Azithromycin and NLRP3

New insights in neutrophilic asthma.
Seys SF, Lokwani R, Simpson JL, Bullens DMA.
Curr Opin Pulm Med. 2019 Jan;25(1):113-120. doi: 10.1097/MCP.0000000000000543. Review.

Macrolides protect against Pseudomonas aeruginosa infection via inhibition of inflammasomes.
Fan LC, Lin JL, Yang JW, Mao B, Lu HW, Ge BX, Choi AMK, Xu JF.
Am J Physiol Lung Cell Mol Physiol. 2017 Oct 1;313(4):L677-L686. doi: 10.1152/ajplung.00123.2017. Epub 2017 Jul 6.

Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation.
Lendermon EA, Coon TA, Bednash JS, Weathington NM, McDyer JF, Mallampalli RK.
Respir Res. 2017 Jun 28;18(1):131. doi: 10.1186/s12931-017-0608-8.

Nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases.
Hodge S, Tran HB, Hamon R, Roscioli E, Hodge G, Jersmann H, Ween M, Reynolds PN, Yeung A, Treiberg J, Wilbert S.
Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L678-L687. doi: 10.1152/ajplung.00518.2016. Epub 2017 Mar 3.