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Chloroquine and NLRP3

Lysosomotropic drugs enhance pro-inflammatory responses to IL-1β in macrophages by inhibiting internalization of the IL-1 receptor.
Lübow C, Bockstiegel J, Weindl G.
Biochem Pharmacol. 2020 Feb 20;175:113864. doi: 10.1016/j.bcp.2020.113864. [Epub ahead of print]

Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Wang R, Zhu Y, Ren C, Yang S, Tian S, Chen H, Jin M, Zhou H.
Autophagy. 2020 Feb 11:1-16. doi: 10.1080/15548627.2020.1725375. [Epub ahead of print]

URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion.
Su SH, Wu YF, Lin Q, Wang DP, Hai J.
J Neuroinflammation. 2019 Dec 9;16(1):260. doi: 10.1186/s12974-019-1668-0.

Prevention of crystalline silica-induced inflammation by the anti-malarial hydroxychloroquine.
Burmeister R, Rhoderick JF, Holian A.
Inhal Toxicol. 2019 Jun;31(7):274-284. doi: 10.1080/08958378.2019.1668091. Epub 2019 Sep 26.

Mitophagy protects against acetaminophen-induced acute liver injury in mice through inhibiting NLRP3inflammasome activation.
Shan S, Shen Z, Zhang C, Kou R, Xie K, Song F.
Biochem Pharmacol. 2019 Nov;169:113643. doi: 10.1016/j.bcp.2019.113643. Epub 2019 Sep 19.

Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice.
Geng J, Liu J, Yuan X, Liu W, Guo W.
Toxicol Appl Pharmacol. 2019 Sep 15;379:114688. doi: 10.1016/j.taap.2019.114688. Epub 2019 Jul 21.

Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1β Expression in Primary Mouse Cardiac Fibroblasts.
Torp MK, Yang K, Ranheim T, Husø Lauritzen K, Alfsnes K, Vinge LE, Aukrust P, Stensløkken KO, Yndestad A, Sandanger Ø.
Front Immunol. 2019 Jun 6;10:1285. doi: 10.3389/fimmu.2019.01285. eCollection 2019.

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.
Han X, Sun S, Sun Y, Song Q, Zhu J, Song N, Chen M, Sun T, Xia M, Ding J, Lu M, Yao H, Hu G.
Autophagy. 2019 Nov;15(11):1860-1881. doi: 10.1080/15548627.2019.1596481. Epub 2019 Apr 9.

[Trimetazidine reduces cholesterol content of foam cells by up-regulating autophagy and macrophage extracellular traps, and inhibiting inflammasome].
Li Y, Hou W, Li T, Zhao J.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018 Nov;34(11):969-976. Chinese. 

Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries.
Yuan X, Bhat OM, Meng N, Lohner H, Li PL.
Am J Pathol. 2018 Dec;188(12):2948-2959. doi: 10.1016/j.ajpath.2018.08.014. Epub 2018 Sep 29.

Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation.
Tang TT, Lv LL, Pan MM, Wen Y, Wang B, Li ZL, Wu M, Wang FM, Crowley SD, Liu BC.
Cell Death Dis. 2018 Mar 2;9(3):351. doi: 10.1038/s41419-018-0378-3.

Pro-inflammatory Ca++-activated K+ channels are inhibited by hydroxychloroquine.
Eugenia Schroeder M, Russo S, Costa C, Hori J, Tiscornia I, Bollati-Fogolín M, Zamboni DS, Ferreira G, Cairoli E, Hill M.
Sci Rep. 2017 May 15;7(1):1892. doi: 10.1038/s41598-017-01836-8.

The Antimalarial Chloroquine Suppresses LPS-Induced NLRP3 Inflammasome Activation and Confers Protection against Murine Endotoxic Shock.
Chen X, Wang N, Zhu Y, Lu Y, Liu X, Zheng J.
Mediators Inflamm. 2017;2017:6543237. doi: 10.1155/2017/6543237. Epub 2017 Feb 22.

Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent.
Mishra AR, Zheng J, Tang X, Goering PL.
Toxicol Sci. 2016 Apr;150(2):473-87. doi: 10.1093/toxsci/kfw011. Epub 2016 Jan 21.

Anti-inflammatory therapies for cardiovascular disease.
Ridker PM, Lüscher TF.
Eur Heart J. 2014 Jul 14;35(27):1782-91. doi: 10.1093/eurheartj/ehu203. Epub 2014 May 26. Review.

Sodium overload and water influx activate the NALP3 inflammasome.
Schorn C, Frey B, Lauber K, Janko C, Strysio M, Keppeler H, Gaipl US, Voll RE, Springer E, Munoz LE, Schett G, Herrmann M.
J Biol Chem. 2011 Jan 7;286(1):35-41. doi: 10.1074/jbc.M110.139048. Epub 2010 Nov 4.

SNP-guided microRNA maps (MirMaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways.
Glinsky GV.
Cell Cycle. 2008 Nov 15;7(22):3564-76. Epub 2008 Nov 26.