Select Page

Are You CovidMune?™

NLRP3 and SARS/Corona 

SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes.
Shi CS, Nabar NR, Huang NN, Kehrl JH.
Cell Death Discov. 2019 Jun 5;5:101. doi: 10.1038/s41420-019-0181-7. eCollection 2019.

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC.
Siu KL, Yuen KS, Castaño-Rodriguez C, Ye ZW, Yeung ML, Fung SY, Yuan S, Chan CP, Yuen KY, Enjuanes L, Jin DY.
FASEB J. 2019 Aug;33(8):8865-8877. doi: 10.1096/fj.201802418R. Epub 2019 Apr 29.

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host.
Ahn M, Anderson DE, Zhang Q, Tan CW, Lim BL, Luko K, Wen M, Chia WN, Mani S, Wang LC, Ng JHJ, Sobota RM, Dutertre CA, Ginhoux F, Shi ZL, Irving AT, Wang LF.
Nat Microbiol. 2019 May;4(5):789-799. doi: 10.1038/s41564-019-0371-3. Epub 2019 Feb 25.

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome.
Chen IY, Moriyama M, Chang MF, Ichinohe T.
Front Microbiol. 2019 Jan 29;10:50. doi: 10.3389/fmicb.2019.00050. eCollection 2019.

SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death.
Yue Y, Nabar NR, Shi CS, Kamenyeva O, Xiao X, Hwang IY, Wang M, Kehrl JH.
Cell Death Dis. 2018 Sep 5;9(9):904. doi: 10.1038/s41419-018-0917-y.

The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis.
Guo S, Yang C, Diao B, Huang X, Jin M, Chen L, Yan W, Ning Q, Zheng L, Wu Y, Chen Y.
PLoS Pathog. 2015 Sep 14;11(9):e1005155. doi: 10.1371/journal.ppat.1005155. eCollection 2015 Sep. Erratum in: PLoS Pathog. 2015 Oct;11(10):e1005216.  PLoS Pathog. 2016 Feb;12(2):e1005406

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome.
Nieto-Torres JL, Verdiá-Báguena C, Jimenez-Guardeño JM, Regla-Nava JA, Castaño-Rodriguez C, Fernandez-Delgado R, Torres J, Aguilella VM, Enjuanes L.
Virology. 2015 Nov;485:330-9. doi: 10.1016/j.virol.2015.08.010. Epub 2015 Aug 29.

Uric acid and HMGB1 are involved in the induction of autoantibodies elicited in mice infected with mouse hepatitis virus A59.
Duhalde-Vega M, Retegui LA.
Autoimmunity. 2011 Dec;44(8):631-40. doi: 10.3109/08916934.2011.579927. Epub 2011 May 23.