.555643. Epub 2017 Sep 15.

Matrine suppresses AGE-induced HAEC injury by inhibiting ROS-mediated NRLP3 inflammasome activation.
Zhang Y, Yang X, Qiu C, Liu F, Liu P, Liu Z.
Eur J Pharmacol. 2018 Mar 5;822:207-211. doi: 10.1016/j.ejphar.2018.01.029. Epub 2018 Jan 31.

Micro-ribonucleic acid-binding site variants of type 2 diabetes candidate loci predispose to gestational diabetes mellitus in Chinese Han women.
Wang X, Li W, Ma L, Ping F, Liu J, Wu X, Mao J, Wang X, Nie M.
Diabetes Investig. 2018 Sep;9(5):1196-1202. doi: 10.1111/jdi.12803. Epub 2018 Mar 2.

The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways.
Jiang D, Chen S, Sun R, Zhang X, Wang D.
Cancer Lett. 2018 Apr 10;419:8-19. doi: 10.1016/j.canlet.2018.01.034. Epub 2018 Jan 12. Review.

IL-6 receptor blockade ameliorates diabetic nephropathy via inhibiting inflammasome in mice.
Wu R, Liu X, Yin J, Wu H, Cai X, Wang N, Qian Y, Wang F.
Metabolism. 2018 Jun;83:18-24. doi: 10.1016/j.metabol.2018.01.002. Epub 2018 Jan 12.

Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome.
Baldwin AG, Tapia VS, Swanton T, White CS, Beswick JA, Brough D, Freeman S.
ChemMedChem. 2018 Feb 20;13(4):312-320. doi: 10.1002/cmdc.201700731. Epub 2018 Feb 5.

Mitophagic Flux Deregulation, Lysosomal Destabilization and NLRP3 Inflammasome Activation in Diabetic Retinopathy: Potentials of Gene Therapy Targeting TXNIP and The Redox System.
Singh LP, Yumnamcha T, Swornalata Devi T.
Ophthalmol Res Rep. 2018;3(1). pii: ORRT-126. Epub 2018 Mar 12.

Hypoxia potentiates LPS-induced inflammatory response and increases cell death by promoting NLRP3 inflammasome activation in pancreatic β cells.
Chen C, Ma X, Yang C, Nie W, Zhang J, Li H, Rong P, Yi S, Wang W.
Biochem Biophys Res Commun. 2018 Jan 22;495(4):2512-2518. doi: 10.1016/j.bbrc.2017.12.134. Epub 2017 Dec 24.

Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation.
Liu Q, Zhang F, Zhang X, Cheng R, Ma JX, Yi J, Li J.
Mol Cell Biochem. 2018 Aug;445(1-2):105-115. doi: 10.1007/s11010-017-3256-x. Epub 2017 Dec 21.

Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1β on White Adipocyte Browning.
Okla M, Zaher W, Alfayez M, Chung S.
Inflammation. 2018 Mar;41(2):626-642. doi: 10.1007/s10753-017-0718-y.

Mitochondria, the NLRP3 Inflammasome, and Sirtuins in Type 2 Diabetes: New Therapeutic Targets.
Rovira-Llopis S, Apostolova N, Bañuls C, Muntané J, Rocha M, Victor VM.
Antioxid Redox Signal. 2018 Sep 10;29(8):749-791. doi: 10.1089/ars.2017.7313. Epub 2018 Jan 30. Review.

Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis.
Guo W, Liu W, Chen Z, Gu Y, Peng S, Shen L, Shen Y, Wang X, Feng GS, Sun Y, Xu Q.
Nat Commun. 2017 Dec 18;8(1):2168. doi: 10.1038/s41467-017-02351-0.

Lithium + Colchicine: A Potential Strategy to Reduce Pro-inflammatory Effects of Lithium Treatment.
Mooney JJ, Brady RO.
J Clin Psychopharmacol. 2018 Feb;38(1):80-85. doi: 10.1097/JCP.0000000000000830. Review.

Activation of NLRP3 Inflammasome by Advanced Glycation End Products Promotes Pancreatic Islet Damage.
Kong X, Lu AL, Yao XM, Hua Q, Li XY, Qin L, Zhang HM, Meng GX, Su Q.
Oxid Med Cell Longev. 2017;2017:9692546. doi: 10.1155/2017/9692546. Epub 2017 Nov 5.

Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases.
Liu D, Zeng X, Li X, Mehta JL, Wang X.
Basic Res Cardiol. 2017 Dec 9;113(1):5. doi: 10.1007/s00395-017-0663-9. Print 2018 Jan 8. Review.

Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3inflammasomes.
Lv ZH, Phuong TA, Jin SJ, Li XX, Xu M.
Oncotarget. 2017 Aug 24;8(53):91291-91305. doi: 10.18632/oncotarget.20443. eCollection 2017 Oct 31.

Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes.
Chen L, Liu C, Gao J, Xie Z, Chan LWC, Keating DJ, Yang Y, Sun J, Zhou F, Wei Y, Men X, Yang S.
Oncotarget. 2017 Sep 16;8(53):90693-90705. doi: 10.18632/oncotarget.20963. eCollection 2017 Oct 31.

Red raspberries suppress NLRP3 inflammasome and attenuate metabolic abnormalities in diet-induced obese mice.
Zhu MJ, Kang Y, Xue Y, Liang X, García MPG, Rodgers D, Kagel DR, Du M.
J Nutr Biochem. 2018 Mar;53:96-103. doi: 10.1016/j.jnutbio.2017.10.012. Epub 2017 Nov 2.

Heparan sulfate inhibits inflammation and improves wound healing by downregulating the NLR family pyrin domain containing 3 (NLRP3) inflammasome in diabetic rats.
Wang T, Zhao J, Zhang J, Mei J, Shao M, Pan Y, Yang W, Jiang Y, Liu F, Jia W.
Diabetes. 2018 Jul;10(7):556-563. doi: 10.1111/1753-0407.12630. Epub 2018 Jan 5.

The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP release.
Mugisho OO, Green CR, Kho DT, Zhang J, Graham ES, Acosta ML, Rupenthal ID.
Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):385-393. doi: 10.1016/j.bbagen.2017.11.015. Epub 2017 Nov 21.

Study of the NLRP3 inflammasome component genes and downstream cytokines in patients with type 2 diabetes mellitus with carotid atherosclerosis.
Lee J, Wan J, Lee L, Peng C, Xie H, Lee C.
Lipids Health Dis. 2017 Nov 18;16(1):217. doi: 10.1186/s12944-017-0595-2.

AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging.
Cordero MD, Williams MR, Ryffel B.
Trends Endocrinol Metab. 2018 Jan;29(1):8-17. doi: 10.1016/j.tem.2017.10.009. Epub 2017 Nov 14. Review.

Locus and gene-based GWAS meta-analysis identifies new diabetic nephropathy genes.
Saeed M.
Immunogenetics. 2018 Jun;70(6):347-353. doi: 10.1007/s00251-017-1044-0. Epub 2017 Nov 16 

Deactivation of the NLRP3 inflammasome in infiltrating macrophages by duodenal-jejunal bypass surgery mediates improvement of beta cell function in type 2 diabetes.
Wu D, Yan ZB, Cheng YG, Zhong MW, Liu SZ, Zhang GY, Hu SY.
Metabolism. 2018 Apr;81:1-12. doi: 10.1016/j.metabol.2017.10.015. Epub 2017 Nov 10.

Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling.
Deng X, Huang W, Peng J, Zhu TT, Sun XL, Zhou XY, Yang H, Xiong JF, He HQ, Xu YH, He YZ.
Inflammation. 2018 Feb;41(1):260-275. doi: 10.1007/s10753-017-0685-3.

Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats.
Sun X, Hao H, Han Q, Song X, Liu J, Dong L, Han W, Mu Y.
Stem Cell Res Ther. 2017 Nov 2;8(1):241. doi: 10.1186/s13287-017-0668-1.

Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance.
Su WJ, Peng W, Gong H, Liu YZ, Zhang Y, Lian YJ, Cao ZY, Wu R, Liu LL, Wang B, Wang YX, Jiang CL.
J Neuroinflammation. 2017 Oct 30;14(1):210. doi: 10.1186/s12974-017-0985-4.

Inflammasomes and type 2 diabetes: An updated systematic review.
Sepehri Z, Kiani Z, Afshari M, Kohan F, Dalvand A, Ghavami S.
Immunol Lett. 2017 Dec;192:97-103. doi: 10.1016/j.imlet.2017.10.010. Epub 2017 Oct 24. Review.

NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats.
Qiu Z, Lei S, Zhao B, Wu Y, Su W, Liu M, Meng Q, Zhou B, Leng Y, Xia ZY.
Oxid Med Cell Longev. 2017;2017:9743280. doi: 10.1155/2017/9743280. Epub 2017 Sep 14.

FL-926-16, a novel bioavailable carnosinase-resistant carnosine derivative, prevents onset and stops progression of diabetic nephropathy in db/db mice.
Iacobini C, Menini S, Blasetti Fantauzzi C, Pesce CM, Giaccari A, Salomone E, Lapolla A, Orioli M, Aldini G, Pugliese G.
Br J Pharmacol. 2018 Jan;175(1):53-66. doi: 10.1111/bph.14070. Epub 2017 Dec 8.

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders.
Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W, Deng X, Zhou R.
J Exp Med. 2017 Nov 6;214(11):3219-3238. doi: 10.1084/jem.20171419. Epub 2017 Oct 11.

H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation.
Zhang X, Pan L, Yang K, Fu Y, Liu Y, Chi J, Zhang X, Hong S, Ma X, Yin X.
Cell Physiol Biochem. 2017;43(4):1311-1324. doi: 10.1159/000481843. Epub 2017 Oct 9.

Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes.
Szpigel A, Hainault I, Carlier A, Venteclef N, Batto AF, Hajduch E, Bernard C, Ktorza A, Gautier JF, Ferré P, Bourron O, Foufelle F.
Diabetologia. 2018 Feb;61(2):399-412. doi: 10.1007/s00125-017-4462-5. Epub 2017 Oct 7.

Neutrophil microparticle production and inflammasome activation by hyperglycemia due to cytoskeletal instability.
Thom SR, Bhopale VM, Yu K, Huang W, Kane MA, Margolis DJ.
J Biol Chem. 2017 Nov 3;292(44):18312-18324. doi: 10.1074/jbc.M117.802629. Epub 2017 Sep 25.

Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion viaTranscription Factor EB in Human Monocytic Cells.
Tseng HHL, Vong CT, Kwan YW, Lee SM, Hoi MPM.
Front Immunol. 2017 Sep 15;8:1161. doi: 10.3389/fimmu.2017.01161. eCollection 2017 

Methylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation.
Ahn H, Kang SG, Yoon SI, Ko HJ, Kim PH, Hong EJ, An BS, Lee E, Lee GS.
Sci Rep. 2017 Sep 29;7(1):12409. doi: 10.1038/s41598-017-12635-6.

Weighted Gene Co-Expression Network Analysis Identifies Gender Specific Modules and Hub Genes Related to Metabolism and Inflammation in Response to an Acute Lipid Challenge.
Fatima A, Connaughton RM, Weiser A, Murphy AM, O’Grada C, Ryan M, Brennan L, O’Gaora P, Roche HM.
Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700388. Epub 2017 Dec 11.

Oleanolic acid alleviates diabetic rat carotid artery injury through the inhibition of NLRP3inflammasome signaling pathways.
An Q, Hu Q, Wang B, Cui W, Wu F, Ding Y.
Mol Med Rep. 2017 Dec;16(6):8413-8419. doi: 10.3892/mmr.2017.7594. Epub 2017 Sep 25.

Boron-Based Inhibitors of the NLRP3 Inflammasome.
Baldwin AG, Rivers-Auty J, Daniels MJD, White CS, Schwalbe CH, Schilling T, Hammadi H, Jaiyong P, Spencer NG, England H, Luheshi NM, Kadirvel M, Lawrence CB, Rothwell NJ, Harte MK, Bryce RA, Allan SM, Eder C, Freeman S, Brough D.
Cell Chem Biol. 2017 Nov 16;24(11):1321-1335.e5. doi: 10.1016/j.chembiol.2017.08.011. Epub 2017 Sep 21.

Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages.
Lee DW, Shin HY, Jeong JH, Han J, Ryu S, Nakahira K, Moon JS.
Biochem Biophys Res Commun. 2017 Nov 18;493(2):957-963. doi: 10.1016/j.bbrc.2017.09.111. Epub 2017 Sep 21.

Aldose Reductase Mediates NLRP3 Inflammasome-Initiated Innate Immune Response in Hyperglycemia-Induced Thp1 Monocytes and Male Mice.
Pal PB, Sonowal H, Shukla K, Srivastava SK, Ramana KV.
Endocrinology. 2017 Oct 1;158(10):3661-3675. doi: 10.1210/en.2017-00294.

Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy.
Garibotto G, Carta A, Picciotto D, Viazzi F, Verzola D.
J Nephrol. 2017 Dec;30(6):719-727. doi: 10.1007/s40620-017-0432-8. Epub 2017 Sep 20. Review.

Wu-Mei-Wan Reduces Insulin Resistance via Inhibition of NLRP3 Inflammasome Activation in HepG2 Cells.
Yang X, Li L, Fang K, Dong R, Li J, Zhao Y, Dong H, Yi P, Huang Z, Chen G, Lu F.
Evid Based Complement Alternat Med. 2017;2017:7283241. doi: 10.1155/2017/7283241. Epub 2017 Aug 27.

ROS-activated NLRP3 inflammasome initiates inflammation in delayed wound healing in diabetic rats.
Dai J, Zhang X, Wang Y, Chen H, Chai Y.
Int J Clin Exp Pathol. 2017 Sep 1;10(9):9902-9909. eCollection 2017.

Autophagy Inhibition Contributes to ROS-Producing NLRP3-Dependent Inflammasome Activation and Cytokine Secretion in High Glucose-Induced Macrophages.
Dai J, Zhang X, Li L, Chen H, Chai Y.
Cell Physiol Biochem. 2017;43(1):247-256. doi: 10.1159/000480367. Epub 2017 Aug 30.

PPARα Agonist Stimulated Angiogenesis by Improving Endothelial Precursor Cell Function Via a NLRP3 Inflammasome Pathway.
Deng Y, Han X, Yao Z, Sun Y, Yu J, Cai J, Ren G, Jiang G, Han F.
Cell Physiol Biochem. 2017;42(6):2255-2266. doi: 10.1159/000479999. Epub 2017 Aug 16.

Inhibition of TLR4 alleviates the inflammation and apoptosis of retinal ganglion cells in high glucose.
Hu L, Yang H, Ai M, Jiang S.
Graefes Arch Clin Exp Ophthalmol. 2017 Nov;255(11):2199-2210. doi: 10.1007/s00417-017-3772-0. Epub 2017 Aug 14.

Function of NLRP3 in the Pathogenesis and Development of Diabetic Nephropathy.
Fu Y, Wu N, Zhao D.
Med Sci Monit. 2017 Aug 11;23:3878-3884.

NLRP3 Inflammasome as a Molecular Marker in Diabetic Cardiomyopathy.
Luo B, Huang F, Liu Y, Liang Y, Wei Z, Ke H, Zeng Z, Huang W, He Y.
Front Physiol. 2017 Jul 25;8:519. doi: 10.3389/fphys.2017.00519. eCollection 2017. Review.

PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.
Spalinger MR, Lang S, Gottier C, Dai X, Rawlings DJ, Chan AC, Rogler G, Scharl M.
Autophagy. 2017 Sep 2;13(9):1590-1601. doi: 10.1080/15548627.2017.1341453. Epub 2017 Aug 8.

Downregulated NLRP3 and NLRP1 inflammasomes signaling pathways in the development and progression of type 1 diabetes mellitus.
Liu H, Xu R, Kong Q, Liu J, Yu Z, Zhao C.
Biomed Pharmacother. 2017 Oct;94:619-626. doi: 10.1016/j.biopha.2017.07.102. Epub 2017 Aug 4.

Banxia-houpu decoction restores glucose intolerance in CUMS rats through improvement of insulin signaling and suppression of NLRP3 inflammasome activation in liver and brain.
Jia KK, Zheng YJ, Zhang YX, Liu JH, Jiao RQ, Pan Y, Kong LD.
J Ethnopharmacol. 2017 Sep 14;209:219-229. doi: 10.1016/j.jep.2017.08.004. Epub 2017 Aug 4.

Implication of REDD1 in the activation of inflammatory pathways.
Pastor F, Dumas K, Barthélémy MA, Regazzetti C, Druelle N, Peraldi P, Cormont M, Tanti JF, Giorgetti-Peraldi S.
Sci Rep. 2017 Aug 1;7(1):7023. doi: 10.1038/s41598-017-07182-z.

T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders.
Rani J, Mittal I, Pramanik A, Singh N, Dube N, Sharma S, Puniya BL, Raghunandanan MV, Mobeen A, Ramachandran S.
Sci Rep. 2017 Jul 31;7(1):6892. doi: 10.1038/s41598-017-07238-0.

Identification and validation of uterine stimulant methylergometrine as a potential inhibitor of caspase-1 activation.
García-Laínez G, Sancho M, García-Bayarri V, Orzáez M.
Apoptosis. 2017 Oct;22(10):1310-1318. doi: 10.1007/s10495-017-1405-z.

A Protective Role of Glibenclamide in Inflammation-Associated Injury.
Zhang G, Lin X, Zhang S, Xiu H, Pan C, Cui W.
Mediators Inflamm. 2017;2017:3578702. doi: 10.1155/2017/3578702. Epub 2017 Jun 27. Review.

The Role of Exogenous Hydrogen Sulfide in Free Fatty Acids Induced Inflammation in Macrophages.
Luo ZL, Ren JD, Huang Z, Wang T, Xiang K, Cheng L, Tang LJ.
Cell Physiol Biochem. 2017;42(4):1635-1644. doi: 10.1159/000479405. Epub 2017 Jul 24.

Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction.
Zhang Y, Lv X, Hu Z, Ye X, Zheng X, Ding Y, Xie P, Liu Q.
Cell Death Dis. 2017 Jul 20;8(7):e2941. doi: 10.1038/cddis.2017.308.

Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation.
Wang S, Li Y, Fan J, Zhang X, Luan J, Bian Q, Ding T, Wang Y, Wang Z, Song P, Cui D, Mei X, Ju D.
Cell Death Dis. 2017 Jul 20;8(7):e2937. doi: 10.1038/cddis.2017.292.

Nutritional modulation of metabolic inflammation.
Kirwan AM, Lenighan YM, O’Reilly ME, McGillicuddy FC, Roche HM.
Biochem Soc Trans. 2017 Aug 15;45(4):979-985. doi: 10.1042/BST20160465. Epub 2017 Jul 14. Review.

Pioglitazone ameliorates glomerular NLRP3 inflammasome activation in apolipoprotein E knockout mice with diabetes mellitus.
Wang Y, Yu B, Wang L, Yang M, Xia Z, Wei W, Zhang F, Yuan X.
PLoS One. 2017 Jul 14;12(7):e0181248. doi: 10.1371/journal.pone.0181248. eCollection 2017.

Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors.
Hill JR, Coll RC, Sue N, Reid JC, Dou J, Holley CL, Pelingon R, Dickinson JB, Biden TJ, Schroder K, Cooper MA, Robertson AAB.
ChemMedChem. 2017 Sep 7;12(17):1449-1457. doi: 10.1002/cmdc.201700270. Epub 2017 Aug 4.

Can Serum Uric Acid Lowering Therapy Contribute to the Prevention or Treatment of Nonalcoholic Fatty Liver Disease?
Paschos P, Athyros VG, Tsimperidis A, Katsoula A, Grammatikos N, Giouleme O.
Curr Vasc Pharmacol. 2018;16(3):269-275. doi: 10.2174/1570161115666170621082237. Review.

Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge.
Song E, Jahng JW, Chong LP, Sung HK, Han M, Luo C, Wu D, Boo S, Hinz B, Cooper MA, Robertson AA, Berger T, Mak TW, George I, Schulze PC, Wang Y, Xu A, Sweeney G.
Am J Transl Res. 2017 Jun 15;9(6):2723-2735. eCollection 2017.

Deletion of TXNIP Mitigates High-Fat Diet-Impaired Angiogenesis and Prevents Inflammation in a Mouse Model of Critical Limb Ischemia.
Elshaer SL, Mohamed IN, Coucha M, Altantawi S, Eldahshan W, Bartasi ML, Shanab AY, Lorys R, El-Remessy AB.
Antioxidants (Basel). 2017 Jun 29;6(3). pii: E47. doi: 10.3390/antiox6030047.

Ablation of Neuropilin 1 in Myeloid Cells Exacerbates High-Fat Diet-Induced Insulin Resistance Through Nlrp3 Inflammasome In Vivo.
Dai X, Okon I, Liu Z, Bedarida T, Wang Q, Ramprasath T, Zhang M, Song P, Zou MH.
Diabetes. 2017 Sep;66(9):2424-2435. doi: 10.2337/db17-0132. Epub 2017 Jun 28.

Gain-of-function SNPs in NLRP3 and IL1B genes confer protection against obesity and T2D: undiscovered role of inflammasome genetics in metabolic homeostasis?
de Moraes Rodrigues J, Souza de Lima D, Leal VNC, Bosco AA, Sandrim V, Pontillo A.
Endocrine. 2018 May;60(2):368-371. doi: 10.1007/s12020-017-1343-0. Epub 2017 Jun 20. No abstract available. 

NLRP3 expression and urinary HSP72 in relation to biomarkers of inflammation and oxidative stress in diabetic nephropathy patients.
El-Horany HE, Abd-Ellatif RN, Watany M, Hafez YM, Okda HI.
IUBMB Life. 2017 Aug;69(8):623-630. doi: 10.1002/iub.1645. Epub 2017 Jun 20.

Metabolic injury-induced NLRP3 inflammasome activation dampens phospholipid degradation.
Rampanelli E, Orsó E, Ochodnicky P, Liebisch G, Bakker PJ, Claessen N, Butter LM, van den Bergh Weerman MA, Florquin S, Schmitz G, Leemans JC.
Sci Rep. 2017 Jun 6;7(1):2861. doi: 10.1038/s41598-017-01994-9.

Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs).
Kinnunen K, Piippo N, Loukovaara S, Hytti M, Kaarniranta K, Kauppinen A.
J Cell Commun Signal. 2017 Sep;11(3):275-279. doi: 10.1007/s12079-017-0396-4. Epub 2017 May 25.

Activation of NLRP3 Inflammasome in Inflammatory Bowel Disease: Differences Between Crohn’s Disease and Ulcerative Colitis.
Lazaridis LD, Pistiki A, Giamarellos-Bourboulis EJ, Georgitsi M, Damoraki G, Polymeros D, Dimitriadis GD, Triantafyllou K.
Dig Dis Sci. 2017 Sep;62(9):2348-2356. doi: 10.1007/s10620-017-4609-8. Epub 2017 May 18.

The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation.
Kulak K, Westermark GT, Papac-Milicevic N, Renström E, Blom AM, King BC.
Diabetologia. 2017 Aug;60(8):1522-1533. doi: 10.1007/s00125-017-4286-3. Epub 2017 May 12.

Effect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome.
Kim DH, Kim SM, Lee B, Lee EK, Chung KW, Moon KM, An HJ, Kim KM, Yu BP, Chung HY.
J Nutr Biochem. 2017 Jul;45:104-114. doi: 10.1016/j.jnutbio.2017.04.014. Epub 2017 Apr 22.

Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway.
Yin Y, Chen F, Wang W, Wang H, Zhang X.
Mol Vis. 2017 Apr 14;23:242-250. eCollection 2017.

SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor.
Ye Y, Bajaj M, Yang HC, Perez-Polo JR, Birnbaum Y.
Cardiovasc Drugs Ther. 2017 Apr;31(2):119-132. doi: 10.1007/s10557-017-6725-2.

Metaflammation: Tissue-Specific Alterations of the NLRP3 Inflammasome Platform in Metabolic Syndrome.
Mastrocola R, Aragno M, Alloatti G, Collino M, Penna C, Pagliaro P.
Curr Med Chem. 2018;25(11):1294-1310. doi: 10.2174/0929867324666170407123522. Review.

The P2X7 Receptor-Interleukin-1 Liaison.
Giuliani AL, Sarti AC, Falzoni S, Di Virgilio F.
Front Pharmacol. 2017 Mar 16;8:123. doi: 10.3389/fphar.2017.00123. eCollection 2017. Review.

An excessive increase in glutamate contributes to glucose-toxicity in β-cells via activation of pancreatic NMDA receptors in rodent diabetes.
Huang XT, Li C, Peng XP, Guo J, Yue SJ, Liu W, Zhao FY, Han JZ, Huang YH, Yang-Li, Cheng QM, Zhou ZG, Chen C, Feng DD, Luo ZQ.
Sci Rep. 2017 Mar 17;7:44120. doi: 10.1038/srep44120.

The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3inflammasome.
Haneklaus M, O’Neil JD, Clark AR, Masters SL, O’Neill LAJ.
J Biol Chem. 2017 Apr 28;292(17):6869-6881. doi: 10.1074/jbc.M116.772947. Epub 2017 Mar 16.

Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model.
Carlos D, Costa FR, Pereira CA, Rocha FA, Yaochite JN, Oliveira GG, Carneiro FS, Tostes RC, Ramos SG, Zamboni DS, Camara NO, Ryffel B, Silva JS.
Front Immunol. 2017 Feb 27;8:164. doi: 10.3389/fimmu.2017.00164. eCollection 2017.

Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse.
Ye X, Shen T, Hu J, Zhang L, Zhang Y, Bao L, Cui C, Jin G, Zan K, Zhang Z, Yang X, Shi H, Zu J, Yu M, Song C, Wang Y, Qi S, Cui G.
Exp Neurol. 2017 Jun;292:46-55. doi: 10.1016/j.expneurol.2017.03.002. Epub 2017 Mar 6.

NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy.
Loukovaara S, Piippo N, Kinnunen K, Hytti M, Kaarniranta K, Kauppinen A.
Acta Ophthalmol. 2017 Dec;95(8):803-808. doi: 10.1111/aos.13427. Epub 2017 Mar 8.

High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress.
Coucha M, Mohamed IN, Elshaer SL, Mbata O, Bartasis ML, El-Remessy AB.
World J Diabetes. 2017 Feb 15;8(2):56-65. doi: 10.4239/wjd.v8.i2.56.

Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis.
Cannito S, Morello E, Bocca C, Foglia B, Benetti E, Novo E, Chiazza F, Rogazzo M, Fantozzi R, Povero D, Sutti S, Bugianesi E, Feldstein AE, Albano E, Collino M, Parola M.
PLoS One. 2017 Mar 1;12(3):e0172575. doi: 10.1371/journal.pone.0172575. eCollection 2017 

Advanced glycation end products regulate anabolic and catabolic activities via NLRP3-inflammasome activation in human nucleus pulposus cells.
Song Y, Wang Y, Zhang Y, Geng W, Liu W, Gao Y, Li S, Wang K, Wu X, Kang L, Yang C.
J Cell Mol Med. 2017 Jul;21(7):1373-1387. doi: 10.1111/jcmm.13067. Epub 2017 Feb 22.

A novel mechanism of diabetic vascular endothelial dysfunction: Hypoadiponectinemia-induced NLRP3 inflammasome activation.
Zhang J, Xia L, Zhang F, Zhu D, Xin C, Wang H, Zhang F, Guo X, Lee Y, Zhang L, Wang S, Guo X, Huang C, Gao F, Liu Y, Tao L.
Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1556-1567. doi: 10.1016/j.bbadis.2017.02.012. Epub 2017 Feb 13.

Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling.
Lu M, Yin N, Liu W, Cui X, Chen S, Wang E.
Biomed Res Int. 2017;2017:1516985. doi: 10.1155/2017/1516985. Epub 2017 Jan 17.

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.
Mridha AR, Wree A, Robertson AAB, Yeh MM, Johnson CD, Van Rooyen DM, Haczeyni F, Teoh NC, Savard C, Ioannou GN, Masters SL, Schroder K, Cooper MA, Feldstein
AE, Farrell GC.
J Hepatol. 2017 May;66(5):1037-1046. doi: 10.1016/j.jhep.2017.01.022. Epub 2017 Feb 3.

NLRP3 Inflammasome Expression and Signaling in Human Diabetic Wounds and in High Glucose Induced Macrophages.
Zhang X, Dai J, Li L, Chen H, Chai Y.
Diabetes Res. 2017;2017:5281358. doi: 10.1155/2017/5281358. Epub 2017 Jan 10.

LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy.
Yi H, Peng R, Zhang LY, Sun Y, Peng HM, Liu HD, Yu LJ, Li AL, Zhang YJ, Jiang WH, Zhang Z.
Cell Death Dis. 2017 Feb 2;8(2):e2583. doi: 10.1038/cddis.2016.451.

Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9.
Rhoads JP, Lukens JR, Wilhelm AJ, Moore JL, Mendez-Fernandez Y, Kanneganti TD, Major AS.
J Immunol. 2017 Mar 1;198(5):2105-2114. doi: 10.4049/jimmunol.1601563. Epub 2017 Jan 27.

The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE-/-Mice.
Leng W, Ouyang X, Lei X, Wu M, Chen L, Wu Q, Deng W, Liang Z.
Mediators Inflamm. 2016;2016:6305735. doi: 10.1155/2016/6305735. Epub 2016 Dec 26.

Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation.
Dror E, Dalmas E, Meier DT, Wueest S, Thévenet J, Thienel C, Timper K, Nordmann TM, Traub S, Schulze F, Item F, Vallois D, Pattou F, Kerr-Conte J, Lavallard V, Berney T, Thorens B, Konrad D, Böni-Schnetzler M, Donath MY.
Nat Immunol. 2017 Mar;18(3):283-292. doi: 10.1038/ni.3659. Epub 2017 Jan 16.

Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders.
Gong T, Wang X, Yang Y, Yan Y, Yu C, Zhou R, Jiang W.
J Immunol. 2017 Mar 1;198(5):2082-2092. doi: 10.4049/jimmunol.1600145. Epub 2017 Jan 13.

Sterol Regulatory Element-Binding Protein-1c Regulates Inflammasome Activation in Gingival Fibroblasts Infected with High-Glucose-Treated Porphyromonas gingivalis.
Kuo HC, Chang LC, Chen TC, Lee KC, Lee KF, Chen CN, Yu HR.
Front Cell Infect Microbiol. 2016 Dec 26;6:195. doi: 10.3389/fcimb.2016.00195. eCollection 2016.

NLRP3 inflammasome: A therapeutic option for kidney disease?
Buelvas-Jiménez N, Suárez-Useche RJ, Vielma-Guevara JR.
Rev Salud Publica (Bogota). 2017 Jan-Feb;19(1):118-122. doi: 10.15446/rsap.v19n1.54415.

Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.
Lordén G, Sanjuán-García I, de Pablo N, Meana C, Alvarez-Miguel I, Pérez-García MT, Pelegrín P, Balsinde J, Balboa MA.
J Exp Med. 2017 Feb;214(2):511-528. doi: 10.1084/jem.20161452. Epub 2016 Dec 28.

Long noncoding RNA MALAT1 regulates renal tubular epithelial pyroptosis by modulated miR-23c targeting of ELAVL1 in diabetic nephropathy.
Li X, Zeng L, Cao C, Lu C, Lian W, Han J, Zhang X, Zhang J, Tang T, Li M.
Exp Cell Res. 2017 Jan 15;350(2):327-335. doi: 10.1016/j.yexcr.2016.12.006. Epub 2016 Dec 10.

The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome.
Traba J, Sack MN.
Cell Mol Life Sci. 2017 May;74(10):1777-1791. doi: 10.1007/s00018-016-2431-7. Epub 2016 Dec 10. Review.

Rutin protects endothelial dysfunction by disturbing Nox4 and ROS-sensitive NLRP3 inflammasome.
Wang W, Wu QH, Sui Y, Wang Y, Qiu X.
Biomed Pharmacother. 2017 Feb;86:32-40. doi: 10.1016/j.biopha.2016.11.134. Epub 2016 Dec 6.

Defective production of interleukin-1 beta in patients with type 2 diabetes mellitus: Restoration by proper glycemic control.
Kousathana F, Georgitsi M, Lambadiari V, Giamarellos-Bourboulis EJ, Dimitriadis G, Mouktaroudi M.
Cytokine. 2017 Feb;90:177-184. doi: 10.1016/j.cyto.2016.11.009. Epub 2016 Dec 3.

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice.
Monnerat G, Alarcón ML, Vasconcellos LR, Hochman-Mendez C, Brasil G, Bassani RA, Casis O, Malan D, Travassos LH, Sepúlveda M, Burgos JI, Vila-Petroff M, Dutra FF, Bozza MT, Paiva CN, Carvalho AB, Bonomo A, Fleischmann BK, de Carvalho ACC, Medei E.
Nat Commun. 2016 Nov 24;7:13344. doi: 10.1038/ncomms13344.

Thioredoxin-Interacting Protein Mediates NLRP3 Inflammasome Activation Involved in the Susceptibility to Ischemic Acute Kidney Injury in Diabetes.
Xiao YD, Huang YY, Wang HX, Wu Y, Leng Y, Liu M, Sun Q, Xia ZY.
Oxid Med Cell Longev. 2016;2016:2386068. Epub 2016 Oct 27.

Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via Adenosine.
Birnbaum Y, Birnbaum GD, Birnbaum I, Nylander S, Ye Y.
Cardiovasc Drugs Ther. 2016 Dec;30(6):539-550.

Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy.
Qiu YY, Tang LQ.
Pharmacol Res. 2016 Dec;114:251-264. doi: 10.1016/j.phrs.2016.11.004. Epub 2016 Nov 5. Review.

Mitochondria as a centrally positioned hub in the innate immune response.
Sandhir R, Halder A, Sunkaria A.
Biochim Biophys Acta Mol Basis Dis. 2017 May;1863(5):1090-1097. doi: 10.1016/j.bbadis.2016.10.020. Epub 2016 Oct 26. Review.

Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice.
Zhou F, Zhang Y, Chen J, Hu X, Xu Y.
Eur J Pharmacol. 2016 Nov 15;791:735-740. doi: 10.1016/j.ejphar.2016.10.016. Epub 2016 Oct 15.

Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline.
Chen W, Zhao M, Zhao S, Lu Q, Ni L, Zou C, Lu L, Xu X, Guan H, Zheng Z, Qiu Q.
Inflamm Res. 2017 Feb;66(2):157-166. doi: 10.1007/s00011-016-1002-6. Epub 2016 Oct 26.

Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction.
Chen Y, Wang L, Pitzer AL, Li X, Li PL, Zhang Y.
J Mol Med (Berl). 2016 Dec;94(12):1335-1347. doi: 10.1007/s00109-016-1481-5. Epub 2016 Oct 25.

Role of dietary fatty acids in liver injury caused by vinyl chloride metabolites in mice.
Anders LC, Yeo H, Kaelin BR, Lang AL, Bushau AM, Douglas AN, Cave M, Arteel GE, McClain CJ, Beier JI.
Toxicol Appl Pharmacol. 2016 Nov 15;311:34-41. doi: 10.1016/j.taap.2016.09.026. Epub 2016 Sep 28.

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome.
Guo C, Xie S, Chi Z, Zhang J, Liu Y, Zhang L, Zheng M, Zhang X, Xia D, Ke Y, Lu L, Wang D.
Immunity. 2016 Oct 18;45(4):802-816. doi: 10.1016/j.immuni.2016.09.008. Epub 2016 Sep 28. Erratum in: Immunity. 2016 Oct 18;45(4):944

TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells.
Tseng HH, Vong CT, Kwan YW, Lee SM, Hoi MP.
Sci Rep. 2016 Oct 12;6:35016. doi: 10.1038/srep35016.

Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy.
Shahzad K, Bock F, Al-Dabet MM, Gadi I, Nazir S, Wang H, Kohli S, Ranjan S, Mertens PR, Nawroth PP, Isermann B.
Sci Rep. 2016 Oct 10;6:34228. doi: 10.1038/srep34228.

Involvement of the NLRC4-Inflammasome in Diabetic Nephropathy.
Yuan F, Kolb R, Pandey G, Li W, Sun L, Liu F, Sutterwala FS, Liu Y, Zhang W.
PLoS One. 2016 Oct 5;11(10):e0164135. doi: 10.1371/journal.pone.0164135. eCollection 2016.

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Pancreatic Islets from Zucker Diabetic Fatty Rats.
Mocanu AO, Mulya A, Huang H, Dan O, Schauer PR, Dinischiotu A, Brethauer SA, Kirwan JP.
Obes Surg. 2016 Dec;26(12):3076-3081.

The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases.
Sayan M, Mossman BT.
Part Fibre Toxicol. 2016 Sep 20;13(1):51. doi: 10.1186/s12989-016-0162-4. Review.

[Interleukin-1, inflammasome and autoinflammatory diseases].
Jamilloux Y, Bourdonnay E, Gerfaud-Valentin M, Py BF, Lefeuvre L, Barba T, Broussolle C, Henry T, Sève P.
Rev Med Interne. 2018 Apr;39(4):233-239. doi: 10.1016/j.revmed.2016.07.007. Epub 2016 Sep 14. Review. French. 

Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance.
Yu JW, Lee MS.
Arch Pharm Res. 2016 Nov;39(11):1503-1518. Epub 2016 Sep 7. Review.

Dipeptidyl peptidase-4 inhibition by Saxagliptin prevents inflammation and renal injury by targeting the Nlrp3/ASC inflammasome.
Birnbaum Y, Bajaj M, Qian J, Ye Y.
BMJ Open Diabetes Res Care. 2016 Aug 4;4(1):e000227. doi: 10.1136/bmjdrc-2016-000227. eCollection 2016.

Inflammasome Activation in Chronic Glomerular Diseases.
Conley SM, Abais JM, Boini KM, Li PL.
Curr Drug Targets. 2017;18(9):1019-1029. doi: 10.2174/1389450117666160817103435. Review.

Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis.
Cinar R, Iyer MR, Liu Z, Cao Z, Jourdan T, Erdelyi K, Godlewski G, Szanda G, Liu J, Park JK, Mukhopadhyay B, Rosenberg AZ, Liow JS, Lorenz RG, Pacher P, Innis RB, Kunos G.
JCI Insight. 2016 Jul 21;1(11). pii: 87336. doi: 10.1172/jci.insight.87336.

Inflammasomes link vascular disease with neuroinflammation and brain disorders.
Lénárt N, Brough D, Dénes Á.
J Cereb Blood Flow Metab. 2016 Oct;36(10):1668-1685. Epub 2016 Aug 2. Review.

Autophagy resolves early retinal inflammation in Igf1-deficient mice.
Arroba AI, Rodríguez-de la Rosa L, Murillo-Cuesta S, Vaquero-Villanueva L, Hurlé JM, Varela-Nieto I, Valverde ÁM.
Dis Model Mech. 2016 Sep 1;9(9):965-74. doi: 10.1242/dmm.026344. Epub 2016 Jul 21.

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.
Moon JS, Nakahira K, Chung KP, DeNicola GM, Koo MJ, Pabón MA, Rooney KT, Yoon JH, Ryter SW, Stout-Delgado H, Choi AM.
Nat Med. 2016 Sep;22(9):1002-12. doi: 10.1038/nm.4153. Epub 2016 Jul 25.

Ameliorative effect of dietary genistein on diabetes induced hyper-inflammation and oxidative stress during early stage of wound healing in alloxan induced diabetic mice.
Eo H, Lee HJ, Lim Y.
Biochem Biophys Res Commun. 2016 Sep 23;478(3):1021-7. doi: 10.1016/j.bbrc.2016.07.039. Epub 2016 Jul 16.

A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3inflammasome-mediated inflammation and improving insulin signaling.
Healy NP, Kirwan AM, McArdle MA, Holohan K, Nongonierma AB, Keane D, Kelly S, Celkova L, Lyons CL, McGillicuddy FC, Finucane OM, Murray BA, Kelly PM, Brennan L, FitzGerald RJ, Roche HM.
Mol Nutr Food Res. 2016 Nov;60(11):2421-2432. doi: 10.1002/mnfr.201501054. Epub 2016 Sep 8.

Obesity and Type 2 Diabetes Alters the Immune Properties of Human Adipose Derived Stem Cells.
Serena C, Keiran N, Ceperuelo-Mallafre V, Ejarque M, Fradera R, Roche K, Nuñez-Roa C, Vendrell J, Fernández-Veledo S.
Stem Cells. 2016 Oct;34(10):2559-2573. doi: 10.1002/stem.2429. Epub 2016 Jul 4.

Post-translational regulation of inflammasomes.
Yang J, Liu Z, Xiao TS.
Cell Mol Immunol. 2017 Jan;14(1):65-79. doi: 10.1038/cmi.2016.29. Epub 2016 Jun 27. Review.

Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice.
Li A, Zhang S, Li J, Liu K, Huang F, Liu B.
Mol Cell Endocrinol. 2016 Oct 15;434:36-47. doi: 10.1016/j.mce.2016.06.008. Epub 2016 Jun 6.

Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3inflammasome.
Samra YA, Said HS, Elsherbiny NM, Liou GI, El-Shishtawy MM, Eissa LA.
Life Sci. 2016 Jul 15;157:187-199. doi: 10.1016/j.lfs.2016.06.002. Epub 2016 Jun 3 

Juniperus rigida Sieb. extract inhibits inflammatory responses via attenuation of TRIF-dependent signaling and inflammasome activation.
Han JW, Shim DW, Shin WY, Kim MK, Shim EJ, Sun X, Koppula S, Kim TJ, Kang TB, Lee KH.
J Ethnopharmacol. 2016 Aug 22;190:91-9. doi: 10.1016/j.jep.2016.05.059. Epub 2016 May 31.

Colchicine to decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation.
Demidowich AP, Davis AI, Dedhia N, Yanovski JA.
Med Hypotheses. 2016 Jul;92:67-73. doi: 10.1016/j.mehy.2016.04.039. Epub 2016 Apr 25.

High Glucose and Lipopolysaccharide Activate NOD1- RICK-NF-κB Inflammatory Signaling in Mesangial Cells.
Huang W, Gou F, Long Y, Li Y, Feng H, Zhang Q, Gao C, Chen G, Xu Y.
Exp Clin Endocrinol Diabetes. 2016 Sep;124(8):512-517. Epub 2016 May 11.

Depot- and gender-specific expression of NLRP3 inflammasome and toll-like receptors in adipose tissue of cancer patients.
Shimabukuro M, Sato H, Izaki H, Fukuda D, Uematsu E, Hirata Y, Yagi S, Soeki T, Sakaue H, Kanayama HO, Masuzaki H, Sata M.
Biofactors. 2016 Jul 8;42(4):397-406. doi: 10.1002/biof.1287. Epub 2016 Apr 18.

Glutamine Modulates Macrophage Lipotoxicity.
He L, Weber KJ, Schilling JD.
Nutrients. 2016 Apr 12;8(4):215. doi: 10.3390/nu8040215.

Inhibition of the Inflammasome NLRP3 by Arglabin Attenuates Inflammation, Protects Pancreatic β-Cells from Apoptosis, and Prevents Type 2 Diabetes Mellitus Development in ApoE2Ki Mice on a Chronic High-Fat Diet.
Abderrazak A, El Hadri K, Bosc E, Blondeau B, Slimane MN, Büchele B, Simmet T, Couchie D, Rouis M.
J Pharmacol Exp Ther. 2016 Jun;357(3):487-94. doi: 10.1124/jpet.116.232934. Epub 2016 Apr 4 

The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes.
Tai N, Wong FS, Wen L.
J Autoimmun. 2016 Jul;71:26-34. doi: 10.1016/j.jaut.2016.03.006. Epub 2016 Mar 24. Review.

Disease-Induced Neuroinflammation and Depression.
Benatti C, Blom JM, Rigillo G, Alboni S, Zizzi F, Torta R, Brunello N, Tascedda F.
CNS Neurol Disord Drug Targets. 2016;15(4):414-33. Review.

Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation.
Souza AC, Bocharov AV, Baranova IN, Vishnyakova TG, Huang YG, Wilkins KJ, Hu X, Street JM, Alvarez-Prats A, Mullick AE, Patterson AP, Remaley AT, Eggerman TL, Yuen PS, Star RA.
Kidney Int. 2016 Apr;89(4):809-22. doi: 10.1016/j.kint.2015.12.043.

Design, Synthesis, and Evaluation of Acrylamide Derivatives as Direct NLRP3 Inflammasome Inhibitors.
Cocco M, Miglio G, Giorgis M, Garella D, Marini E, Costale A, Regazzoni L, Vistoli G, Orioli M, Massulaha-Ahmed R, Détraz-Durieux I, Groslambert M, Py BF, Bertinaria M.
ChemMedChem. 2016 Aug 19;11(16):1790-803. doi: 10.1002/cmdc.201600055. Epub 2016 Mar 17.

Cichorium intybus Linn. Extract Prevents Type 2 Diabetes Through Inhibition of NLRP3Inflammasome Activation.
Shim DW, Han JW, Ji YE, Shin WY, Koppula S, Kim MK, Kim TK, Park PJ, Kang TB, Lee KH.
J Med Food. 2016 Mar;19(3):310-7. doi: 10.1089/jmf.2015.3556.

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis.
Iannitti RG, Napolioni V, Oikonomou V, De Luca A, Galosi C, Pariano M, Massi-Benedetti C, Borghi M, Puccetti M, Lucidi V, Colombo C, Fiscarelli E, Lass-Flörl C, Majo F, Cariani L, Russo M, Porcaro L, Ricciotti G, Ellemunter H, Ratclif L, De Benedictis FM, Talesa VN, Dinarello CA, van de Veerdonk FL, Romani L.
Nat Commun. 2016 Mar 14;7:10791. doi: 10.1038/ncomms10791.

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells.
Robblee MM, Kim CC, Porter Abate J, Valdearcos M, Sandlund KL, Shenoy MK, Volmer R, Iwawaki T, Koliwad SK.
Cell Rep. 2016 Mar 22;14(11):2611-23. doi: 10.1016/j.celrep.2016.02.053. Epub 2016 Mar 10.

Association of a variable number tandem repeat in the NLRP3 gene in women with susceptibility to RVVC.
Jaeger M, Carvalho A, Cunha C, Plantinga TS, van de Veerdonk F, Puccetti M, Galosi C, Joosten LA, Dupont B, Kullberg BJ, Sobel JD, Romani L, Netea MG.
Eur J Clin Microbiol Infect Dis. 2016 May;35(5):797-801. doi: 10.1007/s10096-016-2600-5. Epub 2016 Mar 7.

Regulation of the clock gene expression in human adipose tissue by weight loss.
Pivovarova O, Gögebakan Ö, Sucher S, Groth J, Murahovschi V, Kessler K, Osterhoff M, Rudovich N, Kramer A, Pfeiffer AF.
Int J Obes (Lond). 2016 Jun;40(6):899-906. doi: 10.1038/ijo.2016.34. Epub 2016 Feb 23.

Inflammasome as a New Therapeutic Target for Diabetic Complications.
Volpe CM, Anjos PM, Nogueira-Machado JA.
Recent Pat Endocr Metab Immune Drug Discov. 2016;10(1):56-62. Review.

MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1.
Jeyabal P, Thandavarayan RA, Joladarashi D, Suresh Babu S, Krishnamurthy S, Bhimaraj A, Youker KA, Kishore R, Krishnamurthy P.
Biochem Biophys Res Commun. 2016 Mar 18;471(4):423-9. doi: 10.1016/j.bbrc.2016.02.065. Epub 2016 Feb 17.

Relationship of endothelin-1 and NLRP3 inflammasome activation in HT22 hippocampal cells in diabetes.
Ward R, Ergul A.
Life Sci. 2016 Aug 15;159:97-103. doi: 10.1016/j.lfs.2016.02.043. Epub 2016 Feb 13.

High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells.
Feng H, Gu J, Gou F, Huang W, Gao C, Chen G, Long Y, Zhou X, Yang M, Liu S, Lü S, Luo Q, Xu Y.
Diabetes Res. 2016;2016:6973175. doi: 10.1155/2016/6973175. Epub 2016 Jan 5.

Upregulation of inflammasome activity and increased gut permeability are associated with obesity in children and adolescents.
Rainone V, Schneider L, Saulle I, Ricci C, Biasin M, Al-Daghri NM, Giani E, Zuccotti GV, Clerici M, Trabattoni D.
Int J Obes (Lond). 2016 Jun;40(6):1026-33. doi: 10.1038/ijo.2016.26. Epub 2016 Feb 15.

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy.
Shahzad K, Bock F, Al-Dabet MM, Gadi I, Kohli S, Nazir S, Ghosh S, Ranjan S, Wang H, Madhusudhan T, Nawroth PP, Isermann B.
J Am Soc Nephrol. 2016 Aug;27(8):2270-5. doi: 10.1681/ASN.2015060676. Epub 2016 Feb 1 

Activation of the dsRNA-Activated Protein Kinase PKR in Mitochondrial Dysfunction and Inflammatory Stress in Metabolic Syndrome.
Sud N, Rutledge AC, Pan K, Su Q.
Curr Pharm Des. 2016;22(18):2697-703. Review.

Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice.
Mardare C, Krüger K, Liebisch G, Seimetz M, Couturier A, Ringseis R, Wilhelm J, Weissmann N, Eder K, Mooren FC.
Diabetes Res. 2016;2016:4536470. doi: 10.1155/2016/4536470. Epub 2015 Dec 14.

Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates.
Westwell-Roper C, Denroche HC, Ehses JA, Verchere CB.
J Biol Chem. 2016 Apr 22;291(17):8908-17. doi: 10.1074/jbc.M115.712455. Epub 2016 Jan 19.

Investigation into the association between NLRP3 gene polymorphisms and susceptibility to type 2 diabetes mellitus.
Wang S, Fang F, Jin WB, Wang X, Zheng XS.
Genet Mol Res. 2015 Dec 21;14(4):17447-52. doi: 10.4238/2015.December.21.15.

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents.
Kursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S.
Diabetes. 2016 Mar;65(3):610-8. doi: 10.2337/db15-1478. Epub 2015 Dec 30.

AAL exacerbates pro-inflammatory response in macrophages by regulating Mincle/Syk/Card9 signaling along with the Nlrp3 inflammasome assembly.
Zhang Z, He L, Hu S, Wang Y, Lai Q, Yang P, Yu Q, Zhang S, Xiong F, Simsekyilmaz S, Ning Q, Li J, Zhang D, Zhang H, Xiang X, Zhou Z, Sun H, Wang CY.
Am J Transl Res. 2015 Oct 15;7(10):1812-25. eCollection 2015.

Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes.
Kim Y, Wang W, Okla M, Kang I, Moreau R, Chung S.
J Lipid Res. 2016 Jan;57(1):66-76. doi: 10.1194/jlr.M062828. Epub 2015 Dec 1.

Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages.
Kim SJ, Cha JY, Kang HS, Lee JH, Lee JY, Park JH, Bae JH, Song DK, Im SS.
BMB Rep. 2016 May;49(5):276-81.

Anti-inflammatory properties of Morus bombycis Koidzumi via inhibiting IFN-β signaling and NLRP3inflammasome activation.
Oh NH, Han JW, Shim DW, Sim EJ, Koppula S, Kwak SB, Kim MK, Kim YK, Jiang J, Park PJ, Kang TB, Lee KH.
J Ethnopharmacol. 2015 Dec 24;176:424-8. doi: 10.1016/j.jep.2015.11.022. Epub 2015 Nov 10.

Innate immunity in diabetes and diabetic nephropathy.
Wada J, Makino H.
Nat Rev Nephrol. 2016 Jan;12(1):13-26. doi: 10.1038/nrneph.2015.175. Epub 2015 Nov 16. Review.

[Research Advances in NLRP3 Inflammasome-related Regulatory Mechanisms].
Wang CY, Guo XC, Zhang JP.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2015 Oct;37(5):618-22. doi: 10.3881/j.issn.1000-503X.2015.05.022. Chinese. 

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation.
Schmid-Burgk JL, Chauhan D, Schmidt T, Ebert TS, Reinhardt J, Endl E, Hornung V.
J Biol Chem. 2016 Jan 1;291(1):103-9. doi: 10.1074/jbc.C115.700492. Epub 2015 Nov 9.

NLR family pyrin domain containing 3 (NLRP3) inflammasome gene polymorphism rs7512998 (C>T) predicts aging-related increase of blood pressure, the TAMRISK study.
Kunnas T, Määttä K, Nikkari ST.
Immun Ageing. 2015 Oct 31;12:19. doi: 10.1186/s12979-015-0047-7. eCollection 2015.

Is immunity a mechanism contributing to statin-induced diabetes?
Henriksbo BD, Schertzer JD.
Adipocyte. 2015 Apr 20;4(4):232-8. doi: 10.1080/21623945.2015.1024394. eCollection 2015 Oct-Dec. Review.

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats.
Mocanu AO, Mulya A, Huang H, Dan O, Shimizu H, Batayyah E, Brethauer SA, Dinischiotu A, Kirwan JP.
PLoS One. 2015 Oct 5;10(10):e0139764. doi: 10.1371/journal.pone.0139764. eCollection 2015.

Miro1-mediated mitochondrial dysfunction under high nutrient stress is linked to NOD-like receptor 3 (NLRP3)-dependent inflammatory responses in rat pancreatic beta cells.
Gao J, Sang M, Zhang X, Zheng T, Pan J, Dai M, Zhou L, Yang S.
Free Radic Biol Med. 2015 Dec;89:322-32. doi: 10.1016/j.freeradbiomed.2015.09.002. Epub 2015 Sep 30.

Inhibiting the Inflammasome: A Chemical Perspective.
Baldwin AG, Brough D, Freeman S.
J Med Chem. 2016 Mar 10;59(5):1691-710. doi: 10.1021/acs.jmedchem.5b01091. Epub 2015 Oct 12. Review.

TLR4 mutant mice are protected from renal fibrosis and chronic kidney disease progression.
Souza AC, Tsuji T, Baranova IN, Bocharov AV, Wilkins KJ, Street JM, Alvarez-Prats A, Hu X, Eggerman T, Yuen PS, Star RA.
Physiol Rep. 2015 Sep;3(9). pii: e12558. doi: 10.14814/phy2.12558.

The NLRP3 inflammasome is dispensable for ER stress-induced pancreatic β-cell damage in Akita mice.
Wang J, Song MY, Lee JY, Kwon KS, Park BH.
Biochem Biophys Res Commun. 2015 Oct 23;466(3):300-5. doi: 10.1016/j.bbrc.2015.09.009. Epub 2015 Sep 7.

Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes.
Kien CL, Bunn JY, Fukagawa NK, Anathy V, Matthews DE, Crain KI, Ebenstein DB, Tarleton EK, Pratley RE, Poynter ME.
J Nutr Biochem. 2015 Dec;26(12):1599-606. doi: 10.1016/j.jnutbio.2015.07.014. Epub 2015 Aug 1.

NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets.
Hu C, Ding H, Li Y, Pearson JA, Zhang X, Flavell RA, Wong FS, Wen L.
Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11318-23. doi: 10.1073/pnas.1513509112. Epub 2015 Aug 24.

Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis.
Bando S, Fukuda D, Soeki T, Nishimoto S, Uematsu E, Matsuura T, Ise T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
Atherosclerosis. 2015 Oct;242(2):407-14. doi: 10.1016/j.atherosclerosis.2015.07.043. Epub 2015 Jul 29.

NLRP3 Inflammasome Polymorphism and Macrovascular Complications in Type 2 Diabetes Patients.
Klen J, Goričar K, Janež A, Dolžan V.
Diabetes Res. 2015;2015:616747. doi: 10.1155/2015/616747. Epub 2015 Jul 27.

Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway.
Wang X, He G, Peng Y, Zhong W, Wang Y, Zhang B.
Sci Rep. 2015 Aug 3;5:12676. doi: 10.1038/srep12676.

Anti-inflammatory effects of grape seed procyanidin B2 on a diabetic pancreas.
Yin W, Li B, Li X, Yu F, Cai Q, Zhang Z, Cheng M, Gao H.
Food Funct. 2015 Sep;6(9):3065-71. doi: 10.1039/c5fo00496a.

Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3inflammasome.
Sun C, Fan S, Wang X, Lu J, Zhang Z, Wu D, Shan Q, Zheng Y.
J Nutr Biochem. 2015 Oct;26(10):1029-40. doi: 10.1016/j.jnutbio.2015.04.012. Epub 2015 May 15.

Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1β via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a possible implication for therapeutic decision in these patients.
Ruscitti P, Cipriani P, Di Benedetto P, Liakouli V, Berardicurti O, Carubbi F, Ciccia F, Alvaro S, Triolo G, Giacomelli R.
Clin Exp Immunol. 2015 Oct;182(1):35-44. doi: 10.1111/cei.12667. Epub 2015 Jul 19.

The mitochondrial Na(+)/Ca(2+) exchanger may reduce high glucose-induced oxidative stress and nucleotide-binding oligomerization domain receptor 3 inflammasome activation in endothelial cells.
Zu Y, Wan LJ, Cui SY, Gong YP, Li CL.
J Geriatr Cardiol. 2015 May;12(3):270-8. doi: 10.11909/j.issn.1671-5411.2015.03.003.

The permissive role of glucocorticoids in neuroinflammatory priming: mechanisms and insights.
Frank MG, Watkins LR, Maier SF.
Curr Opin Endocrinol Diabetes Obes. 2015 Aug;22(4):300-5. doi: 10.1097/MED.0000000000000168. Review.

Bisphosphonate Induces Osteonecrosis of the Jaw in Diabetic Mice via NLRP3/Caspase-1-Dependent IL-1β Mechanism.
Zhang Q, Yu W, Lee S, Xu Q, Naji A, Le AD.
J Bone Miner Res. 2015 Dec;30(12):2300-12. doi: 10.1002/jbmr.2577. Epub 2015 Jul 14.

Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases.
Garcia-Martinez I, Shaker ME, Mehal WZ.
Antioxid Redox Signal. 2015 Dec 10;23(17):1305-15. doi: 10.1089/ars.2015.6383. Epub 2015 Jul 27. Review.

NALP3 inflammasome activation in protein misfolding diseases.
Shi F, Kouadir M, Yang Y.
Life Sci. 2015 Aug 15;135:9-14. doi: 10.1016/j.lfs.2015.05.011. Epub 2015 May 31. Review 

Galectin-3 Ablation Enhances Liver Steatosis, but Attenuates Inflammation and IL-33-Dependent Fibrosis in Obesogenic Mouse Model of Nonalcoholic Steatohepatitis.
Jeftic I, Jovicic N, Pantic J, Arsenijevic N, Lukic ML, Pejnovic N.
Mol Med. 2015 May 22;21:453-65. doi: 10.2119/molmed.2014.00178.

Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond.
Agyemang AF, Harrison SR, Siegel RM, McDermott MF.
Semin Immunopathol. 2015 Jul;37(4):335-47. doi: 10.1007/s00281-015-0496-2. Epub 2015 May 21. Review.

Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes.
Lee HJ, Hong YS, Jun W, Yang SJ.
J Med Food. 2015 Nov;18(11):1207-13. doi: 10.1089/jmf.2015.3439. Epub 2015 May 14.

[Inflammasome: activation mechanisms].
Suárez R, Buelvas N.
Invest Clin. 2015 Mar;56(1):74-99. Review. Spanish. 

Drivers of age-related inflammation and strategies for healthspan extension.
Goldberg EL, Dixit VD.
Immunol Rev. 2015 May;265(1):63-74. doi: 10.1111/imr.12295. Review.

[NLRP3 inflammasome and diabetes].
Liu Q, Li J.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Dec;31(6):1414-8. Review. Chinese. 

Oral Infections, Metabolic Inflammation, Genetics, and Cardiometabolic Diseases.
Janket SJ, Javaheri H, Ackerson LK, Ayilavarapu S, Meurman JH.
J Dent Res. 2015 Sep;94(9 Suppl):119S-27S. doi: 10.1177/0022034515580795. Epub 2015 Apr 3. Review.

NADPH oxidase-induced NALP3 inflammasome activation is driven by thioredoxin-interacting protein which contributes to podocyte injury in hyperglycemia.
Gao P, He FF, Tang H, Lei CT, Chen S, Meng XF, Su H, Zhang C.
Diabetes Res. 2015;2015:504761. doi: 10.1155/2015/504761. Epub 2015 Mar 5. Erratum in: Diabetes Res. 2016;2016:1213892

FGF-21 alleviates diabetes-associated vascular complications: Inhibiting NF-κB/NLRP3inflammasome-mediated inflammation?
Liu MH.
Int J Cardiol. 2015 Apr 15;185:320-1. doi: 10.1016/j.ijcard.2015.03.165. Epub 2015 Mar 17. No abstract available. 

Exercise and inflammation-related epigenetic modifications: focus on DNA methylation.
Horsburgh S, Robson-Ansley P, Adams R, Smith C.
Exerc Immunol Rev. 2015;21:26-41. Review.

Metabolic signals and innate immune activation in obesity and exercise.
Ringseis R, Eder K, Mooren FC, Krüger K.
Exerc Immunol Rev. 2015;21:58-68. Review.

Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease.
Paramel GV, Sirsjö A, Fransén K.
Mediators Inflamm. 2015;2015:846782. doi: 10.1155/2015/846782. Epub 2015 Feb 18. Review.

Taming the inflammasome.
Levy M, Thaiss CA, Elinav E.
Nat Med. 2015 Mar;21(3):213-5. doi: 10.1038/nm.3808. No abstract available. 

Helicobacter pylori-specific protection against inflammatory bowel disease requires the NLRP3inflammasome and IL-18.
Engler DB, Leonardi I, Hartung ML, Kyburz A, Spath S, Becher B, Rogler G, Müller A.
Inflamm Bowel Dis. 2015 Apr;21(4):854-61. doi: 10.1097/MIB.0000000000000318 

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D’Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD.
Nat Med. 2015 Mar;21(3):263-9. doi: 10.1038/nm.3804. Epub 2015 Feb 16.

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O’Neill LA.
Nat Med. 2015 Mar;21(3):248-55. doi: 10.1038/nm.3806. Epub 2015 Feb 16.

Thioredoxin-interacting protein: a potential therapeutic target for treatment of progressive fibrosis in diabetic nephropathy.
Tan CY, Weier Q, Zhang Y, Cox AJ, Kelly DJ, Langham RG.
Nephron. 2015;129(2):109-27. doi: 10.1159/000368238. Epub 2015 Jan 31.

Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy.
Kim SM, Lee SH, Kim YG, Kim SY, Seo JW, Choi YW, Kim DJ, Jeong KH, Lee TW, Ihm CG, Won KY, Moon JY.
Am J Physiol Renal Physiol. 2015 May 1;308(9):F993-F1003. doi: 10.1152/ajprenal.00637.2014. Epub 2015 Jan 28.

Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity.
Finucane OM, Lyons CL, Murphy AM, Reynolds CM, Klinger R, Healy NP, Cooke AA, Coll RC, McAllan L, Nilaweera KN, O’Reilly ME, Tierney AC, Morine MJ, Alcala-Diaz JF, Lopez-Miranda J, O’Connor DP, O’Neill LA, McGillicuddy FC, Roche HM.
Diabetes. 2015 Jun;64(6):2116-28. doi: 10.2337/db14-1098. Epub 2015 Jan 27.

NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.
Abderrazak A, Syrovets T, Couchie D, El Hadri K, Friguet B, Simmet T, Rouis M.
Redox Biol. 2015;4:296-307. doi: 10.1016/j.redox.2015.01.008. Epub 2015 Jan 14. Review.

Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: One stone hits two birds.
Xu C, Wan X, Xu L, Weng H, Yan M, Miao M, Sun Y, Xu G, Dooley S, Li Y, Yu C.
J Hepatol. 2015 Jun;62(6):1412-9. doi: 10.1016/j.jhep.2015.01.019. Epub 2015 Jan 23.

Revisiting inflammation in diabetic nephropathy: the role of the Nlrp3 inflammasome in glomerular resident cells.
Sakai N, Wada T.
Kidney Int. 2015 Jan;87(1):12-4. doi: 10.1038/ki.2014.322.

Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation.
Patel MN, Bernard WG, Milev NB, Cawthorn WP, Figg N, Hart D, Prieur X, Virtue S, Hegyi K, Bonnafous S, Bailly-Maitre B, Chu Y, Griffin JL, Mallat Z, Considine RV, Tran A, Gual P, Takeuchi O, Akira S, Vidal-Puig A, Bennett MR, Sethi JK.
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):506-11. doi: 10.1073/pnas.1414536112. Epub 2014 Dec 24.

Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity.
Yang S, Xia C, Li S, Du L, Zhang L, Zhou R.
Redox Biol. 2014;3:63-71. doi: 10.1016/j.redox.2014.04.001. Epub 2014 Apr 12.

Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells.
Yang H, Xiao L, Yuan Y, Luo X, Jiang M, Ni J, Wang N.
Biochem Pharmacol. 2014 Dec 15;92(4):599-606. doi: 10.1016/j.bcp.2014.10.001. Epub 2014 Oct 23.

Toll-like receptor 2 and NLRP3 cooperate to recognize a functional bacterial amyloid, curli.
Rapsinski GJ, Wynosky-Dolfi MA, Oppong GO, Tursi SA, Wilson RP, Brodsky IE, Tükel Ç.
Infect Immun. 2015 Feb;83(2):693-701. doi: 10.1128/IAI.02370-14. Epub 2014 Nov 24.

Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets.
Wali JA, Gurzov EN, Fynch S, Elkerbout L, Kay TW, Masters SL, Thomas HE.
PLoS One. 2014 Nov 18;9(11):e113128. doi: 10.1371/journal.pone.0113128. eCollection 2014.

Glucose and metformin modulate human first trimester trophoblast function: a model and potential therapy for diabetes-associated uteroplacental insufficiency.
Han CS, Herrin MA, Pitruzzello MC, Mulla MJ, Werner EF, Pettker CM, Flannery CA, Abrahams VM.
Am J Reprod Immunol. 2015 Apr;73(4):362-71. doi: 10.1111/aji.12339. Epub 2014 Nov 14.

CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells.
Paget C, Chow MT, Gherardin NA, Beavis PA, Uldrich AP, Duret H, Hassane M, Souza-Fonseca-Guimaraes F, Mogilenko DA, Staumont-Sallé D, Escalante NK, Hill GR, Neeson P, Ritchie DS, Dombrowicz D, Mallevaey T, Trottein F, Belz GT, Godfrey DI, Smyth MJ.
Immunol Cell Biol. 2015 Feb;93(2):198-212. doi: 10.1038/icb.2014.94. Epub 2014 Nov 11.

Procyanidin B2 inhibits inflammasome-mediated IL-1β production in lipopolysaccharide-stimulated macrophages.
Martinez-Micaelo N, González-Abuín N, Pinent M, Ardévol A, Blay M.
Mol Nutr Food Res. 2015 Feb;59(2):262-9. doi: 10.1002/mnfr.201400370. Epub 2014 Dec 5.

Statin-induced insulin resistance through inflammasome activation: sailing between Scylla and Charybdis.
Mitchell P, Marette A.
Diabetes. 2014 Nov;63(11):3569-71. doi: 10.2337/db14-1059. No abstract available. 

Hyperglucose contributes to periodontitis: involvement of the NLRP3 pathway by engaging the innate immunity of oral gingival epithelium.
Huang X, Yang X, Ni J, Xie B, Liu Y, Xuan D, Zhang J.
J Periodontol. 2015 Feb;86(2):327-35. doi: 10.1902/jop.2014.140403. Epub 2014 Oct 17.

Natural compounds and aging: between autophagy and inflammasome.
Chuang SY, Lin CH, Fang JY.
Biomed Res Int. 2014;2014:297293. doi: 10.1155/2014/297293. Epub 2014 Sep 14. Review.

Losartan inhibits LPS + ATP-induced IL-1beta secretion from mouse primary macrophages by suppressing NALP3 inflammasome.
Wang F, Huang L, Peng ZZ, Tang YT, Lu MM, Peng Y, Mel WJ, Wu L, Mo ZH, Meng J, Tao LJ.
Pharmazie. 2014 Sep;69(9):680-4 

Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation.
Honda H, Nagai Y, Matsunaga T, Okamoto N, Watanabe Y, Tsuneyama K, Hayashi H, Fujii I, Ikutani M, Hirai Y, Muraguchi A, Takatsu K.
J Leukoc Biol. 2014 Dec;96(6):1087-100. doi: 10.1189/jlb.3A0114-005RR. Epub 2014 Sep 10.

Flavonoid apigenin inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in macrophages.
Zhang X, Wang G, Gurley EC, Zhou H.
PLoS One. 2014 Sep 5;9(9):e107072. doi: 10.1371/journal.pone.0107072. eCollection 2014.

Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes.
Legrand-Poels S, Esser N, L’homme L, Scheen A, Paquot N, Piette J.
Biochem Pharmacol. 2014 Nov 1;92(1):131-41. doi: 10.1016/j.bcp.2014.08.013. Epub 2014 Aug 28. Review.

NLRP3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat model.
Luo B, Li B, Wang W, Liu X, Xia Y, Zhang C, Zhang M, Zhang Y, An F.
PLoS One. 2014 Aug 19;9(8):e104771. doi: 10.1371/journal.pone.0104771. eCollection 2014.

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy.
Shahzad K, Bock F, Dong W, Wang H, Kopf S, Kohli S, Al-Dabet MM, Ranjan S, Wolter J, Wacker C, Biemann R, Stoyanov S, Reymann K, Söderkvist P, Groß O, Schwenger V, Pahernik S, Nawroth PP, Gröne HJ, Madhusudhan T, Isermann B.
Kidney Int. 2015 Jan;87(1):74-84. doi: 10.1038/ki.2014.271. Epub 2014 Jul 30.

[Development of research on relationship between NLRP3 inflammasome and type 2 diabetes].
Wang DK, Chen G, Lu FE.
Sheng Li Ke Xue Jin Zhan. 2014 Apr;45(2):111-4. Chinese. No abstract available. 

Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation.
Yin Z, Deng T, Peterson LE, Yu R, Lin J, Hamilton DJ, Reardon PR, Sherman V, Winnier GE, Zhan M, Lyon CJ, Wong ST, Hsueh WA.
Mol Cell Endocrinol. 2014 Aug 25;394(1-2):80-7. doi: 10.1016/j.mce.2014.06.018. Epub 2014 Jul 7.

Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice.
Meier DT, Morcos M, Samarasekera T, Zraika S, Hull RL, Kahn SE.
Diabetologia. 2014 Sep;57(9):1884-8. doi: 10.1007/s00125-014-3304-y. Epub 2014 Jun 26.

Interactions between differential fatty acids and inflammatory stressors-impact on metabolic health.
Murphy AM, Lyons CL, Finucane OM, Roche HM.
Prostaglandins Leukot Essent Fatty Acids. 2015 Jan;92:49-55. doi: 10.1016/j.plefa.2014.05.003. Epub 2014 Jun 3. Review.

Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance.
Henriksbo BD, Lau TC, Cavallari JF, Denou E, Chi W, Lally JS, Crane JD, Duggan BM, Foley KP, Fullerton MD, Tarnopolsky MA, Steinberg GR, Schertzer JD.
Diabetes. 2014 Nov;63(11):3742-7. doi: 10.2337/db13-1398. Epub 2014 Jun 10.

NLRP3, a potential therapeutic target for type 2 diabetes?
Liu SS, Ding Y, Lou JQ.
Cardiovasc Drugs Ther. 2014 Aug;28(4):391-2. doi: 10.1007/s10557-014-6531-z. No abstract available. 

Inflammasomes: molecular regulation and implications for metabolic and cognitive diseases.
Choi AJ, Ryter SW.
Mol Cells. 2014 Jun;37(6):441-8. doi: 10.14348/molcells.2014.0104. Epub 2014 May 19. Review.

Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity.
Nagareddy PR, Kraakman M, Masters SL, Stirzaker RA, Gorman DJ, Grant RW, Dragoljevic D, Hong ES, Abdel-Latif A, Smyth SS, Choi SH, Korner J, Bornfeldt KE, Fisher EA, Dixit VD, Tall AR, Goldberg IJ, Murphy AJ.
Cell Metab. 2014 May 6;19(5):821-35. doi: 10.1016/j.cmet.2014.03.029.

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes.
Esser N, Legrand-Poels S, Piette J, Scheen AJ, Paquot N.
Diabetes Res Clin Pract. 2014 Aug;105(2):141-50. doi: 10.1016/j.diabres.2014.04.006. Epub 2014 Apr 13. Review.

Macrophage CGI-58 deficiency activates ROS-inflammasome pathway to promote insulin resistance in mice.
Miao H, Ou J, Ma Y, Guo F, Yang Z, Wiggins M, Liu C, Song W, Han X, Wang M, Cao Q, Chung BH, Yang D, Liang H, Xue B, Shi H, Gan L, Yu L.
Cell Rep. 2014 Apr 10;7(1):223-35. doi: 10.1016/j.celrep.2014.02.047. Epub 2014 Apr 3.

AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease.
Steinberg GR, Schertzer JD.
Immunol Cell Biol. 2014 Apr;92(4):340-5. doi: 10.1038/icb.2014.11. Epub 2014 Mar 18. Review.

Physiologic versus diabetogenic effects of interleukin-1: a question of weight.
Besedovsky HO, Del Rey A.
Curr Pharm Des. 2014;20(29):4733-40. Review.

Leukocyte infiltration and activation of the NLRP3 inflammasome in white adipose tissue following thermal injury.
Stanojcic M, Chen P, Harrison RA, Wang V, Antonyshyn J, Zúñiga-Pflücker JC, Jeschke MG.
Crit Care Med. 2014 Jun;42(6):1357-64. doi: 10.1097/CCM.0000000000000209.

Lysosomes integrate metabolic-inflammatory cross-talk in primary macrophage inflammasome activation.
Weber K, Schilling JD.
J Biol Chem. 2014 Mar 28;289(13):9158-71. doi: 10.1074/jbc.M113.531202. Epub 2014 Feb 15.

T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes.
Dalmas E, Venteclef N, Caer C, Poitou C, Cremer I, Aron-Wisnewsky J, Lacroix-Desmazes S, Bayry J, Kaveri SV, Clément K, André S, Guerre-Millo M.
Diabetes. 2014 Jun;63(6):1966-77. doi: 10.2337/db13-1511. Epub 2014 Feb 11.

Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes.
Westwell-Roper C, Nackiewicz D, Dan M, Ehses JA.
Immunol Cell Biol. 2014 Apr;92(4):314-23. doi: 10.1038/icb.2014.4. Epub 2014 Feb 4. Review.

IL-1 blockade in autoinflammatory syndromes.
Jesus AA, Goldbach-Mansky R.
Annu Rev Med. 2014;65:223-44. doi: 10.1146/annurev-med-061512-150641. Review.

[NLRP3 inflammasome and visceral adipose tissue].
Esser N, Legrand-Poels S, Piette J, Paquot N, Scheen AJ.
Rev Med Liege. 2014;69 Spec No:57-61. French. 

Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice.
Bitto A, Altavilla D, Pizzino G, Irrera N, Pallio G, Colonna MR, Squadrito F.
Br J Pharmacol. 2014 May;171(9):2300-7. doi: 10.1111/bph.12557.

Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis.
Yang SM, Ka SM, Wu HL, Yeh YC, Kuo CH, Hua KF, Shi GY, Hung YJ, Hsiao FC, Yang SS, Shieh YS, Lin SH, Wei CW, Lee JS, Yang CY, Chen A.
Diabetologia. 2014 Feb;57(2):424-34. doi: 10.1007/s00125-013-3115-6. Epub 2013 Nov 30.

Treating inflammation by blocking interleukin-1 in humans.
Dinarello CA, van der Meer JW.
Semin Immunol. 2013 Dec 15;25(6):469-84. doi: 10.1016/j.smim.2013.10.008. Epub 2013 Nov 23. Review.

Leptin enhances the secretion of interleukin (IL)-18, but not IL-1β, from human monocytes via activation of caspase-1.
Jitprasertwong P, Jaedicke KM, Nile CJ, Preshaw PM, Taylor JJ.
Cytokine. 2014 Feb;65(2):222-30. doi: 10.1016/j.cyto.2013.10.008. Epub 2013 Nov 23 

Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model.
Luo B, Li B, Wang W, Liu X, Liu X, Xia Y, Zhang C, Zhang Y, Zhang M, An F.
Cardiovasc Drugs Ther. 2014 Feb;28(1):33-43. doi: 10.1007/s10557-013-6498-1.

The NLRP3 inflammasome and diabetic cardiomyopathy : editorial to: “Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model” by Beibei Luo et al.
Singh LP.
Cardiovasc Drugs Ther. 2014 Feb;28(1):5-6. doi: 10.1007/s10557-013-6501-x. No abstract available. 

Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice.
Wang L, Zhai YQ, Xu LL, Qiao C, Sun XL, Ding JH, Lu M, Hu G.
Exp Neurol. 2014 Jan;251:22-9. doi: 10.1016/j.expneurol.2013.11.001. Epub 2013 Nov 9.

Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways.
Kim S, Joe Y, Jeong SO, Zheng M, Back SH, Park SW, Ryter SW, Chung HT.
Innate Immun. 2014 Nov;20(8):799-815. doi: 10.1177/1753425913508593. Epub 2013 Nov 11

Sustained inflammasome activity in macrophages impairs wound healing in type 2 diabetic humans and mice.
Mirza RE, Fang MM, Weinheimer-Haus EM, Ennis WJ, Koh TJ.
Diabetes. 2014 Mar;63(3):1103-14. doi: 10.2337/db13-0927. Epub 2013 Nov 5.

CD36: linking lipids to the NLRP3 inflammasome, atherogenesis and atherothrombosis.
Oury C.
Cell Mol Immunol. 2014 Jan;11(1):8-10. doi: 10.1038/cmi.2013.48. Epub 2013 Oct 7. No abstract available. 

Galectin-3 is a regulator of metaflammation in adipose tissue and pancreatic islets.
Pejnovic NN, Pantic JM, Jovanovic IP, Radosavljevic GD, Djukic ALj, Arsenijevic NN, Lukic ML.
Adipocyte. 2013 Oct 1;2(4):266-71. doi: 10.4161/adip.24881. Epub 2013 May 7.

NLRP3 and IL-1β in macrophages as critical regulators of metabolic diseases.
McGettrick AF, O’Neill LA.
Diabetes Obes Metab. 2013 Sep;15 Suppl 3:19-25. doi: 10.1111/dom.12169. Review.

Macrophages control innate inflammation.
Akira S, Misawa T, Satoh T, Saitoh T.
Diabetes Obes Metab. 2013 Sep;15 Suppl 3:10-8. doi: 10.1111/dom.12151. Review.

Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages.
L’homme L, Esser N, Riva L, Scheen A, Paquot N, Piette J, Legrand-Poels S.
J Lipid Res. 2013 Nov;54(11):2998-3008. doi: 10.1194/jlr.M037861. Epub 2013 Sep 3.

Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?
Lawlor KE, Vince JE.
Biochim Biophys Acta. 2014 Apr;1840(4):1433-40. doi: 10.1016/j.bbagen.2013.08.014. Epub 2013 Aug 27. Review.

Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line.
Li S, Du L, Zhang L, Hu Y, Xia W, Wu J, Zhu J, Chen L, Zhu F, Li C, Yang S.
J Biol Chem. 2013 Oct 18;288(42):30094-104. doi: 10.1074/jbc.M113.494286. Epub 2013 Aug 28.

Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells.
Fang L, Xie D, Wu X, Cao H, Su W, Yang J.
PLoS One. 2013 Aug 20;8(8):e72344. doi: 10.1371/journal.pone.0072344. eCollection 2013.

Variants of NLRP3 gene are associated with insulin resistance in Chinese Han population with type-2 diabetes.
Zheng Y, Zhang D, Zhang L, Fu M, Zeng Y, Russell R.
Gene. 2013 Nov 1;530(1):151-4. doi: 10.1016/j.gene.2013.07.082. Epub 2013 Aug 22.

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.
Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, Tam J, Han T, Mukhopadhyay B, Skarulis MC, Ju C, Aouadi M, Czech MP, Kunos G.
Nat Med. 2013 Sep;19(9):1132-40. doi: 10.1038/nm.3265. Epub 2013 Aug 18.

Closing the loop on inflammation and atherothrombosis: why perform the CIRT and CANTOS trials?
Ridker PM.
Trans Am Clin Climatol Assoc. 2013;124:174-90.

NLRP3 inflammasome activation: CD36 serves double duty.
Kagan JC, Horng T.
Nat Immunol. 2013 Aug;14(8):772-4. doi: 10.1038/ni.2668. No abstract available. 

The NLRP3 Inflammasome as a novel player of the intercellular crosstalk in metabolic disorders.
Benetti E, Chiazza F, Patel NS, Collino M.
Mediators Inflamm. 2013;2013:678627. doi: 10.1155/2013/678627. Epub 2013 Jun 13. Review.

The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation.
Solini A, Menini S, Rossi C, Ricci C, Santini E, Blasetti Fantauzzi C, Iacobini C, Pugliese G.
J Pathol. 2013 Nov;231(3):342-53. doi: 10.1002/path.4237. Epub 2013 Sep 3.

Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis.
Giordano A, Murano I, Mondini E, Perugini J, Smorlesi A, Severi I, Barazzoni R, Scherer PE, Cinti S.
J Lipid Res. 2013 Sep;54(9):2423-36. doi: 10.1194/jlr.M038638. Epub 2013 Jul 8.

Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs.
Li Y, Xu S, Jiang B, Cohen RA, Zang M.
PLoS One. 2013 Jun 25;8(6):e67532. doi: 10.1371/journal.pone.0067532. Print 2013.

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA, Moore KJ.
Nat Immunol. 2013 Aug;14(8):812-20. doi: 10.1038/ni.2639. Epub 2013 Jun 30.

Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3inflammasome activation.
Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z, Tschopp J, Zhou R.
Immunity. 2013 Jun 27;38(6):1154-63. doi: 10.1016/j.immuni.2013.05.015.

(De-) oiling inflammasomes.
Marty-Roix R, Lien E.
Immunity. 2013 Jun 27;38(6):1088-90. doi: 10.1016/j.immuni.2013.06.006.

How metabolism generates signals during innate immunity and inflammation.
McGettrick AF, O’Neill LA.
J Biol Chem. 2013 Aug 9;288(32):22893-8. doi: 10.1074/jbc.R113.486464. Epub 2013 Jun 24. Review.

miR-223: infection, inflammation and cancer.
Haneklaus M, Gerlic M, O’Neill LA, Masters SL.
J Intern Med. 2013 Sep;274(3):215-26. doi: 10.1111/joim.12099. Epub 2013 Jun 25. Review.

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance.
Lee BC, Lee J.
Biochim Biophys Acta. 2014 Mar;1842(3):446-62. doi: 10.1016/j.bbadis.2013.05.017. Epub 2013 May 22. Review.

Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats.
Wang W, Wang C, Ding XQ, Pan Y, Gu TT, Wang MX, Liu YL, Wang FM, Wang SJ, Kong LD.
Br J Pharmacol. 2013 Jul;169(6):1352-71. doi: 10.1111/bph.12226.

Mechanisms of disease: inflammasome activation and the development of type 2 diabetes.
Grant RW, Dixit VD.
Front Immunol. 2013 Mar 8;4:50. doi: 10.3389/fimmu.2013.00050. eCollection 2013.

Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis.
Shimabukuro M, Hirata Y, Tabata M, Dagvasumberel M, Sato H, Kurobe H, Fukuda D, Soeki T, Kitagawa T, Takanashi S, Sata M.
Arterioscler Thromb Vasc Biol. 2013 May;33(5):1077-84. doi: 10.1161/ATVBAHA.112.300829. Epub 2013 Mar 7.

NLRP3 inflammasomes show high expression in aorta of patients with atherosclerosis.
Zheng F, Xing S, Gong Z, Xing Q.
Heart Lung Circ. 2013 Sep;22(9):746-50. doi: 10.1016/j.hlc.2013.01.012. Epub 2013 Feb 23.

Nalp3 inflammasome is activated and required for vascular smooth muscle cell calcification.
Wen C, Yang X, Yan Z, Zhao M, Yue X, Cheng X, Zheng Z, Guan K, Dou J, Xu T, Zhang Y, Song T, Wei C, Zhong H.
Int J Cardiol. 2013 Oct 3;168(3):2242-7. doi: 10.1016/j.ijcard.2013.01.211. Epub 2013 Feb 27.

ATP-P2X4 signaling mediates NLRP3 inflammasome activation: a novel pathway of diabetic nephropathy.
Chen K, Zhang J, Zhang W, Zhang J, Yang J, Li K, He Y.
Int J Biochem Cell Biol. 2013 May;45(5):932-43. doi: 10.1016/j.biocel.2013.02.009. Epub 2013 Feb 19.

Galectin-3 deficiency accelerates high-fat diet-induced obesity and amplifies inflammation in adipose tissue and pancreatic islets.
Pejnovic NN, Pantic JM, Jovanovic IP, Radosavljevic GD, Milovanovic MZ, Nikolic IG, Zdravkovic NS, Djukic AL, Arsenijevic NN, Lukic ML.
Diabetes. 2013 Jun;62(6):1932-44. doi: 10.2337/db12-0222. Epub 2013 Jan 24.

Autophagy regulates inflammation following oxidative injury in diabetes.
Wang Y, Li YB, Yin JJ, Wang Y, Zhu LB, Xie GY, Pan SH.
Autophagy. 2013 Mar;9(3):272-7. doi: 10.4161/auto.23628. Epub 2013 Jan 23. Review.

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments.
Haneklaus M, O’Neill LA, Coll RC.
Curr Opin Immunol. 2013 Feb;25(1):40-5. doi: 10.1016/j.coi.2012.12.004. Epub 2013 Jan 7. Review.

Specific inflammasomes in complex diseases.
Masters SL.
Clin Immunol. 2013 Jun;147(3):223-8. doi: 10.1016/j.clim.2012.12.006. Epub 2012 Dec 21. Review.

Inflammasomes: sensors of metabolic stresses for vascular inflammation.
Yin Y, Pastrana JL, Li X, Huang X, Mallilankaraman K, Choi ET, Madesh M, Wang H, Yang XF.
Front Biosci (Landmark Ed). 2013 Jan 1;18:638-49. Review.

Linking metabolic abnormalities to apoptotic pathways in Beta cells in type 2 diabetes.
Wali JA, Masters SL, Thomas HE.
Cells. 2013 Apr 26;2(2):266-83. doi: 10.3390/cells2020266.

Nlrp3 inflammasome activation in type 2 diabetes: is it clinically relevant?
Dixit VD.
Diabetes. 2013 Jan;62(1):22-4. doi: 10.2337/db12-1115. No abstract available. 

Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation.
Collino M, Benetti E, Rogazzo M, Mastrocola R, Yaqoob MM, Aragno M, Thiemermann C, Fantozzi R.
Biochem Pharmacol. 2013 Jan 15;85(2):257-64. doi: 10.1016/j.bcp.2012.10.014. Epub 2012 Oct 24.

Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes.
Lee HM, Kim JJ, Kim HJ, Shong M, Ku BJ, Jo EK.
Diabetes. 2013 Jan;62(1):194-204. doi: 10.2337/db12-0420. Epub 2012 Oct 18.

Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.
Vajjhala PR, Mirams RE, Hill JM.
J Biol Chem. 2012 Dec 7;287(50):41732-43. doi: 10.1074/jbc.M112.381228. Epub 2012 Oct 12.

Autoinflammatory syndromes and cellular responses to stress: pathophysiology, diagnosis and new treatment perspectives.
Savic S, Dickie LJ, Wittmann M, McDermott MF.
Best Pract Res Clin Rheumatol. 2012 Aug;26(4):505-33. doi: 10.1016/j.berh.2012.07.009.

Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation.
Juliana C, Fernandes-Alnemri T, Kang S, Farias A, Qin F, Alnemri ES.
J Biol Chem. 2012 Oct 19;287(43):36617-22. doi: 10.1074/jbc.M112.407130. Epub 2012 Sep 4.

Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family.
Tack CJ, Stienstra R, Joosten LA, Netea MG.
Immunol Rev. 2012 Sep;249(1):239-52. doi: 10.1111/j.1600-065X.2012.01145.x. Review.

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome.
Oslowski CM, Hara T, O’Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Zhu LJ, Hayashi E, Hui ST, Greiner D, Kaufman RJ, Bortell R, Urano F.
Cell Metab. 2012 Aug 8;16(2):265-73. doi: 10.1016/j.cmet.2012.07.005.

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR.
Cell Metab. 2012 Aug 8;16(2):250-64. doi: 10.1016/j.cmet.2012.07.007.

TXNIP switches tracks toward a terminal UPR.
Anthony TG, Wek RC.
Cell Metab. 2012 Aug 8;16(2):135-7. doi: 10.1016/j.cmet.2012.07.012.

Elovl6 promotes nonalcoholic steatohepatitis.
Matsuzaka T, Atsumi A, Matsumori R, Nie T, Shinozaki H, Suzuki-Kemuriyama N, Kuba M, Nakagawa Y, Ishii K, Shimada M, Kobayashi K, Yatoh S, Takahashi A, Takekoshi K, Sone H, Yahagi N, Suzuki H, Murata S, Nakamuta M, Yamada N, Shimano H.
Hepatology. 2012 Dec;56(6):2199-208. doi: 10.1002/hep.25932.

Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3inflammasome activation and lipid accumulation.
Wang C, Pan Y, Zhang QY, Wang FM, Kong LD.
PLoS One. 2012;7(6):e38285. doi: 10.1371/journal.pone.0038285. Epub 2012 Jun 11.

Biochemical regulation of the inflammasome.
Dowling JK, O’Neill LA.
Crit Rev Biochem Mol Biol. 2012 Sep;47(5):424-43. doi: 10.3109/10409238.2012.694844. Epub 2012 Jun 11. Review.

The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory Diseases.
Yang CS, Shin DM, Jo EK.
Int Neurourol J. 2012 Mar;16(1):2-12. doi: 10.5213/inj.2012.16.1.2. Epub 2012 Mar 31.

TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy.
Devi TS, Lee I, Hüttemann M, Kumar A, Nantwi KD, Singh LP.
Exp Diabetes Res. 2012;2012:438238. doi: 10.1155/2012/438238. Epub 2012 Mar 18.

A role for the NLRP3 inflammasome in metabolic diseases–did Warburg miss inflammation?
Wen H, Ting JP, O’Neill LA.
Nat Immunol. 2012 Mar 19;13(4):352-7. doi: 10.1038/ni.2228. Review.

Inflammaging: disturbed interplay between autophagy and inflammasomes.
Salminen A, Kaarniranta K, Kauppinen A.
Aging (Albany NY). 2012 Mar;4(3):166-75.

Toll-like receptors, the NLRP3 inflammasome, and interleukin-1β in the development and progression of type 1 diabetes.
Grishman EK, White PC, Savani RC.
Pediatr Res. 2012 Jun;71(6):626-32. doi: 10.1038/pr.2012.24. Epub 2012 Feb 15. Review.

Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)-1 and an emerging role for cytokines beyond IL-1.
Goldbach-Mansky R.
Clin Exp Immunol. 2012 Mar;167(3):391-404. doi: 10.1111/j.1365-2249.2011.04533.x. Review.

Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes.
Ozkurede VU, Franchi L.
Clin Exp Immunol. 2012 Mar;167(3):382-90. doi: 10.1111/j.1365-2249.2011.04535.x. Review.

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway.
Menu P, Mayor A, Zhou R, Tardivel A, Ichijo H, Mori K, Tschopp J.
Cell Death Dis. 2012 Jan 26;3:e261. doi: 10.1038/cddis.2011.132.

Polimorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus.
Pontillo A, Girardelli M, Kamada AJ, Pancotto JA, Donadi EA, Crovella S, Sandrin-Garcia P.
Autoimmunity. 2012 Jun;45(4):271-8. doi: 10.3109/08916934.2011.637532. Epub 2012 Feb 7.

Familial Mediterranean fever and related periodic fever syndromes/autoinflammatory diseases.
Savic S, Dickie LJ, Battellino M, McDermott MF.
Curr Opin Rheumatol. 2012 Jan;24(1):103-12. doi: 10.1097/BOR.0b013e32834dd2d5. Review.

The inflammasome: in memory of Dr. Jurg Tschopp.
Dagenais M, Skeldon A, Saleh M.
Cell Death Differ. 2012 Jan;19(1):5-12. doi: 10.1038/cdd.2011.159. Epub 2011 Nov 11.

Nucleotide-binding oligomerization domain-like receptors and inflammasomes in the pathogenesis of non-microbial inflammation and diseases.
Mason DR, Beck PL, Muruve DA.
J Innate Immun. 2012;4(1):16-30. doi: 10.1159/000334247. Epub 2011 Nov 4. Review.

[NALP3 inflammasome and non-infectious inflammatory diseases].
Tong YN, He YN.
Sheng Li Ke Xue Jin Zhan. 2011 Aug;42(4):317-20. Review. Chinese. No abstract available. 

Inflammation as a sensor of metabolic stress in obesity and type 2 diabetes.
Donath MY.
Endocrinology. 2011 Nov;152(11):4005-6. doi: 10.1210/en.2011-1691. No abstract available. 

Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage.
Youm YH, Adijiang A, Vandanmagsar B, Burk D, Ravussin A, Dixit VD.
Endocrinology. 2011 Nov;152(11):4039-45. doi: 10.1210/en.2011-1326. Epub 2011 Aug 23.

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly.
Menu P, Vince JE.
Clin Exp Immunol. 2011 Oct;166(1):1-15. doi: 10.1111/j.1365-2249.2011.04440.x. Epub 2011 Jul 15. Review.

NLRP3 inflammasomes link inflammation and metabolic disease.
De Nardo D, Latz E.
Trends Immunol. 2011 Aug;32(8):373-9. doi: 10.1016/ Epub 2011 Jul 4. Review.

Role of innate immunity in diabetes and metabolism: recent progress in the study of inflammasomes.
Lee MS.
Immune Netw. 2011 Apr;11(2):95-9. doi: 10.4110/in.2011.11.2.95. Epub 2011 Apr 30.

Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms.
Roberts RL, Van Rij AM, Phillips LV, Young S, McCormick SP, Merriman TR, Jones GT.
Atherosclerosis. 2011 Sep;218(1):123-6. doi: 10.1016/j.atherosclerosis.2011.04.043. Epub 2011 May 10.

Metabolic syndrome: is Nlrp3 inflammasome a trigger or a target of insulin resistance?
Mori MA, Bezy O, Kahn CR.
Circ Res. 2011 May 13;108(10):1160-2. doi: 10.1161/RES.0b013e318220b57b. Review. No abstract available. Erratum in: Circ Res. 2011 Jun 24;109(1):e13. 

The inflammasomes in kidney disease.
Anders HJ, Muruve DA.
J Am Soc Nephrol. 2011 Jun;22(6):1007-18. doi: 10.1681/ASN.2010080798. Epub 2011 May 12. Review.

The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3.
Tannahill GM, O’Neill LA.
FEBS Lett. 2011 Jun 6;585(11):1568-72. doi: 10.1016/j.febslet.2011.05.008. Epub 2011 May 6. Review.

Insight into the mechanisms regulating immune homeostasis in health and disease.
Sirisinha S.
Asian Pac J Allergy Immunol. 2011 Mar;29(1):1-14. Review.

Current status of understanding the pathogenesis and management of patients with NOMID/CINCA.
Goldbach-Mansky R.
Curr Rheumatol Rep. 2011 Apr;13(2):123-31. doi: 10.1007/s11926-011-0165-y. Review.

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.
Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, Ting JP.
Nat Immunol. 2011 May;12(5):408-15. doi: 10.1038/ni.2022. Epub 2011 Apr 10.

Inflammasome activation: from inflammatory disease to infection.
Dunne A.
Biochem Soc Trans. 2011 Apr;39(2):669-73. doi: 10.1042/BST0390669. Review.

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance.
Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL, Ravussin E, Stephens JM, Dixit VD.
Nat Med. 2011 Feb;17(2):179-88. doi: 10.1038/nm.2279. Epub 2011 Jan 9.

Inflammasome-mediated autoinflammatory disorders.
Wilson SP, Cassel SL.
Postgrad Med. 2010 Sep;122(5):125-33. doi: 10.3810/pgm.2010.09.2209. Review.

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O’Neill LA.
Nat Immunol. 2010 Oct;11(10):897-904. doi: 10.1038/ni.1935. Epub 2010 Sep 12.

Monogenic autoinflammatory diseases: new insights into clinical aspects and pathogenesis.
Henderson C, Goldbach-Mansky R.
Curr Opin Rheumatol. 2010 Sep;22(5):567-78. doi: 10.1097/BOR.0b013e32833ceff4. Review.

Targeting IL-1beta in disease; the expanding role of NLRP3 inflammasome.
Mitroulis I, Skendros P, Ritis K.
Eur J Intern Med. 2010 Jun;21(3):157-63. doi: 10.1016/j.ejim.2010.03.005. Epub 2010 Mar 30. Review.

Inflammasome and IL-1beta-mediated disorders.
Hoffman HM, Wanderer AA.
Curr Allergy Asthma Rep. 2010 Jul;10(4):229-35. doi: 10.1007/s11882-010-0109-z. Review.

Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil.
Pontillo A, Brandao L, Guimaraes R, Segat L, Araujo J, Crovella S.
Autoimmunity. 2010 Dec;43(8):583-9. doi: 10.3109/08916930903540432. Epub 2010 Apr 7.

The NLRP3 inflammasome, a target for therapy in diverse disease states.
Cook GP, Savic S, Wittmann M, McDermott MF.
Eur J Immunol. 2010 Mar;40(3):631-4. doi: 10.1002/eji.200940162. Review.

NLRP3 has a sweet tooth.
Davis BK, Ting JP.
Nat Immunol. 2010 Feb;11(2):105-6. doi: 10.1038/ni0210-105. Review. No abstract available. 

The NLRP3 inflammasome: a sensor for metabolic danger?
Schroder K, Zhou R, Tschopp J.
Science. 2010 Jan 15;327(5963):296-300. doi: 10.1126/science.1184003. Review.

Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J.
Nat Immunol. 2010 Feb;11(2):136-40. doi: 10.1038/ni.1831. Epub 2009 Dec 20.

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.
Lamkanfi M, Mueller JL, Vitari AC, Misaghi S, Fedorova A, Deshayes K, Lee WP, Hoffman HM, Dixit VM.
J Cell Biol. 2009 Oct 5;187(1):61-70. doi: 10.1083/jcb.200903124.

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J.
Nature. 2009 Jul 9;460(7252):269-73. doi: 10.1038/nature08100. Epub 2009 Jun 3.

Allelic variants in genes associated with hereditary periodic fever syndromes as susceptibility factors for reactive systemic AA amyloidosis.
Aganna E, Hawkins PN, Ozen S, Pettersson T, Bybee A, McKee SA, Lachmann HJ, Karenko L, Ranki A, Bakkaloglu A, Besbas N, Topaloglu R, Hoffman HM, Hitman GA, Woo P, McDermott MF.
Genes Immun. 2004 Jun;5(4):289-93.

The autoinflammatory syndromes.
McDermott MF, Aksentijevich I.
Curr Opin Allergy Clin Immunol. 2002 Dec;2(6):511-6. Review.