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Adenosine Analogues (Remdesivir) and NLRP3

GEN-27 exhibits anti-inflammatory effects by suppressing the activation of NLRP3 inflammasome and NF-κB pathway.
Hu M, Li X, Zhang J, Yuan Z, Fu Y, Ma X, Ren N.
Cell Biol Int. 2019 Oct;43(10):1184-1192. doi: 10.1002/cbin.11101. Epub 2019 Aug 4.

Structural Moieties Required for Cinnamaldehyde-Related Compounds to Inhibit Canonical IL-1β Secretion.
Ho SC, Chang YH, Chang KS.
Molecules. 2018 Dec 7;23(12). pii: E3241. doi: 10.3390/molecules23123241.

P2X7 receptor inhibition attenuated sympathetic nerve sprouting after myocardial infarction via the NLRP3/IL-1β pathway.
Yin J, Wang Y, Hu H, Li X, Xue M, Cheng W, Wang Y, Li X, Yang N, Shi Y, Yan S.
J Cell Mol Med. 2017 Nov;21(11):2695-2710. doi: 10.1111/jcmm.13185. Epub 2017 May 4.

Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF-κB signaling.
Yuan C, Liu C, Wang T, He Y, Zhou Z, Dun Y, Zhao H, Ren D, Wang J, Zhang C, Yuan D.
Oncotarget. 2017 May 9;8(19):31023-31040. doi: 10.18632/oncotarget.16052.

Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives and AnalogsTargeting the NLRP3 Inflammasome.
Pan L, Hang N, Zhang C, Chen Y, Li S, Sun Y, Li Z, Meng X.
Molecules. 2017 Jan 30;22(2). pii: E213. doi: 10.3390/molecules22020213.

Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via Adenosine.
Birnbaum Y, Birnbaum GD, Birnbaum I, Nylander S, Ye Y.
Cardiovasc Drugs Ther. 2016 Dec;30(6):539-550.

Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release.
Hecker A, Küllmar M, Wilker S, Richter K, Zakrzewicz A, Atanasova S, Mathes V, Timm T, Lerner S, Klein J, Kaufmann A, Bauer S, Padberg W, Kummer W, Janciauskiene S, Fronius M, Schweda EK, Lochnit G, Grau V.
J Immunol. 2015 Sep 1;195(5):2325-34. doi: 10.4049/jimmunol.1400974. Epub 2015 Jul 22.

K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling.
Katsnelson MA, Rucker LG, Russo HM, Dubyak GR.
J Immunol. 2015 Apr 15;194(8):3937-52. doi: 10.4049/jimmunol.1402658. Epub 2015 Mar 11.

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein.
Franceschini A, Capece M, Chiozzi P, Falzoni S, Sanz JM, Sarti AC, Bonora M, Pinton P, Di Virgilio F.
FASEB J. 2015 Jun;29(6):2450-61. doi: 10.1096/fj.14-268714. Epub 2015 Feb 17.

Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.
Gicquel T, Victoni T, Fautrel A, Robert S, Gleonnec F, Guezingar M, Couillin I, Catros V, Boichot E, Lagente V.
Clin Exp Pharmacol Physiol. 2014 Apr;41(4):279-86. doi: 10.1111/1440-1681.12214.

Polyenylpyrrole derivatives inhibit NLRP3 inflammasome activation and inflammatory mediator expression by reducing reactive oxygen species production and mitogen-activated protein kinase activation.
Hua KF, Chou JC, Lam Y, Tasi YL, Chen A, Ka SM, Fang Z, Liu ML, Yang FL, Yang YL, Chiu YC, Wu SH.
PLoS One. 2013 Oct 7;8(10):e76754. doi: 10.1371/journal.pone.0076754. eCollection 2013.

P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH.
Chen S, Ma Q, Krafft PR, Hu Q, Rolland W 2nd, Sherchan P, Zhang J, Tang J, Zhang JH.
Neurobiol Dis. 2013 Oct;58:296-307. doi: 10.1016/j.nbd.2013.06.011. Epub 2013 Jun 29.

Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis.
Gulbransen BD, Bashashati M, Hirota SA, Gui X, Roberts JA, MacDonald JA, Muruve DA, McKay DM, Beck PL, Mawe GM, Thompson RJ, Sharkey KA.
Nat Med. 2012 Mar 18;18(4):600-4. doi: 10.1038/nm.2679.

Metabolic stress boosts humoral responses in vivo independently of inflammasome and inflammatory reaction.
Andris F, Denanglaire S, Baus E, Rongvaux A, Steuve J, Flavell RA, Leo O.
J Immunol. 2011 Feb 15;186(4):2245-53. doi: 10.4049/jimmunol.1002333. Epub 2011 Jan 19.