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Lung Disease and NLRP3


Sphingosine signaling dysfunction in airway cells as a potential contributor to progression from protracted bacterial bronchitis to bronchiectasis in children.
Hodge S, Macowan M, Liu H, Hamon R, Chen AC, Marchant JM, Pizzutto SJ, Upham JW, Chang AB.
Pediatr Pulmonol. 2020 Mar 16. doi: 10.1002/ppul.24728. [Epub ahead of print]

Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1/Nrf2 pathway and inhibiting the NF-κB and NLRP3 pathways in carrageenan-induced pleurisy.
Gao Y, Lv X, Yang H, Peng L, Ci X.
Food Funct. 2020 Mar 1;11(3):2522-2534. doi: 10.1039/c9fo01984g. Epub 2020 Mar 6.

Apelin/APJ system: an emerging therapeutic target for respiratory diseases.
Yan J, Wang A, Cao J, Chen L.
Cell Mol Life Sci. 2020 Mar 3. doi: 10.1007/s00018-020-03461-7. [Epub ahead of print] Review

Hydrogen Sulfide Attenuates Particulate Matter-Induced Emphysema and Airway Inflammation Through Nrf2-Dependent Manner.
Jia G, Yu S, Sun W, Yang J, Wang Y, Qi Y, Chen Y.
Front Pharmacol. 2020 Feb 7;11:29. doi: 10.3389/fphar.2020.00029. eCollection 2020.

A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress.
Zhang YF, Sun CC, Duan JX, Yang HH, Zhang CY, Xiong JB, Zhong WJ, Zu C, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX.
Biomed Pharmacother. 2020 Feb 27;126:109907. doi: 10.1016/j.biopha.2020.109907. [Epub ahead of print

The protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of NLRP3inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells.
Jiao P, Li W, Shen L, Li Y, Yu L, Liu Z.
Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):687-694. doi: 10.1080/21691401.2020.1730391.

Apolipoprotein E negatively regulates murine allergic airway inflammation via suppressing the activation of NLRP3 inflammasome and oxidative stress.
Zhao CC, Xu J, Xie QM, Fan XY, Fei GH, Wu HM.
Int Immunopharmacol. 2020 Feb 12;81:106301. doi: 10.1016/j.intimp.2020.106301. [Epub ahead of print

GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1α-induced eosinophilic airway inflammation.
Sokulsky LA, Goggins B, Sherwin S, Eyers F, Kaiko GE, Board PG, Keely S, Yang M, Foster PS.
Clin Exp Allergy. 2020 Feb 12. doi: 10.1111/cea.13582. [Epub ahead of print]

Rhein Suppresses Lung Inflammatory Injury Induced by Human Respiratory Syncytial Virus Through Inhibiting NLRP3 Inflammasome Activation via NF-κB Pathway in Mice.
Shen C, Zhang Z, Xie T, Ji J, Xu J, Lin L, Yan J, Kang A, Dai Q, Dong Y, Shan J, Wang S, Zhao X.
Front Pharmacol. 2020 Jan 28;10:1600. doi: 10.3389/fphar.2019.01600. eCollection 2019.

NecroX-5 alleviate lipopolysaccharide-induced acute respiratory distress syndrome by inhibiting TXNIP/NLRP3 and NF-κB.
Fang XZ, Ge YL, Chen ZY, Shu HQ, Yang YY, Yu Y, Zhou XJ, Chen L, Cui SN, Wang YX, Yao SL, Shang Y.
Int Immunopharmacol. 2020 Feb 7;81:106257. doi: 10.1016/j.intimp.2020.106257. [Epub ahead of print]

Mouse pulmonary dose- and time course-responses induced by exposure to nitrogen-doped multi-walled carbon nanotubes.
Porter DW, Orandle M, Zheng P, Wu N, Hamilton RF Jr, Holian A, Chen BT, Andrew M, Wolfarth MG, Battelli L, Tsuruoka S, Terrones M, Castranova V.
Inhal Toxicol. 2020 Jan;32(1):24-38. doi: 10.1080/08958378.2020.1723746. Epub 2020 Feb 7

Exosomal miRNA Let-7 from Menstrual Blood-Derived Endometrial Stem Cells Alleviates Pulmonary Fibrosis through Regulating Mitochondrial DNA Damage.
Sun L, Zhu M, Feng W, Lin Y, Yin J, Jin J, Wang Y.
Oxid Med Cell Longev. 2019 Dec 16;2019:4506303. doi: 10.1155/2019/4506303. eCollection 2019.

The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation.
Huppertz C, Jäger B, Wieczorek G, Engelhard P, Oliver SJ, Bauernfeind FG, Littlewood-Evans A, Welte T, Hornung V, Prasse A.
Eur Respir J. 2020 Mar 26;55(3). pii: 1900119. doi: 10.1183/13993003.00119-2019. Print 2020 Mar.

Resveratrol protects human bronchial epithelial cells against nickel-induced toxicity via suppressing p38 MAPK, NF-κB signaling, and NLRP3 inflammasome activation.
Cao X, Tian S, Fu M, Li Y, Sun Y, Liu J, Liu Y.
Environ Toxicol. 2020 May;35(5):609-618. doi: 10.1002/tox.22896. Epub 2020 Jan 13.

Nonlinear dose-time-response functions and health-protective exposure limits for inflammation-mediated diseases.
Cox LA Jr.
Environ Res. 2020 Mar;182:109026. doi: 10.1016/j.envres.2019.109026. Epub 2019 Dec 16.

Ghrelin alleviates traumatic brain injury-induced acute lung injury through pyroptosis/NF-κB pathway.
Shao XF, Li B, Shen J, Wang QF, Chen SS, Jiang XC, Qiang D.
Int Immunopharmacol. 2020 Feb;79:106175. doi: 10.1016/j.intimp.2019.106175. Epub 2020 Jan 6

Dose-response modeling of NLRP3 inflammasome-mediated diseases: asbestos, lung cancer, and malignant mesothelioma as examples.
Cox LA Jr.
Crit Rev Toxicol. 2019 Aug;49(7):614-635. doi: 10.1080/10408444.2019.1692779. Epub 2020 Jan 6. Review.

Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β-mediated colitis.
Mao L, Kitani A, Hiejima E, Montgomery-Recht K, Zhou W, Fuss I, Wiestner A, Strober W.
J Clin Invest. 2020 Apr 1;130(4):1793-1807. doi: 10.1172/JCI128322.

NALP3 orchestrates cellular bioenergetics to facilitate non-small cell lung cancer cell growth.
He ZF, Jin XR, Lin JJ, Zhang X, Liu Y, Xu HL, Xie DY.
Life Sci. 2020 Jan 15;241:117165. doi: 10.1016/j.lfs.2019.117165. Epub 2019 Dec 12.

Particulate matters induce acute exacerbation of allergic airway inflammation via the TLR2/NF-κB/NLRP3 signaling pathway.
Dai MY, Chen FF, Wang Y, Wang MZ, Lv YX, Liu RY.
Toxicol Lett. 2020 Mar 15;321:146-154. doi: 10.1016/j.toxlet.2019.12.013. Epub 2019 Dec 10.

Anti-inflammatory effect of Yam Glycoprotein on lipopolysaccharide-induced acute lung injury via the NLRP3 and NF-κB/TLR4 signaling pathway.
Niu X, Zang L, Li W, Xiao X, Yu J, Yao Q, Zhao J, Ye Z, Hu Z, Li W.
Int Immunopharmacol. 2020 Apr;81:106024. doi: 10.1016/j.intimp.2019.106024. Epub 2019 Nov 26.

Dexamethasone alleviate allergic airway inflammation in mice by inhibiting the activation of NLRP3inflammasome.
Guan M, Ma H, Fan X, Chen X, Miao M, Wu H.
Int Immunopharmacol. 2020 Jan;78:106017. doi: 10.1016/j.intimp.2019.106017. Epub 2019 Nov 25.

The HO-1 Signal Prevents HMGB1-Mediated Activation of NLRP3 Inflammasomes in Lipopolysaccharide-Induced Acute Lung Injury In Vitro.
Luo M, Hong XQ, Zhu H, Li G, Tang L.
J Surg Res. 2020 Mar;247:335-343. doi: 10.1016/j.jss.2019.10.011. Epub 2019 Nov 22.

Activation of NLRP3 inflammasome by lymphocytic microparticles via TLR4 pathway contributes to airway inflammation.
Qiu Q, Yang Z, Cao F, Yang C, Hardy P, Yan X, Yang S, Xiong W.
Exp Cell Res. 2020 Jan 15;386(2):111737. doi: 10.1016/j.yexcr.2019.111737. Epub 2019 Nov 20.

Pleural mesothelioma and lung cancer: the role of asbestos exposure and genetic variants in selected iron metabolism and inflammation genes.
Celsi F, Crovella S, Moura RR, Schneider M, Vita F, Finotto L, Zabucchi G, Zacchi P, Borelli
J Toxicol Environ Health A. 2019;82(20):1088-1102. doi: 10.1080/15287394.2019.1694612. Epub 2019 Nov 22.

Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome.
Wu HM, Xie QM, Zhao CC, Xu J, Fan XY, Fei GH.
Life Sci. 2019 Dec 15;239:117067. doi: 10.1016/j.lfs.2019.117067. Epub 2019 Nov 16.

Unique synergistic antiviral effects of Shufeng Jiedu Capsule and oseltamivir in influenza A viral-induced acute exacerbation of chronic obstructive pulmonary disease
Ji S, Bai Q, Wu X, Zhang DW, Wang S, Shen JL, Fei GH.
Biomed Pharmacother. 2020 Jan;121:109652. doi: 10.1016/j.biopha.2019.109652. Epub 2019 Nov 14.

Vasoactive intestinal peptide suppresses the NLRP3 inflammasome activation in lipopolysaccharide-induced acute lung injury mice and macrophages.
Zhou Y, Zhang CY, Duan JX, Li Q, Yang HH, Sun CC, Zhang J, Luo XQ, Liu SK.
Biomed Pharmacother. 2020 Jan;121:109596. doi: 10.1016/j.biopha.2019.109596. Epub 2019 Nov 12

Nano-Antagonist Alleviates Inflammation and Allows for MRI of Atherosclerosis.
Mog B, Asase C, Chaplin A, Gao H, Rajagopalan S, Maiseyeu A.
Nanotheranostics. 2019 Nov 1;3(4):342-355. doi: 10.7150/ntno.37391. eCollection 2019.

Carbon black nanoparticles induce pulmonary fibrosis through NLRP3 inflammasome pathway modulated by miR-96 targeted FOXO3a.
Zhou L, Li P, Zhang M, Han B, Chu C, Su X, Li B, Kang H, Ning J, Zhang B, Ma S, Su D, Pang Y, Niu Y, Zhang R.
Chemosphere. 2020 Feb;241:125075. doi: 10.1016/j.chemosphere.2019.125075. Epub 2019 Oct 11.

Cellular mechanisms underlying steroid-resistant asthma.
Wadhwa R, Dua K, Adcock IM, Horvat JC, Kim RY, Hansbro PM.
Eur Respir Rev. 2019 Oct 21;28(153). pii: 190096. doi: 10.1183/16000617.0096-2019. Print 2019 Sep 30. Review. Erratum in: Eur Respir Rev. 2019 Nov 13;28(154):.

[Molecular Mechanism of Ventilator-associated Lung Injury Based on Keap1/Nfr2/ARE Signaling Pathway].
Xu BS, Liu HT, Ye GD, Cao HC, Mo CL, Tong GQ, Tan YY, Xu X.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 May;50(3):317-322. Chinese.

ZBP1 governs the inflammasome-independent IL-1α and neutrophil inflammation that play a dual role in anti-influenza virus immunity.
Momota M, Lelliott P, Kubo A, Kusakabe T, Kobiyama K, Kuroda E, Imai Y, Akira S, Coban C, Ishii KJ.
Int Immunol. 2020 Mar 7;32(3):203-212. doi: 10.1093/intimm/dxz070.

Electroacupuncture ameliorates cardiopulmonary bypass induced apoptosis in lung via ROS/Nrf2/NLRP3 inflammasome pathway.
Dhar R, Zhang L, Li Y, Rana MN, Hu Z, Li Z, Cui H, Tang H.
Life Sci. 2019 Dec 1;238:116962. doi: 10.1016/j.lfs.2019.116962. Epub 2019 Oct 16.

Targeting NLRP3 Inflammasome Activation in Severe Asthma.
Theofani E, Semitekolou M, Morianos I, Samitas K, Xanthou G.
J Clin Med. 2019 Oct 4;8(10). pii: E1615. doi: 10.3390/jcm8101615. Review.

Is NLRP3 or NLRP6 inflammasome activation associated with inflammation-related lungtumorigenesis induced by benzo(a)pyrene and lipopolysaccharide?
Gao M, Zhang P, Huang L, Shao H, Duan S, Li C, Zhang Q, Wang W, Wu Y, Wang J, Liu H, Feng F.
Ecotoxicol Environ Saf. 2019 Dec 15;185:109687. doi: 10.1016/j.ecoenv.2019.109687. Epub 2019 Sep 24.

Prevention of crystalline silica-induced inflammation by the anti-malarial hydroxychloroquine.
Burmeister R, Rhoderick JF, Holian A.
Inhal Toxicol. 2019 Jun;31(7):274-284. doi: 10.1080/08958378.2019.1668091. Epub 2019 Sep 26.

Oridonin attenuates carrageenan-induced pleurisy via activation of the KEAP-1/Nrf2 pathway and inhibition of the TXNIP/NLRP3 and NF-κB pathway in mice
Yang H, Huang J, Gao Y, Wen Z, Peng L, Ci X.
Inflammopharmacology. 2020 Apr;28(2):513-523. doi: 10.1007/s10787-019-00644-y. Epub 2019 Sep 25.

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis.
Scambler T, Jarosz-Griffiths HH, Lara-Reyna S, Pathak S, Wong C, Holbrook J, Martinon F, Savic S, Peckham D, McDermott MF.
Elife. 2019 Sep 18;8. pii: e49248. doi: 10.7554/eLife.49248.

Methanogenic Archaea: Emerging Partners in the Field of Allergic Diseases.
Sereme Y, Mezouar S, Grine G, Mege JL, Drancourt M, Corbeau P, Vitte J.
Clin Rev Allergy Immunol. 2019 Dec;57(3):456-466. doi: 10.1007/s12016-019-08766-5. Review.

Suppression of NLRP3 and NF-κB signaling pathways by α-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice.
Liu X, Jin X, Yu D, Liu G.
Int Immunopharmacol. 2019 Nov;76:105886. doi: 10.1016/j.intimp.2019.105886. Epub 2019 Sep 11.

Syk-dependent glycolytic reprogramming in dendritic cells regulates IL-1β production to β-glucan ligands in a TLR-independent manner.
Thwe PM, Fritz DI, Snyder JP, Smith PR, Curtis KD, O’Donnell A, Galasso NA, Sepaniac LA, Adamik BJ, Hoyt LR, Rodriguez PD, Hogan TC, Schmidt AF, Poynter ME, Amiel E.
J Leukoc Biol. 2019 Dec;106(6):1325-1335. doi: 10.1002/JLB.3A0819-207RR. Epub 2019 Sep 11.

Cystic Fibrosis Lung Disease and Immunometabolism. Targeting the NLRP3 Inflammasome.
Cantin AM.
Am J Respir Crit Care Med. 2019 Dec 1;200(11):1335-1337. doi: 10.1164/rccm.201908-1558ED. No abstract available.

Curcumin relieves paraquat‑induced lung injury through inhibiting the thioredoxin interacting protein/NLR pyrin domain containing 3‑mediated inflammatory pathway.
Ren Y, Yang Z, Sun Z, Zhang W, Chen X, Nie S.
Mol Med Rep. 2019 Dec;20(6):5032-5040. doi: 10.3892/mmr.2019.10612. Epub 2019 Aug 23.

NACHT, LRR, and PYD domains-containing Protein 3 and LL-37: prognostic value of new biomarkers in community-acquired pneumonia.
Zhu C, Zhou Y, Zhu J, Liu Y, Sun M.
J Bras Pneumol. 2019 Aug 29;45(4):e20190001. doi: 10.1590/1806-3713/e20190001. Portuguese, English.

NLRP3 inflammasome is attenuated in patients with Mycobacterium avium complex lung disease and correlated with decreased interleukin-1β response and host susceptibility.
Wu MF, Shu CC, Wang JY, Yan BS, Lai HC, Chiang BL, Wu LS, Yu CJ.
Sci Rep. 2019 Aug 29;9(1):12534. doi: 10.1038/s41598-019-47609-3.

Specific Inhibition of the NLRP3 Inflammasome as an Antiinflammatory Strategy in Cystic Fibrosis.
McElvaney OJ, Zaslona Z, Becker-Flegler K, Palsson-McDermott EM, Boland F, Gunaratnam C, Gulbins E, O’Neill LA, Reeves EP, McElvaney NG.
Am J Respir Crit Care Med. 2019 Dec 1;200(11):1381-1391. doi: 10.1164/rccm.201905-1013OC.

Astragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1/NLRP3 inflammasome pathway.
Qian W, Cai X, Qian Q, Zhuang Q, Yang W, Zhang X, Zhao L.
Drug Des Devel Ther. 2019 Jul 29;13:2579-2589. doi: 10.2147/DDDT.S207774. eCollection 2019.

Apocynin alleviates lung injury by suppressing NLRP3 inflammasome activation and NF-κB signaling in acute pancreatitis.
Jin HZ, Yang XJ, Zhao KL, Mei FC, Zhou Y, You YD, Wang WX.
Int Immunopharmacol. 2019 Oct;75:105821. doi: 10.1016/j.intimp.2019.105821. Epub 2019 Aug 19.

HIF‑1α promotes NLRP3 inflammasome activation in bleomycin‑induced acute lung injury.
Huang JJ, Xia J, Huang LL, Li YC.
Mol Med Rep. 2019 Oct;20(4):3424-3432. doi: 10.3892/mmr.2019.10575. Epub 2019 Aug 8.

Oxidative stress promotes ventilator-induced lung injury through activating NLRP3 inflammasome and TRPM2 channel.
An X, Sun X, Yang X, Liu D, Hou Y, Chen H, Wu J.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3448-3455. doi: 10.1080/21691401.2019.165263

Attenuation of hyperoxic acute lung injury by Lycium barbarum polysaccharide via inhibiting NLRP3inflammasome.
Hong CY, Zhang HD, Liu XY, Xu Y.
Arch Pharm Res. 2019 Oct;42(10):902-908. doi: 10.1007/s12272-019-01175-4. Epub 2019 Aug 6.

Pulmonary inflammation induced by low-dose particulate matter exposure in mice.
Chan YL, Wang B, Chen H, Ho KF, Cao J, Hai G, Jalaludin B, Herbert C, Thomas PS, Saad S, Oliver BGG.
Am J Physiol Lung Cell Mol Physiol. 2019 Sep 1;317(3):L424-L430. doi: 10.1152/ajplung.00232.2019. Epub 2019 Jul 31.

Defining Bronchial Asthma with Phosphoinositide 3-Kinase Delta Activation: Towards Endotype-Driven Management.
Jeong JS, Kim JS, Kim SR, Lee YC.
Int J Mol Sci. 2019 Jul 18;20(14). pii: E3525. doi: 10.3390/ijms20143525. Review.

Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.
Qin W, Wu X, Jia Y, Tong X, Guo C, Chen D, Wang Z, Tan N.
Biomed Pharmacother. 2019 Oct;118:109188. doi: 10.1016/j.biopha.2019.109188. Epub 2019 Jul 14.

Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD.
Tien CP, Chen CH, Lin WY, Liu CS, Liu KJ, Hsiao M, Chang YC, Hung SC.
Aging (Albany NY). 2019 Jul 12;11(13):4654-4671. doi: 10.18632/aging.102077.

Resveratrol alleviates chronic “real-world” ambient particulate matter-induced lung inflammation and fibrosis by inhibiting NLRP3 inflammasome activation in mice.
Ding S, Wang H, Wang M, Bai L, Yu P, Wu W.
Ecotoxicol Environ Saf. 2019 Oct 30;182:109425. doi: 10.1016/j.ecoenv.2019.109425. Epub 2019 Jul 8.

TRPV1 and TRPA1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PM2.5).
Xu M, Zhang Y, Wang M, Zhang H, Chen Y, Adcock IM, Chung KF, Mo J, Zhang Y, Li F.
Oxid Med Cell Longev. 2019 Jun 2;2019:7450151. doi: 10.1155/2019/7450151. eCollection 2019.

ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism.
Fang R, Uchiyama R, Sakai S, Hara H, Tsutsui H, Suda T, Mitsuyama M, Kawamura I, Tsuchiya K.
Mucosal Immunol. 2019 Sep;12(5):1092-1103. doi: 10.1038/s41385-019-0181-1. Epub 2019 Jul 5.

Identification of long non-coding RNA and circular RNA in mice after intra-tracheal instillation with fine particulate matter.
Zhong Y, Wang Y, Zhang C, Hu Y, Sun C, Liao J, Wang G.
Chemosphere. 2019 Nov;235:519-526. doi: 10.1016/j.chemosphere.2019.06.122. Epub 2019 Jun 17.

Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection.
Rosli S, Kirby FJ, Lawlor KE, Rainczuk K, Drummond GR, Mansell A, Tate MD.
Br J Pharmacol. 2019 Oct;176(19):3834-3844. doi: 10.1111/bph.14787. Epub 2019 Aug 19.

Increased extracellular vesicle miRNA-466 family in the bronchoalveolar lavage fluid as a precipitating factor of ARDS.
Shikano S, Gon Y, Maruoka S, Shimizu T, Kozu Y, Iida Y, Hikichi M, Takahashi M, Okamoto S, Tsuya K, Fukuda A, Mizumura K, Hashimoto S.
BMC Pulm Med. 2019 Jun 20;19(1):110. doi: 10.1186/s12890-019-0876-9.

Evaluation of Canonical Inflammasome Activation in Human Monocytes by Imaging Flow Cytometry.
Lage SL, Dominical VM, Wong CS, Sereti I.
Front Immunol. 2019 Jun 4;10:1284. doi: 10.3389/fimmu.2019.01284. eCollection 2019.

Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways.
Yang H, Lv H, Li H, Ci X, Peng L.
Cell Commun Signal. 2019 Jun 11;17(1):62. doi: 10.1186/s12964-019-0366-y.

Mitochondrial ROS and NLRP3 inflammasome in acute ozone-induced murine model of airway inflammation and bronchial hyperresponsiveness.
Xu M, Wang L, Wang M, Wang H, Zhang H, Chen Y, Wang X, Gong J, Zhang JJ, Adcock IM, Chung KF, Li F.
Free Radic Res. 2019 Jul;53(7):780-790. doi: 10.1080/10715762.2019.1630735. Epub 2019 Jun 27.

Risk Analysis Implications of Dose-Response Thresholds for NLRP3 Inflammasome-Mediated Diseases: Respirable Crystalline Silica and Lung Cancer as an Example.
Cox LAT Jr.
Dose Response. 2019 Apr 2;17(2):1559325819836900. doi: 10.1177/1559325819836900. eCollection 2019 Apr-Jun.

The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity.
Li XX, Lee JD, Kemper C, Woodruff TM.
J Immunol. 2019 Jun 15;202(12):3339-3348. doi: 10.4049/jimmunol.1900371. Review.

Carbon monoxide releasing molecule-2 protects against particulate matter-induced lung inflammation by inhibiting TLR2 and 4/ROS/NLRP3 inflammasome activation.
Lee CW, Chi MC, Hsu LF, Yang CM, Hsu TH, Chuang CC, Lin WN, Chu PM, Lee IT.
Mol Immunol. 2019 Aug;112:163-174. doi: 10.1016/j.molimm.2019.05.005. Epub 2019 May 29.

Rev-erbα can regulate the NF-κB/NALP3 pathway to modulate lipopolysaccharide-induced acute lunginjury and inflammation.
Yu D, Fang X, Xu Y, Xiao H, Huang T, Zhang Y, Ge Y, Li Y, Zong L, Gao J.
Int Immunopharmacol. 2019 Aug;73:312-320. doi: 10.1016/j.intimp.2019.04.035. Epub 2019 May 23.

Glibenclamide alleviates inflammation in oleic acid model of acute lung injury through NLRP3inflammasome signaling pathway.
Chen H, Ding Y, Chen W, Feng Y, Shi G.
Drug Des Devel Ther. 2019 May 7;13:1545-1554. doi: 10.2147/DDDT.S196040. eCollection 2019.

NLRP3 inflammasome activity is upregulated in an in-vitro model of COPD exacerbation.
Nachmias N, Langier S, Brzezinski RY, Siterman M, Stark M, Etkin S, Avriel A, Schwarz Y, Shenhar-Tsarfaty S, Bar-Shai A.
PLoS One. 2019 May 21;14(5):e0214622. doi: 10.1371/journal.pone.0214622. eCollection 2019.

Inflammasome-Independent and Atypical Processing of IL-1β Contributes to Acid Aspiration-Induced Acute Lung Injury.
Mizushina Y, Karasawa T, Aizawa K, Kimura H, Watanabe S, Kamata R, Komada T, Mato N, Kasahara T, Koyama S, Bando M, Hagiwara K, Takahashi M.
J Immunol. 2019 Jul 1;203(1):236-246. doi: 10.4049/jimmunol.1900168. Epub 2019 May 20.

Is the Inflammasome Pathway Active in the Peripheral Blood of Sulfur Mustard-exposed Patients?
Etehad Asnaf S, Sabetghadam M, Jaafarinejad H, Halabian R, Parvin S, Vahedi E, Pazoki N, Salimian J.
Iran J Allergy Asthma Immunol. 2019 Apr 1;18(2):218-224.

Baicalin tetrazole acts as anti-pneumocystis carinii pneumonia candidate in immunosuppressed rat model.
Chen L, Zhang X, Peng X, Yang Y, Yu H.
Microb Pathog. 2019 Jul;132:59-65. doi: 10.1016/j.micpath.2019.04.027. Epub 2019 Apr 16.

Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep.
Cade BE, Chen H, Stilp AM, Louie T, Ancoli-Israel S, Arens R, Barfield R, Below JE, Cai J, Conomos MP, Evans DS, Frazier-Wood AC, Gharib SA, Gleason KJ, Gottlieb DJ, Hillman DR, Johnson WC, Lederer DJ, Lee J, Loredo JS, Mei H, Mukherjee S, Patel SR, Post WS, Purcell SM, Ramos AR, Reid KJ, Rice K, Shah NA, Sofer T, Taylor KD, Thornton TA, Wang H, Yaffe K, Zee PC, Hanis CL, Palmer LJ, Rotter JI, Stone KL, Tranah GJ, Wilson JG, Sunyaev SR, Laurie CC, Zhu X, Saxena R, Lin X, Redline S.
PLoS Genet. 2019 Apr 16;15(4):e1007739. doi: 10.1371/journal.pgen.1007739. eCollection 2019 Apr.

Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3inflammasome.
Liu G, Mateer SW, Hsu A, Goggins BJ, Tay H, Mathe A, Fan K, Neal R, Bruce J, Burns G, Minahan K, Maltby S, Fricker M, Foster PS, Wark PAB, Hansbro PM, Keely S.
Mucosal Immunol. 2019 Jul;12(4):862-873. doi: 10.1038/s41385-019-0163-3. Epub 2019 Apr 11.

Human metapneumovirus activates NOD-like receptor protein 3 inflammasome via its small hydrophobic protein which plays a detrimental role during infection in mice.
Lê VB, Dubois J, Couture C, Cavanagh MH, Uyar O, Pizzorno A, Rosa-Calatrava M, Hamelin MÈ, Boivin G.
PLoS Pathog. 2019 Apr 9;15(4):e1007689. doi: 10.1371/journal.ppat.1007689. eCollection 2019 Apr.

NLRP3 inflammasome plays an important role in caspase-1 activation and IL-1β secretion in macrophages infected with Pasteurella multocida.
Fang R, Du H, Lei G, Liu Y, Feng S, Ye C, Li N, Peng Y.
Vet Microbiol. 2019 Apr;231:207-213. doi: 10.1016/j.vetmic.2019.03.019. Epub 2019 Mar 18.

Ventilator-induced lung injury is alleviated by inhibiting NLRP3 inflammasome activation.
Liu H, Gu C, Liu M, Liu G, Wang D, Liu X, Wang Y.
Mol Immunol. 2019 Jul;111:1-10. doi: 10.1016/j.molimm.2019.03.011. Epub 2019 Apr 2.

Protective effects of propofol on experimental neonatal acute lung injury.
Yu X, Li C.
Mol Med Rep. 2019 May;19(5):4507-4513. doi: 10.3892/mmr.2019.10113. Epub 2019 Apr 1.

Intranasal Application of Budesonide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Nucleotide-Binding Oligomerization Domain-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation in Mice.
Dong L, Zhu YH, Liu DX, Li J, Zhao PC, Zhong YP, Chen YQ, Xu W, Zhu ZQ.
J Immunol Res. 2019 Feb 27;2019:7264383. doi: 10.1155/2019/7264383. eCollection 2019.

The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation.
Peng XP, Li XH, Li Y, Huang XT, Luo ZQ.
Int Immunopharmacol. 2019 May;70:520-529. doi: 10.1016/j.intimp.2019.03.018. Epub 2019 Mar 19.

Dihydromyricetin Alleviates Sepsis-Induced Acute Lung Injury through Inhibiting NLRP3Inflammasome-Dependent Pyroptosis in Mice Model.
Wang YC, Liu QX, Zheng Q, Liu T, Xu XE, Liu XH, Gao W, Bai XJ, Li ZF.
Inflammation. 2019 Aug;42(4):1301-1310. doi: 10.1007/s10753-019-00990-7.

Activation of Nicotinic Acetylcholine α7 Receptor Attenuates Progression of Monocrotaline-Induced Pulmonary Hypertension in Rats by Downregulating the NLRP3 Inflammasome.
Deng Y, Guo SL, Wei B, Gao XC, Zhou YC, Li JQ.
Front Pharmacol. 2019 Feb 26;10:128. doi: 10.3389/fphar.2019.00128. eCollection 2019.

Carbon nanotubes and crystalline silica stimulate robust ROS production, inflammasome activation, and IL-1β secretion in macrophages to induce myofibroblast transformation.
Hindman B, Ma Q.
Arch Toxicol. 2019 Apr;93(4):887-907. doi: 10.1007/s00204-019-02411-y. Epub 2019 Mar 7.

Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats.
Cinar I, Sirin B, Aydin P, Toktay E, Cadirci E, Halici I, Halici Z.
Life Sci. 2019 Mar 15;221:327-334. doi: 10.1016/j.lfs.2019.02.039. Epub 2019 Feb 20.

DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma.
Jeong A, Imboden M, Ghantous A, Novoloaca A, Carsin AE, Kogevinas M, Schindler C, Lovison G, Herceg Z, Cuenin C, Vermeulen R, Jarvis D, Amaral AFS, Kronenberg F, Vineis P, Probst-Hensch N.
Int J Environ Res Public Health. 2019 Feb 19;16(4). pii: E600. doi: 10.3390/ijerph16040600.

miR-16 inhibits NLRP3 inflammasome activation by directly targeting TLR4 in acute lung injury.
Yang Y, Yang F, Yu X, Wang B, Yang Y, Zhou X, Cheng R, Xia S, Zhou X.
Biomed Pharmacother. 2019 Apr;112:108664. doi: 10.1016/j.biopha.2019.108664. Epub 2019 Feb 20.

Melatonin Alleviates Radiation-Induced Lung Injury via Regulation of miR-30e/NLRP3 Axis.
Wu X, Ji H, Wang Y, Gu C, Gu W, Hu L, Zhu L.
Oxid Med Cell Longev. 2019 Jan 10;2019:4087298. doi: 10.1155/2019/4087298. eCollection 2019.

MicroRNA‑223 attenuates LPS‑induced inflammation in an acute lung injury model via the NLRP3inflammasome and TLR4/NF‑κB signaling pathway via RHOB.
Yan Y, Lu K, Ye T, Zhang Z.
Int J Mol Med. 2019 Mar;43(3):1467-1477. doi: 10.3892/ijmm.2019.4075. Epub 2019 Jan 23.

Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary disease-induced depression: A potential mechanism underlying the cross talk between lung and brain.
Deng X, Fu J, Song Y, Xu B, Ji Z, Guo Q, Ma S.
Brain Behav Immun. 2019 Jul;79:195-206. doi: 10.1016/j.bbi.2019.02.001. Epub 2019 Feb 6.

A Novel Insight on Endotyping Heterogeneous Severe Asthma Based on Endoplasmic Reticulum Stress: Beyond the “Type 2/Non-Type 2 Dichotomy”.
Jeong JS, Kim SR, Cho SH, Lee YC.
Int J Mol Sci. 2019 Feb 7;20(3). pii: E713. doi: 10.3390/ijms20030713. Review.

Genetic inactivation of the phospholipase A2 activity of peroxiredoxin 6 in mice protects against LPS-induced acute lung injury.
Vázquez-Medina JP, Tao JQ, Patel P, Bannitz-Fernandes R, Dodia C, Sorokina EM, Feinstein SI, Chatterjee S, Fisher AB.
Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1;316(4):L656-L668. doi: 10.1152/ajplung.00344.2018. Epub 2019 Jan 31.

NLRP3 inflammasome activation involved in LPS and coal tar pitch extract-induced malignant transformation of human bronchial epithelial cells.
Duan S, Wang N, Huang L, Shao H, Zhang P, Wang W, Wu Y, Wang J, Liu H, Zhang Q, Feng F.
Environ Toxicol. 2019 May;34(5):585-593. doi: 10.1002/tox.22725. Epub 2019 Jan 30.

NLRP3 deletion inhibits inflammation-driven mouse lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide.
Huang L, Duan S, Shao H, Zhang A, Chen S, Zhang P, Wang N, Wang W, Wu Y, Wang J, Liu H, Yao W, Zhang Q, Feng F.
Respir Res. 2019 Jan 29;20(1):20. doi: 10.1186/s12931-019-0983-4.

Electroacupuncture Pretreatment Attenuates Inflammatory Lung Injury After Cardiopulmonary Bypass by Suppressing NLRP3 Inflammasome Activation in Rats.
Huang D, Chen M, Wang Z, Hou L, Yu W.
Inflammation. 2019 Jun;42(3):895-903. doi: 10.1007/s10753-018-0944-y.

Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3inflammasome suppression.
Xu WJ, Wang XX, Jin JJ, Zou Q, Wu L, Lv TF, Wan B, Zhan P, Zhu SH, Liu HB, Zhao NW, Li CJ, Song Y.
Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L567-L577. doi: 10.1152/ajplung.00190.2018. Epub 2019 Jan 17.

[Expression and significance of NLRP3/IL-1β/TGF-β(1) signal axis in rat model of silicosis pulmonary fibrosis].
Song ZS, Shao H, Chen YQ, Zhang R.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018 Nov 20;36(11):819-823. doi: 10.3760/cma.j.issn.1001-9391.2018.11.005. Chinese.

Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model.
Wang M, Zhang Y, Xu M, Zhang H, Chen Y, Chung KF, Adcock IM, Li F.
Free Radic Biol Med. 2019 Apr;134:229-238. doi: 10.1016/j.freeradbiomed.2019.01.004. Epub 2019 Jan 9.

NLRP3 Deficiency Alleviates Severe Acute Pancreatitis and Pancreatitis-Associated Lung Injury in a Mouse Model.
Fu Q, Zhai Z, Wang Y, Xu L, Jia P, Xia P, Liu C, Zhang X, Qin T, Zhang H.
Biomed Res Int. 2018 Nov 28;2018:1294951. doi: 10.1155/2018/1294951. eCollection 2018.

MiR-24 inhibits inflammatory responses in LPS-induced acute lung injury of neonatal rats through targeting NLRP3.
Lin Y, Yang Y.
Pathol Res Pract. 2019 Apr;215(4):683-688. doi: 10.1016/j.prp.2018.12.028. Epub 2018 Dec 26

Inhibition of NLRP3 inflammasome attenuates spinal cord injury-induced lung injury in mice.
Jiang W, Li M, He F, Zhu L.
J Cell Physiol. 2019 May;234(5):6012-6022. doi: 10.1002/jcp.27233. Epub 2018 Dec 27.

Charcot-Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1β Inflammation in Human Macrophages.
Rodríguez-Alcázar JF, Ataide MA, Engels G, Schmitt-Mabmunyo C, Garbi N, Kastenmüller W, Latz E, Franklin BS.
J Immunol. 2019 Jan 15;202(2):550-558. doi: 10.4049/jimmunol.1800107. Epub 2018 Dec 17.

Rapamycin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting IL-1β and IL-18 production.
Jia X, Cao B, An Y, Zhang X, Wang C.
Int Immunopharmacol. 2019 Feb;67:211-219. doi: 10.1016/j.intimp.2018.12.017. Epub 2018 Dec 15.

Granisetron protects polymicrobial sepsis-induced acute lung injury in mice.
Wang J, Gong S, Wang F, Niu M, Wei G, He Z, Gu T, Jiang Y, Liu A, Chen P.
Biochem Biophys Res Commun. 2019 Jan 22;508(4):1004-1010. doi: 10.1016/j.bbrc.2018.12.031. Epub 2018 Dec 11.

Peroxisome Proliferator Activated Receptor gamma (PPARγ) Agonist Rosiglitazone Ameliorate Airway Inflammation by Inhibiting Toll-Like Receptor 2 (TLR2)/Nod-Like Receptor with Pyrin Domain Containing 3 (NLRP3) Inflammatory Corpuscle Activation in Asthmatic Mice.
Cheng Y, Li S, Wang M, Cheng C, Liu R.
Med Sci Monit. 2018 Dec 13;24:9045-9053. doi: 10.12659/MSM.910766.

Fraxin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting the NF-κB and NLRP3 signallingpathways.
Li W, Li W, Zang L, Liu F, Yao Q, Zhao J, Zhi W, Niu X.
Int Immunopharmacol. 2019 Feb;67:1-12. doi: 10.1016/j.intimp.2018.12.003. Epub 2018 Dec 6.

Proteomic Profiling of LPS-Induced Macrophage-Derived Exosomes Indicates Their Involvement in Acute Liver Injury.
Wang G, Jin S, Ling X, Li Y, Hu Y, Zhang Y, Huang Y, Chen T, Lin J, Ning Z, Meng Y, Li X.
Proteomics. 2019 Feb;19(3):e1800274. doi: 10.1002/pmic.201800274. Epub 2018 Dec 27.

Withaferin A attenuates ovalbumin induced airway inflammation.
Zhao HM, Gao ZW, Xie SX, Han X, Sun QS.
Front Biosci (Landmark Ed). 2019 Jan 1;24:576-596.

Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozone-induced lung inflammation and emphysema.
Li F, Xu M, Wang M, Wang L, Wang H, Zhang H, Chen Y, Gong J, Zhang JJ, Adcock IM, Chung KF, Zhou X.
Respir Res. 2018 Nov 22;19(1):230. doi: 10.1186/s12931-018-0931-8.

Chicoric acid alleviates lipopolysaccharide-induced acute lung injury in mice through anti-inflammatory and anti-oxidant activities.
Ding H, Ci X, Cheng H, Yu Q, Li D.
Int Immunopharmacol. 2019 Jan;66:169-176. doi: 10.1016/j.intimp.2018.10.042. Epub 2018 Nov 19.

IL-1R and Inflammasomes Mediate Early Pulmonary Protective Mechanisms in Respiratory Brucella Abortus Infection.
Hielpos MS, Fernández AG, Falivene J, Alonso Paiva IM, Muñoz González F, Ferrero MC, Campos PC, Vieira AT, Oliveira SC, Baldi PC.
Front Cell Infect Microbiol. 2018 Nov 5;8:391. doi: 10.3389/fcimb.2018.00391. eCollection 2018.

The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury.
Zhang Y, Wang L, Lv Y, Jiang C, Wu G, Dull RO, Minshall RD, Malik AB, Hu G.
J Immunol. 2019 Jan 1;202(1):194-206. doi: 10.4049/jimmunol.1800777. Epub 2018 Nov 19.

Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration.
Jia X, Liu B, Bao L, Lv Q, Li F, Li H, An Y, Zhang X, Cao B, Wang C.
PLoS Pathog. 2018 Nov 13;14(11):e1007428. doi: 10.1371/journal.ppat.1007428. eCollection 2018 Nov.

New insights in neutrophilic asthma.
Seys SF, Lokwani R, Simpson JL, Bullens DMA.
Curr Opin Pulm Med. 2019 Jan;25(1):113-120. doi: 10.1097/MCP.0000000000000543. Review.

Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness.
Xu M, Li F, Wang M, Zhang H, Xu L, Adcock IM, Chung KF, Zhang Y.
Eur J Pharmacol. 2019 Jan 5;842:373-383. doi: 10.1016/j.ejphar.2018.11.010. Epub 2018 Nov 9

Laurus nobilis leaf extract controls inflammation by suppressing NLRP3 inflammasome activation.
Lee EH, Shin JH, Kim SS, Lee H, Yang SR, Seo SR.
J Cell Physiol. 2019 May;234(5):6854-6864. doi: 10.1002/jcp.27434. Epub 2018 Nov 1.

Estrogen ameliorates allergic airway inflammation by regulating activation of NLRP3 in mice.
Cheng C, Wu H, Wang M, Wang L, Zou H, Li S, Liu R.
Biosci Rep. 2019 Jan 8;39(1). pii: BSR20181117. doi: 10.1042/BSR20181117. Print 2019 Jan 31.

NLRP3/Caspase-1 inflammasome activation is decreased in alveolar macrophages in patients with lung cancer.
Lasithiotaki I, Tsitoura E, Samara KD, Trachalaki A, Charalambous I, Tzanakis N, Antoniou KM.
PLoS One. 2018 Oct 26;13(10):e0205242. doi: 10.1371/journal.pone.0205242. eCollection 2018

Sevoflurane Inhibits the Th2 Response and NLRP3 Expression in Murine Allergic Airway Inflammation.
Wang L, Zha B, Shen Q, Zou H, Cheng C, Wu H, Liu R.
J Immunol Res. 2018 Sep 30;2018:9021037. doi: 10.1155/2018/9021037. eCollection 2018.

Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory NLRP3-RXR axis in asthma.
Lv J, Su W, Yu Q, Zhang M, Di C, Lin X, Wu M, Xia Z.
J Biol Chem. 2018 Nov 30;293(48):18454-18465. doi: 10.1074/jbc.RA118.004950. Epub 2018 Oct 17

The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase.
Vogel S, Arora T, Wang X, Mendelsohn L, Nichols J, Allen D, Shet AS, Combs CA, Quezado ZMN, Thein SL.
Blood Adv. 2018 Oct 23;2(20):2672-2680. doi: 10.1182/bloodadvances.2018021709.

[The effects of methylprednisolone on NLRP3 inflammasome in rats with acute lung injury Induced by Phosgene].
Zhou FQ, He DK, Shao YR, Shen J.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018 Aug 20;36(8):573-579. doi: 10.3760/cma.j.issn.1001-9391.2018.08.003. Chinese.

Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism.
Arbore G, West EE, Rahman J, Le Friec G, Niyonzima N, Pirooznia M, Tunc I, Pavlidis P, Powell N, Li Y, Liu P, Servais A, Couzi L, Fremeaux-Bacchi V, Placais L, Ferraro A, Walsh PR, Kavanagh D, Afzali B, Lavender P, Lachmann HJ, Kemper C.
Nat Commun. 2018 Oct 10;9(1):4186. doi: 10.1038/s41467-018-06706-z.

TREM-1 Attenuates RIPK3-mediated Necroptosis in Hyperoxia-induced Lung Injury in Neonatal Mice.
Syed MA, Shah D, Das P, Andersson S, Pryhuber G, Bhandari V.
Am J Respir Cell Mol Biol. 2019 Mar;60(3):308-322. doi: 10.1165/rcmb.2018-0219OC.

Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice.
Tan HT, Hagner S, Ruchti F, Radzikowska U, Tan G, Altunbulakli C, Eljaszewicz A, Moniuszko M, Akdis M, Akdis CA, Garn H, Sokolowska M.
Allergy. 2019 Feb;74(2):294-307. doi: 10.1111/all.13619. Epub 2018 Nov 5.

Protective effects of ethyl acetate extracts of Rimulus Cinnamon on systemic inflammation and lunginjury in endotoxin-poisoned mice.
Xu F, Sang W, Li L, He X, Wang F, Wen T, Zeng N.
Drug Chem Toxicol. 2019 May;42(3):309-316. doi: 10.1080/01480545.2018.1509987. Epub 2018 Sep 27.

Adenovirus-delivered angiopoietin-1 ameliorates phosgene-induced acute lung injury via inhibition of NLRP3 inflammasome activation.
He DK, Chen JF, Shao YR, Zhou FQ, Shen J.
Inhal Toxicol. 2018 Mar – Apr;30(4-5):187-194. doi: 10.1080/08958378.2018.1492648.

Inhibition of glycolysis alleviates lipopolysaccharide-induced acute lung injury in a mouse model.
Zhong WJ, Yang HH, Guan XX, Xiong JB, Sun CC, Zhang CY, Luo XQ, Zhang YF, Zhang J, Duan JX, Zhou Y, Guan CX.
J Cell Physiol. 2019 Apr;234(4):4641-4654. doi: 10.1002/jcp.27261. Epub 2018 Sep 7.

Apelin-13 Administration Protects Against LPS-Induced Acute Lung Injury by Inhibiting NF-κB Pathway and NLRP3 Inflammasome Activation.
Zhang H, Chen S, Zeng M, Lin D, Wang Y, Wen X, Xu C, Yang L, Fan X, Gong Y, Zhang H, Kong X.
Cell Physiol Biochem. 2018;49(5):1918-1932. doi: 10.1159/000493653. Epub 2018 Sep 20.

Polydatin suppresses proliferation and metastasis of non-small cell lung cancer cells by inhibiting NLRP3 inflammasome activation via NF-κB pathway.
Zou J, Yang Y, Yang Y, Liu X.
Biomed Pharmacother. 2018 Dec;108:130-136. doi: 10.1016/j.biopha.2018.09.051. Epub 2018 Sep 13

Microbial metabolite sensor GPR43 controls severity of experimental GVHD.
Fujiwara H, Docampo MD, Riwes M, Peltier D, Toubai T, Henig I, Wu SJ, Kim S, Taylor A, Brabbs S, Liu C, Zajac C, Oravecz-Wilson K, Sun Y, Núñez G, Levine JE, van den Brink MRM, Ferrara JLM, Reddy P.
Nat Commun. 2018 Sep 10;9(1):3674. doi: 10.1038/s41467-018-06048-w.

SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death.
Yue Y, Nabar NR, Shi CS, Kamenyeva O, Xiao X, Hwang IY, Wang M, Kehrl JH.
Cell Death Dis. 2018 Sep 5;9(9):904. doi: 10.1038/s41419-018-0917-y.

Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials.
Felley-Bosco E, MacFarlane M.
Chem Res Toxicol. 2018 Oct 15;31(10):994-1008. doi: 10.1021/acs.chemrestox.8b00146. Epub 2018 Sep 12.

Complement regulatory protein CD46 induces autophagy against oxidative stress-mediated apoptosis in normal and asthmatic airway epithelium.
Tsai YG, Wen YS, Wang JY, Yang KD, Sun HL, Liou JH, Lin CY.
Sci Rep. 2018 Aug 28;8(1):12973. doi: 10.1038/s41598-018-31317-5.

Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury.
Li D, Ren W, Jiang Z, Zhu L.
Mol Med Rep. 2018 Nov;18(5):4399-4409. doi: 10.3892/mmr.2018.9427. Epub 2018 Aug 24.

The selective Nlrp3 inflammasome inhibitor Mcc950 attenuates lung ischemia-reperfusion injury.
Xu KY, Wu CY, Tong S, Xiong P, Wang SH.
Biochem Biophys Res Commun. 2018 Sep 18;503(4):3031-3037. doi: 10.1016/j.bbrc.2018.08.089. Epub 2018 Aug 23.

Commensal bacteria aggravate allergic asthma via NLRP3/IL-1β signaling in post-weaning mice.
Huang C, Wang J, Zheng X, Chen Y, Zhou R, Wei H, Sun R, Tian Z.
J Autoimmun. 2018 Sep;93:104-113. doi: 10.1016/j.jaut.2018.07.003. Epub 2018 Jul 7.

RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice.
Chen J, Wang S, Fu R, Zhou M, Zhang T, Pan W, Yang N, Huang Y.
J Transl Med. 2018 Aug 20;16(1):233. doi: 10.1186/s12967-018-1606-4

An ethnobotanical survey and inhibitory effects on NLRP3 inflammasomes/Caspase-1 of herbal recipes’ extracts traditionally used in Rwanda for asthma treatment.
Tomani JCD, Gainkam LOT, Nshutiyayesu S, Mukazayire MJ, Ribeiro SO, Stevigny C, Frederich M, Muganga R, Souopgui J.
J Ethnopharmacol. 2018 Dec 5;227:29-40. doi: 10.1016/j.jep.2018.08.016. Epub 2018 Aug 14.

Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non‑small cell lungcancer.
Gao J, Qiu X, Xi G, Liu H, Zhang F, Lv T, Song Y.
Oncol Rep. 2018 Oct;40(4):1971-1984. doi: 10.3892/or.2018.6634. Epub 2018 Aug 7.

C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation.
Richter K, Sagawe S, Hecker A, Küllmar M, Askevold I, Damm J, Heldmann S, Pöhlmann M, Ruhrmann S, Sander M, Schlüter KD, Wilker S, König IR, Kummer W, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz AT, Koch C, Grau V.
Front Immunol. 2018 Jul 30;9:1604. doi: 10.3389/fimmu.2018.01604. eCollection 2018.

The anti-inflammatory effect of BML-111 on COPD may be mediated by regulating NLRP3inflammasome activation and ROS production.
Cao Y, Zhou X, Yin Z, Yu X, Yang Q, Guo Q, Tian D, Xiong X, Xu G, Kuang X.
Prostaglandins Other Lipid Mediat. 2018 Sep;138:23-30. doi: 10.1016/j.prostaglandins.2018.08.001. Epub 2018 Aug 10.

Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury by targeting NLRP3 via miR-381.
Zhang Y, Wang X, Liu Z, Yu L.
J Biochem Mol Toxicol. 2018 Nov;32(11):e22211. doi: 10.1002/jbt.22211. Epub 2018 Aug 13.

Swine Influenza Virus Induces RIPK1/DRP1-Mediated Interleukin-1 Beta Production.
Park HS, Liu G, Liu Q, Zhou Y.
Viruses. 2018 Aug 9;10(8). pii: E419. doi: 10.3390/v10080419.

Kinome analyses of inflammatory responses to swine barn dust extract in human bronchial epithelial and monocyte cell lines.
Nath Neerukonda S, Mahadev-Bhat S, Aylward B, Johnson C, Charavaryamath C, Arsenault RJ.
Innate Immun. 2018 Aug;24(6):366-381. doi: 10.1177/1753425918792070. Epub 2018 Aug 9.

NLRP3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter.
Zheng R, Tao L, Jian H, Chang Y, Cheng Y, Feng Y, Zhang H.
Ecotoxicol Environ Saf. 2018 Nov 15;163:612-619. doi: 10.1016/j.ecoenv.2018.07.076. Epub 2018 Aug 6.

Protective Effects of Nintedanib against Polyhexamethylene Guanidine Phosphate-Induced LungFibrosis in Mice.
Kim HY, Kim MS, Kim SH, Joen D, Lee K.
Molecules. 2018 Aug 7;23(8). pii: E1974. doi: 10.3390/molecules23081974.

NLRP3 deficiency exacerbates enterovirus infection in mice.
Wang C, Fung G, Deng H, Jagdeo J, Mohamud Y, Xue YC, Jan E, Hirota JA, Luo H.
FASEB J. 2019 Jan;33(1):942-952. doi: 10.1096/fj.201800301RRR. Epub 2018 Aug 6.

Ozone protects the rat lung from ischemia-reperfusion injury by attenuating NLRP3-mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis.
Wang Z, Zhang A, Meng W, Wang T, Li D, Liu Z, Liu H.
Eur J Pharmacol. 2018 Sep 15;835:82-93. doi: 10.1016/j.ejphar.2018.07.059. Epub 2018 Jul 31.

Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3inflammasome activation.
Jiang Y, Yang W, Gui S.
Immunobiology. 2018 Oct;223(10):555-561. doi: 10.1016/j.imbio.2018.07.001. Epub 2018 Jul 6.

A Pilot Study To Investigate the Immune-Modulatory Effects of Fasting in Steroid-Naive Mild Asthmatics.
Han K, Nguyen A, Traba J, Yao X, Kaler M, Huffstutler RD, Levine SJ, Sack MN.
J Immunol. 2018 Sep 1;201(5):1382-1388. doi: 10.4049/jimmunol.1800585. Epub 2018 Jul 18.

Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD.
Peng Z, Zhang W, Qiao J, He B.
Int Immunopharmacol. 2018 Sep;62:23-28. doi: 10.1016/j.intimp.2018.06.033. Epub 2018 Jun 30.

[Interventional effects of BAY11-7082 on lung inflammatory response at the early stage and acute lung injury of rats with severe burns].
Li HS, Yang XK, Hao ZM, Lei J.
Zhonghua Shao Shang Za Zhi. 2018 Feb 20;34(2):88-95. doi: 10.3760/cma.j.issn.1009-2587.2018.02.006. Chinese.

Interleukin-18 and the NLR family pyrin domain containing-3 inflammasome in adipose tissue are strongly associated with glucometabolic variables in a cohort of middle-aged men.
Åkra S, Aksnes TA, Flaa A, Eggesbø HB, Opstad TB, Njerve IU, Seljeflot I.
Diab Vasc Dis Res. 2018 Sep;15(5):458-464. doi: 10.1177/1479164118785307. Epub 2018 Jul 4.

The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation.
Di A, Xiong S, Ye Z, Malireddi RKS, Kometani S, Zhong M, Mittal M, Hong Z, Kanneganti TD, Rehman J, Malik AB
Immunity. 2018 Jul 17;49(1):56-65.e4. doi: 10.1016/j.immuni.2018.04.032. Epub 2018 Jun 26

Biological mechanisms of non-linear dose-response for respirable mineral fibers.
Cox LAT Jr.
Toxicol Appl Pharmacol. 2018 Dec 15;361:137-144. doi: 10.1016/j.taap.2018.06.016. Epub 2018 Jun 20. Review.

SOCS-1 Suppresses Inflammation Through Inhibition of NALP3 Inflammasome Formation in Smoke Inhalation-Induced Acute Lung Injury.
Zhang L, Xu C, Chen X, Shi Q, Su W, Zhao H.
Inflammation. 2018 Aug;41(4):1557-1567. doi: 10.1007/s10753-018-0802-y.

Electroporation-mediated delivery of FER gene enhances innate immune response and improves survival in a murine model of pneumonia.
Dolgachev V, Panicker S, Balijepalli S, McCandless LK, Yin Y, Swamy S, Suresh MV, Delano MJ, Hemmila MR, Raghavendran K, Machado-Aranda D.
Gene Ther. 2018 Aug;25(5):359-375. doi: 10.1038/s41434-018-0022-y. Epub 2018 Jun 15.

Inflammatory mediators ATP and S100A12 activate the NLRP3 inflammasome to induce MUC5AC production in airway epithelial cells.
Kim K, Kim HJ, Binas B, Kang JH, Chung IY.
Biochem Biophys Res Commun. 2018 Sep 5;503(2):657-664. doi: 10.1016/j.bbrc.2018.06.057. Epub 2018 Jun 15.

NLRP3 inflammasome: A likely target for the treatment of allergic diseases.
Xiao Y, Xu W, Su W.
Clin Exp Allergy. 2018 Sep;48(9):1080-1091. doi: 10.1111/cea.13190. Epub 2018 Jul 3. Review.

NLRP3/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lunginjury induced by cardiopulmonary bypass.
Hou L, Yang Z, Wang Z, Zhang X, Zhao Y, Yang H, Zheng B, Tian W, Wang S, He Z, Wang X.
Lab Invest. 2018 Aug;98(8):1052-1064. doi: 10.1038/s41374-018-0073-0. Epub 2018 Jun 8.

Jinxin oral liquid inhibits human respiratory syncytial virus-induced excessive inflammation associated with blockade of the NLRP3/ASC/Caspase-1 pathway.
Shen C, Zhang Z, Xie T, Xu J, Yan J, Kang A, Dai Q, Wang S, Ji J, Shan J.
Biomed Pharmacother. 2018 Jul;103:1376-1383. doi: 10.1016/j.biopha.2018.04.174. Epub 2018 May 7.

Saturated fatty acids, obesity, and the nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in asthmatic patients.
Wood LG, Li Q, Scott HA, Rutting S, Berthon BS, Gibson PG, Hansbro PM, Williams E, Horvat J, Simpson JL, Young P, Oliver BG, Baines KJ.
J Allergy Clin Immunol. 2019 Jan;143(1):305-315. doi: 10.1016/j.jaci.2018.04.037. Epub 2018 May 30.

Linarin prevents LPS‑induced acute lung injury by suppressing oxidative stress and inflammation via inhibition of TXNIP/NLRP3 and NF‑κB pathways.
Han X, Wu YC, Meng M, Sun QS, Gao SM, Sun H.
Int J Mol Med. 2018 Sep;42(3):1460-1472. doi: 10.3892/ijmm.2018.3710. Epub 2018 May 30.

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18.
Wang J, Sahoo M, Lantier L, Warawa J, Cordero H, Deobald K, Re F.
PLoS Pathog. 2018 May 23;14(5):e1007105. doi: 10.1371/journal.ppat.1007105. eCollection 2018 May.

Pirfenidone ameliorates lipopolysaccharide-induced pulmonary inflammation and fibrosis by blocking NLRP3 inflammasome activation.
Li Y, Li H, Liu S, Pan P, Su X, Tan H, Wu D, Zhang L, Song C, Dai M, Li Q, Mao Z, Long Y, Hu Y, Hu C.
Mol Immunol. 2018 Jul;99:134-144. doi: 10.1016/j.molimm.2018.05.003. Epub 2018 May 26.

Effects and molecular mechanisms of intrauterine infection/inflammation on lung development.
Pan J, Zhan C, Yuan T, Wang W, Shen Y, Sun Y, Wu T, Gu W, Chen L, Yu H.
Respir Res. 2018 May 10;19(1):93. doi: 10.1186/s12931-018-0787-y.

Artesunate Inhibits Renal Ischemia-Reperfusion-Mediated Remote Lung Inflammation Through Attenuating ROS-Induced Activation of NLRP3 Inflammasome.
Liu Z, Qu M, Yu L, Song P, Chang Y.
Inflammation. 2018 Aug;41(4):1546-1556. doi: 10.1007/s10753-018-0801-z.

Mitochondrial Autophagy and NLRP3 Inflammasome in Pulmonary Tissues from Severe Combined Immunodeficient Mice after Cardiac Arrest and Cardiopulmonary Resuscitation.
Lyu JJ, Mehta JL, Li Y, Ye L, Sun SN, Sun HS, Li JC, Zhang DM, Wei J.
Chin Med J (Engl). 2018 May 20;131(10):1174-1184. doi: 10.4103/0366-6999.231519

Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway.
Lu Y, Yu T, Liu J, Gu L.
PLoS One. 2018 Apr 25;13(4):e0196405. doi: 10.1371/journal.pone.0196405. eCollection 2018.

Autoinflammatory disease in the lung.
Scambler T, Holbrook J, Savic S, McDermott MF, Peckham D.
Immunology. 2018 Apr 19. doi: 10.1111/imm.12937. [Epub ahead of print] Review.

Activation of the Absent in Melanoma 2 Inflammasome in Peripheral Blood Mononuclear Cells From Idiopathic Pulmonary Fibrosis Patients Leads to the Release of Pro-Fibrotic Mediators.
Terlizzi M, Molino A, Colarusso C, Donovan C, Imitazione P, Somma P, Aquino RP, Hansbro PM, Pinto A, Sorrentino R.
Front Immunol. 2018 Apr 5;9:670. doi: 10.3389/fimmu.2018.00670. eCollection 2018.

NLRP3 Inflammasome Involves in the Acute Exacerbation of Patients with Chronic Obstructive Pulmonary Disease.
Wang H, Lv C, Wang S, Ying H, Weng Y, Yu W.
Inflammation. 2018 Aug;41(4):1321-1333. doi: 10.1007/s10753-018-0780-0

NLRP3 regulates macrophage M2 polarization through up-regulation of IL-4 in asthma.
Liu Y, Gao X, Miao Y, Wang Y, Wang H, Cheng Z, Wang X, Jing X, Jia L, Dai L, Liu M, An L.
Biochem J. 2018 Jun 21;475(12):1995-2008. doi: 10.1042/BCJ20180086.

Airway epithelial phosphoinositide 3-kinase-δ contributes to the modulation of fungi-induced innate immune response.
Jeong JS, Lee KB, Kim SR, Kim DI, Park HJ, Lee HK, Kim HJ, Cho SH, Kolliputi N, Kim SH, Lee YC.
Thorax. 2018 Aug;73(8):758-768. doi: 10.1136/thoraxjnl-2017-210326. Epub 2018 Apr 5.

The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice.
Robinson KM, Ramanan K, Clay ME, McHugh KJ, Pilewski MJ, Nickolich KL, Corey C, Shiva S, Wang J, Muzumdar R, Alcorn JF.
JCI Insight. 2018 Apr 5;3(7). pii: 97470. doi: 10.1172/jci.insight.97470. eCollection 2018 Apr 5.

Inflammasome-Independent Leukotriene B4 Production Drives Crystalline Silica-Induced Sterile Inflammation.
Hegde B, Bodduluri SR, Satpathy SR, Alghsham RS, Jala VR, Uriarte SM, Chung DH, Lawrenz MB, Haribabu B.
J Immunol. 2018 May 15;200(10):3556-3567. doi: 10.4049/jimmunol.1701504. Epub 2018 Apr 2.

Nebulized lidocaine ameliorates allergic airway inflammation via downregulation of TLR2.
Wang L, Wang M, Li S, Wu H, Shen Q, Zhang S, Fang L, Liu R.
Mol Immunol. 2018 May;97:94-100. doi: 10.1016/j.molimm.2018.03.010. Epub 2018 Mar 30.

Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1α/TNFAIP3 Axis.
Kang Y, Zhang H, Zhao Y, Wang Y, Wang W, He Y, Zhang W, Zhang W, Zhu X, Zhou Y, Zhang L, Ju Z, Shi L.
Cell Rep. 2018 Mar 27;22(13):3493-3506. doi: 10.1016/j.celrep.2018.02.071.

Effect of Soluble Epoxide Hydrolase in Hyperoxic Acute Lung Injury in Mice.
Li PS, Tao W, Yang LQ, Shu YS.
Inflammation. 2018 Jun;41(3):1065-1072. doi: 10.1007/s10753-018-0758-y.

Atractylodin attenuates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3inflammasome and TLR4 pathways.
Tang F, Fan K, Wang K, Bian C.
J Pharmacol Sci. 2018 Apr;136(4):203-211. doi: 10.1016/j.jphs.2017.11.010. Epub 2018 Feb 2.

Involvement of TLR4 and PPAR-α Receptors in Host Response and NLRP3 Inflammasome Activation, Against Pulmonary Infection With Pseudomonas Aeruginosa.
Gugliandolo E, Fusco R, Ginestra G, D’amico R, Bisignano C, Mandalari G, Cuzzocrea S, Di Paola R.
Shock. 2019 Feb;51(2):221-227. doi: 10.1097/SHK.0000000000001137.

ATP/P2X7-NLRP3 axis of dendritic cells participates in the regulation of airway inflammation and hyper-responsiveness in asthma by mediating HMGB1 expression and secretion.
Li R, Wang J, Li R, Zhu F, Xu W, Zha G, He G, Cao H, Wang Y, Yang J.
Exp Cell Res. 2018 May 1;366(1):1-15. doi: 10.1016/j.yexcr.2018.03.002. Epub 2018 Mar 12.

Effects on IL-1β signaling activation induced by water and organic extracts of fine particulate matter (PM2.5) in vitro.
Xu F, Qiu X, Hu X, Shang Y, Pardo M, Fang Y, Wang J, Rudich Y, Zhu T.
Environ Pollut. 2018 Jun;237:592-600. doi: 10.1016/j.envpol.2018.02.086. Epub 2018 Mar 15.

Oleanolic acid acetate attenuates polyhexamethylene guanidine phosphate-induced pulmonary inflammation and fibrosis in mice.
Kim MS, Han JY, Kim SH, Jeon D, Kim HY, Lee SW, Rho MC, Lee K.
Respir Physiol Neurobiol. 2018 Jun;252-253:1-9. doi: 10.1016/j.resp.2018.03.001. Epub 2018 Mar 2.

Development of tissue inflammation accompanied by NLRP3 inflammasome activation in rabbits infected with Treponema pallidum strain Nichols.
Lin LR, Xiao Y, Liu W, Chen YY, Zhu XZ, Gao ZX, Gao K, Tong ML, Zhang HL, Li SL, Lin HL, Li WD, Liang XM, Lin Y, Liu LL, Yang TC.
BMC Infect Dis. 2018 Mar 1;18(1):101. doi: 10.1186/s12879-018-2993-0.

Autophagy Attenuates Angiotensin II-Induced Pulmonary Fibrosis by Inhibiting Redox Imbalance-Mediated NOD-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation.
Meng Y, Pan M, Zheng B, Chen Y, Li W, Yang Q, Zheng Z, Sun N, Zhang Y, Li X.
Antioxid Redox Signal. 2019 Feb 1;30(4):520-541. doi: 10.1089/ars.2017.7261. Epub 2018 May 7.

RAGE-induced changes in the proteome of alveolar epithelial cells.
Downs CA, Johnson NM, Tsaprailis G, Helms MN.
J Proteomics. 2018 Apr 15;177:11-20. doi: 10.1016/j.jprot.2018.02.010. Epub 2018 Feb 12.

Inflammatory Monocytes Drive Influenza A Virus-Mediated Lung Injury in Juvenile Mice.
Coates BM, Staricha KL, Koch CM, Cheng Y, Shumaker DK, Budinger GRS, Perlman H, Misharin AV, Ridge KM.
J Immunol. 2018 Apr 1;200(7):2391-2404. doi: 10.4049/jimmunol.1701543. Epub 2018 Feb 14.

Macrophage Recognition of Crystals and Nanoparticles.
Nakayama M.
Front Immunol. 2018 Jan 29;9:103. doi: 10.3389/fimmu.2018.00103. eCollection 2018. Review.

The NALP3 inflammasome is required for collagen synthesis via the NF‑κB pathway.
Kuang J, Xie M, Wei X.
Int J Mol Med. 2018 Apr;41(4):2279-2287. doi: 10.3892/ijmm.2018.3404. Epub 2018 Jan 18.

Platelets at the crossroads of thrombosis, inflammation and haemolysis.
Vogel S, Thein SL.
Br J Haematol. 2018 Mar;180(5):761-767. doi: 10.1111/bjh.15117. Epub 2018 Jan 30.

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D’Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA.
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073/pnas.1716095115. Epub 2018 Jan 29.

Galectin-3 Enhances Avian H5N1 Influenza A Virus-Induced Pulmonary Inflammation by Promoting NLRP3 Inflammasome Activation.
Chen YJ, Wang SF, Weng IC, Hong MH, Lo TH, Jan JT, Hsu LC, Chen HY, Liu FT.
Am J Pathol. 2018 Apr;188(4):1031-1042. doi: 10.1016/j.ajpath.2017.12.014. Epub 2018 Jan 31.

Yupingfeng San Inhibits NLRP3 Inflammasome to Attenuate the Inflammatory Response in Asthma Mice.
Liu X, Shen J, Fan D, Qiu X, Guo Q, Zheng K, Luo H, Shu J, Lu C, Zhang G, Lu A, Ma C, He X.
Front Pharmacol. 2017 Dec 22;8:944. doi: 10.3389/fphar.2017.00944. eCollection 2017.

Gene mutations and clinical phenotypes in 15 Chinese children with cryopyrin-associated periodic syndrome (CAPS).
Li C, Tan X, Zhang J, Li S, Mo W, Han T, Kuang W, Zhou Y, Deng J.
Sci China Life Sci. 2017 Dec;60(12):1436-1444. doi: 10.1007/s11427-017-9246-4. Epub 2017 Dec 2.

Resveratrol alleviates Staphylococcus aureus pneumonia by inhibition of the NLRP3 inflammasome.
Wu S, Huang J.
Exp Ther Med. 2017 Dec;14(6):6099-6104. doi: 10.3892/etm.2017.5337. Epub 2017 Oct 18.

NLRP3 Controls the Development of Gastrointestinal CD11b+ Dendritic Cells in the Steady State and during Chronic Bacterial Infection.
Arnold IC, Zhang X, Urban S, Artola-Borán M, Manz MG, Ottemann KM, Müller A.
Cell Rep. 2017 Dec 26;21(13):3860-3872. doi: 10.1016/j.celrep.2017.12.015.

Nanoparticle-induced inflammation can increase tumor malignancy.
Manshian BB, Poelmans J, Saini S, Pokhrel S, Grez JJ, Himmelreich U, Mädler L, Soenen SJ.
Acta Biomater. 2018 Mar 1;68:99-112. doi: 10.1016/j.actbio.2017.12.020. Epub 2017 Dec 20.

NLRP3 inflammasome inhibition attenuates silica-induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells.
Li X, Yan X, Wang Y, Wang J, Zhou F, Wang H, Xie W, Kong H.
Exp Cell Res. 2018 Jan 15;362(2):489-497. doi: 10.1016/j.yexcr.2017.12.013. Epub 2017 Dec 16.

Protective effect of baicalin against severe burn‑induced remote acute lung injury in rats.
Bai C, Li T, Sun Q, Xin Q, Xu T, Yu J, Wang Y, Wei L.
Mol Med Rep. 2018 Feb;17(2):2689-2694. doi: 10.3892/mmr.2017.8120. Epub 2017 Nov 20.

Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection.
Cho SJ, Plataki M, Mitzel D, Lowry G, Rooney K, Stout-Delgado H.
Exp Gerontol. 2018 May;105:40-46. doi: 10.1016/j.exger.2017.11.010. Epub 2017 Dec 7.

Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein.
Shil NK, Pokharel SM, Banerjee AK, Hoffman M, Bose S.
J Virol. 2018 Jan 30;92(4). pii: e01776-17. doi: 10.1128/JVI.01776-17. Print 2018 Feb 15.

The Human-Associated Archaeon Methanosphaera stadtmanae Is Recognized through Its RNA and Induces TLR8-Dependent NLRP3 Inflammasome Activation.
Vierbuchen T, Bang C, Rosigkeit H, Schmitz RA, Heine H.
Front Immunol. 2017 Nov 13;8:1535. doi: 10.3389/fimmu.2017.01535. eCollection 2017.

Antimycobacterial and Anti-inflammatory Mechanisms of Baicalin via Induced Autophagy in Macrophages Infected with Mycobacterium tuberculosis.
Zhang Q, Sun J, Wang Y, He W, Wang L, Zheng Y, Wu J, Zhang Y, Jiang X.
Front Microbiol. 2017 Nov 2;8:2142. doi: 10.3389/fmicb.2017.02142. eCollection 201

Vitamin D3 levels and NLRP3 expression in murine models of obese asthma: association with asthma outcomes.
Zhang JH, Chen YP, Yang X, Li CQ.
Braz J Med Biol Res. 2017 Nov 13;51(1):e6841. doi: 10.1590/1414-431X20176841.

Polymorphisms in inflammasome genes and risk of asthma in Brazilian children.
Leal VNC, Genov IR, Mallozi MC, Solé D, Pontillo A.
Mol Immunol. 2018 Jan;93:64-67. doi: 10.1016/j.molimm.2017.11.006. Epub 2017 Nov 15.

Cancer cells induce interleukin-22 production from memory CD4+ T cells via interleukin-1 to promote tumor growth.
Voigt C, May P, Gottschlich A, Markota A, Wenk D, Gerlach I, Voigt S, Stathopoulos GT, Arendt KAM, Heise C, Rataj F, Janssen KP, Königshoff M, Winter H, Himsl I, Thasler WE, Schnurr M, Rothenfußer S, Endres S, Kobold S.
Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12994-12999. doi: 10.1073/pnas.1705165114. Epub 2017 Nov 17.

Ly6G+ neutrophil-derived miR-223 inhibits the NLRP3 inflammasome in mitochondrial DAMP-induced acute lung injury.
Feng Z, Qi S, Zhang Y, Qi Z, Yan L, Zhou J, He F, Li Q, Yang Y, Chen Q, Xiao S, Li Q, Chen Y, Zhang Y.
Cell Death Dis. 2017 Nov 16;8(11):e3170. doi: 10.1038/cddis.2017.549.

Role of the inflammasome in chronic obstructive pulmonary disease (COPD).
Colarusso C, Terlizzi M, Molino A, Pinto A, Sorrentino R.
Oncotarget. 2017 May 13;8(47):81813-81824. doi: 10.18632/oncotarget.17850. eCollection 2017 Oct 10.

Mitochondria Targeted Peptide Attenuates Mitochondrial Dysfunction, Controls Inflammation and Protects Against Spinal Cord Injury-Induced Lung Injury.
Zhu LL, Li MQ, He F, Zhou SB, Jiang W.
Cell Physiol Biochem. 2017;44(1):388-400. doi: 10.1159/000484919. Epub 2017 Nov 13.

Polymeric Nanoparticles Induce NLRP3 Inflammasome Activation and Promote Breast Cancer Metastasis.
Hu Q, Zhao F, Guo F, Wang C, Fu Z.
Macromol Biosci. 2017 Dec;17(12). doi: 10.1002/mabi.201700273. Epub 2017 Nov 13.

[NLRP3 inflammasome induces pyroptosis in lung tissues of radiation-induced lung injury in mice].
Han R, Wu D, Deng S, Liu T, Zhang T, Xu Y.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Sep;33(9):1206-1211. Chinese.

NLRP3 Inflammasome Activation Contributes to Mechanical Stretch-Induced Endothelial-Mesenchymal Transition and Pulmonary Fibrosis.
Lv Z, Wang Y, Liu YJ, Mao YF, Dong WW, Ding ZN, Meng GX, Jiang L, Zhu XY.
Crit Care Med. 2018 Jan;46(1):e49-e58. doi: 10.1097/CCM.0000000000002799.

Mir-21 Mediates the Inhibitory Effect of Ang (1-7) on AngII-induced NLRP3 Inflammasome Activation by Targeting Spry1 in lung fibroblasts.
Sun NN, Yu CH, Pan MX, Zhang Y, Zheng BJ, Yang QJ, Zheng ZM, Meng Y.
Sci Rep. 2017 Oct 30;7(1):14369. doi: 10.1038/s41598-017-13305-3.

[Significance of the NLRP3 inflammasome expression in rats with acute lung injury induced by phosgene].
He DK, Shao YR, Shen J, Zhang L, Zhang J, Zhang F.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2017 Jul 20;35(7):491-496. doi: 10.3760/cma.j.issn.1001-9391.2017.07.004. Chinese.

Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection.
Peiró T, Patel DF, Akthar S, Gregory LG, Pyle CJ, Harker JA, Birrell MA, Lloyd CM, Snelgrove RJ.
Thorax. 2018 Jun;73(6):546-556. doi: 10.1136/thoraxjnl-2017-210010. Epub 2017 Oct 27.

NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection.
Segovia JA, Chang TH, Winter VT, Coalson JJ, Cagle MP, Pandranki L, Bose S, Baseman JB, Kannan TR.
Infect Immun. 2017 Dec 19;86(1). pii: e00548-17. doi: 10.1128/IAI.00548-17. Print 2018 Jan

Protective effect of cinnamic acid in endotoxin-poisoned mice.
Xu F, Wang F, Wen T, Sang W, He X, Li L, Zeng N.
Phytother Res. 2017 Dec;31(12):1946-1953. doi: 10.1002/ptr.5944. Epub 2017 Oct 11.

Saikosaponin a Ameliorates LPS-Induced Acute Lung Injury in Mice.
Du ZA, Sun MN, Hu ZS.
Inflammation. 2018 Feb;41(1):193-198. doi: 10.1007/s10753-017-0677-3.

ASC and NLRP3 impair host defense during lethal pneumonia caused by serotype 3 Streptococcus pneumoniae in mice.
van Lieshout MHP, de Vos AF, Dessing MC, de Porto APNA, de Boer OJ, de Beer R, Terpstra S, Florquin S, Van’t Veer C, van der Poll T.
Eur J Immunol. 2018 Jan;48(1):66-79. doi: 10.1002/eji.201646554. Epub 2017 Nov 3.

Length, but Not Reactive Edges, of Cup-stack MWCNT Is Responsible for Toxicity and Acute LungInflammation.
Hamilton RF Jr, Tsuruoka S, Wu N, Wolfarth M, Porter DW, Bunderson-Schelvan M, Holian A.
Toxicol Pathol. 2018 Jan;46(1):62-74. doi: 10.1177/0192623317732303. Epub 2017 Sep 25.

Caspase-11 deficiency impairs neutrophil recruitment and bacterial clearance in the early stage of pulmonary Klebsiella pneumoniae infection.
Wang J, Shao Y, Wang W, Li S, Xin N, Xie F, Zhao C.
Int J Med Microbiol. 2017 Dec;307(8):490-496. doi: 10.1016/j.ijmm.2017.09.012. Epub 2017 Sep 12.

Calcitonin gene-related peptide exerts anti-inflammatory property through regulating murine macrophages polarization in vitro.
Duan JX, Zhou Y, Zhou AY, Guan XX, Liu T, Yang HH, Xie H, Chen P.
Mol Immunol. 2017 Nov;91:105-113. doi: 10.1016/j.molimm.2017.08.020. Epub 2017 Sep 8.

Dexmedetomidine Alleviates Hyperoxia-Induced Acute Lung Injury via Inhibiting NLRP3Inflammasome Activation.
Zhang Q, Wu D, Yang Y, Liu T, Liu H.
Cell Physiol Biochem. 2017;42(5):1907-1919. doi: 10.1159/000479609. Epub 2017 Aug 3.

Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model: a translational study.
Spengler D, Winoto-Morbach S, Kupsch S, Vock C, Blöchle K, Frank S, Rintz N, Diekötter M, Janga H, Weckmann M, Fuchs S, Schromm AB, Fehrenbach H, Schütze S, Krause MF.
Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L32-L53. doi: 10.1152/ajplung.00128.2017. Epub 2017 Aug 31.

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial.
Ridker PM, MacFadyen JG, Thuren T, Everett BM, Libby P, Glynn RJ; CANTOS Trial Group.
Lancet. 2017 Oct 21;390(10105):1833-1842. doi: 10.1016/S0140-6736(17)32247-X. Epub 2017 Aug 27.

Alcohol abuse is associated with enhanced pulmonary and systemic xanthine oxidoreductase activity.
Fini MA, Gaydos J, McNally A, Karoor V, Burnham EL.
Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1047-L1057. doi: 10.1152/ajplung.00570.2016. Epub 2017 Aug 24.

The activation of NLRP3-inflammsome by stimulation of diesel exhaust particles in lung tissues from emphysema model and RAW 264.7 cell line.
Uh ST, Koo SM, Kim Y, Kim K, Park S, Jang AS, Kim D, Kim YH, Park CS.

Digitoflavone (DG) attenuates LPS-induced acute lung injury through reducing oxidative stress and inflammatory response dependent on the suppression of TXNIP/NLRP3 and NF-κB.
Meng M.
Biomed Pharmacother. 2017 Oct;94:712-725. doi: 10.1016/j.biopha.2017.07.001. Epub 2017 Aug

Inhibition of NLRP3 inflammasome: a new protective mechanism of cinnamaldehyde in endotoxin poisoning of mice.
Xu F, Wang F, Wen T, Sang W, Wang D, Zeng N.
Immunopharmacol Immunotoxicol. 2017 Oct;39(5):296-304. doi: 10.1080/08923973.2017.1355377. Epub 2017 Aug 1.

[The Effect of Sodium Ferulate in Experimental Pulmonary Fibrosis via NALP3 Inflammasome].
Kuang J, Wei XL, Xie M.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 Jul;48(4):503-508. Chinese.

A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3inflammasome by neutralizing LPS and ATP.
Li LH, Ju TC, Hsieh CY, Dong WC, Chen WT, Hua KF, Chen WJ.
PLoS One. 2017 Jul 27;12(7):e0182057. doi: 10.1371/journal.pone.0182057. eCollection 2017.

Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection.
Coates BM, Staricha KL, Ravindran N, Koch CM, Cheng Y, Davis JM, Shumaker DK, Ridge KM.
Front Immunol. 2017 Jul 10;8:782. doi: 10.3389/fimmu.2017.00782. eCollection 2017.

Macrolides protect against Pseudomonas aeruginosa infection via inhibition of inflammasomes.
Fan LC, Lin JL, Yang JW, Mao B, Lu HW, Ge BX, Choi AMK, Xu JF.
Am J Physiol Lung Cell Mol Physiol. 2017 Oct 1;313(4):L677-L686. doi: 10.1152/ajplung.00123.2017. Epub 2017 Jul 6.

MD-2 regulates LPS-induced NLRP3 inflammasome activation and IL-1beta secretion by a MyD88/NF-κB-dependent pathway in alveolar macrophages cell line.
Luo M, Hu L, Li D, Wang Y, He Y, Zhu L, Ren W.
Mol Immunol. 2017 Oct;90:1-10. doi: 10.1016/j.molimm.2017.06.035. Epub 2017 Jun 24.

Role of P2X7R in the development and progression of pulmonary hypertension.
Yin J, You S, Liu H, Chen L, Zhang C, Hu H, Xue M, Cheng W, Wang Y, Li X, Shi Y, Li N, Yan S, Li X.
Respir Res. 2017 Jun 24;18(1):127. doi: 10.1186/s12931-017-0603-0.

NLRP3 inflammasome pathway has a critical role in the host immunity against clinically relevant Acinetobacter baumannii pulmonary infection.
Dikshit N, Kale SD, Khameneh HJ, Balamuralidhar V, Tang CY, Kumar P, Lim TP, Tan TT, Kwa AL, Mortellaro A, Sukumaran B.
Mucosal Immunol. 2018 Jan;11(1):257-272. doi: 10.1038/mi.2017.50. Epub 2017 Jun 14.

MiR-20b inhibits mycobacterium tuberculosis induced inflammation in the lung of mice through targeting NLRP3.
Lou J, Wang Y, Zhang Z, Qiu W.
Exp Cell Res. 2017 Sep 15;358(2):120-128. doi: 10.1016/j.yexcr.2017.06.007. Epub 2017 Jun 10.

[Sodium Ferulate Attenuates Oxidative Stressvia Suppressing NALP3 Inflammasome and ERK Signal Pathway].
Wei XL, Xie M, He GY.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2016 Sep;47(5):655-659. Chinese.

NLRP3 participates in the regulation of EMT in bleomycin-induced pulmonary fibrosis.
Tian R, Zhu Y, Yao J, Meng X, Wang J, Xie H, Wang R.
Exp Cell Res. 2017 Aug 15;357(2):328-334. doi: 10.1016/j.yexcr.2017.05.028. Epub 2017 Jun 4.

Pyrin-only protein 2 limits inflammation but improves protection against bacteria
Periasamy S, Porter KA, Atianand MK, T Le H, Earley S, Duffy EB, Haller MC, Chin H, Harton JA.
Nat Commun. 2017 Jun 5;8:15564. doi: 10.1038/ncomms15564.

IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult.
Xiao H, Li H, Wang JJ, Zhang JS, Shen J, An XB, Zhang CC, Wu JM, Song Y, Wang XY, Yu HY, Deng XN, Li ZJ, Xu M, Lu ZZ, Du J, Gao W, Zhang AH, Feng Y, Zhang YY.
Eur Heart J. 2018 Jan 1;39(1):60-69. doi: 10.1093/eurheartj/ehx261.

Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.
Rossios C, Pavlidis S, Hoda U, Kuo CH, Wiegman C, Russell K, Sun K, Loza MJ, Baribaud F, Durham AL, Ojo O, Lutter R, Rowe A, Bansal A, Auffray C, Sousa A, Corfield J, Djukanovic R, Guo Y, Sterk PJ, Chung KF, Adcock IM; Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes (U-BIOPRED) Consortia Project Team.
J Allergy Clin Immunol. 2018 Feb;141(2):560-570. doi: 10.1016/j.jaci.2017.02.045. Epub 2017 May 18.

Salidroside Attenuates Ventilation Induced Lung Injury via SIRT1-Dependent Inhibition of NLRP3Inflammasome.
Wang Y, Xu CF, Liu YJ, Mao YF, Lv Z, Li SY, Zhu XY, Jiang L.
Cell Physiol Biochem. 2017;42(1):34-43. doi: 10.1159/000477112. Epub 2017 May 10.

Therapeutic effects of silibinin on LPS-induced acute lung injury by inhibiting NLRP3 and NF-κB signaling pathways.
Tian L, Li W, Wang T.
Microb Pathog. 2017 Jul;108:104-108. doi: 10.1016/j.micpath.2017.05.011. Epub 2017 May 5.

Human Plasma Thioredoxin-80 Increases With Age and in ApoE-/- Mice Induces Inflammation, Angiogenesis, and Atherosclerosis.
Couchie D, Vaisman B, Abderrazak A, Mahmood DFD, Hamza MM, Canesi F, Diderot V, El Hadri K, Nègre-Salvayre A, Le Page A, Fulop T, Remaley AT, Rouis M.
Circulation. 2017 Aug 1;136(5):464-475. doi: 10.1161/CIRCULATIONAHA.117.027612. Epub 2017 May 4.

Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3inflammasome.
Hoyt LR, Randall MJ, Ather JL, DePuccio DP, Landry CC, Qian X, Janssen-Heininger YM, van der Vliet A, Dixon AE, Amiel E, Poynter ME.
Redox Biol. 2017 Aug;12:883-896. doi: 10.1016/j.redox.2017.04.020. Epub 2017 Apr 25.

Inhibition of inflammasome activation improves lung acute injury induced by carrageenan in a mouse model of pleurisy.
Fusco R, Gugliandolo E, Biundo F, Campolo M, Di Paola R, Cuzzocrea S.
FASEB J. 2017 Aug;31(8):3497-3511. doi: 10.1096/fj.201601349R. Epub 2017 May 1.

LFG-500, a novel synthetic flavonoid, suppresses epithelial-mesenchymal transition in human lungadenocarcinoma cells by inhibiting NLRP3 in inflammatory microenvironment.
Yang D, Cao X, Wang F, Jiang H, Feng D, Guo H, Du L, Jin Y, Chen Y, Yin X, Li C.
Cancer Lett. 2017 Aug 1;400:137-148. doi: 10.1016/j.canlet.2017.04.035. Epub 2017 Apr 29.

Colchicine Improves Survival, Left Ventricular Remodeling, and Chronic Cardiac Function After Acute Myocardial Infarction.
Fujisue K, Sugamura K, Kurokawa H, Matsubara J, Ishii M, Izumiya Y, Kaikita K, Sugiyama S.
Circ J. 2017 Jul 25;81(8):1174-1182. doi: 10.1253/circj.CJ-16-0949. Epub 2017 Apr 18.

NLRP3 inflammasome induced liver graft injury through activation of telomere-independent RAP1/KC axis.
Liu H, Lo CM, Yeung OWH, Li CX, Liu XB, Qi X, Ng KTP, Liu J, Ma YY, Lam YF, Lian Q, Chan SC, Man K.
J Pathol. 2017 Jul;242(3):284-296. doi: 10.1002/path.4901. Epub 2017 May 15.

Target practice in severe asthma.
Christenson SA.
Sci Transl Med. 2017 Mar 29;9(383). pii: eaan0769. doi: 10.1126/scitranslmed.aan0769.

Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3activation.
Zhang B, Wang B, Cao S, Wang Y, Wu D.
Int J Mol Med. 2017 May;39(5):1111-1118. doi: 10.3892/ijmm.2017.2935. Epub 2017 Mar 27.

Follistatin like-1 aggravates silica-induced mouse lung injury.
Fang Y, Zhang S, Li X, Jiang F, Ye Q, Ning W.
Sci Rep. 2017 Mar 24;7(1):399. doi: 10.1038/s41598-017-00478-0.

Asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (BLM) via suppressing pro-fibrotic and inflammatory signaling pathways.
Dong SH, Liu YW, Wei F, Tan HZ, Han ZD.
Biomed Pharmacother. 2017 May;89:1297-1309. doi: 10.1016/j.biopha.2017.03.005. Epub 2017 Mar 17.

[Mechanism of angiotensin-converting enzyme 2 overexpression improving collagen synthesis in lung].
Yang QJ, Zheng BB, Sun NN, Pan MX, Zheng ZM, Meng Y.
Zhonghua Yi Xue Za Zhi. 2017 Mar 14;97(10):770-776. doi: 10.3760/cma.j.issn.0376-2491.2017.10.011. Chinese.

Protective Effect of Amygdalin on LPS-Induced Acute Lung Injury by Inhibiting NF-κB and NLRP3Signaling Pathways.
Zhang A, Pan W, Lv J, Wu H.
Inflammation. 2017 Jun;40(3):745-751. doi: 10.1007/s10753-017-0518-4.

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis.
Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X.
Redox Biol. 2017 Aug;12:311-324. doi: 10.1016/j.redox.2017.03.001. Epub 2017 Mar 2.

The acute airway inflammation induced by PM2.5 exposure and the treatment of essential oils in Balb/c mice.
Wang H, Song L, Ju W, Wang X, Dong L, Zhang Y, Ya P, Yang C, Li F.
Sci Rep. 2017 Mar 9;7:44256. doi: 10.1038/srep44256.

Nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases.
Hodge S, Tran HB, Hamon R, Roscioli E, Hodge G, Jersmann H, Ween M, Reynolds PN, Yeung A, Treiberg J, Wilbert S.
Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L678-L687. doi: 10.1152/ajplung.00518.2016. Epub 2017 Mar 3.

Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.
Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, Hirota JA, Wood LG, Simpson JL, Knight DA, Wark PA, Gibson PG, O’Neill LAJ, Cooper MA, Horvat JC, Hansbro PM.
Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297. doi: 10.1164/rccm.201609-1830OC.

Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma.
Sebag SC, Koval OM, Paschke JD, Winters CJ, Jaffer OA, Dworski R, Sutterwala FS, Anderson ME, Grumbach IM.
JCI Insight. 2017 Feb 9;2(3):e88297. doi: 10.1172/jci.insight.88297.

The protective effect of dopamine on ventilator-induced lung injury via the inhibition of NLRP3inflammasome.
Yang X, Sun X, Chen H, Xi G, Hou Y, Wu J, Liu D, Wang H, Hou Y, Yu J.
Int Immunopharmacol. 2017 Apr;45:68-73. doi: 10.1016/j.intimp.2017.02.002. Epub 2017 Feb 8.

Inflammasomes in the lung.
Pinkerton JW, Kim RY, Robertson AAB, Hirota JA, Wood LG, Knight DA, Cooper MA, O’Neill LAJ, Horvat JC, Hansbro PM.
Mol Immunol. 2017 Jun;86:44-55. doi: 10.1016/j.molimm.2017.01.014. Epub 2017 Jan 24. Review.

Phagolysosome acidification is required for silica and engineered nanoparticle-induced lysosome membrane permeabilization and resultant NLRP3 inflammasome activity.
Jessop F, Hamilton RF Jr, Rhoderick JF, Fletcher P, Holian A.
Toxicol Appl Pharmacol. 2017 Mar 1;318:58-68. doi: 10.1016/j.taap.2017.01.012. Epub 2017 Jan 24.

Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections.
Hassane M, Demon D, Soulard D, Fontaine J, Keller LE, Patin EC, Porte R, Prinz I, Ryffel B, Kadioglu A, Veening JW, Sirard JC, Faveeuw C, Lamkanfi M, Trottein F, Paget C.
Mucosal Immunol. 2017 Jul;10(4):1056-1068. doi: 10.1038/mi.2016.113. Epub 2017 Jan 4.

NLRP3 inflammasome mediates interleukin-1β production in immune cells in response to Acinetobacter baumannii and contributes to pulmonary inflammation in mice.
Kang MJ, Jo SG, Kim DJ, Park JH.
Immunology. 2017 Apr;150(4):495-505. doi: 10.1111/imm.12704. Epub 2017 Jan 30.

Deletion of Nlrp3 Augments Survival during Polymicrobial Sepsis by Decreasing Autophagy and Enhancing Phagocytosis.
Jin L, Batra S, Jeyaseelan S.
J Immunol. 2017 Feb 1;198(3):1253-1262. doi: 10.4049/jimmunol.1601745. Epub 2016 Dec 28.

Blocking triggering receptor expressed on myeloid cells-1 attenuates lipopolysaccharide-induced acute lung injury via inhibiting NLRP3 inflammasome activation.
Liu T, Zhou Y, Li P, Duan JX, Liu YP, Sun GY, Wan L, Dong L, Fang X, Jiang JX, Guan CX.
Sci Rep. 2016 Dec 22;6:39473. doi: 10.1038/srep39473.

The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome.
Traba J, Sack MN.
Cell Mol Life Sci. 2017 May;74(10):1777-1791. doi: 10.1007/s00018-016-2431-7. Epub 2016 Dec 10. Review.

Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia.
Periasamy S, Le HT, Duffy EB, Chin H, Harton JA.
PLoS Pathog. 2016 Dec 7;12(12):e1006059. doi: 10.1371/journal.ppat.1006059. eCollection 2016 Dec.

PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome.
Pinar A, Dowling JK, Bitto NJ, Robertson AA, Latz E, Stewart CR, Drummond GR, Cooper MA, McAuley JL, Tate MD, Mansell A.
J Biol Chem. 2017 Jan 20;292(3):826-836. doi: 10.1074/jbc.M116.756379. Epub 2016 Dec 2.

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.
Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E.
PLoS Pathog. 2016 Dec 2;12(12):e1006035. doi: 10.1371/journal.ppat.1006035. eCollection 2016 Dec.

Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1.
Oikonomou V, Moretti S, Renga G, Galosi C, Borghi M, Pariano M, Puccetti M, Palmerini CA, Amico L, Carotti A, Prezioso L, Spolzino A, Finocchi A, Rossi P, Velardi A, Aversa F, Napolioni V, Romani L.
Cell Host Microbe. 2016 Dec 14;20(6):744-757. doi: 10.1016/j.chom.2016.10.012. Epub 2016 Nov 23.

Purinergic receptors: new targets for the treatment of gout and fibrosis.
Gicquel T, Le Daré B, Boichot E, Lagente V.
Fundam Clin Pharmacol. 2017 Apr;31(2):136-146. doi: 10.1111/fcp.12256. Epub 2016 Dec 30. Review.

17-oxo-DHA displays additive anti-inflammatory effects with fluticasone propionate and inhibits the NLRP3 inflammasome.
Cipollina C, Di Vincenzo S, Siena L, Di Sano C, Gjomarkaj M, Pace E.
Sci Rep. 2016 Nov 24;6:37625. doi: 10.1038/srep37625.

P2rx4 deficiency in mice alleviates allergen-induced airway inflammation.
Zech A, Wiesler B, Ayata CK, Schlaich T, Dürk T, Hoßfeld M, Ehrat N, Cicko S, Idzko M.
Oncotarget. 2016 Dec 6;7(49):80288-80297. doi: 10.18632/oncotarget.13375.

Dopamine D1 receptor agonist A-68930 inhibits NLRP3 inflammasome activation and protects rats from spinal cord injury-induced acute lung injury.
Jiang W, Li M, He F, Bian Z, Liu J, He Q, Wang X, Sun T, Zhu L.
Spinal Cord. 2016 Nov;54(11):951-956. doi: 10.1038/sc.2016.52. Epub 2016 Apr 12.

Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation.
Peng S, Gao J, Liu W, Jiang C, Yang X, Sun Y, Guo W, Xu Q.
Oncotarget. 2016 Dec 6;7(49):80262-80274. doi: 10.18632/oncotarget.12918.

Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice.
Zhou F, Zhang Y, Chen J, Hu X, Xu Y.
Eur J Pharmacol. 2016 Nov 15;791:735-740. doi: 10.1016/j.ejphar.2016.10.016. Epub 2016 Oct 15.

Targeting inflammasome/IL-1 pathways for cancer immunotherapy.
Guo B, Fu S, Zhang J, Liu B, Li Z.
Sci Rep. 2016 Oct 27;6:36107. doi: 10.1038/srep36107.

Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1β/IL-1R1/MyD88/NF-κB pathway.
Song C, He L, Zhang J, Ma H, Yuan X, Hu G, Tao L, Zhang J, Meng J.
J Cell Mol Med. 2016 Nov;20(11):2064-2077. doi: 10.1111/jcmm.12898. Epub 2016 Jun 16.

The inflammasome pathway in stable COPD and acute exacerbations.
Faner R, Sobradillo P, Noguera A, Gomez C, Cruz T, López-Giraldo A, Ballester E, Soler N, Arostegui JI, Pelegrín P, Rodriguez-Roisin R, Yagüe J, Cosio BG, Juan M, Agustí A.
ERJ Open Res. 2016 Jul 11;2(3). pii: 00002-2016. eCollection 2016 Jul.

Hero turned villain: NLRP3 inflammasome-induced inflammation during influenza A virus infection.
Ong JD, Mansell A, Tate MD.
J Leukoc Biol. 2017 Apr;101(4):863-874. doi: 10.1189/jlb.4MR0616-288R. Epub 2016 Oct 5. Review.

Increased neutrophil expression of pattern recognition receptors during COPD exacerbations.
Pouwels SD, van Geffen WH, Jonker MR, Kerstjens HA, Nawijn MC, Heijink IH.
Respirology. 2017 Feb;22(2):401-404. doi: 10.1111/resp.12912. Epub 2016 Sep 27.

The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases.
Sayan M, Mossman BT.
Part Fibre Toxicol. 2016 Sep 20;13(1):51. doi: 10.1186/s12989-016-0162-4. Review.

Resveratrol ameliorates LPS-induced acute lung injury via NLRP3 inflammasome modulation.
Jiang L, Zhang L, Kang K, Fei D, Gong R, Cao Y, Pan S, Zhao M, Zhao M.
Pharmacother. 2016 Dec;84:130-138. doi: 10.1016/j.biopha.2016.09.020. Epub 2016 Sep 16.

Therapeutic effect of methyl salicylate 2-O-β-d-lactoside on LPS-induced acute lung injury by inhibiting TAK1/NF-kappaB phosphorylation and NLRP3 expression.
Yang S, Yu Z, Yuan T, Wang L, Wang X, Yang H, Sun L, Wang Y, Du G.
Int Immunopharmacol. 2016 Nov;40:219-228. doi: 10.1016/j.intimp.2016.08.041. Epub 2016 Sep 9.

Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis: role in pulmonary inflammation following LPS.
Yang J, Zhao Y, Zhang P, Li Y, Yang Y, Yang Y, Zhu J, Song X, Jiang G, Fan J.
Cell Death Dis. 2016 Sep 8;7(9):e2363. doi: 10.1038/cddis.2016.274.

Protective Effects of Asiatic Acid Against Spinal Cord Injury-Induced Acute Lung Injury in Rats.
Jiang W, Li M, He F, Yao W, Bian Z, Wang X, Zhu L.
Inflammation. 2016 Dec;39(6):1853-1861.

Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure.
Jessop F, Hamilton RF, Rhoderick JF, Shaw PK, Holian A.
Toxicol Appl Pharmacol. 2016 Oct 15;309:101-10. doi: 10.1016/j.taap.2016.08.029. Epub 2016 Sep 1.

Neutrophil pyroptosis mediates pathology of P. aeruginosa lung infection in the absence of the NADPH oxidase NOX2.
Ryu JC, Kim MJ, Kwon Y, Oh JH, Yoon SS, Shin SJ, Yoon JH, Ryu JH.
Mucosal Immunol. 2017 May;10(3):757-774. doi: 10.1038/mi.2016.73. Epub 2016 Aug 24.

Original Rearch: Evaluation of pulmonary response to inhaled tungsten (IV) oxide nanoparticles in golden Syrian hamsters.
Prajapati MV, Adebolu OO, Morrow BM, Cerreta JM.
Exp Biol Med (Maywood). 2017 Jan;242(1):29-44. Epub 2016 Aug 17.

IL-1α and IL-1β-producing macrophages populate lung tumor lesions in mice.
Terlizzi M, Colarusso C, Popolo A, Pinto A, Sorrentino R.
Oncotarget. 2016 Sep 6;7(36):58181-58192. doi: 10.18632/oncotarget.11276.

TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism.
He X, Qian Y, Li Z, Fan EK, Li Y, Wu L, Billiar TR, Wilson MA, Shi X, Fan J.
Sci Rep. 2016 Aug 16;6:31663. doi: 10.1038/srep31663.

Exposure to nickel oxide nanoparticles induces pulmonary inflammation through NLRP3inflammasome activation in rats.
Cao Z, Fang Y, Lu Y, Qian F, Ma Q, He M, Pi H, Yu Z, Zhou Z.
Int J Nanomedicine. 2016 Jul 22;11:3331-46. doi: 10.2147/IJN.S106912. eCollection 2016.

Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
Primiano MJ, Lefker BA, Bowman MR, Bree AG, Hubeau C, Bonin PD, Mangan M, Dower K, Monks BG, Cushing L, Wang S, Guzova J, Jiao A, Lin LL, Latz E, Hepworth D, Hall JP.
J Immunol. 2016 Sep 15;197(6):2421-33. doi: 10.4049/jimmunol.1600035. Epub 2016 Aug 12.

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence.
Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B.
Sci Rep. 2016 Aug 1;6:30943. doi: 10.1038/srep30943.

Role of Canonical and Non-canonical Inflammasomes During Burkholderia Infection.
Sahoo M, Lantier L, Re F.
Curr Top Microbiol Immunol. 2016;397:199-214. doi: 10.1007/978-3-319-41171-2_10. Review.

Casticin inhibits lipopolysaccharide-induced acute lung injury in mice.
Wang C, Zeng L, Zhang T, Liu J, Wang W.
Eur J Pharmacol. 2016 Oct 15;789:172-178. doi: 10.1016/j.ejphar.2016.07.035. Epub 2016 Jul 21.

The Nucleotide-Binding Oligomerization Domain-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome Regulates Bronchial Epithelial Cell Injury and Proapoptosis after Exposure to Biomass Fuel Smoke.
Li C, Zhihong H, Wenlong L, Xiaoyan L, Qing C, Wenzhi L, Siming X, Shengming L.
Am J Respir Cell Mol Biol. 2016 Dec;55(6):815-824.

Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation.
Hoyt LR, Ather JL, Randall MJ, DePuccio DP, Landry CC, Wewers MD, Gavrilin MA, Poynter ME.
J Immunol. 2016 Aug 15;197(4):1322-34. doi: 10.4049/jimmunol.1600406. Epub 2016 Jul 15.

CORM-2 inhibits TXNIP/NLRP3 inflammasome pathway in LPS-induced acute lung injury.
Jiang L, Fei D, Gong R, Yang W, Yu W, Pan S, Zhao M, Zhao M.
Inflamm Res. 2016 Nov;65(11):905-915. Epub 2016 Jul 13.

Involvement of EGF receptor signaling and NLRP12 inflammasome in fine particulate matter-induced lung inflammation in mice.
Jin Y, Wu W, Zhang W, Zhao Y, Wu Y, Ge G, Ba Y, Guo Q, Gao T, Chi X, Hao H, Wang J, Feng F.
Environ Toxicol. 2017 Apr;32(4):1121-1134. doi: 10.1002/tox.22308. Epub 2016 Jul 5.

High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation.
Thacker SG, Zarzour A, Chen Y, Alcicek MS, Freeman LA, Sviridov DO, Demosky SJ Jr, Remaley AT.
Immunology. 2016 Nov;149(3):306-319. doi: 10.1111/imm.12638. Epub 2016 Aug 28.

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.
Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O’Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C.
Science. 2016 Jun 17;352(6292):aad1210. doi: 10.1126/science.aad1210.

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition.
Tate MD, Ong JDH, Dowling JK, McAuley JL, Robertson AB, Latz E, Drummond GR, Cooper MA, Hertzog PJ, Mansell A.
Sci Rep. 2016 Jun 10;6:27912. doi: 10.1038/srep27912.

Genipin alleviates LPS-induced acute lung injury by inhibiting NF-κB and NLRP3 signaling pathways.
Zhang A, Wang S, Zhang J, Wu H.
Int Immunopharmacol. 2016 Sep;38:115-9. doi: 10.1016/j.intimp.2016.05.011. Epub 2016 Jun 2.

Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis.
Robert S, Gicquel T, Victoni T, Valença S, Barreto E, Bailly-Maître B, Boichot E, Lagente V.
Biosci Rep. 2016 Jul 15;36(4). pii: e00360. doi: 10.1042/BSR20160107. Print 2016 Aug. Review.

Cold-inducible RNA-binding protein causes endothelial dysfunction via activation of Nlrp3inflammasome.
Yang WL, Sharma A, Wang Z, Li Z, Fan J, Wang P.
Sci Rep. 2016 May 24;6:26571. doi: 10.1038/srep26571.

Endocytosis of indium-tin-oxide nanoparticles by macrophages provokes pyroptosis requiring NLRP3-ASC-Caspase1 axis that can be prevented by mesenchymal stem cells.
Naji A, Muzembo BA, Yagyu K, Baba N, Deschaseaux F, Sensebé L, Suganuma N.
Sci Rep. 2016 May 19;6:26162. doi: 10.1038/srep26162.

Cytokine Profiles in Human Metapneumovirus Infected Children: Identification of Genes Involved in the Antiviral Response and Pathogenesis.
Malmo J, Moe N, Krokstad S, Ryan L, Loevenich S, Johnsen IB, Espevik T, Nordbø SA, Døllner H, Anthonsen MW.
PLoS One. 2016 May 12;11(5):e0155484. doi: 10.1371/journal.pone.0155484. eCollection 2016.

Inflammasome, IL-1 and inflammation in ozone-induced lung injury.
Michaudel C, Couturier-Maillard A, Chenuet P, Maillet I, Mura C, Couillin I, Gombault A, Quesniaux VF, Huaux F, Ryffel B.
Am J Clin Exp Immunol. 2016 Mar 23;5(1):33-40. eCollection 2016. Review.

[Role and mechanism of the NOD-like receptor 3 inflammasome in ventilator-induced lung injury in rats].
Zhang W, Pan L.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Oct;27(10):821-5. Chinese.

ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo.
Kupz A, Zedler U, Stäber M, Perdomo C, Dorhoi A, Brosch R, Kaufmann SH.
J Clin Invest. 2016 Jun 1;126(6):2109-22. doi: 10.1172/JCI84978. Epub 2016 Apr 25.

Inflammasome genetics contributes to the development and control of active pulmonary tuberculosis.
Souza de Lima D, Ogusku MM, Sadahiro A, Pontillo A.
Infect Genet Evol. 2016 Jul;41:240-244. doi: 10.1016/j.meegid.2016.04.015. Epub 2016 Apr 19.

[Effects of Serum Containing Qinbai Qinfei Concentrated Pellets on Expressions of NLRP3Inflammasome in RAW264.7 Cells Infected with Mycoplasma pneumonia].
Zhang H, Suo XB, Zhang YL, Ma J, Zhang SM, Xu QR, Wang WM.
Zhong Yao Cai. 2016 Apr;39(4):876-9. Chinese

Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial Cells.
Xi H, Zhang Y, Xu Y, Yang WY, Jiang X, Sha X, Cheng X, Wang J, Qin X, Yu J, Ji Y, Yang X, Wang H.
Circ Res. 2016 May 13;118(10):1525-39. doi: 10.1161/CIRCRESAHA.116.308501. Epub 2016 Mar 22.

T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.
Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X.
Nat Immunol. 2016 May;17(5):583-92. doi: 10.1038/ni.3389. Epub 2016 Mar 21.

Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation.
Souza AC, Bocharov AV, Baranova IN, Vishnyakova TG, Huang YG, Wilkins KJ, Hu X, Street JM, Alvarez-Prats A, Mullick AE, Patterson AP, Remaley AT, Eggerman TL, Yuen PS, Star RA.
Kidney Int. 2016 Apr;89(4):809-22. doi: 10.1016/j.kint.2015.12.043.

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis.
Iannitti RG, Napolioni V, Oikonomou V, De Luca A, Galosi C, Pariano M, Massi-Benedetti C, Borghi M, Puccetti M, Lucidi V, Colombo C, Fiscarelli E, Lass-Flörl C, Majo F, Cariani L, Russo M, Porcaro L, Ricciotti G, Ellemunter H, Ratclif L, De Benedictis FM, Talesa VN, Dinarello CA, van de Veerdonk FL, Romani L.
Nat Commun. 2016 Mar 14;7:10791. doi: 10.1038/ncomms10791.

IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development.
Stouch AN, McCoy AM, Greer RM, Lakhdari O, Yull FE, Blackwell TS, Hoffman HM, Prince LS.
J Immunol. 2016 Apr 15;196(8):3411-20. doi: 10.4049/jimmunol.1500906. Epub 2016 Mar 7.

Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma.
Kadariya Y, Menges CW, Talarchek J, Cai KQ, Klein-Szanto AJ, Pietrofesa RA, Christofidou-Solomidou M, Cheung M, Mossman BT, Shukla A, Testa JR.
Cancer Prev Res (Phila). 2016 May;9(5):406-414. doi: 10.1158/1940-6207.CAPR-15-0347. Epub 2016 Mar 2.

Age-Dependent Susceptibility to Pulmonary Fibrosis Is Associated with NLRP3 Inflammasome Activation.
Stout-Delgado HW, Cho SJ, Chu SG, Mitzel DN, Villalba J, El-Chemaly S, Ryter SW, Choi AM, Rosas IO.
Am J Respir Cell Mol Biol. 2016 Aug;55(2):252-63. doi: 10.1165/rcmb.2015-0222OC.

Innate recognition of influenza virus and vaccine development.
Ichinohe T.
Uirusu. 2015;65(1):127-34. doi: 10.2222/jsv.65.127. Review. Japanese.

Autophagy and Obesity-Related Lung Disease.
Pabon MA, Ma KC, Choi AM.
Am J Respir Cell Mol Biol. 2016 May;54(5):636-46. doi: 10.1165/rcmb.2016-0045PS. Review.

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome.
Zhang Y, Li X, Grailer JJ, Wang N, Wang M, Yao J, Zhong R, Gao GF, Ward PA, Tan DX, Li X.
J Pineal Res. 2016 May;60(4):405-14. doi: 10.1111/jpi.12322. Epub 2016 Mar 9.

Role of Linear Ubiquitination in Health and Disease.
Brazee P, Dada LA, Sznajder JI.
Am J Respir Cell Mol Biol. 2016 Jun;54(6):761-8. doi: 10.1165/rcmb.2016-0014TR. Review.

Neutrophil extracellular traps are associated with inflammation in chronic airway disease.
Wright TK, Gibson PG, Simpson JL, McDonald VM, Wood LG, Baines KJ.
Respirology. 2016 Apr;21(3):467-75. doi: 10.1111/resp.12730. Epub 2016 Jan 25.

Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice.
Mardare C, Krüger K, Liebisch G, Seimetz M, Couturier A, Ringseis R, Wilhelm J, Weissmann N, Eder K, Mooren FC.
J Diabetes Res. 2016;2016:4536470. doi: 10.1155/2016/4536470. Epub 2015 Dec 14.

Activation of NLRP3 inflammasome enhances the proliferation and migration of A549 lung cancer cells.
Wang Y, Kong H, Zeng X, Liu W, Wang Z, Yan X, Wang H, Xie W.
Oncol Rep. 2016 Apr;35(4):2053-64. doi: 10.3892/or.2016.4569. Epub 2016 Jan 18.

Next generation sequencing revealed DNA ligase IV deficiency in a “developmentally normal” patient with massive brain Epstein-Barr virus-positive diffuse large B-cell lymphoma.
Sharapova SO, Chang EY, Guryanova IE, Proleskovskaya IV, Fedorova AS, Rutskaya EA, Aleinikova OV.
Clin Immunol. 2016 Feb;163:108-10. doi: 10.1016/j.clim.2016.01.002. Epub 2016 Jan 13

Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression.
Galam L, Rajan A, Failla A, Soundararajan R, Lockey RF, Kolliputi N.
Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15;310(6):L572-81. doi: 10.1152/ajplung.00417.2015. Epub 2016 Jan 8.

NLRP3 inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid lung.
Lasithiotaki I, Giannarakis I, Tsitoura E, Samara KD, Margaritopoulos GA, Choulaki C, Vasarmidi E, Tzanakis N, Voloudaki A, Sidiropoulos P, Siafakas NM, Antoniou KM.
Eur Respir J. 2016 Mar;47(3):910-8. doi: 10.1183/13993003.00564-2015. Epub 2016 Jan 7.

Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice.
Li F, Zhang P, Zhang M, Liang L, Sun X, Li M, Tang Y, Bao A, Gong J, Zhang J, Adcock I, Chung KF, Zhou X.
Am J Respir Cell Mol Biol. 2016 Jul;55(1):72-81. doi: 10.1165/rcmb.2015-0014OC.

NLRP3 inflammasome is essential for the development of chronic obstructive pulmonary disease.
Yang W, Ni H, Wang H, Gu H.
Int J Clin Exp Pathol. 2015 Oct 1;8(10):13209-16. eCollection 2015.

Inflammasome Modulation by Chemotherapeutics in Malignant Mesothelioma.
Westbom C, Thompson JK, Leggett A, MacPherson M, Beuschel S, Pass H, Vacek P, Shukla A.
PLoS One. 2015 Dec 21;10(12):e0145404. doi: 10.1371/journal.pone.0145404. eCollection 2015.

Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression.
Yu SX, Du CT, Chen W, Lei QQ, Li N, Qi S, Zhang XJ, Hu GQ, Deng XM, Han WY, Yang YJ.
Sci Rep. 2015 Dec 11;5:17935. doi: 10.1038/srep17935.

The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia.
Liao J, Kapadia VS, Brown LS, Cheong N, Longoria C, Mija D, Ramgopal M, Mirpuri J, McCurnin DC, Savani RC.
Nat Commun. 2015 Nov 27;6:8977. doi: 10.1038/ncomms9977.

Sepsis and ARDS: The Dark Side of Histones.
Xu Z, Huang Y, Mao P, Zhang J, Li Y.
Mediators Inflamm. 2015;2015:205054. doi: 10.1155/2015/205054. Epub 2015 Nov 1. Review

Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation.
Ka SM, Lin JC, Lin TJ, Liu FC, Chao LK, Ho CL, Yeh LT, Sytwu HK, Hua KF, Chen A.
Arthritis Res Ther. 2015 Nov 19;17:331. doi: 10.1186/s13075-015-0844-6.

ROS-Mediated NLRP3 Inflammasome Activity Is Essential for Burn-Induced Acute Lung Injury.
Han S, Cai W, Yang X, Jia Y, Zheng Z, Wang H, Li J, Li Y, Gao J, Fan L, Hu D.
Mediators Inflamm. 2015;2015:720457. doi: 10.1155/2015/720457. Epub 2015 Oct 20.

Blockade of Interplay between IL-17A and Endoplasmic Reticulum Stress Attenuates LPS-Induced Lung Injury.
Kim SR, Kim HJ, Kim DI, Lee KB, Park HJ, Jeong JS, Cho SH, Lee YC.
Theranostics. 2015 Oct 7;5(12):1343-62. doi: 10.7150/thno.11685. eCollection 2015.

Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo.
Huang TT, Lai HC, Ko YF, Ojcius DM, Lan YW, Martel J, Young JD, Chong KY.
Sci Rep. 2015 Oct 26;5:15282. doi: 10.1038/srep15282.

Effects of the Interactions between Dust Exposure and Genetic Polymorphisms in Nalp3, Caspase-1, and IL-1β on the Risk of Silicosis: A Case-Control Study.
Weng S, Wang L, Rong Y, Liu Y, Wang X, Guan H, Chen W.
PLoS One. 2015 Oct 23;10(10):e0140952. doi: 10.1371/journal.pone.0140952. eCollection 2015.

Inflammasomes in COPD and neutrophilic asthma.
Kim RY, Pinkerton JW, Gibson PG, Cooper MA, Horvat JC, Hansbro PM.
Thorax. 2015 Dec;70(12):1199-201. doi: 10.1136/thoraxjnl-2014-206736. Epub 2015 Oct 22. No abstract available.

Carbon monoxide decreases interleukin-1β levels in the lung through the induction of pyrin.
Kim SK, Joe Y, Chen Y, Ryu J, Lee JH, Cho GJ, Ryter SW, Chung HT.
Cell Mol Immunol. 2017 Apr;14(4):349-359. doi: 10.1038/cmi.2015.79. Epub 2015 Oct 19.

Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease.
Lee S, Suh GY, Ryter SW, Choi AM.
Am J Respir Cell Mol Biol. 2016 Feb;54(2):151-60. doi: 10.1165/rcmb.2015-0231TR. Review.

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.
Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B.
PLoS One. 2015 Aug 28;10(8):e0137108. doi: 10.1371/journal.pone.0137108. eCollection 2015.

Tissue-specific expression pattern and histological distribution of NLRP3 in Chinese yellow chicken.
Ye J, Yu M, Zhang K, Liu J, Wang Q, Tao P, Jia K, Liao M, Ning Z.
Vet Res Commun. 2015 Sep;39(3):171-7. doi: 10.1007/s11259-015-9641-6. Epub 2015 Aug 6.

Helicobacter urease-induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma.
Koch KN, Hartung ML, Urban S, Kyburz A, Bahlmann AS, Lind J, Backert S, Taube C, Müller A.
J Clin Invest. 2015 Aug 3;125(8):3297-302. doi: 10.1172/JCI79337. Epub 2015 Jul 27.

Reduction of Acute Inflammatory Effects of Fumed Silica Nanoparticles in the Lung by Adjusting Silanol Display through Calcination and Metal Doping.
Sun B, Pokhrel S, Dunphy DR, Zhang H, Ji Z, Wang X, Wang M, Liao YP, Chang CH, Dong J, Li R, Mädler L, Brinker CJ, Nel AE, Xia T.
ACS Nano. 2015 Sep 22;9(9):9357-72. doi: 10.1021/acsnano.5b03443. Epub 2015 Jul 29.

Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2.
Rajanbabu V, Galam L, Fukumoto J, Enciso J, Tadikonda P, Lane TN, Bandyopadhyay S, Parthasarathy PT, Cho Y, Cho SH, Lee YC, Lockey RF, Kolliputi N.
Cell Immunol. 2015 Sep;297(1):40-5. doi: 10.1016/j.cellimm.2015.06.002. Epub 2015 Jun 16.

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.
Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, Chevriaux A, Limagne E, Apetoh L, Végran F, Ghiringhelli F.
Nat Immunol. 2015 Aug;16(8):859-70. doi: 10.1038/ni.3202. Epub 2015 Jun 22. Erratum in: Nat Immunol. 2015 Dec;16(12):1292.

Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.
Cero FT, Hillestad V, Sjaastad I, Yndestad A, Aukrust P, Ranheim T, Lunde IG, Olsen MB, Lien E, Zhang L, Haugstad SB, Løberg EM, Christensen G, Larsen KO, Skjønsberg OH.
Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L378-87. doi: 10.1152/ajplung.00342.2014. Epub 2015 Jun 12.

Silica-induced inflammasome activation in macrophages: role of ATP and P2X7 receptor.
Luna-Gomes T, Santana PT, Coutinho-Silva R.
Immunobiology. 2015 Sep;220(9):1101-6. doi: 10.1016/j.imbio.2015.05.004. Epub 2015 May 18. Review.

The role of the NLRP3 inflammasome in pulmonary diseases.
Hosseinian N, Cho Y, Lockey RF, Kolliputi N.
Ther Adv Respir Dis. 2015 Aug;9(4):188-97. doi: 10.1177/1753465815586335. Epub 2015 May 26. Review.

Brief Report: Cryopyrin-Associated Periodic Syndrome Caused by a Myeloid-Restricted Somatic NLRP3 Mutation.
Zhou Q, Aksentijevich I, Wood GM, Walts AD, Hoffmann P, Remmers EF, Kastner DL, Ombrello AK.
Arthritis Rheumatol. 2015 Sep;67(9):2482-6. doi: 10.1002/art.39190.

Anti-inflammatory effect of Impatiens textori Miq. extract via inhibition of NLRP3 inflammasome activation in in vitro and in vivo experimental models.
Sun X, Shim DW, Han JW, Shin WY, Sim EJ, Kim MK, Heo KH, Kim YK, Koppula S, Kim TJ, Kang TB, Lee KH.
J Ethnopharmacol. 2015 Jul 21;170:81-7. doi: 10.1016/j.jep.2015.05.001. Epub 2015 May 11.

Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome.
Wang S, Zhao J, Wang H, Liang Y, Yang N, Huang Y.
Int Immunopharmacol. 2015 Jul;27(1):38-45. doi: 10.1016/j.intimp.2015.04.035. Epub 2015 Apr 29

Phosphatidylinositol 3-kinases pathway mediates lung caspase-1 activation and high mobility group box 1 production in a toluene-diisocyanate induced murine asthma model.
Liang J, Zhao H, Yao L, Tang H, Dong H, Wu Y, Liu L, Zou F, Cai S.
Toxicol Lett. 2015 Jul 2;236(1):25-33. doi: 10.1016/j.toxlet.2015.04.011. Epub 2015 Apr 27.

Differential expression of inflammasomes in lung cancer cell lines and tissues.
Kong H, Wang Y, Zeng X, Wang Z, Wang H, Xie W.
Tumour Biol. 2015 Sep;36(10):7501-13. doi: 10.1007/s13277-015-3473-4. Epub 2015 Apr 25.

NLRP3, a Double-edged Sword in Lung Injury Diseases.
Wu JX, Shi KH.
Inflammation. 2015 Oct;38(5):1855-6. doi: 10.1007/s10753-015-0163-8.

Toxin-induced necroptosis is a major mechanism of Staphylococcus aureus lung damage.
Kitur K, Parker D, Nieto P, Ahn DS, Cohen TS, Chung S, Wachtel S, Bueno S, Prince A.
PLoS Pathog. 2015 Apr 16;11(4):e1004820. doi: 10.1371/journal.ppat.1004820. eCollection 2015 Ap

Sintered indium-tin oxide particles induce pro-inflammatory responses in vitro, in part through inflammasome activation.
Badding MA, Schwegler-Berry D, Park JH, Fix NR, Cummings KJ, Leonard SS.
PLoS One. 2015 Apr 13;10(4):e0124368. doi: 10.1371/journal.pone.0124368. eCollection 2015.

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.
Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, Maruya M, Ian McKenzie C, Hijikata A, Wong C, Binge L, Thorburn AN, Chevalier N, Ang C, Marino E, Robert R, Offermanns S, Teixeira MM, Moore RJ, Flavell RA, Fagarasan S, Mackay CR.
Nat Commun. 2015 Apr 1;6:6734. doi: 10.1038/ncomms7734.

IL-18 triggered by the Nlrp3 inflammasome induces host innate resistance in a pulmonary model of fungal infection.
Ketelut-Carneiro N, Silva GK, Rocha FA, Milanezi CM, Cavalcanti-Neto FF, Zamboni DS, Silva JS.
J Immunol. 2015 May 1;194(9):4507-17. doi: 10.4049/jimmunol.1402321. Epub 2015 Mar 30.

The inflammasome accelerates radiation-induced lung inflammation and fibrosis in mice.
Sohn SH, Lee JM, Park S, Yoo H, Kang JW, Shin D, Jung KH, Lee YS, Cho J, Bae H.
Environ Toxicol Pharmacol. 2015 Mar;39(2):917-26. doi: 10.1016/j.etap.2015.02.019. Epub 2015 Mar 7.

Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages.
Jung SS, Moon JS, Xu JF, Ifedigbo E, Ryter SW, Choi AM, Nakahira K.
Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1058-67. doi: 10.1152/ajplung.00400.2014. Epub 2015 Mar 13.

Vimentin regulates activation of the NLRP3 inflammasome.
dos Santos G, Rogel MR, Baker MA, Troken JR, Urich D, Morales-Nebreda L, Sennello JA, Kutuzov MA, Sitikov A, Davis JM, Lam AP, Cheresh P, Kamp D, Shumaker DK, Budinger GR, Ridge KM.
Nat Commun. 2015 Mar 12;6:6574. doi: 10.1038/ncomms7574.

Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases.
Herberth G, Offenberg K, Rolle-Kampczyk U, Bauer M, Otto W, Röder S, Grützmann K, Sack U, Simon JC, Borte M, von Bergen M, Lehmann I; LINA Study Group.
J Allergy Clin Immunol. 2015 Aug;136(2):495-7. doi: 10.1016/j.jaci.2015.01.022. Epub 2015 Mar 7. No abstract available.

Temporal regulation of cytokine mRNA expression by tristetraprolin: dynamic control by p38 MAPK and MKP-1.
Prabhala P, Bunge K, Rahman MM, Ge Q, Clark AR, Ammit AJ.
Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L973-80. doi: 10.1152/ajplung.00219.2014. Epub 2015 Feb 27.

Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation.
Madouri F, Guillou N, Fauconnier L, Marchiol T, Rouxel N, Chenuet P, Ledru A, Apetoh L, Ghiringhelli F, Chamaillard M, Zheng SG, Trovero F, Quesniaux VF, Ryffel B, Togbe D.
J Mol Cell Biol. 2015 Aug;7(4):351-65. doi: 10.1093/jmcb/mjv012. Epub 2015 Feb 24.

A novel synthetic derivative of melatonin, 5-hydroxy-2′-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation.
Shim DW, Shin HJ, Han JW, Ji YE, Jang CH, Koppula S, Kang TB, Lee KH.
Toxicol Appl Pharmacol. 2015 Apr 15;284(2):227-35. doi: 10.1016/j.taap.2015.02.006. Epub 2015 Feb 14.

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, Panek C, Le Bert M, Lagente V, Rassendren F, Riteau N, Couillin I.
Cell Death Dis. 2015 Feb 5;6:e1629. doi: 10.1038/cddis.2014.576.

Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis.
Rimessi A, Bezzerri V, Patergnani S, Marchi S, Cabrini G, Pinton P.
Nat Commun. 2015 Feb 4;6:6201. doi: 10.1038/ncomms7201.

Use of a pro-fibrogenic mechanism-based predictive toxicological approach for tiered testing and decision analysis of carbonaceous nanomaterials.
Wang X, Duch MC, Mansukhani N, Ji Z, Liao YP, Wang M, Zhang H, Sun B, Chang CH, Li R, Lin S, Meng H, Xia T, Hersam MC, Nel AE.
ACS Nano. 2015 Mar 24;9(3):3032-43. doi: 10.1021/nn507243w. Epub 2015 Feb 18.

NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in LungFibrosis by Multiwalled Carbon Nanotubes.
Sun B, Wang X, Ji Z, Wang M, Liao YP, Chang CH, Li R, Zhang H, Nel AE, Xia T.
Small. 2015 May 6;11(17):2087-97. doi: 10.1002/smll.201402859. Epub 2015 Jan 12.

Peroxyauraptenol Inhibits Inflammation and NLRP3 Inflammasome Activation by Inhibiting Reactive Oxygen Species Generation and Preserving Mitochondrial Integrity.
Chao LK, Lin CH, Chiu HW, Wong WT, Chiu HW, Tasi YL, Kuo YH, Chiu YC, Liu ML, Ho CL, Hua KF.
J Agric Food Chem. 2015 Feb 4;63(4):1210-1219. doi: 10.1021/jf5054436. Epub 2015 Jan 22.

NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β.
Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M.
J Biol Chem. 2015 Feb 20;290(8):5065-77. doi: 10.1074/jbc.M114.603217. Epub 2014 Dec 29.

Expression pattern of NLRP3 and its related cytokines in the lung and brain of avian influenza virus H9N2 infected BALB/c mice.
Yu M, Zhang K, Qi W, Huang Z, Ye J, Ma Y, Liao M, Ning Z.
Virol J. 2014 Dec 30;11:229. doi: 10.1186/s12985-014-0229-5

Ellagic acid prevents monocrotaline-induced pulmonary artery hypertension via inhibiting NLRP3inflammasome activation in rats.
Tang B, Chen GX, Liang MY, Yao JP, Wu ZK.
Int J Cardiol. 2015 Feb 1;180:134-41. doi: 10.1016/j.ijcard.2014.11.161. Epub 2014 Nov 25.

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs.
Peeters PM, Eurlings IM, Perkins TN, Wouters EF, Schins RP, Borm PJ, Drommer W, Reynaert NL, Albrecht C.
Part Fibre Toxicol. 2014 Nov 19;11:58. doi: 10.1186/s12989-014-0058-0.

Iron, inflammation, and early death in adults with sickle cell disease.
van Beers EJ, Yang Y, Raghavachari N, Tian X, Allen DT, Nichols JS, Mendelsohn L, Nekhai S, Gordeuk VR, Taylor JG 6th, Kato GJ.
Circ Res. 2015 Jan 16;116(2):298-306. doi: 10.1161/CIRCRESAHA.116.304577. Epub 2014 Nov 6.

IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis.
Moretti S, Bozza S, Oikonomou V, Renga G, Casagrande A, Iannitti RG, Puccetti M, Garlanda C, Kim S, Li S, van de Veerdonk FL, Dinarello CA, Romani L.
PLoS Pathog. 2014 Nov 6;10(11):e1004462. doi: 10.1371/journal.ppat.1004462. eCollection 2014 Nov.

NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation.
Kim SR, Kim DI, Kim SH, Lee H, Lee KS, Cho SH, Lee YC.
Cell Death Dis. 2014 Oct 30;5:e1498. doi: 10.1038/cddis.2014.460.

NLRP3 inflammasome activation is essential for paraquat-induced acute lung injury.
Liu Z, Zhao H, Liu W, Li T, Wang Y, Zhao M.
Inflammation. 2015 Feb;38(1):433-44. doi: 10.1007/s10753-014-0048-2.

Molecular activation of the NLRP3 Inflammasome in fibrosis: common threads linking divergent fibrogenic diseases.
Artlett CM, Thacker JD.
Antioxid Redox Signal. 2015 May 1;22(13):1162-75. doi: 10.1089/ars.2014.6148. Epub 2014 Dec 9. Review.

Immune complexes inhibit IL-1 secretion and inflammasome activation.
Janczy JR, Ciraci C, Haasken S, Iwakura Y, Olivier AK, Cassel SL, Sutterwala FS.
J Immunol. 2014 Nov 15;193(10):5190-8. doi: 10.4049/jimmunol.1400628. Epub 2014 Oct 15.

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.
Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O’Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R.
Nat Genet. 2014 Oct;46(10):1140-6. doi: 10.1038/ng.3089. Epub 2014 Sep 14

NLRP3 inflammasome sequential changes in Staphylococcus aureus-induced mouse model of acute rhinosinusitis.
Wang YJ, Gong GQ, Chen S, Xiong LY, Zhou XX, Huang X, Kong WJ.
Int J Mol Sci. 2014 Sep 9;15(9):15806-20. doi: 10.3390/ijms150915806.

Acapsular Cryptococcus neoformans activates the NLRP3 inflammasome.
Guo C, Chen M, Fa Z, Lu A, Fang W, Sun B, Chen C, Liao W, Meng G.
Microbes Infect. 2014 Oct;16(10):845-54. doi: 10.1016/j.micinf.2014.08.013. Epub 2014 Sep 2.

Involvement of NLRP3 inflammasome in rituximab-induced interstitial lung disease: a case report.
Kong H, Wang Y, Zeng X, Zhu Q, Xie W, Dai S.
J Clin Pharm Ther. 2014 Dec;39(6):691-4. doi: 10.1111/jcpt.12198. Epub 2014 Aug 16.

The nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 μm.
Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D, Hansbro PM, Carlsten C, VanEeden S, Sin DD, McNagny KM, Knight DA.
Am J Respir Cell Mol Biol. 2015 Jan;52(1):96-105. doi: 10.1165/rcmb.2014-0158OC.

Functional relevance of NLRP3 inflammasome-mediated interleukin (IL)-1β during acute allergic airway inflammation.
Ritter M, Straubinger K, Schmidt S, Busch DH, Hagner S, Garn H, Prazeres da Costa C, Layland LE.
Clin Exp Immunol. 2014 Nov;178(2):212-23. doi: 10.1111/cei.12400.

Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts.
Hussain S, Sangtian S, Anderson SM, Snyder RJ, Marshburn JD, Rice AB, Bonner JC, Garantziotis S.
Part Fibre Toxicol. 2014 Jun 10;11:28. doi: 10.1186/1743-8977-11-28.

The effects of morin on lipopolysaccharide-induced acute lung injury by suppressing the lung NLRP3inflammasome.
Tianzhu Z, Shihai Y, Juan D.
Inflammation. 2014 Dec;37(6):1976-83. doi: 10.1007/s10753-014-9930-1.

Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation.
Zhang Y, Liu G, Dull RO, Schwartz DE, Hu G.
Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15;307(2):L173-85. doi: 10.1152/ajplung.00083.2014. Epub 2014 May 16.

Critical role for the NLRP3 inflammasome during acute lung injury.
Grailer JJ, Canning BA, Kalbitz M, Haggadone MD, Dhond RM, Andjelkovic AV, Zetoune FS, Ward PA.
J Immunol. 2014 Jun 15;192(12):5974-83. doi: 10.4049/jimmunol.1400368. Epub 2014 May 2.

Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial lunginfection.
Leissinger M, Kulkarni R, Zemans RL, Downey GP, Jeyaseelan S.
Am J Respir Crit Care Med. 2014 Jun 15;189(12):1461-8. doi: 10.1164/rccm.201311-2103PP. Review.

Extracellular histones in tissue injury and inflammation.
Allam R, Kumar SV, Darisipudi MN, Anders HJ.
J Mol Med (Berl). 2014 May;92(5):465-72. doi: 10.1007/s00109-014-1148-z. Epub 2014 Apr 6. Review.

Critical role of aquaporins in interleukin 1β (IL-1β)-induced inflammation.
Rabolli V, Wallemme L, Lo Re S, Uwambayinema F, Palmai-Pallag M, Thomassen L, Tyteca D, Octave JN, Marbaix E, Lison D, Devuyst O, Huaux F.
J Biol Chem. 2014 May 16;289(20):13937-47. doi: 10.1074/jbc.M113.534594. Epub 2014 Apr 3.

Luteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of NLRP3 inflammasome.
Fan SH, Wang YY, Lu J, Zheng YL, Wu DM, Li MQ, Hu B, Zhang ZF, Cheng W, Shan Q.
PLoS One. 2014 Feb 26;9(2):e89961. doi: 10.1371/journal.pone.0089961. eCollection 2014.

Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1.
Luo YP, Jiang L, Kang K, Fei DS, Meng XL, Nan CC, Pan SH, Zhao MR, Zhao MY.
Int Immunopharmacol. 2014 May;20(1):24-32. doi: 10.1016/j.intimp.2014.02.017. Epub 2014 Feb 26.

The role of the inflammasome in fibrotic respiratory diseases.
Rastrick J, Birrell M.
Minerva Med. 2014 Feb;105(1):9-23. Review.

Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways.
Fanton d’Andon M, Quellard N, Fernandez B, Ratet G, Lacroix-Lamandé S, Vandewalle A, Boneca IG, Goujon JM, Werts C.
PLoS Negl Trop Dis. 2014 Jan 30;8(1):e2664. doi: 10.1371/journal.pntd.0002664. eCollection 2014. Erratum in: PLoS Negl Trop Dis. 2014 Apr;8(4):e2802.

Curcumin: a double hit on malignant mesothelioma.
Miller JM, Thompson JK, MacPherson MB, Beuschel SL, Westbom CM, Sayan M, Shukla A.
Cancer Prev Res (Phila). 2014 Mar;7(3):330-40. doi: 10.1158/1940-6207.CAPR-13-0259. Epub 2014 Jan 15.

Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD.
Di Stefano A, Caramori G, Barczyk A, Vicari C, Brun P, Zanini A, Cappello F, Garofano E, Padovani A, Contoli M, Casolari P, Durham AL, Chung KF, Barnes PJ, Papi A, Adcock I, Balbi B.
Thorax. 2014 Jun;69(6):516-24. doi: 10.1136/thoraxjnl-2012-203062. Epub 2014 Jan 15.

An innate link between obesity and asthma.
Celedón JC, Kolls JK.
Nat Med. 2014 Jan;20(1):19-20. doi: 10.1038/nm.3433. No abstract available.

Targeting reactive oxygen species by edaravone inhalation in a rat hyperoxic lung injury model: role of inflammasome.
Wang C, Ye Z, Zheng J, Liu K, Sun X, Tao H, Liu W.
Undersea Hyperb Med. 2013 Nov-Dec;40(6):505-11.

Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity.
Kim HY, Lee HJ, Chang YJ, Pichavant M, Shore SA, Fitzgerald KA, Iwakura Y, Israel E, Bolger K, Faul J, DeKruyff RH, Umetsu DT.
Nat Med. 2014 Jan;20(1):54-61. doi: 10.1038/nm.3423. Epub 2013 Dec 15.

Tobacco smoke-induced lung fibrosis and emphysema.
Morse D, Rosas IO.
Annu Rev Physiol. 2014;76:493-513. doi: 10.1146/annurev-physiol-021113-170411. Epub 2013 Nov 18. Review.

Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer.
Kim HS, Mendiratta S, Kim J, Pecot CV, Larsen JE, Zubovych I, Seo BY, Kim J, Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs JE, Wei S, Peyton M, Williams N, Gazdar AF, Posner BA, Brekken RA, Sood AK, Deberardinis RJ, Roth MG, Minna JD, White MA.
Cell. 2013 Oct 24;155(3):552-66. doi: 10.1016/j.cell.2013.09.041. Epub 2013 Oct 24

New insights into mechanisms controlling the NLRP3 inflammasome and its role in lung disease.
De Nardo D, De Nardo CM, Latz E.
Am J Pathol. 2014 Jan;184(1):42-54. doi: 10.1016/j.ajpath.2013.09.007. Epub 2013 Oct 30. Review.

NLRP3 and ASC differentially affect the lung transcriptome during pneumococcal pneumonia.
van Lieshout MH, Scicluna BP, Florquin S, van der Poll T.m
J Respir Cell Mol Biol. 2014 Apr;50(4):699-712. doi: 10.1165/rcmb.2013-0015OC.

Genes involved in innate immunity associated with asbestos-related fibrotic changes.
Kukkonen MK, Vehmas T, Piirilä P, Hirvonen A.
Occup Environ Med. 2014 Jan;71(1):48-54. doi: 10.1136/oemed-2013-101555. Epub 2013 Oct 4.

Elevated expression of the NLRP3 inflammasome in neutrophilic asthma.
Simpson JL, Phipps S, Baines KJ, Oreo KM, Gunawardhana L, Gibson PG.
Eur Respir J. 2014 Apr;43(4):1067-76. doi: 10.1183/09031936.00105013. Epub 2013 Oct 17.

The NLRP3 inflammasome: role in airway inflammation.
Im H, Ammit AJ.
Clin Exp Allergy. 2014 Feb;44(2):160-72. doi: 10.1111/cea.12206. Review.

Polyenylpyrrole derivatives inhibit NLRP3 inflammasome activation and inflammatory mediator expression by reducing reactive oxygen species production and mitogen-activated protein kinase activation.
Hua KF, Chou JC, Lam Y, Tasi YL, Chen A, Ka SM, Fang Z, Liu ML, Yang FL, Yang YL, Chiu YC, Wu SH.
PLoS One. 2013 Oct 7;8(10):e76754. doi: 10.1371/journal.pone.0076754. eCollection 2013.

The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury.
Jones HD, Crother TR, Gonzalez-Villalobos RA, Jupelli M, Chen S, Dagvadorj J, Arditi M, Shimada K.
Am J Respir Cell Mol Biol. 2014 Feb;50(2):270-80. doi: 10.1165/rcmb.2013-0087OC.

Inflammation and immune response in COPD: where do we stand?
Rovina N, Koutsoukou A, Koulouris NG.
Mediators Inflamm. 2013;2013:413735. doi: 10.1155/2013/413735. Epub 2013 Jul 15. Review.

Viral infection of the lung: host response and sequelae.
Yoo JK, Kim TS, Hufford MM, Braciale TJ.
J Allergy Clin Immunol. 2013 Dec;132(6):1263-76; quiz 1277. doi: 10.1016/j.jaci.2013.06.006. Epub 2013 Aug 1. Review.

Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1β – A Possible Pathway of Exacerbations in COPD.
Rotta Detto Loria J, Rohmann K, Droemann D, Kujath P, Rupp J, Goldmann T, Dalhoff K.
PLoS One. 2013 Jun 26;8(6):e66818. doi: 10.1371/journal.pone.0066818. Print 2013.

Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells.
Triantafilou K, Kar S, van Kuppeveld FJ, Triantafilou M.
Am J Respir Cell Mol Biol. 2013 Dec;49(6):923-34. doi: 10.1165/rcmb.2013-0032OC.

Transfusion-Related Acute Lung Injury: The Work of DAMPs.
Land WG.
Transfus Med Hemother. 2013 Feb;40(1):3-13. doi: 10.1159/000345688. Epub 2013 Jan 3

NLRP3 deletion protects from hyperoxia-induced acute lung injury.
Fukumoto J, Fukumoto I, Parthasarathy PT, Cox R, Huynh B, Ramanathan GK, Venugopal RB, Allen-Gipson DS, Lockey RF, Kolliputi N.
Am J Physiol Cell Physiol. 2013 Jul 15;305(2):C182-9. doi: 10.1152/ajpcell.00086.2013. Epub 2013 May 1.

Early apoptosis of macrophages modulated by injection of Yersinia pestis YopK promotes progression of primary pneumonic plague.
Peters KN, Dhariwala MO, Hughes Hanks JM, Brown CR, Anderson DM.
PLoS Pathog. 2013;9(4):e1003324. doi: 10.1371/journal.ppat.1003324. Epub 2013 Apr 25.

The nucleotide-binding domain and leucine-rich repeat protein-3 inflammasome is not activated in airway smooth muscle upon toll-like receptor-2 ligation.
Hirota JA, Im H, Rahman MM, Rumzhum NN, Manetsch M, Pascoe CD, Bunge K, Alkhouri H, Oliver BG, Ammit AJ.
Am J Respir Cell Mol Biol. 2013 Oct;49(4):517-24. doi: 10.1165/rcmb.2013-0047OC.

Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells.
Pothlichet J, Meunier I, Davis BK, Ting JP, Skamene E, von Messling V, Vidal SM.
PLoS Pathog. 2013;9(4):e1003256. doi: 10.1371/journal.ppat.1003256. Epub 2013 Apr 11.

Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through impaired pyrin induction.
Xu P, Wen Z, Shi X, Li Y, Fan L, Xiang M, Li A, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J.
J Immunol. 2013 May 15;190(10):5247-55. doi: 10.4049/jimmunol.1203182. Epub 2013 Apr 12.

NLRP3 inflammasomes show high expression in aorta of patients with atherosclerosis.
Zheng F, Xing S, Gong Z, Xing Q.
Heart Lung Circ. 2013 Sep;22(9):746-50. doi: 10.1016/j.hlc.2013.01.012. Epub 2013 Feb 23.

Activation of NLRP3 inflammasome in alveolar macrophages contributes to mechanical stretch-induced lung inflammation and injury.
Wu J, Yan Z, Schwartz DE, Yu J, Malik AB, Hu G.
J Immunol. 2013 Apr 1;190(7):3590-9. doi: 10.4049/jimmunol.1200860. Epub 2013 Feb 22.

Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model.
Sager TM, Wolfarth MW, Andrew M, Hubbs A, Friend S, Chen TH, Porter DW, Wu N, Yang F, Hamilton RF, Holian A.
Nanotoxicology. 2014 May;8(3):317-27. doi: 10.3109/17435390.2013.779757. Epub 2013 Mar 19.

Adult Onset Still’s Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations.
Antoniou KM, Margaritopoulos GA, Giannarakis I, Choulaki C, Fountoulakis N, Siafakas NM, Sidiropoulos P.
Case Rep Med. 2013;2013:981232. doi: 10.1155/2013/981232. Epub 2013 Jan 17.

Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity.
Li R, Wang X, Ji Z, Sun B, Zhang H, Chang CH, Lin S, Meng H, Liao YP, Wang M, Li Z, Hwang AA, Song TB, Xu R, Yang Y, Zink JI, Nel AE, Xia T.
ACS Nano. 2013 Mar 26;7(3):2352-68. doi: 10.1021/nn305567s. Epub 2013 Feb 28.

Silica induces NLRP3 inflammasome activation in human lung epithelial cells.
Peeters PM, Perkins TN, Wouters EF, Mossman BT, Reynaert NL.
Part Fibre Toxicol. 2013 Feb 12;10:3. doi: 10.1186/1743-8977-10-3.

Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome.
Villegas LR, Kluck D, Field C, Oberley-Deegan RE, Woods C, Yeager ME, El Kasmi KC, Savani RC, Bowler RP, Nozik-Grayck E.
Antioxid Redox Signal. 2013 May 10;18(14):1753-64. doi: 10.1089/ars.2012.4799. Epub 2013 Feb 5.

Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation.
Triantafilou K, Kar S, Vakakis E, Kotecha S, Triantafilou M.
Thorax. 2013 Jan;68(1):66-75. doi: 10.1136/thoraxjnl-2012-202182.

Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury.
Kuipers MT, Aslami H, Vlaar AP, Juffermans NP, Tuip-de Boer AM, Hegeman MA, Jongsma G, Roelofs JJ, van der Poll T, Schultz MJ, Wieland CW.
PLoS One. 2012;7(11):e50559. doi: 10.1371/journal.pone.0050559. Epub 2012 Nov 30.

NLRP3 inflammasome activation in murine alveolar macrophages and related lung pathology is associated with MWCNT nickel contamination.
Hamilton RF Jr, Buford M, Xiang C, Wu N, Holian A.
Inhal Toxicol. 2012 Dec;24(14):995-1008. doi: 10.3109/08958378.2012.745633.

Polymorphisms in inflammasome genes and risk of coal workers’ pneumoconiosis in a Chinese population.
Ji X, Hou Z, Wang T, Jin K, Fan J, Luo C, Chen M, Han R, Ni C.
PLoS One. 2012;7(10):e47949. doi: 10.1371/journal.pone.0047949. Epub 2012 Oct 22.

IL-1R signalling is critical for regulation of multi-walled carbon nanotubes-induced acute lunginflammation in C57Bl/6 mice.
Girtsman TA, Beamer CA, Wu N, Buford M, Holian A.
Nanotoxicology. 2014 Feb;8(1):17-27. doi: 10.3109/17435390.2012.744110. Epub 2012 Nov 14.

Hyaluronan activation of the Nlrp3 inflammasome contributes to the development of airway hyperresponsiveness.
Feng F, Li Z, Potts-Kant EN, Wu Y, Foster WM, Williams KL, Hollingsworth JW.
Environ Health Perspect. 2012 Dec;120(12):1692-8. doi: 10.1289/ehp.1205188. Epub 2012 Sep 24. Retraction in: Environ Health Perspect. 2015 Jul;123(7):A172.

NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases.
Chow MT, Sceneay J, Paget C, Wong CS, Duret H, Tschopp J, Möller A, Smyth MJ.
Cancer Res. 2012 Nov 15;72(22):5721-32. doi: 10.1158/0008-5472.CAN-12-0509. Epub 2012 Sep 17.

Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lungantibacterial responses.
Dela Cruz CS, Liu W, He CH, Jacoby A, Gornitzky A, Ma B, Flavell R, Lee CG, Elias JA.
Cell Host Microbe. 2012 Jul 19;12(1):34-46. doi: 10.1016/j.chom.2012.05.017.

The Role of the NLRP3 Inflammasome in Fibrosis.
Artlett CM.
Open Rheumatol J. 2012;6:80-6. doi: 10.2174/1874312901206010080. Epub 2012 Jun 15.

NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice.
Kovarova M, Hesker PR, Jania L, Nguyen M, Snouwaert JN, Xiang Z, Lommatzsch SE, Huang MT, Ting JP, Koller BH.
J Immunol. 2012 Aug 15;189(4):2006-16. doi: 10.4049/jimmunol.1201065. Epub 2012 Jun 29.

Ventilator-induced lung injury is mediated by the NLRP3 inflammasome.
Kuipers MT, Aslami H, Janczy JR, van der Sluijs KF, Vlaar AP, Wolthuis EK, Choi G, Roelofs JJ, Flavell RA, Sutterwala FS, Bresser P, Leemans JC, van der Poll T, Schultz MJ, Wieland CW.
Anesthesiology. 2012 May;116(5):1104-15. doi: 10.1097/ALN.0b013e3182518bc0.

Immunolocalization of NLRP3 Inflammasome in Normal Murine Airway Epithelium and Changes following Induction of Ovalbumin-Induced Airway Inflammation.
Tran HB, Lewis MD, Tan LW, Lester SE, Baker LM, Ng J, Hamilton-Bruce MA, Hill CL, Koblar SA, Rischmueller M, Ruffin RE, Wormald PJ, Zalewski PD, Lang CJ.
J Allergy (Cairo). 2012;2012:819176. doi: 10.1155/2012/819176. Epub 2012 Mar 18.

Biological insights from clinical trials and networks.
Thannickal VJ, Hagood JS.
Am J Respir Crit Care Med. 2012 Mar 1;185(5):475-6. doi: 10.1164/rccm.201201-0047ED. No abstract available.

Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin.
Stout-Delgado HW, Vaughan SE, Shirali AC, Jaramillo RJ, Harrod KS.
J Immunol. 2012 Mar 15;188(6):2815-24. doi: 10.4049/jimmunol.1103051. Epub 2012 Feb 10.

Analysis of NLRP3 in the development of allergic airway disease in mice.
Allen IC, Jania CM, Wilson JE, Tekeppe EM, Hua X, Brickey WJ, Kwan M, Koller BH, Tilley SL, Ting JP.
J Immunol. 2012 Mar 15;188(6):2884-93. doi: 10.4049/jimmunol.1102488. Epub 2012 Feb 8.

Staphylococcus aureus α-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome.
Kebaier C, Chamberland RR, Allen IC, Gao X, Broglie PM, Hall JD, Jania C, Doerschuk CM, Tilley SL, Duncan JA.
J Infect Dis. 2012 Mar 1;205(5):807-17. doi: 10.1093/infdis/jir846. Epub 2012 Jan 25.

Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation.
Xu JF, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estépar RS, Diaz AA, Li HP, Qu JM, Himes BE, Come CE, D’Aco K, Martinez FJ, Han MK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AM, Hunninghake GM; COPDGene Investigators.
Am J Respir Crit Care Med. 2012 Mar 1;185(5):547-56. doi: 10.1164/rccm.201108-1574OC. Epub 2012 Jan 12.

Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lunginfection while IL-1β is deleterious.
Ceballos-Olvera I, Sahoo M, Miller MA, Del Barrio L, Re F.
PLoS Pathog. 2011 Dec;7(12):e1002452. doi: 10.1371/journal.ppat.1002452. Epub 2011 Dec 29.

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter.
Hirota JA, Hirota SA, Warner SM, Stefanowicz D, Shaheen F, Beck PL, Macdonald JA, Hackett TL, Sin DD, Van Eeden S, Knight DA.
J Allergy Clin Immunol. 2012 Apr;129(4):1116-25.e6. doi: 10.1016/j.jaci.2011.11.033. Epub 2012 Jan 9.

Bench-to-bedside review: Damage-associated molecular patterns in the onset of ventilator-induced lung injury.
Kuipers MT, van der Poll T, Schultz MJ, Wieland CW.
Crit Care. 2011;15(6):235. doi: 10.1186/cc10437. Epub 2011 Nov 30. Review.

NALP-3 inflammasome silencing attenuates ceramide-induced transepithelial permeability.
Kolliputi N, Galam L, Parthasarathy PT, Tipparaju SM, Lockey RF.
J Cell Physiol. 2012 Sep;227(9):3310-6. doi: 10.1002/jcp.24026.

Inflammasome-IL-1-Th17 response in allergic lung inflammation.
Besnard AG, Togbe D, Couillin I, Tan Z, Zheng SG, Erard F, Le Bert M, Quesniaux V, Ryffel B.
J Mol Cell Biol. 2012 Feb;4(1):3-10. doi: 10.1093/jmcb/mjr042. Epub 2011 Dec 6. Review.


A novel mutation of IL1RN in the deficiency of interleukin-1 receptor antagonist syndrome: description of two unrelated cases from Brazil.
Jesus AA, Osman M, Silva CA, Kim PW, Pham TH, Gadina M, Yang B, Bertola DR, Carneiro-Sampaio M, Ferguson PJ, Renshaw BR, Schooley K, Brown M, Al-Dosari A, Al-Alami J, Sims JE, Goldbach-Mansky R, El-Shanti H.
Arthritis Rheum. 2011 Dec;63(12):4007-17. doi: 10.1002/art.30588.

Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis.
Dorhoi A, Nouailles G, Jörg S, Hagens K, Heinemann E, Pradl L, Oberbeck-Müller D, Duque-Correa MA, Reece ST, Ruland J, Brosch R, Tschopp J, Gross O, Kaufmann SH.
Eur J Immunol. 2012 Feb;42(2):374-84. doi: 10.1002/eji.201141548. Epub 2011 Dec 20.

Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells.
Xiang M, Shi X, Li Y, Xu J, Yin L, Xiao G, Scott MJ, Billiar TR, Wilson MA, Fan J.
J Immunol. 2011 Nov 1;187(9):4809-17. doi: 10.4049/jimmunol.1102093. Epub 2011 Sep 21.

IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis.
Gasse P, Riteau N, Vacher R, Michel ML, Fautrel A, di Padova F, Fick L, Charron S, Lagente V, Eberl G, Le Bert M, Quesniaux VF, Huaux F, Leite-de-Moraes M, Ryffel B, Couillin I.
PLoS One. 2011;6(8):e23185. doi: 10.1371/journal.pone.0023185. Epub 2011 Aug 16.

NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation.
Provoost S, Maes T, Pauwels NS, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Tournoy KG.
J Immunol. 2011 Sep 15;187(6):3331-7. doi: 10.4049/jimmunol.1004062. Epub 2011 Aug 15.

The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis.
Artlett CM, Sassi-Gaha S, Rieger JL, Boesteanu AC, Feghali-Bostwick CA, Katsikis PD.
Arthritis Rheum. 2011 Nov;63(11):3563-74. doi: 10.1002/art.30568.

Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection.
Shimada K, Crother TR, Karlin J, Chen S, Chiba N, Ramanujan VK, Vergnes L, Ojcius DM, Arditi M.
PLoS One. 2011;6(6):e21477. doi: 10.1371/journal.pone.0021477. Epub 2011 Jun 23.

The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia.
Witzenrath M, Pache F, Lorenz D, Koppe U, Gutbier B, Tabeling C, Reppe K, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.
J Immunol. 2011 Jul 1;187(1):434-40. doi: 10.4049/jimmunol.1003143. Epub 2011 Jun 6.

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.
Chang YJ, Kim HY, Albacker LA, Baumgarth N, McKenzie AN, Smith DE, Dekruyff RH, Umetsu DT.
Nat Immunol. 2011 May 29;12(7):631-8. doi: 10.1038/ni.2045.

Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice.
Ather JL, Ckless K, Martin R, Foley KL, Suratt BT, Boyson JE, Fitzgerald KA, Flavell RA, Eisenbarth SC, Poynter ME.
J Immunol. 2011 Jul 1;187(1):64-73. doi: 10.4049/jimmunol.1100500. Epub 2011 May 27.

Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD.
Pauwels NS, Bracke KR, Dupont LL, Van Pottelberge GR, Provoost S, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Brusselle GG.
Eur Respir J. 2011 Nov;38(5):1019-28. doi: 10.1183/09031936.00158110. Epub 2011 May 26.

An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma.
Kool M, Willart MA, van Nimwegen M, Bergen I, Pouliot P, Virchow JC, Rogers N, Osorio F, Reis e Sousa C, Hammad H, Lambrecht BN.
Immunity. 2011 Apr 22;34(4):527-40. doi: 10.1016/j.immuni.2011.03.015. Epub 2011 Apr 7. Erratum in: Immunity. 2011 Apr 22;34(4):627. Reis E Sousa, Caetano [corrected to Reis e Sousa, Caetano]..

Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses.
Yu M, Levine SJ.
Cytokine Growth Factor Rev. 2011 Apr;22(2):63-72. doi: 10.1016/j.cytogfr.2011.02.001. Epub 2011 Apr 3. Review.

NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant.
Besnard AG, Guillou N, Tschopp J, Erard F, Couillin I, Iwakura Y, Quesniaux V, Ryffel B, Togbe D.
Allergy. 2011 Aug;66(8):1047-57. doi: 10.1111/j.1398-9995.2011.02586.x. Epub 2011 Mar 28.

TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis.
Hoque R, Sohail M, Malik A, Sarwar S, Luo Y, Shah A, Barrat F, Flavell R, Gorelick F, Husain S, Mehal W.
Gastroenterology. 2011 Jul;141(1):358-69. doi: 10.1053/j.gastro.2011.03.041. Epub 2011 Mar 24.

The role of the NLRP3 inflammasome in the pathogenesis of airway disease.
Birrell MA, Eltom S.
Pharmacol Ther. 2011 Jun;130(3):364-70. doi: 10.1016/j.pharmthera.2011.03.007. Epub 2011 Mar 21. Review.

Proposed pathobiologic mechanisms of hypoxia-ischemia-reperfusion in corticosteroid-resistant neutrophilic asthma and consideration of interleukin 1 targeted therapy.
Wanderer AA.
Ann Allergy Asthma Immunol. 2011 Jan;106(1):69-72. doi: 10.1016/j.anai.2010.09.007. No abstract available.

[Progress in research on role of inflammasome Nalp3 in silica dusts induced body injuries].
Zhou Y, Zhou T, Guo JL.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010 Oct;28(10):795-8. Review. Chinese. No abstract available.

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β.
Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, Tschopp J.
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19449-54. doi: 10.1073/pnas.1008155107. Epub 2010 Oct 25.

[Immunological effects of silica/asbestos].
Kumagai N, Nishimura Y, Maeda M, Hayashi H, Otsuki T.
Nihon Eiseigaku Zasshi. 2010 Sep;65(4):493-9. Review. Japanese.

Inflammasome-mediated autoinflammatory disorders.
Wilson SP, Cassel SL.
Postgrad Med. 2010 Sep;122(5):125-33. doi: 10.3810/pgm.2010.09.2209. Review.

Airborne Asian sand dust enhances murine lung eosinophilia.
He M, Ichinose T, Yoshida S, Nishikawa M, Mori I, Yanagisawa R, Takano H, Inoue K, Sun G, Shibamoto T.
Inhal Toxicol. 2010 Oct;22(12):1012-25. doi: 10.3109/08958378.2010.510151.

Monogenic autoinflammatory diseases: new insights into clinical aspects and pathogenesis.
Henderson C, Goldbach-Mansky R.
Curr Opin Rheumatol. 2010 Sep;22(5):567-78. doi: 10.1097/BOR.0b013e32833ceff4. Review.

NALP3 is not necessary for early protection against experimental tuberculosis.
Walter K, Hölscher C, Tschopp J, Ehlers S.
Immunobiology. 2010 Sep-Oct;215(9-10):804-11. doi: 10.1016/j.imbio.2010.05.015. Epub 2010 Jun 4.

Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis.
Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, Fick L, Kanellopoulos J, Quesniaux VF, Marchand-Adam S, Crestani B, Ryffel B, Couillin I.
Am J Respir Crit Care Med. 2010 Sep 15;182(6):774-83. doi: 10.1164/rccm.201003-0359OC. Epub 2010 Jun 3.

Inflammasome and IL-1beta-mediated disorders.
Hoffman HM, Wanderer AA.
Curr Allergy Asthma Rep. 2010 Jul;10(4):229-35. doi: 10.1007/s11882-010-0109-z. Review.

Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome.
He X, Mekasha S, Mavrogiorgos N, Fitzgerald KA, Lien E, Ingalls RR.
J Immunol. 2010 May 15;184(10):5743-54. doi: 10.4049/jimmunol.0903937. Epub 2010 Apr 14.

NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways.
Willingham SB, Allen IC, Bergstralh DT, Brickey WJ, Huang MT, Taxman DJ, Duncan JA, Ting JP.
J Immunol. 2009 Aug 1;183(3):2008-15. doi: 10.4049/jimmunol.0900138. Epub 2009 Jul 8.

The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.
Thomas PG, Dash P, Aldridge JR Jr, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD.
Immunity. 2009 Apr 17;30(4):566-75. doi: 10.1016/j.immuni.2009.02.006. Epub 2009 Apr 9.

Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.
Gasse P, Riteau N, Charron S, Girre S, Fick L, Pétrilli V, Tschopp J, Lagente V, Quesniaux VF, Ryffel B, Couillin I.
Am J Respir Crit Care Med. 2009 May 15;179(10):903-13. doi: 10.1164/rccm.200808-1274OC. Epub 2009 Feb 12.

Interleukin-1beta targeted therapy in severe persistent asthma (SPA) and chronic obstructive pulmonary disease (COPD): proposed similarities between biphasic pathobiology of SPA/COPD and ischemia-reperfusion injury.
Wanderer AA.
Isr Med Assoc J. 2008 Dec;10(12):837-42.

Smoke particulates stress lung cells.
Adair-Kirk TL, Atkinson JJ, Senior RM.
Nat Med. 2008 Oct;14(10):1024-5. doi: 10.1038/nm1008-1024. No abstract available.

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E.
Nat Immunol. 2008 Aug;9(8):847-56. doi: 10.1038/ni.1631. Epub 2008 Jul 11.

The Nalp3 inflammasome is essential for the development of silicosis.
Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS.
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9035-40. doi: 10.1073/pnas.0803933105. Epub 2008 Jun 24.

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
Dostert C, Pétrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J.
Science. 2008 May 2;320(5876):674-7. doi: 10.1126/science.1156995. Epub 2008 Apr 10.

Induction of toll-like receptors and NALP/PAN/PYPAF family members by modified oligonucleotides in lung epithelial carcinoma cells.
Drygin D, Koo S, Perera R, Barone S, Bennett CF.
Oligonucleotides. 2005 Summer;15(2):105-18.