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Cardiovascular Disease and NLRP3


Microglia-Derived NLRP3 Activation Mediates the Pressor Effect of Prorenin in the Rostral Ventrolateral Medulla of Stress-Induced Hypertensive Rats.
Hu L, Zhang S, Ooi K, Wu X, Wu J, Cai J, Sun Y, Wang J, Zhu D, Chen F, Xia C.
Neurosci Bull. 2020 Apr 3. doi: 10.1007/s12264-020-00484-9. [Epub ahead of print]

The Role of NLRP3 Inflammasome in Radiation-Induced Cardiovascular Injury.
Huang S, Che J, Chu Q, Zhang P.
Front Cell Dev Biol. 2020 Mar 12;8:140. doi: 10.3389/fcell.2020.00140. eCollection 2020. Review

Targeting the NLRP3 Inflammasome With Inhibitor MCC950 Prevents Aortic Aneurysms and Dissections in Mice.
Ren P, Wu D, Appel R, Zhang L, Zhang C, Luo W, Robertson AAB, Cooper MA, Coselli JS, Milewicz DM, Shen YH, LeMaire SA.
J Am Heart Assoc. 2020 Apr 7;9(7):e014044. doi: 10.1161/JAHA.119.014044. Epub 2020 Mar 30.

Impact of curcumin supplementation on expression of inflammatory transcription factors in hemodialysis patients: A pilot randomized, double-blind, controlled study.
Alvarenga L, Salarolli R, Cardozo LFMF, Santos RS, de Brito JS, Kemp JA, Reis D, de Paiva BR, Stenvinkel P, Lindholm B, Fouque D, Mafra D.
Clin Nutr. 2020 Mar 13. pii: S0261-5614(20)30110-2. doi: 10.1016/j.clnu.2020.03.007. [Epub ahead of print]

Sex differences in inflammation, redox biology, mitochondria and autoimmunity.
Di Florio DN, Sin J, Coronado MJ, Atwal PS, Fairweather D.
Redox Biol. 2020 Mar 4:101482. doi: 10.1016/j.redox.2020.101482. [Epub ahead of print] Review.

Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis.
Mai W, Xu Y, Xu J, Zhao D, Ye L, Yu G, Wang Z, Lu Q, Lin J, Yang T, Gu C, Liu S, Zhong Y, Yang H.
Front Pharmacol. 2020 Mar 3;11:185. doi: 10.3389/fphar.2020.00185. eCollection 2020.

Ox-LDL Causes Endothelial Cell Injury Through ASK1/NLRP3-Mediated Inflammasome Activation via Endoplasmic Reticulum Stress.
Hang L, Peng Y, Xiang R, Li X, Li Z.
Drug Des Devel Ther. 2020 Feb 24;14:731-744. doi: 10.2147/DDDT.S231916. eCollection 2020

Understanding Inflammatory Responses in the Manifestation of Prothrombotic Phenotypes.
Chanchal S, Mishra A, Singh MK, Ashraf MZ.
Front Cell Dev Biol. 2020 Feb 14;8:73. doi: 10.3389/fcell.2020.00073. eCollection 2020. Review.

Hydrogen Sulfide Attenuates Particulate Matter-Induced Emphysema and Airway Inflammation Through Nrf2-Dependent Manner.
Jia G, Yu S, Sun W, Yang J, Wang Y, Qi Y, Chen Y.
Front Pharmacol. 2020 Feb 7;11:29. doi: 10.3389/fphar.2020.00029. eCollection 2020.

A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress.
Zhang YF, Sun CC, Duan JX, Yang HH, Zhang CY, Xiong JB, Zhong WJ, Zu C, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX.
Biomed Pharmacother. 2020 Feb 27;126:109907. doi: 10.1016/j.biopha.2020.109907. [Epub ahead of print]

Ticagrelor Increases SIRT1 and HES1 mRNA Levels in Peripheral Blood Cells from Patients with Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease.
Aquila G, Vieceli Dalla Sega F, Marracino L, Pavasini R, Cardelli LS, Piredda A, Scoccia A, Martino V, Fortini F, Bononi I, Martini F, Manfrini M, Pannuti A, Ferrari R, Rizzo P Campo G.
Int J Mol Sci. 2020 Feb 25;21(5). pii: E1576. doi: 10.3390/ijms21051576.

Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis.
Pinar AA, Scott TE, Huuskes BM, Tapia Cáceres FE, Kemp-Harper BK, Samuel CS.
Pharmacol Ther. 2020 Feb 22:107511. doi: 10.1016/j.pharmthera.2020.107511. [Epub ahead of print] Review.

Electroacupuncture preconditioning attenuates acute myocardial ischemia injury through inhibiting NLRP3 inflammasome activation in mice.
Zhang T, Yang WX, Wang YL, Yuan J, Qian Y, Sun QM, Yu ML, Fu SP, Xu B, Lu SF.
Life Sci. 2020 May 1;248:117451. doi: 10.1016/j.lfs.2020.117451. Epub 2020 Feb 20.

M2 macrophage-derived exosomes carry microRNA-148a to alleviate myocardial ischemia/reperfusion injury via inhibiting TXNIP and the TLR4/NF-κB/NLRP3 inflammasome signaling pathway.
Dai Y, Wang S, Chang S, Ren D, Shali S, Li C, Yang H, Huang Z, Ge J.
J Mol Cell Cardiol. 2020 Feb 19. pii: S0022-2828(20)30044-4. doi: 10.1016/j.yjmcc.2020.02.007. [Epub ahead of print]

Emerging therapeutic targets for NASH: key innovations at the preclinical level.
Horn P, Newsome PN.
Expert Opin Ther Targets. 2020 Mar;24(3):175-186. doi: 10.1080/14728222.2020.1728742. Epub 2020 Feb 13.

Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Yao RQ, Ren C, Xia ZF, Yao YM.
Autophagy. 2020 Feb 12:1-17. doi: 10.1080/15548627.2020.1725377. [Epub ahead of print 

Role of NLRP3-Inflammasome/Caspase-1/Galectin-3 Pathway on Atrial Remodeling in Diabetic Rabbits.
Wu X, Liu Y, Tu D, Liu X, Niu S, Suo Y, Liu T, Li G, Liu C.
J Cardiovasc Transl Res. 2020 Feb 11. doi: 10.1007/s12265-020-09965-8. [Epub ahead of print]

Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3inflammasome activation.
Sun ZM, Guan P, Luo LF, Qin LY, Wang N, Zhao YS, Ji ES.
Life Sci. 2020 Mar 15;245:117362. doi: 10.1016/j.lfs.2020.117362. Epub 2020 Jan 27.

13-Methylberberine improves endothelial dysfunction by inhibiting NLRP3 inflammasome activation via autophagy induction in human umbilical vein endothelial cells
Peng Z, Zhan H, Shao Y, Xiong Y, Zeng L, Zhang C, Liu Z, Huang Z, Su H, Yang Z.
Chin Med. 2020 Jan 22;15:8. doi: 10.1186/s13020-020-0286-1. eCollection 2020.

Inhibition of Dectin-1 in mice ameliorates cardiac remodeling by suppressing NF-κB/NLRP3 signaling after myocardial infarction.
Li X, Bian Y, Pang P, Yu S, Wang X, Gao Y, Liu K, Liu Q, Yuan Y, Du W.
Int Immunopharmacol. 2020 Mar;80:106116. doi: 10.1016/j.intimp.2019.106116. Epub 2020 Jan 21.

VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis.
Li Y, Niu X, Xu H, Li Q, Meng L, He M, Zhang J, Zhang Z, Zhang Z.
Exp Cell Res. 2020 Apr 1;389(1):111847. doi: 10.1016/j.yexcr.2020.111847. Epub 2020 Jan 20.

Neutrophil Extracellular Traps and Cardiovascular Diseases: An Update.
Bonaventura A, Vecchié A, Abbate A, Montecucco F.
Cells. 2020 Jan 17;9(1). pii: E231. doi: 10.3390/cells9010231. Review.

α-Bisabolol protects against β-adrenergic agonist-induced myocardial infarction in rats by attenuating inflammation, lysosomal dysfunction, NLRP3 inflammasome activation and modulating autophagic flux.
Nagoor Meeran MF, Azimullah S, Laham F, Tariq S, Goyal SN, Adeghate E, Ojha S.
Food Funct. 2020 Jan 29;11(1):965-976. doi: 10.1039/c9fo00530g.

Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals.
Zhang X, Li Y, Yang P, Liu X, Lu L, Chen Y, Zhong X, Li Z, Liu H, Ou C, Yan J, Chen M.
Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):751-765. doi: 10.1161/ATVBAHA.119.313414. Epub 2020 Jan 16.

Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction.
Sreejit G, Abdel-Latif A, Athmanathan B, Annabathula R, Dhyani A, Noothi SK, Quaife-Ryan GA, Al-Sharea A, Pernes G, Dragoljevic D, Lal H, Schroder K, Hanaoka BY, Raman C, Grant MB, Hudson JE, Smyth SS, Porrello ER, Murphy AJ, Nagareddy PR.
Circulation. 2020 Mar 31;141(13):1080-1094. doi: 10.1161/CIRCULATIONAHA.119.043833. Epub 2020 Jan 16.

The antagonism of 6-shogaol in high-glucose-activated NLRP3 inflammasome and consequent calcification of human artery smooth muscle cells.
Chen TC, Yen CK, Lu YC, Shi CS, Hsieh RZ, Chang SF, Chen CN.
Cell Biosci. 2020 Jan 9;10:5. doi: 10.1186/s13578-019-0372-1. eCollection 2020.

[Mechanism of microglia promoting retinal ganglion cell death in vitro].
Li F, Jiang N, Zhu YT, Su WR, Zhuo YH.
Zhonghua Yan Ke Za Zhi. 2020 Jan 11;56(1):32-40. doi: 10.3760/cma.j.issn.0412-4081.2020.01.010. Chinese. 

miR‑20b inhibits the senescence of human umbilical vein endothelial cells through regulating the Wnt/β‑catenin pathway via the TXNIP/NLRP3 axis.
Dong F, Dong S, Liang Y, Wang K, Qin Y, Zhao X.
Int J Mol Med. 2020 Mar;45(3):847-857. doi: 10.3892/ijmm.2020.4457. Epub 2020 Jan 8.

Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart.
Fender AC, Kleeschulte S, Stolte S, Leineweber K, Kamler M, Bode J, Li N, Dobrev D.
Basic Res Cardiol. 2020 Jan 7;115(2):10. doi: 10.1007/s00395-019-0771-9.

Transplantation of Lymphocytes Co-Cultured with Human Cord Blood-Derived Multipotent Stem Cells Attenuates Inflammasome Activity in Ischemic Stroke.
Zhao Y, Zhu T, Li H, Zhao J, Li X.
Clin Interv Aging. 2019 Dec 19;14:2261-2271. doi: 10.2147/CIA.S223595. eCollection 2019.

SNO-MLP (S-Nitrosylation of Muscle LIM Protein) Facilitates Myocardial Hypertrophy Through TLR3 (Toll-Like Receptor 3)-Mediated RIP3 (Receptor-Interacting Protein Kinase 3) and NLRP3 (NOD-Like Receptor Pyrin Domain Containing 3) Inflammasome Activation.
Tang X, Pan L, Zhao S, Dai F, Chao M, Jiang H, Li X, Lin Z, Huang Z, Meng G, Wang C, Chen C, Liu J, Wang X, Ferro A, Wang H, Chen H, Gao Y, Lu Q, Xie L, Han Y, Ji Y.
Circulation. 2020 Mar 24;141(12):984-1000. doi: 10.1161/CIRCULATIONAHA.119.042336. Epub 2020 Jan 6.

Response to letter on “Relaxin inhibits macrophage inflammation by repressing NLRP3” by Zhou et al.
Beiert T, Knappe V, Andrié RP, Schrickel JW.
Int J Cardiol. 2020 Jan 1;298:118. doi: 10.1016/j.ijcard.2019.09.047. No abstract available. 

Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway.
Wei H, Bu R, Yang Q, Jia J, Li T, Wang Q, Chen Y.
J Diabetes Res. 2019 Dec 9;2019:8905917. doi: 10.1155/2019/8905917. eCollection 2019.

ALDH2 Overexpression Alleviates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3Inflammasome Activation.
Cao R, Fang D, Wang J, Yu Y, Ye H, Kang P, Li Z, Wang H, Gao Q.
J Diabetes Res. 2019 Nov 21;2019:4857921. doi: 10.1155/2019/4857921. eCollection 2019.

MiR-135b protects cardiomyocytes from infarction through restraining the NLRP3/caspase-1/IL-1β pathway.
Li A, Yu Y, Ding X, Qin Y, Jiang Y, Wang X, Liu G, Chen X, Yue E, Sun X, Zahra SM, Yan Y, Ren L, Wang S, Chai L, Bai Y, Yang B.
Int J Cardiol. 2019 Nov 17. pii: S0167-5273(19)32176-X. doi: 10.1016/j.ijcard.2019.09.055. [Epub ahead of print]

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3signaling pathway.
Bai Y, Li Z, Liu W, Gao D, Liu M, Zhang P.
Acta Cir Bras. 2019 Dec 20;34(11):e201901104. doi: 10.1590/s0102-865020190110000004. eCollection 2019.

Beyond urate lowering: Analgesic and anti-inflammatory properties of allopurinol.
Schlesinger N, Brunetti L.
Semin Arthritis Rheum. 2019 Nov 15. pii: S0049-0172(19)30690-0. doi: 10.1016/j.semarthrit.2019.11.009. [Epub ahead of print] Review.

Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease.
Anzai F, Watanabe S, Kimura H, Kamata R, Karasawa T, Komada T, Nakamura J, Nagi-Miura N, Ohno N, Takeishi Y, Takahashi M.
J Mol Cell Cardiol. 2020 Jan;138:185-196. doi: 10.1016/j.yjmcc.2019.11.158. Epub 2019 Dec 10.

Inflammasome in HIV infection: Lights and shadows.
Leal VNC, Reis EC, Pontillo A.
Mol Immunol. 2020 Feb;118:9-18. doi: 10.1016/j.molimm.2019.12.001. Epub 2019 Dec 10. Review.

Eicosapentaenoic acid prevents inflammation induced by acute cerebral infarction through inhibition of NLRP3 inflammasome activation.
Mo Z, Tang C, Li H, Lei J, Zhu L, Kou L, Li H, Luo S, Li C, Chen W, Zhang L.
Life Sci. 2020 Feb 1;242:117133. doi: 10.1016/j.lfs.2019.117133. Epub 2019 Dec 9.

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation.
Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Schuster S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T.
Nat Immunol. 2020 Jan;21(1):30-41. doi: 10.1038/s41590-019-0548-1. Epub 2019 Dec 9.

Dietary Apigenin Reduces Induction of LOX-1 and NLRP3 Expression, Leukocyte Adhesion, and Acetylated Low-Density Lipoprotein Uptake in Human Endothelial Cells Exposed to Trimethylamine-N-Oxide.
Yamagata K, Hashiguchi K, Yamamoto H, Tagami M.
J Cardiovasc Pharmacol. 2019 Dec;74(6):558-565. doi: 10.1097/FJC.0000000000000747.

Relaxin inhibits macrophage inflammation by repressing NLRP3.
Zhou HF, Ren K, Zhao GJ.
Int J Cardiol. 2020 Jan 15;299:254. doi: 10.1016/j.ijcard.2019.09.018. No abstract available. 

Curcumin Management of Myocardial Fibrosis and its Mechanisms of Action: A Review.
Yu Y, Sun J, Wang R, Liu J, Wang P, Wang C.
Am J Chin Med. 2019;47(8):1675-1710. doi: 10.1142/S0192415X19500861. Epub 2019 Dec 2.

ROS-induced NLRP3 inflammasome priming and activation mediate PCB 118- induced pyroptosis in endothelial cells.
Long Y, Liu X, Tan XZ, Jiang CX, Chen SW, Liang GN, He XM, Wu J, Chen T, Xu Y.
Ecotoxicol Environ Saf. 2020 Feb;189:109937. doi: 10.1016/j.ecoenv.2019.109937. Epub 2019 Nov 27.

Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice.
Wang Q, Ou Y, Hu G, Wen C, Yue S, Chen C, Xu L, Xie J, Dai H, Xiao H, Zhang Y, Qi R.
Br J Pharmacol. 2020 Apr;177(8):1806-1821. doi: 10.1111/bph.14938. Epub 2020 Jan 30.

Pharmacological Inhibitors of the NLRP3 Inflammasome.
Zahid A, Li B, Kombe AJK, Jin T, Tao J.
Front Immunol. 2019 Oct 25;10:2538. doi: 10.3389/fimu.2019.02538. eCollection 2019. Review.

AdipoRon Alleviates Free Fatty Acid-Induced Myocardial Cell Injury Via Suppressing Nlrp3Inflammasome Activation.
Zhang YZ, Zhang YL, Huang Q, Huang C, Jiang ZL, Cai F, Shen JF.
Diabetes Metab Syndr Obes. 2019 Oct 23;12:2165-2179. doi: 10.2147/DMSO.S221841. eCollection 2019.

Qingkailing injection ameliorates cerebral ischemia-reperfusion injury and modulates the AMPK/NLRP3 Inflammasome Signalling pathway.
Ma C, Wang X, Xu T, Yu X, Zhang S, Liu S, Gao Y, Fan S, Li C, Zhai C, Cheng F, Wang Q.
BMC Complement Altern Med. 2019 Nov 20;19(1):320. doi: 10.1186/s12906-019-2703-5.

Nano-Antagonist Alleviates Inflammation and Allows for MRI of Atherosclerosis.
Mog B, Asase C, Chaplin A, Gao H, Rajagopalan S, Maiseyeu A.
Nanotheranostics. 2019 Nov 1;3(4):342-355. doi: 10.7150/ntno.37391. eCollection 2019.

Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism.
Li H, Qian F, Liu H, Zhang Z.
Med Sci Monit. 2019 Nov 10;25:8457-8464. doi: 10.12659/MSM.916667.

Edaravone Administration Confers Neuroprotection after Experimental Intracerebral Hemorrhage in Rats via NLRP3 Suppression.
Miao H, Jiang Y, Geng J, Zhang B, Zhu G, Tang J.
J Stroke Cerebrovasc Dis. 2020 Jan;29(1):104468. doi: 10.1016/j.jstrokecerebrovasdis.2019.104468. Epub 2019 Nov 4.

The active components derived from Penthorum chinensePursh protect against oxidative-stress-induced vascular injury via autophagy induction.
Sun X, Wu A, Kwan Law BY, Liu C, Zeng W, Ling Qiu AC, Han Y, He Y, Wai Wong VK.
Free Radic Biol Med. 2020 Jan;146:160-180. doi: 10.1016/j.freeradbiomed.2019.10.417. Epub 2019 Nov 2.

Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis.
Kang P, Wang J, Fang D, Fang T, Yu Y, Zhang W, Shen L, Li Z, Wang H, Ye H, Gao Q.
Free Radic Biol Med. 2020 Jan;146:198-210. doi: 10.1016/j.freeradbiomed.2019.10.416. Epub 2019 Nov 2.

Serelaxin inhibits the profibrotic TGF-β1/IL-1β axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts.
Cáceres FT, Gaspari TA, Samuel CS, Pinar AA.
FASEB J. 2019 Dec;33(12):14717-14733. doi: 10.1096/fj.201901079RR. Epub 2019 Nov 5.

ER Stress Activates the NLRP3 Inflammasome: A Novel Mechanism of Atherosclerosis.
Chen X, Guo X, Ge Q, Zhao Y, Mu H, Zhang J.
Oxid Med Cell Longev. 2019 Oct 7;2019:3462530. doi: 10.1155/2019/3462530. eCollection 2019. Review.

Aerobic Exercise Ameliorates Myocardial Inflammation, Fibrosis and Apoptosis in High-Fat-Diet Rats by Inhibiting P2X7 Purinergic Receptors.
Chen X, Li H, Wang K, Liang X, Wang W, Hu X, Huang Z, Wang Y.
Front Physiol. 2019 Oct 11;10:1286. doi: 10.3389/fphys.2019.01286. eCollection 2019.

Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.
Peng F, Zhang N, Wang C, Wang X, Huang W, Peng C, He G, Han B.
Cell Prolif. 2020 Jan;53(1):e12701. doi: 10.1111/cpr.12701. Epub 2019 Oct 27

Ethanol and its metabolites: update on toxicity, benefits, and focus on immunomodulatory effects.
Le Daré B, Lagente V, Gicquel T.
Drug Metab Rev. 2019 Nov;51(4):545-561. doi: 10.1080/03602532.2019.1679169. Epub 2019 Oct 24. Review.

Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis.
Bian Y, Li X, Pang P, Hu XL, Yu ST, Liu YN, Li X, Wang N, Wang JH, Xiao W, Du WJ, Yang BF.
Acta Pharmacol Sin. 2020 Mar;41(3):319-326. doi: 10.1038/s41401-019-0307-8. Epub 2019 Oct 23.

[Expression of Nod-like receptor protein 3 inflammasome in peripheral blood mononuclear cells of children with Kawasaki disease in the acute stage].
Liu LP, Yuan YH, He XH, Chen M, Peng DX, Xu W, Xia XH, Cao YD, Wang S, Zhu QL.
Zhongguo Dang Dai Er Ke Za Zhi. 2019 Oct;21(10):992-997. Chinese. 

NLRP3 is associated with coronary artery disease in Vietnam veterans.
Akosile W, Voisey J, Lawford B, Colquhoun D, McD Young R, Mehta D; PTSD Initiative.
Gene. 2020 Jan 30;725:144163. doi: 10.1016/j.gene.2019.144163. Epub 2019 Oct 19.

NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.
Marín-Aguilar F, Lechuga-Vieco AV, Alcocer-Gómez E, Castejón-Vega B, Lucas J, Garrido C, Peralta-Garcia A, Pérez-Pulido AJ, Varela-López A, Quiles JL, Ryffel B, Flores I,
Bullón P, Ruiz-Cabello J, Cordero MD.
Aging Cell. 2020 Jan;19(1):e13050. doi: 10.1111/acel.13050. Epub 2019 Oct 18.

miR-590-3p Inhibits Pyroptosis in Diabetic Retinopathy by Targeting NLRP1 and Inactivating the NOX4 Signaling Pathway.
Gu C, Draga D, Zhou C, Su T, Zou C, Gu Q, Lahm T, Zheng Z, Qiu Q.
Invest Ophthalmol Vis Sci. 2019 Oct 1;60(13):4215-4223. doi: 10.1167/iovs.19-27825.

Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation.
Jia C, Zhang J, Chen H, Zhuge Y, Chen H, Qian F, Zhou K, Niu C, Wang F, Qiu H, Wang Z, Xiao J, Rong X, Chu M.
Cell Death Dis. 2019 Oct 14;10(10):778. doi: 10.1038/s41419-019-2021-3.

SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome.
Reitz CJ, Alibhai FJ, Khatua TN, Rasouli M, Bridle BW, Burris TP, Martino TA.
Commun Biol. 2019 Oct 3;2:353. doi: 10.1038/s42003-019-0595-z. eCollection 2019.

NLRP3 inflammasome promotes diabetes-induced endothelial inflammation and atherosclerosis.
Wan Z, Fan Y, Liu X, Xue J, Han Z, Zhu C, Wang X.
Diabetes Metab Syndr Obes. 2019 Sep 20;12:1931-1942. doi: 10.2147/DMSO.S222053. eCollection 201

Taurine Alleviates Schistosoma-Induced Liver Injury by Inhibiting the TXNIP/NLRP3 Inflammasome Signal Pathway and Pyroptosis.
Liu X, Zhang YR, Cai C, Ni XQ, Zhu Q, Ren JL, Chen Y, Zhang LS, Xue CD, Zhao J, Qi YF, Yu YR.
Infect Immun. 2019 Nov 18;87(12). pii: e00732-19. doi: 10.1128/IAI.00732-19. Print 2019 Dec.

α1-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation.
Xin JZ, Wu JM, Hu GM, Gu HJ, Feng YN, Wang SX, Cong WW, Li MZ, Xu WL, Song Y, Xiao H, Zhang YY, Wang L.
Acta Pharmacol Sin. 2020 Mar;41(3):311-318. doi: 10.1038/s41401-019-0305-x. Epub 2019 Sep 17.

Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis.
Wang X, Bian Y, Zhang R, Liu X, Ni L, Ma B, Zeng R, Zhao Z, Song X, Liu C.
Biochem Biophys Res Commun. 2019 Nov 5;519(2):402-408. doi: 10.1016/j.bbrc.2019.09.005. Epub 2019 Sep 11

Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE-/- mice.
Tang G, Duan F, Li W, Wang Y, Zeng C, Hu J, Li H, Zhang X, Chen Y, Tan H.
Biomed Pharmacother. 2019 Nov;119:109410. doi: 10.1016/j.biopha.2019.109410. Epub 2019 Sep 10.

XingNaoJing injections protect against cerebral ischemia/reperfusion injury and alleviate blood-brain barrier disruption in rats, through an underlying mechanism of NLRP3 inflammasomes suppression.
Qu XY, Zhang YM, Tao LN, Gao H, Zhai JH, Sun JM, Song YQ, Zhang SX.
Chin J Nat Med. 2019 Jul;17(7):498-505. doi: 10.1016/S1875-5364(19)30071-8

Cilostazol ameliorates high free fatty acid (FFA)-induced activation of NLRP3 inflammasome in human vascular endothelial cells.
Wang X, Huang H, Su C, Zhong Q, Wu G.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3704-3710. doi: 10.1080/21691401.2019.1665058.

Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1β inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis.
Ridker PM, MacFadyen JG, Thuren T, Libby P.
Eur Heart J. 2019 Sep 1. pii: ehz542. doi: 10.1093/eurheartj/ehz542. [Epub ahead of print]

Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging.
Wang R, Liu L, Liu H, Wu K, Liu Y, Bai L, Wang Q, Qi B, Qi B, Zhang L.
Aging (Albany NY). 2019 Sep 8;11(17):7021-7035. doi: 10.18632/aging.102234. Epub 2019 Sep 8.

Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.
Zhang Q, Zhao S, Zheng W, Fu H, Wu T, Hu F.
Biosci Biotechnol Biochem. 2020 Jan;84(1):134-142. doi: 10.1080/09168451.2019.1664893. Epub 2019 Sep 6.

RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose.
Gao C, Chen J, Fan F, Long Y, Tang S, Jiang C, Wang J, Xu Y, Xu Y.
Mediators Inflamm. 2019 Aug 14;2019:6207563. doi: 10.1155/2019/6207563. eCollection 2019.

Curcumin attenuates migration of vascular smooth muscle cells via inhibiting NFκB-mediated NLRP3expression in spontaneously hypertensive rats.
Han Y, Sun HJ, Tong Y, Chen YZ, Ye C, Qiu Y, Zhang F, Chen AD, Qi XH, Chen Q, Li YH, Kang YM, Zhu GQ.
J Nutr Biochem. 2019 Oct;72:108212. doi: 10.1016/j.jnutbio.2019.07.003. Epub 2019 Jul 8.

Enhanced NLRP3 and DEFA1B Expression During the Active Stage of Parenchymal Neuro-Behçet’s Disease.
Ugurel E, Erdag E, Kucukali CI, Olcay A, Sanli E, Akbayir E, Kurtuncu M, Gunduz T, Yilmaz V, Tuzun E, Vural B.
In Vivo. 2019 Sep-Oct;33(5):1493-1497. doi: 10.21873/invivo.11629.

Atherothrombosis and the NLRP3 inflammasome – endogenous mechanisms of inhibition.
Satish M, Agrawal DK.
Transl Res. 2020 Jan;215:75-85. doi: 10.1016/j.trsl.2019.08.003. Epub 2019 Aug 12. Review.

Inflammation in nonischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3inflammasome signaling.
Suetomi T, Miyamoto S, Brown JH.
Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H877-H890. doi: 10.1152/ajpheart.00223.2019. Epub 2019 Aug 23. Review.

Gastrodin ameliorates microvascular reperfusion injury-induced pyroptosis by regulating the NLRP3/caspase-1 pathway.
Sun W, Lu H, Lyu L, Yang P, Lin Z, Li L, Sun L, Lu D.
J Physiol Biochem. 2019 Nov;75(4):531-547. doi: 10.1007/s13105-019-00702-7. Epub 2019 Aug 22.

Inflammasome activity in leucocytes decreases with abdominal aortic aneurysm progression.
Erhart P, Cakmak S, Grond-Ginsbach C, Hakimi M, Böckler D, Dihlmann S.
Int J Mol Med. 2019 Oct;44(4):1299-1308. doi: 10.3892/ijmm.2019.4307. Epub 2019 Aug 7.

NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium.
Ma P, Zha S, Shen X, Zhao Y, Li L, Yang L, Lei M, Liu W.
Cell Commun Signal. 2019 Aug 20;17(1):102. doi: 10.1186/s12964-019-0406-7.

Klotho improves diabetic cardiomyopathy by suppressing the NLRP3 inflammasome pathway.
Li X, Li Z, Li B, Zhu X, Lai X.
Life Sci. 2019 Oct 1;234:116773. doi: 10.1016/j.lfs.2019.116773. Epub 2019 Aug 15.

Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats.
He Q, Li Z, Meng C, Wu J, Zhao Y, Zhao J.
Cells. 2019 Aug 14;8(8). pii: E897. doi: 10.3390/cells8080897.

Uric acid regulates NLRP3/IL-1β signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux.
Yin W, Zhou QL, OuYang SX, Chen Y, Gong YT, Liang YM.
BMC Nephrol. 2019 Aug 14;20(1):319. doi: 10.1186/s12882-019-1506-8.

Pathogenic role of innate immunity in a model of chronic NO inhibition associated with salt overload.
Zambom FFF, Oliveira KC, Foresto-Neto O, Faustino VD, Ávila VF, Albino AH, Arias SCA, Volpini RA, Malheiros DMAC, Saraiva Camara NO, Zatz R, Fujihara CK.
Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F1058-F1067. doi: 10.1152/ajprenal.00251.2019. Epub 2019 Aug 14.

 17-Allylamino-Demethoxygeldanamycin Ameliorate Microthrombosis Via HSP90/RIP3/NLRP3Pathway After Subarachnoid Hemorrhage in Rats.
Zuo Y, He T, Liao P, Zhuang K, Yan X, Liu F.
Acta Neurochir Suppl. 2020;127:69-75. doi: 10.1007/978-3-030-04615-6_12.

DPP-4 inhibition by linagliptin prevents cardiac dysfunction and inflammation by targeting the Nlrp3/ASC inflammasome.
Birnbaum Y, Tran D, Bajaj M, Ye Y.
Basic Res Cardiol. 2019 Aug 6;114(5):35. doi: 10.1007/s00395-019-0743-0.

FOXP1 suppresses the endothelial NLRP3 inflammasome.
Lim GB.
Nat Rev Cardiol. 2019 Oct;16(10):578-579. doi: 10.1038/s41569-019-0252-8. No abstract available. 

Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3 inflammasome activation in LPS-induced vascular injury.
Zhou X, Wu Y, Ye L, Wang Y, Zhang K, Wang L, Huang Y, Wang L, Xian S, Zhang Y, Chen Y.
Acta Pharm Sin B. 2019 Jul;9(4):711-723. doi: 10.1016/j.apsb.2019.02.008. Epub 2019 Feb 28.

The Inflammasome Adaptor ASC Intrinsically Limits CD4+ T-Cell Proliferation to Help Maintain Intestinal Homeostasis.
Javanmard Khameneh H, Leong KWK, Mencarelli A, Vacca M, Mambwe B, Neo K, Tay A, Zolezzi F, Lee B, Mortellaro A.
Front Immunol. 2019 Jul 15;10:1566. doi: 10.3389/fimmu.2019.01566. eCollection 2019.

Cholesterol-embolization syndrome: current perspectives.
Ozkok A.
Vasc Health Risk Manag. 2019 Jul 8;15:209-220. doi: 10.2147/VHRM.S175150. eCollection 2019. Review.

Cell-Specific Roles of NLRP3 Inflammasome in Myocardial Infarction.
Takahashi M.
J Cardiovasc Pharmacol. 2019 Sep;74(3):188-193. doi: 10.1097/FJC.0000000000000709.

Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases.
An N, Gao Y, Si Z, Zhang H, Wang L, Tian C, Yuan M, Yang X, Li X, Shang H, Xiong X, Xing Y.
Front Immunol. 2019 Jul 10;10:1592. doi: 10.3389/fimmu.2019.01592. eCollection 2019. Review.

Trimethylamine N-Oxide Exacerbates Cardiac Fibrosis via Activating the NLRP3 Inflammasome.
Li X, Geng J, Zhao J, Ni Q, Zhao C, Zheng Y, Chen X, Wang L.
Front Physiol. 2019 Jul 9;10:866. doi: 10.3389/fphys.2019.00866. eCollection 2019.

Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats.
Liang H, Sun Y, Gao A, Zhang N, Jia Y, Yang S, Na M, Liu H, Cheng X, Fang X, Ma W, Zhang X, Wang F.
Int Immunopharmacol. 2019 Oct;75:105771. doi: 10.1016/j.intimp.2019.105771. Epub 2019 Jul 25.

Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and NLRP3inflammasome activation.
Wang Y, Li H, Li Y, Zhao Y, Xiong F, Liu Y, Xue H, Yang Z, Ni S, Sahil A, Che H, Wang L.
Phytother Res. 2019 Oct;33(10):2737-2748. doi: 10.1002/ptr.6448. Epub 2019 Jul 23.

Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications.
Zeng C, Wang R, Tan H.
Int J Biol Sci. 2019 May 20;15(7):1345-1357. doi: 10.7150/ijbs.33568. eCollection 2019. Review.

Macrophage NLRP3 inflammasome activated by CVB3 capsid proteins contributes to the development of viral myocarditis.
Bao J, Sun T, Yue Y, Xiong S.
Mol Immunol. 2019 Oct;114:41-48. doi: 10.1016/j.molimm.2019.07.012. Epub 2019 Jul 20.

The NLRP3 Inflammasome as a Pharmacological Target.
Marchetti C.
J Cardiovasc Pharmacol. 2019 Oct;74(4):285-296. doi: 10.1097/FJC.0000000000000718.

Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes.
Mambwe B, Neo K, Javanmard Khameneh H, Leong KWK, Colantuoni M, Vacca M, Muimo R, Mortellaro A.
Front Immunol. 2019 Jul 5;10:1556. doi: 10.3389/fimmu.2019.01556. eCollection 2019.

Hypothermia Inhibits Cerebral Necroptosis and NOD-Like Receptor Pyrin Domain Containing 3 Pathway in a Swine Model of Cardiac Arrest.
Qian A, Xu J, Wu C, Liu S, Zhang M.
J Surg Res. 2019 Dec;244:468-476. doi: 10.1016/j.jss.2019.05.044. Epub 2019 Jul 19.

Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation.
Darwesh AM, Keshavarz-Bahaghighat H, Jamieson KL, Seubert JM.
Int J Mol Sci. 2019 Jul 17;20(14). pii: E3502. doi: 10.3390/ijms20143502.

FNDC5 inhibits foam cell formation and monocyte adhesion in vascular smooth muscle cells via suppressing NFκB-mediated NLRP3 upregulation.
Zang YH, Chen D, Zhou B, Chen AD, Wang JJ, Gao XY, Chen Q, Li YH, Kang YM, Zhu GQ.
Vascul Pharmacol. 2019 Oct;121:106579. doi: 10.1016/j.vph.2019.106579. Epub 2019 Jul 15.

Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation.
Zhuang T, Liu J, Chen X, Zhang L, Pi J, Sun H, Li L, Bauer R, Wang H, Yu Z, Zhang Q, Tomlinson B, Chan P, Zheng X, Morrisey E, Liu Z, Reilly M, Zhang Y.
Circ Res. 2019 Aug 30;125(6):590-605. doi: 10.1161/CIRCRESAHA.118.314402. Epub 2019 Jul 18.

NLRP3 inflammasome activation is associated with PM2.5 -induced cardiac functional and pathological injury in mice.
Duan S, Wang N, Huang L, Zhao Y, Shao H, Jin Y, Zhang R, Li C, Wu W, Wang J, Feng F.
Environ Toxicol. 2019 Nov;34(11):1246-1254. doi: 10.1002/tox.22825. Epub 2019 Jul 16.

Dulaglutide inhibits high glucose- induced endothelial dysfunction and NLRP3 inflammasome activation.
Luo X, Hu Y, He S, Ye Q, Lv Z, Liu J, Chen X.
Arch Biochem Biophys. 2019 Aug 15;671:203-209. doi: 10.1016/ Epub 2019 Jul 11.

Inflammasome inhibition blocks cardiac glycoside cell toxicity.
LaRock DL, Sands JS, Ettouati E, Richard M, Bushway PJ, Adler ED, Nizet V, LaRock CN.
J Biol Chem. 2019 Aug 23;294(34):12846-12854. doi: 10.1074/jbc.RA119.008330. Epub 2019 Jul 12.

The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction.
Gao R, Shi H, Chang S, Gao Y, Li X, Lv C, Yang H, Xiang H, Yang J, Xu L, Tang Y.
Int Immunopharmacol. 2019 Sep;74:105575. doi: 10.1016/j.intimp.2019.04.022. Epub 2019 Jul 9.

Neuroprotective effect of glycosides in Buyang Huanwu Decoction on pyroptosis following cerebral ischemia-reperfusion injury in rats.
She Y, Shao L, Zhang Y, Hao Y, Cai Y, Cheng Z, Deng C, Liu X.
J Ethnopharmacol. 2019 Oct 5;242:112051. doi: 10.1016/j.jep.2019.112051. Epub 2019 Jul 3.

Calpain silencing alleviates myocardial ischemia-reperfusion injury through the NLRP3/ASC/Caspase-1 axis in mice.
Yue RC, Lu SZ, Luo Y, Wang T, Liang H, Zeng J, Liu J, Hu HX.
Life Sci. 2019 Sep 15;233:116631. doi: 10.1016/j.lfs.2019.116631. Epub 2019 Jul 3.

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies.
Irmscher S, Brix SR, Zipfel SLH, Halder LD, Mutlutürk S, Wulf S, Girdauskas E, Reichenspurner H, Stahl RAK, Jungnickel B, Wiech T, Zipfel PF, Skerka C.
Nat Commun. 2019 Jul 4;10(1):2961. doi: 10.1038/s41467-019-10766-0.

Sulforaphane alleviates retinal ganglion cell death and inflammation by suppressing NLRP3inflammasome activation in a rat model of retinal ischemia/reperfusion injury.
Gong Y, Cao X, Gong L, Li W.
Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419861777. doi: 10.1177/2058738419861777.

NLRP3 inflammasome expression in peripheral blood monocytes of coronary heart disease patients and its modulation by rosuvastatin.
Zhu J, Wu S, Hu S, Li H, Li M, Geng X, Wang H.
Mol Med Rep. 2019 Aug;20(2):1826-1836. doi: 10.3892/mmr.2019.10382. Epub 2019 Jun 13.

Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis.
An P, Xie J, Qiu S, Liu Y, Wang J, Xiu X, Li L, Tang M.
Life Sci. 2019 Sep 1;232:116599. doi: 10.1016/j.lfs.2019.116599. Epub 2019 Jun 25.

Electroacupuncture Alleviates Ischemic Brain Injury by Inhibiting the miR-223/NLRP3 Pathway.
Sha R, Zhang B, Han X, Peng J, Zheng C, Zhang F, Huang X.
Med Sci Monit. 2019 Jun 25;25:4723-4733. doi: 10.12659/MSM.917213.

[Astragaloside IV attenuates cerebral ischemia and reperfusion injury and reduces activation of NLRP3 inflammasome and NF-κB phosphorylation in rats following a transient middle cerebral artery occlusion].
Tang B, Tang WJ, Tang YH, Deng CQ.
Sheng Li Xue Bao. 2019 Jun 25;71(3):424-430. Chinese. 

Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury.
Miyauchi T, Uchida Y, Kadono K, Hirao H, Kawasoe J, Watanabe T, Ueda S, Okajima H, Terajima H, Uemoto S.
Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13533-13542. doi: 10.1073/pnas.1820282116. Epub 2019 Jun 13.

Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal Ischemia/Reperfusion.
Fan X, Du J, Wang MH, Li JM, Yang B, Chen Y, Dai JC, Zhang C, Zhou J.
Oxid Med Cell Longev. 2019 May 2;2019:7857082. doi: 10.1155/2019/7857082. eCollection 2019.

Identification of a de novo NLRP3 gene variation in an Italian Behçet syndrome patient.
Padula MC, Leccese P, Lascaro N, Padula AA, Carbone T, Martelli G, D’Angelo S.
Int J Immunogenet. 2019 Oct;46(5):339-341. doi: 10.1111/iji.12442. Epub 2019 Jun 10.

Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy.
Yang F, Qin Y, Wang Y, Meng S, Xian H, Che H, Lv J, Li Y, Yu Y, Bai Y, Wang L.
Int J Biol Sci. 2019 Mar 10;15(5):1010-1019. doi: 10.7150/ijbs.29680. eCollection 2019.

NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes.
Hong P, Gu RN, Li FX, Xiong XX, Liang WB, You ZJ, Zhang HF.
J Neuroinflammation. 2019 Jun 7;16(1):121. doi: 10.1186/s12974-019-1498-0. Review.

Role of TXNIP/NLRP3 in sepsis-induced myocardial dysfunction.
Yang C, Xia W, Liu X, Lin J, Wu A.
Int J Mol Med. 2019 Aug;44(2):417-426. doi: 10.3892/ijmm.2019.4232. Epub 2019 Jun 6.

Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis.
Tavakoli Dargani Z, Singla DK.
Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H460-H471. doi: 10.1152/ajpheart.00056.2019. Epub 2019 Jun 7

MARK4 (Microtubule Affinity-Regulating Kinase 4)-Dependent Inflammasome Activation Promotes Atherosclerosis-Brief Report.
Clement M, Chen X, Chenoweth HL, Teng Z, Thome S, Newland SA, Harrison J, Yu X, Finigan AJ, Mallat Z, Li X.
Arterioscler Thromb Vasc Biol. 2019 Aug;39(8):1645-1651. doi: 10.1161/ATVBAHA.119.312478. Epub 2019 Jun 6.

The role of inflammasomes in kidney disease.
Komada T, Muruve DA.
Nat Rev Nephrol. 2019 Aug;15(8):501-520. doi: 10.1038/s41581-019-0158-z. Review.

TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI).
Yang XL, Wang X, Shao L, Jiang GT, Min JW, Mei XY, He XH, Liu WH, Huang WX, Peng BW.
J Neuroinflammation. 2019 May 29;16(1):114. doi: 10.1186/s12974-019-1487-3.

HMGB1/RAGE pro-inflammatory axis promotes vascular endothelial cell apoptosis in limb ischemia/reperfusion injury.
Mi L, Zhang Y, Xu Y, Zheng X, Zhang X, Wang Z, Xue M, Jin X.
Biomed Pharmacother. 2019 Aug;116:109005. doi: 10.1016/j.biopha.2019.109005. Epub 2019 May 25.

Role of serum amyloid A in atherosclerosis.
Shridas P, Tannock LR.
Curr Opin Lipidol. 2019 Aug;30(4):320-325. doi: 10.1097/MOL.0000000000000616.

STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3.
Li N, Zhou H, Wu H, Wu Q, Duan M, Deng W, Tang Q.
Redox Biol. 2019 Jun;24:101215. doi: 10.1016/j.redox.2019.101215. Epub 2019 May 13.

NLRP3 inflammasome activity is upregulated in an in-vitro model of COPD exacerbation.
Nachmias N, Langier S, Brzezinski RY, Siterman M, Stark M, Etkin S, Avriel A, Schwarz Y, Shenhar-Tsarfaty S, Bar-Shai A.
PLoS One. 2019 May 21;14(5):e0214622. doi: 10.1371/journal.pone.0214622. eCollection 2019.

NLRP3 inflammasome as a treatment target in atherosclerosis: A focus on statin therapy.
Parsamanesh N, Moossavi M, Bahrami A, Fereidouni M, Barreto G, Sahebkar A.
Int Immunopharmacol. 2019 Aug;73:146-155. doi: 10.1016/j.intimp.2019.05.006. Epub 2019 May 20. Review.

Artemisinin alleviates atherosclerotic lesion by reducing macrophage inflammation via regulation of AMPK/NF-κB/NLRP3 inflammasomes pathway.
Jiang Y, Du H, Liu X, Fu X, Li X, Cao Q.
J Drug Target. 2020 Jan;28(1):70-79. doi: 10.1080/1061186X.2019.1616296. Epub 2019 Jul 16.

The Nlrp3 Inflammasome Orchestrates Mobilization of Bone Marrow-Residing Stem Cells into Peripheral Blood.
Lenkiewicz AM, Adamiak M, Thapa A, Bujko K, Pedziwiatr D, Abdel-Latif AK, Kucia M, Ratajczak J, Ratajczak MZ.
Stem Cell Rev Rep. 2019 Jun;15(3):391-403. doi: 10.1007/s12015-019-09890-7.

Puerarin inhibits vascular calcification of uremic rats.
Liu H, Zhang X, Zhong X, Li Z, Cai S, Yang P, Ou C, Chen M.
Eur J Pharmacol. 2019 Jul 15;855:235-243. doi: 10.1016/j.ejphar.2019.05.023. Epub 2019 May 11.

Potential Therapeutic Value of Interleukin 1b-targeted Strategies in Atherosclerotic Cardiovascular Disease.
Viana-Huete V, Fuster JJ.
Rev Esp Cardiol (Engl Ed). 2019 Sep;72(9):760-766. doi: 10.1016/j.rec.2019.03.006. Epub 2019 May 9. Review. English, Spanish. 

The platelet NLRP3 inflammasome s upregulated in a murine model of pancreatic cancer and promotes platelet aggregation and tumor growth.
Boone BA, Murthy P, Miller-Ocuin JL, Liang X, Russell KL, Loughran P, Gawaz M, Lotze MT, Zeh HJ 3rd, Vogel S.
Ann Hematol. 2019 Jul;98(7):1603-1610. doi: 10.1007/s00277-019-03692-0. Epub 2019 Apr 24.

The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress.
Lei XW, Li Q, Zhang JZ, Zhang YM, Liu Y, Yang KH.
Ophthalmic Res. 2019;62(2):80-92. doi: 10.1159/000499020. Epub 2019 Apr 2

Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome.
Lemarchand E, Barrington J, Chenery A, Haley M, Coutts G, Allen JE, Allan SM, Brough D.
Stroke. 2019 May;50(5):1232-1239. doi: 10.1161/STROKEAHA.118.023620.

NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.
Wang H, Zhong D, Chen H, Jin J, Liu Q, Li G.
Life Sci. 2019 Jun 15;227:101-113. doi: 10.1016/j.lfs.2019.04.031. Epub 2019 Apr 16.

Ectonucleotidase tri(di)phosphohydrolase-1 (ENTPD-1) disrupts inflammasome/interleukin 1β-driven venous thrombosis.
Yadav V, Chi L, Zhao R, Tourdot BE, Yalavarthi S, Jacobs BN, Banka A, Liao H, Koonse S, Anyanwu AC, Visovatti SH, Holinstat MA, Kahlenberg JM, Knight JS, Pinsky DJ, Kanthi Y.
J Clin Invest. 2019 Apr 16;129(7):2872-2877. doi: 10.1172/JCI124804.

Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes.
Ye B, Chen X, Dai S, Han J, Liang X, Lin S, Cai X, Huang Z, Huang W.
Drug Des Devel Ther. 2019 Mar 25;13:975-990. doi: 10.2147/DDDT.S195412. eCollection 2019.

Spleen tyrosine kinase‑induced JNK‑dependent NLRP3 activation is involved in diabetic cardiomyopathy.
Li S, Liu R, Xue M, Qiao Y, Chen Y, Long G, Tian X, Hu Y, Zhou P, Dong X, Qi Z, Cui Y, Shen Y.
Int J Mol Med. 2019 Jun;43(6):2481-2490. doi: 10.3892/ijmm.2019.4148. Epub 2019 Mar 27.

Effects of exercise training on inflammasome-related mediators and their associations to glucometabolic variables in patients with combined coronary artery disease and type 2 diabetes mellitus: Sub-study of a randomized control trial.
Zaidi H, Byrkjeland R, Njerve IU, Åkra S, Solheim S, Arnesen H, Seljeflot I, Opstad TB.
Diab Vasc Dis Res. 2019 Jul;16(4):360-368. doi: 10.1177/1479164119836922. Epub 2019 Apr 3.

IL-1β Plays an Important Role in Pressure Overload-Induced Atrial Fibrillation in Mice.
Matsushita N, Ishida N, Ibi M, Saito M, Takahashi M, Taniguchi S, Iwakura Y, Morino Y, Taira E, Sawa Y, Hirose M.
Biol Pharm Bull. 2019;42(4):543-546. doi: 10.1248/bpb.b18-00363.

Role of NLRP3 Inflammasome in Cardiac Inflammation and Remodeling after Myocardial Infarction.
Takahashi M.
Biol Pharm Bull. 2019;42(4):518-523. doi: 10.1248/bpb.b18-00369. Review.

Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes.
Qiu Z, He Y, Ming H, Lei S, Leng Y, Xia ZY.
J Diabetes Res. 2019 Feb 17;2019:8151836. doi: 10.1155/2019/8151836. eCollection 2019.

Neuromodulatory Effect of NLRP3 and ASC in Neonatal Hypoxic Ischemic Encephalopathy.
Ystgaard MB, Scheffler K, Suganthan R, Bjørås M, Ranheim T, Sagen EL, Halvorsen B, Saugstad OD, Yndestad A.
Neonatology. 2019;115(4):355-362. doi: 10.1159/000497200. Epub 2019 Mar 25.

Obesity and Cardioprotection.
Femminò S, Pagliaro P, Penna C.
Curr Med Chem. 2020;27(2):230-239. doi: 10.2174/0929867326666190325094453

NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs.
Zhang X, Hong S, Qi S, Liu W, Zhang X, Shi Z, Chen W, Zhao M, Yin X.
Mediators Inflamm. 2019 Feb 13;2019:6847087. doi: 10.1155/2019/6847087. eCollection 2019.

Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Leng B, Zhang Y, Liu X, Zhang Z, Liu Y, Wang H, Lu M.
Mediators Inflamm. 2019 Feb 19;2019:1082497. doi: 10.1155/2019/1082497. eCollection 2019.

Periostin contributes to renal and cardiac dysfunction in rats with chronic kidney disease: Reduction of PPARα.
Bian X, Su X, Wang Y, Zhao G, Zhang B, Li D.
Biochimie. 2019 May;160:172-182. doi: 10.1016/j.biochi.2019.03.003. Epub 2019 Mar 16.

Integrated Stress Response Inhibition in Atherosclerosis: Preventing the Stressed-Out Plaque.
Fuster JJ.
J Am Coll Cardiol. 2019 Mar 19;73(10):1170-1172. doi: 10.1016/j.jacc.2019.01.015. No abstract available. 

Activation of Nicotinic Acetylcholine α7 Receptor Attenuates Progression of Monocrotaline-Induced Pulmonary Hypertension in Rats by Downregulating the NLRP3 Inflammasome.
Deng Y, Guo SL, Wei B, Gao XC, Zhou YC, Li JQ.
Front Pharmacol. 2019 Feb 26;10:128. doi: 10.3389/fphar.2019.00128. eCollection 2019.

 Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome.
Xu F, Shen G, Su Z, He Z, Yuan L.
Brain Behav. 2019 Apr;9(4):e01254. doi: 10.1002/brb3.1254. Epub 2019 Mar 11.

Reactive species-induced microvascular dysfunction in ischemia/reperfusion.
Yu H, Kalogeris T, Korthuis RJ.
Free Radic Biol Med. 2019 May 1;135:182-197. doi: 10.1016/j.freeradbiomed.2019.02.031. Epub 2019 Mar 5. Review.

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities.
Bäck M, Yurdagul A Jr, Tabas I, Öörni K, Kovanen PT.
Nat Rev Cardiol. 2019 Jul;16(7):389-406. doi: 10.1038/s41569-019-0169-2. Review.

P2X7 receptor in cardiovascular disease: The heart side.
Guerra Martinez C.
Clin Exp Pharmacol Physiol. 2019 Jun;46(6):513-526. doi: 10.1111/1440-1681.13079. Epub 2019 Apr 7. Review.

Fine particulate matter-induced cardiovascular injury is associated with NLRP3 inflammasome activation in Apo E-/- mice.
Du X, Jiang S, Zeng X, Zhang J, Pan K, Song L, Zhou J, Kan H, Sun Q, Zhao J, Xie Y.
Ecotoxicol Environ Saf. 2019 Jun 15;174:92-99. doi: 10.1016/j.ecoenv.2019.02.064. Epub 2019 Feb 26.

Catheter-based renal sympathetic denervation induces acute renal inflammation through activation of caspase-1 and NLRP3 inflammasome.
Lee DW, Kim JS, Kim IY, Kim HS, Kim JY, Rhee H, Seong EY, Song SH, Lee SB, Edelstein CL, Kwak IS.
Anatol J Cardiol. 2019 Mar;21(3):134-141. doi: 10.14744/AnatolJCardiol.2018.62257.

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia.
Ward R, Li W, Abdul Y, Jackson L, Dong G, Jamil S, Filosa J, Fagan SC, Ergul A.
Pharmacol Res. 2019 Apr;142:237-250. doi: 10.1016/j.phrs.2019.01.035. Epub 2019 Feb 25.

Novel Antiatherosclerotic Therapies.
Libby P, Everett BM.
Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):538-545. doi: 10.1161/ATVBAHA.118.310958. Review.

[Effect of ursolic acid on cardiomyopathy of mice with diabetes and its mechanism].
Yang ZL, Xu HL, Cheng Y, Zhao JG, Zhou YJ, Weng YJ, Wang XT, Qi MY.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2018 Apr 8;34(4):309-312 339. doi: 10.12047/j.cjap.5638.2018.071. Chinese. 

Necrotic cell debris induces a NF-κB-driven inflammasome response in vascular smooth muscle cells derived from abdominal aortic aneurysms (AAA-SMC).
Wortmann M, Skorubskaya E, Peters AS, Hakimi M, Böckler D, Dihlmann S.
Biochem Biophys Res Commun. 2019 Apr 2;511(2):343-349. doi: 10.1016/j.bbrc.2019.02.051. Epub 2019 Feb 16.

Ambient PM2.5 caused depressive-like responses through Nrf2/NLRP3 signaling pathway modulating inflammation.
Chu C, Zhang H, Cui S, Han B, Zhou L, Zhang N, Su X, Niu Y, Chen W, Chen R, Zhang R, Zheng Y.
J Hazard Mater. 2019 May 5;369:180-190. doi: 10.1016/j.jhazmat.2019.02.026. Epub 2019 Feb 10

AIM2 levels and DNA-triggered inflammasome response are increased in peripheral leukocytes of patients with abdominal aortic aneurysm.
Wortmann M, Xiao X, Wabnitz G, Samstag Y, Hakimi M, Böckler D, Dihlmann S.
Inflamm Res. 2019 Apr;68(4):337-345. doi: 10.1007/s00011-019-01212-4. Epub 2019 Feb 13.

Protective Effect of Ethyl Pyruvate against Myocardial Ischemia Reperfusion Injury through Regulations of ROS-Related NLRP3 Inflammasome Activation.
Jun JH, Shim JK, Oh JE, Shin EJ, Shin E, Kwak YL.
Oxid Med Cell Longev. 2019 Jan 9;2019:4264580. doi: 10.1155/2019/4264580. eCollection 2019.

Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy.
Thounaojam MC, Montemari A, Powell FL, Malla P, Gutsaeva DR, Bachettoni A, Ripandelli G, Repossi A, Tawfik A, Martin PM, Facchiano F, Bartoli M.
Diabetes. 2019 May;68(5):1014-1025. doi: 10.2337/db18-0912. Epub 2019 Feb 6.

MCC950 attenuated early brain injury by suppressing NLRP3 inflammasome after experimental SAH in rats.
Luo Y, Lu J, Ruan W, Guo X, Chen S.
Brain Res Bull. 2019 Mar;146:320-326. doi: 10.1016/j.brainresbull.2019.01.027. Epub 2019 Feb 1.

Toxic effects of Cr(VI) on the bovine hemoglobin and human vascular endothelial cells: Molecular interaction and cell damage.
Cao X, Wang S, Bi R, Tian S, Huo Y, Liu J.
Chemosphere. 2019 May;222:355-363. doi: 10.1016/j.chemosphere.2019.01.137. Epub 2019 Jan 24.

nhibition of GSK-3β alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3inflammasome activation through autophagy.
Wang Y, Meng C, Zhang J, Wu J, Zhao J.
Int Immunopharmacol. 2019 Mar;68:234-241. doi: 10.1016/j.intimp.2018.12.042. Epub 2019 Jan 28.

Anticytokine Agents: Targeting Interleukin Signaling Pathways for the Treatment of Atherothrombosis
Ridker PM.
Circ Res. 2019 Feb;124(3):437-450. doi: 10.1161/CIRCRESAHA.118.313129. Review.

Atherosclerosis: perspectives of anti-inflammatory therapy.
Nasonov EL, Popkova TV.
Ter Arkh. 2018 May 11;90(5):4-12. doi: 10.26442/terarkh201890514-12. Review.

NLRP1 inhibiting pathway to be explored in anti-atherosclerosis treatment approach.
Bleda S, De Haro J.
nt J Cardiol. 2019 Mar 1;278:265. doi: 10.1016/j.ijcard.2018.12.082. No abstract available. 

The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Xia Y, Liu N, Xie X, Bi G, Ba H, Li L, Zhang J, Deng X, Yao Y, Tang Z, Yin B, Wang J, Jiang K, Li Z, Choi Y, Gong F, Cheng X, O’Shea JJ, Chae JJ, Laurence A, Yang XP.
Autophagy. 2019 Jun;15(6):960-975. doi: 10.1080/15548627.2019.1569916. Epub 2019 Jan 29.

Resveratrol Suppresses Gut-Derived NLRP3 Inflammasome Partly through Stabilizing Mast Cells in a Rat Model.
Zhao W, Huang X, Han X, Hu D, Hu X, Li Y, Huang P, Yao W.
Mediators Inflamm. 2018 Dec 20;2018:6158671. doi: 10.1155/2018/6158671. eCollection 2018.

The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes.
Sallman DA, List A.
Blood. 2019 Mar 7;133(10):1039-1048. doi: 10.1182/blood-2018-10-844654. Epub 2019 Jan 22. Review.

Anthocyanin is involved in the activation of pyroptosis in oral squamous cell carcinoma.
Yue E, Tuguzbaeva G, Chen X, Qin Y, Li A, Sun X, Dong C, Liu Y, Yu Y, Zahra SM, Shan Q, Jiang Y, Du Z, Bai Y.
Phytomedicine. 2019 Mar 15;56:286-294. doi: 10.1016/j.phymed.2018.09.223. Epub 2018 Sep 26.

The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.
Trotta MC, Maisto R, Guida F, Boccella S, Luongo L, Balta C, D’Amico G, Herman H, Hermenean A, Bucolo C, D’Amico M.
PLoS One. 2019 Jan 18;14(1):e0211005. doi: 10.1371/journal.pone.0211005. eCollection 2019.

Cellular and molecular mechanisms of curcumin in prevention and treatment of disease.
Patel SS, Acharya A, Ray RS, Agrawal R, Raghuwanshi R, Jain P.
Crit Rev Food Sci Nutr. 2020;60(6):887-939. doi: 10.1080/10408398.2018.1552244. Epub 2019 Jan 11. Review.

miRNA-20b inhibits cerebral ischemia-induced inflammation through targeting NLRP3.
Zhao J, Wang H, Dong L, Sun S, Li L.
Int J Mol Med. 2019 Mar;43(3):1167-1178. doi: 10.3892/ijmm.2018.4043. Epub 2018 Dec 31.

Protective effects of sulforaphane on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of NLRP3 inflammasome formation.
Li S, Yang H, Chen X.
Exp Anim. 2019 May 8;68(2):221-231. doi: 10.1538/expanim.18-0146. Epub 2019 Jan 1.

NLRP3 Inflammasome in the Pathophysiology of Hemorrhagic Stroke: A Review.
Luo Y, Reis C, Chen S.
Curr Neuropharmacol. 2019;17(7):582-589. doi: 10.2174/1570159X17666181227170053. Review.

Why Colchicine Should Be Considered for Secondary Prevention of Atherosclerosis: An Overview.
Nidorf SM, Thompson PL.
Clin Ther. 2019 Jan;41(1):41-48. doi: 10.1016/j.clinthera.2018.11.016. Epub 2018 Dec 24. Review.

Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Deficiency in Vascular Smooth Muscle Cells Prevents Arteriovenous Fistula Failure Despite Chronic Kidney Disease.
Ding X, Chen J, Wu C, Wang G, Zhou C, Chen S, Wang K, Zhang A, Ye P, Wu J, Chen S, Zhang H, Xu K, Wang S, Xia J.
J Am Heart Assoc. 2019 Jan 8;8(1):e011211. doi: 10.1161/JAHA.118.011211.

Purple sweet potato color attenuated NLRP3 inflammasome by inducing autophagy to delay endothelial senescence.
Sun C, Diao Q, Lu J, Zhang Z, Wu D, Wang X, Xie J, Zheng G, Shan Q, Fan S, Hu B, Zheng Y.
J Cell Physiol. 2019 May;234(5):5926-5939. doi: 10.1002/jcp.28003. Epub 2018 Dec 26.

Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway.
Liu FY, Cai J, Wang C, Ruan W, Guan GP, Pan HZ, Li JR, Qian C, Chen JS, Wang L, Chen G.
J Neuroinflammation. 2018 Dec 20;15(1):347. doi: 10.1186/s12974-018-1388-x.

Inflammation, Inflammasome Activation, and Atrial Fibrillation.
Van Wagoner DR, Chung MK.
Circulation. 2018 Nov 13;138(20):2243-2246. doi: 10.1161/CIRCULATIONAHA.118.036143. No abstract available. 

Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca2+/Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling.
Suetomi T, Willeford A, Brand CS, Cho Y, Ross RS, Miyamoto S, Brown JH.
Circulation. 2018 Nov 27;138(22):2530-2544. doi: 10.1161/CIRCULATIONAHA.118.034621.

Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome in Cardiovascular Disorders.
Wang Z, Hu W, Lu C, Ma Z, Jiang S, Gu C, Acuña-Castroviejo D, Yang Y.
Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2765-2779. doi: 10.1161/ATVBAHA.118.311916. Review.

Apolipoprotein A-IV may inhibit inflammation via regulating NLRP3/IL-1 path to anti-atherosclerosis.
Peng J, Li XP.
Int J Cardiol. 2019 Mar 1;278:223. doi: 10.1016/j.ijcard.2018.11.103. Epub 2018 Dec 15. No abstract available. 

IL-17A contributes to myocardial ischemic injury by activating NLRP3 inflammasome in macrophages through AMPKα/p38MAPK/ERK1/2 signal pathway in mice.
Zhang L, Liu P, Wen W, Bai X, Zhang Y, Liu M, Wang L, Wu Y, Yuan Z, Zhou J.
Mol Immunol. 2019 Jan;105:240-250. doi: 10.1016/j.molimm.2018.12.014. Epub 2018 Dec 15.

Selective Activation of Cannabinoid Receptor 2 Attenuates Myocardial Infarction via Suppressing NLRP3 Inflammasome.
Yu W, Jin G, Zhang J, Wei W.
Inflammation. 2019 Jun;42(3):904-914. doi: 10.1007/s10753-018-0945-x.

Role of pyroptosis in cardiovascular disease.
Zhaolin Z, Guohua L, Shiyuan W, Zuo W.
Cell Prolif. 2019 Mar;52(2):e12563. doi: 10.1111/cpr.12563. Epub 2018 Dec 7. Review.

Inflammasomes in Clinical Practice: A Brief Introduction.
Alcocer-Gómez E, Castejón-Vega B, López-Sánchez M, Cordero MD.
Exp Suppl. 2018;108:1-8. doi: 10.1007/978-3-319-89390-7_1.

Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease.
Li Y, Liu Y, Yan X, Liu Q, Zhao YH, Wang DW.
Am J Chin Med. 2018;46(8):1727-1741. doi: 10.1142/S0192415X18500878. Epub 2018 Dec 10. Review.

Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Gao W, Wang W, Liu G, Zhang J, Yang J, Deng Z.
Metab Brain Dis. 2019 Feb;34(1):319-329. doi: 10.1007/s11011-018-0342-z. Epub 2018 Dec 4.

Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages.
Chalons P, Amor S, Courtaut F, Cantos-Villar E, Richard T, Auger C, Chabert P, Schni-Kerth V, Aires V, Delmas D.
Nutrients. 2018 Dec 1;10(12). pii: E1856. doi: 10.3390/nu10121856.

SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain.
Tyagi A, Nguyen CU, Chong T, Michel CR, Fritz KS, Reisdorph N, Knaub L, Reusch JEB, Pugazhenthi S.
Sci Rep. 2018 Dec 3;8(1):17547. doi: 10.1038/s41598-018-35890-7.

Salvianolate reduces atrial fibrillation through suppressing atrial interstitial fibrosis by inhibiting TGF-β1/Smad2/3 and TXNIP/NLRP3 inflammasome signaling pathways in post-MI rats.
Qiu H, Liu W, Lan T, Pan W, Chen X, Wu H, Xu D.
Phytomedicine. 2018 Dec 1;51:255-265. doi: 10.1016/j.phymed.2018.09.238. Epub 2018 Oct 4.

Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy.
Ren J, Pei Z, Chen X, Berg MJ, Matrougui K, Zhang QH, Zhang Y.
Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):206-217. doi: 10.1016/j.bbadis.2018.08.017. Epub 2018 Aug 16.

Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation.
Zhong W, Li B, Xu Y, Yang P, Chen R, Wang Z, Shao C, Song J, Yan J.
JACC Basic Transl Sci. 2018 Sep 19;3(5):604-624. doi: 10.1016/j.jacbts.2018.06.004. eCollection 2018 Oct.

An Orally Available NLRP3 Inflammasome Inhibitor Prevents Western Diet-Induced Cardiac Dysfunction in Mice.
Carbone S, Mauro AG, Prestamburgo A, Halquist MS, Narayan P, Potere N, Mezzaroma E, Van Tassell BW, Abbate A, Toldo S.
J Cardiovasc Pharmacol. 2018 Dec;72(6):303-307. doi: 10.1097/FJC.0000000000000628.

Prostaglandin E2/EP2 receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes.
Wang M, Wang Y, Xie T, Zhan P, Zou J, Nie X, Shao J, Zhuang M, Tan C, Tan J, Dai Y, Sun J, Li J, Li Y, Shi Q, Leng J, Wang X, Yao Y.
Diabetologia. 2019 Feb;62(2):335-348. doi: 10.1007/s00125-018-4755-3. Epub 2018 Nov 8.

AC-YVAD-CMK Inhibits Pyroptosis and Improves Functional Outcome after Intracerebral Hemorrhage.
Lin X, Ye H, Siaw-Debrah F, Pan S, He Z, Ni H, Xu Z, Jin K, Zhuge Q, Huang L.
Biomed Res Int. 2018 Oct 16;2018:3706047. doi: 10.1155/2018/3706047. eCollection 2018.

Endogenous muscle atrophy F-box is involved in the development of cardiac rupture after myocardial infarction.
Usui S, Chikata A, Takatori O, Takashima SI, Inoue O, Kato T, Murai H, Furusho H, Nomura A, Zablocki D, Kaneko S, Sadoshima J, Takamura M.
J Mol Cell Cardiol. 2019 Jan;126:1-12. doi: 10.1016/j.yjmcc.2018.11.002. Epub 2018 Nov 6.

The renal immune-inflammatory component of arterial hypertension: emerging therapeutic strategies.
Garcia-Fernandez N, Beaumont J, Moreno MU, San José G, González A, Díez J.
Cardiovasc Res. 2019 Mar 15;115(4):696-698. doi: 10.1093/cvr/cvy280. No abstract available. 

Puerarin inhibits hyperglycemia-induced inter-endothelial junction through suppressing endothelial Nlrp3 inflammasome activation via ROS-dependent oxidative pathway.
Lian D, Yuan H, Yin X, Wu Y, He R, Huang Y, Chen Y.
Phytomedicine. 2019 Mar 1;55:310-319. doi: 10.1016/j.phymed.2018.10.013. Epub 2018 Oct 11.

Estrogen ameliorates allergic airway inflammation by regulating activation of NLRP3 in mice.
Cheng C, Wu H, Wang M, Wang L, Zou H, Li S, Liu R.
Biosci Rep. 2019 Jan 8;39(1). pii: BSR20181117. doi: 10.1042/BSR20181117. Print 2019 Jan 31.

Activation of NLRP3 Inflammasome Promotes Foam Cell Formation in Vascular Smooth Muscle Cells and Atherogenesis Via HMGB1.
Wang R, Wu W, Li W, Huang S, Li Z, Liu R, Shan Z, Zhang C, Li W, Wang S.
J Am Heart Assoc. 2018 Oct 2;7(19):e008596. doi: 10.1161/JAHA.118.008596.

Cathepsin B-Mediated NLRP3 Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion Dysfunction.
Lian D, Lai J, Wu Y, Wang L, Chen Y, Zhang Y, Boini KM, Huang Y, Chen Y.
Cell Physiol Biochem. 2018;50(4):1585-1600. doi: 10.1159/000494656. Epub 2018 Oct 25.

Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis.
Tamura N, Maejima Y, Matsumura T, Vega RB, Amiya E, Ito Y, Shiheido-Watanabe Y, Ashikaga T, Komuro I, Kelly DP, Hirao K, Isobe M.
Circ Genom Precis Med. 2018 Oct;11(10):e002296. doi: 10.1161/CIRCGEN.118.002296.

Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow.
Wakabayashi T, Takahashi M, Yamamuro D, Karasawa T, Takei A, Takei S, Yamazaki H, Nagashima S, Ebihara K, Takahashi M, Ishibashi S.
Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2576-2589. doi: 10.1161/ATVBAHA.118.311648.

Microglial Mincle receptor in the PVN contributes to sympathetic hyperactivity in acute myocardial infarction rat.
Wang Y, Yin J, Wang C, Hu H, Li X, Xue M, Liu J, Cheng W, Wang Y, Li Y, Shi Y, Tan J, Li X, Liu F, Liu Q, Yan S.
J Cell Mol Med. 2019 Jan;23(1):112-125. doi: 10.1111/jcmm.13890. Epub 2018 Oct 24.

Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Liu H, Sun Y, Zhang Y, Yang G, Guo L, Zhao Y, Pei Z.
Inflammation. 2019 Apr;42(2):516-525. doi: 10.1007/s10753-018-0909-1.

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension.
Chakraborty S, Galla S, Cheng X, Yeo JY, Mell B, Singh V, Yeoh B, Saha P, Mathew AV, Vijay-Kumar M, Joe B.
Cell Rep. 2018 Oct 16;25(3):677-689.e4. doi: 10.1016/j.celrep.2018.09.058.

Update on pathological platelet activation in coronary thrombosis.
Elia E, Montecucco F, Portincasa P, Sahebkar A, Mollazadeh H, Carbone F.
J Cell Physiol. 2019 Mar;234(3):2121-2133. doi: 10.1002/jcp.27575. Epub 2018 Oct 14. Review.

Spotlight on the NLRP3 inflammasome pathway.
Groslambert M, Py BF.
J Inflamm Res. 2018 Sep 25;11:359-374. doi: 10.2147/JIR.S141220. eCollection 2018. Review.

The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice.
Sogawa Y, Nagasu H, Itano S, Kidokoro K, Taniguchi S, Takahashi M, Kadoya H, Satoh M, Sasaki T, Kashihara N.
PLoS One. 2018 Oct 3;13(10):e0203823. doi: 10.1371/journal.pone.0203823. eCollection 2018.

Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review).
Ma C, Liu S, Zhang S, Xu T, Yu X, Gao Y, Zhai C, Li C, Lei C, Fan S, Chen Y, Tian H, Wang Q, Cheng F, Wang X.
Int J Mol Med. 2018 Dec;42(6):2979-2990. doi: 10.3892/ijmm.2018.3911. Epub 2018 Oct 2. Review.

Sulfur dioxide attenuates sepsis-induced cardiac dysfunction via inhibition of NLRP3 inflammasome activation in rats.
Yang L, Zhang H, Chen P.
Nitric Oxide. 2018 Dec 1;81:11-20. doi: 10.1016/j.niox.2018.09.005. Epub 2018 Sep 28.

Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries.
Yuan X, Bhat OM, Meng N, Lohner H, Li PL.
Am J Pathol. 2018 Dec;188(12):2948-2959. doi: 10.1016/j.ajpath.2018.08.014. Epub 2018 Sep 29.

Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3Inflammasome Inhibition.
Ma S, Chen J, Feng J, Zhang R, Fan M, Han D, Li X, Li C, Ren J, Wang Y, Cao F.
Oxid Med Cell Longev. 2018 Sep 4;2018:9286458. doi: 10.1155/2018/9286458. eCollection 2018.

Evaluation on the effect of hydrogen sulfide on the NLRP3 signaling pathway and its involvement in the pathogenesis of atherosclerosis.
Yue LM, Gao YM, Han BH.
J Cell Biochem. 2019 Jan;120(1):481-492. doi: 10.1002/jcb.27404. Epub 2018 Sep 23.

Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction.
Li X, Wang T, Zhang D, Li H, Shen H, Ding X, Chen G.
Neuropharmacology. 2018 Oct;141:305-315. doi: 10.1016/j.neuropharm.2018.09.015. Epub 2018 Sep 12.

Donor heart preservation with a novel long-term and slow-releasing hydrogen sulfide system.
Sun X, Wang W, Dai J, Huang J, Shi M, Chu X, Wang F, Guo C, Wang C, Pang L, Wang Y.
Nitric Oxide. 2018 Dec 1;81:1-10. doi: 10.1016/j.niox.2018.09.001. Epub 2018 Sep 11.

Toll-Like Receptor 4 and NLRP3 Caspase 1- Interleukin-1β-Axis are Not Involved in Colon Ascendens Stent Peritonitis-Associated Heart Disease.
Alarcón MML, Ruocco JF, Ferreira F, Paula-Neto HA, Sepúlveda M, Vila Petroff M, Carvalho AB, Ramos IP, Branda HJ, Paiva CN, Medei E.
Shock. 2018 Oct;50(4):483-492. doi: 10.1097/SHK.0000000000001059.

The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma.
Zhao X, Hua M, Yan S, Yu J, Han F, Zhong C, Wang R, Zhang C, Hou M, Ma D.
J Immunol Res. 2018 Aug 23;2018:7569809. doi: 10.1155/2018/7569809. eCollection 2018.

Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells.
Jiang C, Jiang L, Li Q, Liu X, Zhang T, Dong L, Liu T, Liu L, Hu G, Sun X, Jiang L.
Toxicology. 2018 Dec 1;410:26-40. doi: 10.1016/j.tox.2018.09.002. Epub 2018 Sep 8.

Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke.
Poh L, Kang SW, Baik SH, Ng GYQ, She DT, Balaganapathy P, Dheen ST, Magnus T, Gelderblom M, Sobey CG, Koo EH, Fann DY, Arumugam TV.
Brain Behav Immun. 2019 Jan;75:34-47. doi: 10.1016/j.bbi.2018.09.001. Epub 2018 Sep 5.

Pretreatment with low-dose fimasartan ameliorates NLRP3 inflammasome-mediated neuroinflammation and brain injury after intracerebral hemorrhage.
Yang X, Sun J, Kim TJ, Kim YJ, Ko SB, Kim CK, Jia X, Yoon BW.
Exp Neurol. 2018 Dec;310:22-32. doi: 10.1016/j.expneurol.2018.08.013. Epub 2018 Aug 29.

MicroRNA-495 Ameliorates Cardiac Microvascular Endothelial Cell Injury and Inflammatory Reaction by Suppressing the NLRP3 Inflammasome Signaling Pathway.
Zhou T, Xiang DK, Li SN, Yang LH, Gao LF, Feng C.
Cell Physiol Biochem. 2018;49(2):798-815. doi: 10.1159/000493042. Epub 2018 Aug 30.

 NF-κB-Gasdermin D (GSDMD) Axis Couples Oxidative Stress and NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3) Inflammasome-Mediated Cardiomyocyte Pyroptosis Following Myocardial Infarction.
Lei Q, Yi T, Chen C.
Med Sci Monit. 2018 Aug 30;24:6044-6052. doi: 10.12659/MSM.908529.

NLRP3 deficiency accelerates pressure overload-induced cardiac remodeling via increased TLR4 expression.
Li F, Zhang H, Yang L, Yong H, Qin Q, Tan M, Xu L, Liang K, Zong J, Qian W.
J Mol Med (Berl). 2018 Nov;96(11):1189-1202. doi: 10.1007/s00109-018-1691-0. Epub 2018 Aug 29.

Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38/JNK Pathway and Peripheral Obliterans in Rats.
Guo H, Sun L, Ling S, Xu JW.
Mediators Inflamm. 2018 Aug 12;2018:7304096. doi: 10.1155/2018/7304096. eCollection 2018.

RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD.
Chen H, Fang Y, Wu J, Chen H, Zou Z, Zhang X, Shao J, Xu Y.
Cell Death Dis. 2018 Aug 29;9(9):878. doi: 10.1038/s41419-018-0936-8.

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury.
Gong Z, Pan J, Shen Q, Li M, Peng Y.
J Neuroinflammation. 2018 Aug 28;15(1):242. doi: 10.1186/s12974-018-1282-6.

Rosmarinic acid inhibits nicotine-induced C-reactive protein generation by inhibiting NLRP3inflammasome activation in smooth muscle cells.
Yao Y, Mao J, Xu S, Zhao L, Long L, Chen L, Li D, Lu S.
J Cell Physiol. 2019 Feb;234(2):1758-1767. doi: 10.1002/jcp.27046. Epub 2018 Aug 26.

The selective Nlrp3 inflammasome inhibitor Mcc950 attenuates lung ischemia-reperfusion injury.
Xu KY, Wu CY, Tong S, Xiong P, Wang SH.
Biochem Biophys Res Commun. 2018 Sep 18;503(4):3031-3037. doi: 10.1016/j.bbrc.2018.08.089. Epub 2018 Aug 23.

PPARγ Deficiency Suppresses the Release of IL-1β and IL-1α in Macrophages via a Type 1 IFN-Dependent Mechanism.
Weber KJ, Sauer M, He L, Tycksen E, Kalugotla G, Razani B, Schilling JD.
J Immunol. 2018 Oct 1;201(7):2054-2069. doi: 10.4049/jimmunol.1800224. Epub 2018 Aug 24.

Prostaglandin E2 Activates NLRP3 Inflammasome in Endothelial Cells to Promote Diabetic Retinopathy.
Wang Y, Tao J, Yao Y.
Horm Metab Res. 2018 Sep;50(9):704-710. doi: 10.1055/a-0664-0699. Epub 2018 Aug 24.

The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease.
Xu Y, Zhang J, Ma L, Zhao S, Li S, Huang T, Chu Z.
Behav Neurol. 2018 Jul 22;2018:6814393. doi: 10.1155/2018/6814393. eCollection 2018. Review.

MicroRNA-30c-5p inhibits NLRP3 inflammasome-mediated endothelial cell pyroptosis through FOXO3 down-regulation in atherosclerosis.
Li P, Zhong X, Li J, Liu H, Ma X, He R, Zhao Y.
Biochem Biophys Res Commun. 2018 Sep 18;503(4):2833-2840. doi: 10.1016/j.bbrc.2018.08.049. Epub 2018 Aug 6.

Renoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats.
Kim SH, Jun JH, Oh JE, Shin EJ, Oh YJ, Choi YS.
PLoS One. 2018 Aug 16;13(8):e0198307. doi: 10.1371/journal.pone.0198307. eCollection 2018.

The role of NLRP3 inflammasome in stroke and central poststroke pain.
Li SJ, Zhang YF, Ma SH, Yi Y, Yu HY, Pei L, Feng D.
Medicine (Baltimore). 2018 Aug;97(33):e11861. doi: 10.1097/MD.0000000000011861. Review. Erratum in: Medicine (Baltimore). 2018 Nov;97(47):e13495

Role of NLRP-3 Inflammasome in Hypertension: A Potential Therapeutic Target.
Pasqua T, Pagliaro P, Rocca C, Angelone T, Penna C.
Curr Pharm Biotechnol. 2018;19(9):708-714. doi: 10.2174/1389201019666180808162011. Review.

Antineuroinflammatory Effect of SMTP-7 in Ischemic Mice.
Huang Y, Ohta Y, Shang J, Morihara R, Nakano Y, Fukui Y, Liu X, Shi X, Feng T, Yamashita T, Sato K, Takemoto M, Hishikawa N, Suzuki E, Hasumi K, Abe K.
J Stroke Cerebrovasc Dis. 2018 Nov;27(11):3084-3094. doi: 10.1016/j.jstrokecerebrovasdis.2018.06.039. Epub 2018 Aug 3.

Ozone protects the rat lung from ischemia-reperfusion injury by attenuating NLRP3-mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis.
Wang Z, Zhang A, Meng W, Wang T, Li D, Liu Z, Liu H.
Eur J Pharmacol. 2018 Sep 15;835:82-93. doi: 10.1016/j.ejphar.2018.07.059. Epub 2018 Jul 31.

DHA attenuates hepatic ischemia reperfusion injury by inhibiting pyroptosis and activating PI3K/Akt pathway.
Li Z, Zhao F, Cao Y, Zhang J, Shi P, Sun X, Zhang F, Tong L.
Eur J Pharmacol. 2018 Sep 15;835:1-10. doi: 10.1016/j.ejphar.2018.07.054. Epub 2018 Jul 31.

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty.
Ferrucci L, Fabbri E.
Nat Rev Cardiol. 2018 Sep;15(9):505-522. doi: 10.1038/s41569-018-0064-2. Review.

Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients.
Pereira NS, Queiroga TBD, Nunes DF, Andrade CM, Nascimento MSL, Do-Valle-Matta MA, da Câmara ACJ, Galvão LMDC, Guedes PMM, Chiari E.
PLoS Negl Trop Dis. 2018 Jul 25;12(7):e0006589. doi: 10.1371/journal.pntd.0006589. eCollection 2018 Jul.

Protection of Anthocyanin from Myrica rubra against Cerebral Ischemia-Reperfusion Injury via Modulation of the TLR4/NF-κB and NLRP3 Pathways.
Cui HX, Chen JH, Li JW, Cheng FR, Yuan K.
Molecules. 2018 Jul 20;23(7). pii: E1788. doi: 10.3390/molecules23071788.

Ginkgolide B ameliorates NLRP3 inflammasome activation after hypoxic-ischemic brain injury in the neonatal male rat.
Chen A, Xu Y, Yuan J.
Int J Dev Neurosci. 2018 Oct;69:106-111. doi: 10.1016/j.ijdevneu.2018.07.004. Epub 2018 Jul 17.

Peperomin E (PepE) protects against high fat diet-induced atherosclerosis in Apolipoprotein E deficient (ApoE-/-) mice through reducing inflammation via the suppression of NLRP3 signaling pathway.
Yan J, Li M, Wang XD, Lu ZY, Ni XL.
Biomed Pharmacother. 2018 Sep;105:862-869. doi: 10.1016/j.biopha.2018.04.140. Epub 2018 Jun 18.

Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via NLRP3 inflammasome/IL-1 signaling pathway.
Zhu X, Zhang HW, Chen HN, Deng XJ, Tu YX, Jackson AO, Qing JN, Wang AP, Patel V, Yin K.
Acta Pharmacol Sin. 2019 Jan;40(1):46-54. doi: 10.1038/s41401-018-0068-9. Epub 2018 Jul 12.

Gypenosides improve diabetic cardiomyopathy by inhibiting ROS-mediated NLRP3 inflammasome activation.
Zhang H, Chen X, Zong B, Yuan H, Wang Z, Wei Y, Wang X, Liu G, Zhang J, Li S, Cheng G, Wang Y, Ma Y.
J Cell Mol Med. 2018 Sep;22(9):4437-4448. doi: 10.1111/jcmm.13743. Epub 2018 Jul 11.

Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation.
Liu S, Tian L, Chai G, Wen B, Wang B.
Food Funct. 2018 Aug 15;9(8):4184-4193. doi: 10.1039/c8fo00650d.

Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis.
Rashad S, Niizuma K, Sato-Maeda M, Fujimura M, Mansour A, Endo H, Ikawa S, Tominaga T.
Brain Res. 2018 Nov 15;1699:54-68. doi: 10.1016/j.brainres.2018.06.029. Epub 2018 Jul 5.

Lipid lowering drugs and inflammatory changes: an impact on cardiovascular outcomes?
Ruscica M, Ferri N, Macchi C, Corsini A, Sirtori CR.
Ann Med. 2018 Sep;50(6):461-484. doi: 10.1080/07853890.2018.1498118. Epub 2018 Oct 15.

Initiation of the inflammatory response after renal ischemia/reperfusion injury during renal transplantation.
Gu L, Tao Y, Chen C, Ye Y, Xiong X, Sun Y.
Int Urol Nephrol. 2018 Nov;50(11):2027-2035. doi: 10.1007/s11255-018-1918-6. Epub 2018 Jul 4. Review.

Interleukin-18 and the NLR family pyrin domain containing-3 inflammasome in adipose tissue are strongly associated with glucometabolic variables in a cohort of middle-aged men.
Åkra S, Aksnes TA, Flaa A, Eggesbø HB, Opstad TB, Njerve IU, Seljeflot I.
Diab Vasc Dis Res. 2018 Sep;15(5):458-464. doi: 10.1177/1479164118785307. Epub 2018 Jul 4.

NLRP3 inflammasome mediates chronic intermittent hypoxia-induced renal injury implication of the microRNA-155/FOXO3a signaling pathway.
Wu X, Chang SC, Jin J, Gu W, Li S.
J Cell Physiol. 2018 Dec;233(12):9404-9415. doi: 10.1002/jcp.26784. Epub 2018 Jun 28.

Effects of the TLR4/Myd88/NF-κB Signaling Pathway on NLRP3 Inflammasome in Coronary Microembolization-Induced Myocardial Injury.
Su Q, Li L, Sun Y, Yang H, Ye Z, Zhao J.
Cell Physiol Biochem. 2018;47(4):1497-1508. doi: 10.1159/000490866. Epub 2018 Jun 21.

Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis.
Tumurkhuu G, Dagvadorj J, Porritt RA, Crother TR, Shimada K, Tarling EJ, Erbay E, Arditi M, Chen S.
Cell Metab. 2018 Sep 4;28(3):432-448.e4. doi: 10.1016/j.cmet.2018.05.027. Epub 2018 Jun 21.

Physical activity protects NLRP3 inflammasome-associated coronary vascular dysfunction in obese mice.
Lee J, Lee Y, LaVoy EC, Umetani M, Hong J, Park Y.
Physiol Rep. 2018 Jun;6(12):e13738. doi: 10.14814/phy2.13738.

CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis.
Willeford A, Suetomi T, Nickle A, Hoffman HM, Miyamoto S, Heller Brown J.
JCI Insight. 2018 Jun 21;3(12). pii: 97054. doi: 10.1172/jci.insight.97054. eCollection 2018 Jun 21.

Role of complement C5a and histones in septic cardiomyopathy.
Fattahi F, Frydrych LM, Bian G, Kalbitz M, Herron TJ, Malan EA, Delano MJ, Ward PA.
Mol Immunol. 2018 Oct;102:32-41. doi: 10.1016/j.molimm.2018.06.006. Epub 2018 Jun 18. Review.

Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome.
Wan Y, Xu L, Wang Y, Tuerdi N, Ye M, Qi R.
Eur J Pharmacol. 2018 Aug 15;833:545-554. doi: 10.1016/j.ejphar.2018.06.016. Epub 2018 Jun 18.

Inflammasome activation in AF.
Fernández-Ruiz I.
Nat Rev Cardiol. 2018 Aug;15(8):442. doi: 10.1038/s41569-018-0045-5. No abstract available. 

l-Homocarnosine attenuates inflammation in cerebral ischemia-reperfusion injury through inhibition of nod-like receptor protein 3 inflammasome.
Huang J, Wang T, Yu D, Fang X, Fan H, Liu Q, Yi G, Yi X, Liu Q.
Int J Biol Macromol. 2018 Oct 15;118(Pt A):357-364. doi: 10.1016/j.ijbiomac.2018.06.032. Epub 2018 Jun 8.

Intracellular organelles in health and kidney disease.
Shamekhi Amiri F.
Nephrol Ther. 2019 Mar;15(1):9-21. doi: 10.1016/j.nephro.2018.04.002. Epub 2018 Jun 8. Review.

Acceleration of NLRP3 inflammasome by chronic cerebral hypoperfusion in Alzheimer’s diseasemodel mouse.
Shang J, Yamashita T, Zhai Y, Nakano Y, Morihara R, Li X, Tian F, Liu X, Huang Y, Shi X, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K.
Neurosci Res. 2019 Jun;143:61-70. doi: 10.1016/j.neures.2018.06.002. Epub 2018 Jun 6.

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis.
Grebe A, Hoss F, Latz E.
Circ Res. 2018 Jun 8;122(12):1722-1740. doi: 10.1161/CIRCRESAHA.118.311362. Review.

Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization.
Fulp J, He L, Toldo S, Jiang Y, Boice A, Guo C, Li X, Rolfe A, Sun D, Abbate A, Wang XY, Zhang S.
J Med Chem. 2018 Jun 28;61(12):5412-5423. doi: 10.1021/acs.jmedchem.8b00733. Epub 2018 Jun 18.

Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.
Lau A, Chung H, Komada T, Platnich JM, Sandall CF, Choudhury SR, Chun J, Naumenko V, Surewaard BG, Nelson MC, Ulke-Lemée A, Beck PL, Benediktsson H, Jevnikar AM, Snelgrove SL, Hickey MJ, Senger DL, James MT, Macdonald JA, Kubes P, Jenne CN, Muruve DA.
J Clin Invest. 2018 Jul 2;128(7):2894-2913. doi: 10.1172/JCI96640. Epub 2018 Jun 4.

Dexmedetomidine attenuates traumatic brain injury: action pathway and mechanisms.
Wang D, Xu X, Wu YG, Lyu L, Zhou ZW, Zhang JN.
Neural Regen Res. 2018 May;13(5):819-826. doi: 10.4103/1673-5374.232529.

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury.
Xu X, Yin D, Ren H, Gao W, Li F, Sun D, Wu Y, Zhou S, Lyu L, Yang M, Xiong J, Han L, Jiang R, Zhang J.
Neurobiol Dis. 2018 Sep;117:15-27. doi: 10.1016/j.nbd.2018.05.016. Epub 2018 May 30.

Hydrogen sulfide attenuates oxidative stress-induced NLRP3 inflammasome activation via S-sulfhydrating c-Jun at Cys269 in macrophages.
Lin Z, Altaf N, Li C, Chen M, Pan L, Wang D, Xie L, Zheng Y, Fu H, Han Y, Ji Y.
Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2890-2900. doi: 10.1016/j.bbadis.2018.05.023. Epub 2018 May 30.

Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice.
Hong P, Li FX, Gu RN, Fang YY, Lai LY, Wang YW, Tao T, Xu SY, You ZJ, Zhang HF.
Neural Plast. 2018 Apr 24;2018:9163521. doi: 10.1155/2018/9163521. eCollection 2018.

NLRP3: A Novel Mediator in Cardiovascular Disease.
Zhou W, Chen C, Chen Z, Liu L, Jiang J, Wu Z, Zhao M, Chen Y.
J Immunol Res. 2018 Apr 8;2018:5702103. doi: 10.1155/2018/5702103. eCollection 2018. Review.

Rs4612666 Polymorphism of the NLRP3 Gene Is Associated with the Occurrence of Large Artery Atherosclerotic Ischemic Strokes and Microembolic Signals.
Cheng L, Yin R, Yang S, Pan X, Ma A.
Biomed Res Int. 2018 Apr 23;2018:6345805. doi: 10.1155/2018/6345805. eCollection 2018.

17β-Estradiol Regulates Microglia Activation and Polarization in the Hippocampus Following Global Cerebral Ischemia.
Thakkar R, Wang R, Wang J, Vadlamudi RK, Brann DW.
Oxid Med Cell Longev. 2018 Apr 18;2018:4248526. doi: 10.1155/2018/4248526. eCollection 2018.

Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-κB pathway and the NLRP3 inflammasome may be involved in the mechanism.
Yin D, Zhou S, Xu X, Gao W, Li F, Ma Y, Sun D, Wu Y, Guo Q, Liu H, Han L, Wang Z, Wang Y, Zhang J.
Brain Res. 2018 Nov 1;1698:1-10. doi: 10.1016/j.brainres.2018.05.040. Epub 2018 May 26.

NLRP3 Inflammasome Is Involved in Q-VD-OPH Induced Necroptosis Following Cerebral Ischemia-Reperfusion Injury.
Teng X, Chen W, Liu Z, Feng T, Li H, Ding S, Chen Y, Zhang Y, Tang X, Geng D.
Neurochem Res. 2018 Jun;43(6):1200-1209. doi: 10.1007/s11064-018-2537-4. Epub 2018 May 25.

Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation.
Yao C, Veleva T, Scott L Jr, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I Dr, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, Müller FU, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N.
Circulation. 2018 Nov 13;138(20):2227-2242. doi: 10.1161/CIRCULATIONAHA.118.035202. Erratum in: Circulation. 2019 Apr 23;139(17):e889

sRAGE attenuates angiotensin II-induced cardiomyocyte hypertrophy by inhibiting RAGE-NFκB-NLRP3 activation.
Lim S, Lee ME, Jeong J, Lee J, Cho S, Seo M, Park S.
Inflamm Res. 2018 Aug;67(8):691-701. doi: 10.1007/s00011-018-1160-9. Epub 2018 May 23.

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis.
Qiao J, Wu X, Luo Q, Wei G, Xu M, Wu Y, Liu Y, Li X, Zi J, Ju W, Fu L, Chen C, Wu Q, Zhu S, Qi K, Li D, Li Z, Andrews RK, Zeng L, Gardiner EE, Xu K.
Haematologica. 2018 Sep;103(9):1568-1576. doi: 10.3324/haematol.2018.191700. Epub 2018 May 24.

Inhibition of Interleukin-1β by Canakinumab and Cardiovascular Outcomes in Patients With Chronic Kidney Disease.
Ridker PM, MacFadyen JG, Glynn RJ, Koenig W, Libby P, Everett BM, Lefkowitz M, Thuren T, Cornel JH.
J Am Coll Cardiol. 2018 May 29;71(21):2405-2414. doi: 10.1016/j.jacc.2018.03.490.

Methylene blue attenuates renal ischemia-reperfusion injury by negative regulation of NLRP3signaling pathway.
Liu JJ, Lu L, Hu FQ, Yuan H, Xu Q, Qin YF, Gong JH.
Eur Rev Med Pharmacol Sci. 2018 May;22(9):2847-2853. doi: 10.26355/eurrev_201805_14986.

Simvastatin Suppresses Interleukin Iβ Release in Human Peripheral Blood Mononuclear Cells Stimulated With Cholesterol Crystals.
Boland AJ, Gangadharan N, Kavanagh P, Hemeryck L, Kieran J, Barry M, Walsh PT, Lucitt M.
J Cardiovasc Pharmacol Ther. 2018 Nov;23(6):509-517. doi: 10.1177/1074248418776261. Epub 2018 May 15.

Transient postnatal over nutrition induces long-term alterations in cardiac NLRP3-inflammasome pathway.
Siddeek B, Li N, Mauduit C, Chehade H, Rigal E, Tolsa JF, Armengaud JB, Yzydorczyk C, Benahmed M, Vergely C, Simeoni U.
Nutr Metab Cardiovasc Dis. 2018 Sep;28(9):944-951. doi: 10.1016/j.numecd.2018.03.013. Epub 2018 Apr 14.

Apelin protects against sepsis‑induced cardiomyopathy by inhibiting the TLR4 and NLRP3 signaling pathways.
Luo Q, Liu G, Chen G, Guo D, Xu L, Hang M, Jin M.
Int J Mol Med. 2018 Aug;42(2):1161-1167. doi: 10.3892/ijmm.2018.3665. Epub 2018 May 9.

Artesunate Inhibits Renal Ischemia-Reperfusion-Mediated Remote Lung Inflammation Through Attenuating ROS-Induced Activation of NLRP3 Inflammasome.
Liu Z, Qu M, Yu L, Song P, Chang Y.
Inflammation. 2018 Aug;41(4):1546-1556. doi: 10.1007/s10753-018-0801-z.

Inflammation and atherosclerosis: Cardiovascular evaluation in patients with autoimmune diseases.
Escárcega RO, Lipinski MJ, García-Carrasco M, Mendoza-Pinto C, Galvez-Romero JL, Cervera R.
Autoimmun Rev. 2018 Jul;17(7):703-708. doi: 10.1016/j.autrev.2018.01.021. Epub 2018 May 3. Review.

Mitochondrial Autophagy and NLRP3 Inflammasome in Pulmonary Tissues from Severe Combined Immunodeficient Mice after Cardiac Arrest and Cardiopulmonary Resuscitation.
Lyu JJ, Mehta JL, Li Y, Ye L, Sun SN, Sun HS, Li JC, Zhang DM, Wei J.
Chin Med J (Engl). 2018 May 20;131(10):1174-1184. doi: 10.4103/0366-6999.231519.

Vitamin D3 Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROS/TXNIP/NLRP3 Inflammasome Pathway.
Lu L, Lu Q, Chen W, Li J, Li C, Zheng Z.
J Diabetes Res. 2018 Feb 22;2018:8193523. doi: 10.1155/2018/8193523. eCollection 2018.

Sweet Taste Receptors Mediated ROS-NLRP3 Inflammasome Signaling Activation: Implications for Diabetic Nephropathy.
Zhou L, Huang W, Xu Y, Gao C, Zhang T, Guo M, Liu Y, Ding J, Qin L, Xu Z, Long Y, Xu Y.
J Diabetes Res. 2018 Feb 20;2018:7078214. doi: 10.1155/2018/7078214. eCollection 2018.

Cereal Fiber Ameliorates High-Fat/Cholesterol-Diet-Induced Atherosclerosis by Modulating the NLRP3 Inflammasome Pathway in ApoE-/- Mice.
Zhang R, Han S, Zhang Z, Zhang W, Yang J, Wan Z, Qin L.
J Agric Food Chem. 2018 May 16;66(19):4827-4834. doi: 10.1021/acs.jafc.8b00380. Epub 2018 May 7.

Cardioprotective Role of Colchicine Against Inflammatory Injury in a Rat Model of Acute Myocardial Infarction.
Bakhta O, Blanchard S, Guihot AL, Tamareille S, Mirebeau-Prunier D, Jeannin P, Prunier F.
J Cardiovasc Pharmacol Ther. 2018 Sep;23(5):446-455. doi: 10.1177/1074248418763611. Epub 2018 Apr 15.

Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke.
smael S, Zhao L, Nasoohi S, Ishrat T.
Sci Rep. 2018 Apr 13;8(1):5971. doi: 10.1038/s41598-018-24350-x.

Reply to: “Inhibitory effects of colchicine on inflammasomes”.
Martínez GJ, Celermajer DS, Patel S.
Atherosclerosis. 2018 Jun;273:155-156. doi: 10.1016/j.atherosclerosis.2018.03.042. Epub 2018 Mar 28. No abstract available. 

Methylene Blue Attenuates Diabetic Retinopathy by Inhibiting NLRP3 Inflammasome Activation in STZ-Induced Diabetic Rats.
Hao J, Zhang H, Yu J, Chen X, Yang L.
Ocul Immunol Inflamm. 2019;27(5):836-843. doi: 10.1080/09273948.2018.1450516. Epub 2018 Apr 2.

Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis, and Atherogenesis.
Westerterp M, Fotakis P, Ouimet M, Bochem AE, Zhang H, Molusky MM, Wang W, Abramowicz S, la Bastide-van Gemert S, Wang N, Welch CL, Reilly MP, Stroes ES, Moore KJ, Tall AR.
Circulation. 2018 Aug 28;138(9):898-912. doi: 10.1161/CIRCULATIONAHA.117.032636.

Cardiovascular diseasesNLRP3 inflammasome, and western dietary patterns.
Pavillard LE, Marín-Aguilar F, Bullon P, Cordero MD.
Pharmacol Res. 2018 May;131:44-50. doi: 10.1016/j.phrs.2018.03.018. Epub 2018 Mar 26. Review.

Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats.
Wang ML, Kang YM, Li XG, Su Q, Li HB, Liu KL, Fu LY, Saahene RO, Li Y, Tan H, Yu XJ.
J Neuroinflammation. 2018 Mar 24;15(1):95. doi: 10.1186/s12974-018-1131-7.

Mediterranean Diet, Glucose Homeostasis, and Inflammasome Genetic Variants: The CORDIOPREV Study.
Roncero-Ramos I, Rangel-Zuñiga OA, Lopez-Moreno J, Alcala-Diaz JF, Perez-Martinez P, Jimenez-Lucena R, Castaño JP, Roche HM, Delgado-Lista J, Ordovas JM, Camargo A, Lopez-Miranda J.
Mol Nutr Food Res. 2018 May;62(9):e1700960. doi: 10.1002/mnfr.201700960. Epub 2018 Apr 20.

Air pollution is associated with the development of atherosclerosis via the cooperation of CD36 and NLRP3 inflammasome in ApoE-/- mice.
Du X, Jiang S, Zeng X, Zhang J, Pan K, Zhou J, Xie Y, Kan H, Song W, Sun Q, Zhao J.
Toxicol Lett. 2018 Jun 15;290:123-132. doi: 10.1016/j.toxlet.2018.03.022. Epub 2018 Mar 20.

Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells.
Chen A, Chen Z, Xia Y, Lu D, Yang X, Sun A, Zou Y, Qian J, Ge J.
Biochem Biophys Res Commun. 2018 May 5;499(2):267-272. doi: 10.1016/j.bbrc.2018.03.142. Epub 2018 Mar 23.

Cardioprotective effect of rosuvastatin against isoproterenol-induced myocardial infarction injury in rats.
Yu Y, Jin L, Zhuang Y, Hu Y, Cang J, Guo K.
Int J Mol Med. 2018 Jun;41(6):3509-3516. doi: 10.3892/ijmm.2018.3572. Epub 2018 Mar 15.

Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK/Nrf2/HO-1 Pathway in Fructose-Fed Diabetic Rats.
Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S.
Cardiovasc Drugs Ther. 2018 Apr;32(2):147-163. doi: 10.1007/s10557-018-6780-3.

Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3Inflammasome.
Yin H, Guo Q, Li X, Tang T, Li C, Wang H, Sun Y, Feng Q, Ma C, Gao C, Yi F, Peng J.
J Immunol. 2018 Apr 15;200(8):2835-2846. doi: 10.4049/jimmunol.1701495. Epub 2018 Mar 16.

Indoxyl Sulfate Promotes Macrophage IL-1β Production by Activating Aryl Hydrocarbon Receptor/NF-κ/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated.
Wakamatsu T, Yamamoto S, Ito T, Sato Y, Matsuo K, Takahashi Y, Kaneko Y, Goto S, Kazama JJ, Gejyo F, Narita I.
Toxins (Basel). 2018 Mar 15;10(3). pii: E124. doi: 10.3390/toxins10030124.

Heart failure: Clonal haematopoiesis, IL-1β, and the NLRP3 inflammasome in HF.
Lim GB.
Nat Rev Cardiol. 2018 Mar 13;15(4):198. doi: 10.1038/nrcardio.2018.22. No abstract available. 

Differential mRNA expression of inflammasome genes NLRP1 and NLRP3 in abdominal aneurysmal and occlusive aortic disease.
Gonzalez-Hidalgo C, De Haro J, Bleda S, Cañibano C, Michel I, Acin F.
Ther Adv Cardiovasc Dis. 2018 Apr;12(4):123-129. doi: 10.1177/1753944717750338.

Inhibitory effects of colchicine on inflammasomes.
Hoss F, Latz E.
Atherosclerosis. 2018 Jun;273:153-154. doi: 10.1016/j.atherosclerosis.2018.02.026. Epub 2018 Mar 2. No abstract available. 

Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome.
Ding T, Wang S, Zhang X, Zai W, Fan J, Chen W, Bian Q, Luan J, Shen Y, Zhang Y, Ju D, Mei X.
Phytomedicine. 2018 Mar 1;41:45-53. doi: 10.1016/j.phymed.2018.01.026. Epub 2018 Jan 31.

RIP3-deficience attenuates potassium oxonate-induced hyperuricemia and kidney injury.
Wang K, Hu L, Chen JK.
Biomed Pharmacother. 2018 May;101:617-626. doi: 10.1016/j.biopha.2018.02.010. Epub 2018 Mar 22.

Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications.
Sharma A, Tate M, Mathew G, Vince JE, Ritchie RH, de Haan JB.
Front Physiol. 2018 Feb 20;9:114. doi: 10.3389/fphys.2018.00114. eCollection 2018. Review.

NLRP3 inflammasome inhibition ameliorates tubulointerstitial injury in the remnant kidney model.
Foresto-Neto O, Ávila VF, Arias SCA, Zambom FFF, Rempel LCT, Faustino VD, Machado FG, Malheiros DMAC, Abensur H, Camara NOS, Zatz R, Fujihara CK.
Lab Invest. 2018 Jun;98(6):773-782. doi: 10.1038/s41374-018-0029-4. Epub 2018 Mar 6.

Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation.
Tang TT, Lv LL, Pan MM, Wen Y, Wang B, Li ZL, Wu M, Wang FM, Crowley SD, Liu BC.
Cell Death Dis. 2018 Mar 2;9(3):351. doi: 10.1038/s41419-018-0378-3.

aureus Evades Macrophage Killing throughNLRP3-Dependent Effects on Mitochondrial Trafficking.
Cohen TS, Boland ML, Boland BB, Takahashi V, Tovchigrechko A, Lee Y, Wilde AD, Mazaitis MJ, Jones-Nelson O, Tkaczyk C, Raja R, Stover CK, Sellman BR.
Cell Rep. 2018 Feb 27;22(9):2431-2441. doi: 10.1016/j.celrep.2018.02.027.

mROS-TXNIP axis activates NLRP3 inflammasome to mediate renal injury during ischemic AKI.
Wen Y, Liu YR, Tang TT, Pan MM, Xu SC, Ma KL, Lv LL, Liu H, Liu BC.
Int J Biochem Cell Biol. 2018 May;98:43-53. doi: 10.1016/j.biocel.2018.02.015. Epub 2018 Mar 21.

Clonal Hematopoiesis Wages War on the Myocardium.
Swirski FK, Nahrendorf M.
J Am Coll Cardiol. 2018 Feb 27;71(8):887-889. doi: 10.1016/j.jacc.2017.12.038. No abstract available. 

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome.
Sano S, Oshima K, Wang Y, MacLauchlan S, Katanasaka Y, Sano M, Zuriaga MA, Yoshiyama M, Goukassian D, Cooper MA, Fuster JJ, Walsh K.
J Am Coll Cardiol. 2018 Feb 27;71(8):875-886. doi: 10.1016/j.jacc.2017.12.037.

Enhanced Expression of NLRP3 Inflammasome-Related Inflammation in Diabetic Retinopathy.
Chen H, Zhang X, Liao N, Mi L, Peng Y, Liu B, Zhang S, Wen F.
Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):978-985. doi: 10.1167/iovs.17-22816.

VEGF mitigates histone-induced pyroptosis in the remote liver injury associated with renal allograft ischemia-reperfusion injury in rats.
Zhao H, Huang H, Alam A, Chen Q, Suen KC, Cui J, Sun Q, Ologunde R, Zhang W, Lian Q, Ma D.
Am J Transplant. 2018 Aug;18(8):1890-1903. doi: 10.1111/ajt.14699. Epub 2018 Mar 23.

The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy.
Chaurasia SS, Lim RR, Parikh BH, Wey YS, Tun BB, Wong TY, Luu CD, Agrawal R, Ghosh A, Mortellaro A, Rackoczy E, Mohan RR, Barathi VA.
Sci Rep. 2018 Feb 12;8(1):2847. doi: 10.1038/s41598-018-21198-z.

Mesenchymal stromal cells inhibit NLRP3 inflammasome activation in a model of Coxsackievirus B3-induced inflammatory cardiomyopathy.
Miteva K, Pappritz K, Sosnowski M, El-Shafeey M, Müller I, Dong F, Savvatis K, Ringe J, Tschöpe C, Van Linthout S.
Sci Rep. 2018 Feb 12;8(1):2820. doi: 10.1038/s41598-018-20686-6.

Role of Brain Neuroinflammatory Factors on Hypertension in the Spontaneously Hypertensive Rat.
Avolio E, Pasqua T, Di Vito A, Fazzari G, Cardillo G, Alò R, Cerra MC, Barni T, Angelone T, Canonaco M.
Neuroscience. 2018 Apr 1;375:158-168. doi: 10.1016/j.neuroscience.2018.01.067. Epub 2018 Feb 9.

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.
Wu X, Zhang H, Qi W, Zhang Y, Li J, Li Z, Lin Y, Bai X, Liu X, Chen X, Yang H, Xu C, Zhang Y, Yang B.
Cell Death Dis. 2018 Feb 7;9(2):171. doi: 10.1038/s41419-017-0257-3.

Metabolic/inflammatory/vascular comorbidity in psychiatric disorders; soluble epoxide hydrolase (sEH) as a possible new target.
Swardfager W, Hennebelle M, Yu D, Hammock BD, Levitt AJ, Hashimoto K, Taha AY.
Neurosci Biobehav Rev. 2018 Apr;87:56-66. doi: 10.1016/j.neubiorev.2018.01.010. Epub 2018 Feb 2. Review.

 LncRNA MALAT1 sponges miR-133 to promote NLRP3 inflammasome expression in ischemia-reperfusion injured heart.
Yu SY, Dong B, Tang L, Zhou SH.
Int J Cardiol. 2018 Mar 1;254:50. doi: 10.1016/j.ijcard.2017.10.071. Epub 2018 Jan 28. No abstract available. 

Endothelial GPR124 Exaggerates the Pathogenesis of Atherosclerosis by Activating Inflammation.
Gong DM, Zhang YL, Chen DY, Hong LJ, Han F, Liu QB, Jiang JJ, Lu YM.
Cell Physiol Biochem. 2018;45(2):547-557. doi: 10.1159/000487032. Epub 2018 Jan 25.

IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats.
Chen D, Dixon BJ, Doycheva DM, Li B, Zhang Y, Hu Q, He Y, Guo Z, Nowrangi D, Flores J, Filippov V, Zhang JH, Tang J.
J Neuroinflammation. 2018 Feb 2;15(1):32. doi: 10.1186/s12974-018-1077-9.

Platelets at the crossroads of thrombosis, inflammation and haemolysis.
Vogel S, Thein SL.
Br J Haematol. 2018 Mar;180(5):761-767. doi: 10.1111/bjh.15117. Epub 2018 Jan 30.

The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation.
Martínez GJ, Celermajer DS, Patel S.
Atherosclerosis. 2018 Feb;269:262-271. doi: 10.1016/j.atherosclerosis.2017.12.027. Epub 2017 Dec 25. Review. Erratum in: Atherosclerosis. 2018 Jun;273:157

Fibronectin type III domain containing 5 attenuates NLRP3 inflammasome activation and phenotypic transformation of adventitial fibroblasts in spontaneously hypertensive rats.
Ling L, Chen D, Tong Y, Zang YH, Ren XS, Zhou H, Qi XH, Chen Q, Li YH, Kang YM, Zhu GQ.
J Hypertens. 2018 May;36(5):1104-1114. doi: 10.1097/HJH.0000000000001654.

Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice.
J Neuroinflammation. 2018 Jan 4;15(1):2. doi: 10.1186/s12974-017-1039-7.

Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat.
Zhou K, Enkhjargal B, Xie Z, Sun C, Wu L, Malaguit J, Chen S, Tang J, Zhang J, Zhang JH.
Stroke. 2018 Jan;49(1):175-183. doi: 10.1161/STROKEAHA.117.018593.

Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation.
Liu Q, Zhang F, Zhang X, Cheng R, Ma JX, Yi J, Li J.
Mol Cell Biochem. 2018 Aug;445(1-2):105-115. doi: 10.1007/s11010-017-3256-x. Epub 2017 Dec 21.

NLRP3 Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular Remodeling.
Ren XS, Tong Y, Ling L, Chen D, Sun HJ, Zhou H, Qi XH, Chen Q, Li YH, Kang YM, Zhu GQ.
Cell Physiol Biochem. 2017;44(6):2269-2280. doi: 10.1159/000486061. Epub 2017 Dec 14.

Suppression of NLRP3 attenuates hemorrhagic transformation after delayed rtPA treatment in thromboembolic stroke rats: Involvement of neutrophil recruitment.
Guo Z, Yu S, Chen X, Zheng P, Hu T, Duan Z, Liu X, Liu Q, Ye R, Zhu W, Liu X.
Brain Res Bull. 2018 Mar;137:229-240. doi: 10.1016/j.brainresbull.2017.12.009. Epub 2017 Dec 16.

The protective effect of umbelliferone ameliorates myocardial injury following ischemia‑reperfusion in the rat through suppression NLRP3 inflammasome and upregulating the PPAR-γ.
Luo H, Fan Z, Xiang D, Jiang Z, Zhang W, Gao L, Feng C.
Mol Med Rep. 2018 Feb;17(2):3404-3410. doi: 10.3892/mmr.2017.8208. Epub 2017 Dec 6.

NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction.
Pavillard LE, Cañadas-Lozano D, Alcocer-Gómez E, Marín-Aguilar F, Pereira S, Robertson AAB, Muntané J, Ryffel B, Cooper MA, Quiles JL, Bullón P, Ruiz-Cabello J, Cordero MD.
Oncotarget. 2017 Sep 8;8(59):99740-99756. doi: 10.18632/oncotarget.20763. eCollection 2017 Nov 21

Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases.
Liu D, Zeng X, Li X, Mehta JL, Wang X.
Basic Res Cardiol. 2017 Dec 9;113(1):5. doi: 10.1007/s00395-017-0663-9. Print 2018 Jan 8. Review.

Selective NLRP3 (Pyrin Domain-Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage.
Ren H, Kong Y, Liu Z, Zang D, Yang X, Wood K, Li M, Liu Q.
Stroke. 2018 Jan;49(1):184-192. doi: 10.1161/STROKEAHA.117.018904. Epub 2017 Dec 6.

NACHT, LRR and PYD domains-containing protein 3 inflammasome is activated and inhibited by berberine via toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-κB pathway, in phorbol 12-myristate 13-acetate-induced macrophages.
Huang Z, Ye B, Han J, Kong F, Shan P, Lu Z, Huang Z, Huang W.
Mol Med Rep. 2018 Feb;17(2):2673-2680. doi: 10.3892/mmr.2017.8189. Epub 2017 Nov 29.

Protective effect of baicalin against severe burn‑induced remote acute lung injury in rats.
Bai C, Li T, Sun Q, Xin Q, Xu T, Yu J, Wang Y, Wei L.
Mol Med Rep. 2018 Feb;17(2):2689-2694. doi: 10.3892/mmr.2017.8120. Epub 2017 Nov 20.

Intermedin1-53 Protects Cardiac Fibroblasts by Inhibiting NLRP3 Inflammasome Activation During Sepsis.
Wu D, Shi L, Li P, Ni X, Zhang J, Zhu Q, Qi Y, Wang B.
Inflammation. 2018 Mar;41(2):505-514. doi: 10.1007/s10753-017-0706-2.

Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation.
Gregersen I, Sandanger Ø, Askevold ET, Sagen EL, Yang K, Holm S, Pedersen TM, Skjelland M, Krohg-Sørensen K, Hansen TV, Dahl TB, Otterdal K, Espevik T, Aukrust P, Yndestad A, Halvorsen B.
PLoS One. 2017 Nov 27;12(11):e0188387. doi: 10.1371/journal.pone.0188387. eCollection 2017.

TLR4 and NLRP3 Caspase 1- IL-1β- Axis are not Involved in Colon Ascendens Stent Peritonitis (Casp)-Associated Heart Disease.
Alarcón MML, Ruocco JF, Ferreira F, Paula-Neto HA, Sepúlveda M, Petroff MV, Carvalho AB, Ramos IP, Branda HJ, Paiva CN, Medei E.
Shock. 2017 Nov 15. doi: 10.1097/SHK.0000000000001059. [Epub ahead of print]

Transplantation of Human Umbilical Cord Blood Mononuclear Cells Attenuated Ischemic Injury in MCAO Rats via Inhibition of NF-κB and NLRP3 Inflammasome.
Liu L, Cen J, Man Y, Li J, Zhang D, Wang F, Li J, Ma J, Wang X, Ji B.
Neuroscience. 2018 Jan 15;369:314-324. doi: 10.1016/j.neuroscience.2017.11.027. Epub 2017 Nov 24.

The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP release.
Mugisho OO, Green CR, Kho DT, Zhang J, Graham ES, Acosta ML, Rupenthal ID.
Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):385-393. doi: 10.1016/j.bbagen.2017.11.015. Epub 2017 Nov 21.

Infectious Agents in Atherosclerotic Cardiovascular Diseases through Oxidative Stress.
Di Pietro M, Filardo S, Falasca F, Turriziani O, Sessa R.
Int J Mol Sci. 2017 Nov 18;18(11). pii: E2459. doi: 10.3390/ijms18112459. Review.

Study of the NLRP3 inflammasome component genes and downstream cytokines in patients with type 2 diabetes mellitus with carotid atherosclerosis.
Lee J, Wan J, Lee L, Peng C, Xie H, Lee C.
Lipids Health Dis. 2017 Nov 18;16(1):217. doi: 10.1186/s12944-017-0595-2.

AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging.
Cordero MD, Williams MR, Ryffel B.
Trends Endocrinol Metab. 2018 Jan;29(1):8-17. doi: 10.1016/j.tem.2017.10.009. Epub 2017 Nov 14. Review.

Effects of chronically increased VEGF-A on the aging heart.
Marneros AG.
FASEB J. 2018 Mar;32(3):1550-1565. doi: 10.1096/fj.201700761RR. Epub 2018 Jan 3.

The NLRP3 inflammasome in acute myocardial infarction.
Toldo S, Abbate A.
Nat Rev Cardiol. 2018 Apr;15(4):203-214. doi: 10.1038/nrcardio.2017.161. Epub 2017 Nov 16. Review.

Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction.
Boini KM, Hussain T, Li PL, Koka S.
Cell Physiol Biochem. 2017;44(1):152-162. doi: 10.1159/000484623. Epub 2017 Nov 6.

NLRP3 inflammasome pathways in atherosclerosis.
Baldrighi M, Mallat Z, Li X.
Atherosclerosis. 2017 Dec;267:127-138. doi: 10.1016/j.atherosclerosis.2017.10.027. Epub 2017 Oct 22. Review.

Acupuncture inhibits TXNIP-associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats.
Du SQ, Wang XR, Zhu W, Ye Y, Yang JW, Ma SM, Ji CS, Liu CZ.
CNS Neurosci Ther. 2018 Jan;24(1):39-46. doi: 10.1111/cns.12773. Epub 2017 Nov 6.

BCL6 attenuates renal inflammation via negative regulation of NLRP3 transcription.
Chen D, Xiong XQ, Zang YH, Tong Y, Zhou B, Chen Q, Li YH, Gao XY, Kang YM, Zhu GQ.
Cell Death Dis. 2017 Oct 26;8(10):e3156. doi: 10.1038/cddis.2017.567.

shRNA interference of NLRP3 inflammasome alleviate ischemia reperfusion-induced myocardial damage through autophagy activation.
Meng Z, Song MY, Li CF, Zhao JQ.
Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):728-735. doi: 10.1016/j.bbrc.2017.10.111. Epub 2017 Oct 22.

NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats.
Qiu Z, Lei S, Zhao B, Wu Y, Su W, Liu M, Meng Q, Zhou B, Leng Y, Xia ZY.
Oxid Med Cell Longev. 2017;2017:9743280. doi: 10.1155/2017/9743280. Epub 2017 Sep 14.

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis.
Zhang Y, Liu X, Bai X, Lin Y, Li Z, Fu J, Li M, Zhao T, Yang H, Xu R, Li J, Ju J, Cai B, Xu C, Yang B.
Pineal Res. 2018 Mar;64(2). doi: 10.1111/jpi.12449. Epub 2017 Dec 20.

H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation.
Zhang X, Pan L, Yang K, Fu Y, Liu Y, Chi J, Zhang X, Hong S, Ma X, Yin X.
Cell Physiol Biochem. 2017;43(4):1311-1324. doi: 10.1159/000481843. Epub 2017 Oct 9.

Protective Effects of Microrna-22 Against Endothelial Cell Injury by Targeting NLRP3 Through Suppression of the Inflammasome Signaling Pathway in a Rat Model of Coronary Heart Disease.
Huang WQ, Wei P, Lin RQ, Huang F.
Cell Physiol Biochem. 2017;43(4):1346-1358. doi: 10.1159/000481846. Epub 2017 Oct 9.

The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation.
Gan W, Ren J, Li T, Lv S, Li C, Liu Z, Yang M.
Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):1-10. doi: 10.1016/j.bbadis.2017.10.001. Epub 2017 Oct 3.

NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension.
Sun HJ, Ren XS, Xiong XQ, Chen YZ, Zhao MX, Wang JJ, Zhou YB, Han Y, Chen Q, Li YH, Kang YM, Zhu GQ.
Cell Death Dis. 2017 Oct 5;8(10):e3074. doi: 10.1038/cddis.2017.470.

Neuroprotective Effects of Luteolin Against Spinal Cord Ischemia-Reperfusion Injury by Attenuation of Oxidative Stress, Inflammation, and Apoptosis.
Fu J, Sun H, Zhang Y, Xu W, Wang C, Fang Y, Zhao J.
J Med Food. 2018 Jan;21(1):13-20. doi: 10.1089/jmf.2017.4021. Epub 2017 Oct 4.

Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway.
Peng J, Deng X, Huang W, Yu JH, Wang JX, Wang JP, Yang SB, Liu X, Wang L, Zhang Y, Zhou XY, Yang H, He YZ, Xu FY.
Mol Immunol. 2017 Nov;91:185-194. doi: 10.1016/j.molimm.2017.09.014. Epub 2017 Sep 30.

Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion.
Xu X, Zhang L, Ye X, Hao Q, Zhang T, Cui G, Yu M.
Inflamm Res. 2018 Jan;67(1):57-65. doi: 10.1007/s00011-017-1095-6. Epub 2017 Sep 27.

Oleanolic acid alleviates diabetic rat carotid artery injury through the inhibition of NLRP3inflammasome signaling pathways.
An Q, Hu Q, Wang B, Cui W, Wu F, Ding Y.
Mol Med Rep. 2017 Dec;16(6):8413-8419. doi: 10.3892/mmr.2017.7594. Epub 2017 Sep 25.

Inflammation: Activated protein C inhibits inflammasome activation in IRI.
Carney EF.
Nat Rev Nephrol. 2017 Nov;13(11):662. doi: 10.1038/nrneph.2017.139. Epub 2017 Sep 25. No abstract available. 

Activating α7 nicotinic acetylcholine receptor inhibits NLRP3 inflammasome through regulation of β-arrestin-1.
Ke P, Shao BZ, Xu ZQ, Chen XW, Wei W, Liu C.
CNS Neurosci Ther. 2017 Nov;23(11):875-884. doi: 10.1111/cns.12758. Epub 2017 Sep 21.

Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy.
Garibotto G, Carta A, Picciotto D, Viazzi F, Verzola D.
J Nephrol. 2017 Dec;30(6):719-727. doi: 10.1007/s40620-017-0432-8. Epub 2017 Sep 20. Review.

Nrf2/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation.
Wang Z, Guo S, Wang J, Shen Y, Zhang J, Wu Q.
Sci Rep. 2017 Sep 19;7(1):11883. doi: 10.1038/s41598-017-12160-6.

NOD2 (Nucleotide-Binding Oligomerization Domain 2) Is a Major Pathogenic Mediator of Coxsackievirus B3-Induced Myocarditis.
Tschöpe C, Müller I, Xia Y, Savvatis K, Pappritz K, Pinkert S, Lassner D, Heimesaat MM, Spillmann F, Miteva K, Bereswill S, Schultheiss HP, Fechner H, Pieske B, Kühl U, Van Linthout S.
Circ Heart Fail. 2017 Sep;10(9). pii: e003870. doi: 10.1161/CIRCHEARTFAILURE.117.003870.

Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats.
Li JR, Xu HZ, Nie S, Peng YC, Fan LF, Wang ZJ, Wu C, Yan F, Chen JY, Gu C, Wang C, Chen JS, Wang L, Chen G.
J Neuroinflammation. 2017 Sep 13;14(1):186. doi: 10.1186/s12974-017-0959-6.

Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome.
Zhang S, Jiang L, Che F, Lu Y, Xie Z, Wang H.
Biochem Biophys Res Commun. 2017 Nov 4;493(1):821-826. doi: 10.1016/j.bbrc.2017.08.062. Epub 2017 Sep 6.

Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition.
Nazir S, Gadi I, Al-Dabet MM, Elwakiel A, Kohli S, Ghosh S, Manoharan J, Ranjan S, Bock F, Braun-Dullaeus RC, Esmon CT, Huber TB, Camerer E, Dockendorff C, Griffin JH, Isermann B, Shahzad K.
Blood. 2017 Dec 14;130(24):2664-2677. doi: 10.1182/blood-2017-05-782102. Epub 2017 Sep 7.

Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway.
Chen ML, Zhu XH, Ran L, Lang HD, Yi L, Mi MT.
J Am Heart Assoc. 2017 Sep 4;6(9). pii: e006347. doi: 10.1161/JAHA.117.006347. Erratum in: J Am Heart Assoc. 2017 Nov 8;6(11):

The NLPR3 inflammasome and obesity-related kidney disease.
Ke B, Shen W, Fang X, Wu Q.
J Cell Mol Med. 2018 Jan;22(1):16-24. doi: 10.1111/jcmm.13333. Epub 2017 Aug 31. Review

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial.
Ridker PM, MacFadyen JG, Thuren T, Everett BM, Libby P, Glynn RJ; CANTOS Trial Group.
Lancet. 2017 Oct 21;390(10105):1833-1842. doi: 10.1016/S0140-6736(17)32247-X. Epub 2017 Aug 27.

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury.
Hou Y, Wang Y, He Q, Li L, Xie H, Zhao Y, Zhao J.
Behav Brain Res. 2018 Jan 15;336:32-39. doi: 10.1016/j.bbr.2017.06.027. Epub 2017 Aug 26.

Calmodulin inhibitor ameliorates cognitive dysfunction via inhibiting nitrosative stress and NLRP3signaling in mice with bilateral carotid artery stenosis.
Wang R, Yin YX, Mahmood Q, Wang XJ, Gao YP, Gou GJ, Ahmed MM, Kohji F, Du YZ, Han F.
CNS Neurosci Ther. 2017 Oct;23(10):818-826. doi: 10.1111/cns.12726. Epub 2017 Aug 28.

[NOD-like receptor pyrin domain containing 3 inflammasome and myocardial ischemia-reperfusion injury].
Dong B, Zhou S, Yu S, Tang L.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Jul 28;42(7):848-853. doi: 10.11817/j.issn.1672-7347.2017.07.018. Chinese. 

Endogenous hydrogen sulphide attenuates NLRP3 inflammasome-mediated neuroinflammation by suppressing the P2X7 receptor after intracerebral haemorrhage in rats.
Zhao H, Pan P, Yang Y, Ge H, Chen W, Qu J, Shi J, Cui G, Liu X, Feng H, Chen Y.
J Neuroinflammation. 2017 Aug 18;14(1):163. doi: 10.1186/s12974-017-0940-4.

Mutational profile of rare variants in inflammasome-related genes in Behçet disease: A Next Generation Sequencing approach.
Burillo-Sanz S, Montes-Cano MA, García-Lozano JR, Ortiz-Fernández L, Ortego-Centeno N, García-Hernández FJ, Espinosa G, Graña-Gil G, Sánchez-Bursón J, Rosa Juliá M, Solans R, Blanco R, Barnosi-Marín AC, Gómez De la Torre R, Fanlo P, Rodríguez-Carballeira M, Rodríguez-Rodríguez L, Camps T, Castañeda S, Alegre-Sancho JJ, Martín J, González-Escribano MF.
Sci Rep. 2017 Aug 16;7(1):8453. doi: 10.1038/s41598-017-09164-7.

Inhibition of TLR4 alleviates the inflammation and apoptosis of retinal ganglion cells in high glucose.
Hu L, Yang H, Ai M, Jiang S.
Graefes Arch Clin Exp Ophthalmol. 2017 Nov;255(11):2199-2210. doi: 10.1007/s00417-017-3772-0. Epub 2017 Aug 14.

Cholesterol crystal embolization following plaque rupture: a systemic disease with unusual features.
Ghanem F, Vodnala D, K Kalavakunta J, Durga S, Thormeier N, Subramaniyam P, Abela S, S Abela G.
J Biomed Res. 2017 Jan 19;31(2):82-94. doi: 10.7555/JBR.31.20160100.

NLRP3 Inflammasome as a Molecular Marker in Diabetic Cardiomyopathy.
Luo B, Huang F, Liu Y, Liang Y, Wei Z, Ke H, Zeng Z, Huang W, He Y.
Front Physiol. 2017 Jul 25;8:519. doi: 10.3389/fphys.2017.00519. eCollection 2017. Review.

Ghrelin protects the heart against ischemia/reperfusion injury via inhibition of TLR4/NLRP3inflammasome pathway.
Wang Q, Lin P, Li P, Feng L, Ren Q, Xie X, Xu J.
Life Sci. 2017 Oct 1;186:50-58. doi: 10.1016/j.lfs.2017.08.004. Epub 2017 Aug 4.

T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders.
Rani J, Mittal I, Pramanik A, Singh N, Dube N, Sharma S, Puniya BL, Raghunandanan MV, Mobeen A, Ramachandran S.
Sci Rep. 2017 Jul 31;7(1):6892. doi: 10.1038/s41598-017-07238-0.

The NLRP3 Inflammasome: An Important Driver of Neuroinflammation in Hemorrhagic Stroke.
Yang SJ, Shao GF, Chen JL, Gong J.
Cell Mol Neurobiol. 2018 Apr;38(3):595-603. doi: 10.1007/s10571-017-0526-9. Epub 2017 Jul 27. Review.

Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction.
Zhang Y, Lv X, Hu Z, Ye X, Zheng X, Ding Y, Xie P, Liu Q.
Cell Death Dis. 2017 Jul 20;8(7):e2941. doi: 10.1038/cddis.2017.308.

Nutritional modulation of metabolic inflammation.
Kirwan AM, Lenighan YM, O’Reilly ME, McGillicuddy FC, Roche HM.
Biochem Soc Trans. 2017 Aug 15;45(4):979-985. doi: 10.1042/BST20160465. Epub 2017 Jul 14. Review.

Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction.
He Q, Li Z, Wang Y, Hou Y, Li L, Zhao J.
Int Immunopharmacol. 2017 Sep;50:208-215. doi: 10.1016/j.intimp.2017.06.029. Epub 2017 Jul 3.

Can Serum Uric Acid Lowering Therapy Contribute to the Prevention or Treatment of Nonalcoholic Fatty Liver Disease?
Paschos P, Athyros VG, Tsimperidis A, Katsoula A, Grammatikos N, Giouleme O.
Curr Vasc Pharmacol. 2018;16(3):269-275. doi: 10.2174/1570161115666170621082237. Review.

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress.
Dinh QN, Drummond GR, Kemp-Harper BK, Diep H, De Silva TM, Kim HA, Vinh A, Robertson AAB, Cooper MA, Mansell A, Chrissobolis S, Sobey CG.
Aging (Albany NY). 2017 Jun 28;9(6):1595-1606. doi: 10.18632/aging.101255.

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism.
Li X, Thome S, Ma X, Amrute-Nayak M, Finigan A, Kitt L, Masters L, James JR, Shi Y, Meng G, Mallat Z.
Nat Commun. 2017 Jun 28;8:15986. doi: 10.1038/ncomms15986.

Silymarin prevents NLRP3 inflammasome activation and protects against intracerebral hemorrhage.
Yuan R, Fan H, Cheng S, Gao W, Xu X, Lv S, Ye M, Wu M, Zhu X, Zhang Y.
Biomed Pharmacother. 2017 Sep;93:308-315. doi: 10.1016/j.biopha.2017.06.018. Epub 2017 Jun 24.

The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice.
Landlinger C, Pouwer MG, Juno C, van der Hoorn JWA, Pieterman EJ, Jukema JW, Staffler G, Princen HMG, Galabova G.
Eur Heart J. 2017 Aug 21;38(32):2499-2507. doi: 10.1093/eurheartj/ehx260.

Bone mesenchymal stem cells ameliorate ischemia/reperfusion-induced damage in renal epithelial cells via microRNA-223.
Yuan X, Wang X, Chen C, Zhou J, Han M.
Stem Cell Res Ther. 2017 Jun 15;8(1):146. doi: 10.1186/s13287-017-0599-x.

Expression of TLR2, NOD1, and NOD2 and the NLRP3 Inflammasome in Renal Tubular Epithelial Cells of Male versus Female Mice.
DeWolf SE, Shigeoka AA, Scheinok A, Kasimsetty SG, Welch AK, McKay DB.
Nephron. 2017;137(1):68-76. doi: 10.1159/000456016. Epub 2017 Jun 15.

Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway.
J Neuroinflammation. 2017 Jun 13;14(1):119. doi: 10.1186/s12974-017-0895-5.

Innate And Adaptive Immunity are Progressively Activated in Parallel with Renal Injury in the 5/6 Renal Ablation Model.
Fanelli C, Arias SCA, Machado FG, Okuma JK, Malheiros DMAC, Azevedo H, Moreira-Filho CA, Camara NOS, Fujihara CK, Zatz R.
Sci Rep. 2017 Jun 9;7(1):3192. doi: 10.1038/s41598-017-02915-6.

[The Protective Effect of Tanshinone IIA on Oxygen-glucose Deprivation and Reperfusion Injury of MicrogliaThrough the NLRP3 Inflammatory Signaling Pathway].
Cai L, Yi XB, Yuan LB, Gong G.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2016 Sep;47(5):660-664. Chinese. 

NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report.
van der Heijden T, Kritikou E, Venema W, van Duijn J, van Santbrink PJ, Slütter B, Foks AC, Bot I, Kuiper J.
Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1457-1461. doi: 10.1161/ATVBAHA.117.309575. Epub 2017 Jun 8.

RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage.
Zhou K, Shi L, Wang Z, Zhou J, Manaenko A, Reis C, Chen S, Zhang J.
Exp Neurol. 2017 Sep;295:116-124. doi: 10.1016/j.expneurol.2017.06.003. Epub 2017 Jun 2.

Inflammasomes and IL-1 biology in the pathogenesis of allograft dysfunction.
Weigt SS, Palchevskiy V, Belperio JA.
J Clin Invest. 2017 Jun 1;127(6):2022-2029. doi: 10.1172/JCI93537. Epub 2017 Jun 1. Review.

IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult.
Xiao H, Li H, Wang JJ, Zhang JS, Shen J, An XB, Zhang CC, Wu JM, Song Y, Wang XY, Yu HY, Deng XN, Li ZJ, Xu M, Lu ZZ, Du J, Gao W, Zhang AH, Feng Y, Zhang YY.
Eur Heart J. 2018 Jan 1;39(1):60-69. doi: 10.1093/eurheartj/ehx261.

Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation.
Cao S, Shrestha S, Li J, Yu X, Chen J, Yan F, Ying G, Gu C, Wang L, Chen G.
Sci Rep. 2017 May 25;7(1):2417. doi: 10.1038/s41598-017-02679-z.

Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNFα in Vascular Endothelial Cells through a PXR-Dependent Mechanism.
Wang S, Xie X, Lei T, Zhang K, Lai B, Zhang Z, Guan Y, Mao G, Xiao L, Wang N.
Mol Pharmacol. 2017 Sep;92(3):256-264. doi: 10.1124/mol.116.108100. Epub 2017 May 25.

The protective effect of Luteolin on myocardial ischemia/reperfusion (I/R) injury through TLR4/NF-κB/NLRP3 inflammasome pathway.
Zhang X, Du Q, Yang Y, Wang J, Dou S, Liu C, Duan J.
Biomed Pharmacother. 2017 Jul;91:1042-1052. doi: 10.1016/j.biopha.2017.05.033. Epub 2017 May 15.

Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.
Westerterp M, Gautier EL, Ganda A, Molusky MM, Wang W, Fotakis P, Wang N, Randolph GJ, D’Agati VD, Yvan-Charvet L, Tall AR.
Cell Metab. 2017 Jun 6;25(6):1294-1304.e6. doi: 10.1016/j.cmet.2017.04.005. Epub 2017 May 4.

Human Plasma Thioredoxin-80 Increases With Age and in ApoE-/- Mice Induces Inflammation, Angiogenesis, and Atherosclerosis.
Couchie D, Vaisman B, Abderrazak A, Mahmood DFD, Hamza MM, Canesi F, Diderot V, El Hadri K, Nègre-Salvayre A, Le Page A, Fulop T, Remaley AT, Rouis M.
Circulation. 2017 Aug 1;136(5):464-475. doi: 10.1161/CIRCULATIONAHA.117.027612. Epub 2017 May 4.

P2X7 receptor inhibition attenuated sympathetic nerve sprouting after myocardial infarction via the NLRP3/IL-1β pathway.
Yin J, Wang Y, Hu H, Li X, Xue M, Cheng W, Wang Y, Li X, Yang N, Shi Y, Yan S.
J Cell Mol Med. 2017 Nov;21(11):2695-2710. doi: 10.1111/jcmm.13185. Epub 2017 May 4.

Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway.
Yin Y, Chen F, Wang W, Wang H, Zhang X.
Mol Vis. 2017 Apr 14;23:242-250. eCollection 2017.

Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway.
Yu C, Liu Y, Sun L, Wang D, Wang Y, Zhao S, Dai H, Zhao J, Zhang S, Li M, Han Y, Lu S, Dong X, Liu G, Yu S, Li Y.
Oncotarget. 2017 Jun 6;8(23):37705-37716. doi: 10.18632/oncotarget.17144.

The NLRP3 and CASP1 gene polymorphisms are associated with developing of acute coronary syndrome: a case-control study.
Gonzalez-Pacheco H, Vargas-Alarcon G, Angeles-Martinez J, Martinez-Sanchez C, Perez-Mendez O, Herrera-Maya G, Martinez-Rios MA, Peña-Duque MA, Posadas-Romero C, Fragoso JM.
Immunol Res. 2017 Aug;65(4):862-868. doi: 10.1007/s12026-017-8924-0.

SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor.
Ye Y, Bajaj M, Yang HC, Perez-Polo JR, Birnbaum Y.
Cardiovasc Drugs Ther. 2017 Apr;31(2):119-132. doi: 10.1007/s10557-017-6725-2.

Stress-Induced NLRP3 Inflammasome in Human Diseases.
Alcocer-Gómez E, Castejón-Vega B, Cordero MD.
Adv Protein Chem Struct Biol. 2017;108:127-162. doi: 10.1016/bs.apcsb.2017.02.002. Epub 2017 Mar 27. Review.

Colchicine Improves Survival, Left Ventricular Remodeling, and Chronic Cardiac Function After Acute Myocardial Infarction.
Fujisue K, Sugamura K, Kurokawa H, Matsubara J, Ishii M, Izumiya Y, Kaikita K, Sugiyama S.
Circ J. 2017 Jul 25;81(8):1174-1182. doi: 10.1253/circj.CJ-16-0949. Epub 2017 Apr 18.

Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia.
Gupta N, Sahu A, Prabhakar A, Chatterjee T, Tyagi T, Kumari B, Khan N, Nair V, Bajaj N, Sharma M, Ashraf MZ.
Proc Natl Acad Sci U S A. 2017 May 2;114(18):4763-4768. doi: 10.1073/pnas.1620458114. Epub 2017 Apr 18.

Particulate matter air pollution from the city of Quito, Ecuador, activates inflammatory signaling pathways in vitro.
Cevallos VM, Díaz V, Sirois CM.
Innate Immun. 2017 May;23(4):392-400. doi: 10.1177/1753425917699864. Epub 2017 Mar 21.

Metaflammation: Tissue-Specific Alterations of the NLRP3 Inflammasome Platform in Metabolic Syndrome.
Mastrocola R, Aragno M, Alloatti G, Collino M, Penna C, Pagliaro P.
Curr Med Chem. 2018;25(11):1294-1310. doi: 10.2174/0929867324666170407123522. Review.

Cordycepin confers neuroprotection in mice models of intracerebral hemorrhage via suppressing NLRP3 inflammasome activation.
Cheng Y, Wei Y, Yang W, Song Y, Shang H, Cai Y, Wu Z, Zhao W.
Metab Brain Dis. 2017 Aug;32(4):1133-1145. doi: 10.1007/s11011-017-0003-7. Epub 2017 Apr 11.

Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice.
Wang R, Wang Y, Mu N, Lou X, Li W, Chen Y, Fan D, Tan H.
Lab Invest. 2017 Aug;97(8):922-934. doi: 10.1038/labinvest.2017.30. Epub 2017 Apr 10.

NLRP3 inflammasome induced liver graft injury through activation of telomere-independent RAP1/KC axis.
Liu H, Lo CM, Yeung OWH, Li CX, Liu XB, Qi X, Ng KTP, Liu J, Ma YY, Lam YF, Lian Q, Chan SC, Man K.
J Pathol. 2017 Jul;242(3):284-296. doi: 10.1002/path.4901. Epub 2017 May 15.

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis.
Hoseini Z, Sepahvand F, Rashidi B, Sahebkar A, Masoudifar A, Mirzaei H.
J Cell Physiol. 2018 Mar;233(3):2116-2132. doi: 10.1002/jcp.25930. Epub 2017 May 23. Review.

MicroRNA-9 Inhibits NLRP3 Inflammasome Activation in Human Atherosclerosis Inflammation Cell Models through the JAK1/STAT Signaling Pathway.
Wang Y, Han Z, Fan Y, Zhang J, Chen K, Gao L, Zeng H, Cao J, Wang C.
Cell Physiol Biochem. 2017;41(4):1555-1571. doi: 10.1159/000470822. Epub 2017 Mar 27.

A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte.
Mezzasoma L, Antognelli C, Talesa VN.
Mediators Inflamm. 2017;2017:5858315. doi: 10.1155/2017/5858315. Epub 2017 Feb 26.

Pre-conditioning with tanshinone IIA attenuates the ischemia/reperfusion injury caused by liver grafts via regulation of HMGB1 in rat Kupffer cells.
Li X, Wu Y, Zhang W, Gong J, Cheng Y.
Biomed Pharmacother. 2017 May;89:1392-1400. doi: 10.1016/j.biopha.2017.03.022. Epub 2017 Mar 19.

The TIR/BB-loop mimetic AS-1 prevents non-alcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3-ASC inflammasome activation.
Wang X, Gao Y, Song J, Tang C, Wang M, Que L, Liu L, Zhu G, Chen Q, Yao Y, Xu Y, Li J, Li Y.
Br J Pharmacol. 2017 Jun;174(12):1841-1856. doi: 10.1111/bph.13786. Epub 2017 Apr 26.

Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse.
Ye X, Shen T, Hu J, Zhang L, Zhang Y, Bao L, Cui C, Jin G, Zan K, Zhang Z, Yang X, Shi H, Zu J, Yu M, Song C, Wang Y, Qi S, Cui G.
Exp Neurol. 2017 Jun;292:46-55. doi: 10.1016/j.expneurol.2017.03.002. Epub 2017 Mar 6.

NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy.
Loukovaara S, Piippo N, Kinnunen K, Hytti M, Kaarniranta K, Kauppinen A.
Acta Ophthalmol. 2017 Dec;95(8):803-808. doi: 10.1111/aos.13427. Epub 2017 Mar 8.

Placental hemostasis and sterile inflammation: New insights into gestational vascular disease.
Kohli S, Isermann B.
Thromb Res. 2017 Mar;151 Suppl 1:S30-S33. doi: 10.1016/S0049-3848(17)30063-4. Review.

Cholesterol crystals enhance TLR2- and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis.
Køllgaard T, Enevold C, Bendtzen K, Hansen PR, Givskov M, Holmstrup P, Nielsen CH.
PLoS One. 2017 Feb 24;12(2):e0172773. doi: 10.1371/journal.pone.0172773. eCollection 2017.

Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions
Abdul-Muneer PM, Alikunju S, Mishra V, Schuetz H, Szlachetka AM, Burnham EL, Haorah J.
Brain Behav Immun. 2017 May;62:291-305. doi: 10.1016/j.bbi.2017.02.014. Epub 2017 Feb 21.

Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase.
Liu X, Pichulik T, Wolz OO, Dang TM, Stutz A, Dillen C, Delmiro Garcia M, Kraus H, Dickhöfer S, Daiber E, Münzenmayer L, Wahl S, Rieber N, Kümmerle-Deschner J, Yazdi A, Franz-Wachtel M, Macek B, Radsak M, Vogel S, Schulte B, Walz JS, Hartl D, Latz E, Stilgenbauer S, Grimbacher B, Miller L, Brunner C, Wolz C, Weber ANR.
J Allergy Clin Immunol. 2017 Oct;140(4):1054-1067.e10. doi: 10.1016/j.jaci.2017.01.017. Epub 2017 Feb 16.

A novel mechanism of diabetic vascular endothelial dysfunction: Hypoadiponectinemia-induced NLRP3 inflammasome activation.
Zhang J, Xia L, Zhang F, Zhu D, Xin C, Wang H, Zhang F, Guo X, Lee Y, Zhang L, Wang S, Guo X, Huang C, Gao F, Liu Y, Tao L.
Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1556-1567. doi: 10.1016/j.bbadis.2017.02.012. Epub 2017 Feb 13.

Triptolide attenuates pressure overload-induced myocardial remodeling in mice via the inhibition of NLRP3 inflammasome expression.
Li R, Lu K, Wang Y, Chen M, Zhang F, Shen H, Yao D, Gong K, Zhang Z.
Biochem Biophys Res Commun. 2017 Mar 25;485(1):69-75. doi: 10.1016/j.bbrc.2017.02.021. Epub 2017 Feb 12.

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats.
Yu C, He Q, Zheng J, Li LY, Hou YH, Song FZ.
Int Immunopharmacol. 2017 Apr;45:74-78. doi: 10.1016/j.intimp.2017.01.034. Epub 2017 Feb 10.

Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke.
Lee HI, Lee SW, Kim NG, Park KJ, Choi BT, Shin YI, Shin HK.
J Biophotonics. 2017 Nov;10(11):1502-1513. doi: 10.1002/jbio.201600244. Epub 2017 Feb 6.

NLRP3 Inflammasome Expression and Signaling in Human Diabetic Wounds and in High Glucose Induced Macrophages.
Zhang X, Dai J, Li L, Chen H, Chai Y.
J Diabetes Res. 2017;2017:5281358. doi: 10.1155/2017/5281358. Epub 2017 Jan 10.

Isorhamnetin and hyperoside derived from water dropwort inhibits inflammasome activation.
Ahn H, Lee GS.
Phytomedicine. 2017 Jan 15;24:77-86. doi: 10.1016/j.phymed.2016.11.019. Epub 2016 Nov 23.

NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.
Wu D, Ren P, Zheng Y, Zhang L, Xu G, Xie W, Lloyd EE, Zhang S, Zhang Q, Curci JA, Coselli JS, Milewicz DM, Shen YH, LeMaire SA.
Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):694-706. doi: 10.1161/ATVBAHA.116.307648. Epub 2017 Feb 2.

Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis.
Domiciano TP, Wakita D, Jones HD, Crother TR, Verri WA Jr, Arditi M, Shimada K.
Sci Rep. 2017 Feb 2;7:41539. doi: 10.1038/srep41539.

 The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population.
Zhang K, Song W, Li D, Yan J, Chen Y, Qi H, Jin X, Zhao J.
Cell Physiol Biochem. 2017;41(1):173-180. doi: 10.1159/000455986. Epub 2017 Jan 18.

Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke.
Qin YY, Li M, Feng X, Wang J, Cao L, Shen XK, Chen J, Sun M, Sheng R, Han F, Qin ZH.
Free Radic Biol Med. 2017 Mar;104:333-345. doi: 10.1016/j.freeradbiomed.2017.01.034. Epub 2017 Jan 26. Erratum in: Free Radic Biol Med. 2017 Dec 27;:

The cardioprotective effect of total flavonoids on myocardial ischemia/reperfusion in rats.
Lv D, Cheng X, Tang L, Jiang M.
Biomed Pharmacother. 2017 Apr;88:277-284. doi: 10.1016/j.biopha.2017.01.060. Epub 2017 Jan 19.

Thyroid hormone suppresses ischemia-reperfusion-induced liver NLRP3 inflammasome activation: Role of AMP-activated protein kinase.
Vargas R, Videla LA.
Immunol Lett. 2017 Apr;184:92-97. doi: 10.1016/j.imlet.2017.01.007. Epub 2017 Jan 18.

Inflammasome Priming in Sterile Inflammatory Disease.
Patel MN, Carroll RG, Galván-Peña S, Mills EL, Olden R, Triantafilou M, Wolf AI, Bryant CE, Triantafilou K, Masters SL.
Trends Mol Med. 2017 Feb;23(2):165-180. doi: 10.1016/j.molmed.2016.12.007. Epub 2017 Jan 18. Review.

The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE-/-Mice.
Leng W, Ouyang X, Lei X, Wu M, Chen L, Wu Q, Deng W, Liang Z.
Mediators Inflamm. 2016;2016:6305735. doi: 10.1155/2016/6305735. Epub 2016 Dec 26.

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice.
Fuster JJ, MacLauchlan S, Zuriaga MA, Polackal MN, Ostriker AC, Chakraborty R, Wu CL, Sano S, Muralidharan S, Rius C, Vuong J, Jacob S, Muralidhar V, Robertson AA, Cooper MA, Andrés V, Hirschi KK, Martin KA, Walsh K.
Science. 2017 Feb 24;355(6327):842-847. doi: 10.1126/science.aag1381. Epub 2017 Jan 19.

Are the innate and adaptive immune systems setting hypertension on fire?
Bomfim GF, Rodrigues FL, Carneiro FS.
Pharmacol Res. 2017 Mar;117:377-393. doi: 10.1016/j.phrs.2017.01.010. Epub 2017 Jan 16. Review.

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke.
Fann DY, Lim YA, Cheng YL, Lok KZ, Chunduri P, Baik SH, Drummond GR, Dheen ST, Sobey CG, Jo DG, Chen CL, Arumugam TV.
Mol Neurobiol. 2018 Feb;55(2):1082-1096. doi: 10.1007/s12035-017-0394-9. Epub 2017 Jan 14.

Reperfusion therapy with recombinant human relaxin-2 (Serelaxin) attenuates myocardial infarct size and NLRP3 inflammasome following ischemia/reperfusion injury via eNOS-dependent mechanism.
Valle Raleigh J, Mauro AG, Devarakonda T, Marchetti C, He J, Kim E, Filippone S, Das A, Toldo S, Abbate A, Salloum FN.
Cardiovasc Res. 2017 May 1;113(6):609-619. doi: 10.1093/cvr/cvw246.

Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway.
Yin Y, Zhou Z, Liu W, Chang Q, Sun G, Dai Y.
Int J Biochem Cell Biol. 2017 Mar;84:22-34. doi: 10.1016/j.biocel.2017.01.001. Epub 2017 Jan 4.

NLRP3 inflammasome: common nexus between depression and cardiovascular diseases.
Alcocer-Gómez E, Cordero MD.
Nat Rev Cardiol. 2017 Feb;14(2):124. doi: 10.1038/nrcardio.2016.214. Epub 2017 Jan 5. No abstract available. 

Reply: NLRP3 inflammasome as a mechanism linking depression and cardiovascular diseases.
Carney RM, Freedland KE.
Nat Rev Cardiol. 2017 Feb;14(2):124. doi: 10.1038/nrcardio.2016.215. Epub 2017 Jan 5. No abstract available. 

Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways.
Mastrocola R, Penna C, Tullio F, Femminò S, Nigro D, Chiazza F, Serpe L, Collotta D, Alloatti G, Cocco M, Bertinaria M, Pagliaro P, Aragno M, Collino M.
Oxid Med Cell Longev. 2016;2016:5271251. doi: 10.1155/2016/5271251. Epub 2016 Dec 8.

The NLRP3 inflammasome and bruton’s tyrosine kinase in platelets co-regulate platelet activation, aggregation, and in vitro thrombus formation.
Murthy P, Durco F, Miller-Ocuin JL, Takedai T, Shankar S, Liang X, Liu X, Cui X, Sachdev U, Rath D, Lotze MT, Zeh HJ 3rd, Gawaz M, Weber AN, Vogel S.
Biochem Biophys Res Commun. 2017 Jan 29;483(1):230-236. doi: 10.1016/j.bbrc.2016.12.161. Epub 2016 Dec 26.

Signal transduction analysis of the NLRP3-inflammasome pathway after cellular damage and its paracrine regulation.
Veltman D, Laeremans T, Passante E, Huber HJ.
J Theor Biol. 2017 Feb 21;415:125-136. doi: 10.1016/j.jtbi.2016.12.016. Epub 2016 Dec 22.

Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms.
Li M, Li H, Fang F, Deng X, Ma S.
Neurosci Lett. 2017 Feb 3;639:114-119. doi: 10.1016/j.neulet.2016.12.046. Epub 2016 Dec 21.

Exogenous Hydrogen Sulfide Attenuates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3Inflammasome Activation by Suppressing TLR4/NF-κB Pathway in H9c2 Cells.
Huang Z, Zhuang X, Xie C, Hu X, Dong X, Guo Y, Li S, Liao X.
Cell Physiol Biochem. 2016;40(6):1578-1590. doi: 10.1159/000453208. Epub 2016 Dec 21.

A brain in flame; do inflammasomes and pyroptosis influence stroke pathology?
Barrington J, Lemarchand E, Allan SM.
Brain Pathol. 2017 Mar;27(2):205-212. doi: 10.1111/bpa.12476. Review.

Hyperuricemia: A causal player or a bystander linking inflammatory signaling and atrial fibrillation?
Li N, Dobrev D.
Int J Cardiol. 2017 Mar 15;231:177-178. doi: 10.1016/j.ijcard.2016.12.018. Epub 2016 Dec 6. No abstract available. 

PEDF Inhibits the Activation of NLRP3 Inflammasome in Hypoxia Cardiomyocytes through PEDF Receptor/Phospholipase A2.
Zhou Z, Wang Z, Guan Q, Qiu F, Li Y, Liu Z, Zhang H, Dong H, Zhang Z.
Int J Mol Sci. 2016 Dec 12;17(12). pii: E2064.

Could NLRP3-Inflammasome Be a Cardiovascular Risk Biomarker in Acute Myocardial Infarction Patients?
Bullón P, Cano-García FJ, Alcocer-Gómez E, Varela-López A, Roman-Malo L, Ruiz-Salmerón RJ, Quiles JL, Navarro-Pando JM, Battino M, Ruiz-Cabello J, Jiménez-Borreguero LJ, Cordero MD.
Antioxid Redox Signal. 2017 Aug 10;27(5):269-275. doi: 10.1089/ars.2016.6970. Epub 2017 Jan 20.

The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome.
Traba J, Sack MN.
Cell Mol Life Sci. 2017 May;74(10):1777-1791. doi: 10.1007/s00018-016-2431-7. Epub 2016 Dec 10. Review.

NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH.
Yao ST, Cao F, Chen JL, Chen W, Fan RM, Li G, Zeng YC, Jiao S, Xia XP, Han C, Ran QS.
J Mol Neurosci. 2017 Mar;61(3):385-395. doi: 10.1007/s12031-016-0874-9. Epub 2016 Dec 8.

[Effect of NLRP3 inflammasome on vascular diseases].
Cao Z, Li Y, Chen R, Zeng P.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Nov 28;41(11):1232-1236. Review. Chinese. 

Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells.
Li Y, Yang X, He Y, Wang W, Zhang J, Zhang W, Jing T, Wang B, Lin R.
Immunobiology. 2017 Mar;222(3):552-561. doi: 10.1016/j.imbio.2016.11.002. Epub 2016 Nov 4.

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice.
Monnerat G, Alarcón ML, Vasconcellos LR, Hochman-Mendez C, Brasil G, Bassani RA, Casis O, Malan D, Travassos LH, Sepúlveda M, Burgos JI, Vila-Petroff M, Dutra FF, Bozza MT, Paiva CN, Carvalho AB, Bonomo A, Fleischmann BK, de Carvalho ACC, Medei E.
Nat Commun. 2016 Nov 24;7:13344. doi: 10.1038/ncomms13344.

Statin protects the heart against ischemia-reperfusion injury via inhibition of the NLRP3inflammasome.
Yu SY, Tang L, Zhao GJ, Zhou SH.
Int J Cardiol. 2017 Feb 15;229:23-24. doi: 10.1016/j.ijcard.2016.11.219. Epub 2016 Nov 9. No abstract available. 

L5-LDL from ST-elevation myocardial infarction patients induces IL-1β production via LOX-1 and NLRP3 inflammasome activation in macrophages.
Yang TC, Chang PY, Lu SC.
Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H265-H274. doi: 10.1152/ajpheart.00509.2016. Epub 2016 Nov 18.

Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke.
Lu Y, Xiao G, Luo W.
Neuroimmunomodulation. 2016;23(4):230-238. doi: 10.1159/000452172. Epub 2016 Nov 16.

NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17β-Estradiol.
Thakkar R, Wang R, Sareddy G, Wang J, Thiruvaiyaru D, Vadlamudi R, Zhang Q, Brann D.
Oxid Med Cell Longev. 2016;2016:8309031. Epub 2016 Oct 23.

Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via Adenosine.
Birnbaum Y, Birnbaum GD, Birnbaum I, Nylander S, Ye Y.
Cardiovasc Drugs Ther. 2016 Dec;30(6):539-550.

NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular Damage.
Bruder-Nascimento T, Ferreira NS, Zanotto CZ, Ramalho F, Pequeno IO, Olivon VC, Neves KB, Alves-Lopes R, Campos E, Silva CA, Fazan R, Carlos D, Mestriner FL, Prado D, Pereira FV, Braga T, Luiz JP, Cau SB, Elias PC, Moreira AC, Câmara NO, Zamboni DS, Alves-Filho JC, Tostes RC.
Circulation. 2016 Dec 6;134(23):1866-1880. Epub 2016 Nov 1.

Naoxintong attenuates Ischaemia/reperfusion Injury through inhibiting NLRP3 inflammasome activation.
Wang Y, Yan X, Mi S, Li Z, Wang Y, Zhu H, Sun X, Zhao B, Zhao C, Zou Y, Hu K, Ding X, Sun A, Ge J.
J Cell Mol Med. 2017 Jan;21(1):4-12. doi: 10.1111/jcmm.12915. Epub 2016 Oct 26.

Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline.
Chen W, Zhao M, Zhao S, Lu Q, Ni L, Zou C, Lu L, Xu X, Guan H, Zheng Z, Qiu Q.
Inflamm Res. 2017 Feb;66(2):157-166. doi: 10.1007/s00011-016-1002-6. Epub 2016 Oct 26.

Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction.
Chen Y, Wang L, Pitzer AL, Li X, Li PL, Zhang Y.
J Mol Med (Berl). 2016 Dec;94(12):1335-1347. doi: 10.1007/s00109-016-1481-5. Epub 2016 Oct 25.

Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-κB and P2X7R Signaling in PMA-Induced Macrophages.
Kong F, Ye B, Cao J, Cai X, Lin L, Huang S, Huang W, Huang Z.
Front Pharmacol. 2016 Oct 10;7:369. eCollection 2016.

The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3inflammasome via AMPK signaling.
Qiu J, Wang M, Zhang J, Cai Q, Lu D, Li Y, Dong Y, Zhao T, Chen H.
Int Immunopharmacol. 2016 Nov;40:492-500. doi: 10.1016/j.intimp.2016.09.024. Epub 2016 Oct 18.

The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury.
Yue S, Zhu J, Zhang M, Li C, Zhou X, Zhou M, Ke M, Busuttil RW, Ying QL, Kupiec-Weglinski JW, Xia Q, Ke B.
Hepatology. 2016 Nov;64(5):1683-1698. doi: 10.1002/hep.28739. Epub 2016 Aug 29.

Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease.
Alphonse MP, Duong TT, Shumitzu C, Hoang TL, McCrindle BW, Franco A, Schurmans S, Philpott DJ, Hibberd ML, Burns J, Kuijpers TW, Yeung RS.
J Immunol. 2016 Nov 1;197(9):3481-3489. Epub 2016 Sep 30.

Complement activation by cholesterol crystals triggers a subsequent cytokine response.
Niyonzima N, Halvorsen B, Sporsheim B, Garred P, Aukrust P, Mollnes TE, Espevik T.
Mol Immunol. 2017 Apr;84:43-50. doi: 10.1016/j.molimm.2016.09.019. Epub 2016 Sep 28. Review.

Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation.
Wang L, Chen Y, Li X, Zhang Y, Gulbins E, Zhang Y.
Oncotarget. 2016 Nov 8;7(45):73229-73241. doi: 10.18632/oncotarget.12302.

Pterostilbene Attenuates Early Brain Injury Following Subarachnoid Hemorrhage via Inhibition of the NLRP3 Inflammasome and Nox2-Related Oxidative Stress.
Liu H, Zhao L, Yue L, Wang B, Li X, Guo H, Ma Y, Yao C, Gao L, Deng J, Li L, Feng D, Qu Y.
Mol Neurobiol. 2017 Oct;54(8):5928-5940. doi: 10.1007/s12035-016-0108-8. Epub 2016 Sep 24.

Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells.
Li Y, Yang G, Yang X, Wang W, Zhang J, He Y, Zhang W, Jing T, Lin R.
Int Immunopharmacol. 2016 Nov;40:211-218. doi: 10.1016/j.intimp.2016.09.003. Epub 2016 Sep 8.

Autoinflammatory associated vasculitis.
Ginsberg S, Rosner I, Rozenbaum M, Slobodin G, Zilber K, Boulman N, Kaly L, Awisat A, Jiries N, Beyar-Katz O, Rimar D.
Semin Arthritis Rheum. 2016 Dec;46(3):367-371. doi: 10.1016/j.semarthrit.2016.07.007. Epub 2016 Jul 20.

Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway.
Cao G, Jiang N, Hu Y, Zhang Y, Wang G, Yin M, Ma X, Zhou K, Qi J, Yu B, Kou J.
Int J Mol Sci. 2016 Aug 29;17(9). pii: E1418. doi: 10.3390/ijms17091418.

NLRP3 inflammasome: a promising target in ischemic stroke.
Gao L, Dong Q, Song Z, Shen F, Shi J, Li Y.
Inflamm Res. 2017 Jan;66(1):17-24. doi: 10.1007/s00011-016-0981-7. Epub 2016 Aug 30. Review.

Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis.
López-Mejías R, Genre F, Remuzgo-Martínez S, González-Juanatey C, Robustillo-Villarino M, Llorca J, Corrales A, Vicente E, Miranda-Filloy JA, Magro C, Tejera-Segura B, Ramírez Huaranga MA, Pina T, Blanco R, Alegre-Sancho JJ, Raya E, Mijares V, Ubilla B, Mínguez Sánchez MD, Gómez-Vaquero C, Balsa A, Pascual-Salcedo D, López-Longo FJ, Carreira P, González-Álvaro I, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, Ferraz-Amaro I, Castañeda S, Martín J, González-Gay MA.
Sci Rep. 2016 Aug 18;6:31979. doi: 10.1038/srep31979.

Kinetic mRNA Profiling in a Rat Model of Left-Ventricular Hypertrophy Reveals Early Expression of Chemokines and Their Receptors.
Nemska S, Monassier L, Gassmann M, Frossard N, Tavakoli R.
PLoS One. 2016 Aug 15;11(8):e0161273. doi: 10.1371/journal.pone.0161273. eCollection 2016.

MicroRNA-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts.
Qin D, Wang X, Li Y, Yang L, Wang R, Peng J, Essandoh K, Mu X, Peng T, Han Q, Yu KJ, Fan GC.
J Biol Chem. 2016 Sep 16;291(38):20247-59. doi: 10.1074/jbc.M116.732735. Epub 2016 Aug 8.

Inflammation: Targeting the NLRP3 inflammasome after MI.
Lim GB.
Nat Rev Cardiol. 2016 Sep;13(9):506. doi: 10.1038/nrcardio.2016.122. Epub 2016 Aug 4. No abstract available. 

Inflammasomes link vascular disease with neuroinflammation and brain disorders.
Lénárt N, Brough D, Dénes Á.
J Cereb Blood Flow Metab. 2016 Oct;36(10):1668-1685. Epub 2016 Aug 2. Review.

Sex- and disease-specific inflammasome signatures in circulating blood leukocytes of patients with abdominal aortic aneurysm.
Wu X, Cakmak S, Wortmann M, Hakimi M, Zhang J, Böckler D, Dihlmann S.
Mol Med. 2016 Oct;22:505-518. doi: 10.2119/molmed.2016.00035. Epub 2016 Jul 29.

Atorvastatin suppresses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB signaling in PMA-stimulated THP-1 monocytes.
Kong F, Ye B, Lin L, Cai X, Huang W, Huang Z.
Biomed Pharmacother. 2016 Aug;82:167-72. doi: 10.1016/j.biopha.2016.04.043. Epub 2016 May 9.

NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis.
Zhao X, Gu C, Yan C, Zhang X, Li Y, Wang L, Ren L, Zhang Y, Peng J, Zhu Z, Han Y.
Biomed Res Int. 2016;2016:7395627. doi: 10.1155/2016/7395627. Epub 2016 Jun 30.

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction.
van Hout GP, Bosch L, Ellenbroek GH, de Haan JJ, van Solinge WW, Cooper MA, Arslan F, de Jager SC, Robertson AA, Pasterkamp G, Hoefer IE.
Eur Heart J. 2017 Mar 14;38(11):828-836. doi: 10.1093/eurheartj/ehw247.

p38δ MAPK: A Novel Regulator of NLRP3 Inflammasome Activation With Increased Expression in Coronary Atherogenesis.
Rajamäki K, Mäyränpää MI, Risco A, Tuimala J, Nurmi K, Cuenda A, Eklund KK, Öörni K, Kovanen PT.
Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1937-46. doi: 10.1161/ATVBAHA.115.307312. Epub 2016 Jul 14.

Ursodeoxycholic acid impairs atherogenesis and promotes plaque regression by cholesterol crystal dissolution in mice.
Bode N, Grebe A, Kerksiek A, Lütjohann D, Werner N, Nickenig G, Latz E, Zimmer S.
Biochem Biophys Res Commun. 2016 Sep 9;478(1):356-362. doi: 10.1016/j.bbrc.2016.07.047. Epub 2016 Jul 11.

NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation.
Li H, Zhang S, Li F, Qin L.
Mol Immunol. 2016 Aug;76:90-7. doi: 10.1016/j.molimm.2016.06.013. Epub 2016 Jul 6.

Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis.
Tumurkhuu G, Shimada K, Dagvadorj J, Crother TR, Zhang W, Luthringer D, Gottlieb RA, Chen S, Arditi M.
Circ Res. 2016 Sep 2;119(6):e76-90. doi: 10.1161/CIRCRESAHA.116.308362. Epub 2016 Jul 6.

Elevated levels of triglycerides and vldl-cholesterol provoke activation of nlrp1 inflammasome in endothelial cells.
Bleda S, de Haro J, Varela C, Ferruelo A, Acin F.
Int J Cardiol. 2016 Oct 1;220:52-5. doi: 10.1016/j.ijcard.2016.06.193. Epub 2016 Jun 25.

Post-translational regulation of inflammasomes.
Yang J, Liu Z, Xiao TS.
Cell Mol Immunol. 2017 Jan;14(1):65-79. doi: 10.1038/cmi.2016.29. Epub 2016 Jun 27. Review.

High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation.
Thacker SG, Zarzour A, Chen Y, Alcicek MS, Freeman LA, Sviridov DO, Demosky SJ Jr, Remaley AT.
Immunology. 2016 Nov;149(3):306-319. doi: 10.1111/imm.12638. Epub 2016 Aug 28.

Dousing fire with gasoline: interplay between lysosome damage and the NLRP3 inflammasome. Focus on “NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx”.
Schilling JD.
Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C81-2. doi: 10.1152/ajpcell.00174.2016. Epub 2016 Jun 15. No abstract available. 

Endothelial ATP-binding cassette G1 in mouse endothelium protects against hemodynamic-induced atherosclerosis.
Xue S, Wang J, Zhang X, Shi Y, Li B, Bao Q, Pang W, Ai D, Zhu Y, He J.
Biochem Biophys Res Commun. 2016 Aug 19;477(2):247-54. doi: 10.1016/j.bbrc.2016.06.050. Epub 2016 Jun 11.

Control of the innate immune response by the mevalonate pathway.
Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D.
Nat Immunol. 2016 Aug;17(8):922-9. doi: 10.1038/ni.3487. Epub 2016 Jun 6.

Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation.
Kang LL, Zhang DM, Ma CH, Zhang JH, Jia KK, Liu JH, Wang R, Kong LD
Sci Rep. 2016 Jun 8;6:27460. doi: 10.1038/srep27460.

Inflammasome and toll-like receptor signaling in human monocytes after successful cardiopulmonary resuscitation.
Asmussen A, Fink K, Busch HJ, Helbing T, Bourgeois N, Bode C, Grundmann S.
Crit Care. 2016 Jun 4;20(1):170. doi: 10.1186/s13054-016-1340-3.

Colchicine to decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation.
Demidowich AP, Davis AI, Dedhia N, Yanovski JA.
Med Hypotheses. 2016 Jul;92:67-73. doi: 10.1016/j.mehy.2016.04.039. Epub 2016 Apr 25.

NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity.
Kobayashi M, Usui F, Karasawa T, Kawashima A, Kimura H, Mizushina Y, Shirasuna K, Mizukami H, Kasahara T, Hasebe N, Takahashi M.
Sci Rep. 2016 May 26;6:26489. doi: 10.1038/srep26489.

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis.
Paramel Varghese G, Folkersen L, Strawbridge RJ, Halvorsen B, Yndestad A, Ranheim T, Krohg-Sørensen K, Skjelland M, Espevik T, Aukrust P, Lengquist M, Hedin U, Jansson JH, Fransén K, Hansson GK, Eriksson P, Sirsjö A.
J Am Heart Assoc. 2016 May 20;5(5). pii: e003031. doi: 10.1161/JAHA.115.003031.

ssociation of EGF Receptor and NLRs signaling with Cardiac Inflammation and Fibrosis in Mice Exposed to Fine Particulate Matter.
Jin Y, Wu Z, Wang N, Duan S, Wu Y, Wang J, Wu W, Feng F.
J Biochem Mol Toxicol. 2016 Sep;30(9):429-37. doi: 10.1002/jbt.21806. Epub 2016 May 9.

The novel TLR9 antagonist COV08-0064 protects from ischemia/reperfusion injury in non-steatotic and steatotic mice livers.
Shaker ME, Trawick BN, Mehal WZ.
Biochem Pharmacol. 2016 Jul 15;112:90-101. doi: 10.1016/j.bcp.2016.05.003. Epub 2016 May 6.

Probenecid protects against oxygen-glucose deprivation injury in primary astrocytes by regulating inflammasome activity.
Jian Z, Ding S, Deng H, Wang J, Yi W, Wang L, Zhu S, Gu L, Xiong X.
Brain Res. 2016 Jul 15;1643:123-9. doi: 10.1016/j.brainres.2016.05.002. Epub 2016 May 3.

Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3inflammasome monocyte activation.
Robertson S, Martínez GJ, Payet CA, Barraclough JY, Celermajer DS, Bursill C, Patel S.
Clin Sci (Lond). 2016 Jul 1;130(14):1237-46. doi: 10.1042/CS20160090. Epub 2016 Apr 21.

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury.
Minutoli L, Puzzolo D, Rinaldi M, Irrera N, Marini H, Arcoraci V, Bitto A, Crea G, Pisani A, Squadrito F, Trichilo V, Bruschetta D, Micali A, Altavilla D.
Oxid Med Cell Longev. 2016;2016:2183026. doi: 10.1155/2016/2183026. Epub 2016 Apr 5. Review.

The NLRP3 rs10754558 Polymorphism Is Associated with the Occurrence and Prognosis of Coronary Artery Disease in the Chinese Han Population.
Zhou D, Wang X, Chen T, Wen W, Liu Y, Wu Y, Yuan Z.
Biomed Res Int. 2016;2016:3185397. doi: 10.1155/2016/3185397. Epub 2016 Mar 24.

Response to letter from Toldo et al. on “NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective”.
Yndestad A, Sandanger Ø, Jong WMC, Aukrust P, Zuurbier CJ.
Biochem Biophys Res Commun. 2016 May 27;474(2):328-329. doi: 10.1016/j.bbrc.2016.04.096. Epub 2016 Apr 22. No abstract available. 

Glutamine Modulates Macrophage Lipotoxicity.
He L, Weber KJ, Schilling JD.
Nutrients. 2016 Apr 12;8(4):215. doi: 10.3390/nu8040215.

Nafamostat mesilate improves function recovery after stroke by inhibiting neuroinflammation in rats.
Li C, Wang J, Fang Y, Liu Y, Chen T, Sun H, Zhou XF, Liao H.
Brain Behav Immun. 2016 Aug;56:230-45. doi: 10.1016/j.bbi.2016.03.019. Epub 2016 Mar 24.

Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial Cells.
Xi H, Zhang Y, Xu Y, Yang WY, Jiang X, Sha X, Cheng X, Wang J, Qin X, Yu J, Ji Y, Yang X, Wang H.
Circ Res. 2016 May 13;118(10):1525-39. doi: 10.1161/CIRCRESAHA.116.308501. Epub 2016 Mar 22.

Disease-Induced Neuroinflammation and Depression.
Benatti C, Blom JM, Rigillo G, Alboni S, Zizzi F, Torta R, Brunello N, Tascedda F.
CNS Neurol Disord Drug Targets. 2016;15(4):414-33. Review.

NLRP3 Is Involved in Ischemia/Reperfusion Injury.
Guo Z, Yu S, Chen X, Ye R, Zhu W, Liu X.
CNS Neurol Disord Drug Targets. 2016;15(6):699-712. Review.

Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation.
Souza AC, Bocharov AV, Baranova IN, Vishnyakova TG, Huang YG, Wilkins KJ, Hu X, Street JM, Alvarez-Prats A, Mullick AE, Patterson AP, Remaley AT, Eggerman TL, Yuen PS, Star RA.
Kidney Int. 2016 Apr;89(4):809-22. doi: 10.1016/j.kint.2015.12.043.

Crosstalk between the heart and peripheral organs in heart failure.
Jahng JW, Song E, Sweeney G.
Exp Mol Med. 2016 Mar 11;48:e217. doi: 10.1038/emm.2016.20. Review.

Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease-Associated Abdominal Aortic Aneurysm.
Wakita D, Kurashima Y, Crother TR, Noval Rivas M, Lee Y, Chen S, Fury W, Bai Y, Wagner S, Li D, Lehman T, Fishbein MC, Hoffman HM, Shah PK, Shimada K, Arditi M.
Arterioscler Thromb Vasc Biol. 2016 May;36(5):886-97. doi: 10.1161/ATVBAHA.115.307072. Epub 2016 Mar 3.

Increased M1 Macrophages Infiltration Is Associated with Thrombogenesis in Rheumatic Mitral Stenosis Patients with Atrial Fibrillation.
He G, Tan W, Wang B, Chen J, Li G, Zhu S, Xie J, Xu B.
PLoS One. 2016 Mar 1;11(3):e0149910. doi: 10.1371/journal.pone.0149910. eCollection 2016.

MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1.
Jeyabal P, Thandavarayan RA, Joladarashi D, Suresh Babu S, Krishnamurthy S, Bhimaraj A, Youker KA, Kishore R, Krishnamurthy P.
Biochem Biophys Res Commun. 2016 Mar 18;471(4):423-9. doi: 10.1016/j.bbrc.2016.02.065. Epub 2016 Feb 17.

Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia-reperfusion in the mouse.
Toldo S, Marchetti C, Mauro AG, Chojnacki J, Mezzaroma E, Carbone S, Zhang S, Van Tassell B, Salloum FN, Abbate A.
Int J Cardiol. 2016 Apr 15;209:215-20. doi: 10.1016/j.ijcard.2016.02.043. Epub 2016 Feb 4.

NLRP3 deletion protects against renal fibrosis and attenuates mitochondrial abnormality in mouse with 5/6 nephrectomy.
Gong W, Mao S, Yu J, Song J, Jia Z, Huang S, Zhang A.
Am J Physiol Renal Physiol. 2016 May 15;310(10):F1081-8. doi: 10.1152/ajprenal.00534.2015. Epub 2016 Feb 17.

Upregulation of inflammasome activity and increased gut permeability are associated with obesity in children and adolescents.
Rainone V, Schneider L, Saulle I, Ricci C, Biasin M, Al-Daghri NM, Giani E, Zuccotti GV, Clerici M, Trabattoni D.
Int J Obes (Lond). 2016 Jun;40(6):1026-33. doi: 10.1038/ijo.2016.26. Epub 2016 Feb 15.

Inhibition of Mitochondrial Fission and NOX2 Expression Prevent NLRP3 Inflammasome Activation in the Endothelium: The Role of Corosolic Acid Action in the Amelioration of Endothelial Dysfunction.
Li Y, Zhou ZH, Chen MH, Yang J, Leng J, Cao GS, Xin GZ, Liu LF, Kou JP, Liu BL, Li P, Wen XD.
Antioxid Redox Signal. 2016 Jun 1;24(16):893-908. doi: 10.1089/ars.2015.6479. Epub 2016 Mar 22.

Saikosaponin-a Attenuates Oxidized LDL Uptake and Prompts Cholesterol Efflux in THP-1 Cells.
He D, Wang H, Xu L, Wang X, Peng K, Wang L, Liu P, Qu P.
J Cardiovasc Pharmacol. 2016 Jun;67(6):510-8. doi: 10.1097/FJC.0000000000000373.

Genetic Variations of NLR family genes in Behcet’s Disease.
Li L, Yu H, Jiang Y, Deng B, Bai L, Kijlstra A, Yang P.
Sci Rep. 2016 Feb 1;6:20098. doi: 10.1038/srep20098. Erratum in: Sci Rep. 2016 May 31;6:26423

Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells.
Chen H, Lu Y, Cao Z, Ma Q, Pi H, Fang Y, Yu Z, Hu H, Zhou Z.
Toxicol Lett. 2016 Mar 30;246:7-16. doi: 10.1016/j.toxlet.2016.01.014. Epub 2016 Jan 22.

Re. “NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective”.
Toldo S, Marchetti C, Abbate A.
Biochem Biophys Res Commun. 2016 Feb 19;470(4):811-2. doi: 10.1016/j.bbrc.2016.01.088. Epub 2016 Jan 19. No abstract available. 

Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice.
Mastrocola R, Collino M, Penna C, Nigro D, Chiazza F, Fracasso V, Tullio F, Alloatti G, Pagliaro P, Aragno M.
Oxid Med Cell Longev. 2016;2016:3480637. doi: 10.1155/2016/3480637. Epub 2015 Dec 14.

N-methyl-D-aspartic acid receptor 1 (NMDAR1) aggravates secondary inflammatory damage induced by hemin-NLRP3 pathway after intracerebral hemorrhage.
Weng X, Tan Y, Chu X, Wu XF, Liu R, Tian Y, Li L, Guo F, Ouyang Q, Li L.
Chin J Traumatol. 2015;18(5):254-8.

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis.
Sergin I, Bhattacharya S, Emanuel R, Esen E, Stokes CJ, Evans TD, Arif B, Curci JA, Razani B.
Sci Signal. 2016 Jan 5;9(409):ra2. doi: 10.1126/scisignal.aad5614.

NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective.
Sandanger Ø, Gao E, Ranheim T, Bliksøen M, Kaasbøll OJ, Alfsnes K, Nymo SH, Rashidi A, Ohm IK, Attramadal H, Aukrust P, Vinge LE, Yndestad A.
Biochem Biophys Res Commun. 2016 Jan 22;469(4):1012-20. doi: 10.1016/j.bbrc.2015.12.051. Epub 2015 Dec 17.

Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque.
Janoudi A, Shamoun FE, Kalavakunta JK, Abela GS.
Eur Heart J. 2016 Jul 1;37(25):1959-67. doi: 10.1093/eurheartj/ehv653. Epub 2015 Dec 24. Review.

A Polymorphism Within the 3’UTR of NLRP3 is Associated with Susceptibility for Ischemic Stroke in Chinese Population.
Zhu Z, Yan J, Geng C, Wang D, Li C, Feng S, Wang H.
Cell Mol Neurobiol. 2016 Aug;36(6):981-988. doi: 10.1007/s10571-015-0288-1. Epub 2015 Dec 21.

Adiponectin limits monocytic microparticle-induced endothelial activation by modulation of the AMPK, Akt and NFκB signaling pathways.
Ehsan M, Singh KK, Lovren F, Pan Y, Quan A, Mantella LE, Sandhu P, Teoh H, Al-Omran M, Verma S.
Atherosclerosis. 2016 Feb;245:1-11. doi: 10.1016/j.atherosclerosis.2015.11.024. Epub 2015 Nov 25.

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3inflammasome and apoptosis signaling.
Dong Y, Fan C, Hu W, Jiang S, Ma Z, Yan X, Deng C, Di S, Xin Z, Wu G, Yang Y, Reiter RJ, Liang G.
J Pineal Res. 2016 Apr;60(3):253-62. doi: 10.1111/jpi.12300. Epub 2016 Feb 15.

Atrial natriuretic peptide down-regulates LPS/ATP-mediated IL-1β release by inhibiting NF-kB, NLRP3inflammasome and caspase-1 activation in THP-1 cells.
Mezzasoma L, Antognelli C, Talesa VN.
Immunol Res. 2016 Feb;64(1):303-12. doi: 10.1007/s12026-015-8751-0.

Sepsis and ARDS: The Dark Side of Histones.
Xu Z, Huang Y, Mao P, Zhang J, Li Y.
Mediators Inflamm. 2015;2015:205054. doi: 10.1155/2015/205054. Epub 2015 Nov 1. Review.

Response to Letter Regarding Article, “Anti-inflammatory and Antiatherogenic Effects of the Inflammasome NLRP3 Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet”.
Abderrazak A, Couchie D, Darweesh Mahmood DF, Elhage R, Vindis C, Laffargue M, Matéo V, Büchele B, Ayala MR, Gaafary ME, Syrovets T, Slimane MN, Friguet B, Fulop T, Simmet T, Hadri KE, Rouis M.
Circulation. 2015 Nov 24;132(21):e250-1. doi: 10.1161/CIRCULATIONAHA.115.017739. No abstract available. 

Letter by Karasawa and Takahashi Regarding Article, “Anti-inflammatory and Antiatherogenic Effects of the Inflammasome NLRP3 Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet”.
Karasawa T, Takahashi M.
Circulation. 2015 Nov 24;132(21):e249. doi: 10.1161/CIRCULATIONAHA.115.016070. No abstract available. 

Plasticizer DBP Activates NLRP3 Inflammasome through the P2X7 Receptor in HepG2 and L02 Cells.
Ni J, Zhang Z, Luo X, Xiao L, Wang N.
J Biochem Mol Toxicol. 2016 Apr;30(4):178-85. doi: 10.1002/jbt.21776. Epub 2015 Nov 20.

[Research Advances in NLRP3 Inflammasome-related Regulatory Mechanisms].
Wang CY, Guo XC, Zhang JP.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2015 Oct;37(5):618-22. doi: 10.3881/j.issn.1000-503X.2015.05.022. Chinese. 

Gain-of-function somatic mutations contribute to inflammation and blood vessel damage that lead to Alzheimer dementia: a hypothesis.
Marchesi VT.
FASEB J. 2016 Feb;30(2):503-6. doi: 10.1096/fj.15-282285. Epub 2015 Nov 2.

IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1α and IL-1β.
Lee Y, Wakita D, Dagvadorj J, Shimada K, Chen S, Huang G, Lehman TJ, Fishbein MC, Hoffman HM, Crother TR, Arditi M.
Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2605-16. doi: 10.1161/ATVBAHA.115.306475. Epub 2015 Oct 29.

Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis.
Rojas J, Salazar J, Martínez MS, Palmar J, Bautista J, Chávez-Castillo M, Gómez A, Bermúdez V.
Scientifica (Cairo). 2015;2015:851252. doi: 10.1155/2015/851252. Epub 2015 Sep 27. Review.

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite.
Feng L, Chen Y, Ding R, Fu Z, Yang S, Deng X, Zeng J.
J Neuroinflammation. 2015 Oct 17;12:190. doi: 10.1186/s12974-015-0409-2. Erratum in: J Neuroinflammation. 2016;13(1):186

Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats.
Zhao J, Mou Y, Bernstock JD, Klimanis D, Wang S, Spatz M, Maric D, Johnson K, Klinman DM, Li X, Li X, Hallenbeck JM.
PLoS One. 2015 Oct 16;10(10):e0140772. doi: 10.1371/journal.pone.0140772. eCollection 2015.

Resveratrol pretreatment protects rat hearts from ischemia/reperfusion injury partly via a NALP3 inflammasome pathway.
Dong W, Yang R, Yang J, Yang J, Ding J, Wu H, Zhang J.
Int J Clin Exp Pathol. 2015 Aug 1;8(8):8731-41. eCollection 2015.

Is immunity a mechanism contributing to statin-induced diabetes?
Henriksbo BD, Schertzer JD.
Adipocyte. 2015 Apr 20;4(4):232-8. doi: 10.1080/21623945.2015.1024394. eCollection 2015 Oct-Dec. Review.

Recombinant adenovirus encoding NLRP3 RNAi attenuate inflammation and brain injury after intracerebral hemorrhage.
Yuan B, Shen H, Lin L, Su T, Zhong S, Yang Z.
J Neuroimmunol. 2015 Oct 15;287:71-5. doi: 10.1016/j.jneuroim.2015.08.002. Epub 2015 Aug 7.

NF-κB Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1.
Qi J, Yu XJ, Shi XL, Gao HL, Yi QY, Tan H, Fan XY, Zhang Y, Song XA, Cui W, Liu JJ, Kang YM.
Cardiovasc Toxicol. 2016 Oct;16(4):345-54. doi: 10.1007/s12012-015-9344-9.

Targeting danger-associated molecular patterns after myocardial infarction.
van Hout GP, Arslan F, Pasterkamp G, Hoefer IE.
Expert Opin Ther Targets. 2016;20(2):223-39. doi: 10.1517/14728222.2016.1088005. Epub 2015 Sep 30. Review.

NLRP3 Inflammasome Involvement in the Organ Damage and Impaired Spermatogenesis Induced by Testicular Ischemia and Reperfusion in Mice.
Minutoli L, Antonuccio P, Irrera N, Rinaldi M, Bitto A, Marini H, Pizzino G, Romeo C, Pisani A, Santoro G, Puzzolo D, Magno C, Squadrito F, Micali A, Altavilla D.
J Pharmacol Exp Ther. 2015 Dec;355(3):370-80. doi: 10.1124/jpet.115.226936. Epub 2015 Sep 25.

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis.
Shi X, Xie WL, Kong WW, Chen D, Qu P.
J Stroke Cerebrovasc Dis. 2015 Nov;24(11):2455-66. doi: 10.1016/j.jstrokecerebrovasdis.2015.03.024. Epub 2015 Sep 15.

NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy.
Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura H, Kawashima A, Ohkuchi A, Taniguchi S, Takahashi M.
Endocrinology. 2015 Nov;156(11):4281-92. doi: 10.1210/en.2015-1408. Epub 2015 Sep 10.

Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain.
Lammerding L, Slowik A, Johann S, Beyer C, Zendedel A.
Neuroendocrinology. 2016;103(5):460-75. doi: 10.1159/000439435. Epub 2015 Aug 25.

Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome.
Martínez GJ, Robertson S, Barraclough J, Xia Q, Mallat Z, Bursill C, Celermajer DS, Patel S.
J Am Heart Assoc. 2015 Aug 24;4(8):e002128. doi: 10.1161/JAHA.115.002128.

Targeting Interleukin-1 beta to Suppress Sympathoexcitation in Hypothalamic Paraventricular Nucleus in Dahl Salt-Sensitive Hypertensive Rats.
Qi J, Zhao XF, Yu XJ, Yi QY, Shi XL, Tan H, Fan XY, Gao HL, Yue LY, Feng ZP, Kang YM.
Cardiovasc Toxicol. 2016 Jul;16(3):298-306. doi: 10.1007/s12012-015-9338-7.

Correlation of NLRP3 with severity and prognosis of coronary atherosclerosis in acute coronary syndrome patients.
Afrasyab A, Qu P, Zhao Y, Peng K, Wang H, Lou D, Niu N, Yuan D.
Heart Vessels. 2016 Aug;31(8):1218-29. doi: 10.1007/s00380-015-0723-8. Epub 2015 Aug 20.

Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis.
Bando S, Fukuda D, Soeki T, Nishimoto S, Uematsu E, Matsuura T, Ise T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
Atherosclerosis. 2015 Oct;242(2):407-14. doi: 10.1016/j.atherosclerosis.2015.07.043. Epub 2015 Jul 29.

Early Upregulation of NLRP3 in the Brain of Neonatal Mice Exposed to Hypoxia-Ischemia: No Early Neuroprotective Effects of NLRP3 Deficiency.
Ystgaard MB, Sejersted Y, Løberg EM, Lien E, Yndestad A, Saugstad OD.
Neonatology. 2015;108(3):211-9. doi: 10.1159/000437247. Epub 2015 Aug 13.

NLRP3 Inflammasome Polymorphism and Macrovascular Complications in Type 2 Diabetes Patients.
Klen J, Goričar K, Janež A, Dolžan V.
J Diabetes Res. 2015;2015:616747. doi: 10.1155/2015/616747. Epub 2015 Jul 27.

Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway.
Wang X, He G, Peng Y, Zhong W, Wang Y, Zhang B.
Sci Rep. 2015 Aug 3;5:12676. doi: 10.1038/srep12676.

Genetic Variants of the NLRP3 Inflammasome Are Associated with Stroke in Patients with Rheumatoid Arthritis.
Kastbom A, Ärlestig L, Rantapää-Dahlqvist S.
J Rheumatol. 2015 Oct;42(10):1740-5. doi: 10.3899/jrheum.141529. Epub 2015 Jul 15.

Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3inflammasome.
Sun C, Fan S, Wang X, Lu J, Zhang Z, Wu D, Shan Q, Zheng Y. 
Nutr Biochem. 2015 Oct;26(10):1029-40. doi: 10.1016/j.jnutbio.2015.04.012. Epub 2015 May 15.

Dysregulation of the NLRP3 inflammasome complex and related cytokines in patients with multiple myeloma.
Li Y, Li N, Yan Z, Li H, Chen L, Zhang Z, Fan G, Xu K, Li Z.
Hematology. 2016 Apr;21(3):144-51. doi: 10.1179/1607845415Y.0000000029. Epub 2015 Jul 6.

Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome.
Hu Q, Wei B, Wei L, Hua K, Yu X, Li H, Ji H.
Int J Cardiol. 2015 Oct 1;196:183-92. doi: 10.1016/j.ijcard.2015.05.152. Epub 2015 May 29.

Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage.
Li J, Chen J, Mo H, Chen J, Qian C, Yan F, Gu C, Hu Q, Wang L, Chen G.
Mol Neurobiol. 2016 May;53(4):2668-78. doi: 10.1007/s12035-015-9318-8. Epub 2015 Jul 5.

The NLRP3 inflammasome and stroke.
Tong Y, Ding ZH, Zhan FX, Cai L, Yin X, Ling JL, Ye JJ, Hou SY, Lu Z, Wang ZH, Liu JF.
Int J Clin Exp Med. 2015 Apr 15;8(4):4787-94. eCollection 2015. Review.

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice.
Krishnan SM, Dowling JK, Ling YH, Diep H, Chan CT, Ferens D, Kett MM, Pinar A, Samuel CS, Vinh A, Arumugam TV, Hewitson TD, Kemp-Harper BK, Robertson AA, Cooper MA, Latz E, Mansell A, Sobey CG, Drummond GR.
Br J Pharmacol. 2016 Feb;173(4):752-65. doi: 10.1111/bph.13230. Epub 2015 Jul 31.

Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3Inflammasome.
Shao A, Wu H, Hong Y, Tu S, Sun X, Wu Q, Zhao Q, Zhang J, Sheng J.
Mol Neurobiol. 2016 Jul;53(5):3462-3476. doi: 10.1007/s12035-015-9242-y. Epub 2015 Jun 20.

Umbelliferone ameliorates cerebral ischemia-reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome.
Wang X, Li R, Wang X, Fu Q, Ma S.
Neurosci Lett. 2015 Jul 23;600:182-7. doi: 10.1016/j.neulet.2015.06.016. Epub 2015 Jun 10.

Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.
Cero FT, Hillestad V, Sjaastad I, Yndestad A, Aukrust P, Ranheim T, Lunde IG, Olsen MB, Lien E, Zhang L, Haugstad SB, Løberg EM, Christensen G, Larsen KO, Skjønsberg OH.
Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L378-87. doi: 10.1152/ajplung.00342.2014. Epub 2015 Jun 12.

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.
Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, Morita R.
Nat Commun. 2015 Jun 10;6:7360. doi: 10.1038/ncomms8360.

Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner.
Li Y, Yang J, Chen MH, Wang Q, Qin MJ, Zhang T, Chen XQ, Liu BL, Wen XD.
Pharmacol Res. 2015 Sep;99:101-15. doi: 10.1016/j.phrs.2015.05.012. Epub 2015 Jun 6.

Moving with and beyond CANTOS: How to put out the fire of inflammation in atherosclerosis?
Cai Z, Shen L, He B.
Int J Cardiol. 2015 Sep 15;195:45-7. doi: 10.1016/j.ijcard.2015.05.123. Epub 2015 May 21. Review. No abstract available. 

The Importance of NLRP3 Inflammasome in Heart Failure.
Butts B, Gary RA, Dunbar SB, Butler J.
J Card Fail. 2015 Jul;21(7):586-93. doi: 10.1016/j.cardfail.2015.04.014. Epub 2015 May 14. Review.

Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes.
Lee HJ, Hong YS, Jun W, Yang SJ.
J Med Food. 2015 Nov;18(11):1207-13. doi: 10.1089/jmf.2015.3439. Epub 2015 May 14.

Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome.
Liu W, Zhang X, Zhao M, Zhang X, Chi J, Liu Y, Lin F, Fu Y, Ma D, Yin X.
Cell Physiol Biochem. 2015;35(6):2483-500. doi: 10.1159/000374048. Epub 2015 Apr 24.

NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins.
Altaf A, Qu P, Zhao Y, Wang H, Lou D, Niu N.
Coron Artery Dis. 2015 Aug;26(5):409-21. doi: 10.1097/MCA.0000000000000255.

CD36/SR-B2-TLR2 Dependent Pathways Enhance Porphyromonas gingivalis Mediated Atherosclerosis in the Ldlr KO Mouse Model.
Brown PM, Kennedy DJ, Morton RE, Febbraio M.
PLoS One. 2015 May 4;10(5):e0125126. doi: 10.1371/journal.pone.0125126. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0130245

Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse.
Marchetti C, Toldo S, Chojnacki J, Mezzaroma E, Liu K, Salloum FN, Nordio A, Carbone S, Mauro AG, Das A, Zalavadia AA, Halquist MS, Federici M, Van Tassell BW, Zhang S, Abbate A.
J Cardiovasc Pharmacol. 2015 Jul;66(1):1-8. doi: 10.1097/FJC.0000000000000247.

Sudden cardiac arrest secondary to cardiac amyloidosis in a young woman with cryopyrin-associated periodic syndrome.
Endo K, Suzuki A, Sato K, Shiga T.
BMJ Case Rep. 2015 Apr 16;2015. pii: bcr2015209468. doi: 10.1136/bcr-2015-209468.

Drivers of age-related inflammation and strategies for healthspan extension.
Goldberg EL, Dixit VD.
Immunol Rev. 2015 May;265(1):63-74. doi: 10.1111/imr.12295. Review.

Oral Infections, Metabolic Inflammation, Genetics, and Cardiometabolic Diseases.
Janket SJ, Javaheri H, Ackerson LK, Ayilavarapu S, Meurman JH.
J Dent Res. 2015 Sep;94(9 Suppl):119S-27S. doi: 10.1177/0022034515580795. Epub 2015 Apr 3. Review.

Resveratrol alleviates vascular inflammatory injury by inhibiting inflammasome activation in rats with hypercholesterolemia and vitamin D2 treatment.
Deng ZY, Hu MM, Xin YF, Gang C.
Inflamm Res. 2015 May;64(5):321-32. doi: 10.1007/s00011-015-0810-4. Epub 2015 Apr 2.

FGF-21 alleviates diabetes-associated vascular complications: Inhibiting NF-κB/NLRP3inflammasome-mediated inflammation?
Liu MH.
Int J Cardiol. 2015 Apr 15;185:320-1. doi: 10.1016/j.ijcard.2015.03.165. Epub 2015 Mar 17. No abstract available. 

Metabolic signals and innate immune activation in obesity and exercise.
Ringseis R, Eder K, Mooren FC, Krüger K.
Exerc Immunol Rev. 2015;21:58-68. Review.

Increased Expression of NLRP3 Inflammasome in Wall of Ruptured and Unruptured Human Cerebral Aneurysms: Preliminary Results.
Zhang D, Yan H, Hu Y, Zhuang Z, Yu Z, Hang C.
J Stroke Cerebrovasc Dis. 2015 May;24(5):972-9. doi: 10.1016/j.jstrokecerebrovasdis.2014.12.019. Epub 2015 Mar 23.

Activation of TLR3 induces osteogenic responses in human aortic valve interstitial cells through the NF-κB and ERK1/2 pathways.

Zhan Q, Song R, Zeng Q, Yao Q, Ao L, Xu D, Fullerton DA, Meng X.

Int J Biol Sci. 2015 Mar 20;11(4):482-93. doi: 10.7150/ijbs.10905. eCollection 2015.

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK.
Li Y, Li J, Li S, Li Y, Wang X, Liu B, Fu Q, Ma S.
Toxicol Appl Pharmacol. 2015 Jul 1;286(1):53-63. doi: 10.1016/j.taap.2015.03.010. Epub 2015 Mar 16.

Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease.
Mediators Inflamm. 2015;2015:846782. doi: 10.1155/2015/846782. Epub 2015 Feb 18. Review.

Cardiovascular pathobiology of inflammasomes: inflammatory machinery and beyond.
Li PL.
Antioxid Redox Signal. 2015 May 1;22(13):1079-83. doi: 10.1089/ars.2015.6319. Epub 2015 Apr 1.

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.
Denes A, Coutts G, Lénárt N, Cruickshank SM, Pelegrin P, Skinner J, Rothwell N, Allan SM, Brough D.
Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4050-5. doi: 10.1073/pnas.1419090112. Epub 2015 Mar 16.

P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation.
Peng K, Liu L, Wei D, Lv Y, Wang G, Xiong W, Wang X, Altaf A, Wang L, He D, Wang H, Qu P.
Int J Mol Med. 2015 May;35(5):1179-88. doi: 10.3892/ijmm.2015.2129. Epub 2015 Mar 9.

Aggregatibacter actinomycetemcomitans induces Th17 cells in atherosclerotic lesions.
Jia R, Hashizume-Takizawa T, Du Y, Yamamoto M, Kurita-Ochiai T.
Pathog Dis. 2015 Apr;73(3). pii: ftu027. doi: 10.1093/femspd/ftu027. Epub 2015 Jan 28.

Taming the inflammasome.
Levy M, Thaiss CA, Elinav E.
Nat Med. 2015 Mar;21(3):213-5. doi: 10.1038/nm.3808. No abstract available. 

MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage.
Yang Z, Zhong L, Xian R, Yuan B.
Mol Immunol. 2015 Jun;65(2):267-76. doi: 10.1016/j.molimm.2014.12.018. Epub 2015 Feb 21.

Role of extracellular histones in the cardiomyopathy of sepsis.
Kalbitz M, Grailer JJ, Fattahi F, Jajou L, Herron TJ, Campbell KF, Zetoune FS, Bosmann M, Sarma JV, Huber-Lang M, Gebhard F, Loaiza R, Valdivia HH, Jalife J, Russell MW, Ward PA.
FASEB J. 2015 May;29(5):2185-93. doi: 10.1096/fj.14-268730. Epub 2015 Feb 13.

Macrophage inflammasome mediates hyperhomocysteinemia-aggravated abdominal aortic aneurysm.
Sun W, Pang Y, Liu Z, Sun L, Liu B, Xu M, Dong Y, Feng J, Jiang C, Kong W, Wang X.
J Mol Cell Cardiol. 2015 Apr;81:96-106. doi: 10.1016/j.yjmcc.2015.02.005. Epub 2015 Feb 11.

ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1β-dependent manner.
Symington JW, Wang C, Twentyman J, Owusu-Boaitey N, Schwendener R, Núñez G, Schilling JD, Mysorekar IU.
Mucosal Immunol. 2015 Nov;8(6):1388-99. doi: 10.1038/mi.2015.7. Epub 2015 Feb 11.

Activation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated atherosclerosis.
Yamaguchi Y, Kurita-Ochiai T, Kobayashi R, Suzuki T, Ando T.
Pathog Dis. 2015 Jun;73(4). pii: ftv011. doi: 10.1093/femspd/ftv011. Epub 2015 Feb 6.

NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.
Abderrazak A, Syrovets T, Couchie D, El Hadri K, Friguet B, Simmet T, Rouis M.
Redox Biol. 2015;4:296-307. doi: 10.1016/j.redox.2015.01.008. Epub 2015 Jan 14. Review.

Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet.
Abderrazak A, Couchie D, Mahmood DF, Elhage R, Vindis C, Laffargue M, Matéo V, Büchele B, Ayala MR, El Gaafary M, Syrovets T, Slimane MN, Friguet B, Fulop T, Simmet T, El Hadri K, Rouis M.
Circulation. 2015 Mar 24;131(12):1061-70. doi: 10.1161/CIRCULATIONAHA.114.013730. Epub 2015 Jan 22.

Protective effect of telmisartan on neurovascular unit and inflammasome in stroke-resistant spontaneously hypertensive rats.
Liu W, Yamashita T, Kurata T, Kono S, Hishikawa N, Deguchi K, Zhai Y, Abe K.
Neurol Res. 2015 Jun;37(6):491-501. doi: 10.1179/1743132815Y.0000000002. Epub 2015 Jan 16.

Cofactor-independent antiphospholipid antibodies activate the NLRP3-inflammasome via endosomal NADPH-oxidase: implications for the antiphospholipid syndrome.
Müller-Calleja N, Köhler A, Siebald B, Canisius A, Orning C, Radsak M, Stein P, Mönnikes R, Lackner KJ.
Thromb Haemost. 2015 May;113(5):1071-83. doi: 10.1160/TH14-07-0628. Epub 2015 Jan 15.

Urticarial vasculitis and urticarial autoinflammatory syndromes.
Marzano AV, Tavecchio S, Venturini M, Sala R, Calzavara-Pinton P, Gattorno M.
G Ital Dermatol Venereol. 2015 Feb;150(1):41-50. Epub 2015 Jan 14. Review.

Oxygen-glucose deprivation inducing B1 RNA inhibits neuronal cells metabolic activity by NLRP3 and associated proinflammatory cytokines production.
Wang L, Wang W, Zhang L, Dai P, Wang K, Hui H, Rao W, Peng C, Yang J, Yan Z, Fei Z.
Neurosci Lett. 2015 Feb 19;588:147-53. doi: 10.1016/j.neulet.2014.12.045. Epub 2014 Dec 24.

Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation.
Patel MN, Bernard WG, Milev NB, Cawthorn WP, Figg N, Hart D, Prieur X, Virtue S, Hegyi K, Bonnafous S, Bailly-Maitre B, Chu Y, Griffin JL, Mallat Z, Considine RV, Tran A, Gual P, Takeuchi O, Akira S, Vidal-Puig A, Bennett MR, Sethi JK.
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):506-11. doi: 10.1073/pnas.1414536112. Epub 2014 Dec 24.

Neurovascular protection by telmisartan via reducing neuroinflammation in stroke-resistant spontaneously hypertensive rat brain after ischemic stroke.
Kono S, Kurata T, Sato K, Omote Y, Hishikawa N, Yamashita T, Deguchi K, Abe K.
J Stroke Cerebrovasc Dis. 2015 Mar;24(3):537-47. doi: 10.1016/j.jstrokecerebrovasdis.2014.09.037. Epub 2014 Dec 19.

Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.
Toldo S, Mezzaroma E, McGeough MD, Peña CA, Marchetti C, Sonnino C, Van Tassell BW, Salloum FN, Voelkel NF, Hoffman HM, Abbate A.
Cardiovasc Res. 2015 Feb 1;105(2):203-12. doi: 10.1093/cvr/cvu259. Epub 2014 Dec 18.

Cutting edge: IL-1α is a crucial danger signal triggering acute myocardial inflammation during myocardial infarction.
Lugrin J, Parapanov R, Rosenblatt-Velin N, Rignault-Clerc S, Feihl F, Waeber B, Müller O, Vergely C, Zeller M, Tardivel A, Schneider P, Pacher P, Liaudet L.
J Immunol. 2015 Jan 15;194(2):499-503. doi: 10.4049/jimmunol.1401948. Epub 2014 Dec 10.

Nlrp3 plays no role in acute cardiac infarction due to low cardiac expression.
Jong WM, Leemans JC, Weber NC, Juffermans NP, Schultz MJ, Hollmann MW, Zuurbier CJ.
Int J Cardiol. 2014 Nov 15;177(1):41-3. doi: 10.1016/j.ijcard.2014.09.148. Epub 2014 Oct 10. No abstract available. 

TLR4 and NALP3 inflammasome in the development of endothelial dysfunction in uraemia.
Martin-Rodriguez S, Caballo C, Gutierrez G, Vera M, Cruzado JM, Cases A, Escolar G, Diaz-Ricart M.
Eur J Clin Invest. 2015 Feb;45(2):160-9. doi: 10.1111/eci.12392. Epub 2015 Jan 7.

Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis.
Chen Y, Li X, Boini KM, Pitzer AL, Gulbins E, Zhang Y, Li PL.
Biochim Biophys Acta. 2015 Feb;1853(2):396-408. doi: 10.1016/j.bbamcr.2014.11.012. Epub 2014 Nov 15.

Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells.
Yang H, Xiao L, Yuan Y, Luo X, Jiang M, Ni J, Wang N.
Biochem Pharmacol. 2014 Dec 15;92(4):599-606. doi: 10.1016/j.bcp.2014.10.001. Epub 2014 Oct 23.

Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.
Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H, Tsutsui H, Noda T, Sagara J, Taniguchi S, Takahashi M.
Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):127-36. doi: 10.1161/ATVBAHA.114.303763. Epub 2014 Nov 6.

Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion.
Kim HY, Kim SJ, Lee SM.
FEBS J. 2015 Jan;282(2):259-70. doi: 10.1111/febs.13123. Epub 2014 Nov 14.

Natural compounds and aging: between autophagy and inflammasome.
Chuang SY, Lin CH, Fang JY.
Biomed Res Int. 2014;2014:297293. doi: 10.1155/2014/297293. Epub 2014 Sep 14. Review.

Hierarchical regulation of wound healing by NOD-like receptors in cardiovascular disease.
Bracey NA, Duff HJ, Muruve DA.
Antioxid Redox Signal. 2015 May 1;22(13):1176-87. doi: 10.1089/ars.2014.6125. Epub 2014 Nov 10. Review.

Losartan inhibits LPS + ATP-induced IL-1beta secretion from mouse primary macrophages by suppressing NALP3 inflammasome.
Wang F, Huang L, Peng ZZ, Tang YT, Lu MM, Peng Y, Mel WJ, Wu L, Mo ZH, Meng J, Tao LJ.
Pharmazie. 2014 Sep;69(9):680-4.

Involvement of NLRP3 inflammasome in CVB3-induced viral myocarditis.
Wang Y, Gao B, Xiong S.
Am J Physiol Heart Circ Physiol. 2014 Nov 15;307(10):H1438-47. doi: 10.1152/ajpheart.00441.2014. Epub 2014 Sep 26.

Cardiac fibroblasts contribute to myocardial dysfunction in mice with sepsis: the role of NLRP3inflammasome activation.
Zhang W, Xu X, Kao R, Mele T, Kvietys P, Martin CM, Rui T.
PLoS One. 2014 Sep 12;9(9):e107639. doi: 10.1371/journal.pone.0107639. eCollection 2014.

Endothelial dysfunction: the role of sterol regulatory element-binding protein-induced NOD-like receptor family pyrin domain-containing protein 3 inflammasome in atherosclerosis.
Chen Z, Martin M, Li Z, Shyy JY.
Curr Opin Lipidol. 2014 Oct;25(5):339-49. doi: 10.1097/MOL.0000000000000107. Review.

Moderate hypoxia potentiates interleukin-1β production in activated human macrophages.
Folco EJ, Sukhova GK, Quillard T, Libby P.
Circ Res. 2014 Oct 24;115(10):875-83. doi: 10.1161/CIRCRESAHA.115.304437. Epub 2014 Sep 2.

NLRP3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat model.

Luo B, Li B, Wang W, Liu X, Xia Y, Zhang C, Zhang M, Zhang Y, An F.
PLoS One. 2014 Aug 19;9(8):e104771. doi: 10.1371/journal.pone.0104771. eCollection 2014.

LOX-1 and mitochondria: an inflammatory relationship.
Christ A, Latz E.
Cardiovasc Res. 2014 Sep 1;103(4):435-7. doi: 10.1093/cvr/cvu187. Epub 2014 Aug 11. No abstract available. 

Retinal ischemia/reperfusion injury is mediated by Toll-like receptor 4 activation of NLRP3inflammasomes.
Qi Y, Zhao M, Bai Y, Huang L, Yu W, Bian Z, Zhao M, Li X.
Invest Ophthalmol Vis Sci. 2014 Aug 5;55(9):5466-75. doi: 10.1167/iovs.14-14380.

[Expression level of NLRP3 inflammasome and its clinical significance in multiple myeloma].
Li N, Li Z, Li D, Yan Z, Zhang Z, Chen L, Chen C, Pan X, Zeng L, Xu K.Zhonghua Xue Ye Xue Za Zhi.
2014 Jul;35(7):661-3. doi: 10.3760/cma.j.issn.0253-2727.2014.07.022. Chinese. No abstract available. 

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury.
Liu Y, Lian K, Zhang L, Wang R, Yi F, Gao C, Xin C, Zhu D, Li Y, Yan W, Xiong L, Gao E, Wang H, Tao L.
Basic Res Cardiol. 2014;109(5):415. doi: 10.1007/s00395-014-0415-z. Epub 2014 Jul 12.

Silence of NLRP3 suppresses atherosclerosis and stabilizes plaques in apolipoprotein E-deficient mice.
Zheng F, Xing S, Gong Z, Mu W, Xing Q.
Mediators Inflamm. 2014;2014:507208. doi: 10.1155/2014/507208. Epub 2014 Jun 4.

The inflammasome and lupus: another innate immune mechanism contributing to diseasepathogenesis?
Kahlenberg JM, Kaplan MJ.
Curr Opin Rheumatol. 2014 Sep;26(5):475-81. doi: 10.1097/BOR.0000000000000088. Review.

Reply to letter regarding article, “NLRP3 inflammasome as a therapeutic target in myocardial infarction”.
Takahashi M.
Int Heart J. 2014;55(4):380. Epub 2014 Jun 18. No abstract available. 

Letter by Mezzaroma, et al regarding article, “NLRP3 inflammasome as a therapeutic target in myocardial infarction”.
Mezzaroma E, Marchetti C, Toldo S.
Int Heart J. 2014;55(4):379. Epub 2014 Jun 18. No abstract available. 

Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice.
Ishrat T, Mohamed IN, Pillai B, Soliman S, Fouda AY, Ergul A, El-Remessy AB, Fagan SC.
Mol Neurobiol. 2015 Apr;51(2):766-78. doi: 10.1007/s12035-014-8766-x. Epub 2014 Jun 18. Erratum in: Mol Neurobiol. 2015 Apr;51(2):779-80

Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia/reperfusion in mice.
Zhang N, Zhang X, Liu X, Wang H, Xue J, Yu J, Kang N, Wang X.
Mediators Inflamm. 2014;2014:370530. doi: 10.1155/2014/370530. Epub 2014 Apr 29.

NLRP3, a potential therapeutic target for type 2 diabetes?
Liu SS, Ding Y, Lou JQ.
Cardiovasc Drugs Ther. 2014 Aug;28(4):391-2. doi: 10.1007/s10557-014-6531-z. No abstract available. 

Anti-inflammatory therapies for cardiovascular disease.
Ridker PM, Lüscher TF.
Eur Heart J. 2014 Jul 14;35(27):1782-91. doi: 10.1093/eurheartj/ehu203. Epub 2014 May 26. Review.

Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome.
Bracey NA, Gershkovich B, Chun J, Vilaysane A, Meijndert HC, Wright JR Jr, Fedak PW, Beck PL, Muruve DA, Duff HJ.
J Biol Chem. 2014 Jul 11;289(28):19571-84. doi: 10.1074/jbc.M114.550624. Epub 2014 May 19.

A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion.
Bakker PJ, Butter LM, Claessen N, Teske GJ, Sutterwala FS, Florquin S, Leemans JC.
Am J Pathol. 2014 Jul;184(7):2013-22. doi: 10.1016/j.ajpath.2014.04.005. Epub 2014 May 11.

Early progression of atherosclerosis in children with chronic infantile neurological cutaneous and articular syndrome.
Yamamura K, Takada H, Uike K, Nakashima Y, Hirata Y, Nagata H, Takimoto T, Ishimura M, Morihana E, Ohga S, Hara T.
Rheumatology (Oxford). 2014 Oct;53(10):1783-7. doi: 10.1093/rheumatology/keu180. Epub 2014 May 11.

Intermittent fasting attenuates inflammasome activity in ischemic stroke.
Fann DY, Santro T, Manzanero S, Widiapradja A, Cheng YL, Lee SY, Chunduri P, Jo DG, Stranahan AM, Mattson MP, Arumugam TV.
Exp Neurol. 2014 Jul;257:114-9. doi: 10.1016/j.expneurol.2014.04.017. Epub 2014 May 5.

Reactive oxygen species and NLRP3 inflammasome activation.
Li J, Yan F, Chen G.
Ann Neurol. 2014 Jun;75(6):972. doi: 10.1002/ana.24173. Epub 2014 May 28. No abstract available. 

LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis.
Ding Z, Liu S, Wang X, Dai Y, Khaidakov M, Deng X, Fan Y, Xiang D, Mehta JL.
Cardiovasc Res. 2014 Sep 1;103(4):619-28. doi: 10.1093/cvr/cvu114. Epub 2014 Apr 28.

Extracellular histones in tissue injury and inflammation.
Allam R, Kumar SV, Darisipudi MN, Anders HJ.
J Mol Med (Berl). 2014 May;92(5):465-72. doi: 10.1007/s00109-014-1148-z. Epub 2014 Apr 6. Review.

NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.
Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M.
J Immunol. 2014 May 1;192(9):4342-51. doi: 10.4049/jimmunol.1302039. Epub 2014 Apr 2.

Molecule 16673-34-0: a new tool in our arsenal against inflammation.
Lipinski MJ, Frias JC.
J Cardiovasc Pharmacol. 2014 Apr;63(4):314-5. doi: 10.1097/FJC.0000000000000070.

Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans.
Ellis J, Lange EM, Li J, Dupuis J, Baumert J, Walston JD, Keating BJ, Durda P, Fox ER, Palmer CD, Meng YA, Young T, Farlow DN, Schnabel RB, Marzi CS, Larkin E, Martin LW, Bis JC, Auer P, Ramachandran VS, Gabriel SB, Willis MS, Pankow JS, Papanicolaou GJ, Rotter JI, Ballantyne CM, Gross MD, Lettre G, Wilson JG, Peters U, Koenig W, Tracy RP, Redline S, Reiner AP, Benjamin EJ, Lange LA.
Hum Genet. 2014 Aug;133(8):985-95. doi: 10.1007/s00439-014-1439-z. Epub 2014 Mar 19.

AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease.
Steinberg GR, Schertzer JD.
Immunol Cell Biol. 2014 Apr;92(4):340-5. doi: 10.1038/icb.2014.11. Epub 2014 Mar 18. Review.

NLRP3 inflammasome as a novel player in myocardial infarction.
Takahashi M.
Int Heart J. 2014;55(2):101-5. Epub 2014 Mar 14. Review.

Lysosomes integrate metabolic-inflammatory cross-talk in primary macrophage inflammasome activation.
Weber K, Schilling JD.
J Biol Chem. 2014 Mar 28;289(13):9158-71. doi: 10.1074/jbc.M113.531202. Epub 2014 Feb 15.

Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis.
Li X, Zhang Y, Xia M, Gulbins E, Boini KM, Li PL.
PLoS One. 2014 Jan 27;9(1):e87552. doi: 10.1371/journal.pone.0087552. eCollection 2014.

NLRP1 inflammasome, and not NLRP3, is the key in the shift to proinflammatory state on endothelial cells in peripheral arterial disease.
Bleda S, de Haro J, Varela C, Esparza L, Ferruelo A, Acin F.
Int J Cardiol. 2014 Mar 15;172(2):e282-4. doi: 10.1016/j.ijcard.2013.12.201. Epub 2014 Jan 9. No abstract available. 

NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke.
Yang F, Wang Z, Wei X, Han H, Meng X, Zhang Y, Shi W, Li F, Xin T, Pang Q, Yi F.
J Cereb Blood Flow Metab. 2014 Apr;34(4):660-7. doi: 10.1038/jcbfm.2013.242. Epub 2014 Jan 15.

A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse.
Marchetti C, Chojnacki J, Toldo S, Mezzaroma E, Tranchida N, Rose SW, Federici M, Van Tassell BW, Zhang S, Abbate A.
J Cardiovasc Pharmacol. 2014 Apr;63(4):316-322. doi: 10.1097/FJC.0000000000000053.

Deregulated NLRP3 and NLRP1 inflammasomes and their correlations with disease activity in systemic lupus erythematosus.
Yang Q, Yu C, Yang Z, Wei Q, Mu K, Zhang Y, Zhao W, Wang X, Huai W, Han L.
J Rheumatol. 2014 Mar;41(3):444-52. doi: 10.3899/jrheum.130310. Epub 2013 Dec 15.

Glibenclamide improves kidney and heart structure and function in the adenine-diet model of chronic kidney disease.
Diwan V, Gobe G, Brown L.
Pharmacol Res. 2014 Jan;79:104-10. doi: 10.1016/j.phrs.2013.11.007. Epub 2013 Nov 27.

Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury.
El-Azab MF, Baldowski BR, Mysona BA, Shanab AY, Mohamed IN, Abdelsaid MA, Matragoon S, Bollinger KE, Saul A, El-Remessy AB.
Br J Pharmacol. 2014 Mar;171(5):1299-313. doi: 10.1111/bph.12535.

Treating inflammation by blocking interleukin-1 in humans.
Dinarello CA, van der Meer JW.
Semin Immunol. 2013 Dec 15;25(6):469-84. doi: 10.1016/j.smim.2013.10.008. Epub 2013 Nov 23. Review.

NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage.
Ma Q, Chen S, Hu Q, Feng H, Zhang JH, Tang J.
Ann Neurol. 2014 Feb;75(2):209-19. doi: 10.1002/ana.24070. Epub 2014 Jan 2.

Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model.
Luo B, Li B, Wang W, Liu X, Liu X, Xia Y, Zhang C, Zhang Y, Zhang M, An F.
Cardiovasc Drugs Ther. 2014 Feb;28(1):33-43. doi: 10.1007/s10557-013-6498-1.

Ethanol inhibits activation of NLRP3 and AIM2 inflammasomes in human macrophages–a novel anti-inflammatory action of alcohol.
Nurmi K, Virkanen J, Rajamäki K, Niemi K, Kovanen PT, Eklund KK.
PLoS One. 2013 Nov 11;8(11):e78537. doi: 10.1371/journal.pone.0078537. eCollection 2013.

The NLRP3 inflammasome and diabetic cardiomyopathy : editorial to: “Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model” by Beibei Luo et al.
Singh LP.
Cardiovasc Drugs Ther. 2014 Feb;28(1):5-6. doi: 10.1007/s10557-013-6501-x. No abstract available. 

Molecular mechanisms of crystal-related kidney inflammation and injury. Implications for cholesterol embolism, crystalline nephropathies and kidney stone disease.
Mulay SR, Evan A, Anders HJ.
Nephrol Dial Transplant. 2014 Mar;29(3):507-14. doi: 10.1093/ndt/gft248. Epub 2013 Oct 25.

Novel NLRP3/cryopyrin mutations and pro-inflammatory cytokine profiles in Behçet’s syndrome patients.
Yüksel Ş, Eren E, Hatemi G, Sahillioğlu AC, Gültekin Y, Demiröz D, Akdiş C, Fresko İ, Özören N.
Int Immunol. 2014 Feb;26(2):71-81. doi: 10.1093/intimm/dxt046. Epub 2013 Oct 17.

Pathogenesis of acute stroke and the role of inflammasomes.
Fann DY, Lee SY, Manzanero S, Chunduri P, Sobey CG, Arumugam TV.
Ageing Res Rev. 2013 Sep;12(4):941-66. doi: 10.1016/j.arr.2013.09.004. Epub 2013 Oct 5. Review.

CD36: linking lipids to the NLRP3 inflammasome, atherogenesis and atherothrombosis.
Oury C.
Cell Mol Immunol. 2014 Jan;11(1):8-10. doi: 10.1038/cmi.2013.48. Epub 2013 Oct 7. No abstract available. 

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke.
Fann DY, Lee SY, Manzanero S, Tang SC, Gelderblom M, Chunduri P, Bernreuther C, Glatzel M, Cheng YL, Thundyil J, Widiapradja A, Lok KZ, Foo SL, Wang YC, Li YI, Drummond GR, Basta M, Magnus T, Jo DG, Mattson MP, Sobey CG, Arumugam TV.
Cell Death Dis. 2013 Sep 5;4:e790. doi: 10.1038/cddis.2013.326.

NLRP3 inflammasome activation in coronary artery disease: results from prospective and randomized study of treatment with atorvastatin or rosuvastatin.
Satoh M, Tabuchi T, Itoh T, Nakamura M.
Clin Sci (Lond). 2014 Feb;126(3):233-41. doi: 10.1042/CS20130043.

Neuroendocrine and cardiac metabolic dysfunction and NLRP3 inflammasome activation in adipose tissue and pancreas following chronic spinal cord injury in the mouse.
Bigford GE, Bracchi-Ricard VC, Keane RW, Nash MS, Bethea JR.
ASN Neuro. 2013 Sep 4;5(4):243-55. doi: 10.1042/AN20130021.

Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury.
Huang H, Chen HW, Evankovich J, Yan W, Rosborough BR, Nace GW, Ding Q, Loughran P, Beer-Stolz D, Billiar TR, Esmon CT, Tsung A.
J Immunol. 2013 Sep 1;191(5):2665-79. doi: 10.4049/jimmunol.1202733. Epub 2013 Jul 31.

Closing the loop on inflammation and atherothrombosis: why perform the CIRT and CANTOS trials?
Ridker PM.
Trans Am Clin Climatol Assoc. 2013;124:174-90.

NLRP3 inflammasome activation: CD36 serves double duty.
Kagan JC, Horng T.
Nat Immunol. 2013 Aug;14(8):772-4. doi: 10.1038/ni.2668. No abstract available. 

Pirfenidone attenuates cardiac fibrosis in a mouse model of TAC-induced left ventricular remodeling by suppressing NLRP3 inflammasome formation.
Wang Y, Wu Y, Chen J, Zhao S, Li H.
Cardiology. 2013;126(1):1-11. doi: 10.1159/000351179. Epub 2013 Jul 2.

Atheroprone flow activation of the sterol regulatory element binding protein 2 and nod-like receptor protein 3 inflammasome mediates focal atherosclerosis.
Abe J, Berk BC.
Circulation. 2013 Aug 6;128(6):579-82. doi: 10.1161/CIRCULATIONAHA.113.004390. Epub 2013 Jul 9. No abstract available. 

Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility.
Xiao H, Lu M, Lin TY, Chen Z, Chen G, Wang WC, Marin T, Shentu TP, Wen L, Gongol B, Sun W, Liang X, Chen J, Huang HD, Pedra JH, Johnson DA, Shyy JY.
Circulation. 2013 Aug 6;128(6):632-42. doi: 10.1161/CIRCULATIONAHA.113.002714. Epub 2013 Jul 9.

Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs.
Li Y, Xu S, Jiang B, Cohen RA, Zang M.
PLoS One. 2013 Jun 25;8(6):e67532. doi: 10.1371/journal.pone.0067532. Print 2013.

P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH.
Chen S, Ma Q, Krafft PR, Hu Q, Rolland W 2nd, Sherchan P, Zhang J, Tang J, Zhang JH.
Neurobiol Dis. 2013 Oct;58:296-307. doi: 10.1016/j.nbd.2013.06.011. Epub 2013 Jun 29.

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA, Moore KJ.
Nat Immunol. 2013 Aug;14(8):812-20. doi: 10.1038/ni.2639. Epub 2013 Jun 30.

NLRP3 in myocardial ischaemia-reperfusion injury: inflammasome-dependent or -independent role in different cell types.
Takahashi M.
Cardiovasc Res. 2013 Jul 1;99(1):4-5. Epub 2013 Jun 3. No abstract available. 

Cathepsin B inhibition attenuates cardiac dysfunction and remodeling following myocardial infarction by inhibiting the NLRP3 pathway.
Liu A, Gao X, Zhang Q, Cui L.
Mol Med Rep. 2013 Aug;8(2):361-6. doi: 10.3892/mmr.2013.1507. Epub 2013 Jun 4.

Gene set enrichment analysis identifies key innate immune pathways in primary graft dysfunction after lung transplantation.
Cantu E, Lederer DJ, Meyer K, Milewski K, Suzuki Y, Shah RJ, Diamond JM, Meyer NJ, Tobias JW, Baldwin DA, Van Deerlin VM, Olthoff KM, Shaked A, Christie JD; CTOT Investigators.
Am J Transplant. 2013 Jul;13(7):1898-904. doi: 10.1111/ajt.12283. Epub 2013 May 24.

A role for NLRP3 inflammasome in acute myocardial ischaemia-reperfusion injury? Reply.
Sandanger Ø, Ranheim T, Vinge LE, Bliksøen M, Valen G, Aukrust P, Yndestad A.
Cardiovasc Res. 2013 Jul 1;99(1):226-7. doi: 10.1093/cvr/cvt130. Epub 2013 May 25. No abstract available. 

A role for NLRP3 inflammasome in acute myocardial ischaemia-reperfusion injury?
Jong WM, Zuurbier CJ.
Cardiovasc Res. 2013 Jul 1;99(1):226. doi: 10.1093/cvr/cvt120. Epub 2013 May 22. No abstract available. 

Role of NLRP3 (cryopyrin) in acute myocardial infarction.
Mezzaroma E, Toldo S, Abbate A.
Cardiovasc Res. 2013 Jul 1;99(1):225-6. doi: 10.1093/cvr/cvt123. Epub 2013 May 21. No abstract available. 

Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behçet disease.
Kirino Y, Zhou Q, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Özyazgan Y, Ugurlu S, Erer B, Abaci N, Ustek D, Meguro A, Ueda A, Takeno M, Inoko H, Ombrello MJ, Satorius CL, Maskeri B, Mullikin JC, Sun HW, Gutierrez-Cruz G, Kim Y, Wilson AF, Kastner DL, Gül A, Remmers EF.
Proc Natl Acad Sci U S A. 2013 May 14;110(20):8134-9. doi: 10.1073/pnas.1306352110. Epub 2013 Apr 30.

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Sandanger Ø, Ranheim T, Vinge LE, Bliksøen M, Alfsnes K, Finsen AV, Dahl CP, Askevold ET, Florholmen G, Christensen G, Fitzgerald KA, Lien E, Valen G, Espevik T, Aukrust P, Yndestad A.
Cardiovasc Res. 2013 Jul 1;99(1):164-74. doi: 10.1093/cvr/cvt091. Epub 2013 Apr 10.

Release of IL-1 β triggered by Milan summer PM10: molecular pathways involved in the cytokine release.
Bengalli R, Molteni E, Longhin E, Refsnes M, Camatini M, Gualtieri M.
Biomed Res Int. 2013;2013:158093. doi: 10.1155/2013/158093. Epub 2013 Feb 6.

Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis.
Shimabukuro M, Hirata Y, Tabata M, Dagvasumberel M, Sato H, Kurobe H, Fukuda D, Soeki T, Kitagawa T, Takanashi S, Sata M.
Arterioscler Thromb Vasc Biol. 2013 May;33(5):1077-84. doi: 10.1161/ATVBAHA.112.300829. Epub 2013 Mar 7.

NLRP3 inflammasomes show high expression in aorta of patients with atherosclerosis.
Zheng F, Xing S, Gong Z, Xing Q.
Heart Lung Circ. 2013 Sep;22(9):746-50. doi: 10.1016/j.hlc.2013.01.012. Epub 2013 Feb 23.

Nalp3 inflammasome is activated and required for vascular smooth muscle cell calcification.
Wen C, Yang X, Yan Z, Zhao M, Yue X, Cheng X, Zheng Z, Guan K, Dou J, Xu T, Zhang Y, Song T, Wei C, Zhong H.
Int J Cardiol. 2013 Oct 3;168(3):2242-7. doi: 10.1016/j.ijcard.2013.01.211. Epub 2013 Feb 27.

Cholesterol crystals and inflammation.
Grebe A, Latz E.
Curr Rheumatol Rep. 2013 Mar;15(3):313. doi: 10.1007/s11926-012-0313-z. Review.

A novel mechanism of NALP3 inducing ischemia reperfusion injury by activating MAPK pathway in acute renal failure.
Hao JL, Li YF, Li RS.
Med Hypotheses. 2013 Apr;80(4):463-5. doi: 10.1016/j.mehy.2012.12.041. Epub 2013 Feb 8.

Association of nucleotide-binding oligomerization domain-like receptor 3 inflammasome and adverse clinical outcomes in patients with idiopathic dilated cardiomyopathy.
Luo B, Wang F, Li B, Dong Z, Liu X, Zhang C, An F.
Clin Chem Lab Med. 2013 Jul;51(7):1521-8. doi: 10.1515/cclm-2012-0600.

The heart on fire: inflammasome and cardiomyopathy.
Abbate A.
Exp Physiol. 2013 Feb;98(2):385. doi: 10.1113/expphysiol.2012.069021. No abstract available. 

Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis.
Cronstein BN, Sunkureddi P.
J Clin Rheumatol. 2013 Jan;19(1):19-29. doi: 10.1097/RHU.0b013e31827d8790. Review.

Specific inflammasomes in complex diseases.
Masters SL.
Clin Immunol. 2013 Jun;147(3):223-8. doi: 10.1016/j.clim.2012.12.006. Epub 2012 Dec 21. Review.

Inflammasomes: sensors of metabolic stresses for vascular inflammation.
Yin Y, Pastrana JL, Li X, Huang X, Mallilankaraman K, Choi ET, Madesh M, Wang H, Yang XF.
Front Biosci (Landmark Ed). 2013 Jan 1;18:638-49. Review.

IL-1β triggered by peptidoglycan and lipopolysaccharide through TLR2/4 and ROS-NLRP3inflammasome-dependent pathways is involved in ocular Behçet’s disease.
Liang L, Tan X, Zhou Q, Zhu Y, Tian Y, Yu H, Kijlstra A, Yang P.
Invest Ophthalmol Vis Sci. 2013 Jan 14;54(1):402-14. doi: 10.1167/iovs.12-11047.

Reduced expression of NLRP3 and MEFV in human ischemic heart tissue.
Hermansson C, Lundqvist A, Wasslavik C, Palmqvist L, Jeppsson A, Hultén LM.
Biochem Biophys Res Commun. 2013 Jan 4;430(1):425-8. doi: 10.1016/j.bbrc.2012.11.070. Epub 2012 Dec 1.

Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse.
Toldo S, Mezzaroma E, Van Tassell BW, Farkas D, Marchetti C, Voelkel NF, Abbate A.
Exp Physiol. 2013 Mar;98(3):734-45. doi: 10.1113/expphysiol.2012.069831. Epub 2012 Nov 23.

Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.
Vajjhala PR, Mirams RE, Hill JM.
J Biol Chem. 2012 Dec 7;287(50):41732-43. doi: 10.1074/jbc.M112.381228. Epub 2012 Oct 12.

The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β.
Bracey NA, Beck PL, Muruve DA, Hirota SA, Guo J, Jabagi H, Wright JR Jr, Macdonald JA, Lees-Miller JP, Roach D, Semeniuk LM, Duff HJ.
Exp Physiol. 2013 Feb;98(2):462-72. doi: 10.1113/expphysiol.2012.068338. Epub 2012 Jul 30.

Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation.
Jiang Y, Wang M, Huang K, Zhang Z, Shao N, Zhang Y, Wang W, Wang S.
Biochem Biophys Res Commun. 2012 Aug 24;425(2):121-6. doi: 10.1016/j.bbrc.2012.07.011. Epub 2012 Jul 13.

Monosodium urate (MSU) crystals increase gout associated coronary heart disease (CHD) risk through the activation of NLRP3 inflammasome.
Int J Cardiol. 2012 Sep 20;160(1):72-3. doi: 10.1016/j.ijcard.2012.05.083. Epub 2012 Jun 20. No abstract available. 

Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases.
Salminen A, Ojala J, Kaarniranta K, Kauppinen A.
Cell Mol Life Sci. 2012 Sep;69(18):2999-3013. doi: 10.1007/s00018-012-0962-0. Epub 2012 Mar 25. Review.

Cholesterol, Inflammasomes, and Atherogenesis.
Ordovas-Montanes JM, Ordovas JM.
Curr Cardiovasc Risk Rep. 2012 Feb 1;6(1):45-52.

Interleukin-1β is crucial for the induction of coronary artery inflammation in a mouse model of Kawasaki disease.
Lee Y, Schulte DJ, Shimada K, Chen S, Crother TR, Chiba N, Fishbein MC, Lehman TJ, Arditi M.
Circulation. 2012 Mar 27;125(12):1542-50. doi: 10.1161/CIRCULATIONAHA.111.072769. Epub 2012 Feb 23.

[Update in interleukin-1 inhibition].
de Boysson H.
Rev Med Interne. 2012 Apr;33(4):235-7. doi: 10.1016/j.revmed.2012.01.012. Epub 2012 Feb 22. French. No abstract available. 

Inflammasomes in cardiovascular diseases.
Garg NJ.
Am J Cardiovasc Dis. 2011;1(3):244-54. Epub 2011 Sep 10.

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse.
Mezzaroma E, Toldo S, Farkas D, Seropian IM, Van Tassell BW, Salloum FN, Kannan HR, Menna AC, Voelkel NF, Abbate A.
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19725-30. doi: 10.1073/pnas.1108586108. Epub 2011 Nov 21.

Nucleotide-binding oligomerization domain-like receptors and inflammasomes in the pathogenesis of non-microbial inflammation and diseases.
Mason DR, Beck PL, Muruve DA.
J Innate Immun. 2012;4(1):16-30. doi: 10.1159/000334247. Epub 2011 Nov 4. Review.

Pulling down the plug on atherosclerosis: cooling down the inflammasome.
Hansson GK, Klareskog L.
Nat Med. 2011 Jul 7;17(7):790-1. doi: 10.1038/nm0711-790. No abstract available. 

[Cutaneous neutrophils infiltrates. Case 8. CINCA/NOMID syndrome].
Fraitag S.
Ann Pathol. 2011 Jun;31(3):203-7. doi: 10.1016/j.annpat.2011.05.005. Epub 2011 Jun 12. French. No abstract available. 

Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms.
Roberts RL, Van Rij AM, Phillips LV, Young S, McCormick SP, Merriman TR, Jones GT.
Atherosclerosis. 2011 Sep;218(1):123-6. doi: 10.1016/j.atherosclerosis.2011.04.043. Epub 2011 May 10.

Hypoxia and inflammation.
Wanderer AA.
N Engl J Med. 2011 May 19;364(20):1976; author reply 1977. doi: 10.1056/NEJMc1103019. No abstract available. 

Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway.
Niemi K, Teirilä L, Lappalainen J, Rajamäki K, Baumann MH, Öörni K, Wolff H, Kovanen PT, Matikainen S, Eklund KK.
J Immunol. 2011 Jun 1;186(11):6119-28. doi: 10.4049/jimmunol.1002843. Epub 2011 Apr 20.

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis.
Freigang S, Ampenberger F, Spohn G, Heer S, Shamshiev AT, Kisielow J, Hersberger M, Yamamoto M, Bachmann MF, Kopf M.
Eur J Immunol. 2011 Jul;41(7):2040-51. doi: 10.1002/eji.201041316. Epub 2011 Jun 8.

Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses.
Yu M, Levine SJ.
Cytokine Growth Factor Rev. 2011 Apr;22(2):63-72. doi: 10.1016/j.cytogfr.2011.02.001. Epub 2011 Apr 3. Review.

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome.
Menu P, Pellegrin M, Aubert JF, Bouzourene K, Tardivel A, Mazzolai L, Tschopp J.
Cell Death Dis. 2011 Mar 31;2:e137. doi: 10.1038/cddis.2011.18.

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
Dehghan A, et al.
Circulation. 2011 Feb 22;123(7):731-8. doi: 10.1161/CIRCULATIONAHA.110.948570. Epub 2011 Feb 7.

Proposed pathobiologic mechanisms of hypoxia-ischemia-reperfusion in corticosteroid-resistant neutrophilic asthma and consideration of interleukin 1 targeted therapy.
Wanderer AA.
Ann Allergy Asthma Immunol. 2011 Jan;106(1):69-72. doi: 10.1016/j.anai.2010.09.007. No abstract available. 

Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice.
Zhu P, Duan L, Chen J, Xiong A, Xu Q, Zhang H, Zheng F, Tan Z, Gong F, Fang M.
Hum Gene Ther. 2011 Jul;22(7):853-64. doi: 10.1089/hum.2010.145. Epub 2011 Mar 7.

Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe).
Wassel CL, Lange LA, Keating BJ, Taylor KC, Johnson AD, Palmer C, Ho LA, Smith NL, Lange EM, Li Y, Yang Q, Delaney JA, Tang W, Tofler G, Redline S, Taylor HA Jr, Wilson JG, Tracy RP, Jacobs DR Jr, Folsom AR, Green D, O’Donnell CJ, Reiner AP.
Blood. 2011 Jan 6;117(1):268-75. doi: 10.1182/blood-2010-06-289546. Epub 2010 Oct 26.

An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury.
Shigeoka AA, Mueller JL, Kambo A, Mathison JC, King AJ, Hall WF, Correia Jda S, Ulevitch RJ, Hoffman HM, McKay DB.
J Immunol. 2010 Nov 15;185(10):6277-85. doi: 10.4049/jimmunol.1002330. Epub 2010 Oct 20. Erratum in: J Immunol. 2011 Feb 1;186(3):1880. 

[Inflammasome and cardiovascular diseases].
Connat JL.
Ann Cardiol Angeiol (Paris). 2011 Feb;60(1):48-54. doi: 10.1016/j.ancard.2010.07.011. Epub 2010 Aug 5. Review. French. 

[Cold-induced urticaria and angioedema. Classification, diagnosis and therapy].
Krause K, Degener F, Altrichter S, Ardelean E, Kalogeromitros D, Magerl M, Metz M, Siebenhaar F, Weller K, Maurer M.
Hautarzt. 2010 Sep;61(9):743-9. doi: 10.1007/s00105-010-1932-9. German. 

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E.
Nature. 2010 Apr 29;464(7293):1357-61. doi: 10.1038/nature08938. Erratum in: Nature. 2010 Jul 29;466(7306):652. 

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.
 ers A, Basu S, Bis JC, Rudnicka AR, Kavousi M, Chen MH, Baumert J, Lowe GD, McKnight B, Tang W, de Maat M, Larson MG, Eyhermendy S, McArdle WL, Lumley T, Pankow JS, Hofman A, Massaro JM, Rivadeneira F, Kolz M, Taylor KD, van Duijn CM, Kathiresan S, Illig T, Aulchenko YS, Volcik KA, Johnson AD, Uitterlinden AG, Tofler GH, Gieger C; Wellcome Trust Case Control Consortium, Psaty BM, Couper DJ, Boerwinkle E, Koenig W, O’Donnell CJ, Witteman JC, Strachan DP, Smith NL, Folsom AR.
Circ Cardiovasc Genet. 2009 Apr;2(2):125-33. doi: 10.1161/CIRCGENETICS.108.825224.

Rationale for IL-1beta-targeted therapy to minimize hypoxic-ischemic encephalopathy.
Wanderer AA.
J Perinatol. 2009 Dec;29(12):785-7. doi: 10.1038/jp.2009.114. No abstract available. 

Interleukin-1beta targeted therapy in severe persistent asthma (SPA) and chronic obstructive pulmonary disease (COPD): proposed similarities between biphasic pathobiology of SPA/COPD and ischemia-reperfusion injury.
Wanderer AA.
Isr Med Assoc J. 2008 Dec;10(12):837-42.

Colchicine update: 2008.
Terkeltaub RA.
Semin Arthritis Rheum. 2009 Jun;38(6):411-9. doi: 10.1016/j.semarthrit.2008.08.006. Epub 2008 Oct 29. Review.

Autoinflammatory diseases: mimics of autoimmunity or part of its spectrum? Case presentation.
Kiss MH, Magalhães CS.
J Clin Immunol. 2008 May;28 Suppl 1:S84-9. doi: 10.1007/s10875-008-9179-2. Epub 2008 Mar 20. Review.

Autoinflammatory gene mutations in Behçet’s disease.
Koné-Paut I, Sanchez E, Le Quellec A, Manna R, Touitou I.
 Ann Rheum Dis. 2007 Jun;66(6):832-4. Epub 2007 Jan 9.

An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and is associated with essential hypertension.
Omi T, Kumada M, Kamesaki T, Okuda H, Munkhtulga L, Yanagisawa Y, Utsumi N, Gotoh T, Hata A, Soma M, Umemura S, Ogihara T, Takahashi N, Tabara Y, Shimada K, Mano H, Kajii E, Miki T, Iwamoto S.
Eur J Hum Genet. 2006 Dec;14(12):1295-305. Epub 2006 Jul 26.

Variant chronic infantile neurologic, cutaneous, articular syndrome due to a mutation within the leucine-rich repeat domain of CIAS1.
Frenkel J, van Kempen MJ, Kuis W, van Amstel HK.
Arthritis Rheum. 2004 Aug;50(8):2719-20. No abstract available. 

Periodic fever, mild arthralgias, and reversible moderate and severe organ inflammation associated with the V198M mutation in the CIAS1 gene in three German patients–expanding phenotype of CIAS1 related autoinflammatory syndrome.
Pörksen G, Lohse P, Rösen-Wolff A, Heyden S, Förster T, Wendisch J, Heubner G, Bernuth H, Sallmann S, Gahr M, Roesler J.
Eur J Haematol. 2004 Aug;73(2):123-7.