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Sulforaphane and NLRP3

Sulforaphane Prevents Right Ventricular Injury and Reduces Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
Kang Y, Zhang G, Huang EC, Huang J, Cai J, Cai L, Wang S, Keller BB.
Am J Physiol Heart Circ Physiol. 2020 Feb 28. doi: 10.1152/ajpheart.00321.2019. [Epub ahead of print]

Sulforaphane alleviates retinal ganglion cell death and inflammation by suppressing NLRP3inflammasome activation in a rat model of retinal ischemia/reperfusion
Gong Y, Cao X, Gong L, Li W.
Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419861777. doi: 10.1177/2058738419861777.

Protective effects of sulforaphane on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of NLRP3 inflammasome formation.
Li S, Yang H, Chen X.
Exp Anim. 2019 May 8;68(2):221-231. doi: 10.1538/expanim.18-0146. Epub 2019 Jan 1.

Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease.
Li Y, Liu Y, Yan X, Liu Q, Zhao YH, Wang DW.
Am J Chin Med. 2018;46(8):1727-1741. doi: 10.1142/S0192415X18500878. Epub 2018 Dec 10. Review.

Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation.
Yang G, Yeon SH, Lee HE, Kang HC, Cho YY, Lee HS, Lee JY.
Rheumatology (Oxford). 2018 Apr 1;57(4):727-736. doi: 10.1093/rheumatology/kex499.

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats.
Yu C, He Q, Zheng J, Li LY, Hou YH, Song FZ.
Int Immunopharmacol. 2017 Apr;45:74-78. doi: 10.1016/j.intimp.2017.01.034. Epub 2017 Feb 10.

Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease.
Pennisi M, Crupi R, Di Paola R, Ontario ML, Bella R, Calabrese EJ, Crea R, Cuzzocrea S, Calabrese V.
J Neurosci Res. 2017 Jul;95(7):1360-1372. doi: 10.1002/jnr.23986. Epub 2016 Nov 8. Review.

Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway.
Dong Z, Shang H, Chen YQ, Pan LL, Bhatia M, Sun J.
Oxid Med Cell Longev. 2016;2016:7864150. Epub 2016 Oct 26.

Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome.
Lee J, Ahn H, Hong EJ, An BS, Jeung EB, Lee GS.
Cell Immunol. 2016 Aug-Sep;306-307:53-60. doi: 10.1016/j.cellimm.2016.07.007. Epub 2016 Jul 12.

A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet.
Yang G, Lee HE, Lee JY.
Sci Rep. 2016 Apr 14;6:24399. doi: 10.1038/srep24399. Erratum in: Sci Rep. 2016 May 20;6:26218. 

Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages.
An YW, Jhang KA, Woo SY, Kang JL, Chong YH.
Neurobiol Aging. 2016 Feb;38:1-10. doi: 10.1016/j.neurobiolaging.2015.10.016. Epub 2015 Oct 23.

Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism.
Greaney AJ, Maier NK, Leppla SH, Moayeri M.
J Leukoc Biol. 2016 Jan;99(1):189-99. doi: 10.1189/jlb.3A0415-155RR. Epub 2015 Aug 12.