Select Page

Are You CovidMune?™

Estrogen and NLRP3

Sex differences in inflammation, redox biology, mitochondria and autoimmunity.
Di Florio DN, Sin J, Coronado MJ, Atwal PS, Fairweather D.
Redox Biol. 2020 Mar 4:101482. doi: 10.1016/j.redox.2020.101482. [Epub ahead of print] Review.

Estrogen deficiency aggravates apical periodontitis by regulating NLRP3/caspase-1/IL-1β axis.
Guan X, Guan Y, Shi C, Zhu X, He Y, Wei Z, Yang J, Hou T.
Am J Transl Res. 2020 Feb 15;12(2):660-671. eCollection 2020.

G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense.
Bai N, Zhang Q, Zhang W, Liu B, Yang F, Brann D, Wang R.
J Neuroinflammation. 2020 Feb 1;17(1):45. doi: 10.1186/s12974-020-1715-x.

Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as new classes of NLRP3inflammasome inhibitors via ER-β structure based virtual screening.
Abdullaha M, Ali M, Kour D, Kumar A, Bharate SB.
Bioorg Chem. 2020 Jan;95:103500. doi: 10.1016/j.bioorg.2019.103500. Epub 2019 Dec 9.

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3signaling pathway.
Bai Y, Li Z, Liu W, Gao D, Liu M, Zhang P.
Acta Cir Bras. 2019 Dec 20;34(11):e201901104. doi: 10.1590/s0102-865020190110000004. eCollection 2019.

Biochanin A protects against angiotensin II-induced damage of dopaminergic neurons in rats associated with the increased endophilin A2 expression.
Xue HX, Kong H, Yu YG, Zhou JW, Chen HQ, Yin YY.
Behav Pharmacol. 2019 Dec;30(8):700-711. doi: 10.1097/FBP.0000000000000515.

NLRP3 inflammasome activation by estrogen promotes the progression of human endometrial cancer.
Liu SG, Wu XX, Hua T, Xin XY, Feng DL, Chi SQ, Wang XX, Wang HB.
Onco Targets Ther. 2019 Aug 27;12:6927-6936. doi: 10.2147/OTT.S218240. eCollection 2019.

Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota.
Sabui S, Skupsky J, Kapadia R, Cogburn K, Lambrecht NW, Agrawal A, Said HM.
Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G518-G530. doi: 10.1152/ajpgi.00172.2019. Epub 2019 Aug 1.

Estrogen receptor alpha regulates the Wnt/β-catenin signaling pathway in colon cancer by targeting the NOD-like receptors.
Liu S, Fan W, Gao X, Huang K, Ding C, Ma G, Yan L, Song S.
Cell Signal. 2019 Sep;61:86-92. doi: 10.1016/j.cellsig.2019.05.009. Epub 2019 May 20.

NLRP3 inhibition improves heart function in GPER knockout mice.
Wang H, Sun X, Hodge HS, Ferrario CM, Groban L.
Biochem Biophys Res Commun. 2019 Jun 30;514(3):998-1003. doi: 10.1016/j.bbrc.2019.05.045. Epub 2019 May 12.

Mono-(2-ethylhexyl) Phthalate Aggravates Inflammatory Response via Sirtuin Regulation and Inflammasome Activation in RAW 264.7 Cells.
Park MH, Gutiérrez-García AK, Choudhury M.
Chem Res Toxicol. 2019 May 20;32(5):935-942. doi: 10.1021/acs.chemrestox.9b00101. Epub 2019 May 8.

E2-Induced Activation of the NLRP3 Inflammasome Triggers Pyroptosis and Inhibits Autophagy in HCC Cells.
Wei Q, Zhu R, Zhu J, Zhao R, Li M.
Oncol Res. 2019 Jul 12;27(7):827-834. doi: 10.3727/096504018X15462920753012. Epub 2019 Mar 25.

Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.
Chen KW, Demarco B, Heilig R, Shkarina K, Boettcher A, Farady CJ, Pelczar P, Broz P.
EMBO J. 2019 May 15;38(10). pii: e101638. doi: 10.15252/embj.2019101638. Epub 2019 Mar 22.

Genistein protects against DSS-induced colitis by inhibiting NLRP3

 inflammasome via TGR5-cAMP signaling.Chen Y, Le TH, Du Q, Zhao Z, Liu Y, Zou J, Hua W, Liu C, Zhu Y.
Int Immunopharmacol. 2019 Jun;71:144-154. doi: 10.1016/j.intimp.2019.01.021. Epub 2019 Mar 19.

Estrogen receptors participate in carcinogenesis signaling pathways by directly regulating NOD-like receptors.
Fan W, Gao X, Ding C, Lv Y, Shen T, Ma G, Yan L, Song S.
Biochem Biophys Res Commun. 2019 Apr 2;511(2):468-475. doi: 10.1016/j.bbrc.2019.02.085. Epub 2019 Feb 21.

Growth of breast cancer cells by leptin is mediated via activation of the inflammasome: Critical roles of estrogen

 receptor signaling and reactive oxygen species production.Raut PK, Kim SH, Choi DY, Jeong GS, Park PH.
Biochem Pharmacol. 2019 Mar;161:73-88. doi: 10.1016/j.bcp.2019.01.006. Epub 2019 Jan 10.

GEN-27 exhibits anti-inflammatory effects by suppressing the activation of NLRP3 inflammasome and NF-κB pathway.
Hu M, Li X, Zhang J, Yuan Z, Fu Y, Ma X, Ren N.
Cell Biol Int. 2019 Oct;43(10):1184-1192. doi: 10.1002/cbin.11101. Epub 2019 Aug 4.

Resveratrol ameliorates estrogen deficiency-induced depression- and anxiety-like behaviors and hippocampal inflammation in mice.
Liu T, Ma Y, Zhang R, Zhong H, Wang L, Zhao J, Yang L, Fan X.
Psychopharmacology (Berl). 2019 Apr;236(4):1385-1399. doi: 10.1007/s00213-018-5148-5. Epub 2019 Jan 4.

Rapamycin‑induced autophagy attenuates hormone‑imbalance‑induced chronic non‑bacterial prostatitis in rats via the inhibition of NLRP3 inflammasome‑mediated inflammation.
Lu J, Su Y, Chen X, Chen Y, Luo P, Lin F, Zhang J.
Mol Med Rep. 2019 Jan;19(1):221-230. doi: 10.3892/mmr.2018.9683. Epub 2018 Nov 21.

Estrogen ameliorates allergic airway inflammation by regulating activation of NLRP3 in mice.
Cheng C, Wu H, Wang M, Wang L, Zou H, Li S, Liu R.
Biosci Rep. 2019 Jan 8;39(1). pii: BSR20181117. doi: 10.1042/BSR20181117. Print 2019 Jan 31.

Zearalenone can relieve dextran sulfate sodium-induced inflammatory reaction.
Ding C, Fan W, Shen T, Huang K, Song S, Yan L.
J Biochem Mol Toxicol. 2018 Oct 1:e22236. doi: 10.1002/jbt.22236. [Epub ahead of print]

NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice.
Inzaugarat ME, Johnson CD, Holtmann TM, McGeough MD, Trautwein C, Papouchado BG, Schwabe R, Hoffman HM, Wree A, Feldstein AE.
Hepatology. 2019 Feb;69(2):845-859. doi: 10.1002/hep.30252. Epub 2019 Jan 3.

The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice.
Wang J, Wang L, Zhou J, Qin A, Chen Z.
Biomed Pharmacother. 2018 Oct;106:1250-1257. doi: 10.1016/j.biopha.2018.07.063. Epub 2018 Jul 20.

Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development.
Son HJ, Sohn SH, Kim N, Lee HN, Lee SM, Nam RH, Park JH, Song CH, Shin E, Na HY, Kim JS, Lee DH, Surh YJ.
Cancer Res Treat. 2019 Apr;51(2):632-648. doi: 10.4143/crt.2018.060. Epub 2018 Aug 1.

17β-Estradiol Regulates Microglia Activation and Polarization in the Hippocampus Following Global Cerebral Ischemia.
Thakkar R, Wang R, Wang J, Vadlamudi RK, Brann DW.
Oxid Med Cell Longev. 2018 Apr 18;2018:4248526. doi: 10.1155/2018/4248526. eCollection 2018.

Melatonin Suppresses Estrogen Deficiency-Induced Osteoporosis and Promotes Osteoblastogenesis by Inactivating the NLRP3 Inflammasome.
Xu L, Zhang L, Wang Z, Li C, Li S, Li L, Fan Q, Zheng L.
Calcif Tissue Int. 2018 Oct;103(4):400-410. doi: 10.1007/s00223-018-0428-y. Epub 2018 May 26.

Impact of steroid hormones E2 and P on the NLRP3/ASC/Casp1 axis in primary mouse astroglia and BV-2 cells after in vitro hypoxia.
Slowik A, Lammerding L, Zendedel A, Habib P, Beyer C.
J Steroid Biochem Mol Biol. 2018 Oct;183:18-26. doi: 10.1016/j.jsbmb.2018.05.003. Epub 2018 May 15.

Chronic Amyloid β Oligomer Infusion Evokes Sustained Inflammation and Microglial Changes in the Rat Hippocampus via NLRP3.
Fekete C, Vastagh C, Dénes Á, Hrabovszky E, Nyiri G, Kalló I, Liposits Z, Sárvári M.
Neuroscience. 2019 May 1;405:35-46. doi: 10.1016/j.neuroscience.2018.02.046. Epub 2018 Mar 6.

Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway.
Wu D, Wu K, Zhu Q, Xiao W, Shan Q, Yan Z, Wu J, Deng B, Xue Y, Gong W, Lu G, Ding Y.
Mediators Inflamm. 2018 Jan 8;2018:3048532. doi: 10.1155/2018/3048532. eCollection 2018. Erratum in: Mediators Inflamm. 2018 Sep 6;2018:9878120

Estradiol inhibits NLRP3 inflammasome in fibroblast-like synoviocytes activated by lipopolysaccharide and adenosine triphosphate.
Shi J, Zhao W, Ying H, Zhang Y, Du J, Chen S, Li J, Shen B.
Int J Rheum Dis. 2018 Nov;21(11):2002-2010. doi: 10.1111/1756-185X.13198. Epub 2017 Nov 3.

Zearalenone (ZEA)-induced intestinal inflammation is mediated by the NLRP3 inflammasome.
Fan W, Lv Y, Ren S, Shao M, Shen T, Huang K, Zhou J, Yan L, Song S.
Chemosphere. 2018 Jan;190:272-279. doi: 10.1016/j.chemosphere.2017.09.145. Epub 2017 Sep 30.

X-11-5-27, a daidzein derivative, inhibits NLRP3 inflammasome activity via promoting autophagy.
Zhou W, Liu X, Cheng K, Zhang X, Lu J, Hu R.
Exp Cell Res. 2017 Nov 15;360(2):320-327. doi: 10.1016/j.yexcr.2017.09.022. Epub 2017 Sep 20.

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation.
Alippe Y, Wang C, Ricci B, Xiao J, Qu C, Zou W, Novack DV, Abu-Amer Y, Civitelli R, Mbalaviele G.
Sci Rep. 2017 Jul 26;7(1):6630. doi: 10.1038/s41598-017-07014-0.

Estrogen Attenuates Local Inflammasome Expression and Activation after Spinal Cord Injury.
Zendedel A, Mönnink F, Hassanzadeh G, Zaminy A, Ansar MM, Habib P, Slowik A, Kipp M, Beyer C.
Mol Neurobiol. 2018 Feb;55(2):1364-1375. doi: 10.1007/s12035-017-0400-2. Epub 2017 Jan 27.

Administration of 17β-Estradiol Improves Motoneuron Survival and Down-regulates Inflammasome Activation in Male SOD1(G93A) ALS Mice.
Heitzer M, Kaiser S, Kanagaratnam M, Zendedel A, Hartmann P, Beyer C, Johann S.
Mol Neurobiol. 2017 Dec;54(10):8429-8443. doi: 10.1007/s12035-016-0322-4. Epub 2016 Dec 12. Erratum in: Mol Neurobiol. 2017 Jan 19;:

NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17β-Estradiol.
Thakkar R, Wang R, Sareddy G, Wang J, Thiruvaiyaru D, Vadlamudi R, Zhang Q, Brann D.
Oxid Med Cell Longev. 2016;2016:8309031. Epub 2016 Oct 23.

IL-18BP is decreased in osteoporotic women: Prevents Inflammasome mediated IL-18 activation and reduces Th17 differentiation.
Mansoori MN, Shukla P, Kakaji M, Tyagi AM, Srivastava K, Shukla M, Dixit M, Kureel J, Gupta S, Singh D.
Sci Rep. 2016 Sep 21;6:33680. doi: 10.1038/srep33680.

Ameliorative effect of dietary genistein on diabetes induced hyper-inflammation and oxidative stress during early stage of wound healing in alloxan induced diabetic mice.
Eo H, Lee HJ, Lim Y.
Biochem Biophys Res Commun. 2016 Sep 23;478(3):1021-7. doi: 10.1016/j.bbrc.2016.07.039. Epub 2016 Jul 16.

Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation.
Liu X, Wang T, Liu X, Cai L, Qi J, Zhang P, Li Y.
Int Immunopharmacol. 2016 Sep;38:324-31. doi: 10.1016/j.intimp.2016.06.009. Epub 2016 Jun 23.

Exercise amelioration of depression-like behavior in OVX mice is associated with suppression of NLRP3 inflammasome activation in hippocampus.
Wang Y, Xu Y, Sheng H, Ni X, Lu J.
Behav Brain Res. 2016 Jul 1;307:18-24. doi: 10.1016/j.bbr.2016.03.044. Epub 2016 Mar 29.

NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice.
Xu Y, Sheng H, Bao Q, Wang Y, Lu J, Ni X.
Brain Behav Immun. 2016 Aug;56:175-86. doi: 10.1016/j.bbi.2016.02.022. Epub 2016 Feb 27.

Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain.
Lammerding L, Slowik A, Johann S, Beyer C, Zendedel A.
Neuroendocrinology. 2016;103(5):460-75. doi: 10.1159/000439435. Epub 2015 Aug 25.

Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells.
Panchanathan R, Liu H, Leung YK, Ho SM, Choubey D.
Mol Cell Endocrinol. 2015 Nov 5;415:45-55. doi: 10.1016/j.mce.2015.08.003. Epub 2015 Aug 12.

17β-Estradiol transcriptionally modulates Nlrp1 and Nlrp3 inflammasomes in gonadectomized rats with inflammation.
Gómez López M, Domínguez López A, Abarca Rojano E, Rojas Hernández S, Martínez Godínez Mde L, Miliar García A, Campos Rodríguez R.
Immunopharmacol Immunotoxicol. 2015;37(4):343-50. doi: 10.3109/08923973.2015.1059439. Epub 2015 Jul 8.

Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome.
Wei Q, Guo P, Mu K, Zhang Y, Zhao W, Huai W, Qiu Y, Li T, Ma X, Liu Y, Chen X, Han L.
Lab Invest. 2015 Jul;95(7):804-16. doi: 10.1038/labinvest.2015.63. Epub 2015 May 25.