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Interleukin 6 (IL-6) and NLRP3

A GLP-1 Analog Liraglutide Reduces Intimal Hyperplasia After Coronary Stent Implantation viaRegulation of Glycemic Variability and NLRP3 Inflammasome/IL-10 Signaling in Diabetic Swine.
Xia J, Li Q, Liu Y, Ren Q, Gao J, Tian Y, Li J, Zhang B, Sun H, Liu S.
Front Pharmacol. 2020 Mar 26;11:372. doi: 10.3389/fphar.2020.00372. eCollection 2020.

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells.
Korhonen E, Bisevac J, Hyttinen JMT, Piippo N, Hytti M, Kaarniranta K, Petrovski G, Kauppinen A.
Invest Ophthalmol Vis Sci. 2020 Apr 9;61(4):7. doi: 10.1167/iovs.61.4.7.

Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK.
Yang J, Zhou Y, Shi J.
Life Sci. 2020 Apr 5:117645. doi: 10.1016/j.lfs.2020.117645. [Epub ahead of print]

Pien Tze Huang alleviate the joint inflammation in collagen-induced arthritis mice.
Deng Y, Luo H, Shu J, Shu H, Lu C, Zhao N, Geng Y, He X, Lu A.
Chin Med. 2020 Mar 30;15:30. doi: 10.1186/s13020-020-00311-3. eCollection 2020.

Tamarix chinensis Lour inhibits chronic ethanol-induced liver injury in mice.
Wang ZD, Zhang Y, Dai YD, Ren K, Han C, Wang HX, Yi SQ.
World J Gastroenterol. 2020 Mar 28;26(12):1286-1297. doi: 10.3748/wjg.v26.i12.1286.

Sini powder ameliorates the inflammatory response in rats with stress-induced non-alcoholic fatty liver disease by inhibiting the nuclear factor kappa-B / pyrin domain-containing protein 3 pathway.
Mu J, Cheng F, Wang Q, Wang X, Zhu W, Ma C, Yin X, Ren B, Lian Y, Du X, Zhang H, Liu S, Zhang S.
J Tradit Chin Med. 2020 Apr;40(2):253-266.

[Expression characteristics of inflammatory and apoptosis factors and regulatory effect of anemoside B4 in mice with acute kidney injury].
Li J, Zuo SS, Qiu XX, Xu X, Luo YY, Gao HW, Feng YL, DU LJ, Gong Q.
Zhongguo Zhong Yao Za Zhi. 2020 Jan;45(1):157-162. doi: 10.19540/j.cnki.cjcmm.20190918.402. Chinese. 

Fucoxanthin alleviates palmitate-induced inflammation in RAW 264.7 cells through improving lipid metabolism and attenuating mitochondrial dysfunction.
Li S, Ren X, Wang Y, Hu J, Wu H, Song S, Yan C.
Food Funct. 2020 Mar 31. doi: 10.1039/d0fo00442a. [Epub ahead of print]

Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway.
Yang K, Zhan L, Lu T, Zhou C, Chen X, Dong Y, Lv G, Chen S.
Cytokine. 2020 Mar 26;130:155058. doi: 10.1016/j.cyto.2020.155058. [Epub ahead of print]

The role of Candida albicans candidalysin ECE1 gene in oral carcinogenesis.
Nasrullah Satiman EAFE, Ahmad H, Ramzi AB, Abdul Wahab R, Kaderi MA, Harun WHAW, Dashper S, McCullough M, Arzmi MH.
J Oral Pathol Med. 2020 Mar 14. doi: 10.1111/jop.13014. [Epub ahead of print] Review.

Uric acid-mediated inflammasome activation in IL-6 primed innate immune cells is regulated by baricitinib.
Temmoku J, Fujita Y, Matsuoka N, Urano T, Furuya MY, Asano T, Sato S, Matsumoto H, Watanabe H, Kozuru H, Yatsuhashi H, Kawakami A, Migita K.
Mod Rheumatol. 2020 Mar 30:1-6. doi: 10.1080/14397595.2020.1740410. [Epub ahead of print]

Chronic acrylamide exposure induced glia cell activation, NLRP3 infl-ammasome upregulation and cognitive impairment.
Liu Y, Zhang X, Yan D, Wang Y, Wang N, Liu Y, Tan A, Chen X, Yan H.
Toxicol Appl Pharmacol. 2020 Apr 15;393:114949. doi: 10.1016/j.taap.2020.114949. Epub 2020 Mar 5.

Formononetin ameliorates myocardial ischemia/reperfusion injury in rats by suppressing the ROS-TXNIP-NLRP3 pathway.
Wang DS, Yan LY, Yang DZ, Lyu Y, Fang LH, Wang SB, Du GH.
Biochem Biophys Res Commun. 2020 May 7;525(3):759-766. doi: 10.1016/j.bbrc.2020.02.147. Epub 2020 Mar 4.

Muscone relieves inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4/JAK2-STAT3 pathway and NLRP3 inflammasome.
Yu S, Zhao G, Han F, Liang W, Jiao Y, Li Z, Li L.
Int Immunopharmacol. 2020 Mar 4;82:106355. doi: 10.1016/j.intimp.2020.106355. [Epub ahead of print]

Morin Protects LPS-Induced Mastitis via Inhibiting NLRP3 Inflammasome and NF-κB Signaling Pathways.
Yu S, Liu X, Yu D, Changyong E, Yang J.
Inflammation. 2020 Mar 5. doi: 10.1007/s10753-020-01208-x. [Epub ahead of print]

Hypervolemia-Induced Immune Disturbances Do Not Involve IL-1ß but IL-6 and IL-10 Activation in Haemodialysis Patients.
Ulrich C, Wilke A, Schleicher N, Girndt M, Fiedler R.
Toxins (Basel). 2020 Mar 3;12(3). pii: E159. doi: 10.3390/toxins12030159.

AJP001, a novel helper T-cell epitope, induces a humoral immune response with activation of innate immunity when included in a peptide vaccine.
Tenma A, Nakagami H, Tomioka H, Sakaguchi M, Ide R, Koriyama H, Hayashi H, Shimamura M, Rakugi H, Morishita R.
FASEB Bioadv. 2019 Nov 22;1(12):760-772. doi: 10.1096/fba.2019-00056. eCollection 2019 Dec.

Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells
Giridharan VV, Scaini G, Colpo GD, Doifode T, Pinjari OF, Teixeira AL, Petronilho F, Macêdo D, Quevedo J, Barichello T.
Cells. 2020 Feb 28;9(3). pii: E577. doi: 10.3390/cells9030577.

Hydrogen Sulfide Attenuates Particulate Matter-Induced Emphysema and Airway Inflammation Through Nrf2-Dependent Manner.
Jia G, Yu S, Sun W, Yang J, Wang Y, Qi Y, Chen Y.
Front Pharmacol. 2020 Feb 7;11:29. doi: 10.3389/fphar.2020.00029. eCollection 2020.

Gintonin-Enriched Fraction Suppresses Heat Stress-Induced Inflammation Through LPA Receptor.
Chei S, Song JH, Oh HJ, Lee K, Jin H, Choi SH, Nah SY, Lee BY.
Molecules. 2020 Feb 25;25(5). pii: E1019. doi: 10.3390/molecules25051019.

Silencing of KCNQ1OT1 Decreases Oxidative Stress and Pyroptosis of Renal Tubular Epithelial Cells.
Zhu B, Cheng X, Jiang Y, Cheng M, Chen L, Bao J, Tang X.
Diabetes Metab Syndr Obes. 2020 Feb 13;13:365-375. doi: 10.2147/DMSO.S225791. eCollection 2020.

Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo.
Reinke S, Linge M, Diebner HH, Luksch H, Glage S, Gocht A, Robertson AAB, Cooper MA, Hofmann SR, Naumann R, Sarov M, Behrendt R, Roers A, Pessler F, Roesler J, Rösen-Wolff A, Winkler S.
Cell Rep. 2020 Feb 25;30(8):2501-2511.e5. doi: 10.1016/j.celrep.2020.01.090.

Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome.
Tong R, Jia T, Shi R, Yan F.
Cell Mol Biol Lett. 2020 Feb 19;25:6. doi: 10.1186/s11658-020-00203-2. eCollection 2020.

Beyond IgE: Alternative Mast Cell Activation Across Different Disease States.
Lyons DO, Pullen NA.
Int J Mol Sci. 2020 Feb 22;21(4). pii: E1498. doi: 10.3390/ijms21041498. Review.

Coixol Suppresses NF-κB, MAPK Pathways and NLRP3 Inflammasome Activation in Lipopolysaccharide-Induced RAW 264.7 Cells.
Hu Y, Zhou Q, Liu T, Liu Z.
Molecules. 2020 Feb 18;25(4). pii: E894. doi: 10.3390/molecules25040894.

Atorvastatin inhibits renal inflammatory response induced by calcium oxalate crystals via inhibiting the activation of TLR4/NF-κB and NLRP3 inflammasome.
Sun Y, Liu Y, Guan X, Kang J, Wang X, Liu Q, Li D, Xu H, Tao Z, Deng Y.
IUBMB Life. 2020 May;72(5):1065-1074. doi: 10.1002/iub.2250. Epub 2020 Feb 21.

Paeoniflorin relieves LPS-induced inflammatory pain in mice by inhibiting NLRP3 inflammasome activation via transient receptor potential vanilloid 1.
Yin N, Gao Q, Tao W, Chen J, Bi J, Ding F, Wang Z.
J Leukoc Biol. 2020 Feb 21. doi: 10.1002/JLB.3MA0220-355R. [Epub ahead of print]

Calreticulin Blockade Attenuates Murine Acute Lung Injury by Inducing Polarization of M2 Subtype Macrophages.
Jiang Z, Chen Z, Hu L, Qiu L, Zhu L.
Front Immunol. 2020 Jan 30;11:11. doi: 10.3389/fimmu.2020.00011. eCollection 2020.

A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration.
Zhao Z, Wang Y, Zhou R, Li Y, Gao Y, Tu D, Wilson B, Song S, Feng J, Hong JS, Yakel JL.
J Neuroinflammation. 2020 Feb 18;17(1):64. doi: 10.1186/s12974-020-1728-5.

Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Liu B, Lu Y, Chen X, Muthuraj PG, Li X, Pattabiraman M, Zempleni J, Kachman SD, Natarajan SK, Yu J.
Nutrients. 2020 Feb 13;12(2). pii: E477. doi: 10.3390/nu12020477.

Dimethyl fumarate protects thioacetamide-induced liver damage in rats: Studies on Nrf2, NLRP3, and NF-κB.
Dwivedi DK, Jena G, Kumar V.
J Biochem Mol Toxicol. 2020 Feb 15:e22476. doi: 10.1002/jbt.22476. [Epub ahead of print]

Overexpressed FOXO3 improves inflammatory status in mice by affecting NLRP3-mediated cell coronation in necrotizing colitis mice.
Yin Y, Wang J, Zhao X, Wu X, Zou H, Qin Z, Cao J.
Biomed Pharmacother. 2020 May;125:109867. doi: 10.1016/j.biopha.2020.109867. Epub 2020 Feb 12.

GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1α-induced eosinophilic airway inflammation.
Sokulsky LA, Goggins B, Sherwin S, Eyers F, Kaiko GE, Board PG, Keely S, Yang M, Foster PS.
Clin Exp Allergy. 2020 Feb 12. doi: 10.1111/cea.13582. [Epub ahead of print]

Rhein Suppresses Lung Inflammatory Injury Induced by Human Respiratory Syncytial Virus Through Inhibiting NLRP3 Inflammasome Activation via NF-κB Pathway in Mice.
Shen C, Zhang Z, Xie T, Ji J, Xu J, Lin L, Yan J, Kang A, Dai Q, Dong Y, Shan J, Wang S, Zhao X.
Front Pharmacol. 2020 Jan 28;10:1600. doi: 10.3389/fphar.2019.01600. eCollection 2019.

Effects of irisin on osteoblast apoptosis and osteoporosis in postmenopausal osteoporosis rats through upregulating Nrf2 and inhibiting NLRP3 inflammasome.
Xu L, Shen L, Yu X, Li P, Wang Q, Li C.
Exp Ther Med. 2020 Feb;19(2):1084-1090. doi: 10.3892/etm.2019.8313. Epub 2019 Dec 10.

α-synuclein promotes progression of Parkinson’s disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome.
Wang X, Chi J, Huang D, Ding L, Zhao X, Jiang L, Yu Y, Gao F.
Exp Ther Med. 2020 Feb;19(2):931-938. doi: 10.3892/etm.2019.8297. Epub 2019 Dec 5.

Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model.
Yue J, He J, Wei Y, Shen K, Wu K, Yang X, Liu S, Zhang C, Yang H.
J Neuroinflammation. 2020 Jan 31;17(1):43. doi: 10.1186/s12974-020-1718-7.

Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis.
Saber S, Ghanim AMH, El-Ahwany E, El-Kader EMA.
Cancer Chemother Pharmacol. 2020 Feb;85(2):331-343. doi: 10.1007/s00280-020-04033-z. Epub 2020 Jan 27.

The effect of deoxyschizandrin on chronic unpredictable mild stress-induced depression.
Ma X, Zhu Z, Guo S, Duan J.
Biotechnol Appl Biochem. 2020 Jan 27. doi: 10.1002/bab.1893. [Epub ahead of print]

Antidepressant-like effects of penta-acetyl geniposide in chronic unpredictable mild stress-induced depression rat model: Involvement of inhibiting neuroinflammation in prefrontal cortex and regulating hypothalamic-pituitaryadrenal axis.
Cai L, Mu YR, Liu MM, Tang WJ, Li R.
Int Immunopharmacol. 2020 Mar;80:106182. doi: 10.1016/j.intimp.2019.106182. Epub 2020 Jan 22.

Ellagic acid protects Caco-2 cell monolayers against inflammation-induced permeabilization.
Iglesias DE, Cremonini E, Fraga CG, Oteiza PI.
Free Radic Biol Med. 2020 Jan 23. pii: S0891-5849(19)32567-5. doi: 10.1016/j.freeradbiomed.2020.01.022. [Epub ahead of print]

Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome.
Hsieh CY, Li LH, Lam Y, Fang Z, Gan CH, Rao YK, Chiu HW, Wong WT, Ju TC, Chen FH, Chernikov OV, Liu ML, Hsu CH, Hua KF.
Cells. 2020 Jan 23;9(2). pii: E279. doi: 10.3390/cells9020279.

Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.
Yang K, Lu T, Zhan L, Zhou C, Zhang N, Lei S, Wang Y, Yang J, Yan M, Lv G, Chen S.
Int J Biol Macromol. 2020 Apr 15;149:320-330. doi: 10.1016/j.ijbiomac.2020.01.026. Epub 2020 Jan 13.

Resveratrol protects human bronchial epithelial cells against nickel-induced toxicity via suppressing p38 MAPK, NF-κB signaling, and NLRP3 inflammasome activation.
Cao X, Tian S, Fu M, Li Y, Sun Y, Liu J, Liu Y.
Environ Toxicol. 2020 May;35(5):609-618. doi: 10.1002/tox.22896. Epub 2020 Jan 13.

Protective effect of Lachnum polysaccharide on dextran sulfate sodium-induced colitis in mice.
Zong S, Ye Z, Zhang X, Chen H, Ye M.
Food Funct. 2020 Jan 29;11(1):846-859. doi: 10.1039/c9fo02719j.

Aminooxyacetic acid attenuates post-infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice.
Zhao P, Zhou W, Zhang Y, Li J, Zhao Y, Pan L, Shen Z, Chen W, Hui J.
J Cell Mol Med. 2020 Feb;24(4):2593-2609. doi: 10.1111/jcmm.14972. Epub 2020 Jan 13.

Zika Virus Impairs Host NLRP3-mediated Inflammasome Activation in an NS3-dependent Manner.
Gim E, Shim DW, Hwang I, Shin OS, Yu JW.
Immune Netw. 2019 Dec 23;19(6):e40. doi: 10.4110/in.2019.19.e40. eCollection 2019 Dec.

Ghrelin alleviates traumatic brain injury-induced acute lung injury through pyroptosis/NF-κB pathway.
Shao XF, Li B, Shen J, Wang QF, Chen SS, Jiang XC, Qiang D.
Int Immunopharmacol. 2020 Feb;79:106175. doi: 10.1016/j.intimp.2019.106175. Epub 2020 Jan 6.

Contrasting effects of stored allogeneic red blood cells and their supernatants on permeability and inflammatory responses in human pulmonary endothelial cells.
Kim J, Nguyen TTT, Li Y, Zhang CO, Cha B, Ke Y, Mazzeffi MA, Tanaka KA, Birukova AA, Birukov KG.
Am J Physiol Lung Cell Mol Physiol. 2020 Mar 1;318(3):L533-L548. doi: 10.1152/ajplung.00025.2019. Epub 2020 Jan 8.

Critical role of mitochondrial oxidative stress in acid aspiration induced ALI in mice.
Puri G, Naura AS.
Toxicol Mech Methods. 2020 Jan 16:1-9. doi: 10.1080/15376516.2019.1710888. [Epub ahead of print]

The Molecular Mechanisms Associated with the Effects of Propofol in a Rat Model of Pain Due to Inflammation Following Injection with Complete Freund’s Adjuvant.
Tan S, Liu H, Wang Y, Zhu S.
Med Sci Monit. 2019 Dec 31;25:10190-10197. doi: 10.12659/MSM.918420.

[Study on regulation of NLRP3/SOCS3-TLR4-NF-κB inflammatory pathway by wogonoside to improve hepatic insulin resistance].
Zhu SL, Wu QH, Tu J.
Zhongguo Zhong Yao Za Zhi. 2019 Oct;44(20):4504-4510. doi: 10.19540/j.cnki.cjcmm.20190312.002. Chinese. 

Suppressive Effect of Huzhentongfeng on Experimental Gouty Arthritis: An In Vivo and In Vitro Study.
Wu ZC, Xue Q, Zhao ZL, Zhou PJ, Zhou Q, Zhang Z, Deng JP, Yang K, Fan H, Wang YF, Wang ZP.
Evid Based Complement Alternat Med. 2019 Dec 4;2019:2969364. doi: 10.1155/2019/2969364. eCollection 2019.

NLRP3 level in cerebrospinal fluid of patients with neuromyelitis optica spectrum disorders: Increased levels and association with disease severity.
Peng Y, Chen J, Dai Y, Jiang Y, Qiu W, Gu Y, Wang H.
Mult Scler Relat Disord. 2019 Dec 9;39:101888. doi: 10.1016/j.msard.2019.101888. [Epub ahead of print]

Circadian pharmacological effects of berberine on chronic colitis in mice: Role of the clock component Rev-erbα.
Zhou Z, Lin Y, Gao L, Yang Z, Wang S, Wu B.
Biochem Pharmacol. 2020 Feb;172:113773. doi: 10.1016/j.bcp.2019.113773. Epub 2019 Dec 20.

Exposure of DBP in gestation induces inflammation of testicular Sertoli cells in progeny by activating NLRP3 inflammasomes.
Zhou Y, Ma T, Yan M, Meng X, Wu J, Ding J, Han X, Li D.
Sci Total Environ. 2020 Mar 10;707:136139. doi: 10.1016/j.scitotenv.2019.136139. Epub 2019 Dec 15.

Eriodictyol ameliorates lipopolysaccharide-induced acute lung injury by suppressing the inflammatory COX-2/NLRP3/NF-κB pathway in mice.
Wang X, Deng R, Dong J, Huang L, Li J, Zhang B.
J Biochem Mol Toxicol. 2020 Mar;34(3):e22434. doi: 10.1002/jbt.22434. Epub 2019 Dec 20.

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3signaling pathway.
Bai Y, Li Z, Liu W, Gao D, Liu M, Zhang P.
Acta Cir Bras. 2019 Dec 20;34(11):e201901104. doi: 10.1590/s0102-865020190110000004. eCollection 2019.

lncRNA GAS5/miR-452-5p Reduces Oxidative Stress and Pyroptosis of High-Glucose-Stimulated Renal Tubular Cells.
Xie C, Wu W, Tang A, Luo N, Tan Y.
Diabetes Metab Syndr Obes. 2019 Dec 9;12:2609-2617. doi: 10.2147/DMSO.S228654. eCollection 2019.

Particulate matters induce acute exacerbation of allergic airway inflammation via the TLR2/NF-κB/NLRP3 signaling pathway.
Dai MY, Chen FF, Wang Y, Wang MZ, Lv YX, Liu RY.
Toxicol Lett. 2020 Mar 15;321:146-154. doi: 10.1016/j.toxlet.2019.12.013. Epub 2019 Dec 10.

Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Factors.
Guo Q, Li X, Cui MN, Liang Y, Li XP, Zhao J, Wei LN, Zhang XL, Quan XH.
J Ophthalmol. 2019 Nov 15;2019:9472782. doi: 10.1155/2019/9472782. eCollection 2019.

Effects of Flavonoids and Its Derivatives on Immune Cell Responses.
Martínez G, Mijares MR, De Sanctis JB.
Recent Pat Inflamm Allergy Drug Discov. 2019;13(2):84-104. doi: 10.2174/1872213X13666190426164124.

Protective effects of genipin on ethanol-induced acute gastric injury in mice by inhibiting NLRP3inflammasome activation.
Zhao T, Zhang Y, Mu S, Park JP, Bu H, Leng X, Wang S.
Eur J Pharmacol. 2020 Jan 15;867:172800. doi: 10.1016/j.ejphar.2019.172800. Epub 2019 Dec 2.

Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation.
Caution K, Young N, Robledo-Avila F, Krause K, Abu Khweek A, Hamilton K, Badr A, Vaidya A, Daily K, Gosu H, Anne MNK, Eltobgy M, Dakhlallah D, Argwal S, Estfanous
S, Zhang X, Partida-Sanchez S, Gavrilin MA, Jarjour WN, Amer AO.
Front Immunol. 2019 Nov 15;10:2519. doi: 10.3389/fimmu.2019.02519. eCollection 2019. 

Apolipoprotein M and sphingosine-1-phosphate complex alleviates TNF-α-induced endothelial cell injury and inflammation through PI3K/AKT signaling pathway.
Liu Y, Tie L.
BMC Cardiovasc Disord. 2019 Dec 2;19(1):279. doi: 10.1186/s12872-019-1263-4.

Increased inflammasome activity in markedly ill psychiatric patients: An explorative study.
Hylén U, Eklund D, Humble M, Bartoszek J, Särndahl E, Bejerot S.
J Neuroimmunol. 2020 Feb 15;339:577119. doi: 10.1016/j.jneuroim.2019.577119. Epub 2019 Nov 26.

Anti-inflammatory effect of Yam Glycoprotein on lipopolysaccharide-induced acute lung injury via the NLRP3 and NF-κB/TLR4 signaling pathway.
Niu X, Zang L, Li W, Xiao X, Yu J, Yao Q, Zhao J, Ye Z, Hu Z, Li W.
Int Immunopharmacol. 2020 Apr;81:106024. doi: 10.1016/j.intimp.2019.106024. Epub 2019 Nov 26.

Beneficial Effects of Sagacious Confucius’ Pillow Elixir on Cognitive Function in Senescence-Accelerated P8 Mice (SAMP8) via the NLRP3/Caspase-1 Pathway.
Hou Z, Li F, Chen J, Liu Y, He C, Wang M, Mei T, Zhang Y, Song L, Shao X.
Evid Based Complement Alternat Med. 2019 Nov 6;2019:3097923. doi: 10.1155/2019/3097923. eCollection 2019.

Dexamethasone alleviate allergic airway inflammation in mice by inhibiting the activation of NLRP3inflammasome.
Guan M, Ma H, Fan X, Chen X, Miao M, Wu H.
Int Immunopharmacol. 2020 Jan;78:106017. doi: 10.1016/j.intimp.2019.106017. Epub 2019 Nov 25.

Recombinant CC16 inhibits NLRP3/caspase-1-induced pyroptosis through p38 MAPK and ERK signaling pathways in the brain of a neonatal rat model with sepsis.
Zhou R, Yang X, Li X, Qu Y, Huang Q, Sun X, Mu D.
J Neuroinflammation. 2019 Nov 27;16(1):239. doi: 10.1186/s12974-019-1651-9.

Trametes orientalis polysaccharide alleviates PM2.5-induced lung injury in mice through its antioxidant and anti-inflammatory activities.
Zheng Y, Fan J, Chen HW, Liu EQ.
Food Funct. 2019 Dec 11;10(12):8005-8015. doi: 10.1039/c9fo01777a.

CD8+ T cell/adipocyte inflammatory cross talk and ensuing M1 macrophage polarization are reduced by fish-oil-derived n-3 polyunsaturated fatty acids, in part by a TNF-α-dependent mechanism.
Liddle DM, Monk JM, Hutchinson AL, Ma DWL, Robinson LE.
J Nutr Biochem. 2020 Feb;76:108243. doi: 10.1016/j.jnutbio.2019.108243. Epub 2019 Oct 24.

Qingkailing injection ameliorates cerebral ischemia-reperfusion injury and modulates the AMPK/NLRP3 Inflammasome Signalling pathway.
Ma C, Wang X, Xu T, Yu X, Zhang S, Liu S, Gao Y, Fan S, Li C, Zhai C, Cheng F, Wang Q.
BMC Complement Altern Med. 2019 Nov 20;19(1):320. doi: 10.1186/s12906-019-2703-5.

Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs.
Hu R, Wang MQ, Ni SH, Wang M, Liu LY, You HY, Wu XH, Wang YJ, Lu L, Wei LB.
Eur J Pharmacol. 2020 Jan 15;867:172797. doi: 10.1016/j.ejphar.2019.172797. Epub 2019 Nov 17.

Effect of NGR1 on the Atopic Dermatitis Model and its Mechanisms.
Wang M, Ma J.
Open Med (Wars). 2019 Nov 10;14:847-853. doi: 10.1515/med-2019-0099. eCollection 2019.

OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis.
Sánchez-Fernández A, Skouras DB, Dinarello CA, López-Vales R.
Front Immunol. 2019 Nov 1;10:2578. doi: 10.3389/fimmu.2019.02578. eCollection 2019.

Polydatin Inhibits NLRP3 Inflammasome in Dry Eye Disease by Attenuating Oxidative Stress and Inhibiting the NF-κB Pathway.
Park B, Jo K, Lee TG, Hyun SW, Kim JS, Kim CS.
Nutrients. 2019 Nov 15;11(11). pii: E2792. doi: 10.3390/nu11112792.

Methamphetamine Induces Intestinal Inflammatory Injury via Nod-Like Receptor 3 Protein (NLRP3) Inflammasome Overexpression In Vitro and In Vivo.
Zhao J, Shen S, Dai Y, Chen F, Wang K.
Med Sci Monit. 2019 Nov 12;25:8515-8526. doi: 10.12659/MSM.920190.

Morin alleviates LPS-induced mastitis by inhibiting the PI3K/AKT, MAPK, NF-κB and NLRP3 signaling pathway and protecting the integrity of blood-milk barrier.
Jiang A, Zhang Y, Zhang X, Wu D, Liu Z, Li S, Liu X, Han Z, Wang C, Wang J, Wei Z, Guo C, Yang Z.
Int Immunopharmacol. 2020 Jan;78:105972. doi: 10.1016/j.intimp.2019.105972. Epub 2019 Nov 8.

Biochanin A protects against angiotensin II-induced damage of dopaminergic neurons in rats associated with the increased endophilin A2 expression.
Xue HX, Kong H, Yu YG, Zhou JW, Chen HQ, Yin YY.
Behav Pharmacol. 2019 Dec;30(8):700-711. doi: 10.1097/FBP.0000000000000515.

Ferulic acid attenuates oxidative DNA damage and inflammatory responses in microglia induced by benzo(a)pyrene.
Bao Y, Chen Q, Xie Y, Tao Z, Jin K, Chen S, Bai Y, Yang J, Shan S.
Int Immunopharmacol. 2019 Dec;77:105980. doi: 10.1016/j.intimp.2019.105980. Epub 2019 Nov 4.

Effects of 1,25-dihydroxyvitamin D3 on experimental periodontitis and AhR/NF-κB/NLRP3inflammasome pathway in a mouse model.
Li H, Zhong X, Li W, Wang Q.
J Appl Oral Sci. 2019 Nov 4;27:e20180713. doi: 10.1590/1678-7757-2018-0713. eCollection 2019.

Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota.
Wu M, Li P, An Y, Ren J, Yan D, Cui J, Li D, Li M, Wang M, Zhong G.
Pharmacol Res. 2019 Dec;150:104489. doi: 10.1016/j.phrs.2019.104489. Epub 2019 Nov 2.

Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis.
Kang P, Wang J, Fang D, Fang T, Yu Y, Zhang W, Shen L, Li Z, Wang H, Ye H, Gao Q.
Free Radic Biol Med. 2020 Jan;146:198-210. doi: 10.1016/j.freeradbiomed.2019.10.416. Epub 2019 Nov 2.

Elevated Levels of NLRP3 in Cerebrospinal Fluid of Patients With Autoimmune GFAP Astrocytopathy.
Luo Y, Yan W, Zhou Z, Liu B, Wang Z, Chen J, Wang H.
Front Neurol. 2019 Oct 17;10:1019. doi: 10.3389/fneur.2019.01019. eCollection 2019.

Ketamine induces endoplasmic reticulum stress in rats and SV-HUC-1 human uroepithelial cells by activating NLRP3/TXNIP aix.
Cui L, Jiang X, Zhang C, Li D, Yu S, Wan F, Ma Y, Guo W, Shan Z.
Biosci Rep. 2019 Oct 30;39(10). pii: BSR20190595. doi: 10.1042/BSR20190595.

[Expression of Nod-like receptor protein 3 inflammasome in peripheral blood mononuclear cells of children with Kawasaki disease in the acute stage].
Liu LP, Yuan YH, He XH, Chen M, Peng DX, Xu W, Xia XH, Cao YD, Wang S, Zhu QL.
Zhongguo Dang Dai Er Ke Za Zhi. 2019 Oct;21(10):992-997. Chinese. 

Plasma levels of inflammatory mediators in vestibular migraine.
Karaaslan Z, Özçelik P, Ulukan Ç, Ulusoy C, Orhan KS, Orhan EK, Küçükali Cİ, Tüzün E, Baykan B, Akdal G.
Int J Neurosci. 2020 Apr;130(4):330-335. doi: 10.1080/00207454.2019.1681994. Epub 2019 Oct 24.

Exogenous Hydrogen Sulfide Alleviates-Induced Intracellular Inflammation in HepG2 Cells.
Wang YD, Li JY, Qin Y, Liu Q, Liao ZZ, Xiao XH.
Exp Clin Endocrinol Diabetes. 2020 Mar;128(3):137-143. doi: 10.1055/a-0999-0149. Epub 2019 Oct 17.

Synthesis, activity and mechanism of alkoxy-, carbamato-, sulfonamido-, thioureido-, and ureido-derivatives of 2,4,5-trimethylpyridin-3-ol against inflammatory bowel disease.
Chaudhary CL, Gurung P, Jang S, Banskota S, Nam TG, Kim JA, Jeong BS.
J Enzyme Inhib Med Chem. 2020 Dec;35(1):1-20. doi: 10.1080/14756366.2019.1677637.

Silencing of A20 Aggravates Neuronal Death and Inflammation After Traumatic Brain Injury: A Potential Trigger of Necroptosis.
Bao Z, Fan L, Zhao L, Xu X, Liu Y, Chao H, Liu N, You Y, Liu Y, Wang X, Ji J.
Front Mol Neurosci. 2019 Sep 19;12:222. doi: 10.3389/fnmol.2019.00222. eCollection 2019.

Vibrio vulnificus cytolysin induces inflammatory responses in RAW264.7 macrophages through calcium signaling and causes inflammation in vivo.
Qin K, Fu K, Liu J, Wu C, Wang Y, Zhou L
Microb Pathog. 2019 Dec;137:103789. doi: 10.1016/j.micpath.2019.103789. Epub 2019 Oct 9.

Complement C1q synergizes with PTX3 in promoting NLRP3 inflammasome over-activation and pyroptosis in rheumatoid arthritis.
Wu XY, Li KT, Yang HX, Yang B, Lu X, Zhao LD, Fei YY, Chen H, Wang L, Li J, Peng LY, Zheng WJ, Hou Y, Jiang Y, Shi Q, Zhang W, Zhang FC, Zhang JM, Huang B, He W,
Zhang X.
J Autoimmun. 2020 Jan;106:102336. doi: 10.1016/j.jaut.2019.102336. Epub 2019 Oct 7.

A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma.
Krishnan A, Kocab AJ, Zacks DN, Marshak-Rothstein A, Gregory-Ksander M.
J Neuroinflammation. 2019 Sep 30;16(1):184. doi: 10.1186/s12974-019-1576-3.

Anti-Inflammatory Effect of Cherry Extract Loaded in Polymeric Nanoparticles: Relevance of Particle Internalization in Endothelial Cells.
Beconcini D, Felice F, Zambito Y, Fabiano A, Piras AM, Macedo MH, Sarmento B, Di Stefano R.
Pharmaceutics. 2019 Sep 29;11(10). pii: E500. doi: 10.3390/pharmaceutics11100500.

Astragaloside IV attenuates gestational diabetes mellitus via targeting NLRP3 inflammasome in genetic mice.
Zhang R, Zhang X, Xing B, Zhao J, Zhang P, Shi D, Yang F.
Reprod Biol Endocrinol. 2019 Sep 26;17(1):77. doi: 10.1186/s12958-019-0522-7.

Oridonin attenuates carrageenan-induced pleurisy via activation of the KEAP-1/Nrf2 pathway and inhibition of the TXNIP/NLRP3 and NF-κB pathway in mice.
Yang H, Huang J, Gao Y, Wen Z, Peng L, Ci X.
Inflammopharmacology. 2020 Apr;28(2):513-523. doi: 10.1007/s10787-019-00644-y. Epub 2019 Sep 25.

Bruton’s Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice.
O’Riordan CE, Purvis GSD, Collotta D, Chiazza F, Wissuwa B, Al Zoubi S, Stiehler L, Martin L, Coldewey SM, Collino M, Thiemermann C.
Front Immunol. 2019 Sep 6;10:2129. doi: 10.3389/fimmu.2019.02129. eCollection 2019.

Involvement of NLRP3 and NLRC4 Inflammasome in Uropathogenic E. coli Mediated Urinary Tract Infections.
Verma V, Gupta S, Kumar P, Yadav S, Dhanda RS, Gaind R, Arora R, Frimodt-Møller N, Yadav M.
Front Microbiol. 2019 Sep 3;10:2020. doi: 10.3389/fmicb.2019.02020. eCollection 2019.

Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor.
Suzuki T, Kohyama K, Moriyama K, Ozaki M, Hasegawa S, Ueno T, Saitoe M, Morio T, Hayashi M, Sakuma H.
Eur J Immunol. 2020 Feb;50(2):205-219. doi: 10.1002/eji.201848013. Epub 2019 Oct 2.

Dexmedetomidine inhibits the NF-κB pathway and NLRP3 inflammasome to attenuate papain-induced osteoarthritis in rats.
Cheng F, Yan FF, Liu YP, Cong Y, Sun KF, He XM.
Pharm Biol. 2019 Dec;57(1):649-659. doi: 10.1080/13880209.2019.1651874.

Let-7f-5p ameliorates inflammation by targeting NLRP3 in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus.
Tan W, Gu Z, Leng J, Zou X, Chen H, Min F, Zhou W, Zhang L, Li G.
Biomed Pharmacother. 2019 Oct;118:109313. doi: 10.1016/j.biopha.2019.109313. Epub 2019 Aug 14.

Blockade of the Adenosine A3 Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1β and IL-18 in Diabetic Rats.
Garrido W, Jara C, Torres A, Suarez R, Cappelli C, Oyarzún C, Quezada C, San Martín R.
Int J Mol Sci. 2019 Sep 13;20(18). pii: E4531. doi: 10.3390/ijms20184531.

α1-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation.
Xin JZ, Wu JM, Hu GM, Gu HJ, Feng YN, Wang SX, Cong WW, Li MZ, Xu WL, Song Y, Xiao H, Zhang YY, Wang L.
Acta Pharmacol Sin. 2020 Mar;41(3):311-318. doi: 10.1038/s41401-019-0305-x. Epub 2019 Sep 17.

Protective role of p120-catenin on mitochondria by inhibiting NLRP3 in ventilator-induced lung injury.
Liu G, Gu C, Liu M, Liu H, Wang D, Liu X, Wang Y.
J Cell Mol Med. 2019 Nov;23(11):7360-7371. doi: 10.1111/jcmm.14595. Epub 2019 Sep 10.

Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway.
Wang YH, Lv HN, Cui QH, Tu PF, Jiang Y, Zeng KW.
Acta Pharmacol Sin. 2020 Feb;41(2):173-180. doi: 10.1038/s41401-019-0296-7. Epub 2019 Sep 10.

Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1β inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis.
Ridker PM, MacFadyen JG, Thuren T, Libby P.
Eur Heart J. 2019 Sep 1. pii: ehz542. doi: 10.1093/eurheartj/ehz542. [Epub ahead of print]

NLRP3 inflammasome inhibitor glyburide expedites diabetic-induced impaired fracture healing.
Yang X, Qu C, Jia J, Zhan Y.
Immunobiology. 2019 Nov;224(6):786-791. doi: 10.1016/j.imbio.2019.08.008. Epub 2019 Aug 23.

Atherothrombosis and the NLRP3 inflammasome – endogenous mechanisms of inhibition.
Satish M, Agrawal DK.
Transl Res. 2020 Jan;215:75-85. doi: 10.1016/j.trsl.2019.08.003. Epub 2019 Aug 12. Review.

Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice.
Lee HJ, Yang SJ.
Int J Mol Sci. 2019 Aug 27;20(17). pii: E4196. doi: 10.3390/ijms20174196.

Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage.
Chen B, Li H, Ou G, Ren L, Yang X, Zeng M.
Arthritis Res Ther. 2019 Aug 27;21(1):193. doi: 10.1186/s13075-019-1974-z.

NLRP3 inflammasome mediates white adipose tissue browning after burn.
Vinaik R, Barayan D, Abdullahi A, Jeschke MG.
Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E751-E759. doi: 10.1152/ajpendo.00180.2019. Epub 2019 Aug 27.

Data on microbial DNA-induced IL-1β production in monocytes of type 1 diabetes patients.
Zentsova I, Parackova Z, Kayserova J, Palova-Jelinkova L, Vrabcova P, Volfova N, Sumnik Z, Pruhova S, Petruzelkova L, Sediva A.
Data Brief. 2019 Jul 27;25:104321. doi: 10.1016/j.dib.2019.104321. eCollection 2019 Aug.

Activation of P2X7R- NLRP3 pathway in Retinal microglia contribute to Retinal Ganglion Cells death in chronic ocular hypertension (COH).
Zhang Y, Xu Y, Sun Q, Xue S, Guan H, Ji M.
Exp Eye Res. 2019 Nov;188:107771. doi: 10.1016/j.exer.2019.107771. Epub 2019 Aug 22.

Astragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1/NLRP3 inflammasome pathway.
Qian W, Cai X, Qian Q, Zhuang Q, Yang W, Zhang X, Zhao L.
Drug Des Devel Ther. 2019 Jul 29;13:2579-2589. doi: 10.2147/DDDT.S207774. eCollection 2019.

Apocynin alleviates lung injury by suppressing NLRP3 inflammasome activation and NF-κB signaling in acute pancreatitis.
Jin HZ, Yang XJ, Zhao KL, Mei FC, Zhou Y, You YD, Wang WX.
Int Immunopharmacol. 2019 Oct;75:105821. doi: 10.1016/j.intimp.2019.105821. Epub 2019 Aug 19.

Combination of schisandrin and nootkatone exerts neuroprotective effect in Alzheimer’s disease mice model.
Qi Y, Cheng X, Jing H, Yan T, Xiao F, Wu B, Bi K, Jia Y.
Metab Brain Dis. 2019 Dec;34(6):1689-1703. doi: 10.1007/s11011-019-00475-4. Epub 2019 Aug 17.

Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell.
Yao M, Fan X, Yuan B, Takagi N, Liu S, Han X, Ren J, Liu J.
BMC Complement Altern Med. 2019 Aug 14;19(1):216. doi: 10.1186/s12906-019-2615-4.

Diacerein Downregulates NLRP3/Caspase-1/IL-1β and IL-6/STAT3 Pathways of Inflammation and Apoptosis in a Rat Model of Cadmium Testicular Toxicity.
Fouad AA, Abdel-Aziz AM, Hamouda AAH.
Biol Trace Elem Res. 2019 Aug 10. doi: 10.1007/s12011-019-01865-6. [Epub ahead of print]

Kefir peptides alleviate particulate matter <4 μm (PM4.0)-induced pulmonary inflammation by inhibiting the NF-κB pathway using luciferase transgenic mice.
Chen HL, Hung KF, Yen CC, Laio CH, Wang JL, Lan YW, Chong KY, Fan HC, Chen CM.
Sci Rep. 2019 Aug 8;9(1):11529. doi: 10.1038/s41598-019-47872-4.

DPP-4 inhibition by linagliptin prevents cardiac dysfunction and inflammation by targeting the Nlrp3/ASC inflammasome.
Birnbaum Y, Tran D, Bajaj M, Ye Y.
Basic Res Cardiol. 2019 Aug 6;114(5):35. doi: 10.1007/s00395-019-0743-0.

Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota.
Sabui S, Skupsky J, Kapadia R, Cogburn K, Lambrecht NW, Agrawal A, Said HM.
Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G518-G530. doi: 10.1152/ajpgi.00172.2019. Epub 2019 Aug 1.

The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms.
Korbecki J, Bajdak-Rusinek K.
Inflamm Res. 2019 Nov;68(11):915-932. doi: 10.1007/s00011-019-01273-5. Epub 2019 Jul 30. Review.

Carthamin Yellow Protects the Heart Against Ischemia/Reperfusion Injury With Reduced Reactive Oxygen Species Release and Inflammatory Response.
Lu QY, Ma JQ, Duan YY, Sun Y, Yu S, Li B, Zhang GM.
J Cardiovasc Pharmacol. 2019 Sep;74(3):228-234. doi: 10.1097/FJC.0000000000000710.

PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway.
Mei Y, Fang C, Ding S, Liu X, Hu J, Xu J, Mei Q.
Int Immunopharmacol. 2019 Oct;75:105776. doi: 10.1016/j.intimp.2019.105776. Epub 2019 Jul 24.

Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.
Pan X, Fang X, Wang F, Li H, Niu W, Liang W, Wu C, Li J, Tu X, Pan LL, Sun J.
Br J Pharmacol. 2019 Dec;176(23):4446-4461. doi: 10.1111/bph.14806. Epub 2019 Dec 8.

Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice.
Geng J, Liu J, Yuan X, Liu W, Guo W.
Toxicol Appl Pharmacol. 2019 Sep 15;379:114688. doi: 10.1016/j.taap.2019.114688. Epub 2019 Jul 21.

High-Density Lipoproteins Decrease Proinflammatory Activity and Modulate the Innate Immune Response.
Taborda NA, Blanquiceth Y, Urcuqui-Inchima S, Latz E, Hernandez JC.
J Interferon Cytokine Res. 2019 Dec;39(12):760-770. doi: 10.1089/jir.2019.0029. Epub 2019 Jul 23.

Inhibition of Lipopolysaccharide-Induced Inflammation of Chicken Liver Tissue by Selenomethionine via TLR4-NF-κB-NLRP3 Signaling Pathway.
Qu J, Wang W, Zhang Q, Li S.
Biol Trace Elem Res. 2019 Jul 22. doi: 10.1007/s12011-019-01841-0. [Epub ahead of print]

Induction of Neuroinflammation and Neurotoxicity by Synthetic Hemozoin.
Velagapudi R, Kosoko AM, Olajide OA.
Cell Mol Neurobiol. 2019 Nov;39(8):1187-1200. doi: 10.1007/s10571-019-00713-4. Epub 2019 Jul 22.

Fraxin inhibits lipopolysaccharide-induced inflammatory cytokines and protects against endotoxic shock in mice.
Li W, Li W, Yu J, Liu F, Zang L, Xiao X, Zhao J, Yao Q, Niu X.
Fundam Clin Pharmacol. 2020 Feb;34(1):91-101. doi: 10.1111/fcp.12500. Epub 2019 Aug 28.

Suppression of Propionibacterium acnes-Induced Skin Inflammation by Laurus nobilis Extract and Its Major Constituent Eucalyptol.
Lee EH, Shin JH, Kim SS, Joo JH, Choi E, Seo SR.
Int J Mol Sci. 2019 Jul 17;20(14). pii: E3510. doi: 10.3390/ijms20143510.

AMPK as a potential pharmacological target for alleviating LPS-induced acute lung injury partly via NLRC4 inflammasome pathway inhibition.
He Y, Xu K, Wang Y, Chao X, Xu B, Wu J, Shen J, Ren W, Hu Y.
Exp Gerontol. 2019 Oct 1;125:110661. doi: 10.1016/j.exger.2019.110661. Epub 2019 Jul 15.

Anti-inflammatory Effects of Dopamine in Lipopolysaccharide (LPS)-stimulated RAW264.7 Cells via Inhibiting NLRP3 Inflammasome Activation.
Liu A, Ding S.
Ann Clin Lab Sci. 2019 May;49(3):353-360.

NLRP6 deficiency aggravates liver injury after allogeneic hematopoietic stem cell transplantation.
Li M, Chen Y, Shi J, Ju W, Qi K, Fu C, Li Z, Zhang X, Qiao J, Xu K, Zeng L.
Int Immunopharmacol. 2019 Sep;74:105740. doi: 10.1016/j.intimp.2019.105740. Epub 2019 Jul 10.

Matrine inhibits IL-1β secretion in primary porcine alveolar macrophages through the MyD88/NF-κB pathway and NLRP3 inflammasome.
Sun P, Sun N, Yin W, Sun Y, Fan K, Guo J, Khan A, He Y, Li H.
Vet Res. 2019 Jul 12;50(1):53. doi: 10.1186/s13567-019-0671-x.

Altered monocyte response to the dengue virus in those with varying severity of past dengue infection.
Kamaladasa A, Gomes L, Wijesinghe A, Jeewandara C, Toh YX, Jayathilaka D, Ogg GS, Fink K, Malavige GN.
Antiviral Res. 2019 Sep;169:104554. doi: 10.1016/j.antiviral.2019.104554. Epub 2019 Jul 6.

Anemoside B4 Protects Rat Kidney from Adenine-Induced Injury by Attenuating Inflammation and Fibrosis and Enhancing Podocin and Nephrin Expression.
Gong Q, He LL, Wang ML, Ouyang H, Gao HW, Feng YL, Yang SL, Du LJ, Li J, Luo YY.
Evid Based Complement Alternat Med. 2019 May 2;2019:8031039. doi: 10.1155/2019/8031039. eCollection 2019.

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies.
Irmscher S, Brix SR, Zipfel SLH, Halder LD, Mutlutürk S, Wulf S, Girdauskas E, Reichenspurner H, Stahl RAK, Jungnickel B, Wiech T, Zipfel PF, Skerka C.
Nat Commun. 2019 Jul 4;10(1):2961. doi: 10.1038/s41467-019-10766-0.

Elucidation of The Anti-Inflammatory Effect of Vanillin In Lps-Activated THP-1 Cells.
Zhao D, Jiang Y, Sun J, Li H, Huang M, Sun X, Zhao M.
J Food Sci. 2019 Jul;84(7):1920-1928. doi: 10.1111/1750-3841.14693. Epub 2019 Jul 2.

The effect of NLRP inflammasome on the regulation of AGEs-induced inflammatory response in human periodontal ligament cells.
Yi X, Zhang L, Lu W, Tan X, Yue J, Wang P, Xu W, Ye L, Huang D.
J Periodontal Res. 2019 Dec;54(6):681-689. doi: 10.1111/jre.12677. Epub 2019 Jun 27.

Anti-Irritant and Anti-Inflammatory Effects of DHA Encapsulated in Resveratrol-Based Solid Lipid Nanoparticles in Human Keratinocytes.
Serini S, Cassano R, Facchinetti E, Amendola G, Trombino S, Calviello G.
Nutrients. 2019 Jun 21;11(6). pii: E1400. doi: 10.3390/nu11061400.

MicroRNA-190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP-induced Parkinson’s disease mouse model.
Sun Q, Wang S, Chen J, Cai H, Huang W, Zhang Y, Wang L, Xing Y.
J Cell Physiol. 2019 Dec;234(12):23379-23387. doi: 10.1002/jcp.28907. Epub 2019 Jun 24.

Resveratrol Suppresses Aβ-Induced Microglial Activation Through the TXNIP/TRX/NLRP3 Signaling Pathway.
Feng L, Zhang L.
DNA Cell Biol. 2019 Aug;38(8):874-879. doi: 10.1089/dna.2018.4308. Epub 2019 Jun 19.

Higher CSF Levels of NLRP3 Inflammasome Is Associated With Poor Prognosis of Anti-N-methyl-D-Aspartate Receptor Encephalitis.
Peng Y, Liu B, Pei S, Zheng D, Wang Z, Ji T, Pan S, Shen HY, Wang H.
Front Immunol. 2019 May 31;10:905. doi: 10.3389/fimmu.2019.00905. eCollection 2019.

Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.
Deng G, Chen W, Wang P, Zhan T, Zheng W, Gu Z, Wang X, Ji X, Sun Y.
Int Immunopharmacol. 2019 Sep;74:105682. doi: 10.1016/j.intimp.2019.105682. Epub 2019 Jun 13.

Protective Function of Novel Fungal Immunomodulatory Proteins Fip-lti1 and Fip-lti2 from Lentinus tigrinus in Concanavalin A-Induced Liver Oxidative Injury.
Gao Y, Wáng Y, Wāng Y, Wu Y, Chen H, Yang R, Bao D.
Oxid Med Cell Longev. 2019 May 6;2019:3139689. doi: 10.1155/2019/3139689. eCollection 2019.

Inflammatory Consequences of Maternal Diabetes on the Offspring Brain: a Hippocampal Organotypic Culture Study.
Głombik K, Trojan E, Kurek A, Budziszewska B, Basta-Kaim A.
Neurotox Res. 2019 Aug;36(2):357-375. doi: 10.1007/s12640-019-00070-6. Epub 2019 Jun 13.

Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal Ischemia/Reperfusion.
Fan X, Du J, Wang MH, Li JM, Yang B, Chen Y, Dai JC, Zhang C, Zhou J.
Oxid Med Cell Longev. 2019 May 2;2019:7857082. doi: 10.1155/2019/7857082. eCollection 2019.

Extract From Plectranthus amboinicus Inhibit Maturation and Release of Interleukin 1β Through Inhibition of NF-κB Nuclear Translocation and NLRP3 Inflammasome Activation.
Leu WJ, Chen JC, Guh JH.
Front Pharmacol. 2019 May 28;10:573. doi: 10.3389/fphar.2019.00573. eCollection 2019.

Green tea polyphenols prevent lipopolysaccharide-induced inflammatory liver injury in mice by inhibiting NLRP3 inflammasome activation.
Wang D, Zhang M, Wang T, Cai M, Qian F, Sun Y, Wang Y.
Food Funct. 2019 Jul 17;10(7):3898-3908. doi: 10.1039/c9fo00572b.

Mitochondrial ROS and NLRP3 inflammasome in acute ozone-induced murine model of airway inflammation and bronchial hyperresponsiveness.
Xu M, Wang L, Wang M, Wang H, Zhang H, Chen Y, Wang X, Gong J, Zhang JJ, Adcock IM, Chung KF, Li F.
Free Radic Res. 2019 Jul;53(7):780-790. doi: 10.1080/10715762.2019.1630735. Epub 2019 Jun 27.

Datura Metel L. Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis and Inhibits Inflammatory Cytokines Production through TLR7/8-MyD88-NF-κB-NLRP3 Inflammasome Pathway.
Yang BY, Cheng YG, Liu Y, Liu Y, Tan JY, Guan W, Guo S, Kuang HX.
Molecules. 2019 Jun 7;24(11). pii: E2157. doi: 10.3390/molecules24112157.

Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis.
Tavakoli Dargani Z, Singla DK.
Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H460-H471. doi: 10.1152/ajpheart.00056.2019. Epub 2019 Jun 7.

HMGB1/RAGE pro-inflammatory axis promotes vascular endothelial cell apoptosis in limb ischemia/reperfusion injury.
Mi L, Zhang Y, Xu Y, Zheng X, Zhang X, Wang Z, Xue M, Jin X.
Biomed Pharmacother. 2019 Aug;116:109005. doi: 10.1016/j.biopha.2019.109005. Epub 2019 May 25.

Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.
Lin Y, Wang S, Yang Z, Gao L, Zhou Z, Yu P, Wu B.
Biomed Pharmacother. 2019 Aug;116:108973. doi: 10.1016/j.biopha.2019.108973. Epub 2019 May 20.

Rhynchophylline Attenuates Neurotoxicity in Tourette Syndrome Rats.
Hongyan L, Mengjiao Z, Chunyan W, Yaruo H.
Neurotox Res. 2019 Nov;36(4):679-687. doi: 10.1007/s12640-019-00059-1. Epub 2019 May 21.

P2X7 Receptor Expression in Patients With Serositis Related to Systemic Lupus Erythematosus.
Furini F, Giuliani AL, Parlati ME, Govoni M, Di Virgilio F, Bortoluzzi A.
Front Pharmacol. 2019 Apr 29;10:435. doi: 10.3389/fphar.2019.00435. eCollection 2019.

TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice.
Wang Z, Zhou L, An D, Xu W, Wu C, Sha S, Li Y, Zhu Y, Chen A, Du Y, Chen L, Chen L.
Cell Death Dis. 2019 May 16;10(6):386. doi: 10.1038/s41419-019-1612-3. Erratum in: Cell Death Dis. 2019 Jun 21;10(7):491

Puerarin inhibits vascular calcification of uremic rats.
Liu H, Zhang X, Zhong X, Li Z, Cai S, Yang P, Ou C, Chen M.
Eur J Pharmacol. 2019 Jul 15;855:235-243. doi: 10.1016/j.ejphar.2019.05.023. Epub 2019 May 11. 

Pharmacological basis for use of madecassoside in gouty arthritis: anti-inflammatory, anti-hyperuricemic, and NLRP3 inhibition.
Lu X, Zeng R, Lin J, Hu J, Rong Z, Xu W, Liu Z, Zeng W.
Immunopharmacol Immunotoxicol. 2019 Apr;41(2):277-284. doi: 10.1080/08923973.2019.1590721. Epub 2019 May 14.

Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine.
Gong W, Zhang S, Zong Y, Halim M, Ren Z, Wang Y, Ma Y, Li B, Ma L, Zhou G, Yu J, Zhang J, Liu Q.
J Affect Disord. 2019 Jul 1;254:15-25. doi: 10.1016/j.jad.2019.05.009. Epub 2019 May 5.

Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation.
Ge C, Xu M, Qin Y, Gu T, Lou D, Li Q, Hu L, Nie X, Wang M, Tan J.
Food Funct. 2019 May 22;10(5):2970-2985. doi: 10.1039/c8fo01653d.

Role of microglial activation and neuroinflammation in neurotoxicity of acrylamide in vivo and in vitro.
Zong C, Hasegawa R, Urushitani M, Zhang L, Nagashima D, Sakurai T, Ichihara S, Ohsako S, Ichihara G.
Arch Toxicol. 2019 Jul;93(7):2007-2019. doi: 10.1007/s00204-019-02471-0. Epub 2019 May 9.

AT-533, a Hsp90 inhibitor, attenuates HSV-1-induced inflammation.
Li F, Song X, Su G, Wang Y, Wang Z, Qing S, Jia J, Wang Y, Huang L, Zheng K, Wang Y.
Biochem Pharmacol. 2019 Aug;166:82-92. doi: 10.1016/j.bcp.2019.05.003. Epub 2019 May 6.

FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation.
Yao S, Li L, Sun X, Hua J, Zhang K, Hao L, Liu L, Shi D, Zhou H.
J Neuroimmune Pharmacol. 2019 Sep;14(3):478-492. doi: 10.1007/s11481-019-09843-4. Epub 2019 May 8.

Lactobacillus rhamnosus GG Ameliorates Liver Injury and Hypoxic Hepatitis in Rat Model of CLP-Induced Sepsis.
Ding L, Gong Y, Yang Z, Zou B, Liu X, Zhang B, Li J.
Dig Dis Sci. 2019 Oct;64(10):2867-2877. doi: 10.1007/s10620-019-05628-0. Epub 2019 Apr 30.

[The Effect of Interference of NLRP3 with shRNA on AGEs-induced Inflammatory Response in Myocardial Cell].
Jia HL, Lu CQ, Wang J, Ren DD, Chen YQ.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 Jan;50(1):7-12. Chinese. 

Olive Leaf Extract (OleaVita) Suppresses Inflammatory Cytokine Production and NLRP3Inflammasomes in Human Placenta.
Kaneko Y, Sano M, Seno K, Oogaki Y, Takahashi H, Ohkuchi A, Yokozawa M, Yamauchi K, Iwata H, Kuwayama T, Shirasuna K.
Nutrients. 2019 Apr 28;11(5). pii: E970. doi: 10.3390/nu11050970.

Atractylodin ameliorates lipopolysaccharide and d-galactosamine-induced acute liver failure via the suppression of inflammation and oxidative stress.
Lyu Z, Ji X, Chen G, An B.
Int Immunopharmacol. 2019 Jul;72:348-357. doi: 10.1016/j.intimp.2019.04.005. Epub 2019 Apr 24.

Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome.
Qin M, Long F, Wu W, Yang D, Huang M, Xiao C, Chen X, Liu X, Zhu YZ.
Free Radic Biol Med. 2019 Jun;137:99-109. doi: 10.1016/j.freeradbiomed.2019.04.025. Epub 2019 Apr 23.

PPAR-γ Activation Exerts an Anti-inflammatory Effect by Suppressing the NLRP3 Inflammasome in Spinal Cord-Derived Neurons.
Meng QQ, Feng ZC, Zhang XL, Hu LQ, Wang M, Zhang HF, Li SM.
Mediators Inflamm. 2019 Mar 13;2019:6386729. doi: 10.1155/2019/6386729. eCollection 2019.

Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3inflammasome in macrophages.
Hung YL, Wang SC, Suzuki K, Fang SH, Chen CS, Cheng WC, Su CC, Yeh HC, Tu HP, Liu PL, Huang MY, Li CY.
Phytomedicine. 2019 Jun;59:152785. doi: 10.1016/j.phymed.2018.12.008. Epub 2018 Dec 10.

3D type I collagen environment leads up to a reassessment of the classification of human macrophage polarizations.
Court M, Malier M, Millet A.
Biomaterials. 2019 Jul;208:98-109. doi: 10.1016/j.biomaterials.2019.04.018. Epub 2019 Apr 13.

Circulating Peroxiredoxin-1 is a novel damage-associated molecular pattern and aggravates acute liver injury via promoting inflammation.
He Y, Li S, Tang D, Peng Y, Meng J, Peng S, Deng Z, Qiu S, Liao X, Chen H, Tu S, Tao L, Peng Z, Yang H.
Free Radic Biol Med. 2019 Jun;137:24-36. doi: 10.1016/j.freeradbiomed.2019.04.012. Epub 2019 Apr 13.

Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics.
Thangaraj A, Periyasamy P, Guo ML, Chivero ET, Callen S, Buch S.
Autophagy. 2020 Feb;16(2):289-312. doi: 10.1080/15548627.2019.1607686. Epub 2019 Apr 28.

[Effect of ethanolic extract of Polygonum cuspidatum on acute gouty arthritis in mice through NLRP3/ASC/caspase-1 axis].
Ma TH, Sheng T, Tian CM, Xing MY, Yan LJ, Xia DZ.
Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(3):546-552. doi: 10.19540/j.cnki.cjcmm.20180925.001. Chinese. 

Exploring the Involvement of NLRP3 and IL-1β in Osteoarthritis of the Hand: Results from a Pilot Study.
Fioravanti A, Tenti S, McAllister M, Chemaly M, Eakin A, McLaughlin J, Bjourson AJ, Frati E, McGilligan V, Cheleschi S, Gibson DS.
Mediators Inflamm. 2019 Mar 10;2019:2363460. doi: 10.1155/2019/2363460. eCollection 2019.

MCC950 blocks enhanced interleukin-1β production in patients with NLRP3 low penetrance variants.
Schuh E, Groß CJ, Wagner D, Schlüter M, Groß O, Kümpfel T.
Clin Immunol. 2019 Jun;203:45-52. doi: 10.1016/j.clim.2019.04.004. Epub 2019 Apr 8.

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.
Han X, Sun S, Sun Y, Song Q, Zhu J, Song N, Chen M, Sun T, Xia M, Ding J, Lu M, Yao H, Hu G.
Autophagy. 2019 Nov;15(11):1860-1881. doi: 10.1080/15548627.2019.1596481. Epub 2019 Apr 9.

Therapeutic effect of dexmedetomidine on intracerebral hemorrhage via regulating NLRP3.
Song HL, Zhang SB.
Eur Rev Med Pharmacol Sci. 2019 Mar;23(6):2612-2619. doi: 10.26355/eurrev_201903_17411.

Treatment of lidocaine on subacute thyroiditis via restraining inflammatory factor expression and inhibiting pyroptosis pathway.
Yang X, Yang LX, Wu J, Guo ML, Zhang Y, Ma SG.
J Cell Biochem. 2019 Apr 8. doi: 10.1002/jcb.27675. [Epub ahead of print]

Rhein protects against barrier disruption and inhibits inflammation in intestinal epithelial cells.
Zhuang S, Zhong J, Zhou Q, Zhong Y, Liu P, Liu Z.
Int Immunopharmacol. 2019 Jun;71:321-327. doi: 10.1016/j.intimp.2019.03.030. Epub 2019 Apr 2.

Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome.
Chiu HW, Li LH, Hsieh CY, Rao YK, Chen FH, Chen A, Ka SM, Hua KF.
Sci Rep. 2019 Apr 3;9(1):5603. doi: 10.1038/s41598-019-42130-z.

Protective effects of propofol on experimental neonatal acute lung injury.
Yu X, Li C.
Mol Med Rep. 2019 May;19(5):4507-4513. doi: 10.3892/mmr.2019.10113. Epub 2019 Apr 1.

Effects of α-lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation.
Kim SM, Ha JS, Han AR, Cho SW, Yang SJ.
BMB Rep. 2019 Oct;52(10):613-618.

Oral Ketone Supplementation Acutely Increases Markers of NLRP3 Inflammasome Activation in Human Monocytes.
Neudorf H, Durrer C, Myette-Cote E, Makins C, O’Malley T, Little JP.
Mol Nutr Food Res. 2019 Jun;63(11):e1801171. doi: 10.1002/mnfr.201801171. Epub 2019 Apr 5.

Antidepressant-like Effects Induced by Chronic Blockade of the Purinergic 2X7 Receptor through Inhibition of Non-like Receptor Protein 1 Inflammasome in Chronic Unpredictable Mild Stress Model of Depression in Rats.
Aricioglu F, Ozkartal CS, Bastaskin T, Tüzün E, Kandemir C, Sirvanci S, Kucukali CI, Utkan T.
Clin Psychopharmacol Neurosci. 2019 May 31;17(2):261-272. doi: 10.9758/cpn.2019.17.2.261.

The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation.
Peng XP, Li XH, Li Y, Huang XT, Luo ZQ.
Int Immunopharmacol. 2019 May;70:520-529. doi: 10.1016/j.intimp.2019.03.018. Epub 2019 Mar 19.

Inflammatory status and severity of disease in dengue patients are associated with lipoprotein alterations.
Marin-Palma D, Sirois CM, Urcuqui-Inchima S, Hernandez JC.
PLoS One. 2019 Mar 22;14(3):e0214245. doi: 10.1371/journal.pone.0214245. eCollection 2019.

Dihydromyricetin Alleviates Sepsis-Induced Acute Lung Injury through Inhibiting NLRP3Inflammasome-Dependent Pyroptosis in Mice Model.
Wang YC, Liu QX, Zheng Q, Liu T, Xu XE, Liu XH, Gao W, Bai XJ, Li ZF.
Inflammation. 2019 Aug;42(4):1301-1310. doi: 10.1007/s10753-019-00990-7.

Activation of Nicotinic Acetylcholine α7 Receptor Attenuates Progression of Monocrotaline-Induced Pulmonary Hypertension in Rats by Downregulating the NLRP3 Inflammasome.
Deng Y, Guo SL, Wei B, Gao XC, Zhou YC, Li JQ.
Front Pharmacol. 2019 Feb 26;10:128. doi: 10.3389/fphar.2019.00128. eCollection 2019.

New Insights into the Mechanisms of Action of Topical Administration of GLP-1 in an Experimental Model of Diabetic Retinopathy.
Sampedro J, Bogdanov P, Ramos H, Solà-Adell C, Turch M, Valeri M, Simó-Servat O, Lagunas C, Simó R, Hernández C.
J Clin Med. 2019 Mar 11;8(3). pii: E339. doi: 10.3390/jcm8030339.

The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages.
Finucane OM, Sugrue J, Rubio-Araiz A, Guillot-Sestier MV, Lynch MA.
Sci Rep. 2019 Mar 11;9(1):4034. doi: 10.1038/s41598-019-40619-1.

Isorhynchophylline exerts anti-inflammatory and anti-oxidative activities in LPS-stimulated murine alveolar macrophages.
Zhou Z, Su Y, Fa XE.
Life Sci. 2019 Apr 15;223:137-145. doi: 10.1016/j.lfs.2019.03.017. Epub 2019 Mar 8.

Lupeol inhibits LPS-induced neuroinflammation in cerebellar cultures and induces neuroprotection associated to the modulation of astrocyte response and expression of neurotrophic and inflammatory factors.
Oliveira-Junior MS, Pereira EP, de Amorim VCM, Reis LTC, do Nascimento RP, da Silva VDA, Costa SL.
Int Immunopharmacol. 2019 May;70:302-312. doi: 10.1016/j.intimp.2019.02.055. Epub 2019 Mar 7.

Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritis fibroblast-like synoviocytes and rheumatoid arthritis progression in mice.
Chen J, Wu W, Zhang M, Chen C.
Int Immunopharmacol. 2019 May;70:274-283. doi: 10.1016/j.intimp.2019.02.029. Epub 2019 Mar 6.

Catheter-based renal sympathetic denervation induces acute renal inflammation through activation of caspase-1 and NLRP3 inflammasome.
Lee DW, Kim JS, Kim IY, Kim HS, Kim JY, Rhee H, Seong EY, Song SH, Lee SB, Edelstein CL, Kwak IS.
Anatol J Cardiol. 2019 Mar;21(3):134-141. doi: 10.14744/AnatolJCardiol.2018.62257.

Novel Antiatherosclerotic Therapies.
Libby P, Everett BM.
Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):538-545. doi: 10.1161/ATVBAHA.118.310958. Review.

Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats.
Cinar I, Sirin B, Aydin P, Toktay E, Cadirci E, Halici I, Halici Z.
Life Sci. 2019 Mar 15;221:327-334. doi: 10.1016/j.lfs.2019.02.039. Epub 2019 Feb 20.

Polydatin alleviates traumatic spinal cord injury by reducing microglial inflammation via regulation of iNOS and NLRP3 inflammasome pathway.
Lv R, Du L, Liu X, Zhou F, Zhang Z, Zhang L.
Int Immunopharmacol. 2019 May;70:28-36. doi: 10.1016/j.intimp.2019.02.006. Epub 2019 Feb 19.

Necrotic cell debris induces a NF-κB-driven inflammasome response in vascular smooth muscle cells derived from abdominal aortic aneurysms (AAA-SMC).
Wortmann M, Skorubskaya E, Peters AS, Hakimi M, Böckler D, Dihlmann S.
Biochem Biophys Res Commun. 2019 Apr 2;511(2):343-349. doi: 10.1016/j.bbrc.2019.02.051. Epub 2019 Feb 16.

Ammonia exposure induced abnormal expression of cytokines and heat shock proteins via glucose metabolism disorders in chicken neutrophils.
Wang D, Zhang Y, Chi Q, Hu X, Li S, Li S.
Environ Sci Pollut Res Int. 2019 Apr;26(11):10529-10536. doi: 10.1007/s11356-019-04516-4. Epub 2019 Feb 14.

Suppressive effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice.
Wu X, Tang B, Liao X, Su Z, Lee SM, Cai Y, Li C.
Food Funct. 2019 Feb 20;10(2):1212-1224. doi: 10.1039/c8fo02474j.

Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression.
Cleophas MCP, Crişan TO, Klück V, Hoogerbrugge N, Netea-Maier RT, Dinarello CA, Netea MG, Joosten LAB.
Arthritis Res Ther. 2019 Feb 6;21(1):50. doi: 10.1186/s13075-019-1834-x.

MCC950 attenuated early brain injury by suppressing NLRP3 inflammasome after experimental SAH in rats.
Luo Y, Lu J, Ruan W, Guo X, Chen S.
Brain Res Bull. 2019 Mar;146:320-326. doi: 10.1016/j.brainresbull.2019.01.027. Epub 2019 Feb 1.

NLRP6 suppresses the inflammatory response of human periodontal ligament cells by inhibiting NF-κB and ERK signal pathways.
Lu WL, Zhang L, Song DZ, Yi XW, Xu WZ, Ye L, Huang DM.
Int Endod J. 2019 Jul;52(7):999-1009. doi: 10.1111/iej.13091. Epub 2019 Mar 5.

Anticytokine Agents: Targeting Interleukin Signaling Pathways for the Treatment of Atherothrombosis
Ridker PM.
Circ Res. 2019 Feb;124(3):437-450. doi: 10.1161/CIRCRESAHA.118.313129. Review.

The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Xia Y, Liu N, Xie X, Bi G, Ba H, Li L, Zhang J, Deng X, Yao Y, Tang Z, Yin B, Wang J, Jiang K, Li Z, Choi Y, Gong F, Cheng X, O’Shea JJ, Chae JJ, Laurence A, Yang XP.
Autophagy. 2019 Jun;15(6):960-975. doi: 10.1080/15548627.2019.1569916. Epub 2019 Jan 29.

Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.
Chen YS, Chen QZ, Wang ZJ, Hua C.
Pharmacology. 2019;103(3-4):143-150. doi: 10.1159/000493896. Epub 2019 Jan 23.

Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome.
Du Y, Gu X, Meng H, Aa N, Liu S, Peng C, Ge Y, Yang Z.
Am J Transl Res. 2018 Dec 15;10(12):4235-4246. eCollection 2018.

Chronic unpredictable mild stress accelerates lipopolysaccharide- induced microglia activation and damage of dopaminergic neurons in rats.
Kong H, Yang L, He C, Zhou JW, Li WZ, Wu WN, Chen HQ, Yin YY.
Pharmacol Biochem Behav. 2019 Apr;179:142-149. doi: 10.1016/j.pbb.2019.01.004. Epub 2019 Jan 16.

GEN-27 exhibits anti-inflammatory effects by suppressing the activation of NLRP3 inflammasome and NF-κB pathway.
Hu M, Li X, Zhang J, Yuan Z, Fu Y, Ma X, Ren N.
Cell Biol Int. 2019 Oct;43(10):1184-1192. doi: 10.1002/cbin.11101. Epub 2019 Aug 4.

Acacetin protects against cerebral ischemia-reperfusion injury via the NLRP3 signaling pathway.
Bu J, Shi S, Wang HQ, Niu XS, Zhao ZF, Wu WD, Zhang XL, Ma Z, Zhang YJ, Zhang H, Zhu Y.
Neural Regen Res. 2019 Apr;14(4):605-612. doi: 10.4103/1673-5374.247465.

miRNA-20b inhibits cerebral ischemia-induced inflammation through targeting NLRP3.
Zhao J, Wang H, Dong L, Sun S, Li L.
Int J Mol Med. 2019 Mar;43(3):1167-1178. doi: 10.3892/ijmm.2018.4043. Epub 2018 Dec 31.

Apoptosis signal-regulating kinase-1 promotes inflammasome priming in macrophages.
Immanuel CN, Teng B, Dong B, Gordon EM, Kennedy JA, Luellen C, Schwingshackl A, Cormier SA, Fitzpatrick EA, Waters CM.
Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L418-L427. doi: 10.1152/ajplung.00199.2018. Epub 2019 Jan 10.

SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury.
Kurundkar D, Kurundkar AR, Bone NB, Becker EJ Jr, Liu W, Chacko B, Darley-Usmar V, Zmijewski JW, Thannickal VJ.
JCI Insight. 2019 Jan 10;4(1). pii: 120722. doi: 10.1172/jci.insight.120722. [Epub ahead of print]

Purification and Characterization of a Novel Pentadecapeptide from Protein Hydrolysates of Cyclina sinensis and Its Immunomodulatory Effects on RAW264.7 Cells.
Li W, Ye S, Zhang Z, Tang J, Jin H, Huang F, Yang Z, Tang Y, Chen Y, Ding G, Yu F.
Mar Drugs. 2019 Jan 6;17(1). pii: E30. doi: 10.3390/md17010030.

Protective Effect of Anthocyanin on Neurovascular Unit in Cerebral Ischemia/Reperfusion Injury in Rats.
Pan Z, Cui M, Dai G, Yuan T, Li Y, Ji T, Pan Y.
Front Neurosci. 2018 Dec 11;12:947. doi: 10.3389/fnins.2018.00947. eCollection 2018.

Increased neutrophil extracellular traps activate NLRP3 and inflammatory macrophages in adult-onset Still’s disease.
Hu Q, Shi H, Zeng T, Liu H, Su Y, Cheng X, Ye J, Yin Y, Liu M, Zheng H, Wu X, Chi H, Zhou Z, Jia J, Sun Y, Teng J, Yang C.
Arthritis Res Ther. 2019 Jan 7;21(1):9. doi: 10.1186/s13075-018-1800-z.

Metabolic syndrome mediates proinflammatory responses of inflammatory cells in preeclampsia.
Jabalie G, Ahmadi M, Koushaeian L, Eghbal-Fard S, Mehdizadeh A, Kamrani A, Abdollahi-Fard S, Farzadi L, Hojjat-Farsangi M, Nouri M, Yousefi M.
Am J Reprod Immunol. 2019 Mar;81(3):e13086. doi: 10.1111/aji.13086. Epub 2019 Feb 5.

Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3/IL-1β and promoting Nrf2/HO-1.
Song S, An J, Li Y, Liu S.
Mol Immunol. 2019 Feb;106:143-152. doi: 10.1016/j.molimm.2018.12.023. Epub 2019 Jan 2.

Protective effects of sulforaphane on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of NLRP3 inflammasome formation.
Li S, Yang H, Chen X.
Exp Anim. 2019 May 8;68(2):221-231. doi: 10.1538/expanim.18-0146. Epub 2019 Jan 1.

MiR-24 inhibits inflammatory responses in LPS-induced acute lung injury of neonatal rats through targeting NLRP3.
Lin Y, Yang Y.
Pathol Res Pract. 2019 Apr;215(4):683-688. doi: 10.1016/j.prp.2018.12.028. Epub 2018 Dec 26.

Amygdalin attenuates acute liver injury induced by D-galactosamine and lipopolysaccharide by regulating the NLRP3, NF-κB and Nrf2/NQO1 signalling pathways.
Tang F, Fan K, Wang K, Bian C.
Biomed Pharmacother. 2019 Mar;111:527-536. doi: 10.1016/j.biopha.2018.12.096. Epub 2018 Dec 28.

Protein kinase D mediates inflammatory responses of human placental macrophages to Group B Streptococcus.
Sutton JA, Rogers LM, Dixon BREA, Kirk L, Doster R, Algood HM, Gaddy JA, Flaherty R, Manning SD, Aronoff DM.
Am J Reprod Immunol. 2019 Mar;81(3):e13075. doi: 10.1111/aji.13075. Epub 2019 Jan 30.

Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome.
Shen P, Zhang Z, Zhu K, Cao H, Liu J, Lu X, Li Y, Jing Y, Yuan X, Fu Y, Cao Y, Zhang N.
Biomed Pharmacother. 2019 Feb;110:786-795. doi: 10.1016/j.biopha.2018.12.033. Epub 2018 Dec 13.

Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.
Zhang WY, Guo YJ, Han WX, Yang MQ, Wen LP, Wang KY, Jiang P.
Int Immunopharmacol. 2019 Feb;67:138-144. doi: 10.1016/j.intimp.2018.12.012. Epub 2018 Dec 11.

Imoxin attenuates LPS-induced inflammation and MuRF1 expression in mouse skeletal muscle.
Valentine RJ, Jefferson MA, Kohut ML, Eo H.
Physiol Rep. 2018 Dec;6(23):e13941. doi: 10.14814/phy2.13941.

Unraveling the Novel Protective Effect of Patchouli Alcohol Against Helicobacter pylori-Induced Gastritis: Insights Into the Molecular Mechanism in vitro and in vivo.
Lian DW, Xu YF, Ren WK, Fu LJ, Chen FJ, Tang LY, Zhuang HL, Cao HY, Huang P.
Front Pharmacol. 2018 Nov 22;9:1347. doi: 10.3389/fphar.2018.01347. eCollection 2018.

Suppression of miR-21 and miR-155 of macrophage by cinnamaldehyde ameliorates ulcerative colitis.
Qu S, Shen Y, Wang M, Wang X, Yang Y.
Int Immunopharmacol. 2019 Feb;67:22-34. doi: 10.1016/j.intimp.2018.11.045. Epub 2018 Dec 6.

Fraxin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting the NF-κB and NLRP3 signalling pathways.
Li W, Li W, Zang L, Liu F, Yao Q, Zhao J, Zhi W, Niu X.
Int Immunopharmacol. 2019 Feb;67:1-12. doi: 10.1016/j.intimp.2018.12.003. Epub 2018 Dec 6.

Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acute liver failure by reducing the activity of the NLRP3 inflammasome in macrophages.
Jiang L, Zhang S, Hu H, Yang J, Wang X, Ma Y, Jiang J, Wang J, Zhong L, Chen M, Wang H, Hou Y, Zhu R, Zhang Q.
Biochem Biophys Res Commun. 2019 Jan 15;508(3):735-741. doi: 10.1016/j.bbrc.2018.11.189. Epub 2018 Dec 6.

Sodium Phenylbutyrate Ameliorates Inflammatory Response Induced by Staphylococcus aureusLipoteichoic Acid via Suppressing TLR2/NF-κB/NLRP3 Pathways in MAC-T Cells.
Wang X, Zhang M, Jiang N, Zhang A.
Molecules. 2018 Nov 22;23(12). pii: E3056. doi: 10.3390/molecules23123056.

Salvianolate reduces atrial fibrillation through suppressing atrial interstitial fibrosis by inhibiting TGF-β1/Smad2/3 and TXNIP/NLRP3 inflammasome signaling pathways in post-MI rats.
Qiu H, Liu W, Lan T, Pan W, Chen X, Wu H, Xu D.
Phytomedicine. 2018 Dec 1;51:255-265. doi: 10.1016/j.phymed.2018.09.238. Epub 2018 Oct 4.

Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozone-induced lung inflammation and emphysema.
Li F, Xu M, Wang M, Wang L, Wang H, Zhang H, Chen Y, Gong J, Zhang JJ, Adcock IM, Chung KF, Zhou X.
Respir Res. 2018 Nov 22;19(1):230. doi: 10.1186/s12931-018-0931-8.

Anti-Inflammatory Activity of Lobaric Acid via Suppressing NF-κB/MAPK Pathways or NLRP3Inflammasome Activation.
Lee HW, Kim J, Yim JH, Lee HK, Pyo S.
Planta Med. 2019 Mar;85(4):302-311. doi: 10.1055/a-0777-2420. Epub 2018 Nov 16.

Ethanol upregulates the P2X7 purinergic receptor in human macrophages.
Le Daré B, Victoni T, Bodin A, Vlach M, Vene E, Loyer P, Lagente V, Gicquel T.
Fundam Clin Pharmacol. 2019 Feb;33(1):63-74. doi: 10.1111/fcp.12433. Epub 2018 Dec 3.

Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming.
Hoyle C, Rivers-Auty J, Lemarchand E, Vranic S, Wang E, Buggio M, Rothwell NJ, Allan SM, Kostarelos K, Brough D.
ACS Nano. 2018 Dec 26;12(12):11949-11962. doi: 10.1021/acsnano.8b03642. Epub 2018 Nov 20.

1,25-Dihydroxy Vitamin D3 Attenuates the Oxidative Stress-Mediated Inflammation Induced by PM2.5via the p38/NF-κB/NLRP3 Pathway.
Xin L, Che B, Zhai B, Luo Q, Zhang C, Wang J, Wang S, Fan G, Liu Z, Feng J, Zhang Z.
Inflammation. 2019 Apr;42(2):702-713. doi: 10.1007/s10753-018-0928-y.

Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma.
Harun-Or-Rashid M, Inman DM.
J Neuroinflammation. 2018 Nov 13;15(1):313. doi: 10.1186/s12974-018-1346-7.

Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness.
Xu M, Li F, Wang M, Zhang H, Xu L, Adcock IM, Chung KF, Zhang Y.
Eur J Pharmacol. 2019 Jan 5;842:373-383. doi: 10.1016/j.ejphar.2018.11.010. Epub 2018 Nov 9.

Regulation of host cell pyroptosis and cytokines production by Mycobacterium tuberculosis effector PPE60 requires LUBAC mediated NF-κB signaling.
Gong Z, Kuang Z, Li H, Li C, Ali MK, Huang F, Li P, Li Q, Huang X, Ren S, Li J, Xie J.
Cell Immunol. 2019 Jan;335:41-50. doi: 10.1016/j.cellimm.2018.10.009. Epub 2018 Oct 30.

Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation.
Gomez-Lopez N, Romero R, Maymon E, Kusanovic JP, Panaitescu B, Miller D, Pacora P, Tarca AL, Motomura K, Erez O, Jung E, Hassan SS, Hsu CD.
J Perinat Med. 2019 Apr 24;47(3):276-287. doi: 10.1515/jpm-2018-0271.

Anti-inflammatory effect of Resolvin D1 on LPS-treated MG-63 cells.
Cao D, Pi J, Shan Y, Tang Y, Zhou P.
Exp Ther Med. 2018 Nov;16(5):4283-4288. doi: 10.3892/etm.2018.6721. Epub 2018 Sep 11. Erratum in: Exp Ther Med. 2019 Nov;18(5):4173

Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1β production.
Gong Z, Zhao S, Zhou J, Yan J, Wang L, Du X, Li H, Chen Y, Cai W, Wu J.
Mol Immunol. 2018 Dec;104:11-19. doi: 10.1016/j.molimm.2018.09.004. Epub 2018 Nov 3.

Ω-3 fatty acids-supplementary in gestation alleviates neuroinflammation and modulates neurochemistry in rats.
Tang M, Dang R, Liu S, Zhang M, Zheng Y, Yang R, Yin T.
Lipids Health Dis. 2018 Nov 3;17(1):247. doi: 10.1186/s12944-018-0894-2.

[Alpha-lipoamide inhibits renal inflammation and collagen 4 production in diabetic rats and its mechanism].Peng C, Jiang X, Xiao Y, Yuan Z, Mao Y, Wang Wang Y, Zhang Y, Zhang F, Tang L, Guo B
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018 Jul;34(7):617-622. Chinese. 

Mechanistic insight into the attenuation of gouty inflammation by Taiwanese green propolis via inhibition of the NLRP3 inflammasome.
Hsieh CY, Li LH, Rao YK, Ju TC, Nai YS, Chen YW, Hua KF.
J Cell Physiol. 2019 Apr;234(4):4081-4094. doi: 10.1002/jcp.27204. Epub 2018 Oct 28.

Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression.
Lowe PP, Gyongyosi B, Satishchandran A, Iracheta-Vellve A, Cho Y, Ambade A, Szabo G.
J Neuroinflammation. 2018 Oct 27;15(1):298. doi: 10.1186/s12974-018-1328-9.

NLRP3/Caspase-1 inflammasome activation is decreased in alveolar macrophages in patients with lung cancer.
Lasithiotaki I, Tsitoura E, Samara KD, Trachalaki A, Charalambous I, Tzanakis N, Antoniou KM.
PLoS One. 2018 Oct 26;13(10):e0205242. doi: 10.1371/journal.pone.0205242. eCollection 2018.

Anti-Depressant-Like Effect of Sinomenine on Chronic Unpredictable Mild Stress-Induced Depression in a Mouse Model.
Liu S, Xu S, Wang Z, Guo Y, Pan W, Shen Z.
Med Sci Monit. 2018 Oct 26;24:7646-7653. doi: 10.12659/MSM.908422.

Inflammatory Potential of Four Different Phases of Calcium Pyrophosphate Relies on NF-κB Activation and MAPK Pathways.
Campillo-Gimenez L, Renaudin F, Jalabert M, Gras P, Gosset M, Rey C, Sarda S, Collet C, Cohen-Solal M, Combes C, Lioté F, Ea HK.
Front Immunol. 2018 Oct 9;9:2248. doi: 10.3389/fimmu.2018.02248. eCollection 2018.

Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Liu H, Sun Y, Zhang Y, Yang G, Guo L, Zhao Y, Pei Z.
Inflammation. 2019 Apr;42(2):516-525. doi: 10.1007/s10753-018-0909-1. 

A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis
Ramírez LA, Pérez-Padilla EA, García-Oscos F, Salgado H, Atzori M, Pineda JC.
Biomedica. 2018 Sep 1;38(3):437-450. doi: 10.7705/biomedica.v38i3.3688. Review.

Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice.
Staurengo-Ferrari L, Ruiz-Miyazawa KW, Pinho-Ribeiro FA, Fattori V, Zaninelli TH, Badaro-Garcia S, Borghi SM, Carvalho TT, Alves-Filho JC, Cunha TM, Cunha FQ,
Casagrande R, Verri WA Jr.
Front Pharmacol. 2018 Oct 2;9:1123. doi: 10.3389/fphar.2018.01123. eCollection 2018.

Oxidative stress does not contribute to the release of proinflammatory cytokines through activating the Nod-like receptor protein 3 inflammasome in patients with obstructive sleep apnoea.
Tang T, Huang Q, Liu J, Zhou X, Du J, Wu H, Li Z.
Sleep Breath. 2019 Jun;23(2):535-542. doi: 10.1007/s11325-018-1726-3. Epub 2018 Oct 3.

Identification of β-Sitosterol as in Vitro Anti-Inflammatory Constituent in Moringa oleifera.
Liao PC, Lai MH, Hsu KP, Kuo YH, Chen J, Tsai MC, Li CX, Yin XJ, Jeyashoke N, Chao LK.
J Agric Food Chem. 2018 Oct 17;66(41):10748-10759. doi: 10.1021/acs.jafc.8b04555. Epub 2018 Oct 3.

Inhibition of protein kinase R protects against palmitic acid-induced inflammation, oxidative stress, and apoptosis through the JNK/NF-kB/NLRP3 pathway in cultured H9C2 cardiomyocytes.
Mangali S, Bhat A, Udumula MP, Dhar I, Sriram D, Dhar A.
J Cell Biochem. 2019 Mar;120(3):3651-3663. doi: 10.1002/jcb.27643. Epub 2018 Sep 27.

Chelidonine suppresses LPS-Induced production of inflammatory mediators through the inhibitory of the TLR4/NF-κB signaling pathway in RAW264.7 macrophages.
Liao W, He X, Yi Z, Xiang W, Ding Y.
Biomed Pharmacother. 2018 Nov;107:1151-1159. doi: 10.1016/j.biopha.2018.08.094. Epub 2018 Aug 28.

15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in miceRuiz-Miyazawa KW, Staurengo-Ferrari L, Pinho-Ribeiro FA, Fattori V, Zaninelli TH, Badaro-Garcia S, Borghi SM, Andrade KC, Clemente-Napimoga JT, Alves-Filho JC, Cu
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Sci Rep. 2018 Sep 18;8(1):13979. doi: 10.1038/s41598-018-32334-0.

Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction.
Li X, Wang T, Zhang D, Li H, Shen H, Ding X, Chen G.
Neuropharmacology. 2018 Oct;141:305-315. doi: 10.1016/j.neuropharm.2018.09.015. Epub 2018 Sep 12.

Coptidis Rhizoma inhibits NLRP3 inflammasome activation and alleviates renal damage in early obesity-related glomerulopathy.
Ren Y, Wang D, Lu F, Zou X, Xu L, Wang K, Huang W, Su H, Zhang C, Gao Y, Dong H.
Phytomedicine. 2018 Oct 1;49:52-65. doi: 10.1016/j.phymed.2018.05.019. Epub 2018 Jun 7.

Toll-Like Receptor 4 and NLRP3 Caspase 1- Interleukin-1β-Axis are Not Involved in Colon Ascendens Stent Peritonitis-Associated Heart Disease.
Alarcón MML, Ruocco JF, Ferreira F, Paula-Neto HA, Sepúlveda M, Vila Petroff M, Carvalho AB, Ramos IP, Branda HJ, Paiva CN, Medei E.
Shock. 2018 Oct;50(4):483-492. doi: 10.1097/SHK.0000000000001059.

[Effects of GBE50 on LPS/ATP induced NLRP3 inflammasome activation in primary rat microglia].
Liu FQ, Gao Q, Wang DD, Zhang ZX.
Zhongguo Zhong Yao Za Zhi. 2018 Aug;43(16):3346-3352. doi: 10.19540/j.cnki.cjcmm.20180504.001. Chinese. 

Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling.
McWherter C, Choi YJ, Serrano RL, Mahata SK, Terkeltaub R, Liu-Bryan R.
Arthritis Res Ther. 2018 Sep 6;20(1):204. doi: 10.1186/s13075-018-1699-4.

Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3Inflammasome.
Wong WT, Li LH, Rao YK, Yang SP, Cheng SM, Lin WY, Cheng CC, Chen A, Hua KF.
Front Immunol. 2018 Aug 22;9:1920. doi: 10.3389/fimmu.2018.01920. eCollection 2018.

Complement regulatory protein CD46 induces autophagy against oxidative stress-mediated apoptosis in normal and asthmatic airway epithelium.
Tsai YG, Wen YS, Wang JY, Yang KD, Sun HL, Liou JH, Lin CY.
Sci Rep. 2018 Aug 28;8(1):12973. doi: 10.1038/s41598-018-31317-5.

Soluble Aβ1-42 suppresses TNF-α and activates NLRP3 inflammasome in THP-1 macrophages.
Gupta M, Wani A, Ul Ahsan A, Chopra M, Vishwakarma RA, Singh G, Kumar A.
Cytokine. 2018 Nov;111:84-87. doi: 10.1016/j.cyto.2018.07.026. Epub 2018 Aug 17.

Surfactant Protein D Dampens Lung Injury by Suppressing NLRP3 Inflammasome Activation and NF-κB Signaling in Acute Pancreatitis.
Yu J, Ni L, Zhang X, Zhang J, Abdel-Razek O, Wang G.
Shock. 2019 May;51(5):557-568. doi: 10.1097/SHK.0000000000001244.

Synthesis of a hemin-containing copolymer as a novel immunostimulator that induces IFN-gamma production.
Hoshi K, Yamazaki T, Yoshikawa C, Tsugawa W, Ikebukuro K, Sode K.
Int J Nanomedicine. 2018 Aug 2;13:4461-4472. doi: 10.2147/IJN.S166259. eCollection 2018.

Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways.
Zhu X, Shi J, Li H.
Biomed Pharmacother. 2018 Oct;106:976-982. doi: 10.1016/j.biopha.2018.07.045. Epub 2018 Jul 14.

The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice.
Wang J, Wang L, Zhou J, Qin A, Chen Z.
Biomed Pharmacother. 2018 Oct;106:1250-1257. doi: 10.1016/j.biopha.2018.07.063. Epub 2018 Jul 20.

AlCl3 inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production through suppressing NF-κB signaling pathway in murine peritoneal macrophages.
Xu F, Ji Q, Zhang J, Huang W, Cao Z, Li Y.
Chemosphere. 2018 Oct;209:972-980. doi: 10.1016/j.chemosphere.2018.06.171. Epub 2018 Jun 28.

Hyperglycemia induces inflammatory mediators in the human chorionic villous.
Corrêa-Silva S, Alencar AP, Moreli JB, Borbely AU, de S Lima L, Scavone C, Damasceno DC, Rudge MVC, Bevilacqua E, Calderon IMP.
Cytokine. 2018 Nov;111:41-48. doi: 10.1016/j.cyto.2018.07.020. Epub 2018 Aug 13.

Provocative decompression causes diffuse vascular injury in mice mediated by microparticles containing interleukin-1β.
Thom SR, Bhopale VM, Yu K, Yang M.
J Appl Physiol (1985). 2018 Aug 16. doi: 10.1152/japplphysiol.00620.2018. [Epub ahead of print]

Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3inflammasome in microglia.
Huang MY, Tu CE, Wang SC, Hung YL, Su CC, Fang SH, Chen CS, Liu PL, Cheng WC, Huang YW, Li CY.
BMC Complement Altern Med. 2018 Aug 15;18(1):221. doi: 10.1186/s12906-018-2287-5.

C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation.
Richter K, Sagawe S, Hecker A, Küllmar M, Askevold I, Damm J, Heldmann S, Pöhlmann M, Ruhrmann S, Sander M, Schlüter KD, Wilker S, König IR, Kummer W, Padberg
W, Hone AJ, McIntosh JM, Zakrzewicz AT, Koch C, Grau V.
Front Immunol. 2018 Jul 30;9:1604. doi: 10.3389/fimmu.2018.01604. eCollection 2018.

Expression of pattern recognition receptors in porcine uterine epithelial cells in vivo and in culture.
Hamonic G, Pasternak JA, Forsberg NM, Käser T, Wilson HL.
Vet Immunol Immunopathol. 2018 Aug;202:1-10. doi: 10.1016/j.vetimm.2018.06.006. Epub 2018 Jun 7.

NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis.
Marchetti C, Swartzwelter B, Koenders MI, Azam T, Tengesdal IW, Powers N, de Graaf DM, Dinarello CA, Joosten LAB.
Arthritis Res Ther. 2018 Aug 3;20(1):169. doi: 10.1186/s13075-018-1664-2.

Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3inflammasome activation via an AhR/Nrf2/NQO1 pathway.
Wang K, Lv Q, Miao YM, Qiao SM, Dai Y, Wei ZF.
Biochem Pharmacol. 2018 Sep;155:494-509. doi: 10.1016/j.bcp.2018.07.039. Epub 2018 Jul 31.

Replacing the 238th aspartic acid with an arginine impaired the oligomerization activity and inflammation-inducing property of pyolysin.
Zhang W, Wang H, Wang B, Zhang Y, Hu Y, Ma B, Wang J.
Virulence. 2018;9(1):1112-1125. doi: 10.1080/21505594.2018.1491256.

Sophocarpine attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-κB activation.
Li X, Wang M, Hong H, Luo C, Liu Z, Yang R.
Immunol Res. 2018 Aug;66(4):521-527. doi: 10.1007/s12026-018-9012-9.

Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients.
Pereira NS, Queiroga TBD, Nunes DF, Andrade CM, Nascimento MSL, Do-Valle-Matta MA, da Câmara ACJ, Galvão LMDC, Guedes PMM, Chiari E.
PLoS Negl Trop Dis. 2018 Jul 25;12(7):e0006589. doi: 10.1371/journal.pntd.0006589. eCollection 2018 Jul.

Daphnetin alleviates lipopolysaccharide/d-galactosamine-induced acute liver failure via the inhibition of NLRP3, MAPK and NF-κB, and the induction of autophagy.
Lv H, Fan X, Wang L, Feng H, Ci X.
Int J Biol Macromol. 2018 Nov;119:240-248. doi: 10.1016/j.ijbiomac.2018.07.101. Epub 2018 Jul 19.

Artesunate ameliorates high glucose-induced rat glomerular mesangial cell injury by suppressing the TLR4/NF-κB/NLRP3 inflammasome pathway.
Sun Z, Ma Y, Chen F, Wang S, Chen B, Shi J.
Chem Biol Interact. 2018 Sep 25;293:11-19. doi: 10.1016/j.cbi.2018.07.011. Epub 2018 Jul 19.

Ginsenoside Rd ameliorates colitis by inducing p62-driven mitophagy-mediated NLRP3inflammasome inactivation in mice.
Liu C, Wang J, Yang Y, Liu X, Zhu Y, Zou J, Peng S, Le TH, Chen Y, Zhao S, He B, Mi Q, Zhang X, Du Q.
Biochem Pharmacol. 2018 Sep;155:366-379. doi: 10.1016/j.bcp.2018.07.010. Epub 2018 Jul 25.

Ex vivo model of epilepsy in organotypic slices-a new tool for drug screening.
Magalhães DM, Pereira N, Rombo DM, Beltrão-Cavacas C, Sebastião AM, Valente CA.
J Neuroinflammation. 2018 Jul 11;15(1):203. doi: 10.1186/s12974-018-1225-2.

Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer’s disease.
Wang Y, Wang M, Xu M, Li T, Fan K, Yan T, Xiao F, Bi K, Jia Y.
Int Immunopharmacol. 2018 Sep;62:77-85. doi: 10.1016/j.intimp.2018.06.042. Epub 2018 Jul 5.

Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures.
Ślusarczyk J, Trojan E, Głombik K, Piotrowska A, Budziszewska B, Kubera M, Popiołek-Barczyk K, Lasoń W, Mika J, Basta-Kaim A.
Int J Mol Sci. 2018 Jul 5;19(7). pii: E1965. doi: 10.3390/ijms19071965.

HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy.
Thangaraj A, Periyasamy P, Liao K, Bendi VS, Callen S, Pendyala G, Buch S.
Autophagy. 2018;14(9):1596-1619. doi: 10.1080/15548627.2018.1476810. Epub 2018 Jul 26.

Lower High-Density Lipoproteins Levels During Human Immunodeficiency Virus Type 1 Infection Are Associated With Increased Inflammatory Markers and Disease Progression.
Marín-Palma D, Castro GA, Cardona-Arias JA, Urcuqui-Inchima S, Hernandez JC.
Front Immunol. 2018 Jun 14;9:1350. doi: 10.3389/fimmu.2018.01350. eCollection 2018.

Cyclic Stretching Exacerbates Tendinitis by Enhancing NLRP3 Inflammasome Activity via F-Actin Depolymerization.
Chen Q, Zhou J, Zhang B, Chen Z, Luo Q, Song G.
Inflammation. 2018 Oct;41(5):1731-1743. doi: 10.1007/s10753-018-0816-5.

Increased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes.
Cataño Cañizales YG, Uresti Rivera EE, García Jacobo RE, Portales Perez DP, Yadira B, Rodriguez Rivera JG, Amaro RG, Enciso Moreno JA, García Hernández MH.
Iran J Immunol. 2018 Jun;15(2):142-155. doi: IJIv15i2A7.

Electro-Acupuncture Alleviates Chronic Unpredictable Stress-Induced Depressive- and Anxiety-Like Behavior and Hippocampal Neuroinflammation in Rat Model of Depression.
Yue N, Li B, Yang L, Han QQ, Huang HJ, Wang YL, Wang J, Yu R, Wu GC, Liu Q, Yu J.
Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018.

Propofol Promotes Ankle Fracture Healing in Children by Inhibiting Inflammatory Response.
Zhou P, Liu H, Wu Y, Chen D.
Med Sci Monit. 2018 Jun 25;24:4379-4385. doi: 10.12659/MSM.908592.

Autophagy Impairment Is Associated With Increased Inflammasome Activation and Reversal Reaction Development in Multibacillary Leprosy.
de Mattos Barbosa MG, de Andrade Silva BJ, Assis TQ, da Silva Prata RB, Ferreira H, Andrade PR, da Paixão de Oliveira JA, Sperandio da Silva GM, da Costa Nery JA, Sarno EN, Pinheiro RO.
Front Immunol. 2018 Jun 4;9:1223. doi: 10.3389/fimmu.2018.01223. eCollection 2018.

Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis
Guo Q, Wu Y, Hou Y, Liu Y, Liu T, Zhang H, Fan C, Guan H, Li Y, Shan Z, Teng W.
Front Immunol. 2018 Jun 4;9:1197. doi: 10.3389/fimmu.2018.01197. eCollection 2018.

The Extract of D. dasycarpus Ameliorates Oxazolone-Induced Skin Damage in Mice by Anti-Inflammatory and Antioxidant Mechanisms.
Chang TM, Yang TY, Niu YL, Huang HC.
Antioxidants (Basel). 2018 Jun 15;7(6). pii: E77. doi: 10.3390/antiox7060077.

Anti-Inflammatory Action of Sitagliptin and Linagliptin in Doxorubicin Nephropathy.
Jo CH, Kim S, Park JS, Kim GH.
Kidney Blood Press Res. 2018;43(3):987-999. doi: 10.1159/000490688. Epub 2018 Jun 15.

Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome.
Wan Y, Xu L, Wang Y, Tuerdi N, Ye M, Qi R.
Eur J Pharmacol. 2018 Aug 15;833:545-554. doi: 10.1016/j.ejphar.2018.06.016. Epub 2018 Jun 18.

4′-Methoxyresveratrol Alleviated AGE-Induced Inflammation via RAGE-Mediated NF-κB and NLRP3Inflammasome Pathway.
Yu W, Tao M, Zhao Y, Hu X, Wang M.
Molecules. 2018 Jun 14;23(6). pii: E1447. doi: 10.3390/molecules23061447.

Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain.
Chen Y, Yin M, Cao X, Hu G, Xiao M.
Aging Dis. 2018 Jun 1;9(3):374-390. doi: 10.14336/AD.2017.0706. eCollection 2018 Jun.

l-Homocarnosine attenuates inflammation in cerebral ischemia-reperfusion injury through inhibition of nod-like receptor protein 3 inflammasome.
Huang J, Wang T, Yu D, Fang X, Fan H, Liu Q, Yi G, Yi X, Liu Q.
Int J Biol Macromol. 2018 Oct 15;118(Pt A):357-364. doi: 10.1016/j.ijbiomac.2018.06.032. Epub 2018 Jun 8.

Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation.
Lang T, Lee JPW, Elgass K, Pinar AA, Tate MD, Aitken EH, Fan H, Creed SJ, Deen NS, Traore DAK, Mueller I, Stanisic D, Baiwog FS, Skene C, Wilce MCJ, Mansell A, Morand EF, Harris J.
Nat Commun. 2018 Jun 8;9(1):2223. doi: 10.1038/s41467-018-04581-2.

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis.
Grebe A, Hoss F, Latz E.
Circ Res. 2018 Jun 8;122(12):1722-1740. doi: 10.1161/CIRCRESAHA.118.311362. Review.

Dexmedetomidine attenuates traumatic brain injury: action pathway and mechanisms.
Wang D, Xu X, Wu YG, Lyu L, Zhou ZW, Zhang JN.
Neural Regen Res. 2018 May;13(5):819-826. doi: 10.4103/1673-5374.232529.

INT-777, a bile acid receptor agonist, extenuates pancreatic acinar cells necrosis in a mouse model of acute pancreatitis.
Li B, Yang N, Li C, Li C, Gao K, Xie X, Dong X, Yang J, Yang Q, Tong Z, Lu G, Li W.
Biochem Biophys Res Commun. 2018 Sep 3;503(1):38-44. doi: 10.1016/j.bbrc.2018.05.120. Epub 2018 Jun 7.

Huanglian-Wendan Decoction Inhibits NF-κB/NLRP3 Inflammasome Activation in Liver and Brain of Rats Exposed to Chronic Unpredictable Mild Stress.
Jia KK, Ding H, Yu HW, Dong TJ, Pan Y, Kong LD.
Mediators Inflamm. 2018 Apr 29;2018:3093516. doi: 10.1155/2018/3093516. eCollection 2018.

Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation.
Ruiz-Miyazawa KW, Pinho-Ribeiro FA, Borghi SM, Staurengo-Ferrari L, Fattori V, Amaral FA, Teixeira MM, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA
J Agric Food Chem. 2018 Jun 27;66(25):6269-6280. doi: 10.1021/acs.jafc.8b00959. Epub 2018 Jun 13.

Hydrogen-Rich Saline Attenuates Acute Lung Injury Induced by Limb Ischemia/Reperfusion via Down-Regulating Chemerin and NLRP3 in Rats.
Zou R, Wang MH, Chen Y, Fan X, Yang B, Du J, Wang XB, Liu KX, Zhou J.
Shock. 2019 Jul;52(1):134-141. doi: 10.1097/SHK.0000000000001194.

Acute adrenal cortex injury during cardiopulmonary bypass in a canine model.
Mei B, Yang S, Yue Y, Hou J, Wang K, Chen G, Liang M, Wu Z.
J Thorac Cardiovasc Surg. 2018 Aug;156(2):696-706. doi: 10.1016/j.jtcvs.2018.03.151. Epub 2018 Apr 11.

Fecal bacteria from Crohn’s disease patients more potently activated NOD-like receptors and Toll-like receptors in macrophages, in an IL-4-repressible fashion.
Gu J, Liu G, Xing J, Song H, Wang Z.
Microb Pathog. 2018 Aug;121:40-44. doi: 10.1016/j.micpath.2018.05.009. Epub 2018 May 9.

Effects and molecular mechanisms of intrauterine infection/inflammation on lung development.
Pan J, Zhan C, Yuan T, Wang W, Shen Y, Sun Y, Wu T, Gu W, Chen L, Yu H.
Respir Res. 2018 May 10;19(1):93. doi: 10.1186/s12931-018-0787-y.

Mycobacterium tuberculosis PPE60 antigen drives Th1/Th17 responses via Toll-like receptor 2-dependent maturation of dendritic cells.
Su H, Zhang Z, Liu Z, Peng B, Kong C, Wang H, Zhang Z, Xu Y.
J Biol Chem. 2018 Jun 29;293(26):10287-10302. doi: 10.1074/jbc.RA118.001696. Epub 2018 May 8.

Pterostilbene inhibits amyloid-β-induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase-1 inflammasome pathway.
Li Q, Chen L, Liu X, Li X, Cao Y, Bai Y, Qi F.
J Cell Biochem. 2018 Aug;119(8):7053-7062. doi: 10.1002/jcb.27023. Epub 2018 May 8.

Inflammation and atherosclerosis: Cardiovascular evaluation in patients with autoimmune diseases.
Escárcega RO, Lipinski MJ, García-Carrasco M, Mendoza-Pinto C, Galvez-Romero JL, Cervera R.
Autoimmun Rev. 2018 Jul;17(7):703-708. doi: 10.1016/j.autrev.2018.01.021. Epub 2018 May 3. Review.

Immunological Behavior Analysis of Muscle Cells under IFN-γ Stimulation in Vitro and in Vivo.
Ding M, Huang T, Zhu R, Gu R, Shi D, Xiao J, Guo M, Li J, Hu J, Liao H.
Anat Rec (Hoboken). 2018 Sep;301(9):1551-1563. doi: 10.1002/ar.23834. Epub 2018 Jul 2.

Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway.
Tang P, Gu JM, Xie ZA, Gu Y, Jie ZW, Huang KM, Wang JY, Fan SW, Jiang XS, Hu ZJ.
Free Radic Biol Med. 2018 May 20;120:368-379. doi: 10.1016/j.freeradbiomed.2018.04.008. Epub 2018 Apr 9.

Effect of Soluble Epoxide Hydrolase in Hyperoxic Acute Lung Injury in Mice.
Li PS, Tao W, Yang LQ, Shu YS.
Inflammation. 2018 Jun;41(3):1065-1072. doi: 10.1007/s10753-018-0758-y.

Atractylodin attenuates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3inflammasome and TLR4 pathways.
Tang F, Fan K, Wang K, Bian C.
J Pharmacol Sci. 2018 Apr;136(4):203-211. doi: 10.1016/j.jphs.2017.11.010. Epub 2018 Feb 2.

Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.
Wang C, Hockerman S, Jacobsen EJ, Alippe Y, Selness SR, Hope HR, Hirsch JL, Mnich SJ, Saabye MJ, Hood WF, Bonar SL, Abu-Amer Y, Haimovich A, Hoffman HM, Monahan JB, Mbalaviele G.
J Exp Med. 2018 May 7;215(5):1315-1325. doi: 10.1084/jem.20172063. Epub 2018 Mar 16.

RIP3-deficience attenuates potassium oxonate-induced hyperuricemia and kidney injury.
Wang K, Hu L, Chen JK.
Biomed Pharmacother. 2018 May;101:617-626. doi: 10.1016/j.biopha.2018.02.010. Epub 2018 Mar 22.

Mammalian Target of Rapamycin Inhibition in Trypanosoma cruzi-Infected Macrophages Leads to an Intracellular Profile That Is Detrimental for Infection.
Rojas Márquez JD, Ana Y, Baigorrí RE, Stempin CC, Cerban FM.
Front Immunol. 2018 Feb 20;9:313. doi: 10.3389/fimmu.2018.00313. eCollection 2018.

Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes.
Birnbaum Y, Bajaj M, Yang HC, Ye Y.
Cardiovasc Drugs Ther. 2018 Apr;32(2):135-145. doi: 10.1007/s10557-018-6778-x.

Inhibitory effects of superoxide dismutase 3 on Propionibacterium acnes-induced skin inflammation.
Nguyen CT, Sah SK, Zouboulis CC, Kim TY.
Sci Rep. 2018 Mar 5;8(1):4024. doi: 10.1038/s41598-018-22132-z. Erratum in: Sci Rep. 2018 Aug 29;8(1):13150

Oleanolic acid acetate attenuates polyhexamethylene guanidine phosphate-induced pulmonary inflammation and fibrosis in mice.
Kim MS, Han JY, Kim SH, Jeon D, Kim HY, Lee SW, Rho MC, Lee K.
Respir Physiol Neurobiol. 2018 Jun;252-253:1-9. doi: 10.1016/j.resp.2018.03.001. Epub 2018 Mar 2.

Preterm Life in Sterile Conditions: A Study on Preterm, Germ-Free Piglets.
Splichalova A, Slavikova V, Splichalova Z, Splichal I.
Front Immunol. 2018 Feb 14;9:220. doi: 10.3389/fimmu.2018.00220. eCollection 2018.

Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice.
Lebeaupin C, Vallée D, Rousseau D, Patouraux S, Bonnafous S, Adam G, Luciano F, Luci C, Anty R, Iannelli A, Marchetti S, Kroemer G, Lacas-Gervais S, Tran A, Gual P,
Bailly-Maitre B.
Hepatology. 2018 Aug;68(2):515-532. doi: 10.1002/hep.29847. Epub 2018 May 18.

Alendronate augments lipid A-induced IL-1β release and Smad3/NLRP3/ASC-dependent cell death.
Tamai R, Kiyoura Y.
Life Sci. 2018 Apr 1;198:8-17. doi: 10.1016/j.lfs.2018.02.014. Epub 2018 Feb 10.

The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy.
Chaurasia SS, Lim RR, Parikh BH, Wey YS, Tun BB, Wong TY, Luu CD, Agrawal R, Ghosh A, Mortellaro A, Rackoczy E, Mohan RR, Barathi VA.
Sci Rep. 2018 Feb 12;8(1):2847. doi: 10.1038/s41598-018-21198-z.

Luteolin alleviates NLRP3 inflammasome activation and directs macrophage polarization in lipopolysaccharide-stimulated RAW264.7 cells.
Zhang BC, Li Z, Xu W, Xiang CH, Ma YF.
Am J Transl Res. 2018 Jan 15;10(1):265-273. eCollection 2018.

Role of inflammatory response in liver diseases: Therapeutic strategies.
Del Campo JA, Gallego P, Grande L.
World J Hepatol. 2018 Jan 27;10(1):1-7. doi: 10.4254/wjh.v10.i1.1. Review.

Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation.
Gehrke N, Hövelmeyer N, Waisman A, Straub BK, Weinmann-Menke J, Wörns MA, Galle PR, Schattenberg JM.
J Hepatol. 2018 May;68(5):986-995. doi: 10.1016/j.jhep.2018.01.008. Epub 2018 Jan 31.

Obesity or Overweight, a Chronic Inflammatory Status in Male Reproductive System, Leads to Mice and Human Subfertility.
Fan W, Xu Y, Liu Y, Zhang Z, Lu L, Ding Z.
Front Physiol. 2018 Jan 4;8:1117. doi: 10.3389/fphys.2017.01117. eCollection 2017.

Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats.
Wang YL, Han QQ, Gong WQ, Pan DH, Wang LZ, Hu W, Yang M, Li B, Yu J, Liu Q.
J Neuroinflammation. 2018 Jan 17;15(1):21. doi: 10.1186/s12974-018-1054-3.

IL-6 receptor blockade ameliorates diabetic nephropathy via inhibiting inflammasome in mice.
Wu R, Liu X, Yin J, Wu H, Cai X, Wang N, Qian Y, Wang F.
Metabolism. 2018 Jun;83:18-24. doi: 10.1016/j.metabol.2018.01.002. Epub 2018 Jan 12.

Rosmarinic Acid Mitigates Lipopolysaccharide-Induced Neuroinflammatory Responses through the Inhibition of TLR4 and CD14 Expression and NF-κB and NLRP3 Inflammasome Activation.
Wei Y, Chen J, Hu Y, Lu W, Zhang X, Wang R, Chu K.
Inflammation. 2018 Mar;41(2):732-740. doi: 10.1007/s10753-017-0728-9.

Yupingfeng San Inhibits NLRP3 Inflammasome to Attenuate the Inflammatory Response in Asthma Mice.
Liu X, Shen J, Fan D, Qiu X, Guo Q, Zheng K, Luo H, Shu J, Lu C, Zhang G, Lu A, Ma C, He X.
Front Pharmacol. 2017 Dec 22;8:944. doi: 10.3389/fphar.2017.00944. eCollection 2017.

Molecular genetic investigation, clinical features, and response to treatment in 21 patients with Schnitzler syndrome.
Rowczenio DM, Pathak S, Arostegui JI, Mensa-Vilaro A, Omoyinmi E, Brogan P, Lipsker D, Scambler T, Owen R, Trojer H, Baginska A, Gillmore JD, Wechalekar AD, Lane T, Williams R, Youngstein T, Hawkins PN, Savic S, Lachmann HJ.
Blood. 2018 Mar 1;131(9):974-981. doi: 10.1182/blood-2017-10-810366. Epub 2017 Dec 28.

Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation.
Castelblanco M, Lugrin J, Ehirchiou D, Nasi S, Ishii I, So A, Martinon F, Busso N.
J Biol Chem. 2018 Feb 16;293(7):2546-2557. doi: 10.1074/jbc.M117.806869. Epub 2017 Dec 26.

Quaking Deficiency Amplifies Inflammation in Experimental Endotoxemia via the Aryl Hydrocarbon Receptor/Signal Transducer and Activator of Transcription 1-NF-κB Pathway.
Wang L, Zhai DS, Ruan BJ, Xu CM, Ye ZC, Lu HY, Jiang YH, Wang ZY, Xiang A, Yang Y, Yuan JL, Lu ZF.
Front Immunol. 2017 Dec 8;8:1754. doi: 10.3389/fimmu.2017.01754. eCollection 2017.

Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis by possible reduction of NLRP3 activation and up-regulation of NET expression.
Li Y, Pan Y, Gao L, Lu G, Zhang J, Xie X, Tong Z, Li B, Li G, Li W.
Biochem Biophys Res Commun. 2018 Jan 22;495(4):2439-2447. doi: 10.1016/j.bbrc.2017.12.090. Epub 2017 Dec 19.

Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica.
Zhang FK, Hou JL, Guo AJ, Tian AL, Sheng ZA, Zheng WB, Huang WY, Elsheikha HM, Zhu XQ.
Mol Immunol. 2018 Feb;94:18-26. doi: 10.1016/j.molimm.2017.12.007. Epub 2017 Dec 11.

Reduced inflammatory factor expression facilitates recovery after sciatic nerve injury in TLR4 mutant mice.
Tang G, Yao J, Shen R, Ji A, Ma K, Cong B, Wang F, Zhu L, Wang X, Ding Y, Zhang B.
Int Immunopharmacol. 2018 Feb;55:77-85. doi: 10.1016/j.intimp.2017.12.007. Epub 2017 Dec 22.

Selective NLRP3 (Pyrin Domain-Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage.
Ren H, Kong Y, Liu Z, Zang D, Yang X, Wood K, Li M, Liu Q.
Stroke. 2018 Jan;49(1):184-192. doi: 10.1161/STROKEAHA.117.018904. Epub 2017 Dec 6.

TLR4 and NLRP3 Caspase 1- IL-1β- Axis are not Involved in Colon Ascendens Stent Peritonitis (Casp)-Associated Heart Disease.
Alarcón MML, Ruocco JF, Ferreira F, Paula-Neto HA, Sepúlveda M, Petroff MV, Carvalho AB, Ramos IP, Branda HJ, Paiva CN, Medei E.
Shock. 2017 Nov 15. doi: 10.1097/SHK.0000000000001059. [Epub ahead of print]

Glucose-6-Phosphatase Catalytic Subunit 3 (G6PC3) Deficiency Associated With Autoinflammatory Complications.
Mistry A, Scambler T, Parry D, Wood M, Barcenas-Morales G, Carter C, Doffinger R, Savic S.
Front Immunol. 2017 Nov 6;8:1485. doi: 10.3389/fimmu.2017.01485. eCollection 2017.

The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP release.
Mugisho OO, Green CR, Kho DT, Zhang J, Graham ES, Acosta ML, Rupenthal ID.
Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):385-393. doi: 10.1016/j.bbagen.2017.11.015. Epub 2017 Nov 21.

Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect.
Yang Y, Zhang X, Xu M, Wu X, Zhao F, Zhao C.
Int Immunopharmacol. 2018 Jan;54:153-162. doi: 10.1016/j.intimp.2017.11.013. Epub 2017 Nov 14.

Marantodes pumilum (Blume) Kuntze Inhibited Secretion of Lipopolysaccharide- and Monosodium Urate Crystal-stimulated Cytokines and Plasma Prostaglandin E2.
Rahmi EP, Jamal JA, Kumolosasi E, Jalil J, Aladdin NA.
Pharmacogn Mag. 2017 Oct;13(Suppl 3):S578-S586. doi: 10.4103/pm.pm_35_17. Epub 2017 Oct 11.

Suppression of inflammatory and infection responses in lung macrophages by eucalyptus oil and its constituent 1,8-cineole: Role of pattern recognition receptors TREM-1 and NLRP3, the MAP kinase regulator MKP-1, and NFκB.
Yadav N, Chandra H.
PLoS One. 2017 Nov 15;12(11):e0188232. doi: 10.1371/journal.pone.0188232. eCollection 2017.

Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
Shi A, Shi H, Wang Y, Liu X, Cheng Y, Li H, Zhao H, Wang S, Dong L.
Int Immunopharmacol. 2018 Jan;54:125-130. doi: 10.1016/j.intimp.2017.11.007. Epub 2017 Nov 9.

Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells.
Gómez DM, Urcuqui-Inchima S, Hernandez JC.
Innate Immun. 2017 Nov;23(8):697-708. doi: 10.1177/1753425917738331.

3-(Naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride attenuates NLRP3 inflammasome-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglial cells.
Yang JW, Yang SJ, Na JM, Hahn HG, Cho SW.
Biochem Biophys Res Commun. 2018 Jan 1;495(1):151-156. doi: 10.1016/j.bbrc.2017.10.131. Epub 2017 Oct 27.

Anti-inflammatory capacity of Lactobacillus rhamnosus GG in monophasic variant Salmonella infected piglets is correlated with impeding NLRP6-mediated host inflammatory responses.
Yu J, Zhu YH, Yang GY, Zhang W, Zhou D, Su JH, Wang JF.
Vet Microbiol. 2017 Oct;210:91-100. doi: 10.1016/j.vetmic.2017.08.008. Epub 2017 Aug 20.

[NLRP3 inflammasome induces pyroptosis in lung tissues of radiation-induced lung injury in mice].
Han R, Wu D, Deng S, Liu T, Zhang T, Xu Y.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Sep;33(9):1206-1211. Chinese. 

Diet-induced obesity leads to pro-inflammatory alterations to the vitreous humour of the eye in a rat model.
Collins KH, Herzog W, Reimer RA, Reno CR, Heard BJ, Hart DA.
Inflamm Res. 2018 Feb;67(2):139-146. doi: 10.1007/s00011-017-1102-y. Epub 2017 Oct 26.

The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3Inflammasome Activation in Murine Macrophages.
Pietrofesa RA, Woodruff P, Hwang WT, Patel P, Chatterjee S, Albelda SM, Christofidou-Solomidou M.
Oxid Med Cell Longev. 2017;2017:7395238. doi: 10.1155/2017/7395238. Epub 2017 Sep 13.

The extent of pyroptosis varies in different stages of apical periodontitis.
Cheng R, Feng Y, Zhang R, Liu W, Lei L, Hu T.
Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):226-237. doi: 10.1016/j.bbadis.2017.10.025. Epub 2017 Oct 21.

Advanced glycation end products impair NLRP3 inflammasome-mediated innate immune responses in macrophages.
Son S, Hwang I, Han SH, Shin JS, Shin OS, Yu JW.
J Biol Chem. 2017 Dec 15;292(50):20437-20448. doi: 10.1074/jbc.M117.806307. Epub 2017 Oct 19.

Baicalin protects AML-12 cells from lipotoxicity via the suppression of ER stress and TXNIP/NLRP3inflammasome activation.
Zhang J, Zhang H, Deng X, Zhang Y, Xu K.
Chem Biol Interact. 2017 Dec 25;278:189-196. doi: 10.1016/j.cbi.2017.10.010. Epub 2017 Oct 12.

Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome.
Han BC, Ahn H, Lee J, Jeon E, Seo S, Jang KH, Lee SH, Kim CH, Lee GS.
J Ginseng Res. 2017 Oct;41(4):513-523. doi: 10.1016/j.jgr.2016.10.001. Epub 2016 Oct 8.

Protective Effects of Microrna-22 Against Endothelial Cell Injury by Targeting NLRP3 Through Suppression of the Inflammasome Signaling Pathway in a Rat Model of Coronary Heart Disease.
Huang WQ, Wei P, Lin RQ, Huang F.
Cell Physiol Biochem. 2017;43(4):1346-1358. doi: 10.1159/000481846. Epub 2017 Oct 9.

Wogonoside alleviates inflammation induced by traumatic spinal cord injury by suppressing NF-κB and NLRP3 inflammasome activation.
Zhu Y, Zhu H, Wang Z, Gao F, Wang J, Zhang W.
Exp Ther Med. 2017 Oct;14(4):3304-3308. doi: 10.3892/etm.2017.4904. Epub 2017 Aug 8.

Expression and function of NOD-like receptors by human term gestation-associated tissues.
Bryant AH, Bevan RJ, Spencer-Harty S, Scott LM, Jones RH, Thornton CA.
Placenta. 2017 Oct;58:25-32. doi: 10.1016/j.placenta.2017.07.017. Epub 2017 Aug 2.

Cordycepin inhibits LPS-induced inflammatory responses by modulating NOD-Like Receptor Protein 3 inflammasome activation.
Yang J, Li YZ, Hylemon PB, Zhang LY, Zhou HP.
Biomed Pharmacother. 2017 Nov;95:1777-1788. doi: 10.1016/j.biopha.2017.09.103. Epub 2017 Oct 6.

Oroxylin A inhibits colitis by inactivating NLRP3 inflammasome.
Zhou W, Liu X, Zhang X, Tang J, Li Z, Wang Q, Hu R.
Oncotarget. 2017 Jul 22;8(35):58903-58917. doi: 10.18632/oncotarget.19440. eCollection 2017 Aug 29.

Plasma exosomal miR-223 expression regulates inflammatory responses during cardiac surgery with cardiopulmonary bypass.
Poon KS, Palanisamy K, Chang SS, Sun KT, Chen KB, Li PC, Lin TC, Li CY.
Sci Rep. 2017 Sep 7;7(1):10807. doi: 10.1038/s41598-017-09709-w.

Downregulated expression of miR-223 promotes Toll-like receptor-activated inflammatory responses in macrophages by targeting RhoB.
Zhang N, Fu L, Bu Y, Yao Y, Wang Y.
Mol Immunol. 2017 Nov;91:42-48. doi: 10.1016/j.molimm.2017.08.026. Epub 2017 Sep 4.

Teuvincenone F Suppresses LPS-Induced Inflammation and NLRP3 Inflammasome Activation by Attenuating NEMO Ubiquitination.
Zhao X, Pu D, Zhao Z, Zhu H, Li H, Shen Y, Zhang X, Zhang R, Shen J, Xiao W, Chen W.
Front Pharmacol. 2017 Aug 23;8:565. doi: 10.3389/fphar.2017.00565. eCollection 2017.

Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model: a translational study.
Spengler D, Winoto-Morbach S, Kupsch S, Vock C, Blöchle K, Frank S, Rintz N, Diekötter M, Janga H, Weckmann M, Fuchs S, Schromm AB, Fehrenbach H, Schütze S,
Krause MF.
Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L32-L53. doi: 10.1152/ajplung.00128.2017. Epub 2017 Aug 31.

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial.
Ridker PM, MacFadyen JG, Thuren T, Everett BM, Libby P, Glynn RJ; CANTOS Trial Group.
Lancet. 2017 Oct 21;390(10105):1833-1842. doi: 10.1016/S0140-6736(17)32247-X. Epub 2017 Aug 27.

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.
Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI,
Kanneganti TD, O’Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S.
Nat Microbiol. 2017 Oct;2(10):1435-1445. doi: 10.1038/s41564-017-0015-4. Epub 2017 Aug 28 

Esculentoside A exerts anti-inflammatory activity in microglial cells.
Yang H, Chen Y, Yu L, Xu Y.
Int Immunopharmacol. 2017 Oct;51:148-157. doi: 10.1016/j.intimp.2017.08.014. Epub 2017 Aug 30.

Blbulyan A, Martirosyan A, Petrek M, Navratilova Z, Manukyan G.
Georgian Med News. 2017 Jul-Aug;(268-269):12-17.

Stingray venom activates IL-33 producing cardiomyocytes, but not mast cell, to promote acute neutrophil-mediated injury.
Dos Santos JC, Grund LZ, Seibert CS, Marques EE, Soares AB, Quesniaux VF, Ryffel B, Lopes-Ferreira M, Lima C.
Sci Rep. 2017 Aug 11;7(1):7912. doi: 10.1038/s41598-017-08395-y.

Differential Regulation of IL-1β and IL-6 Release in Murine Macrophages.
Hirano S, Zhou Q, Furuyama A, Kanno S.
Inflammation. 2017 Dec;40(6):1933-1943. doi: 10.1007/s10753-017-0634-1.

Implication of REDD1 in the activation of inflammatory pathways.
Pastor F, Dumas K, Barthélémy MA, Regazzetti C, Druelle N, Peraldi P, Cormont M, Tanti JF, Giorgetti-Peraldi S.
Sci Rep. 2017 Aug 1;7(1):7023. doi: 10.1038/s41598-017-07182-z.

Amelioration of amyloid β-induced retinal inflammatory responses by a LXR agonist TO901317 is associated with inhibition of the NF-κB signaling and NLRP3 inflammasome.
Lei C, Lin R, Wang J, Tao L, Fu X, Qiu Y, Lei B.
Neuroscience. 2017 Sep 30;360:48-60. doi: 10.1016/j.neuroscience.2017.07.053. Epub 2017 Jul 29.

A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3inflammasome by neutralizing LPS and ATP.
Li LH, Ju TC, Hsieh CY, Dong WC, Chen WT, Hua KF, Chen WJ.
PLoS One. 2017 Jul 27;12(7):e0182057. doi: 10.1371/journal.pone.0182057. eCollection 2017.

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.
Cosin-Roger J, Simmen S, Melhem H, Atrott K, Frey-Wagner I, Hausmann M, de Vallière C, Spalinger MR, Spielmann P, Wenger RH, Zeitz J, Vavricka SR, Rogler G, Ruiz
Nat Commun. 2017 Jul 24;8(1):98. doi: 10.1038/s41467-017-00213-3.

LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma.
Cai TT, Ye SB, Liu YN, He J, Chen QY, Mai HQ, Zhang CX, Cui J, Zhang XS, Busson P, Zeng YX, Li J.
PLoS Pathog. 2017 Jul 21;13(7):e1006503. doi: 10.1371/journal.ppat.1006503. eCollection 2017 Jul.

Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.
Chimin P, Andrade ML, Belchior T, Paschoal VA, Magdalon J, Yamashita AS, Castro É, Castoldi A, Chaves-Filho AB, Yoshinaga MY, Miyamoto S, Câmara NO, Festuccia
J Lipid Res. 2017 Sep;58(9):1797-1807. doi: 10.1194/jlr.M074518. Epub 2017 Jul 5.

A preliminary study on the proinflammatory mechanisms of Treponema pallidum outer membrane protein Tp92 in human macrophages and HMEC-1 cells.
Luo X, Zhang X, Zhao T, Zeng T, Liu W, Deng M, Zhao F.
Microb Pathog. 2017 Sep;110:176-183. doi: 10.1016/j.micpath.2017.06.046. Epub 2017 Jun 29.

Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis.
Nasi S, Ea HK, So A, Busso N.
Front Pharmacol. 2017 Jun 13;8:282. doi: 10.3389/fphar.2017.00282. eCollection 2017.

Deficiency of NALP3 Signaling Impairs Liver Regeneration After Partial Hepatectomy.
Ando T, Ito H, Kanbe A, Hara A, Seishima M.
Inflammation. 2017 Oct;40(5):1717-1725. doi: 10.1007/s10753-017-0613-6.

Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro.
Ge H, Tang H, Liang Y, Wu J, Yang Q, Zeng L, Ma Z.
Drug Des Devel Ther. 2017 Jun 6;11:1663-1671. doi: 10.2147/DDDT.S133069. eCollection 2017.

The inhibition of NLRP3 signaling attenuates liver injury in an α-galactosylceramide-induced hepatitis model.
Kanbe A, Ito H, Omori Y, Hara A, Seishima M.
Biochem Biophys Res Commun. 2017 Aug 19;490(2):364-370. doi: 10.1016/j.bbrc.2017.06.049. Epub 2017 Jun 14.

Deletion of the Inflammasome Sensor Aim2 Mitigates Aβ Deposition and Microglial Activation but Increases Inflammatory Cytokine Expression in an Alzheimer Disease Mouse Model.
Wu PJ, Hung YF, Liu HY, Hsueh YP.
Neuroimmunomodulation. 2017;24(1):29-39. doi: 10.1159/000477092. Epub 2017 Jun 16.

Expression of TLR2, NOD1, and NOD2 and the NLRP3 Inflammasome in Renal Tubular Epithelial Cells of Male versus Female Mice.
DeWolf SE, Shigeoka AA, Scheinok A, Kasimsetty SG, Welch AK, McKay DB.
Nephron. 2017;137(1):68-76. doi: 10.1159/000456016. Epub 2017 Jun 15.

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage.
Cunha C, Santos C, Gomes C, Fernandes A, Correia AM, Sebastião AM, Vaz AR, Brites D.
Mol Neurobiol. 2018 May;55(5):4207-4224. doi: 10.1007/s12035-017-0631-2. Epub 2017 Jun 13.

Adipocyte-Macrophage Cross-Talk in Obesity.
Engin AB.
Adv Exp Med Biol. 2017;960:327-343. doi: 10.1007/978-3-319-48382-5_14. Review.

The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation.
Engin A.
Adv Exp Med Biol. 2017;960:221-245. doi: 10.1007/978-3-319-48382-5_9. Review.

The protective effect of Epimedii Folium and Curculiginis Rhizoma on Alzheimer’s disease by the inhibitions of NF-κB/MAPK pathway and NLRP3 inflammasome.
Lan Z, Xie G, Wei M, Wang P, Chen L.
Oncotarget. 2017 Jul 4;8(27):43709-43720. doi: 10.18632/oncotarget.12574.

Anti-hyperuricemic and anti-inflammatory actions of vaticaffinol isolated from Dipterocarpus alatus in hyperuricemic mice.
Chen YS, Chen CJ, Yan W, Ge HM, Kong LD.
Chin J Nat Med. 2017 May;15(5):330-340. doi: 10.1016/S1875-5364(17)30053-5.

Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs).
Kinnunen K, Piippo N, Loukovaara S, Hytti M, Kaarniranta K, Kauppinen A.
J Cell Commun Signal. 2017 Sep;11(3):275-279. doi: 10.1007/s12079-017-0396-4. Epub 2017 May 25.

Magnesium isoglycyrrhizinate blocks fructose-induced hepatic NF-κB/NLRP3 inflammasome activation and lipid metabolism disorder.
Zhao XJ, Yang YZ, Zheng YJ, Wang SC, Gu HM, Pan Y, Wang SJ, Xu HJ, Kong LD.
Eur J Pharmacol. 2017 Aug 15;809:141-150. doi: 10.1016/j.ejphar.2017.05.032. Epub 2017 May 17.

Activation of NLRP3 Inflammasome in Inflammatory Bowel Disease: Differences Between Crohn’s Disease and Ulcerative Colitis.
Lazaridis LD, Pistiki A, Giamarellos-Bourboulis EJ, Georgitsi M, Damoraki G, Polymeros D, Dimitriadis GD, Triantafyllou K.
Dig Dis Sci. 2017 Sep;62(9):2348-2356. doi: 10.1007/s10620-017-4609-8. Epub 2017 May 18.

Advanced glycation end products regulate interleukin-1β production in human placenta.
Seno K, Sase S, Ozeki A, Takahashi H, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T, Shirasuna K.
J Reprod Dev. 2017 Aug 19;63(4):401-408. doi: 10.1262/jrd.2017-032. Epub 2017 May 18.

[Recombinant Legionella pneumophila flagella protein A (rflaA) induces the secretion of IL-6 and IL-1β in RAW264.7 cells in vitro].
Jia L, Cao X, Yang Z.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 May;33(5):601-605. Chinese. 

Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy- and p62-dependent manners.
Ko JH, Yoon SO, Lee HJ, Oh JY.
Oncotarget. 2017 Jun 20;8(25):40817-40831. doi: 10.18632/oncotarget.17256.

Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder.
Alcocer-Gómez E, Casas-Barquero N, Williams MR, Romero-Guillena SL, Cañadas-Lozano D, Bullón P, Sánchez-Alcazar JA, Navarro-Pando JM, Cordero MD.
Pharmacol Res. 2017 Jul;121:114-121. doi: 10.1016/j.phrs.2017.04.028. Epub 2017 May 2.

Baicalin ameliorates chronic unpredictable mild stress-induced depressive behavior: Involving the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex.
Liu X, Liu C.
Int Immunopharmacol. 2017 Jul;48:30-34. doi: 10.1016/j.intimp.2017.04.019. Epub 2017 May 3.

SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor.
Ye Y, Bajaj M, Yang HC, Perez-Polo JR, Birnbaum Y.
Cardiovasc Drugs Ther. 2017 Apr;31(2):119-132. doi: 10.1007/s10557-017-6725-2.

Prostaglandin E2 produced following infection with Theiler’s virus promotes the pathogenesis of demyelinating disease.
Kim SJ, Jin YH, Kim BS.
PLoS One. 2017 Apr 26;12(4):e0176406. doi: 10.1371/journal.pone.0176406. eCollection 2017.

Analysis of PM2.5-induced cytotoxicity in human HaCaT cells based on a microfluidic system.
Zhang Y, Zheng L, Tuo J, Liu Q, Zhang X, Xu Z, Liu S, Sui G.
Toxicol In Vitro. 2017 Sep;43:1-8. doi: 10.1016/j.tiv.2017.04.018. Epub 2017 Apr 18.

Nanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides.
Jin L, Ding M, Oklopcic A, Aghdasi B, Xiao L, Li Z, Jevtovic-Todorovic V, Li X.
Nanomedicine. 2017 Aug;13(6):2049-2059. doi: 10.1016/j.nano.2017.03.015. Epub 2017 Apr 9.

Interleukin-18 protects mice from Enterovirus 71 infection.
Li Z, Wang H, Chen Y, Niu J, Guo Q, Leng Q, Huang Z, Deng Z, Meng G.
Cytokine. 2017 Aug;96:132-137. doi: 10.1016/j.cyto.2017.04.002. Epub 2017 Apr 9.

Diosmetin Alleviates Lipopolysaccharide-Induced Acute Lung Injury through Activating the Nrf2 Pathway and Inhibiting the NLRP3 Inflammasome.
Liu Q, Ci X, Wen Z, Peng L.
Biomol Ther (Seoul). 2018 Mar 1;26(2):157-166. doi: 10.4062/biomolther.2016.234.

Protective Effect of Amygdalin on LPS-Induced Acute Lung Injury by Inhibiting NF-κB and NLRP3Signaling Pathways.
Zhang A, Pan W, Lv J, Wu H.
Inflammation. 2017 Jun;40(3):745-751. doi: 10.1007/s10753-017-0518-4.

Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model.
Carlos D, Costa FR, Pereira CA, Rocha FA, Yaochite JN, Oliveira GG, Carneiro FS, Tostes RC, Ramos SG, Zamboni DS, Camara NO, Ryffel B, Silva JS.
Front Immunol. 2017 Feb 27;8:164. doi: 10.3389/fimmu.2017.00164. eCollection 2017.

Blockade of P2X4 Receptors Inhibits Neuropathic Pain-Related Behavior by Preventing MMP-9 Activation and, Consequently, Pronociceptive Interleukin Release in a Rat Model.
Jurga AM, Piotrowska A, Makuch W, Przewlocka B, Mika J.
Front Pharmacol. 2017 Feb 16;8:48. doi: 10.3389/fphar.2017.00048. eCollection 2017.

NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy.
Loukovaara S, Piippo N, Kinnunen K, Hytti M, Kaarniranta K, Kauppinen A.
Acta Ophthalmol. 2017 Dec;95(8):803-808. doi: 10.1111/aos.13427. Epub 2017 Mar 8.

Cholesterol crystals enhance TLR2- and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis.
Køllgaard T, Enevold C, Bendtzen K, Hansen PR, Givskov M, Holmstrup P, Nielsen CH.
PLoS One. 2017 Feb 24;12(2):e0172773. doi: 10.1371/journal.pone.0172773. eCollection 2017.

Sinigrin inhibits production of inflammatory mediators by suppressing NF-κB/MAPK pathways or NLRP3 inflammasome activation in macrophages.
Lee HW, Lee CG, Rhee DK, Um SH, Pyo S.
Int Immunopharmacol. 2017 Apr;45:163-173. doi: 10.1016/j.intimp.2017.01.032. Epub 2017 Feb 20.

SIRT1 Regulates the Inflammatory Response of Vascular Adventitial Fibroblasts through Autophagy and Related Signaling Pathway.
Wang WR, Li TT, Jing T, Li YX, Yang XF, He YH, Zhang W, Lin R, Zhang JY.
Cell Physiol Biochem. 2017;41(2):569-582. doi: 10.1159/000457878. Epub 2017 Feb 3.

Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress.
Liu YM, Shen JD, Xu LP, Li HB, Li YC, Yi LT.
Int Immunopharmacol. 2017 Apr;45:128-134. doi: 10.1016/j.intimp.2017.02.007. Epub 2017 Feb 14.

Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome.
Xiao Q, Qu Z, Zhao Y, Yang L, Gao P.
Evid Based Complement Alternat Med. 2017;2017:2495496. doi: 10.1155/2017/2495496. Epub 2017 Jan 19.

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.
Mridha AR, Wree A, Robertson AAB, Yeh MM, Johnson CD, Van Rooyen DM, Haczeyni F, Teoh NC, Savard C, Ioannou GN, Masters SL, Schroder K, Cooper MA, Feldstein AE, Farrell GC.
J Hepatol. 2017 May;66(5):1037-1046. doi: 10.1016/j.jhep.2017.01.022. Epub 2017 Feb 3.

Activated microglia trigger inflammasome activation and lysosomal destabilization in human RPE cells.
Nebel C, Aslanidis A, Rashid K, Langmann T.
Biochem Biophys Res Commun. 2017 Mar 11;484(3):681-686. doi: 10.1016/j.bbrc.2017.01.176. Epub 2017 Feb 1.

Therapeutic efficacy of carboxyamidotriazole on 2,4,6-trinitrobenzene sulfonic acid-induced colitis model is associated with the inhibition of NLRP3 inflammasome and NF-κB activation.
Du X, Chen W, Wang Y, Chen C, Guo L, Ju R, Li J, Zhang D, Zhu L, Ye C.
Int Immunopharmacol. 2017 Apr;45:16-25. doi: 10.1016/j.intimp.2017.01.015. Epub 2017 Jan 31.

Genetically determined high activity of IL-12 and IL-18 in ulcerative colitis and TLR5 in Crohns disease were associated with non-response to anti-TNF therapy.
Bank S, Andersen PS, Burisch J, Pedersen N, Roug S, Galsgaard J, Turino SY, Brodersen JB, Rashid S, Rasmussen BK, Avlund S, Olesen TB, Hoffmann HJ, Nexø BA, Sode J,
Vogel U, Andersen V.
Pharmacogenomics J. 2018 Jan;18(1):87-97. doi: 10.1038/tpj.2016.84. Epub 2017 Jan 31.

Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9.
Rhoads JP, Lukens JR, Wilhelm AJ, Moore JL, Mendez-Fernandez Y, Kanneganti TD, Major AS.
J Immunol. 2017 Mar 1;198(5):2105-2114. doi: 10.4049/jimmunol.1601563. Epub 2017 Jan 27.

The cardioprotective effect of total flavonoids on myocardial ischemia/reperfusion in rats.
Lv D, Cheng X, Tang L, Jiang M.
Biomed Pharmacother. 2017 Apr;88:277-284. doi: 10.1016/j.biopha.2017.01.060. Epub 2017 Jan 19.

BAY 11-7082 inhibits the NF-κB and NLRP3 inflammasome pathways and protects against IMQ-induced psoriasis.
Irrera N, Vaccaro M, Bitto A, Pallio G, Pizzino G, Lentini M, Arcoraci V, Minutoli L, Scuruchi M, Cutroneo G, Anastasi GP, Ettari R, Squadrito F, Altavilla D.
Clin Sci (Lond). 2017 Mar 1;131(6):487-498. doi: 10.1042/CS20160645. Epub 2017 Jan 17.

IL-6 promotes M2 macrophage polarization by modulating purinergic signaling and regulates the lethal release of nitric oxide during Trypanosoma cruzi infection.
Sanmarco LM, Ponce NE, Visconti LM, Eberhardt N, Theumer MG, Minguez ÁR, Aoki MP.
Biochim Biophys Acta Mol Basis Dis. 2017 Apr;1863(4):857-869. doi: 10.1016/j.bbadis.2017.01.006. Epub 2017 Jan 11.

Differences in Inflammatory Response Induced by Two Representatives of Clades of the Pandemic ST258 Klebsiella pneumoniae Clonal Lineage Producing KPC-Type Carbapenemases.
Castronovo G, Clemente AM, Antonelli A, D’Andrea MM, Tanturli M, Perissi E, Paccosi S, Parenti A, Cozzolino F, Rossolini GM, Torcia MG.
PLoS One. 2017 Jan 12;12(1):e0170125. doi: 10.1371/journal.pone.0170125. eCollection 2017.

Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice.
Jonscher KR, Stewart MS, Alfonso-Garcia A, DeFelice BC, Wang XX, Luo Y, Levi M, Heerwagen MJ, Janssen RC, de la Houssaye BA, Wiitala E, Florey G, Jonscher RL, Potma
EO, Fiehn O, Friedman JE.
FASEB J. 2017 Apr;31(4):1434-1448. doi: 10.1096/fj.201600906R. Epub 2016 Dec 22.

Mangiferin inhibits mastitis induced by LPS via suppressing NF-ĸB and NLRP3 signaling pathways.
Qu S, Wang W, Li D, Li S, Zhang L, Fu Y, Zhang N.
Int Immunopharmacol. 2017 Feb;43:85-90. doi: 10.1016/j.intimp.2016.11.036. Epub 2016 Dec 14.

Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo.
Bitzer ZT, Wopperer AL, Chrisfield BJ, Tao L, Cooper TK, Vanamala J, Elias RJ, Hayes JE, Lambert JD.
J Nutr Biochem. 2017 Feb;40:201-208. doi: 10.1016/j.jnutbio.2016.11.012. Epub 2016 Nov 27.

Potentiation of hepatic stellate cell activation by extracellular ATP is dependent on P2X7R-mediated NLRP3 inflammasome activation.
Jiang S, Zhang Y, Zheng JH, Li X, Yao YL, Wu YL, Song SZ, Sun P, Nan JX, Lian LH.
Pharmacol Res. 2017 Mar;117:82-93. doi: 10.1016/j.phrs.2016.11.040. Epub 2016 Dec 8.

Defective production of interleukin-1 beta in patients with type 2 diabetes mellitus: Restoration by proper glycemic control.
Kousathana F, Georgitsi M, Lambadiari V, Giamarellos-Bourboulis EJ, Dimitriadis G, Mouktaroudi M.
Cytokine. 2017 Feb;90:177-184. doi: 10.1016/j.cyto.2016.11.009. Epub 2016 Dec 3.

Nlrp3 Activation Induces Il-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes.
Maroni L, Agostinelli L, Saccomanno S, Pinto C, Giordano DM, Rychlicki C, De Minicis S, Trozzi L, Banales JM, Melum E, Karlsen TH, Benedetti A, Baroni GS, Marzioni M.
Am J Pathol. 2017 Feb;187(2):366-376. doi: 10.1016/j.ajpath.2016.10.010. Epub 2016 Nov 30.

Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1-Dependent Pathway: Implications for Fetal Growth Restriction.
Brien ME, Duval C, Palacios J, Boufaied I, Hudon-Thibeault AA, Nadeau-Vallée M, Vaillancourt C, Sibley CP, Abrahams VM, Jones RL, Girard S.
J Immunol. 2017 Jan 1;198(1):443-451. Epub 2016 Nov 30.

NLRP3 inflammasome may regulate inflammatory response of human periodontal ligament fibroblasts in an apoptosis-associated speck-like protein containing a CARD (ASC)-dependent manner.
Lu WL, Song DZ, Yue JL, Wang TT, Zhou XD, Zhang P, Zhang L, Huang DM.
Int Endod J. 2017 Oct;50(10):967-975. doi: 10.1111/iej.12722. Epub 2017 Jan 6.

L5-LDL from ST-elevation myocardial infarction patients induces IL-1β production via LOX-1 and NLRP3 inflammasome activation in macrophages.
Yang TC, Chang PY, Lu SC.
Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H265-H274. doi: 10.1152/ajpheart.00509.2016. Epub 2016 Nov 18.

Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.
Tima HG, Al Dulayymi JR, Denis O, Lehebel P, Baols KS, Mohammed MO, L’Homme L, Sahb MM, Potemberg G, Legrand S, Lang R, Beyaert R, Piette J, Baird MS, Huygen
K, Romano M.
J Innate Immun. 2017;9(2):162-180. doi: 10.1159/000450955. Epub 2016 Nov 18.

A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis.
Gomez-Lopez N, Romero R, Xu Y, Plazyo O, Unkel R, Than NG, Chaemsaithong P, Chaiworapongsa T, Dong Z, Tarca AL, Abrahams VM, Yeo L, Hassan SS.
Reprod Sci. 2017 Jun;24(6):934-953. doi: 10.1177/1933719116675058. Epub 2016 Nov 16.

Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts.
Sokolova M, Vinge LE, Alfsnes K, Olsen MB, Eide L, Kaasbøll OJ, Attramadal H, Torp MK, Fosshaug LE, Rashidi A, Lien E, Finsen AV, Sandanger Ø, Aukrust P, Ranheim T, Yndestad A.
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Feb;1862(2):234-245. doi: 10.1016/j.bbalip.2016.11.003. Epub 2016 Nov 12. 

Structural characterization and macrophage immunomodulatory activity of a novel polysaccharide from Smilax glabra Roxb.
Wang M, Yang XB, Zhao JW, Lu CJ, Zhu W.
Carbohydr Polym. 2017 Jan 20;156:390-402. doi: 10.1016/j.carbpol.2016.09.033. Epub 2016 Sep 13.

Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via Adenosine.
Birnbaum Y, Birnbaum GD, Birnbaum I, Nylander S, Ye Y.
Cardiovasc Drugs Ther. 2016 Dec;30(6):539-550.

Hyperin protects against LPS-induced acute kidney injury by inhibiting TLR4 and NLRP3 signaling pathways.
Chunzhi G, Zunfeng L, Chengwei Q, Xiangmei B, Jingui Y.
Oncotarget. 2016 Dec 13;7(50):82602-82608. doi: 10.18632/oncotarget.13010.

HMGB1 Induces an Inflammatory Response in the Chorioamniotic Membranes That Is Partially Mediated by the Inflammasome.
Plazyo O, Romero R, Unkel R, Balancio A, Mial TN, Xu Y, Dong Z, Hassan SS, Gomez-Lopez N.
Biol Reprod. 2016 Dec;95(6):130. doi: 10.1095/biolreprod.116.144139. Epub 2016 Nov 2.

Interleukin 6 receptor inhibitor tocilizumab suppresses cytokine expression, inflammasome activation and phagocytosis in a cell model of sepsis.
Sheng F, Han M, Huang Z, Zhang L.
Pharmazie. 2016 Nov 2;71(11):636-639. doi: 10.1691/ph.2016.6713. 

Protective Effect of Yinhua Miyanling Tablet on Lipopolysaccharide-Induced Inflammation through Suppression of NLRP3/Caspase-1 Inflammasome in Human Peripheral Blood Mononuclear Cells.
Sai J, Xiong L, Zheng J, Liu C, Lu Y, Wang G, Wang Y, Wang T, Guan X, Chen F, Fang K, Zhang C, Lu J, Zhang X, Zhu H, Wang F.
Evid Based Complement Alternat Med. 2016;2016:2758140. Epub 2016 Oct 3.

Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1β/IL-1R1/MyD88/NF-κB pathway.
Song C, He L, Zhang J, Ma H, Yuan X, Hu G, Tao L, Zhang J, Meng J.
J Cell Mol Med. 2016 Nov;20(11):2064-2077. doi: 10.1111/jcmm.12898. Epub 2016 Jun 16.

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly.
Cattaneo A, Cattane N, Galluzzi S, Provasi S, Lopizzo N, Festari C, Ferrari C, Guerra UP, Paghera B, Muscio C, Bianchetti A, Volta GD, Turla M, Cotelli MS, Gennuso M, Prelle A, Zanetti O, Lussignoli G, Mirabile D, Bellandi D, Gentile S, Belotti G, Villani D, Harach T, Bolmont T, Padovani A, Boccardi M, Frisoni GB; INDIA-FBP Group.
Neurobiol Aging. 2017 Jan;49:60-68. doi: 10.1016/j.neurobiolaging.2016.08.019. Epub 2016 Aug 31. 

Ginsenoside Rb1 and compound K improve insulin signaling and inhibit ER stress-associated NLRP3inflammasome activation in adipose tissue.
Chen W, Wang J, Luo Y, Wang T, Li X, Li A, Li J, Liu K, Liu B.
J Ginseng Res. 2016 Oct;40(4):351-358. Epub 2015 Nov 27.

Nuciferine Alleviates Renal Injury by Inhibiting Inflammatory Responses in Fructose-Fed Rats.
Wang MX, Zhao XJ, Chen TY, Liu YL, Jiao RQ, Zhang JH, Ma CH, Liu JH, Pan Y, Kong LD.
J Agric Food Chem. 2016 Oct 26;64(42):7899-7910. doi: 10.1021/acs.jafc.6b03031. Epub 2016 Oct 18.

IFN-γ targets macrophage-mediated immune responses toward Staphylococcus aureus.
Greenlee-Wacker MC, Nauseef WM.
J Leukoc Biol. 2017 Mar;101(3):751-758. doi: 10.1189/jlb.4A1215-565RR. Epub 2016 Oct 5.

Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease.
Yamaguchi Y, Kurita-Ochiai T, Kobayashi R, Suzuki T, Ando T.
Inflamm Res. 2017 Jan;66(1):59-65. doi: 10.1007/s00011-016-0992-4. Epub 2016 Sep 24.

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Pancreatic Islets from Zucker Diabetic Fatty Rats.
Mocanu AO, Mulya A, Huang H, Dan O, Schauer PR, Dinischiotu A, Brethauer SA, Kirwan JP.
Obes Surg. 2016 Dec;26(12):3076-3081.

Protective effect of gedunin on TLR-mediated inflammation by modulation of inflammasome activation and cytokine production: Evidence of a multitarget compound.
Borges PV, Moret KH, Raghavendra NM, Maramaldo Costa TE, Monteiro AP, Carneiro AB, Pacheco P, Temerozo JR, Bou-Habib DC, das Graças Henriques M, Penido C.
Pharmacol Res. 2017 Jan;115:65-77. doi: 10.1016/j.phrs.2016.09.015. Epub 2016 Sep 15.

Therapeutic effect of methyl salicylate 2-O-β-d-lactoside on LPS-induced acute lung injury by inhibiting TAK1/NF-kappaB phosphorylation and NLRP3 expression.
Yang S, Yu Z, Yuan T, Wang L, Wang X, Yang H, Sun L, Wang Y, Du G.
Int Immunopharmacol. 2016 Nov;40:219-228. doi: 10.1016/j.intimp.2016.08.041. Epub 2016 Sep 9.

Dipeptidyl peptidase-4 inhibition by Saxagliptin prevents inflammation and renal injury by targeting the Nlrp3/ASC inflammasome.
Birnbaum Y, Bajaj M, Qian J, Ye Y.
BMJ Open Diabetes Res Care. 2016 Aug 4;4(1):e000227. doi: 10.1136/bmjdrc-2016-000227. eCollection 2016.

Complement-induced activation of the cardiac NLRP3 inflammasome in sepsis.
Kalbitz M, Fattahi F, Grailer JJ, Jajou L, Malan EA, Zetoune FS, Huber-Lang M, Russell MW, Ward PA.
FASEB J. 2016 Dec;30(12):3997-4006. Epub 2016 Aug 19.

Caspase-1 inhibition attenuates activation of BV2 microglia induced by LPS-treated RAW264.7 macrophages.
Pan Y, Shen B, Gao Q, Zhu J, Dong J, Zhang L, Zhang Y.
J Biomed Res. 2016 May;30(3):225-33. doi: 10.7555/JBR.30.20150141. Epub 2016 Apr 15.

Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1β Production during Infection.
Mohammadi N, Midiri A, Mancuso G, Patanè F, Venza M, Venza I, Passantino A, Galbo R, Teti G, Beninati C, Biondo C.
PLoS One. 2016 Aug 10;11(8):e0160249. doi: 10.1371/journal.pone.0160249. eCollection 2016.

Baicalin suppresses NLRP3 inflammasome and nuclear factor-kappa B (NF-κB) signaling during Haemophilus parasuis infection.
Fu S, Xu L, Li S, Qiu Y, Liu Y, Wu Z, Ye C, Hou Y, Hu CA.
Vet Res. 2016 Aug 8;47(1):80. doi: 10.1186/s13567-016-0359-4.

TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles).
Xing Y, Cao R, Hu HM.
Cell Death Dis. 2016 Aug 4;7(8):e2322. doi: 10.1038/cddis.2016.206.

Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation.
Samelko L, Landgraeber S, McAllister K, Jacobs J, Hallab NJ.
PLoS One. 2016 Jul 28;11(7):e0160141. doi: 10.1371/journal.pone.0160141. eCollection 2016.

Decreased Whole-Body Fat Mass Produced by Chronic Alcohol Consumption is Associated with Activation of S6K1-Mediated Protein Synthesis and Increased Autophagy in Epididymal White Adipose Tissue.
Crowell KT, Steiner JL, Coleman CS, Lang CH.
Alcohol Clin Exp Res. 2016 Sep;40(9):1832-45. doi: 10.1111/acer.13159. Epub 2016 Jul 27.

Casticin inhibits lipopolysaccharide-induced acute lung injury in mice.
Wang C, Zeng L, Zhang T, Liu J, Wang W.
Eur J Pharmacol. 2016 Oct 15;789:172-178. doi: 10.1016/j.ejphar.2016.07.035. Epub 2016 Jul 21.

NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation.
Li H, Zhang S, Li F, Qin L.
Mol Immunol. 2016 Aug;76:90-7. doi: 10.1016/j.molimm.2016.06.013. Epub 2016 Jul 6.

A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3inflammasome-mediated inflammation and improving insulin signaling.
Healy NP, Kirwan AM, McArdle MA, Holohan K, Nongonierma AB, Keane D, Kelly S, Celkova L, Lyons CL, McGillicuddy FC, Finucane OM, Murray BA, Kelly PM, Brennan L, FitzGerald RJ, Roche HM.
Mol Nutr Food Res. 2016 Nov;60(11):2421-2432. doi: 10.1002/mnfr.201501054. Epub 2016 Sep 8.

Involvement of EGF receptor signaling and NLRP12 inflammasome in fine particulate matter-induced lung inflammation in mice.
Jin Y, Wu W, Zhang W, Zhao Y, Wu Y, Ge G, Ba Y, Guo Q, Gao T, Chi X, Hao H, Wang J, Feng F.
Environ Toxicol. 2017 Apr;32(4):1121-1134. doi: 10.1002/tox.22308. Epub 2016 Jul 5.

Inflammasome activation by cell volume regulation and inflammation-associated hyponatremia: A vicious cycle.
Kim JH, Park JH, Eisenhut M, Yu JW, Shin JI.
Med Hypotheses. 2016 Aug;93:117-21. doi: 10.1016/j.mehy.2016.05.018. Epub 2016 May 18.

FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes.
Duffy EB, Periasamy S, Hunt D, Drake JR, Harton JA.
J Leukoc Biol. 2016 Dec;100(6):1335-1347. Epub 2016 Jun 30.

Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes.
Hasegawa T, Nakashima M, Suzuki Y.
Biochem Biophys Res Commun. 2016 Aug 26;477(3):329-35. doi: 10.1016/j.bbrc.2016.06.106. Epub 2016 Jun 23.

Effect of Cocaine on HIV Infection and Inflammasome Gene Expression Profile in HIV Infected Macrophages.
Atluri VS, Pilakka-Kanthikeel S, Garcia G, Jayant RD, Sagar V, Samikkannu T, Yndart A, Nair M.
Sci Rep. 2016 Jun 20;6:27864. doi: 10.1038/srep27864.

Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells.
Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T.
J Reprod Immunol. 2016 Aug;116:104-12. doi: 10.1016/j.jri.2016.06.001. Epub 2016 Jun 6.

Morin, a dietary bioflavonol suppresses monosodium urate crystal-induced inflammation in an animal model of acute gouty arthritis with reference to NLRP3 inflammasome, hypo-xanthine phospho-ribosyl transferase, and inflammatory mediators.
Dhanasekar C, Rasool M.
Eur J Pharmacol. 2016 Sep 5;786:116-127. doi: 10.1016/j.ejphar.2016.06.005. Epub 2016 Jun 3.

Genipin alleviates LPS-induced acute lung injury by inhibiting NF-κB and NLRP3 signaling pathways.
Zhang A, Wang S, Zhang J, Wu H.
Int Immunopharmacol. 2016 Sep;38:115-9. doi: 10.1016/j.intimp.2016.05.011. Epub 2016 Jun 2.

Juniperus rigida Sieb. extract inhibits inflammatory responses via attenuation of TRIF-dependent signaling and inflammasome activation.
Han JW, Shim DW, Shin WY, Kim MK, Shim EJ, Sun X, Koppula S, Kim TJ, Kang TB, Lee KH.
J Ethnopharmacol. 2016 Aug 22;190:91-9. doi: 10.1016/j.jep.2016.05.059. Epub 2016 May 31.

Epigallocatechin gallate inhibits urate crystals-induced peritoneal inflammation in C57BL/6 mice.
Jhang JJ, Lu CC, Yen GC.
Mol Nutr Food Res. 2016 Oct;60(10):2297-2303. doi: 10.1002/mnfr.201600106. Epub 2016 Jun 16.

Rosmarinic acid inhibits poly(I:C)-induced inflammatory reaction of epidermal keratinocytes.
Zhou MW, Jiang RH, Kim KD, Lee JH, Kim CD, Yin WT, Lee JH.
Life Sci. 2016 Jun 15;155:189-94. doi: 10.1016/j.lfs.2016.05.023. Epub 2016 May 17.

Beneficial impact of intracerebroventricular fractalkine administration on behavioral and biochemical changes induced by prenatal stress in adult rats: Possible role of NLRP3 inflammasome pathway.
Ślusarczyk J, Trojan E, Wydra K, Głombik K, Chamera K, Kucharczyk M, Budziszewska B, Kubera M, Lasoń W, Filip M, Basta-Kaim A.
Biochem Pharmacol. 2016 Aug 1;113:45-56. doi: 10.1016/j.bcp.2016.05.008. Epub 2016 May 17.

Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation.
Liu X, Zhou W, Zhang X, Lu P, Du Q, Tao L, Ding Y, Wang Y, Hu R.
Biochem Pharmacol. 2016 Jul 15;112:37-49. doi: 10.1016/j.bcp.2016.05.002. Epub 2016 May 13.

Association of EGF Receptor and NLRs signaling with Cardiac Inflammation and Fibrosis in Mice Exposed to Fine Particulate Matter.
Jin Y, Wu Z, Wang N, Duan S, Wu Y, Wang J, Wu W, Feng F.
J Biochem Mol Toxicol. 2016 Sep;30(9):429-37. doi: 10.1002/jbt.21806. Epub 2016 May 9.

The novel TLR9 antagonist COV08-0064 protects from ischemia/reperfusion injury in non-steatotic and steatotic mice livers.
Shaker ME, Trawick BN, Mehal WZ.
Biochem Pharmacol. 2016 Jul 15;112:90-101. doi: 10.1016/j.bcp.2016.05.003. Epub 2016 May 6.

Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation.
Furrer A, Hottiger MO, Valaperti A.
Mol Immunol. 2016 Jun;74:47-58. doi: 10.1016/j.molimm.2016.04.009. Epub 2016 May 2.

MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation.
Liu W, Guo W, Hang N, Yang Y, Wu X, Shen Y, Cao J, Sun Y, Xu Q.
Oncotarget. 2016 May 24;7(21):30536-49. doi: 10.18632/oncotarget.8867.

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline.
Fu AK, Hung KW, Yuen MY, Zhou X, Mak DS, Chan IC, Cheung TH, Zhang B, Fu WY, Liew FY, Ip NY.
Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2705-13. doi: 10.1073/pnas.1604032113. Epub 2016 Apr 18.

The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities.
Zhang F, Wang L, Wang JJ, Luo PF, Wang XT, Xia ZF.
Sci Rep. 2016 Apr 7;6:24166. doi: 10.1038/srep24166.

Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome.
Zhang ZT, Du XM, Ma XJ, Zong Y, Chen JK, Yu CL, Liu YG, Chen YC, Zhao LJ, Lu GC.
J Neuroinflammation. 2016 Apr 5;13(1):71. doi: 10.1186/s12974-016-0539-1.

Clinical Characteristics of Patients Carrying the Q703K Variant of the NLRP3 Gene: A 10-year Multicentric National Study.
Naselli A, Penco F, Cantarini L, Insalaco A, Alessio M, Tommasini A, Maggio C, Obici L, Gallizi R, Cimmino M, Signa S, Lucherini OM, Carta S, Caroli F, Martini A, Rubartelli A, Ceccherini I, Gattorno M.
J Rheumatol. 2016 Jun;43(6):1093-100. doi: 10.3899/jrheum.150962. Epub 2016 Apr 1.

Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation.
Souza AC, Bocharov AV, Baranova IN, Vishnyakova TG, Huang YG, Wilkins KJ, Hu X, Street JM, Alvarez-Prats A, Mullick AE, Patterson AP, Remaley AT, Eggerman TL, Yuen PS, Star RA.
Kidney Int. 2016 Apr;89(4):809-22. doi: 10.1016/j.kint.2015.12.043. 

Disease activity accounts for long-term efficacy of IL-1 blockers in pyogenic sterile arthritis pyoderma gangrenosum and severe acne syndrome.
Omenetti A, Carta S, Caorsi R, Finetti M, Marotto D, Lattanzi B, Jorini M, Delfino L, Penco F, Picco P, Buoncompagni A, Martini A, Rubartelli A, Gattorno M.
Rheumatology (Oxford). 2016 Jul;55(7):1325-35. doi: 10.1093/rheumatology/kew031. Epub 2016 Mar 17.

Acute systemic exposure to silver-based nanoparticles induces hepatotoxicity and NLRP3-dependent inflammation.
Ramadi KB, Mohamed YA, Al-Sbiei A, Almarzooqi S, Bashir G, Al Dhanhani A, Sarawathiamma D, Qadri S, Yasin J, Nemmar A, Fernandez-Cabezudo MJ, Haik Y, Al
Ramadi BK.
Nanotoxicology. 2016 Oct;10(8):1061-74. doi: 10.3109/17435390.2016.1163743. Epub 2016 Apr 14.

NLRP3 inflammasome activation contributes to Listeria monocytogenes-induced animal pregnancy failure.
Li W, Chang Y, Liang S, Zhong Z, Li X, Wen J, Zhang Y, Zhang J, Wang L, Lin H, Cao X, Huang H, Zhong F.
BMC Vet Res. 2016 Feb 24;12:36. doi: 10.1186/s12917-016-0655-2.

Upregulation of inflammasome activity and increased gut permeability are associated with obesity in children and adolescents.
Rainone V, Schneider L, Saulle I, Ricci C, Biasin M, Al-Daghri NM, Giani E, Zuccotti GV, Clerici M, Trabattoni D.
Int J Obes (Lond). 2016 Jun;40(6):1026-33. doi: 10.1038/ijo.2016.26. Epub 2016 Feb 15.

A20 overexpression alleviates pristine-induced lupus nephritis by inhibiting the NF-κB and NLRP3inflammasome activation in macrophages of mice.
Li M, Shi X, Qian T, Li J, Tian Z, Ni B, Hao F.
Int J Clin Exp Med. 2015 Oct 15;8(10):17430-40. eCollection 2015.

Withaferin A Inhibits Helicobacter pylori-induced Production of IL-1β in Dendritic Cells by Regulating NF-κB and NLRP3 Inflammasome Activation.
Kim JE, Lee JY, Kang MJ, Jeong YJ, Choi JA, Oh SM, Lee KB, Park JH.
Immune Netw. 2015 Dec;15(6):269-77. doi: 10.4110/in.2015.15.6.269. Epub 2015 Dec 24.

Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression.
Galam L, Rajan A, Failla A, Soundararajan R, Lockey RF, Kolliputi N.
Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15;310(6):L572-81. doi: 10.1152/ajplung.00417.2015. Epub 2016 Jan 8.

CFH Y402H polymorphism and the complement activation product C5a: effects on NF-κB activation and inflammasome gene regulation.
Cao S, Wang JC, Gao J, Wong M, To E, White VA, Cui JZ, Matsubara JA.
Br J Ophthalmol. 2016 May;100(5):713-8. doi: 10.1136/bjophthalmol-2015-307213. Epub 2016 Jan 8.

[The role of Nods like receptors in the patients with allergic rhinitis].
Zhang S, Liu Y, Shen C, Li G, Yang K, Shi X, Wen Z.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Aug;29(15):1323-8. Chinese. 

A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways.
Ka SM, Kuoping Chao L, Lin JC, Chen ST, Li WT, Lin CN, Cheng JC, Jheng HL, Chen A, Hua KF.
Free Radic Biol Med. 2016 Feb;91:10-24. doi: 10.1016/j.freeradbiomed.2015.12.003. Epub 2015 Dec 7.

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3inflammasome and apoptosis signaling.
Dong Y, Fan C, Hu W, Jiang S, Ma Z, Yan X, Deng C, Di S, Xin Z, Wu G, Yang Y, Reiter RJ, Liang G.
J Pineal Res. 2016 Apr;60(3):253-62. doi: 10.1111/jpi.12300. Epub 2016 Feb 15.

The protective effects of curculigoside A on adjuvant-induced arthritis by inhibiting NF-кB/NLRP3activation in rats.
Ding H, Gao G, Zhang L, Shen G, Sun W, Gu Z, Fan W.
Int Immunopharmacol. 2016 Jan;30:43-49. doi: 10.1016/j.intimp.2015.11.026. Epub 2015 Nov 27.

Posttranscriptional control of NLRP3 inflammasome activation in colonic macrophages.
Filardy AA, He J, Bennink J, Yewdell J, Kelsall BL.
Mucosal Immunol. 2016 Jul;9(4):850-8. doi: 10.1038/mi.2015.109. Epub 2015 Dec 2.

Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components.
Boyles MS, Kristl T, Andosch A, Zimmermann M, Tran N, Casals E, Himly M, Puntes V, Huber CG, Lütz-Meindl U, Duschl A.
J Nanobiotechnology. 2015 Nov 18;13:84. doi: 10.1186/s12951-015-0146-9.

Anti-inflammatory properties of Morus bombycis Koidzumi via inhibiting IFN-β signaling and NLRP3inflammasome activation.
Oh NH, Han JW, Shim DW, Sim EJ, Koppula S, Kwak SB, Kim MK, Kim YK, Jiang J, Park PJ, Kang TB, Lee KH.
J Ethnopharmacol. 2015 Dec 24;176:424-8. doi: 10.1016/j.jep.2015.11.022. Epub 2015 Nov 10.

Airborne allergens induce protease activated receptor-2-mediated production of inflammatory cytokines in human gingival epithelium.
Son GY, Son A, Yang YM, Park W, Chang I, Lee JH, Shin DM.
Arch Oral Biol. 2016 Jan;61:138-43. doi: 10.1016/j.archoralbio.2015.10.015. Epub 2015 Oct 31.

Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: A potential mediator between mitochondria and immune-activation.
Kim HK, Andreazza AC, Elmi N, Chen W, Young LT.
J Psychiatr Res. 2016 Jan;72:43-50. doi: 10.1016/j.jpsychires.2015.10.015. Epub 2015 Oct 26.

The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome.
Frank MG, Weber MD, Fonken LK, Hershman SA, Watkins LR, Maier SF.
Brain Behav Immun. 2016 Jul;55:215-224. doi: 10.1016/j.bbi.2015.10.009. Epub 2015 Oct 19.

Effects of Inflammasome Activation on Secretion of Inflammatory Cytokines and Vascular Endothelial Growth Factor by Retinal Pigment Epithelial Cells.
Mohr LK, Hoffmann AV, Brandstetter C, Holz FG, Krohne TU.
Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6404-13. doi: 10.1167/iovs.15-16898.

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats.
Mocanu AO, Mulya A, Huang H, Dan O, Shimizu H, Batayyah E, Brethauer SA, Dinischiotu A, Kirwan JP.
PLoS One. 2015 Oct 5;10(10):e0139764. doi: 10.1371/journal.pone.0139764. eCollection 2015.

NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy.
Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura H, Kawashima A, Ohkuchi A, Taniguchi S, Takahashi M.
Endocrinology. 2015 Nov;156(11):4281-92. doi: 10.1210/en.2015-1408. Epub 2015 Sep 10.

Mitochondrial DNA has a pro-inflammatory role in AMD.
Dib B, Lin H, Maidana DE, Tian B, Miller JB, Bouzika P, Miller JW, Vavvas DG.
Biochim Biophys Acta. 2015 Nov;1853(11 Pt A):2897-906. doi: 10.1016/j.bbamcr.2015.08.012. Epub 2015 Aug 21.

Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome.
Martínez GJ, Robertson S, Barraclough J, Xia Q, Mallat Z, Bursill C, Celermajer DS, Patel S.
J Am Heart Assoc. 2015 Aug 24;4(8):e002128. doi: 10.1161/JAHA.115.002128.

Targeting Interleukin-1 beta to Suppress Sympathoexcitation in Hypothalamic Paraventricular Nucleus in Dahl Salt-Sensitive Hypertensive Rats.
Qi J, Zhao XF, Yu XJ, Yi QY, Shi XL, Tan H, Fan XY, Gao HL, Yue LY, Feng ZP, Kang YM.
Cardiovasc Toxicol. 2016 Jul;16(3):298-306. doi: 10.1007/s12012-015-9338-7.

TLR3 and TLR4 But not TLR2 are Involved in Vogt-Koyanagi- Harada Disease by Triggering Proinflammatory Cytokines Production Through Promoting the Production of Mitochondrial Reactive Oxygen Species.
Liang L, Tan X, Zhou Q, Tian Y, Kijlstra A, Yang P.
Curr Mol Med. 2015;15(6):529-42.

Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation.
Jhang JJ, Lu CC, Ho CY, Cheng YT, Yen GC.
J Agric Food Chem. 2015 Aug 26;63(33):7343-52. doi: 10.1021/acs.jafc.5b02605. Epub 2015 Aug 12.

Cape Gooseberry [Physalis peruviana L.] Calyces Ameliorate TNBS Acid-induced Colitis in Rats.
Castro J, Ocampo Y, Franco L.
J Crohns Colitis. 2015 Nov;9(11):1004-15. doi: 10.1093/ecco-jcc/jjv132. Epub 2015 Jul 27.

Inhibitory effect of Paeonia lactiflora Pallas extract (PE) on poly (I:C)-induced immune response of epidermal keratinocytes.
Choi MR, Choi DK, Sohn KC, Lim SK, Kim DI, Lee YH, Im M, Lee Y, Seo YJ, Kim CD, Lee JH.
Int J Clin Exp Pathol. 2015 May 1;8(5):5236-41. eCollection 2015.

A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein.
Sánchez Vallecillo MF, Minguito de la Escalera MM, Aguirre MV, Ullio Gamboa GV, Palma SD, González-Cintado L, Chiodetti AL, Soldano G, Morón G, Allemandi DA,
Ardavín C, Pistoresi-Palencia MC, Maletto BA.
J Control Release. 2015 Sep 28;214:12-22. doi: 10.1016/j.jconrel.2015.07.008. Epub 2015 Jul 15.

Nitric Oxide-Releasing Nanoparticles Prevent Propionibacterium acnes-Induced Inflammation by Both Clearing the Organism and Inhibiting Microbial Stimulation of the Innate Immune Response.
Qin M, Landriscina A, Rosen JM, Wei G, Kao S, Olcott W, Agak GW, Paz KB, Bonventre J, Clendaniel A, Harper S, Adler BL, Krausz AE, Friedman JM, Nosanchuk JD, Kim J,
Friedman AJ.
J Invest Dermatol. 2015 Nov;135(11):2723-2731. doi: 10.1038/jid.2015.277. Epub 2015 Jul 14. 

Is interleukin-1β a culprit in macrophage-adipocyte crosstalk in obesity?
Bing C.
Adipocyte. 2015 Jan 7;4(2):149-52. doi: 10.4161/21623945.2014.979661. eCollection 2015 Apr-Jun.

Unified Modeling of Familial Mediterranean Fever and Cryopyrin Associated Periodic Syndromes.
Bozkurt Y, Demir A, Erman B, Gül A.
Comput Math Methods Med. 2015;2015:893507. doi: 10.1155/2015/893507. Epub 2015 May 28.

A Dual Role for P2X7 Receptor during Porphyromonas gingivalis Infection.
Ramos-Junior ES, Morandini AC, Almeida-da-Silva CL, Franco EJ, Potempa J, Nguyen KA, Oliveira AC, Zamboni DS, Ojcius DM, Scharfstein J, Coutinho-Silva R.
J Dent Res. 2015 Sep;94(9):1233-42. doi: 10.1177/0022034515593465. Epub 2015 Jul 7.

IL-1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages.
Gicquel T, Robert S, Loyer P, Victoni T, Bodin A, Ribault C, Gleonnec F, Couillin I, Boichot E, Lagente V.
FASEB J. 2015 Oct;29(10):4162-73. doi: 10.1096/fj.14-267393. Epub 2015 Jun 26.

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice.
Krishnan SM, Dowling JK, Ling YH, Diep H, Chan CT, Ferens D, Kett MM, Pinar A, Samuel CS, Vinh A, Arumugam TV, Hewitson TD, Kemp-Harper BK, Robertson AA,
Cooper MA, Latz E, Mansell A, Sobey CG, Drummond GR.
Br J Pharmacol. 2016 Feb;173(4):752-65. doi: 10.1111/bph.13230. Epub 2015 Jul 31.

Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3Inflammasome.
Shao A, Wu H, Hong Y, Tu S, Sun X, Wu Q, Zhao Q, Zhang J, Sheng J.
Mol Neurobiol. 2016 Jul;53(5):3462-3476. doi: 10.1007/s12035-015-9242-y. Epub 2015 Jun 20.

A critical role for hemolysin in Vibrio fluvialis-induced IL-1β secretion mediated by the NLRP3inflammasome in macrophages.
Song L, Huang Y, Zhao M, Wang Z, Wang S, Sun H, Kan B, Meng G, Liang W, Ren Z.
Front Microbiol. 2015 May 22;6:510. doi: 10.3389/fmicb.2015.00510. eCollection 2015.

Expanding spectrum of neurologic manifestations in patients with NLRP3 low-penetrance mutations.
Schuh E, Lohse P, Ertl-Wagner B, Witt M, Krumbholz M, Frankenberger M, Gerdes LA, Hohlfeld R, Kümpfel T.
Neurol Neuroimmunol Neuroinflamm. 2015 May 14;2(4):e109. doi: 10.1212/NXI.0000000000000109. eCollection 2015 Aug.

CD47 Promotes Protective Innate and Adaptive Immunity in a Mouse Model of Disseminated Candidiasis.
Navarathna DH, Stein EV, Lessey-Morillon EC, Nayak D, Martin-Manso G, Roberts DD.
PLoS One. 2015 May 26;10(5):e0128220. doi: 10.1371/journal.pone.0128220. eCollection 2015.

Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes.
Lee HJ, Hong YS, Jun W, Yang SJ.
J Med Food. 2015 Nov;18(11):1207-13. doi: 10.1089/jmf.2015.3439. Epub 2015 May 14.

Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice.
Deng XY, Li HY, Chen JJ, Li RP, Qu R, Fu Q, Ma SP.
Behav Brain Res. 2015 Sep 15;291:12-19. doi: 10.1016/j.bbr.2015.04.052. Epub 2015 May 6.

Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury.
Deutsch M, Graffeo CS, Rokosh R, Pansari M, Ochi A, Levie EM, Van Heerden E, Tippens DM, Greco S, Barilla R, Tomkötter L, Zambirinis CP, Avanzi N, Gulati R, Pachter HL, Torres-Hernandez A, Eisenthal A, Daley D, Miller G.
Cell Death Dis. 2015 May 7;6:e1759. doi: 10.1038/cddis.2015.126.

CD36/SR-B2-TLR2 Dependent Pathways Enhance Porphyromonas gingivalis Mediated Atherosclerosis in the Ldlr KO Mouse Model.
Brown PM, Kennedy DJ, Morton RE, Febbraio M.
PLoS One. 2015 May 4;10(5):e0125126. doi: 10.1371/journal.pone.0125126. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0130245

L-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmitters.
Xue J, Li H, Deng X, Ma Z, Fu Q, Ma S.
Pharmacol Biochem Behav. 2015 Jul;134:42-8. doi: 10.1016/j.pbb.2015.04.014. Epub 2015 Apr 29.

Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium.
Zhao Y, Li Q, Zhao W, Li J, Sun Y, Liu K, Liu B, Zhang N.
J Ethnopharmacol. 2015 Jul 1;169:210-8. doi: 10.1016/j.jep.2015.04.030. Epub 2015 Apr 25.

Role of the NLRP3 inflammasome in the transient release of IL-1β induced by monosodium urate crystals in human fibroblast-like synoviocytes.
Zheng SC, Zhu XX, Xue Y, Zhang LH, Zou HJ, Qiu JH, Liu Q.
J Inflamm (Lond). 2015 Apr 10;12:30. doi: 10.1186/s12950-015-0070-7. eCollection 2015.

Toxin-induced necroptosis is a major mechanism of Staphylococcus aureus lung damage.
Kitur K, Parker D, Nieto P, Ahn DS, Cohen TS, Chung S, Wachtel S, Bueno S, Prince A.
PLoS Pathog. 2015 Apr 16;11(4):e1004820. doi: 10.1371/journal.ppat.1004820. eCollection 2015 Apr.

Sintered indium-tin oxide particles induce pro-inflammatory responses in vitro, in part through inflammasome activation.
Badding MA, Schwegler-Berry D, Park JH, Fix NR, Cummings KJ, Leonard SS.
PLoS One. 2015 Apr 13;10(4):e0124368. doi: 10.1371/journal.pone.0124368. eCollection 2015.

Oral Infections, Metabolic Inflammation, Genetics, and Cardiometabolic Diseases.
Janket SJ, Javaheri H, Ackerson LK, Ayilavarapu S, Meurman JH.
J Dent Res. 2015 Sep;94(9 Suppl):119S-27S. doi: 10.1177/0022034515580795. Epub 2015 Apr 3. Review.

Fish-oil-derived n-3 PUFAs reduce inflammatory and chemotactic adipokine-mediated cross-talk between co-cultured murine splenic CD8+ T cells and adipocytes.
Monk JM, Liddle DM, De Boer AA, Brown MJ, Power KA, Ma DW, Robinson LE.
J Nutr. 2015 Apr;145(4):829-38. doi: 10.3945/jn.114.205443. Epub 2015 Feb 4.

Apelin inhibits the activation of the nucleotide-binding domain and the leucine-rich, repeat-containing family, pyrin-containing 3 (NLRP3) inflammasome and ameliorates insulin resistance in severely burned rats.
Chi Y, Chai J, Xu C, Luo H, Zhang Q.
Surgery. 2015 Jun;157(6):1142-52. doi: 10.1016/j.surg.2015.01.011. Epub 2015 Mar 25.

Cell-penetrating peptide derived from human eosinophil cationic protein inhibits mite allergen Der p 2 induced inflammasome activation.
Yu SJ, Liao EC, Sheu ML, Chang DT, Tsai JJ.
PLoS One. 2015 Mar 25;10(3):e0121393. doi: 10.1371/journal.pone.0121393. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0127255

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK.
Li Y, Li J, Li S, Li Y, Wang X, Liu B, Fu Q, Ma S.
Toxicol Appl Pharmacol. 2015 Jul 1;286(1):53-63. doi: 10.1016/j.taap.2015.03.010. Epub 2015 Mar 16.

Differential regulation of proinflammatory mediators following LPS- and ATP-induced activation of monocytes from patients with antiphospholipid syndrome.
Martirosyan A, Petrek M, Navratilova Z, Blbulyan A, Boyajyan A, Manukyan G.
Biomed Res Int. 2015;2015:292851. doi: 10.1155/2015/292851. Epub 2015 Feb 15.

Syneilesis palmata (Thunb.) Maxim. extract attenuates inflammatory responses via the regulation of TRIF-dependent signaling and inflammasome activation.
Han JW, Shim DW, Shim EJ, Kim MK, Shin YK, Kwak SB, Koppula S, Kim TJ, Kang TB, Lee KH.
J Ethnopharmacol. 2015 May 26;166:1-4. doi: 10.1016/j.jep.2015.02.056. Epub 2015 Mar 6.

Aggregatibacter actinomycetemcomitans induces Th17 cells in atherosclerotic lesions.
Jia R, Hashizume-Takizawa T, Du Y, Yamamoto M, Kurita-Ochiai T.
Pathog Dis. 2015 Apr;73(3). pii: ftu027. doi: 10.1093/femspd/ftu027. Epub 2015 Jan 28.

Temporal regulation of cytokine mRNA expression by tristetraprolin: dynamic control by p38 MAPK and MKP-1.
Prabhala P, Bunge K, Rahman MM, Ge Q, Clark AR, Ammit AJ.
Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L973-80. doi: 10.1152/ajplung.00219.2014. Epub 2015 Feb 27.

A novel synthetic derivative of melatonin, 5-hydroxy-2′-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation.
Shim DW, Shin HJ, Han JW, Ji YE, Jang CH, Koppula S, Kang TB, Lee KH.
Toxicol Appl Pharmacol. 2015 Apr 15;284(2):227-35. doi: 10.1016/j.taap.2015.02.006. Epub 2015 Feb 14.

Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation.
Sun Y, Zhao Y, Yao J, Zhao L, Wu Z, Wang Y, Pan D, Miao H, Guo Q, Lu N.
Biochem Pharmacol. 2015 Mar 15;94(2):142-54. doi: 10.1016/j.bcp.2015.02.002. Epub 2015 Feb 10.

Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3inflammasome in human macrophages, leading to the release of proinflammatory cytokines.
Shenker BJ, Ojcius DM, Walker LP, Zekavat A, Scuron MD, Boesze-Battaglia K.
Infect Immun. 2015 Apr;83(4):1487-96. doi: 10.1128/IAI.03132-14. Epub 2015 Feb 2.

Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet.
Abderrazak A, Couchie D, Mahmood DF, Elhage R, Vindis C, Laffargue M, Matéo V, Büchele B, Ayala MR, El Gaafary M, Syrovets T, Slimane MN, Friguet B, Fulop T, Simmet T, El Hadri K, Rouis M.
Circulation. 2015 Mar 24;131(12):1061-70. doi: 10.1161/CIRCULATIONAHA.114.013730. Epub 2015 Jan 22.

Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases.
Cleophas MC, Crişan TO, Lemmers H, Toenhake-Dijkstra H, Fossati G, Jansen TL, Dinarello CA, Netea MG, Joosten LA.
Ann Rheum Dis. 2016 Mar;75(3):593-600. doi: 10.1136/annrheumdis-2014-206258. Epub 2015 Jan 14.

Peroxyauraptenol Inhibits Inflammation and NLRP3 Inflammasome Activation by Inhibiting Reactive Oxygen Species Generation and Preserving Mitochondrial Integrity.
Chao LK, Lin CH, Chiu HW, Wong WT, Chiu HW, Tasi YL, Kuo YH, Chiu YC, Liu ML, Ho CL, Hua KF.
J Agric Food Chem. 2015 Feb 4;63(4):1210-1219. doi: 10.1021/jf5054436. Epub 2015 Jan 22.

Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation.
Guo W, Liu W, Jin B, Geng J, Li J, Ding H, Wu X, Xu Q, Sun Y, Gao J.
Int Immunopharmacol. 2015 Feb;24(2):232-238. doi: 10.1016/j.intimp.2014.12.009. Epub 2014 Dec 15.

Essential oil from the heartwood of Taiwan fir ameliorates LPS-induced inflammatory response by inhibiting the activation of mitogen-activated protein kinase.
Liu ML, Hua KF, Yang TJ, Chiu HW, Ho CL.
Nat Prod Commun. 2014 Oct;9(10):1519-22.

Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3inflammasome activation with regulation of AMPK in endothelial cells.
Song J, Li J, Hou F, Wang X, Liu B.
Metabolism. 2015 Mar;64(3):428-37. doi: 10.1016/j.metabol.2014.11.008. Epub 2014 Nov 28.

Muramyl dipeptide activates human beta defensin 2 and pro-inflammatory mediators through Toll-like receptors and NLRP3 inflammasomes in human dental pulp cells.
Lee SI, Kang SK, Jung HJ, Chun YH, Kwon YD, Kim EC.
Clin Oral Investig. 2015 Jul;19(6):1419-28. doi: 10.1007/s00784-014-1361-8. Epub 2014 Dec 3.

Methylsulfonylmethane inhibits NLRP3 inflammasome activation.
Ahn H, Kim J, Lee MJ, Kim YJ, Cho YW, Lee GS.
Cytokine. 2015 Feb;71(2):223-31. doi: 10.1016/j.cyto.2014.11.001. Epub 2014 Nov 21.

Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone.
Wu XF, Ouyang ZJ, Feng LL, Chen G, Guo WJ, Shen Y, Wu XD, Sun Y, Xu Q.
Toxicol Appl Pharmacol. 2014 Nov 15;281(1):146-56. doi: 10.1016/j.taap.2014.10.002. Epub 2014 Oct 13.

Glucose and metformin modulate human first trimester trophoblast function: a model and potential therapy for diabetes-associated uteroplacental insufficiency.
Han CS, Herrin MA, Pitruzzello MC, Mulla MJ, Werner EF, Pettker CM, Flannery CA, Abrahams VM.
Am J Reprod Immunol. 2015 Apr;73(4):362-71. doi: 10.1111/aji.12339. Epub 2014 Nov 14.

Procyanidin B2 inhibits inflammasome-mediated IL-1β production in lipopolysaccharide-stimulated macrophages.
Martinez-Micaelo N, González-Abuín N, Pinent M, Ardévol A, Blay M.
Mol Nutr Food Res. 2015 Feb;59(2):262-9. doi: 10.1002/mnfr.201400370. Epub 2014 Dec 5.

Iron, inflammation, and early death in adults with sickle cell disease.
van Beers EJ, Yang Y, Raghavachari N, Tian X, Allen DT, Nichols JS, Mendelsohn L, Nekhai S, Gordeuk VR, Taylor JG 6th, Kato GJ.
Circ Res. 2015 Jan 16;116(2):298-306. doi: 10.1161/CIRCRESAHA.116.304577. Epub 2014 Nov 6.

Flavonoid apigenin inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in macrophages.
Zhang X, Wang G, Gurley EC, Zhou H.
PLoS One. 2014 Sep 5;9(9):e107072. doi: 10.1371/journal.pone.0107072. eCollection 2014.

Synthesis, characterization, and bioactivity of carboxylic acid-functionalized titanium dioxide nanobelts.
Hamilton RF, Wu N, Xiang C, Li M, Yang F, Wolfarth M, Porter DW, Holian A.
Part Fibre Toxicol. 2014 Sep 2;11:43. doi: 10.1186/s12989-014-0043-7.

Inhibition of the nucleotide-binding domain, leucine-rich containing family, pyrin-domain containing 3 inflammasome reduces the severity of experimentally induced acute pancreatitis in obese mice.
York JM, Castellanos KJ, Cabay RJ, Fantuzzi G.
Transl Res. 2014 Oct;164(4):259-69. doi: 10.1016/j.trsl.2014.06.012. Epub 2014 Aug 15.

The inflammasome in alcoholic hepatitis: Its relationship with Mallory-Denk body formation.
Peng Y, French BA, Tillman B, Morgan TR, French SW.
Exp Mol Pathol. 2014 Oct;97(2):305-13. doi: 10.1016/j.yexmp.2014.08.006. Epub 2014 Aug 19.

Limited role for ASC and NLRP3 during in vivo Salmonella Typhimurium infection.
De Jong HK, Koh GC, van Lieshout MH, Roelofs JJ, van Dissel JT, van der Poll T, Wiersinga WJ.
BMC Immunol. 2014 Aug 13;15:30. doi: 10.1186/s12865-014-0030-7.

Essential oil from leaves of Liquidambar formosana ameliorates inflammatory response in lipopolysaccharide-activated mouse macrophages.
Hua KF, Yang TJ, Chiu HW, Ho CL.
Nat Prod Commun. 2014 Jun;9(6):869-72.

Cholesterol crystals induce inflammatory cytokines expression in a human retinal pigment epithelium cell line by activating the NF-κB pathway.
Hu Y, Lin H, Dib B, Atik A, Bouzika P, Lin C, Yan Y, Tang S, Miller JW, Vavvas DG.
Discov Med. 2014 Jul-Aug;18(97):7-14.

Role of lysosomes in silica-induced inflammasome activation and inflammation in absence of MARCO.
Biswas R, Hamilton RF Jr, Holian A.
J Immunol Res. 2014;2014:304180. doi: 10.1155/2014/304180. Epub 2014 Jun 26.

Production of IL-1β by bone marrow-derived macrophages in response to chemotherapeutic drugs: synergistic effects of doxorubicin and vincristine.
Wong J, Tran LT, Magun EA, Magun BE, Wood LJ.
Cancer Biol Ther. 2014 Oct;15(10):1395-403. doi: 10.4161/cbt.29922. Epub 2014 Jul 21.

Vinpocetine inhibits amyloid-beta induced activation of NF-κB, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells.
Liu RT, Wang A, To E, Gao J, Cao S, Cui JZ, Matsubara JA.
Exp Eye Res. 2014 Oct;127:49-58. doi: 10.1016/j.exer.2014.07.003. Epub 2014 Jul 17.

Chemical composition and anti-inflammatory activity of Chamaecyparis obtusa f.formosana wood essential oil from Taiwan.
Chien TC, Lo SF, Ho CL.
Nat Prod Commun. 2014 May;9(5):723-6.

Porcine reproductive and respiratory syndrome virus infection activates NOD2-RIP2 signal pathway in MARC-145 cells.
Jing H, Fang L, Wang D, Ding Z, Luo R, Chen H, Xiao S.
Virology. 2014 Jun;458-459:162-71. doi: 10.1016/j.virol.2014.04.031. Epub 2014 May 13.

The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-κB, pyrin-only protein 4.
Porter KA, Duffy EB, Nyland P, Atianand MK, Sharifi H, Harton JA.
Genes Immun. 2014 Sep;15(6):392-403. doi: 10.1038/gene.2014.30. Epub 2014 May 29.

Anti-inflammatory therapies for cardiovascular disease.
Ridker PM, Lüscher TF.
Eur Heart J. 2014 Jul 14;35(27):1782-91. doi: 10.1093/eurheartj/ehu203. Epub 2014 May 26. Review.

The effects of morin on lipopolysaccharide-induced acute lung injury by suppressing the lung NLRP3inflammasome.
Tianzhu Z, Shihai Y, Juan D.
Inflammation. 2014 Dec;37(6):1976-83. doi: 10.1007/s10753-014-9930-1.

Impaired cytokine responses in patients with cryopyrin-associated periodic syndrome (CAPS).
Haverkamp MH, van de Vosse E, Goldbach-Mansky R, Holland SM.
Clin Exp Immunol. 2014 Sep;177(3):720-31. doi: 10.1111/cei.12361.

Clinical and genetic characterization of Japanese sporadic cases of periodic Fever, aphthous stomatitis, pharyngitis and adenitis syndrome from a single medical center in Japan.
Kubota K, Ohnishi H, Teramoto T, Kawamoto N, Kasahara K, Ohara O, Kondo N.
J Clin Immunol. 2014 Jul;34(5):584-93. doi: 10.1007/s10875-014-0043-2. Epub 2014 Apr 24.

Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion.
Wang CP, Zhang LZ, Li GC, Shi YW, Li JL, Zhang XC, Wang ZW, Ding F, Liang XM.
J Neurosci Res. 2014 Jul;92(7):944-54. doi: 10.1002/jnr.23374. Epub 2014 Mar 31.

Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation.
Yang SJ, Lim Y.
Metabolism. 2014 May;63(5):693-701. doi: 10.1016/j.metabol.2014.02.003. Epub 2014 Feb 11.

Berberine prevents damage to the intestinal mucosal barrier during early phase of sepsis in rat through mechanisms independent of the NOD-like receptors signaling pathway.
Li GX, Wang XM, Jiang T, Gong JF, Niu LY, Li N.
Eur J Pharmacol. 2014 May 5;730:1-7. doi: 10.1016/j.ejphar.2014.02.006. Epub 2014 Feb 14.

Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus.
Frank MG, Hershman SA, Weber MD, Watkins LR, Maier SF.
Psychoneuroendocrinology. 2014 Feb;40:191-200. doi: 10.1016/j.psyneuen.2013.11.006. Epub 2013 Nov 27.

Critical role for the AIM2 inflammasome during acute CNS bacterial infection.
Hanamsagar R, Aldrich A, Kielian T.
J Neurochem. 2014 May;129(4):704-11. doi: 10.1111/jnc.12669. Epub 2014 Feb 19.

Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses.
Bulau AM, Nold MF, Li S, Nold-Petry CA, Fink M, Mansell A, Schwerd T, Hong J, Rubartelli A, Dinarello CA, Bufler P.
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2650-5. doi: 10.1073/pnas.1324140111. Epub 2014 Jan 30.

Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.
Gicquel T, Victoni T, Fautrel A, Robert S, Gleonnec F, Guezingar M, Couillin I, Catros V, Boichot E, Lagente V.
Clin Exp Pharmacol Physiol. 2014 Apr;41(4):279-86. doi: 10.1111/1440-1681.12214.

Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD.
Di Stefano A, Caramori G, Barczyk A, Vicari C, Brun P, Zanini A, Cappello F, Garofano E, Padovani A, Contoli M, Casolari P, Durham AL, Chung KF, Barnes PJ, Papi A,
Adcock I, Balbi B.
Thorax. 2014 Jun;69(6):516-24. doi: 10.1136/thoraxjnl-2012-203062. Epub 2014 Jan 15.

The complex P2X7 receptor/inflammasome in perivascular fat tissue of heavy smokers.
Rossi C, Santini E, Chiarugi M, Salvati A, Comassi M, Vitolo E, Madec S, Solini A.
Eur J Clin Invest. 2014;44(3):295-302. doi: 10.1111/eci.12232. Epub 2014 Jan 20.

Cationic lipid nanocarriers activate Toll-like receptor 2 and NLRP3 inflammasome pathways.
Lonez C, Bessodes M, Scherman D, Vandenbranden M, Escriou V, Ruysschaert JM.
Nanomedicine. 2014 May;10(4):775-82. doi: 10.1016/j.nano.2013.12.003. Epub 2013 Dec 20.

TLR4 and NLRP3 inflammasome activation in monocytes by N-propionyl cysteaminylphenol-maleimide-dextran (NPCMD).
Mizote Y, Wakamatsu K, Ito S, Uenaka A, Ohue Y, Kurose K, Isobe M, Ito A, Tamura Y, Honda H, Yamashita T, Nohara S, Oka M, Jimbow K, Nakayama E.
J Dermatol Sci. 2014 Mar;73(3):209-15. doi: 10.1016/j.jdermsci.2013.11.006. Epub 2013 Nov 14. 

Leptin enhances the secretion of interleukin (IL)-18, but not IL-1β, from human monocytes via activation of caspase-1.
Jitprasertwong P, Jaedicke KM, Nile CJ, Preshaw PM, Taylor JJ.
Cytokine. 2014 Feb;65(2):222-30. doi: 10.1016/j.cyto.2013.10.008. Epub 2013 Nov 23.

Inhibition of the NF-κB pathway as a candidate therapeutic strategy for cryopyrin-associated periodic syndrome.
Shimogaki S, Ito S, Komatsu S, Koike R, Miyasaka N, Umezawa K, Kubota T.
Mod Rheumatol. 2014 May;24(3):517-24. doi: 10.3109/14397595.2013.844298. Epub 2013 Nov 4.

Effect of MWCNT size, carboxylation, and purification on in vitro and in vivo toxicity, inflammation and lung pathology.
Hamilton RF Jr, Wu Z, Mitra S, Shaw PK, Holian A.
Part Fibre Toxicol. 2013 Nov 13;10(1):57. doi: 10.1186/1743-8977-10-57.

Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10.
Murphy N, Grehan B, Lynch MA.
Neuromolecular Med. 2014 Mar;16(1):205-15. doi: 10.1007/s12017-013-8274-6. Epub 2013 Nov 7.

The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals.
Wikstrom ME, Khong A, Fleming P, Kuns R, Hertzog PJ, Frazer IH, Andoniou CE, Hill GR, Degli-Esposti MA.
Eur J Immunol. 2014 Feb;44(2):409-19. doi: 10.1002/eji.201243109. Epub 2013 Dec 16.

Bamboo vinegar decreases inflammatory mediator expression and NLRP3 inflammasome activation by inhibiting reactive oxygen species generation and protein kinase C-α/δ activation.
Ho CL, Lin CY, Ka SM, Chen A, Tasi YL, Liu ML, Chiu YC, Hua KF.
PLoS One. 2013 Oct 4;8(10):e75738. doi: 10.1371/journal.pone.0075738. eCollection 2013.

Polyenylpyrrole derivatives inhibit NLRP3 inflammasome activation and inflammatory mediator expression by reducing reactive oxygen species production and mitogen-activated protein kinase activation.
Hua KF, Chou JC, Lam Y, Tasi YL, Chen A, Ka SM, Fang Z, Liu ML, Yang FL, Yang YL, Chiu YC, Wu SH.
PLoS One. 2013 Oct 7;8(10):e76754. doi: 10.1371/journal.pone.0076754. eCollection 2013.

The NOD2 receptor does not play a major role in the pathogenesis of Group B Streptococcus in mice.
Lemire P, Calzas C, Segura M.
Microb Pathog. 2013 Dec;65:41-7. doi: 10.1016/j.micpath.2013.09.006. Epub 2013 Oct 6.

NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production.
Gonçalves VM, Matteucci KC, Buzzo CL, Miollo BH, Ferrante D, Torrecilhas AC, Rodrigues MM, Alvarez JM, Bortoluci KR.
PLoS Negl Trop Dis. 2013 Oct 3;7(10):e2469. doi: 10.1371/journal.pntd.0002469. eCollection 2013.

A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice.
Zhu FG, Jiang W, Bhagat L, Wang D, Yu D, Tang JX, Kandimalla ER, La Monica N, Agrawal S.
Autoimmunity. 2013 Nov;46(7):419-28. doi: 10.3109/08916934.2013.798651. Epub 2013 Jun 12.

[Effect mechanism of NOD like receptor signaling pathway on intestinal mucosal barrier of rat during early phase of acute intra-abdominal infection].
Xiao YT, Li GX, Wang XM.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2013 Sep;25(9):527-32. doi: 10.3760/cma.j.issn.2095-4352.2013.09.005. Chinese. 

Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line.
Li S, Du L, Zhang L, Hu Y, Xia W, Wu J, Zhu J, Chen L, Zhu F, Li C, Yang S.
J Biol Chem. 2013 Oct 18;288(42):30094-104. doi: 10.1074/jbc.M113.494286. Epub 2013 Aug 28.

S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-κB(1.).
Simard JC, Cesaro A, Chapeton-Montes J, Tardif M, Antoine F, Girard D, Tessier PA.
PLoS One. 2013 Aug 19;8(8):e72138. doi: 10.1371/journal.pone.0072138. eCollection 2013.

Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation.
Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL, Sutterwala FS.
Immunity. 2013 Aug 22;39(2):311-323. doi: 10.1016/j.immuni.2013.08.001. Epub 2013 Aug 15.

Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells.
Hillegass JM, Miller JM, MacPherson MB, Westbom CM, Sayan M, Thompson JK, Macura SL, Perkins TN, Beuschel SL, Alexeeva V, Pass HI, Steele C, Mossman BT, Shukla
Part Fibre Toxicol. 2013 Aug 13;10:39. doi: 10.1186/1743-8977-10-39.

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3inflammasome in human macrophages.
Budai MM, Varga A, Milesz S, Tőzsér J, Benkő S.
Mol Immunol. 2013 Dec;56(4):471-9. doi: 10.1016/j.molimm.2013.05.005. Epub 2013 Aug 1.

Closing the loop on inflammation and atherothrombosis: why perform the CIRT and CANTOS trials?
Ridker PM.
Trans Am Clin Climatol Assoc. 2013;124:174-90.

A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome.
Anderson OA, Finkelstein A, Shima DT.
PLoS One. 2013 Jun 28;8(6):e67263. doi: 10.1371/journal.pone.0067263. Print 2013.

NLRP3 inflammasome knockout mice are protected against ischemic but not cisplatin-induced acute kidney injury.
Kim HJ, Lee DW, Ravichandran K, O Keys D, Akcay A, Nguyen Q, He Z, Jani A, Ljubanovic D, Edelstein CL.
J Pharmacol Exp Ther. 2013 Sep;346(3):465-72. doi: 10.1124/jpet.113.205732. Epub 2013 Jul 5.

Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-κB to the IL-1β promoter but is independent of nitric oxide.
Eigenbrod T, Bode KA, Dalpke AH.
J Immunol. 2013 Jun 15;190(12):6533-41. doi: 10.4049/jimmunol.1300324. Epub 2013 May 10.

NLRP3 deletion protects from hyperoxia-induced acute lung injury.
Fukumoto J, Fukumoto I, Parthasarathy PT, Cox R, Huynh B, Ramanathan GK, Venugopal RB, Allen-Gipson DS, Lockey RF, Kolliputi N.
Am J Physiol Cell Physiol. 2013 Jul 15;305(2):C182-9. doi: 10.1152/ajpcell.00086.2013. Epub 2013 May 1.

Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration.
Liu RT, Gao J, Cao S, Sandhu N, Cui JZ, Chou CL, Fang E, Matsubara JA.
Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2225-37. doi: 10.1167/iovs.12-10849.

Nalp3 inflammasome is activated and required for vascular smooth muscle cell calcification.
Wen C, Yang X, Yan Z, Zhao M, Yue X, Cheng X, Zheng Z, Guan K, Dou J, Xu T, Zhang Y, Song T, Wei C, Zhong H.
Int J Cardiol. 2013 Oct 3;168(3):2242-7. doi: 10.1016/j.ijcard.2013.01.211. Epub 2013 Feb 27.

An autoinflammatory neurological disease due to interleukin 6 hypersecretion.
Salsano E, Rizzo A, Bedini G, Bernard L, Dall’olio V, Volorio S, Lazzaroni M, Ceccherini I, Lazarevic D, Cittaro D, Stupka E, Paterra R, Farina L, Savoiardo M, Pareyson D, Sciacca FL.
J Neuroinflammation. 2013 Feb 21;10:29. doi: 10.1186/1742-2094-10-29.

Involvement of the NLRP3 inflammasome in the modulation of an LPS-induced inflammatory response during morphine tolerance.
Mao X, Sarkar S, Chang SL.
Drug Alcohol Depend. 2013 Sep 1;132(1-2):38-46. doi: 10.1016/j.drugalcdep.2012.12.022. Epub 2013 Jan 23.

Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome.
Pietrella D, Pandey N, Gabrielli E, Pericolini E, Perito S, Kasper L, Bistoni F, Cassone A, Hube B, Vecchiarelli A.
Eur J Immunol. 2013 Mar;43(3):679-92. doi: 10.1002/eji.201242691. Epub 2013 Jan 31.

Effects of small intestinal submucosa (SIS) on the murine innate immune microenvironment induced by heat-killed Staphylococcus aureus.
Roy Chowdhury R, Aachoui Y, Ghosh SK.
PLoS One. 2012;7(11):e48724. doi: 10.1371/journal.pone.0048724. Epub 2012 Nov 26.

Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse.
Toldo S, Mezzaroma E, Van Tassell BW, Farkas D, Marchetti C, Voelkel NF, Abbate A.
Exp Physiol. 2013 Mar;98(3):734-45. doi: 10.1113/expphysiol.2012.069831. Epub 2012 Nov 23.

Mice fed with a high fat diet show a decrease in the expression of “toll like receptor (TLR)2 and TLR6 mRNAs in adipose and hepatic tissues.
Betanzos-Cabrera G, Estrada-Luna D, Belefant-Miller H, Cancino-Díaz JC.
Nutr Hosp. 2012 Jul-Aug;27(4):1196-203. doi: 10.3305/nh.2012.27.4.5842.

NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury.
Savage CD, Lopez-Castejon G, Denes A, Brough D.
Front Immunol. 2012 Sep 18;3:288. eCollection 2012.

Differential activation of the inflammasome in THP-1 cells exposed to chrysotile asbestos and Libby “six-mix” amphiboles and subsequent activation of BEAS-2B cells.
Li M, Gunter ME, Fukagawa NK.
Cytokine. 2012 Dec;60(3):718-30. doi: 10.1016/j.cyto.2012.08.025. Epub 2012 Sep 25. Erratum in: Cytokine. 2017 Jun;94:59

Global effect of interleukin-10 on the transcriptional profile induced by Neisseria meningitidis in human monocytes.
Gopinathan U, Ovstebø R, Olstad OK, Brusletto B, Dalsbotten Aass HC, Kierulf P, Brandtzaeg P, Berg JP.
Infect Immun. 2012 Nov;80(11):4046-54. doi: 10.1128/IAI.00386-12. Epub 2012 Sep 10.

Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models.
McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD.
J Immunol. 2012 Sep 15;189(6):2707-11. doi: 10.4049/jimmunol.1101737. Epub 2012 Aug 17.

Deletion of the innate immune NLRP3 receptor abolishes cardiac ischemic preconditioning and is associated with decreased Il-6/STAT3 signaling.
Zuurbier CJ, Jong WM, Eerbeek O, Koeman A, Pulskens WP, Butter LM, Leemans JC, Hollmann MW.
PLoS One. 2012;7(7):e40643. doi: 10.1371/journal.pone.0040643. Epub 2012 Jul 27.

Novel role of PKR in inflammasome activation and HMGB1 release.
Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U,
Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ.
Nature. 2012 Aug 30;488(7413):670-4. doi: 10.1038/nature11290.

ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages.
Ayna G, Krysko DV, Kaczmarek A, Petrovski G, Vandenabeele P, Fésüs L.
PLoS One. 2012;7(6):e40069. doi: 10.1371/journal.pone.0040069. Epub 2012 Jun 29. 

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells–implications for age-related macular degeneration (AMD).
Kauppinen A, Niskanen H, Suuronen T, Kinnunen K, Salminen A, Kaarniranta K.
Immunol Lett. 2012 Sep;147(1-2):29-33. doi: 10.1016/j.imlet.2012.05.005. Epub 2012 Jun 12.

Activation of the inflammasome and enhanced migration of microparticle-stimulated dendritic cells to the draining lymph node.
Meraz IM, Melendez B, Gu J, Wong ST, Liu X, Andersson HA, Serda RE.
Mol Pharm. 2012 Jul 2;9(7):2049-62. doi: 10.1021/mp3001292. Epub 2012 Jun 8.

Ontogeny of Toll-like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infants.
Lisciandro JG, Prescott SL, Nadal-Sims MG, Devitt CJ, Pomat W, Siba PM, Tulic MC, Holt PG, Strickland D, van den Biggelaar AH.
PLoS One. 2012;7(5):e36793. doi: 10.1371/journal.pone.0036793. Epub 2012 May 23.

Antibody-mediated inhibition of integrin α5β1 blocks neurotoxic prion peptide PrP106-126-induced activation of BV2 microglia.
Chang J, Yang L, Kouadir M, Peng Y, Zhang S, Shi F, Zhou X, Yin X, Zhao D.
J Mol Neurosci. 2012 Sep;48(1):248-52. doi: 10.1007/s12031-012-9821-6. Epub 2012 May 31.

Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats.
Hu QH, Zhang X, Pan Y, Li YC, Kong LD.
Biochem Pharmacol. 2012 Jul 1;84(1):113-25. doi: 10.1016/j.bcp.2012.03.005. Epub 2012 Mar 16.

An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages.
Khare S, Dorfleutner A, Bryan NB, Yun C, Radian AD, de Almeida L, Rojanasakul Y, Stehlik C.
Immunity. 2012 Mar 23;36(3):464-76. doi: 10.1016/j.immuni.2012.02.001. Epub 2012 Feb 21.

Inflammasome-IL-1-Th17 response in allergic lung inflammation.
Besnard AG, Togbe D, Couillin I, Tan Z, Zheng SG, Erard F, Le Bert M, Quesniaux V, Ryffel B.
J Mol Cell Biol. 2012 Feb;4(1):3-10. doi: 10.1093/jmcb/mjr042. Epub 2011 Dec 6. Review.

NLRP3 E311K mutation in a large family with Muckle-Wells syndrome–description of a heterogeneous phenotype and response to treatment.
Kuemmerle-Deschner JB, Lohse P, Koetter I, Dannecker GE, Reess F, Ummenhofer K, Koch S, Tzaribachev N, Bialkowski A, Benseler SM.
Arthritis Res Ther. 2011;13(6):R196. doi: 10.1186/ar3526. Epub 2011 Dec 6.

Extracellular matrix from porcine small intestinal submucosa (SIS) as immune adjuvants.
Aachoui Y, Ghosh SK.
PLoS One. 2011;6(11):e27083. doi: 10.1371/journal.pone.0027083. Epub 2011 Nov 7.

Myxoma virus lacking the pyrin-like protein M013 is sensed in human myeloid cells by both NLRP3and multiple Toll-like receptors, which independently activate the inflammasome and NF-κB innate response pathways.
Rahman MM, McFadden G.
J Virol. 2011 Dec;85(23):12505-17. doi: 10.1128/JVI.00410-11. Epub 2011 Sep 28.

Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome.
Busillo JM, Azzam KM, Cidlowski JA.
J Biol Chem. 2011 Nov 4;286(44):38703-13. doi: 10.1074/jbc.M111.275370. Epub 2011 Sep 22.

The neuroprotective effect of a specific P2X₇ receptor antagonist derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells.
Murphy N, Cowley TR, Richardson JC, Virley D, Upton N, Walter D, Lynch MA.
Brain Pathol. 2012 May;22(3):295-306. doi: 10.1111/j.1750-3639.2011.00531.x. Epub 2011 Oct 27.

“Mutation negative” familial cold autoinflammatory syndrome (FCAS) in an 8-year-old boy: clinical course and functional studies.
Hedrich CM, Bruck N, Paul D, Hahn G, Gahr M, Rösen-Wolff A.
Rheumatol Int. 2012 Sep;32(9):2629-36. doi: 10.1007/s00296-011-2019-3. Epub 2011 Jul 22.

Molecular signatures of phytol-derived immunostimulants in the context of chemokine-cytokine microenvironment and enhanced immune response.
Aachoui Y, Chowdhury RR, Fitch RW, Ghosh SK.
Cell Immunol. 2011;271(2):227-38. doi: 10.1016/j.cellimm.2011.07.001. Epub 2011 Jul 14.

Role of IL-1 beta in the development of human T(H)17 cells: lesson from NLPR3 mutated patients.
Lasigliè D, Traggiai E, Federici S, Alessio M, Buoncompagni A, Accogli A, Chiesa S, Penco F, Martini A, Gattorno M.
PLoS One. 2011;6(5):e20014. doi: 10.1371/journal.pone.0020014. Epub 2011 May 26.

Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice.
Ather JL, Ckless K, Martin R, Foley KL, Suratt BT, Boyson JE, Fitzgerald KA, Flavell RA, Eisenbarth SC, Poynter ME.
J Immunol. 2011 Jul 1;187(1):64-73. doi: 10.4049/jimmunol.1100500. Epub 2011 May 27.

Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout.
Martin WJ, Shaw O, Liu X, Steiger S, Harper JL.
Arthritis Rheum. 2011 May;63(5):1322-32. doi: 10.1002/art.30249.

Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome.
Sauter KA, Wood LJ, Wong J, Iordanov M, Magun BE.
Cancer Biol Ther. 2011 Jun 15;11(12):1008-16. Epub 2011 Jun 15.

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS).
Bulua AC, Simon A, Maddipati R, Pelletier M, Park H, Kim KY, Sack MN, Kastner DL, Siegel RM.
J Exp Med. 2011 Mar 14;208(3):519-33. doi: 10.1084/jem.20102049. Epub 2011 Jan 31.

Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice.
Zhu P, Duan L, Chen J, Xiong A, Xu Q, Zhang H, Zheng F, Tan Z, Gong F, Fang M.
Hum Gene Ther. 2011 Jul;22(7):853-64. doi: 10.1089/hum.2010.145. Epub 2011 Mar 7.

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V,
Andrew PW, Kadioglu A, Lavelle EC.
PLoS Pathog. 2010 Nov 11;6(11):e1001191. doi: 10.1371/journal.ppat.1001191.

Synergism of NOD2 and NLRP3 activators promotes a unique transcriptional profile in murine dendritic cells.
Conforti-Andreoni C, Beretta O, Licandro G, Qian HL, Urbano M, Vitulli F, Ricciardi-Castagnoli P, Mortellaro A.
J Leukoc Biol. 2010 Dec;88(6):1207-16. doi: 10.1189/jlb.1009652. Epub 2010 Sep 30.

Standardized tape stripping prior to patch testing induces upregulation of Hsp90, Hsp70, IL-33, TNF-α and IL-8/CXCL8 mRNA: new insights into the involvement of ‘alarmins’.
Dickel H, Gambichler T, Kamphowe J, Altmeyer P, Skrygan M.
Contact Dermatitis. 2010 Oct;63(4):215-22. doi: 10.1111/j.1600-0536.2010.01769.x. Epub 2010 Aug 20.

Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors.
Qiu F, Maniar A, Diaz MQ, Chapoval AI, Medvedev AE.
Innate Immun. 2011 Aug;17(4):375-87. doi: 10.1177/1753425910372000. Epub 2010 Aug 3.

Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia.
Xie F, Hu Y, Turvey SE, Magee LA, Brunham RM, Choi KC, Krajden M, Leung PC, Money DM, Patrick DM, Thomas E, von Dadelszen P.
BJOG. 2010 Jan;117(1):99-108. doi: 10.1111/j.1471-0528.2009.02428.x.

Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid.
Griffith JW, Sun T, McIntosh MT, Bucala R.
J Immunol. 2009 Oct 15;183(8):5208-20. doi: 10.4049/jimmunol.0713552. Epub 2009 Sep 25.

The RD1 locus in the Mycobacterium tuberculosis genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages.
Kurenuma T, Kawamura I, Hara H, Uchiyama R, Daim S, Dewamitta SR, Sakai S, Tsuchiya K, Nomura T, Mitsuyama M.
Infect Immun. 2009 Sep;77(9):3992-4001. doi: 10.1128/IAI.00015-09. Epub 2009 Jul 13.

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J.
Nature. 2009 Jul 9;460(7252):269-73. doi: 10.1038/nature08100. Epub 2009 Jun 3.

Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria.
Nakamura Y, Kambe N, Saito M, Nishikomori R, Kim YG, Murakami M, Núñez G, Matsue H.
J Exp Med. 2009 May 11;206(5):1037-46. doi: 10.1084/jem.20082179. Epub 2009 Apr 13. Erratum in:
J Exp Med. 2009 May 11;206(5):1205. Nishikomiri, Ryuta [corrected to Nishikomori, Ryuta]. 

In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes.
Lachmann HJ, Lowe P, Felix SD, Rordorf C, Leslie K, Madhoo S, Wittkowski H, Bek S, Hartmann N, Bosset S, Hawkins PN, Jung T.
J Exp Med. 2009 May 11;206(5):1029-36. doi: 10.1084/jem.20082481. Epub 2009 Apr 13.

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome.
Sharp FA, Ruane D, Claass B, Creagh E, Harris J, Malyala P, Singh M, O’Hagan DT, Pétrilli V, Tschopp J, O’Neill LA, Lavelle EC.
Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):870-5. doi: 10.1073/pnas.0804897106. Epub 2009 Jan 12.

The NALP3/Cryopyrin-inflammasome complex is expressed in LPS-induced ocular inflammation.
González-Benítez JF, Juárez-Verdayes MA, Rodríguez-Martínez S, Cancino-Diaz ME, García-Vázquez F, Cancino-Diaz JC.
Mediators Inflamm. 2008;2008:614345. doi: 10.1155/2008/614345.

A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndrome.
Goldbach-Mansky R, Shroff SD, Wilson M, Snyder C, Plehn S, Barham B, Pham TH, Pucino F, Wesley RA, Papadopoulos JH, Weinstein SP, Mellis SJ, Kastner DL.
Arthritis Rheum. 2008 Aug;58(8):2432-42. doi: 10.1002/art.23620.

The Nalp3 inflammasome is essential for the development of silicosis.
Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS.
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9035-40. doi: 10.1073/pnas.0803933105. Epub 2008 Jun 24.

Downregulation of immune signaling genes in patients with large surface burn injury.
Moore CB, Medina MA, van Deventer HW, O’Connor BP, Cameron S, Taxman DJ, Maile R, Ting JP, Cairns BA.
J Burn Care Res. 2007 Nov-Dec;28(6):879-87.

MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.
Pan Q, Mathison J, Fearns C, Kravchenko VV, Da Silva Correia J, Hoffman HM, Kobayashi KS, Bertin J, Grant EP, Coyle AJ, Sutterwala FS, Ogura Y, Flavell RA, Ulevitch RJ.
J Leukoc Biol. 2007 Jul;82(1):177-83. Epub 2007 Apr 2.

Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia.
Rosengren S, Mueller JL, Anderson JP, Niehaus BL, Misaghi A, Anderson S, Boyle DL, Hoffman HM.
J Allergy Clin Immunol. 2007 Apr;119(4):991-6. Epub 2007 Feb 22.

A severe case of chronic infantile neurologic, cutaneous, articular syndrome treated with biologic agents.
Matsubara T, Hasegawa M, Shiraishi M, Hoffman HM, Ichiyama T, Tanaka T, Ueda H, Ishihara T, Furukawa S.
Arthritis Rheum. 2006 Jul;54(7):2314-20.

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.
Kanneganti TD, Ozören N, Body-Malapel M, Amer A, Park JH, Franchi L, Whitfield J, Barchet W, Colonna M, Vandenabeele P, Bertin J, Coyle A, Grant EP, Akira S, Núñez G.
Nature. 2006 Mar 9;440(7081):233-6. Epub 2006 Jan 11.

Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist.
Hoffman HM, Rosengren S, Boyle DL, Cho JY, Nayar J, Mueller JL, Anderson JP, Wanderer AA, Firestein GS.
Lancet. 2004 Nov 13-19;364(9447):1779-85.

A novel CIAS1 mutation and plasma/cerebrospinal fluid cytokine profile in a German patient with neonatal-onset multisystem inflammatory disease responsive to methotrexate therapy.
Stojanov S, Weiss M, Lohse P, Belohradsky BH.
Pediatrics. 2004 Jul;114(1):e124-7.

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.
Aksentijevich I, Nowak M, Mallah M, Chae JJ, Watford WT, Hofmann SR, Stein L, Russo R, Goldsmith D, Dent P, Rosenberg HF, Austin F, Remmers EF, Balow JE Jr, Rosenzweig S, Komarow H, Shoham NG, Wood G, Jones J, Mangra N, Carrero H, Adams BS, Moore TL, Schikler K, Hoffman H, Lovell DJ, Lipnick R, Barron K, O’Shea JJ, Kastner DL, Goldbach-Mansky R.
Arthritis Rheum. 2002 Dec;46(12):3340-8.