{"id":924,"date":"2020-04-09T20:42:54","date_gmt":"2020-04-09T20:42:54","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=924"},"modified":"2020-04-09T23:37:05","modified_gmt":"2020-04-09T23:37:05","slug":"lung-disease-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/lung-disease-and-nlrp3\/","title":{"rendered":"Lung Disease and NLRP3"},"content":{"rendered":"

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Lung Disease and NLRP3<\/span><\/strong><\/h4>\n

 <\/p>\n

Sphingosine signaling dysfunction in airway cells as a potential contributor to progression from protracted bacterial bronchitis to bronchiectasis in children.
<\/a>Hodge S, Macowan M, Liu H, Hamon R, Chen AC, Marchant JM,\u00a0Pizzutto<\/g>\u00a0SJ, Upham JW, Chang AB.
Pediatr Pulmonol. 2020 Mar 16.\u00a0doi<\/g>: 10.1002\/ppul.24728. [Epub ahead of print]<\/p>\n

Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1\/Nrf2 pathway and inhibiting the NF-\u03baB and\u00a0NLRP3\u00a0pathways in carrageenan-induced pleurisy.
<\/a>Gao Y, Lv X, Yang H, Peng L, Ci X.
Food Funct. 2020 Mar 1;11(3):2522-2534.\u00a0doi<\/g>: 10.1039\/c9fo01984g. Epub 2020 Mar 6.<\/p>\n

Apelin\/APJ system: an emerging therapeutic target for respiratory\u00a0diseases.
<\/a>Yan J, Wang A, Cao J, Chen L.
Cell Mol Life Sci. 2020 Mar 3.\u00a0doi<\/g>: 10.1007\/s00018-020-03461-7. [Epub ahead of print] Review<\/p>\n

Hydrogen Sulfide Attenuates Particulate Matter-Induced Emphysema and Airway Inflammation Through Nrf2-Dependent Manner.
<\/a>Jia G, Yu S, Sun W, Yang J, Wang Y, Qi Y, Chen Y.
Front Pharmacol. 2020 Feb 7;11:29. doi: 10.3389\/fphar.2020.00029. eCollection 2020.<\/p>\n

A COX-2\/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress.
<\/a>Zhang YF, Sun CC, Duan\u00a0JX<\/g>, Yang HH, Zhang CY, Xiong JB, Zhong WJ, Zu C, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX.
Biomed Pharmacother. 2020 Feb 27;126:109907. doi<\/g>: 10.1016\/j.biopha.2020.109907. [Epub ahead of print<\/p>\n

The protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of\u00a0NLRP3inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells.
<\/a>Jiao P, Li W, Shen L, Li Y, Yu L, Liu Z.
Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):687-694.\u00a0doi<\/g>: 10.1080\/21691401.2020.1730391.<\/p>\n

Apolipoprotein E negatively regulates murine allergic airway inflammation via suppressing the activation of\u00a0NLRP3\u00a0inflammasome and oxidative stress.
<\/a>Zhao CC, Xu J, Xie QM, Fan XY, Fei GH, Wu HM.
Int Immunopharmacol. 2020 Feb 12;81:106301. doi<\/g>: 10.1016\/j.intimp.2020.106301. [Epub ahead of print<\/p>\n

GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1\u03b1-induced eosinophilic airway inflammation.
<\/a>Sokulsky<\/g>\u00a0LA, Goggins B, Sherwin S, Eyers F, Kaiko GE, Board PG, Keely S, Yang M, Foster PS.
Clin Exp Allergy. 2020 Feb 12.\u00a0doi<\/g>: 10.1111\/cea.13582. [Epub ahead of print]<\/p>\n

Rhein Suppresses\u00a0Lung\u00a0Inflammatory Injury Induced by Human Respiratory Syncytial Virus Through Inhibiting\u00a0NLRP3\u00a0Inflammasome Activation\u00a0via<\/em>\u00a0NF-\u03baB Pathway in Mice.
<\/a>Shen C, Zhang Z, Xie T, Ji J, Xu J, Lin L, Yan J, Kang A, Dai Q, Dong Y, Shan J, Wang S, Zhao X.
Front Pharmacol. 2020 Jan 28;10:1600. doi: 10.3389\/fphar.2019.01600. eCollection 2019.<\/p>\n

NecroX-5\u00a0alleviate<\/g>\u00a0lipopolysaccharide-induced acute respiratory distress syndrome by inhibiting TXNIP\/NLRP3\u00a0and NF-\u03baB.
<\/a>Fang XZ, Ge YL, Chen ZY, Shu HQ, Yang YY, Yu Y, Zhou XJ, Chen L, Cui SN, Wang YX, Yao SL, Shang Y.
Int Immunopharmacol. 2020 Feb 7;81:106257. doi<\/g>: 10.1016\/j.intimp.2020.106257. [Epub ahead of print]<\/p>\n

Mouse pulmonary dose- and time course-responses induced by exposure to nitrogen-doped multi-walled carbon nanotubes.
<\/a>Porter DW,\u00a0Orandle<\/g>\u00a0M, Zheng P, Wu N, Hamilton RF Jr, Holian A, Chen BT, Andrew M, Wolfarth MG, Battelli L, Tsuruoka S, Terrones M, Castranova V.
Inhal Toxicol. 2020 Jan;32(1):24-38.\u00a0doi<\/g>: 10.1080\/08958378.2020.1723746. Epub 2020 Feb 7<\/p>\n

Exosomal miRNA Let-7 from Menstrual Blood-Derived Endometrial Stem Cells Alleviates Pulmonary Fibrosis through Regulating Mitochondrial DNA Damage.
<\/a>Sun L, Zhu M, Feng W, Lin Y, Yin J, Jin J, Wang Y.
Oxid Med Cell Longev. 2019 Dec 16;2019:4506303.\u00a0doi<\/g>: 10.1155\/2019\/4506303. eCollection 2019.<\/p>\n

The\u00a0NLRP3\u00a0inflammasome pathway is activated in sarcoidosis and involved in granuloma formation.
<\/a>Huppertz C, J\u00e4ger B, Wieczorek G, Engelhard P, Oliver SJ, Bauernfeind FG, Littlewood-Evans A, Welte T, Hornung V, Prasse A.
Eur Respir J. 2020 Mar 26;55(3). pii: 1900119. doi: 10.1183\/13993003.00119-2019. Print 2020 Mar.<\/p>\n

Resveratrol protects human bronchial epithelial cells against nickel-induced toxicity via suppressing p38 MAPK, NF-\u03baB signaling, and\u00a0NLRP3\u00a0inflammasome activation.
<\/a>Cao X, Tian S, Fu M, Li Y, Sun Y, Liu J, Liu Y.
Environ Toxicol. 2020 May;35(5):609-618.\u00a0doi<\/g>: 10.1002\/tox.22896. Epub 2020 Jan 13.<\/p>\n

Nonlinear dose-time-response functions and health-protective exposure limits for inflammation-mediated\u00a0diseases.
<\/a>Cox LA Jr.
Environ Res. 2020 Mar;182:109026. doi: 10.1016\/j.envres.2019.109026. Epub 2019 Dec 16.<\/p>\n

Ghrelin alleviates traumatic brain injury-induced acute\u00a0lung\u00a0injury through pyroptosis\/NF-\u03baB pathway.
<\/a>Shao XF, Li B, Shen J, Wang QF, Chen SS, Jiang XC, Qiang D.
Int Immunopharmacol. 2020 Feb;79:106175. doi<\/g>: 10.1016\/j.intimp.2019.106175. Epub 2020 Jan 6<\/p>\n

Dose-response modeling of\u00a0NLRP3\u00a0inflammasome-mediated\u00a0diseases: asbestos,\u00a0lung\u00a0cancer, and malignant mesothelioma as examples.
<\/a>Cox LA Jr.
Crit Rev Toxicol. 2019 Aug;49(7):614-635.\u00a0doi<\/g>: 10.1080\/10408444.2019.1692779. Epub 2020 Jan 6. Review.<\/p>\n

Bruton tyrosine kinase deficiency augments\u00a0NLRP3\u00a0inflammasome activation and causes IL-1\u03b2-mediated colitis.
<\/a>Mao L, Kitani A, Hiejima E, Montgomery-Recht K, Zhou W, Fuss I, Wiestner A, Strober W.
J Clin Invest. 2020 Apr 1;130(4):1793-1807. doi: 10.1172\/JCI128322.<\/p>\n

NALP3 orchestrates cellular bioenergetics to facilitate non-small cell\u00a0lung\u00a0cancer cell growth.
<\/a>He ZF, Jin XR, Lin JJ, Zhang X, Liu Y, Xu HL, Xie DY.
Life Sci. 2020 Jan 15;241:117165. doi: 10.1016\/j.lfs.2019.117165. Epub 2019 Dec 12.<\/p>\n

Particulate matters induce acute exacerbation of allergic airway inflammation via the TLR2\/NF-\u03baB\/NLRP3\u00a0signaling pathway.
<\/a>Dai MY, Chen FF, Wang Y, Wang MZ, Lv YX, Liu RY.
Toxicol Lett. 2020 Mar 15;321:146-154. doi: 10.1016\/j.toxlet.2019.12.013. Epub 2019 Dec 10.<\/p>\n

Anti-inflammatory effect of Yam Glycoprotein on lipopolysaccharide-induced acute\u00a0lung\u00a0injury via the\u00a0NLRP3\u00a0and NF-\u03baB\/TLR4 signaling pathway.
<\/a>Niu X, Zang L, Li W, Xiao X, Yu J, Yao Q, Zhao J, Ye Z, Hu Z, Li W.
Int Immunopharmacol. 2020 Apr;81:106024. doi: 10.1016\/j.intimp.2019.106024. Epub 2019 Nov 26.<\/p>\n

Dexamethasone\u00a0alleviate\u00a0allergic airway inflammation in mice by inhibiting the activation of\u00a0NLRP3inflammasome.
<\/a>Guan M, Ma H, Fan X, Chen X, Miao M, Wu H.
Int Immunopharmacol. 2020 Jan;78:106017. doi: 10.1016\/j.intimp.2019.106017. Epub 2019 Nov 25.<\/p>\n

The HO-1 Signal Prevents HMGB1-Mediated Activation of\u00a0NLRP3\u00a0Inflammasomes in Lipopolysaccharide-Induced Acute\u00a0Lung\u00a0Injury In\u00a0Vitro.
<\/a>Luo M, Hong XQ, Zhu H, Li G, Tang L.
J Surg Res. 2020 Mar;247:335-343. doi: 10.1016\/j.jss.2019.10.011. Epub 2019 Nov 22.<\/p>\n

Activation of\u00a0NLRP3\u00a0inflammasome by lymphocytic microparticles via\u00a0TLR4\u00a0pathway contributes to airway inflammation.
<\/a>Qiu Q, Yang Z, Cao F, Yang C, Hardy P, Yan X, Yang S, Xiong W.
Exp Cell Res. 2020 Jan 15;386(2):111737. doi: 10.1016\/j.yexcr.2019.111737. Epub 2019 Nov 20.<\/p>\n

Pleural mesothelioma and\u00a0lung\u00a0cancer: the role of asbestos exposure and genetic variants in selected iron metabolism and inflammation genes.
<\/a>Celsi F, Crovella S, Moura RR, Schneider M, Vita F, Finotto L, Zabucchi G, Zacchi P, Borelli
J Toxicol Environ Health A. 2019;82(20):1088-1102.\u00a0doi: 10.1080\/15287394.2019.1694612. Epub 2019 Nov 22.<\/p>\n

Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating\u00a0NLRP3\u00a0inflammasome.
<\/a>Wu HM, Xie QM, Zhao CC, Xu J, Fan XY, Fei GH.
Life Sci. 2019 Dec 15;239:117067. doi: 10.1016\/j.lfs.2019.117067. Epub 2019 Nov 16.<\/p>\n

Unique synergistic antiviral effects of Shufeng Jiedu Capsule and oseltamivir in influenza A viral-induced acute exacerbation of\u00a0chronic\u00a0obstructive pulmonary\u00a0disease
<\/a>Ji S, Bai Q, Wu X, Zhang DW, Wang S, Shen JL, Fei GH.
Biomed Pharmacother. 2020 Jan;121:109652. doi: 10.1016\/j.biopha.2019.109652. Epub 2019 Nov 14.<\/p>\n

Vasoactive intestinal peptide suppresses the\u00a0NLRP3\u00a0inflammasome activation in lipopolysaccharide-induced acute\u00a0lung\u00a0injury mice and macrophages.
<\/a>Zhou Y, Zhang CY, Duan\u00a0JX, Li Q, Yang HH, Sun CC, Zhang J, Luo XQ, Liu SK.
Biomed Pharmacother. 2020 Jan;121:109596. doi: 10.1016\/j.biopha.2019.109596. Epub 2019 Nov 12<\/p>\n

Nano-Antagonist Alleviates Inflammation and Allows for MRI of Atherosclerosis.
<\/a>Mog B, Asase C, Chaplin A, Gao H, Rajagopalan S, Maiseyeu A.
Nanotheranostics. 2019 Nov 1;3(4):342-355. doi: 10.7150\/ntno.37391. eCollection 2019.<\/p>\n

Carbon black nanoparticles induce pulmonary fibrosis through\u00a0NLRP3\u00a0inflammasome pathway modulated by miR-96 targeted FOXO3a.
<\/a>Zhou L, Li P, Zhang M, Han B, Chu C, Su X, Li B, Kang H, Ning J, Zhang B, Ma S, Su D, Pang Y, Niu Y, Zhang R.
Chemosphere. 2020 Feb;241:125075. doi: 10.1016\/j.chemosphere.2019.125075. Epub 2019 Oct 11.<\/p>\n

Cellular mechanisms underlying steroid-resistant asthma.
<\/a>Wadhwa R, Dua K, Adcock IM, Horvat JC, Kim RY, Hansbro PM.
Eur Respir Rev. 2019 Oct 21;28(153).\u00a0pii: 190096.\u00a0doi: 10.1183\/16000617.0096-2019. Print 2019 Sep 30. Review. Erratum in:\u00a0Eur Respir Rev. 2019 Nov 13;28(154):<\/a>.<\/p>\n

[Molecular Mechanism of Ventilator-associated\u00a0Lung\u00a0Injury Based on Keap1\/Nfr2\/ARE Signaling Pathway].
<\/a>Xu BS, Liu HT, Ye GD, Cao HC, Mo CL, Tong GQ, Tan YY, Xu X.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 May;50(3):317-322. Chinese.<\/p>\n

ZBP1 governs the inflammasome-independent IL-1\u03b1 and neutrophil inflammation that\u00a0play\u00a0a dual role in anti-influenza virus immunity.
<\/a>Momota M, Lelliott P, Kubo A, Kusakabe T, Kobiyama K, Kuroda E, Imai Y, Akira S, Coban C, Ishii KJ.
Int Immunol. 2020 Mar 7;32(3):203-212. doi: 10.1093\/intimm\/dxz070.<\/p>\n

Electroacupuncture ameliorates cardiopulmonary bypass induced apoptosis in\u00a0lung\u00a0via ROS\/Nrf2\/NLRP3\u00a0inflammasome pathway.
<\/a>Dhar R, Zhang L, Li Y, Rana MN, Hu Z, Li Z, Cui H, Tang H.
Life Sci. 2019 Dec 1;238:116962. doi: 10.1016\/j.lfs.2019.116962. Epub 2019 Oct 16.<\/p>\n

Targeting\u00a0NLRP3\u00a0Inflammasome Activation in Severe Asthma.
<\/a>Theofani\u00a0E, Semitekolou M, Morianos I, Samitas K, Xanthou G.
J Clin Med. 2019 Oct 4;8(10).\u00a0pii: E1615.\u00a0doi: 10.3390\/jcm8101615. Review.<\/p>\n

Is\u00a0NLRP3\u00a0or NLRP6 inflammasome activation associated with inflammation-related\u00a0lungtumorigenesis\u00a0induced by benzo(a)pyrene and lipopolysaccharide?
<\/a>Gao M, Zhang P, Huang L, Shao H, Duan S, Li C, Zhang Q, Wang W, Wu Y, Wang J, Liu H, Feng F.
Ecotoxicol Environ Saf. 2019 Dec 15;185:109687. doi: 10.1016\/j.ecoenv.2019.109687. Epub 2019 Sep 24.<\/p>\n

Prevention of crystalline silica-induced inflammation by the anti-malarial hydroxychloroquine.
<\/a>Burmeister R, Rhoderick JF, Holian A.
Inhal Toxicol. 2019 Jun;31(7):274-284.\u00a0doi: 10.1080\/08958378.2019.1668091. Epub 2019 Sep 26.<\/p>\n

Oridonin attenuates carrageenan-induced pleurisy via activation of the KEAP-1\/Nrf2 pathway and inhibition of the TXNIP\/NLRP3\u00a0and NF-\u03baB pathway in mice
<\/a>Yang H, Huang J, Gao Y, Wen Z, Peng L, Ci X.
Inflammopharmacology. 2020 Apr;28(2):513-523. doi: 10.1007\/s10787-019-00644-y. Epub 2019 Sep 25.<\/p>\n

ENaC-mediated sodium influx exacerbates\u00a0NLRP3-dependent inflammation in cystic fibrosis.
<\/a>Scambler T, Jarosz-Griffiths HH, Lara-Reyna S, Pathak S, Wong C, Holbrook J, Martinon F, Savic S, Peckham D, McDermott MF.
Elife. 2019 Sep 18;8. pii: e49248. doi: 10.7554\/eLife.49248.<\/p>\n

Methanogenic Archaea: Emerging Partners in the Field of Allergic\u00a0Diseases.
<\/a>Sereme Y, Mezouar S, Grine G, Mege JL, Drancourt M, Corbeau P, Vitte J.
Clin Rev Allergy Immunol. 2019 Dec;57(3):456-466. doi: 10.1007\/s12016-019-08766-5. Review.<\/p>\n

Suppression of\u00a0NLRP3\u00a0and NF-\u03baB signaling pathways by \u03b1-Cyperone via activating SIRT1 contributes to\u00a0attenuation\u00a0of LPS-induced acute\u00a0lung\u00a0injury in mice.
<\/a>Liu X, Jin X, Yu D, Liu G.
Int Immunopharmacol. 2019 Nov;76:105886. doi: 10.1016\/j.intimp.2019.105886. Epub 2019 Sep 11.<\/p>\n

Syk-dependent glycolytic reprogramming in dendritic cells regulates IL-1\u03b2 production to \u03b2-glucan ligands in a TLR-independent manner.
<\/a>Thwe\u00a0PM, Fritz DI, Snyder JP, Smith PR, Curtis KD, O’Donnell A, Galasso NA, Sepaniac LA, Adamik BJ, Hoyt LR, Rodriguez PD, Hogan TC, Schmidt AF, Poynter ME, Amiel E.
J Leukoc Biol. 2019 Dec;106(6):1325-1335.\u00a0doi: 10.1002\/JLB.3A0819-207RR. Epub 2019 Sep 11.<\/p>\n

Cystic Fibrosis\u00a0Lung Disease\u00a0and Immunometabolism. Targeting the\u00a0NLRP3\u00a0Inflammasome.
<\/a>Cantin AM.
Am J Respir Crit Care Med. 2019 Dec 1;200(11):1335-1337.\u00a0doi: 10.1164\/rccm.201908-1558ED. No abstract available.<\/p>\n

Curcumin relieves paraquat\u2011induced\u00a0lung\u00a0injury through inhibiting the thioredoxin interacting protein\/NLR pyrin\u00a0domain containing\u00a03\u2011mediated\u00a0inflammatory pathway.
<\/a>Ren Y, Yang Z, Sun Z, Zhang W, Chen X, Nie S.
Mol Med Rep. 2019 Dec;20(6):5032-5040.\u00a0doi: 10.3892\/mmr.2019.10612. Epub 2019 Aug 23.<\/p>\n

NACHT, LRR, and PYD domains-containing Protein 3 and LL-37: prognostic value of new biomarkers in community-acquired pneumonia.
<\/a>Zhu C, Zhou Y, Zhu J, Liu Y, Sun M.
J Bras Pneumol. 2019 Aug 29;45(4):e20190001. doi: 10.1590\/1806-3713\/e20190001. Portuguese, English.<\/p>\n

NLRP3\u00a0inflammasome is attenuated in patients with Mycobacterium\u00a0avium\u00a0complex\u00a0lung disease\u00a0and correlated with decreased interleukin-1\u03b2 response and host susceptibility.
<\/a>Wu MF, Shu CC, Wang JY, Yan BS, Lai HC, Chiang BL, Wu LS, Yu CJ.
Sci Rep. 2019 Aug 29;9(1):12534. doi: 10.1038\/s41598-019-47609-3.<\/p>\n

Specific Inhibition of the\u00a0NLRP3\u00a0Inflammasome as an Antiinflammatory Strategy in Cystic Fibrosis.
<\/a>McElvaney OJ, Zaslona Z, Becker-Flegler K, Palsson-McDermott EM, Boland F, Gunaratnam C, Gulbins E, O’Neill LA, Reeves EP, McElvaney NG.
Am J Respir Crit Care Med. 2019 Dec 1;200(11):1381-1391. doi: 10.1164\/rccm.201905-1013OC.<\/p>\n

Astragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1\/NLRP3\u00a0inflammasome pathway.
<\/a>Qian W, Cai X, Qian Q, Zhuang Q, Yang W, Zhang X, Zhao L.
Drug Des Devel Ther. 2019 Jul 29;13:2579-2589.\u00a0doi: 10.2147\/DDDT.S207774. eCollection 2019.<\/p>\n

Apocynin alleviates\u00a0lung\u00a0injury by suppressing\u00a0NLRP3\u00a0inflammasome activation and NF-\u03baB signaling in acute pancreatitis.
<\/a>Jin HZ, Yang XJ, Zhao KL, Mei FC, Zhou Y, You YD, Wang WX.
Int Immunopharmacol. 2019 Oct;75:105821. doi: 10.1016\/j.intimp.2019.105821. Epub 2019 Aug 19.<\/p>\n

HIF\u20111\u03b1 promotes\u00a0NLRP3\u00a0inflammasome activation in bleomycin\u2011induced acute\u00a0lung\u00a0injury.
<\/a>Huang JJ, Xia J, Huang LL, Li YC.
Mol Med Rep. 2019 Oct;20(4):3424-3432.\u00a0doi: 10.3892\/mmr.2019.10575. Epub 2019 Aug 8.<\/p>\n

Oxidative stress promotes ventilator-induced\u00a0lung\u00a0injury through activating\u00a0NLRP3\u00a0inflammasome and TRPM2 channel.
<\/a>An X, Sun X, Yang X, Liu D, Hou Y, Chen H, Wu J.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3448-3455.\u00a0doi: 10.1080\/21691401.2019.165263<\/p>\n

Attenuation of hyperoxic acute\u00a0lung\u00a0injury by Lycium barbarum polysaccharide via inhibiting\u00a0NLRP3inflammasome.
<\/a>Hong CY, Zhang HD, Liu XY, Xu Y.
Arch Pharm Res. 2019 Oct;42(10):902-908.\u00a0doi: 10.1007\/s12272-019-01175-4. Epub 2019 Aug 6.<\/p>\n

Pulmonary inflammation induced by low-dose particulate matter exposure in mice.
<\/a>Chan YL, Wang B, Chen H, Ho KF, Cao J, Hai G,\u00a0Jalaludin\u00a0B, Herbert C, Thomas PS, Saad S, Oliver BGG.
Am J Physiol\u00a0Lung\u00a0Cell Mol Physiol. 2019 Sep 1;317(3):L424-L430.\u00a0doi: 10.1152\/ajplung.00232.2019. Epub 2019 Jul 31.<\/p>\n

Defining Bronchial Asthma with Phosphoinositide 3-Kinase Delta Activation: Towards Endotype-Driven Management.
<\/a>Jeong JS, Kim JS, Kim SR, Lee YC.
Int J Mol Sci. 2019 Jul 18;20(14).\u00a0pii: E3525.\u00a0doi: 10.3390\/ijms20143525. Review.<\/p>\n

Suhuang\u00a0antitussive capsule inhibits\u00a0NLRP3\u00a0inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.
<\/a>Qin W, Wu X, Jia Y, Tong X, Guo C, Chen D, Wang Z, Tan N.
Biomed Pharmacother. 2019 Oct;118:109188.\u00a0doi: 10.1016\/j.biopha.2019.109188. Epub 2019 Jul 14.<\/p>\n

Ambient particulate matter attenuates Sirtuin1 and augments\u00a0SREBP1-PIR\u00a0axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD.
<\/a>Tien CP, Chen CH, Lin WY, Liu CS, Liu KJ, Hsiao M, Chang YC, Hung SC.
Aging (Albany NY). 2019 Jul 12;11(13):4654-4671.\u00a0doi: 10.18632\/aging.102077.<\/p>\n

Resveratrol alleviates chronic “real-world” ambient particulate matter-induced\u00a0lung\u00a0inflammation and fibrosis by inhibiting\u00a0NLRP3\u00a0inflammasome activation in mice.
<\/a>Ding S, Wang H, Wang M, Bai L, Yu P, Wu W.
Ecotoxicol Environ Saf. 2019 Oct 30;182:109425. doi: 10.1016\/j.ecoenv.2019.109425. Epub 2019 Jul 8.<\/p>\n

TRPV1 and TRPA1 in\u00a0Lung\u00a0Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PM2.5<\/sub>).
<\/a>Xu M, Zhang Y, Wang M, Zhang H, Chen Y, Adcock IM, Chung KF, Mo J, Zhang Y, Li F.
Oxid Med Cell Longev. 2019 Jun 2;2019:7450151.\u00a0doi: 10.1155\/2019\/7450151. eCollection 2019.<\/p>\n

ASC and\u00a0NLRP3\u00a0maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism.
<\/a>Fang R, Uchiyama R, Sakai S, Hara H, Tsutsui H, Suda T, Mitsuyama M, Kawamura I, Tsuchiya K.
Mucosal Immunol. 2019 Sep;12(5):1092-1103.\u00a0doi: 10.1038\/s41385-019-0181-1. Epub 2019 Jul 5.<\/p>\n

Identification of long non-coding RNA and circular RNA in mice after intra-tracheal instillation with fine particulate matter.
<\/a>Zhong Y, Wang Y, Zhang C, Hu Y, Sun C, Liao J, Wang G.
Chemosphere. 2019 Nov;235:519-526. doi: 10.1016\/j.chemosphere.2019.06.122. Epub 2019 Jun 17.<\/p>\n

Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and\u00a0disease\u00a0during influenza virus infection.
<\/a>Rosli S, Kirby FJ, Lawlor KE, Rainczuk K, Drummond GR, Mansell A, Tate MD.
Br J Pharmacol. 2019 Oct;176(19):3834-3844.\u00a0doi: 10.1111\/bph.14787. Epub 2019 Aug 19.<\/p>\n

Increased extracellular vesicle miRNA-466 family in the bronchoalveolar lavage fluid as a precipitating factor of ARDS.
<\/a>Shikano S, Gon Y, Maruoka S, Shimizu T, Kozu Y, Iida Y, Hikichi M, Takahashi M, Okamoto S, Tsuya K, Fukuda A, Mizumura K, Hashimoto S.
BMC Pulm Med. 2019 Jun 20;19(1):110. doi: 10.1186\/s12890-019-0876-9.<\/p>\n

Evaluation of Canonical Inflammasome Activation in Human Monocytes by Imaging Flow Cytometry.
<\/a>Lage SL, Dominical VM, Wong CS, Sereti I.
Front Immunol. 2019 Jun 4;10:1284.\u00a0doi: 10.3389\/fimmu.2019.01284. eCollection 2019.<\/p>\n

Oridonin protects LPS-induced acute\u00a0lung\u00a0injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent\u00a0NLRP3\u00a0and NF-\u03baB pathways.
<\/a>Yang H, Lv H, Li H, Ci X, Peng L.
Cell Commun Signal. 2019 Jun 11;17(1):62. doi: 10.1186\/s12964-019-0366-y.<\/p>\n

Mitochondrial ROS and\u00a0NLRP3\u00a0inflammasome in\u00a0acute\u00a0ozone-induced murine model of airway inflammation and bronchial hyperresponsiveness.
<\/a>Xu M, Wang L, Wang M, Wang H, Zhang H, Chen Y, Wang X, Gong J, Zhang JJ, Adcock IM, Chung KF, Li F.
Free Radic Res. 2019 Jul;53(7):780-790. doi: 10.1080\/10715762.2019.1630735. Epub 2019 Jun 27.<\/p>\n

Risk Analysis Implications of Dose-Response Thresholds for\u00a0NLRP3\u00a0Inflammasome-Mediated\u00a0Diseases: Respirable Crystalline Silica and\u00a0Lung\u00a0Cancer as an Example.
<\/a>Cox LAT Jr.
Dose Response. 2019 Apr 2;17(2):1559325819836900. doi: 10.1177\/1559325819836900. eCollection 2019 Apr-Jun.<\/p>\n

The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity.
<\/a>Li XX, Lee JD, Kemper C, Woodruff TM.
J Immunol. 2019 Jun 15;202(12):3339-3348.\u00a0doi: 10.4049\/jimmunol.1900371. Review.<\/p>\n

Carbon monoxide releasing molecule-2 protects against particulate matter-induced\u00a0lung\u00a0inflammation by inhibiting TLR2 and 4\/ROS\/NLRP3\u00a0inflammasome activation.
<\/a>Lee CW, Chi MC, Hsu LF, Yang CM, Hsu TH, Chuang CC, Lin WN, Chu PM, Lee IT.
Mol Immunol. 2019 Aug;112:163-174. doi: 10.1016\/j.molimm.2019.05.005. Epub 2019 May 29.<\/p>\n

Rev-erb\u03b1 can regulate the NF-\u03baB\/NALP3 pathway to modulate lipopolysaccharide-induced acute\u00a0lunginjury\u00a0and inflammation.
<\/a>Yu D, Fang X, Xu Y, Xiao H, Huang T, Zhang Y, Ge Y, Li Y, Zong L, Gao J.
Int Immunopharmacol. 2019 Aug;73:312-320. doi: 10.1016\/j.intimp.2019.04.035. Epub 2019 May 23.<\/p>\n

Glibenclamide alleviates inflammation in\u00a0oleic\u00a0acid model of acute\u00a0lung\u00a0injury through\u00a0NLRP3inflammasome\u00a0signaling pathway.
<\/a>Chen H, Ding Y, Chen W, Feng Y, Shi G.
Drug Des Devel Ther. 2019 May 7;13:1545-1554. doi: 10.2147\/DDDT.S196040. eCollection 2019.<\/p>\n

NLRP3\u00a0inflammasome activity is upregulated in an in-vitro model of COPD exacerbation.
<\/a>Nachmias N, Langier S, Brzezinski RY, Siterman M, Stark M, Etkin S, Avriel A, Schwarz Y, Shenhar-Tsarfaty S, Bar-Shai A.
PLoS One. 2019 May 21;14(5):e0214622. doi: 10.1371\/journal.pone.0214622. eCollection 2019.<\/p>\n

Inflammasome-Independent and Atypical Processing of IL-1\u03b2\u00a0Contributes\u00a0to Acid Aspiration-Induced Acute\u00a0Lung\u00a0Injury.
<\/a>Mizushina Y, Karasawa T, Aizawa K, Kimura H, Watanabe S, Kamata R, Komada T, Mato N, Kasahara T, Koyama S, Bando M, Hagiwara K, Takahashi M.
J Immunol. 2019 Jul 1;203(1):236-246.\u00a0doi: 10.4049\/jimmunol.1900168. Epub 2019 May 20.<\/p>\n

Is the Inflammasome Pathway Active in the Peripheral Blood of Sulfur Mustard-exposed Patients?
<\/a>Etehad Asnaf S, Sabetghadam M, Jaafarinejad H, Halabian R, Parvin S, Vahedi E, Pazoki N, Salimian J.
Iran J Allergy Asthma Immunol. 2019 Apr 1;18(2):218-224.<\/p>\n

Baicalin tetrazole acts as\u00a0anti-pneumocystis\u00a0carinii\u00a0pneumonia candidate in\u00a0immunosuppressed\u00a0rat model.
<\/a>Chen L, Zhang X, Peng X, Yang Y, Yu H.
Microb Pathog. 2019 Jul;132:59-65. doi: 10.1016\/j.micpath.2019.04.027. Epub 2019 Apr 16.<\/p>\n

Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep.
<\/a>Cade BE, Chen H, Stilp AM, Louie T, Ancoli-Israel S, Arens R, Barfield R, Below JE, Cai J, Conomos MP, Evans DS, Frazier-Wood AC, Gharib SA, Gleason KJ, Gottlieb DJ, Hillman DR, Johnson WC, Lederer DJ, Lee J, Loredo JS, Mei H, Mukherjee S, Patel SR, Post WS, Purcell SM, Ramos AR, Reid KJ, Rice K, Shah NA, Sofer T, Taylor KD, Thornton TA, Wang H, Yaffe K, Zee PC, Hanis CL, Palmer LJ, Rotter JI, Stone KL, Tranah GJ, Wilson JG, Sunyaev SR, Laurie CC, Zhu X, Saxena R, Lin X, Redline S.
PLoS Genet. 2019 Apr 16;15(4):e1007739. doi: 10.1371\/journal.pgen.1007739. eCollection 2019 Apr.<\/p>\n

Platelet\u00a0activating\u00a0factor receptor regulates colitis-induced pulmonary inflammation through the\u00a0NLRP3inflammasome.
<\/a>Liu G, Mateer SW, Hsu A, Goggins BJ, Tay H, Mathe A, Fan K, Neal R, Bruce J, Burns G, Minahan K, Maltby S, Fricker M, Foster PS, Wark PAB, Hansbro PM, Keely S.
Mucosal Immunol. 2019 Jul;12(4):862-873.\u00a0doi: 10.1038\/s41385-019-0163-3. Epub 2019 Apr 11.<\/p>\n

Human metapneumovirus activates NOD-like receptor protein 3 inflammasome via its small hydrophobic protein which plays a detrimental role during infection in mice.
<\/a>L\u00ea VB, Dubois J, Couture C, Cavanagh MH, Uyar O, Pizzorno A, Rosa-Calatrava M, Hamelin M\u00c8, Boivin G.
PLoS Pathog. 2019 Apr 9;15(4):e1007689. doi: 10.1371\/journal.ppat.1007689. eCollection 2019 Apr.<\/p>\n

NLRP3\u00a0inflammasome plays an important role in caspase-1 activation and IL-1\u03b2 secretion in macrophages infected with Pasteurella\u00a0multocida.
<\/a>Fang R, Du H, Lei G, Liu Y, Feng S, Ye C, Li N, Peng Y.
Vet Microbiol. 2019 Apr;231:207-213. doi: 10.1016\/j.vetmic.2019.03.019. Epub 2019 Mar 18.<\/p>\n

Ventilator-induced\u00a0lung\u00a0injury is alleviated by inhibiting\u00a0NLRP3\u00a0inflammasome activation.
<\/a>Liu H, Gu C, Liu M, Liu G, Wang D, Liu X, Wang Y.
Mol Immunol. 2019 Jul;111:1-10. doi: 10.1016\/j.molimm.2019.03.011. Epub 2019 Apr 2.<\/p>\n

Protective effects of propofol on experimental neonatal acute\u00a0lung\u00a0injury.
<\/a>Yu X, Li C.
Mol Med Rep. 2019 May;19(5):4507-4513.\u00a0doi: 10.3892\/mmr.2019.10113. Epub 2019 Apr 1.<\/p>\n

Intranasal Application of Budesonide Attenuates Lipopolysaccharide-Induced Acute\u00a0Lung\u00a0Injury by Suppressing Nucleotide-Binding Oligomerization Domain-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation in Mice.
<\/a>Dong L, Zhu YH, Liu DX, Li J, Zhao PC, Zhong YP, Chen YQ, Xu W, Zhu ZQ.
J Immunol Res. 2019 Feb 27;2019:7264383. doi: 10.1155\/2019\/7264383. eCollection 2019.<\/p>\n

The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and\u00a0lung\u00a0injury in mice by activating SIRT1 and reducing NF-\u03baB acetylation.
<\/a>Peng XP, Li XH, Li Y, Huang XT, Luo ZQ.
Int Immunopharmacol. 2019 May;70:520-529. doi: 10.1016\/j.intimp.2019.03.018. Epub 2019 Mar 19.<\/p>\n

Dihydromyricetin Alleviates Sepsis-Induced Acute\u00a0Lung\u00a0Injury through Inhibiting\u00a0NLRP3Inflammasome-Dependent Pyroptosis in Mice Model.
<\/a>Wang YC, Liu QX, Zheng Q, Liu T, Xu XE, Liu XH, Gao W, Bai XJ, Li ZF.
Inflammation. 2019 Aug;42(4):1301-1310. doi: 10.1007\/s10753-019-00990-7.<\/p>\n

Activation of Nicotinic Acetylcholine \u03b17 Receptor Attenuates Progression of Monocrotaline-Induced Pulmonary Hypertension in Rats by Downregulating the\u00a0NLRP3\u00a0Inflammasome.
<\/a>Deng Y, Guo SL, Wei B, Gao XC, Zhou YC, Li JQ.
Front Pharmacol. 2019 Feb 26;10:128. doi: 10.3389\/fphar.2019.00128. eCollection 2019.<\/p>\n

Carbon nanotubes and crystalline silica stimulate robust ROS production, inflammasome activation, and IL-1\u03b2 secretion in macrophages to induce myofibroblast transformation.
<\/a>Hindman B, Ma Q.
Arch Toxicol. 2019 Apr;93(4):887-907.\u00a0doi: 10.1007\/s00204-019-02411-y. Epub 2019 Mar 7.<\/p>\n

Ameliorative effect of\u00a0gossypin\u00a0against acute\u00a0lung\u00a0injury in\u00a0experimental\u00a0sepsis model of rats.
<\/a>Cinar I, Sirin B, Aydin P, Toktay E, Cadirci E, Halici I, Halici Z.
Life Sci. 2019 Mar 15;221:327-334. doi: 10.1016\/j.lfs.2019.02.039. Epub 2019 Feb 20.<\/p>\n

DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma.
<\/a>Jeong A, Imboden M, Ghantous A, Novoloaca A, Carsin AE, Kogevinas M, Schindler C, Lovison G, Herceg Z, Cuenin C, Vermeulen R, Jarvis D, Amaral AFS, Kronenberg F, Vineis P, Probst-Hensch N.
Int J Environ Res Public Health. 2019 Feb 19;16(4).\u00a0pii: E600.\u00a0doi: 10.3390\/ijerph16040600.<\/p>\n

miR-16 inhibits\u00a0NLRP3\u00a0inflammasome activation by directly targeting TLR4 in acute\u00a0lung\u00a0injury.
<\/a>Yang Y, Yang F, Yu X, Wang B, Yang Y, Zhou X, Cheng R, Xia S, Zhou X.
Biomed Pharmacother. 2019 Apr;112:108664. doi: 10.1016\/j.biopha.2019.108664. Epub 2019 Feb 20.<\/p>\n

Melatonin Alleviates Radiation-Induced\u00a0Lung\u00a0Injury via Regulation of miR-30e\/NLRP3\u00a0Axis.
<\/a>Wu X, Ji H, Wang Y, Gu C, Gu W, Hu L, Zhu L.
Oxid Med Cell Longev. 2019 Jan 10;2019:4087298.\u00a0doi: 10.1155\/2019\/4087298. eCollection 2019.<\/p>\n

MicroRNA\u2011223 attenuates LPS\u2011induced inflammation in an acute\u00a0lung\u00a0injury model via the\u00a0NLRP3inflammasome and TLR4\/NF\u2011\u03baB signaling pathway via RHOB.
<\/a>Yan Y, Lu K, Ye T, Zhang Z.
Int J Mol Med. 2019 Mar;43(3):1467-1477. doi: 10.3892\/ijmm.2019.4075. Epub 2019 Jan 23.<\/p>\n

Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary\u00a0disease-induced depression: A potential mechanism underlying the\u00a0cross talk\u00a0between\u00a0lung\u00a0and brain.
<\/a>Deng X, Fu J, Song Y, Xu B, Ji Z, Guo Q, Ma S.
Brain Behav Immun. 2019 Jul;79:195-206. doi: 10.1016\/j.bbi.2019.02.001. Epub 2019 Feb 6.<\/p>\n

A Novel Insight on Endotyping Heterogeneous Severe Asthma Based on Endoplasmic Reticulum Stress: Beyond the “Type 2\/Non-Type 2 Dichotomy”.
<\/a>Jeong JS, Kim SR, Cho SH, Lee YC.
Int J Mol Sci. 2019 Feb 7;20(3).\u00a0pii: E713.\u00a0doi: 10.3390\/ijms20030713. Review.<\/p>\n

Genetic inactivation of the phospholipase A2<\/sub>\u00a0activity of peroxiredoxin 6 in mice protects against LPS-induced acute\u00a0lung\u00a0injury.
<\/a>V\u00e1zquez-Medina JP, Tao JQ, Patel P, Bannitz-Fernandes R, Dodia C, Sorokina EM, Feinstein SI, Chatterjee S, Fisher AB.
Am J Physiol\u00a0Lung\u00a0Cell Mol Physiol. 2019 Apr 1;316(4):L656-L668.\u00a0doi: 10.1152\/ajplung.00344.2018. Epub 2019 Jan 31.<\/p>\n

NLRP3\u00a0inflammasome activation involved in LPS and coal tar pitch extract-induced malignant transformation of human bronchial epithelial cells.
<\/a>Duan S, Wang N, Huang L, Shao H, Zhang P, Wang W, Wu Y, Wang J, Liu H, Zhang Q, Feng F.
Environ Toxicol. 2019 May;34(5):585-593.\u00a0doi: 10.1002\/tox.22725. Epub 2019 Jan 30.<\/p>\n

NLRP3\u00a0deletion inhibits inflammation-driven mouse\u00a0lung\u00a0tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide.
<\/a>Huang L, Duan S, Shao H, Zhang A, Chen S, Zhang P, Wang N, Wang W, Wu Y, Wang J, Liu H, Yao W, Zhang Q, Feng F.
Respir Res. 2019 Jan 29;20(1):20. doi: 10.1186\/s12931-019-0983-4.<\/p>\n

Electroacupuncture Pretreatment Attenuates Inflammatory\u00a0Lung\u00a0Injury After Cardiopulmonary Bypass by Suppressing\u00a0NLRP3\u00a0Inflammasome Activation in Rats.
<\/a>Huang D, Chen M, Wang Z, Hou L, Yu W.
Inflammation. 2019 Jun;42(3):895-903. doi: 10.1007\/s10753-018-0944-y.<\/p>\n

Inhibition of GGPPS1 attenuated LPS-induced acute\u00a0lung\u00a0injury and was associated with\u00a0NLRP3inflammasome suppression.
<\/a>Xu WJ, Wang XX, Jin JJ, Zou Q, Wu L, Lv TF, Wan B, Zhan P, Zhu SH, Liu HB, Zhao NW, Li CJ, Song Y.
Am J Physiol\u00a0Lung\u00a0Cell Mol Physiol. 2019 Mar 1;316(3):L567-L577.\u00a0doi: 10.1152\/ajplung.00190.2018. Epub 2019 Jan 17.<\/p>\n

[Expression and significance of\u00a0NLRP3\/IL-1\u03b2\/TGF-\u03b2(1) signal axis in\u00a0rat\u00a0model of silicosis pulmonary fibrosis].
<\/a>Song ZS, Shao H, Chen YQ, Zhang R.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018 Nov 20;36(11):819-823.\u00a0doi: 10.3760\/cma.j.issn.1001-9391.2018.11.005. Chinese.<\/p>\n

Roles of TRPA1 and TRPV1 in cigarette\u00a0smoke -induced\u00a0airway epithelial cell injury model.
<\/a>Wang M, Zhang Y, Xu M, Zhang H, Chen Y, Chung KF, Adcock IM, Li F.
Free Radic Biol Med. 2019 Apr;134:229-238.\u00a0doi: 10.1016\/j.freeradbiomed.2019.01.004. Epub 2019 Jan 9.<\/p>\n

NLRP3\u00a0Deficiency Alleviates Severe Acute Pancreatitis and Pancreatitis-Associated\u00a0Lung\u00a0Injury in a Mouse Model.
<\/a>Fu Q, Zhai Z, Wang Y, Xu L, Jia P, Xia P, Liu C, Zhang X, Qin T, Zhang H.
Biomed Res Int. 2018 Nov 28;2018:1294951. doi: 10.1155\/2018\/1294951. eCollection 2018.<\/p>\n

MiR-24 inhibits inflammatory responses in LPS-induced acute\u00a0lung\u00a0injury of neonatal rats through targeting\u00a0NLRP3.
<\/a>Lin Y, Yang Y.
Pathol Res Pract. 2019 Apr;215(4):683-688.\u00a0doi: 10.1016\/j.prp.2018.12.028. Epub 2018 Dec 26<\/p>\n

Inhibition of\u00a0NLRP3\u00a0inflammasome attenuates spinal cord injury-induced\u00a0lung\u00a0injury in mice.
<\/a>Jiang W, Li M, He F, Zhu L.
J Cell Physiol. 2019 May;234(5):6012-6022.\u00a0doi: 10.1002\/jcp.27233. Epub 2018 Dec 27.<\/p>\n

Charcot-Leyden Crystals Activate the\u00a0NLRP3\u00a0Inflammasome and Cause IL-1\u03b2 Inflammation in Human Macrophages.
<\/a>Rodr\u00edguez-Alc\u00e1zar JF, Ataide MA, Engels G, Schmitt-Mabmunyo C, Garbi N, Kastenm\u00fcller W, Latz E, Franklin BS.
J Immunol. 2019 Jan 15;202(2):550-558.\u00a0doi: 10.4049\/jimmunol.1800107. Epub 2018 Dec 17.<\/p>\n

Rapamycin ameliorates lipopolysaccharide-induced acute\u00a0lung\u00a0injury by inhibiting IL-1\u03b2 and IL-18 production.
<\/a>Jia X, Cao B, An Y, Zhang X, Wang C.
Int Immunopharmacol. 2019 Feb;67:211-219. doi: 10.1016\/j.intimp.2018.12.017. Epub 2018 Dec 15.<\/p>\n

Granisetron protects polymicrobial sepsis-induced acute\u00a0lung\u00a0injury in mice.
<\/a>Wang J, Gong S, Wang F, Niu M, Wei G, He Z, Gu T, Jiang Y, Liu A, Chen P.
Biochem Biophys Res Commun. 2019 Jan 22;508(4):1004-1010. doi: 10.1016\/j.bbrc.2018.12.031. Epub 2018 Dec 11.<\/p>\n

Peroxisome\u00a0Proliferator Activated\u00a0Receptor gamma (PPAR\u03b3) Agonist Rosiglitazone Ameliorate Airway Inflammation by Inhibiting Toll-Like Receptor 2 (TLR2)\/Nod-Like Receptor with Pyrin Domain Containing 3 (NLRP3) Inflammatory Corpuscle Activation in Asthmatic Mice.
<\/a>Cheng Y, Li S, Wang M, Cheng C, Liu R.
Med Sci Monit. 2018 Dec 13;24:9045-9053.\u00a0doi: 10.12659\/MSM.910766.<\/p>\n

Fraxin ameliorates lipopolysaccharide-induced acute\u00a0lung\u00a0injury in mice by inhibiting the NF-\u03baB and\u00a0NLRP3\u00a0signallingpathways.
<\/a>Li W, Li W, Zang L, Liu F, Yao Q, Zhao J, Zhi W, Niu X.
Int Immunopharmacol. 2019 Feb;67:1-12. doi: 10.1016\/j.intimp.2018.12.003. Epub 2018 Dec 6.<\/p>\n

Proteomic Profiling of LPS-Induced Macrophage-Derived Exosomes Indicates Their Involvement in Acute Liver Injury.
<\/a>Wang G, Jin S, Ling X, Li Y, Hu Y, Zhang Y, Huang Y, Chen T, Lin J, Ning Z, Meng Y, Li X.
Proteomics. 2019 Feb;19(3):e1800274.\u00a0doi: 10.1002\/pmic.201800274. Epub 2018 Dec 27.<\/p>\n

Withaferin A attenuates\u00a0ovalbumin induced\u00a0airway inflammation.
<\/a>Zhao HM, Gao ZW, Xie SX, Han X, Sun QS.
Front Biosci (Landmark Ed). 2019 Jan 1;24:576-596.<\/p>\n

Roles of mitochondrial ROS and\u00a0NLRP3\u00a0inflammasome in multiple ozone-induced\u00a0lung\u00a0inflammation and emphysema.
<\/a>Li F, Xu M, Wang M, Wang L, Wang H, Zhang H, Chen Y, Gong J, Zhang JJ, Adcock IM, Chung KF, Zhou X.
Respir Res. 2018 Nov 22;19(1):230. doi: 10.1186\/s12931-018-0931-8.<\/p>\n

Chicoric\u00a0acid alleviates lipopolysaccharide-induced acute\u00a0lung\u00a0injury in mice through anti-inflammatory and anti-oxidant activities.
<\/a>Ding H, Ci X, Cheng H, Yu Q, Li D.
Int Immunopharmacol. 2019 Jan;66:169-176. doi: 10.1016\/j.intimp.2018.10.042. Epub 2018 Nov 19.<\/p>\n

IL-1R and Inflammasomes Mediate Early Pulmonary Protective Mechanisms in Respiratory\u00a0Brucella Abortus<\/em>\u00a0Infection.
<\/a>Hielpos MS, Fern\u00e1ndez AG, Falivene J, Alonso Paiva IM, Mu\u00f1oz Gonz\u00e1lez F, Ferrero MC, Campos PC, Vieira AT, Oliveira SC, Baldi PC.
Front Cell Infect Microbiol. 2018 Nov 5;8:391. doi: 10.3389\/fcimb.2018.00391. eCollection 2018.<\/p>\n

The GTPase Rab1 Is Required for\u00a0NLRP3\u00a0Inflammasome Activation and Inflammatory\u00a0Lung\u00a0Injury.
<\/a>Zhang Y, Wang L, Lv Y, Jiang C, Wu G, Dull RO, Minshall RD, Malik AB, Hu G.
J Immunol. 2019 Jan 1;202(1):194-206. doi: 10.4049\/jimmunol.1800777. Epub 2018 Nov 19.<\/p>\n

Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe\u00a0lung\u00a0injury correlated with repressed\u00a0NLRP3\u00a0inflammasome activation and inflammatory cell infiltration.
<\/a>Jia X, Liu B, Bao L, Lv Q, Li F, Li H, An Y, Zhang X, Cao B, Wang C.
PLoS Pathog. 2018 Nov 13;14(11):e1007428. doi: 10.1371\/journal.ppat.1007428. eCollection 2018 Nov.<\/p>\n

New insights in neutrophilic asthma.
<\/a>Seys SF, Lokwani R, Simpson JL, Bullens DMA.
Curr Opin Pulm Med. 2019 Jan;25(1):113-120. doi: 10.1097\/MCP.0000000000000543. Review.<\/p>\n

Protective effects of VGX-1027 in PM2.5<\/sub>-induced airway inflammation and bronchial hyperresponsiveness.
<\/a>Xu M, Li F, Wang M, Zhang H, Xu L, Adcock IM, Chung KF, Zhang Y.
Eur J Pharmacol. 2019 Jan 5;842:373-383. doi: 10.1016\/j.ejphar.2018.11.010. Epub 2018 Nov 9<\/p>\n

Laurus nobilis leaf extract controls inflammation by suppressing\u00a0NLRP3\u00a0inflammasome activation.
<\/a>Lee EH, Shin JH, Kim SS, Lee H, Yang SR, Seo SR.
J Cell Physiol. 2019 May;234(5):6854-6864. doi: 10.1002\/jcp.27434. Epub 2018 Nov 1.<\/p>\n

Estrogen ameliorates allergic airway inflammation by regulating activation of\u00a0NLRP3\u00a0in mice.
<\/a>Cheng C, Wu H, Wang M, Wang L, Zou H, Li S, Liu R.
Biosci Rep. 2019 Jan 8;39(1). pii: BSR20181117. doi: 10.1042\/BSR20181117. Print 2019 Jan 31.<\/p>\n

NLRP3\/Caspase-1 inflammasome activation is decreased in alveolar macrophages in patients with\u00a0lung\u00a0cancer.
<\/a>Lasithiotaki I, Tsitoura E, Samara KD, Trachalaki A, Charalambous I, Tzanakis N, Antoniou KM.
PLoS One. 2018 Oct 26;13(10):e0205242. doi: 10.1371\/journal.pone.0205242. eCollection 2018<\/p>\n

Sevoflurane Inhibits the Th2 Response and\u00a0NLRP3\u00a0Expression in Murine Allergic Airway Inflammation.
<\/a>Wang L, Zha B, Shen Q, Zou H, Cheng C, Wu H, Liu R.
J Immunol Res. 2018 Sep 30;2018:9021037. doi: 10.1155\/2018\/9021037. eCollection 2018.<\/p>\n

Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory\u00a0NLRP3-RXR axis in asthma.
<\/a>Lv J, Su W, Yu Q, Zhang M, Di C, Lin X, Wu M, Xia Z.
J Biol Chem. 2018 Nov 30;293(48):18454-18465. doi: 10.1074\/jbc.RA118.004950. Epub 2018 Oct 17<\/p>\n

The platelet\u00a0NLRP3\u00a0inflammasome is upregulated in sickle cell\u00a0disease\u00a0via HMGB1\/TLR4 and Bruton tyrosine kinase.
<\/a>Vogel S, Arora T, Wang X, Mendelsohn L, Nichols J, Allen D, Shet AS, Combs CA, Quezado ZMN, Thein SL.
Blood Adv. 2018 Oct 23;2(20):2672-2680. doi: 10.1182\/bloodadvances.2018021709.<\/p>\n

[The effects of methylprednisolone on\u00a0NLRP3\u00a0inflammasome in rats with acute\u00a0lung\u00a0injury Induced by Phosgene].
<\/a>Zhou FQ, He DK, Shao YR, Shen J.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018 Aug 20;36(8):573-579. doi: 10.3760\/cma.j.issn.1001-9391.2018.08.003. Chinese.<\/p>\n

Complement receptor CD46 co-stimulates optimal human CD8+<\/sub>\u00a0T cell effector function via fatty acid metabolism.
<\/a>Arbore G, West EE, Rahman J, Le Friec G, Niyonzima N, Pirooznia M, Tunc I, Pavlidis P, Powell N, Li Y, Liu P, Servais A, Couzi L, Fremeaux-Bacchi V, Placais L, Ferraro A, Walsh PR, Kavanagh D, Afzali B, Lavender P, Lachmann HJ, Kemper C.
Nat Commun. 2018 Oct 10;9(1):4186. doi: 10.1038\/s41467-018-06706-z.<\/p>\n

TREM-1 Attenuates RIPK3-mediated Necroptosis in Hyperoxia-induced\u00a0Lung\u00a0Injury in Neonatal Mice.
<\/a>Syed MA, Shah D, Das P, Andersson S, Pryhuber G, Bhandari V.
Am J Respir Cell Mol Biol. 2019 Mar;60(3):308-322. doi: 10.1165\/rcmb.2018-0219OC.<\/p>\n

Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice.
<\/a>Tan HT, Hagner S, Ruchti F, Radzikowska U, Tan G, Altunbulakli C, Eljaszewicz A, Moniuszko M, Akdis M, Akdis CA, Garn H, Sokolowska M.
Allergy. 2019 Feb;74(2):294-307. doi: 10.1111\/all.13619. Epub 2018 Nov 5.<\/p>\n

Protective effects of ethyl acetate extracts of Rimulus Cinnamon on systemic inflammation and\u00a0lunginjury in endotoxin-poisoned mice.
<\/a>Xu F, Sang W, Li L, He X, Wang F, Wen T, Zeng N.
Drug Chem Toxicol. 2019 May;42(3):309-316. doi: 10.1080\/01480545.2018.1509987. Epub 2018 Sep 27.<\/p>\n

Adenovirus-delivered angiopoietin-1 ameliorates phosgene-induced acute\u00a0lung\u00a0injury via inhibition of\u00a0NLRP3\u00a0inflammasome activation.
<\/a>He DK, Chen JF, Shao YR, Zhou FQ, Shen J.
Inhal Toxicol. 2018 Mar – Apr;30(4-5):187-194. doi: 10.1080\/08958378.2018.1492648.<\/p>\n

Inhibition of glycolysis alleviates lipopolysaccharide-induced acute\u00a0lung\u00a0injury in a mouse model.
<\/a>Zhong WJ, Yang HH, Guan XX, Xiong JB, Sun CC, Zhang CY, Luo XQ, Zhang YF, Zhang J, Duan JX, Zhou Y, Guan CX.
J Cell Physiol. 2019 Apr;234(4):4641-4654. doi: 10.1002\/jcp.27261. Epub 2018 Sep 7.<\/p>\n

Apelin-13 Administration Protects Against LPS-Induced Acute\u00a0Lung\u00a0Injury by Inhibiting NF-\u03baB Pathway and\u00a0NLRP3\u00a0Inflammasome Activation.
<\/a>Zhang H, Chen S, Zeng M, Lin D, Wang Y, Wen X, Xu C, Yang L, Fan X, Gong Y, Zhang H, Kong X.
Cell Physiol Biochem. 2018;49(5):1918-1932. doi: 10.1159\/000493653. Epub 2018 Sep 20.<\/p>\n

Polydatin suppresses proliferation and metastasis of non-small cell\u00a0lung\u00a0cancer cells by inhibiting\u00a0NLRP3\u00a0inflammasome activation via NF-\u03baB pathway.
<\/a>Zou J, Yang Y, Yang Y, Liu X.
Biomed Pharmacother. 2018 Dec;108:130-136. doi: 10.1016\/j.biopha.2018.09.051. Epub 2018 Sep 13<\/p>\n

Microbial metabolite sensor GPR43 controls severity of experimental GVHD.
<\/a>Fujiwara H, Docampo MD, Riwes M, Peltier D, Toubai T, Henig I, Wu SJ, Kim S, Taylor A, Brabbs S, Liu C, Zajac C, Oravecz-Wilson K, Sun Y, N\u00fa\u00f1ez G, Levine JE, van den Brink MRM, Ferrara JLM, Reddy P.
Nat Commun. 2018 Sep 10;9(1):3674. doi: 10.1038\/s41467-018-06048-w.<\/p>\n

SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death.
<\/a>Yue Y, Nabar NR, Shi CS, Kamenyeva O, Xiao X, Hwang IY, Wang M, Kehrl JH.
Cell Death Dis. 2018 Sep 5;9(9):904. doi: 10.1038\/s41419-018-0917-y.<\/p>\n

Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials.
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Chem Res Toxicol. 2018 Oct 15;31(10):994-1008. doi: 10.1021\/acs.chemrestox.8b00146. Epub 2018 Sep 12.<\/p>\n

Complement regulatory protein CD46 induces autophagy against oxidative stress-mediated apoptosis in normal and asthmatic airway epithelium.
<\/a>Tsai YG, Wen YS, Wang JY, Yang KD, Sun HL, Liou JH, Lin CY.
Sci Rep. 2018 Aug 28;8(1):12973. doi: 10.1038\/s41598-018-31317-5.<\/p>\n

Regulation of the\u00a0NLRP3\u00a0inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute\u00a0lung\u00a0injury.
<\/a>Li D, Ren W, Jiang Z, Zhu L.
Mol Med Rep. 2018 Nov;18(5):4399-4409. doi: 10.3892\/mmr.2018.9427. Epub 2018 Aug 24.<\/p>\n

The selective\u00a0Nlrp3\u00a0inflammasome inhibitor Mcc950 attenuates\u00a0lung\u00a0ischemia-reperfusion injury.
<\/a>Xu KY, Wu CY, Tong S, Xiong P, Wang SH.
Biochem Biophys Res Commun. 2018 Sep 18;503(4):3031-3037. doi: 10.1016\/j.bbrc.2018.08.089. Epub 2018 Aug 23.<\/p>\n

Commensal bacteria aggravate allergic asthma via\u00a0NLRP3\/IL-1\u03b2 signaling in post-weaning mice.
<\/a>Huang C, Wang J, Zheng X, Chen Y, Zhou R, Wei H, Sun R, Tian Z.
J Autoimmun. 2018 Sep;93:104-113. doi: 10.1016\/j.jaut.2018.07.003. Epub 2018 Jul 7.<\/p>\n

RIP3 dependent\u00a0NLRP3\u00a0inflammasome activation is implicated in acute\u00a0lung\u00a0injury in mice.
<\/a>Chen J, Wang S, Fu R, Zhou M, Zhang T, Pan W, Yang N, Huang Y.
J Transl Med. 2018 Aug 20;16(1):233. doi: 10.1186\/s12967-018-1606-4<\/p>\n

An ethnobotanical survey and inhibitory effects on\u00a0NLRP3\u00a0inflammasomes\/Caspase-1 of herbal recipes’ extracts traditionally used in Rwanda for asthma treatment.
<\/a>Tomani JCD, Gainkam LOT, Nshutiyayesu S, Mukazayire MJ, Ribeiro SO, Stevigny C, Frederich M, Muganga R, Souopgui J.
J Ethnopharmacol. 2018 Dec 5;227:29-40. doi: 10.1016\/j.jep.2018.08.016. Epub 2018 Aug 14.<\/p>\n

Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR\/Akt signaling and predicts a good prognosis in non\u2011small cell\u00a0lungcancer.
<\/a>Gao J, Qiu X, Xi G, Liu H, Zhang F, Lv T, Song Y.
Oncol Rep. 2018 Oct;40(4):1971-1984. doi: 10.3892\/or.2018.6634. Epub 2018 Aug 7.<\/p>\n

C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation.
<\/a>Richter K, Sagawe S, Hecker A, K\u00fcllmar M, Askevold I, Damm J, Heldmann S, P\u00f6hlmann M, Ruhrmann S, Sander M, Schl\u00fcter KD, Wilker S, K\u00f6nig IR, Kummer W, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz AT, Koch C, Grau V.
Front Immunol. 2018 Jul 30;9:1604. doi: 10.3389\/fimmu.2018.01604. eCollection 2018.<\/p>\n

The anti-inflammatory effect of BML-111 on COPD may be mediated by regulating\u00a0NLRP3inflammasome activation and ROS production.
<\/a>Cao Y, Zhou X, Yin Z, Yu X, Yang Q, Guo Q, Tian D, Xiong X, Xu G, Kuang X.
Prostaglandins Other Lipid Mediat. 2018 Sep;138:23-30. doi: 10.1016\/j.prostaglandins.2018.08.001. Epub 2018 Aug 10.<\/p>\n

Dexmedetomidine attenuates lipopolysaccharide induced acute\u00a0lung\u00a0injury by targeting\u00a0NLRP3\u00a0via miR-381.
<\/a>Zhang Y, Wang X, Liu Z, Yu L.
J Biochem Mol Toxicol. 2018 Nov;32(11):e22211. doi: 10.1002\/jbt.22211. Epub 2018 Aug 13.<\/p>\n

Swine Influenza Virus Induces RIPK1\/DRP1-Mediated Interleukin-1 Beta Production.
<\/a>Park HS, Liu G, Liu Q, Zhou Y.
Viruses. 2018 Aug 9;10(8). pii: E419. doi: 10.3390\/v10080419.<\/p>\n

Kinome analyses of inflammatory responses to swine barn dust extract in human bronchial epithelial and monocyte cell lines.
<\/a>Nath Neerukonda S, Mahadev-Bhat S, Aylward B, Johnson C, Charavaryamath C, Arsenault RJ.
Innate Immun. 2018 Aug;24(6):366-381. doi: 10.1177\/1753425918792070. Epub 2018 Aug 9.<\/p>\n

NLRP3\u00a0inflammasome activation and\u00a0lung\u00a0fibrosis caused by airborne fine particulate matter.
<\/a>Zheng R, Tao L, Jian H, Chang Y, Cheng Y, Feng Y, Zhang H.
Ecotoxicol Environ Saf. 2018 Nov 15;163:612-619. doi: 10.1016\/j.ecoenv.2018.07.076. Epub 2018 Aug 6.<\/p>\n

Protective Effects of Nintedanib against Polyhexamethylene Guanidine Phosphate-Induced\u00a0LungFibrosis in Mice.
<\/a>Kim HY, Kim MS, Kim SH, Joen D, Lee K.
Molecules. 2018 Aug 7;23(8). pii: E1974. doi: 10.3390\/molecules23081974.<\/p>\n

NLRP3\u00a0deficiency exacerbates enterovirus infection in mice.
<\/a>Wang C, Fung G, Deng H, Jagdeo J, Mohamud Y, Xue YC, Jan E, Hirota JA, Luo H.
FASEB J. 2019 Jan;33(1):942-952. doi: 10.1096\/fj.201800301RRR. Epub 2018 Aug 6.<\/p>\n

Ozone protects the rat\u00a0lung\u00a0from ischemia-reperfusion injury by attenuating\u00a0NLRP3-mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis.
<\/a>Wang Z, Zhang A, Meng W, Wang T, Li D, Liu Z, Liu H.
Eur J Pharmacol. 2018 Sep 15;835:82-93. doi: 10.1016\/j.ejphar.2018.07.059. Epub 2018 Jul 31.<\/p>\n

Procyanidin B2 protects rats from paraquat-induced acute\u00a0lung\u00a0injury by inhibiting\u00a0NLRP3inflammasome activation.
<\/a>Jiang Y, Yang W, Gui S.
Immunobiology. 2018 Oct;223(10):555-561. doi: 10.1016\/j.imbio.2018.07.001. Epub 2018 Jul 6.<\/p>\n

A Pilot Study To Investigate the Immune-Modulatory Effects of Fasting in Steroid-Naive Mild Asthmatics.
<\/a>Han K, Nguyen A, Traba J, Yao X, Kaler M, Huffstutler RD, Levine SJ, Sack MN.
J Immunol. 2018 Sep 1;201(5):1382-1388. doi: 10.4049\/jimmunol.1800585. Epub 2018 Jul 18.<\/p>\n

Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of\u00a0NLRP3\u00a0inflammasome and IL-1\u03b2 in rats with COPD.
<\/a>Peng Z, Zhang W, Qiao J, He B.
Int Immunopharmacol. 2018 Sep;62:23-28. doi: 10.1016\/j.intimp.2018.06.033. Epub 2018 Jun 30.<\/p>\n

[Interventional effects of BAY11-7082 on\u00a0lung\u00a0inflammatory response at the early stage and acute\u00a0lung\u00a0injury of rats with severe burns].
<\/a>Li HS, Yang XK, Hao ZM, Lei J.
Zhonghua Shao Shang Za Zhi. 2018 Feb 20;34(2):88-95. doi: 10.3760\/cma.j.issn.1009-2587.2018.02.006. Chinese.<\/p>\n

Interleukin-18 and the NLR family pyrin domain containing-3 inflammasome in adipose tissue are strongly associated with glucometabolic variables in a cohort of middle-aged men.
<\/a>\u00c5kra S, Aksnes TA, Flaa A, Eggesb\u00f8 HB, Opstad TB, Njerve IU, Seljeflot I.
Diab Vasc Dis Res. 2018 Sep;15(5):458-464. doi: 10.1177\/1479164118785307. Epub 2018 Jul 4.<\/p>\n

The TWIK2 Potassium Efflux Channel in Macrophages Mediates\u00a0NLRP3\u00a0Inflammasome-Induced Inflammation.
<\/a>Di A, Xiong S, Ye Z, Malireddi RKS, Kometani S, Zhong M, Mittal M, Hong Z, Kanneganti TD, Rehman J, Malik AB
Immunity. 2018 Jul 17;49(1):56-65.e4. doi: 10.1016\/j.immuni.2018.04.032. Epub 2018 Jun 26<\/p>\n

Biological mechanisms of non-linear dose-response for respirable mineral fibers.
<\/a>Cox LAT Jr.
Toxicol Appl Pharmacol. 2018 Dec 15;361:137-144. doi: 10.1016\/j.taap.2018.06.016. Epub 2018 Jun 20. Review.<\/p>\n

SOCS-1 Suppresses Inflammation Through Inhibition of NALP3 Inflammasome Formation in Smoke Inhalation-Induced Acute\u00a0Lung\u00a0Injury.
<\/a>Zhang L, Xu C, Chen X, Shi Q, Su W, Zhao H.
Inflammation. 2018 Aug;41(4):1557-1567. doi: 10.1007\/s10753-018-0802-y.<\/p>\n

Electroporation-mediated delivery of FER gene enhances innate immune response and improves survival in a murine model of pneumonia.
<\/a>Dolgachev V, Panicker S, Balijepalli S, McCandless LK, Yin Y, Swamy S, Suresh MV, Delano MJ, Hemmila MR, Raghavendran K, Machado-Aranda D.
Gene Ther. 2018 Aug;25(5):359-375. doi: 10.1038\/s41434-018-0022-y. Epub 2018 Jun 15.<\/p>\n

Inflammatory mediators ATP and S100A12 activate the\u00a0NLRP3\u00a0inflammasome to induce MUC5AC production in airway epithelial cells.
<\/a>Kim K, Kim HJ, Binas B, Kang JH, Chung IY.
Biochem Biophys Res Commun. 2018 Sep 5;503(2):657-664. doi: 10.1016\/j.bbrc.2018.06.057. Epub 2018 Jun 15.<\/p>\n

NLRP3\u00a0inflammasome: A likely target for the treatment of allergic\u00a0diseases.
<\/a>Xiao Y, Xu W, Su W.
Clin Exp Allergy. 2018 Sep;48(9):1080-1091. doi: 10.1111\/cea.13190. Epub 2018 Jul 3. Review.<\/p>\n

NLRP3\/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute\u00a0lunginjury induced by cardiopulmonary bypass.
<\/a>Hou L, Yang Z, Wang Z, Zhang X, Zhao Y, Yang H, Zheng B, Tian W, Wang S, He Z, Wang X.
Lab Invest. 2018 Aug;98(8):1052-1064. doi: 10.1038\/s41374-018-0073-0. Epub 2018 Jun 8.<\/p>\n

Jinxin oral liquid inhibits human respiratory syncytial virus-induced excessive inflammation associated with blockade of the\u00a0NLRP3\/ASC\/Caspase-1 pathway.
<\/a>Shen C, Zhang Z, Xie T, Xu J, Yan J, Kang A, Dai Q, Wang S, Ji J, Shan J.
Biomed Pharmacother. 2018 Jul;103:1376-1383. doi: 10.1016\/j.biopha.2018.04.174. Epub 2018 May 7.<\/p>\n

Saturated fatty acids, obesity, and the nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in asthmatic patients.
<\/a>Wood LG, Li Q, Scott HA, Rutting S, Berthon BS, Gibson PG, Hansbro PM, Williams E, Horvat J, Simpson JL, Young P, Oliver BG, Baines KJ.
J Allergy Clin Immunol. 2019 Jan;143(1):305-315. doi: 10.1016\/j.jaci.2018.04.037. Epub 2018 May 30.<\/p>\n

Linarin prevents LPS\u2011induced acute\u00a0lung\u00a0injury by suppressing oxidative stress and inflammation via inhibition of TXNIP\/NLRP3\u00a0and NF\u2011\u03baB pathways.
<\/a>Han X, Wu YC, Meng M, Sun QS, Gao SM, Sun H.
Int J Mol Med. 2018 Sep;42(3):1460-1472. doi: 10.3892\/ijmm.2018.3710. Epub 2018 May 30.<\/p>\n

Caspase-11-dependent pyroptosis of\u00a0lung\u00a0epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18.
<\/a>Wang J, Sahoo M, Lantier L, Warawa J, Cordero H, Deobald K, Re F.
PLoS Pathog. 2018 May 23;14(5):e1007105. doi: 10.1371\/journal.ppat.1007105. eCollection 2018 May.<\/p>\n

Pirfenidone ameliorates lipopolysaccharide-induced pulmonary inflammation and fibrosis by blocking\u00a0NLRP3\u00a0inflammasome activation.
<\/a>Li Y, Li H, Liu S, Pan P, Su X, Tan H, Wu D, Zhang L, Song C, Dai M, Li Q, Mao Z, Long Y, Hu Y, Hu C.
Mol Immunol. 2018 Jul;99:134-144. doi: 10.1016\/j.molimm.2018.05.003. Epub 2018 May 26.<\/p>\n

Effects and molecular mechanisms of intrauterine infection\/inflammation on\u00a0lung\u00a0development.
<\/a>Pan J, Zhan C, Yuan T, Wang W, Shen Y, Sun Y, Wu T, Gu W, Chen L, Yu H.
Respir Res. 2018 May 10;19(1):93. doi: 10.1186\/s12931-018-0787-y.<\/p>\n

Artesunate Inhibits Renal Ischemia-Reperfusion-Mediated Remote\u00a0Lung\u00a0Inflammation Through Attenuating ROS-Induced Activation of\u00a0NLRP3\u00a0Inflammasome.
<\/a>Liu Z, Qu M, Yu L, Song P, Chang Y.
Inflammation. 2018 Aug;41(4):1546-1556. doi: 10.1007\/s10753-018-0801-z.<\/p>\n

Mitochondrial Autophagy and\u00a0NLRP3\u00a0Inflammasome in Pulmonary Tissues from Severe Combined Immunodeficient Mice after Cardiac Arrest and Cardiopulmonary Resuscitation.
<\/a>Lyu JJ, Mehta JL, Li Y, Ye L, Sun SN, Sun HS, Li JC, Zhang DM, Wei J.
Chin Med J (Engl). 2018 May 20;131(10):1174-1184. doi: 10.4103\/0366-6999.231519<\/p>\n

Vitexin attenuates lipopolysaccharide-induced acute\u00a0lung\u00a0injury by controlling the Nrf2 pathway.
<\/a>Lu Y, Yu T, Liu J, Gu L.
PLoS One. 2018 Apr 25;13(4):e0196405. doi: 10.1371\/journal.pone.0196405. eCollection 2018.<\/p>\n

Autoinflammatory\u00a0disease\u00a0in the\u00a0lung.
<\/a>Scambler T, Holbrook J, Savic S, McDermott MF, Peckham D.
Immunology. 2018 Apr 19. doi: 10.1111\/imm.12937. [Epub ahead of print] Review.<\/p>\n

Activation of the Absent in Melanoma 2 Inflammasome in Peripheral Blood Mononuclear Cells From Idiopathic Pulmonary Fibrosis Patients Leads to the Release of Pro-Fibrotic Mediators.
<\/a>Terlizzi M, Molino A, Colarusso C, Donovan C, Imitazione P, Somma P, Aquino RP, Hansbro PM, Pinto A, Sorrentino R.
Front Immunol. 2018 Apr 5;9:670. doi: 10.3389\/fimmu.2018.00670. eCollection 2018.<\/p>\n

NLRP3\u00a0Inflammasome Involves in the Acute Exacerbation of Patients with Chronic Obstructive Pulmonary\u00a0Disease.
<\/a>Wang H, Lv C, Wang S, Ying H, Weng Y, Yu W.
Inflammation. 2018 Aug;41(4):1321-1333. doi: 10.1007\/s10753-018-0780-0<\/p>\n

NLRP3\u00a0regulates macrophage M2 polarization through up-regulation of IL-4 in asthma.
<\/a>Liu Y, Gao X, Miao Y, Wang Y, Wang H, Cheng Z, Wang X, Jing X, Jia L, Dai L, Liu M, An L.
Biochem J. 2018 Jun 21;475(12):1995-2008. doi: 10.1042\/BCJ20180086.<\/p>\n

Airway epithelial phosphoinositide 3-kinase-\u03b4 contributes to the modulation of fungi-induced innate immune response.
<\/a>Jeong JS, Lee KB, Kim SR, Kim DI, Park HJ, Lee HK, Kim HJ, Cho SH, Kolliputi N, Kim SH, Lee YC.
Thorax. 2018 Aug;73(8):758-768. doi: 10.1136\/thoraxjnl-2017-210326. Epub 2018 Apr 5.<\/p>\n

The inflammasome potentiates influenza\/Staphylococcus aureus superinfection in mice.
<\/a>Robinson KM, Ramanan K, Clay ME, McHugh KJ, Pilewski MJ, Nickolich KL, Corey C, Shiva S, Wang J, Muzumdar R, Alcorn JF.
JCI Insight. 2018 Apr 5;3(7). pii: 97470. doi: 10.1172\/jci.insight.97470. eCollection 2018 Apr 5.<\/p>\n

Inflammasome-Independent Leukotriene B4<\/sub>\u00a0Production Drives Crystalline Silica-Induced Sterile Inflammation.
<\/a>Hegde B, Bodduluri SR, Satpathy SR, Alghsham RS, Jala VR, Uriarte SM, Chung DH, Lawrenz MB, Haribabu B.
J Immunol. 2018 May 15;200(10):3556-3567. doi: 10.4049\/jimmunol.1701504. Epub 2018 Apr 2.<\/p>\n

Nebulized lidocaine ameliorates allergic airway inflammation via downregulation of TLR2.
<\/a>Wang L, Wang M, Li S, Wu H, Shen Q, Zhang S, Fang L, Liu R.
Mol Immunol. 2018 May;97:94-100. doi: 10.1016\/j.molimm.2018.03.010. Epub 2018 Mar 30.<\/p>\n

Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the\u00a0NLRP3\u00a0Inflammasome through the PGC-1\u03b1\/TNFAIP3 Axis.
<\/a>Kang Y, Zhang H, Zhao Y, Wang Y, Wang W, He Y, Zhang W, Zhang W, Zhu X, Zhou Y, Zhang L, Ju Z, Shi L.
Cell Rep. 2018 Mar 27;22(13):3493-3506. doi: 10.1016\/j.celrep.2018.02.071.<\/p>\n

Effect of Soluble Epoxide Hydrolase in Hyperoxic Acute\u00a0Lung\u00a0Injury in Mice.
<\/a>Li PS, Tao W, Yang LQ, Shu YS.
Inflammation. 2018 Jun;41(3):1065-1072. doi: 10.1007\/s10753-018-0758-y.<\/p>\n

Atractylodin attenuates lipopolysaccharide-induced acute\u00a0lung\u00a0injury by inhibiting\u00a0NLRP3inflammasome and TLR4 pathways.
<\/a>Tang F, Fan K, Wang K, Bian C.
J Pharmacol Sci. 2018 Apr;136(4):203-211. doi: 10.1016\/j.jphs.2017.11.010. Epub 2018 Feb 2.<\/p>\n

Involvement of TLR4 and PPAR-\u03b1 Receptors in Host Response and\u00a0NLRP3\u00a0Inflammasome Activation, Against Pulmonary Infection With Pseudomonas Aeruginosa.
<\/a>Gugliandolo E, Fusco R, Ginestra G, D’amico R, Bisignano C, Mandalari G, Cuzzocrea S, Di Paola R.
Shock. 2019 Feb;51(2):221-227. doi: 10.1097\/SHK.0000000000001137.<\/p>\n

ATP\/P2X7-NLRP3\u00a0axis of dendritic cells participates in the regulation of airway inflammation and hyper-responsiveness in asthma by mediating HMGB1 expression and secretion.
<\/a>Li R, Wang J, Li R, Zhu F, Xu W, Zha G, He G, Cao H, Wang Y, Yang J.
Exp Cell Res. 2018 May 1;366(1):1-15. doi: 10.1016\/j.yexcr.2018.03.002. Epub 2018 Mar 12.<\/p>\n

Effects on IL-1\u03b2 signaling activation induced by water and organic extracts of fine particulate matter (PM2.5<\/sub>) in\u00a0vitro.
<\/a>Xu F, Qiu X, Hu X, Shang Y, Pardo M, Fang Y, Wang J, Rudich Y, Zhu T.
Environ Pollut. 2018 Jun;237:592-600. doi: 10.1016\/j.envpol.2018.02.086. Epub 2018 Mar 15.<\/p>\n

Oleanolic acid acetate attenuates polyhexamethylene guanidine phosphate-induced pulmonary inflammation and fibrosis in mice.
<\/a>Kim MS, Han JY, Kim SH, Jeon D, Kim HY, Lee SW, Rho MC, Lee K.
Respir Physiol Neurobiol. 2018 Jun;252-253:1-9. doi: 10.1016\/j.resp.2018.03.001. Epub 2018 Mar 2.<\/p>\n

Development of tissue inflammation accompanied by\u00a0NLRP3\u00a0inflammasome activation in rabbits infected with Treponema pallidum strain Nichols.
<\/a>Lin LR, Xiao Y, Liu W, Chen YY, Zhu XZ, Gao ZX, Gao K, Tong ML, Zhang HL, Li SL, Lin HL, Li WD, Liang XM, Lin Y, Liu LL, Yang TC.
BMC Infect Dis. 2018 Mar 1;18(1):101. doi: 10.1186\/s12879-018-2993-0.<\/p>\n

Autophagy Attenuates Angiotensin II-Induced Pulmonary Fibrosis by Inhibiting Redox Imbalance-Mediated NOD-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation.
<\/a>Meng Y, Pan M, Zheng B, Chen Y, Li W, Yang Q, Zheng Z, Sun N, Zhang Y, Li X.
Antioxid Redox Signal. 2019 Feb 1;30(4):520-541. doi: 10.1089\/ars.2017.7261. Epub 2018 May 7.<\/p>\n

RAGE-induced changes in the proteome of alveolar epithelial cells.
<\/a>Downs CA, Johnson NM, Tsaprailis G, Helms MN.
J Proteomics. 2018 Apr 15;177:11-20. doi: 10.1016\/j.jprot.2018.02.010. Epub 2018 Feb 12.<\/p>\n

Inflammatory Monocytes Drive Influenza A Virus-Mediated\u00a0Lung\u00a0Injury in Juvenile Mice.
<\/a>Coates BM, Staricha KL, Koch CM, Cheng Y, Shumaker DK, Budinger GRS, Perlman H, Misharin AV, Ridge KM.
J Immunol. 2018 Apr 1;200(7):2391-2404. doi: 10.4049\/jimmunol.1701543. Epub 2018 Feb 14.<\/p>\n

Macrophage Recognition of Crystals and Nanoparticles.
<\/a>Nakayama M.
Front Immunol. 2018 Jan 29;9:103. doi: 10.3389\/fimmu.2018.00103. eCollection 2018. Review.<\/p>\n

The NALP3 inflammasome is required for collagen synthesis via the NF\u2011\u03baB pathway.
<\/a>Kuang J, Xie M, Wei X.
Int J Mol Med. 2018 Apr;41(4):2279-2287. doi: 10.3892\/ijmm.2018.3404. Epub 2018 Jan 18.<\/p>\n

Platelets at the crossroads of thrombosis, inflammation and haemolysis.
<\/a>Vogel S, Thein SL.
Br J Haematol. 2018 Mar;180(5):761-767. doi: 10.1111\/bjh.15117. Epub 2018 Jan 30.<\/p>\n

OLT1177, a \u03b2-sulfonyl nitrile compound, safe in humans, inhibits the\u00a0NLRP3\u00a0inflammasome and reverses the metabolic cost of inflammation.
<\/a>Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D’Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA.
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073\/pnas.1716095115. Epub 2018 Jan 29.<\/p>\n

Galectin-3 Enhances Avian H5N1 Influenza A Virus-Induced Pulmonary Inflammation by Promoting\u00a0NLRP3\u00a0Inflammasome Activation.
<\/a>Chen YJ, Wang SF, Weng IC, Hong MH, Lo TH, Jan JT, Hsu LC, Chen HY, Liu FT.
Am J Pathol. 2018 Apr;188(4):1031-1042. doi: 10.1016\/j.ajpath.2017.12.014. Epub 2018 Jan 31.<\/p>\n

Yupingfeng San<\/em>\u00a0Inhibits\u00a0NLRP3\u00a0Inflammasome to Attenuate the Inflammatory Response in Asthma Mice.
<\/a>Liu X, Shen J, Fan D, Qiu X, Guo Q, Zheng K, Luo H, Shu J, Lu C, Zhang G, Lu A, Ma C, He X.
Front Pharmacol. 2017 Dec 22;8:944. doi: 10.3389\/fphar.2017.00944. eCollection 2017.<\/p>\n

Gene mutations and clinical phenotypes in 15 Chinese children with cryopyrin-associated periodic syndrome (CAPS).
<\/a>Li C, Tan X, Zhang J, Li S, Mo W, Han T, Kuang W, Zhou Y, Deng J.
Sci China Life Sci. 2017 Dec;60(12):1436-1444. doi: 10.1007\/s11427-017-9246-4. Epub 2017 Dec 2.<\/p>\n

Resveratrol alleviates\u00a0Staphylococcus aureus<\/em>\u00a0pneumonia by inhibition of the\u00a0NLRP3\u00a0inflammasome.
<\/a>Wu S, Huang J.
Exp Ther Med. 2017 Dec;14(6):6099-6104. doi: 10.3892\/etm.2017.5337. Epub 2017 Oct 18.<\/p>\n

NLRP3\u00a0Controls the Development of Gastrointestinal CD11b+<\/sub>\u00a0Dendritic Cells in the Steady State and during Chronic Bacterial Infection.
<\/a>Arnold IC, Zhang X, Urban S, Artola-Bor\u00e1n M, Manz MG, Ottemann KM, M\u00fcller A.
Cell Rep. 2017 Dec 26;21(13):3860-3872. doi: 10.1016\/j.celrep.2017.12.015.<\/p>\n

Nanoparticle-induced inflammation can increase tumor malignancy.
<\/a>Manshian BB, Poelmans J, Saini S, Pokhrel S, Grez JJ, Himmelreich U, M\u00e4dler L, Soenen SJ.
Acta Biomater. 2018 Mar 1;68:99-112. doi: 10.1016\/j.actbio.2017.12.020. Epub 2017 Dec 20.<\/p>\n

NLRP3\u00a0inflammasome inhibition attenuates silica-induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells.
<\/a>Li X, Yan X, Wang Y, Wang J, Zhou F, Wang H, Xie W, Kong H.
Exp Cell Res. 2018 Jan 15;362(2):489-497. doi: 10.1016\/j.yexcr.2017.12.013. Epub 2017 Dec 16.<\/p>\n

Protective effect of baicalin against severe burn\u2011induced remote acute\u00a0lung\u00a0injury in rats.
<\/a>Bai C, Li T, Sun Q, Xin Q, Xu T, Yu J, Wang Y, Wei L.
Mol Med Rep. 2018 Feb;17(2):2689-2694. doi: 10.3892\/mmr.2017.8120. Epub 2017 Nov 20.<\/p>\n

Decreased\u00a0NLRP3\u00a0inflammasome expression in aged\u00a0lung\u00a0may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection.
<\/a>Cho SJ, Plataki M, Mitzel D, Lowry G, Rooney K, Stout-Delgado H.
Exp Gerontol. 2018 May;105:40-46. doi: 10.1016\/j.exger.2017.11.010. Epub 2017 Dec 7.<\/p>\n

Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein.
<\/a>Shil NK, Pokharel SM, Banerjee AK, Hoffman M, Bose S.
J Virol. 2018 Jan 30;92(4). pii: e01776-17. doi: 10.1128\/JVI.01776-17. Print 2018 Feb 15.<\/p>\n

The Human-Associated Archaeon\u00a0Methanosphaera stadtmanae<\/em>\u00a0Is Recognized through Its RNA and Induces TLR8-Dependent\u00a0NLRP3\u00a0Inflammasome Activation.
<\/a>Vierbuchen T, Bang C, Rosigkeit H, Schmitz RA, Heine H.
Front Immunol. 2017 Nov 13;8:1535. doi: 10.3389\/fimmu.2017.01535. eCollection 2017.<\/p>\n

Antimycobacterial and Anti-inflammatory Mechanisms of Baicalin via Induced Autophagy in Macrophages Infected with\u00a0Mycobacterium tuberculosis<\/em>.
<\/a>Zhang Q, Sun J, Wang Y, He W, Wang L, Zheng Y, Wu J, Zhang Y, Jiang X.
Front Microbiol. 2017 Nov 2;8:2142. doi: 10.3389\/fmicb.2017.02142. eCollection 201<\/p>\n

Vitamin D3 levels and\u00a0NLRP3\u00a0expression in murine models of obese asthma: association with asthma outcomes.
<\/a>Zhang JH, Chen YP, Yang X, Li CQ.
Braz J Med Biol Res. 2017 Nov 13;51(1):e6841. doi: 10.1590\/1414-431X20176841.<\/p>\n

Polymorphisms in inflammasome genes and risk of asthma in Brazilian children.
<\/a>Leal VNC, Genov IR, Mallozi MC, Sol\u00e9 D, Pontillo A.
Mol Immunol. 2018 Jan;93:64-67. doi: 10.1016\/j.molimm.2017.11.006. Epub 2017 Nov 15.<\/p>\n

Cancer cells induce interleukin-22 production from memory CD4+<\/sub>\u00a0T cells via interleukin-1 to promote tumor growth.
<\/a>Voigt C, May P, Gottschlich A, Markota A, Wenk D, Gerlach I, Voigt S, Stathopoulos GT, Arendt KAM, Heise C, Rataj F, Janssen KP, K\u00f6nigshoff M, Winter H, Himsl I, Thasler WE, Schnurr M, Rothenfu\u00dfer S, Endres S, Kobold S.
Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12994-12999. doi: 10.1073\/pnas.1705165114. Epub 2017 Nov 17.<\/p>\n

Ly6G+ neutrophil-derived miR-223 inhibits the\u00a0NLRP3\u00a0inflammasome in mitochondrial DAMP-induced acute\u00a0lung\u00a0injury.
<\/a>Feng Z, Qi S, Zhang Y, Qi Z, Yan L, Zhou J, He F, Li Q, Yang Y, Chen Q, Xiao S, Li Q, Chen Y, Zhang Y.
Cell Death Dis. 2017 Nov 16;8(11):e3170. doi: 10.1038\/cddis.2017.549.<\/p>\n

Role of the inflammasome in chronic obstructive pulmonary\u00a0disease\u00a0(COPD).
<\/a>Colarusso C, Terlizzi M, Molino A, Pinto A, Sorrentino R.
Oncotarget. 2017 May 13;8(47):81813-81824. doi: 10.18632\/oncotarget.17850. eCollection 2017 Oct 10.<\/p>\n

Mitochondria Targeted Peptide Attenuates Mitochondrial Dysfunction, Controls Inflammation and Protects Against Spinal Cord Injury-Induced\u00a0Lung\u00a0Injury.
<\/a>Zhu LL, Li MQ, He F, Zhou SB, Jiang W.
Cell Physiol Biochem. 2017;44(1):388-400. doi: 10.1159\/000484919. Epub 2017 Nov 13.<\/p>\n

Polymeric Nanoparticles Induce\u00a0NLRP3\u00a0Inflammasome Activation and Promote Breast Cancer Metastasis.
<\/a>Hu Q, Zhao F, Guo F, Wang C, Fu Z.
Macromol Biosci. 2017 Dec;17(12). doi: 10.1002\/mabi.201700273. Epub 2017 Nov 13.<\/p>\n

[NLRP3\u00a0inflammasome induces pyroptosis in\u00a0lung\u00a0tissues of radiation-induced\u00a0lung\u00a0injury in mice].
<\/a>Han R, Wu D, Deng S, Liu T, Zhang T, Xu Y.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Sep;33(9):1206-1211. Chinese.<\/p>\n

NLRP3\u00a0Inflammasome Activation Contributes to Mechanical Stretch-Induced Endothelial-Mesenchymal Transition and Pulmonary Fibrosis.
<\/a>Lv Z, Wang Y, Liu YJ, Mao YF, Dong WW, Ding ZN, Meng GX, Jiang L, Zhu XY.
Crit Care Med. 2018 Jan;46(1):e49-e58. doi: 10.1097\/CCM.0000000000002799.<\/p>\n

Mir-21 Mediates the Inhibitory Effect of Ang (1-7) on AngII-induced\u00a0NLRP3\u00a0Inflammasome Activation by Targeting Spry1 in\u00a0lung\u00a0fibroblasts.
<\/a>Sun NN, Yu CH, Pan MX, Zhang Y, Zheng BJ, Yang QJ, Zheng ZM, Meng Y.
Sci Rep. 2017 Oct 30;7(1):14369. doi: 10.1038\/s41598-017-13305-3.<\/p>\n

[Significance of the\u00a0NLRP3\u00a0inflammasome expression in rats with acute\u00a0lung\u00a0injury induced by phosgene].
<\/a>He DK, Shao YR, Shen J, Zhang L, Zhang J, Zhang F.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2017 Jul 20;35(7):491-496. doi: 10.3760\/cma.j.issn.1001-9391.2017.07.004. Chinese.<\/p>\n

Neutrophils drive alveolar macrophage IL-1\u03b2 release during respiratory viral infection.
<\/a>Peir\u00f3 T, Patel DF, Akthar S, Gregory LG, Pyle CJ, Harker JA, Birrell MA, Lloyd CM, Snelgrove RJ.
Thorax. 2018 Jun;73(6):546-556. doi: 10.1136\/thoraxjnl-2017-210010. Epub 2017 Oct 27.<\/p>\n

NLRP3\u00a0Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection.
<\/a>Segovia JA, Chang TH, Winter VT, Coalson JJ, Cagle MP, Pandranki L, Bose S, Baseman JB, Kannan TR.
Infect Immun. 2017 Dec 19;86(1). pii: e00548-17. doi: 10.1128\/IAI.00548-17. Print 2018 Jan<\/p>\n

Protective effect of cinnamic acid in endotoxin-poisoned mice.
<\/a>Xu F, Wang F, Wen T, Sang W, He X, Li L, Zeng N.
Phytother Res. 2017 Dec;31(12):1946-1953. doi: 10.1002\/ptr.5944. Epub 2017 Oct 11.<\/p>\n

Saikosaponin a Ameliorates LPS-Induced Acute\u00a0Lung\u00a0Injury in Mice.
<\/a>Du ZA, Sun MN, Hu ZS.
Inflammation. 2018 Feb;41(1):193-198. doi: 10.1007\/s10753-017-0677-3.<\/p>\n

ASC and\u00a0NLRP3\u00a0impair host defense during lethal pneumonia caused by serotype 3 Streptococcus pneumoniae in mice.
<\/a>van Lieshout MHP, de Vos AF, Dessing MC, de Porto APNA, de Boer OJ, de Beer R, Terpstra S, Florquin S, Van’t Veer C, van der Poll T.
Eur J Immunol. 2018 Jan;48(1):66-79. doi: 10.1002\/eji.201646554. Epub 2017 Nov 3.<\/p>\n

Length, but Not Reactive Edges, of Cup-stack MWCNT Is Responsible for Toxicity and Acute\u00a0LungInflammation.
<\/a>Hamilton RF Jr, Tsuruoka S, Wu N, Wolfarth M, Porter DW, Bunderson-Schelvan M, Holian A.
Toxicol Pathol. 2018 Jan;46(1):62-74. doi: 10.1177\/0192623317732303. Epub 2017 Sep 25.<\/p>\n

Caspase-11 deficiency impairs neutrophil recruitment and bacterial clearance in the early stage of pulmonary Klebsiella pneumoniae infection.
<\/a>Wang J, Shao Y, Wang W, Li S, Xin N, Xie F, Zhao C.
Int J Med Microbiol. 2017 Dec;307(8):490-496. doi: 10.1016\/j.ijmm.2017.09.012. Epub 2017 Sep 12.<\/p>\n

Calcitonin gene-related peptide exerts anti-inflammatory property through regulating murine macrophages polarization in vitro.
<\/a>Duan JX, Zhou Y, Zhou AY, Guan XX, Liu T, Yang HH, Xie H, Chen P.
Mol Immunol. 2017 Nov;91:105-113. doi: 10.1016\/j.molimm.2017.08.020. Epub 2017 Sep 8.<\/p>\n

Dexmedetomidine Alleviates Hyperoxia-Induced Acute\u00a0Lung\u00a0Injury via Inhibiting\u00a0NLRP3Inflammasome Activation.
<\/a>Zhang Q, Wu D, Yang Y, Liu T, Liu H.
Cell Physiol Biochem. 2017;42(5):1907-1919. doi: 10.1159\/000479609. Epub 2017 Aug 3.<\/p>\n

Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model: a translational study.
<\/a>Spengler D, Winoto-Morbach S, Kupsch S, Vock C, Bl\u00f6chle K, Frank S, Rintz N, Diek\u00f6tter M, Janga H, Weckmann M, Fuchs S, Schromm AB, Fehrenbach H, Sch\u00fctze S, Krause MF.
Am J Physiol\u00a0Lung\u00a0Cell Mol Physiol. 2018 Jan 1;314(1):L32-L53. doi: 10.1152\/ajplung.00128.2017. Epub 2017 Aug 31.<\/p>\n

Effect of interleukin-1\u03b2 inhibition with canakinumab on incident\u00a0lung\u00a0cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial.
<\/a>Ridker PM, MacFadyen JG, Thuren T, Everett BM, Libby P, Glynn RJ; CANTOS Trial Group.
Lancet. 2017 Oct 21;390(10105):1833-1842. doi: 10.1016\/S0140-6736(17)32247-X. Epub 2017 Aug 27.<\/p>\n

Alcohol abuse is associated with enhanced pulmonary and systemic xanthine oxidoreductase activity.
<\/a>Fini MA, Gaydos J, McNally A, Karoor V, Burnham EL.
Am J Physiol\u00a0Lung\u00a0Cell Mol Physiol. 2017 Dec 1;313(6):L1047-L1057. doi: 10.1152\/ajplung.00570.2016. Epub 2017 Aug 24.<\/p>\n

The activation of\u00a0NLRP3-inflammsome by stimulation of diesel exhaust particles in\u00a0lung\u00a0tissues from emphysema model and RAW 264.7 cell line.
<\/a>Uh ST, Koo SM, Kim Y, Kim K, Park S, Jang AS, Kim D, Kim YH, Park CS.<\/p>\n

Digitoflavone (DG) attenuates LPS-induced acute\u00a0lung\u00a0injury through reducing oxidative stress and inflammatory response dependent on the suppression of TXNIP\/NLRP3\u00a0and NF-\u03baB.
<\/a>Meng M.
Biomed Pharmacother. 2017 Oct;94:712-725. doi: 10.1016\/j.biopha.2017.07.001. Epub 2017 Aug<\/p>\n

Inhibition of\u00a0NLRP3\u00a0inflammasome: a new protective mechanism of cinnamaldehyde in endotoxin poisoning of mice.
<\/a>Xu F, Wang F, Wen T, Sang W, Wang D, Zeng N.
Immunopharmacol Immunotoxicol. 2017 Oct;39(5):296-304. doi: 10.1080\/08923973.2017.1355377. Epub 2017 Aug 1.<\/p>\n

[The Effect of Sodium Ferulate in Experimental Pulmonary Fibrosis via NALP3 Inflammasome].
<\/a>Kuang J, Wei XL, Xie M.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 Jul;48(4):503-508. Chinese.<\/p>\n

A synthetic cationic antimicrobial peptide inhibits inflammatory response and the\u00a0NLRP3inflammasome by neutralizing LPS and ATP.
<\/a>Li LH, Ju TC, Hsieh CY, Dong WC, Chen WT, Hua KF, Chen WJ.
PLoS One. 2017 Jul 27;12(7):e0182057. doi: 10.1371\/journal.pone.0182057. eCollection 2017.<\/p>\n

Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection.
<\/a>Coates BM, Staricha KL, Ravindran N, Koch CM, Cheng Y, Davis JM, Shumaker DK, Ridge KM.
Front Immunol. 2017 Jul 10;8:782. doi: 10.3389\/fimmu.2017.00782. eCollection 2017.<\/p>\n

Macrolides protect against\u00a0Pseudomonas aeruginosa<\/em>\u00a0infection via inhibition of inflammasomes.
<\/a>Fan LC, Lin JL, Yang JW, Mao B, Lu HW, Ge BX, Choi AMK, Xu JF.
Am J Physiol\u00a0Lung\u00a0Cell Mol Physiol. 2017 Oct 1;313(4):L677-L686. doi: 10.1152\/ajplung.00123.2017. Epub 2017 Jul 6.<\/p>\n

MD-2 regulates LPS-induced\u00a0NLRP3\u00a0inflammasome activation and IL-1beta secretion by a MyD88\/NF-\u03baB-dependent pathway in alveolar macrophages cell line.
<\/a>Luo M, Hu L, Li D, Wang Y, He Y, Zhu L, Ren W.
Mol Immunol. 2017 Oct;90:1-10. doi: 10.1016\/j.molimm.2017.06.035. Epub 2017 Jun 24.<\/p>\n

Role of P2X7<\/sub>R in the development and progression of pulmonary hypertension.
<\/a>Yin J, You S, Liu H, Chen L, Zhang C, Hu H, Xue M, Cheng W, Wang Y, Li X, Shi Y, Li N, Yan S, Li X.
Respir Res. 2017 Jun 24;18(1):127. doi: 10.1186\/s12931-017-0603-0.<\/p>\n

NLRP3\u00a0inflammasome pathway has a critical role in the host immunity against clinically relevant Acinetobacter baumannii pulmonary infection.
<\/a>Dikshit N, Kale SD, Khameneh HJ, Balamuralidhar V, Tang CY, Kumar P, Lim TP, Tan TT, Kwa AL, Mortellaro A, Sukumaran B.
Mucosal Immunol. 2018 Jan;11(1):257-272. doi: 10.1038\/mi.2017.50. Epub 2017 Jun 14.<\/p>\n

MiR-20b inhibits mycobacterium tuberculosis induced inflammation in the\u00a0lung\u00a0of mice through targeting\u00a0NLRP3.
<\/a>Lou J, Wang Y, Zhang Z, Qiu W.
Exp Cell Res. 2017 Sep 15;358(2):120-128. doi: 10.1016\/j.yexcr.2017.06.007. Epub 2017 Jun 10.<\/p>\n

[Sodium Ferulate Attenuates Oxidative Stressvia Suppressing NALP3 Inflammasome and ERK Signal Pathway].
<\/a>Wei XL, Xie M, He GY.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2016 Sep;47(5):655-659. Chinese.<\/p>\n

NLRP3\u00a0participates in the regulation of EMT in bleomycin-induced pulmonary fibrosis.
<\/a>Tian R, Zhu Y, Yao J, Meng X, Wang J, Xie H, Wang R.
Exp Cell Res. 2017 Aug 15;357(2):328-334. doi: 10.1016\/j.yexcr.2017.05.028. Epub 2017 Jun 4.<\/p>\n

Pyrin-only protein 2 limits inflammation but improves protection against bacteria
<\/a>Periasamy S, Porter KA, Atianand MK, T Le H, Earley S, Duffy EB, Haller MC, Chin H, Harton JA.
Nat Commun. 2017 Jun 5;8:15564. doi: 10.1038\/ncomms15564.<\/p>\n

IL-18 cleavage triggers cardiac inflammation and fibrosis upon \u03b2-adrenergic insult.
<\/a>Xiao H, Li H, Wang JJ, Zhang JS, Shen J, An XB, Zhang CC, Wu JM, Song Y, Wang XY, Yu HY, Deng XN, Li ZJ, Xu M, Lu ZZ, Du J, Gao W, Zhang AH, Feng Y, Zhang YY.
Eur Heart J. 2018 Jan 1;39(1):60-69. doi: 10.1093\/eurheartj\/ehx261.<\/p>\n

Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.
<\/a>Rossios C, Pavlidis S, Hoda U, Kuo CH, Wiegman C, Russell K, Sun K, Loza MJ, Baribaud F, Durham AL, Ojo O, Lutter R, Rowe A, Bansal A, Auffray C, Sousa A, Corfield J, Djukanovic R, Guo Y, Sterk PJ, Chung KF, Adcock IM; Unbiased Biomarkers for the Prediction of Respiratory\u00a0Diseases\u00a0Outcomes (U-BIOPRED) Consortia Project Team.
J Allergy Clin Immunol. 2018 Feb;141(2):560-570. doi: 10.1016\/j.jaci.2017.02.045. Epub 2017 May 18.<\/p>\n

Salidroside Attenuates Ventilation Induced\u00a0Lung\u00a0Injury via SIRT1-Dependent Inhibition of\u00a0NLRP3Inflammasome.
<\/a>Wang Y, Xu CF, Liu YJ, Mao YF, Lv Z, Li SY, Zhu XY, Jiang L.
Cell Physiol Biochem. 2017;42(1):34-43. doi: 10.1159\/000477112. Epub 2017 May 10.<\/p>\n

Therapeutic effects of silibinin on LPS-induced acute\u00a0lung\u00a0injury by inhibiting\u00a0NLRP3\u00a0and NF-\u03baB signaling pathways.
<\/a>Tian L, Li W, Wang T.
Microb Pathog. 2017 Jul;108:104-108. doi: 10.1016\/j.micpath.2017.05.011. Epub 2017 May 5.<\/p>\n

Human Plasma Thioredoxin-80 Increases With Age and in ApoE-\/-<\/sub>\u00a0Mice Induces Inflammation, Angiogenesis, and Atherosclerosis.
<\/a>Couchie D, Vaisman B, Abderrazak A, Mahmood DFD, Hamza MM, Canesi F, Diderot V, El Hadri K, N\u00e8gre-Salvayre A, Le Page A, Fulop T, Remaley AT, Rouis M.
Circulation. 2017 Aug 1;136(5):464-475. doi: 10.1161\/CIRCULATIONAHA.117.027612. Epub 2017 May 4.<\/p>\n

Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the\u00a0NLRP3inflammasome.
<\/a>Hoyt LR, Randall MJ, Ather JL, DePuccio DP, Landry CC, Qian X, Janssen-Heininger YM, van der Vliet A, Dixon AE, Amiel E, Poynter ME.
Redox Biol. 2017 Aug;12:883-896. doi: 10.1016\/j.redox.2017.04.020. Epub 2017 Apr 25.<\/p>\n

Inhibition of inflammasome activation improves\u00a0lung\u00a0acute injury induced by carrageenan in a mouse model of pleurisy.
<\/a>Fusco R, Gugliandolo E, Biundo F, Campolo M, Di Paola R, Cuzzocrea S.
FASEB J. 2017 Aug;31(8):3497-3511. doi: 10.1096\/fj.201601349R. Epub 2017 May 1.<\/p>\n

LFG-500, a novel synthetic flavonoid, suppresses epithelial-mesenchymal transition in human\u00a0lungadenocarcinoma cells by inhibiting\u00a0NLRP3\u00a0in inflammatory microenvironment.
<\/a>Yang D, Cao X, Wang F, Jiang H, Feng D, Guo H, Du L, Jin Y, Chen Y, Yin X, Li C.
Cancer Lett. 2017 Aug 1;400:137-148. doi: 10.1016\/j.canlet.2017.04.035. Epub 2017 Apr 29.<\/p>\n

Colchicine Improves Survival, Left Ventricular Remodeling, and Chronic Cardiac Function After Acute Myocardial Infarction.
<\/a>Fujisue K, Sugamura K, Kurokawa H, Matsubara J, Ishii M, Izumiya Y, Kaikita K, Sugiyama S.
Circ J. 2017 Jul 25;81(8):1174-1182. doi: 10.1253\/circj.CJ-16-0949. Epub 2017 Apr 18.<\/p>\n

NLRP3\u00a0inflammasome induced liver graft injury through activation of telomere-independent RAP1\/KC axis.
<\/a>Liu H, Lo CM, Yeung OWH, Li CX, Liu XB, Qi X, Ng KTP, Liu J, Ma YY, Lam YF, Lian Q, Chan SC, Man K.
J Pathol. 2017 Jul;242(3):284-296. doi: 10.1002\/path.4901. Epub 2017 May 15.<\/p>\n

Target practice in severe asthma.
<\/a>Christenson SA.
Sci Transl Med. 2017 Mar 29;9(383). pii: eaan0769. doi: 10.1126\/scitranslmed.aan0769.<\/p>\n

Silybin attenuates LPS-induced\u00a0lung\u00a0injury in mice by inhibiting NF-\u03baB signaling and\u00a0NLRP3activation.
<\/a>Zhang B, Wang B, Cao S, Wang Y, Wu D.
Int J Mol Med. 2017 May;39(5):1111-1118. doi: 10.3892\/ijmm.2017.2935. Epub 2017 Mar 27.<\/p>\n

Follistatin like-1 aggravates silica-induced mouse\u00a0lung\u00a0injury.
<\/a>Fang Y, Zhang S, Li X, Jiang F, Ye Q, Ning W.
Sci Rep. 2017 Mar 24;7(1):399. doi: 10.1038\/s41598-017-00478-0.<\/p>\n

Asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (BLM) via suppressing pro-fibrotic and inflammatory signaling pathways.
<\/a>Dong SH, Liu YW, Wei F, Tan HZ, Han ZD.
Biomed Pharmacother. 2017 May;89:1297-1309. doi: 10.1016\/j.biopha.2017.03.005. Epub 2017 Mar 17.<\/p>\n

[Mechanism of angiotensin-converting enzyme 2 overexpression improving collagen synthesis in\u00a0lung].
<\/a>Yang QJ, Zheng BB, Sun NN, Pan MX, Zheng ZM, Meng Y.
Zhonghua Yi Xue Za Zhi. 2017 Mar 14;97(10):770-776. doi: 10.3760\/cma.j.issn.0376-2491.2017.10.011. Chinese.<\/p>\n

Protective Effect of Amygdalin on LPS-Induced Acute\u00a0Lung\u00a0Injury by Inhibiting NF-\u03baB and\u00a0NLRP3Signaling Pathways.
<\/a>Zhang A, Pan W, Lv J, Wu H.
Inflammation. 2017 Jun;40(3):745-751. doi: 10.1007\/s10753-017-0518-4.<\/p>\n

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute\u00a0lung\u00a0injury via induction of AMPK\/GSK3\u03b2-Nrf2 signal axis.
<\/a>Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X.
Redox Biol. 2017 Aug;12:311-324. doi: 10.1016\/j.redox.2017.03.001. Epub 2017 Mar 2.<\/p>\n

The acute airway inflammation induced by PM2.5<\/sub>\u00a0exposure and the treatment of essential oils in Balb\/c mice.
<\/a>Wang H, Song L, Ju W, Wang X, Dong L, Zhang Y, Ya P, Yang C, Li F.
Sci Rep. 2017 Mar 9;7:44256. doi: 10.1038\/srep44256.<\/p>\n

Nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic\u00a0lung diseases.
<\/a>Hodge S, Tran HB, Hamon R, Roscioli E, Hodge G, Jersmann H, Ween M, Reynolds PN, Yeung A, Treiberg J, Wilbert S.
Am J Physiol\u00a0Lung\u00a0Cell Mol Physiol. 2017 May 1;312(5):L678-L687. doi: 10.1152\/ajplung.00518.2016. Epub 2017 Mar 3.<\/p>\n

Role for\u00a0NLRP3\u00a0Inflammasome-mediated, IL-1\u03b2-Dependent Responses in Severe, Steroid-Resistant Asthma.
<\/a>Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, Hirota JA, Wood LG, Simpson JL, Knight DA, Wark PA, Gibson PG, O’Neill LAJ, Cooper MA, Horvat JC, Hansbro PM.
Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297. doi: 10.1164\/rccm.201609-1830OC.<\/p>\n

Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma.
<\/a>Sebag SC, Koval OM, Paschke JD, Winters CJ, Jaffer OA, Dworski R, Sutterwala FS, Anderson ME, Grumbach IM.
JCI Insight. 2017 Feb 9;2(3):e88297. doi: 10.1172\/jci.insight.88297.<\/p>\n

The protective effect of dopamine on ventilator-induced\u00a0lung\u00a0injury via the inhibition of\u00a0NLRP3inflammasome.
<\/a>Yang X, Sun X, Chen H, Xi G, Hou Y, Wu J, Liu D, Wang H, Hou Y, Yu J.
Int Immunopharmacol. 2017 Apr;45:68-73. doi: 10.1016\/j.intimp.2017.02.002. Epub 2017 Feb 8.<\/p>\n

Inflammasomes in the\u00a0lung.
<\/a>Pinkerton JW, Kim RY, Robertson AAB, Hirota JA, Wood LG, Knight DA, Cooper MA, O’Neill LAJ, Horvat JC, Hansbro PM.
Mol Immunol. 2017 Jun;86:44-55. doi: 10.1016\/j.molimm.2017.01.014. Epub 2017 Jan 24. Review.<\/p>\n

Phagolysosome acidification is required for silica and engineered nanoparticle-induced lysosome membrane permeabilization and resultant\u00a0NLRP3\u00a0inflammasome activity.
<\/a>Jessop F, Hamilton RF Jr, Rhoderick JF, Fletcher P, Holian A.
Toxicol Appl Pharmacol. 2017 Mar 1;318:58-68. doi: 10.1016\/j.taap.2017.01.012. Epub 2017 Jan 24.<\/p>\n

Neutrophilic\u00a0NLRP3\u00a0inflammasome-dependent IL-1\u03b2 secretion regulates the \u03b3\u03b4T17 cell response in respiratory bacterial infections.
<\/a>Hassane M, Demon D, Soulard D, Fontaine J, Keller LE, Patin EC, Porte R, Prinz I, Ryffel B, Kadioglu A, Veening JW, Sirard JC, Faveeuw C, Lamkanfi M, Trottein F, Paget C.
Mucosal Immunol. 2017 Jul;10(4):1056-1068. doi: 10.1038\/mi.2016.113. Epub 2017 Jan 4.<\/p>\n

NLRP3\u00a0inflammasome mediates interleukin-1\u03b2 production in immune cells in response to Acinetobacter baumannii and contributes to pulmonary inflammation in mice.
<\/a>Kang MJ, Jo SG, Kim DJ, Park JH.
Immunology. 2017 Apr;150(4):495-505. doi: 10.1111\/imm.12704. Epub 2017 Jan 30.<\/p>\n

Deletion of\u00a0Nlrp3\u00a0Augments Survival during Polymicrobial Sepsis by Decreasing Autophagy and Enhancing Phagocytosis.
<\/a>Jin L, Batra S, Jeyaseelan S.
J Immunol. 2017 Feb 1;198(3):1253-1262. doi: 10.4049\/jimmunol.1601745. Epub 2016 Dec 28.<\/p>\n

Blocking triggering receptor expressed on myeloid cells-1 attenuates lipopolysaccharide-induced acute\u00a0lung\u00a0injury via inhibiting\u00a0NLRP3\u00a0inflammasome activation.
<\/a>Liu T, Zhou Y, Li P, Duan JX, Liu YP, Sun GY, Wan L, Dong L, Fang X, Jiang JX, Guan CX.
Sci Rep. 2016 Dec 22;6:39473. doi: 10.1038\/srep39473.<\/p>\n

The role of caloric load and mitochondrial homeostasis in the regulation of the\u00a0NLRP3\u00a0inflammasome.
<\/a>Traba J, Sack MN.
Cell Mol Life Sci. 2017 May;74(10):1777-1791. doi: 10.1007\/s00018-016-2431-7. Epub 2016 Dec 10. Review.<\/p>\n

Inflammasome-Independent\u00a0NLRP3\u00a0Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia.
<\/a>Periasamy S, Le HT, Duffy EB, Chin H, Harton JA.
PLoS Pathog. 2016 Dec 7;12(12):e1006059. doi: 10.1371\/journal.ppat.1006059. eCollection 2016 Dec.<\/p>\n

PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the\u00a0NLRP3\u00a0Inflammasome.
<\/a>Pinar A, Dowling JK, Bitto NJ, Robertson AA, Latz E, Stewart CR, Drummond GR, Cooper MA, McAuley JL, Tate MD, Mansell A.
J Biol Chem. 2017 Jan 20;292(3):826-836. doi: 10.1074\/jbc.M116.756379. Epub 2016 Dec 2.<\/p>\n

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.
<\/a>Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E.
PLoS Pathog. 2016 Dec 2;12(12):e1006035. doi: 10.1371\/journal.ppat.1006035. eCollection 2016 Dec.<\/p>\n

Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-\u03b3 via DAPK1.
<\/a>Oikonomou V, Moretti S, Renga G, Galosi C, Borghi M, Pariano M, Puccetti M, Palmerini CA, Amico L, Carotti A, Prezioso L, Spolzino A, Finocchi A, Rossi P, Velardi A, Aversa F, Napolioni V, Romani L.
Cell Host Microbe. 2016 Dec 14;20(6):744-757. doi: 10.1016\/j.chom.2016.10.012. Epub 2016 Nov 23.<\/p>\n

Purinergic receptors: new targets for the treatment of gout and fibrosis.
<\/a>Gicquel T, Le Dar\u00e9 B, Boichot E, Lagente V.
Fundam Clin Pharmacol. 2017 Apr;31(2):136-146. doi: 10.1111\/fcp.12256. Epub 2016 Dec 30. Review.<\/p>\n

17-oxo-DHA displays additive anti-inflammatory effects with fluticasone propionate and inhibits the\u00a0NLRP3\u00a0inflammasome.
<\/a>Cipollina C, Di Vincenzo S, Siena L, Di Sano C, Gjomarkaj M, Pace E.
Sci Rep. 2016 Nov 24;6:37625. doi: 10.1038\/srep37625.<\/p>\n

P2rx4 deficiency in mice alleviates allergen-induced airway inflammation.
<\/a>Zech A, Wiesler B, Ayata CK, Schlaich T, D\u00fcrk T, Ho\u00dffeld M, Ehrat N, Cicko S, Idzko M.
Oncotarget. 2016 Dec 6;7(49):80288-80297. doi: 10.18632\/oncotarget.13375.<\/p>\n

Dopamine D1 receptor agonist A-68930 inhibits\u00a0NLRP3\u00a0inflammasome activation and protects rats from spinal cord injury-induced acute\u00a0lung\u00a0injury.
<\/a>Jiang W, Li M, He F, Bian Z, Liu J, He Q, Wang X, Sun T, Zhu L.
Spinal Cord. 2016 Nov;54(11):951-956. doi: 10.1038\/sc.2016.52. Epub 2016 Apr 12.<\/p>\n

Andrographolide ameliorates OVA-induced\u00a0lung\u00a0injury in mice by suppressing ROS-mediated NF-\u03baB signaling and\u00a0NLRP3\u00a0inflammasome activation.
<\/a>Peng S, Gao J, Liu W, Jiang C, Yang X, Sun Y, Guo W, Xu Q.
Oncotarget. 2016 Dec 6;7(49):80262-80274. doi: 10.18632\/oncotarget.12918.<\/p>\n

Liraglutide attenuates lipopolysaccharide-induced acute\u00a0lung\u00a0injury in mice.
<\/a>Zhou F, Zhang Y, Chen J, Hu X, Xu Y.
Eur J Pharmacol. 2016 Nov 15;791:735-740. doi: 10.1016\/j.ejphar.2016.10.016. Epub 2016 Oct 15.<\/p>\n

Targeting inflammasome\/IL-1 pathways for cancer immunotherapy.
<\/a>Guo B, Fu S, Zhang J, Liu B, Li Z.
Sci Rep. 2016 Oct 27;6:36107. doi: 10.1038\/srep36107.<\/p>\n

Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1\u03b2\/IL-1R1\/MyD88\/NF-\u03baB pathway.
<\/a>Song C, He L, Zhang J, Ma H, Yuan X, Hu G, Tao L, Zhang J, Meng J.
J Cell Mol Med. 2016 Nov;20(11):2064-2077. doi: 10.1111\/jcmm.12898. Epub 2016 Jun 16.<\/p>\n

The inflammasome pathway in stable COPD and acute exacerbations.
<\/a>Faner R, Sobradillo P, Noguera A, Gomez C, Cruz T, L\u00f3pez-Giraldo A, Ballester E, Soler N, Arostegui JI, Pelegr\u00edn P, Rodriguez-Roisin R, Yag\u00fce J, Cosio BG, Juan M, Agust\u00ed A.
ERJ Open Res. 2016 Jul 11;2(3). pii: 00002-2016. eCollection 2016 Jul.<\/p>\n

Hero turned villain:\u00a0NLRP3\u00a0inflammasome-induced inflammation during influenza A virus infection.
<\/a>Ong JD, Mansell A, Tate MD.
J Leukoc Biol. 2017 Apr;101(4):863-874. doi: 10.1189\/jlb.4MR0616-288R. Epub 2016 Oct 5. Review.<\/p>\n

Increased neutrophil expression of pattern recognition receptors during COPD exacerbations.
<\/a>Pouwels SD, van Geffen WH, Jonker MR, Kerstjens HA, Nawijn MC, Heijink IH.
Respirology. 2017 Feb;22(2):401-404. doi: 10.1111\/resp.12912. Epub 2016 Sep 27.<\/p>\n

The\u00a0NLRP3\u00a0inflammasome in pathogenic particle and fibre-associated\u00a0lung\u00a0inflammation and\u00a0diseases.
<\/a>Sayan M, Mossman BT.
Part Fibre Toxicol. 2016 Sep 20;13(1):51. doi: 10.1186\/s12989-016-0162-4. Review.<\/p>\n

Resveratrol ameliorates LPS-induced acute\u00a0lung\u00a0injury via\u00a0NLRP3\u00a0inflammasome modulation.
<\/a>Jiang L, Zhang L, Kang K, Fei D, Gong R, Cao Y, Pan S, Zhao M, Zhao M.
Pharmacother. 2016 Dec;84:130-138. doi: 10.1016\/j.biopha.2016.09.020. Epub 2016 Sep 16.<\/p>\n

Therapeutic effect of methyl salicylate 2-O-\u03b2-d-lactoside on LPS-induced acute\u00a0lung\u00a0injury by inhibiting TAK1\/NF-kappaB phosphorylation and\u00a0NLRP3\u00a0expression.
<\/a>Yang S, Yu Z, Yuan T, Wang L, Wang X, Yang H, Sun L, Wang Y, Du G.
Int Immunopharmacol. 2016 Nov;40:219-228. doi: 10.1016\/j.intimp.2016.08.041. Epub 2016 Sep 9.<\/p>\n

Hemorrhagic shock primes for\u00a0lung\u00a0vascular endothelial cell pyroptosis: role in pulmonary inflammation following LPS.
<\/a>Yang J, Zhao Y, Zhang P, Li Y, Yang Y, Yang Y, Zhu J, Song X, Jiang G, Fan J.
Cell Death Dis. 2016 Sep 8;7(9):e2363. doi: 10.1038\/cddis.2016.274.<\/p>\n

Protective Effects of Asiatic Acid Against Spinal Cord Injury-Induced Acute\u00a0Lung\u00a0Injury in Rats.
<\/a>Jiang W, Li M, He F, Yao W, Bian Z, Wang X, Zhu L.
Inflammation. 2016 Dec;39(6):1853-1861.<\/p>\n

Autophagy deficiency in macrophages enhances\u00a0NLRP3\u00a0inflammasome activity and chronic\u00a0lung disease\u00a0following silica exposure.
<\/a>Jessop F, Hamilton RF, Rhoderick JF, Shaw PK, Holian A.
Toxicol Appl Pharmacol. 2016 Oct 15;309:101-10. doi: 10.1016\/j.taap.2016.08.029. Epub 2016 Sep 1.<\/p>\n

Neutrophil pyroptosis mediates pathology of P. aeruginosa\u00a0lung\u00a0infection in the absence of the NADPH oxidase NOX2.
<\/a>Ryu JC, Kim MJ, Kwon Y, Oh JH, Yoon SS, Shin SJ, Yoon JH, Ryu JH.
Mucosal Immunol. 2017 May;10(3):757-774. doi: 10.1038\/mi.2016.73. Epub 2016 Aug 24.<\/p>\n

Original Rearch: Evaluation of pulmonary response to inhaled tungsten (IV) oxide nanoparticles in golden Syrian hamsters.
<\/a>Prajapati MV, Adebolu OO, Morrow BM, Cerreta JM.
Exp Biol Med (Maywood). 2017 Jan;242(1):29-44. Epub 2016 Aug 17.<\/p>\n

IL-1\u03b1 and IL-1\u03b2-producing macrophages populate\u00a0lung\u00a0tumor lesions in mice.
<\/a>Terlizzi M, Colarusso C, Popolo A, Pinto A, Sorrentino R.
Oncotarget. 2016 Sep 6;7(36):58181-58192. doi: 10.18632\/oncotarget.11276.<\/p>\n

TLR4-Upregulated IL-1\u03b2 and IL-1RI Promote Alveolar Macrophage Pyroptosis and\u00a0Lung\u00a0Inflammation through an Autocrine Mechanism.
<\/a>He X, Qian Y, Li Z, Fan EK, Li Y, Wu L, Billiar TR, Wilson MA, Shi X, Fan J.
Sci Rep. 2016 Aug 16;6:31663. doi: 10.1038\/srep31663.<\/p>\n

Exposure to nickel oxide nanoparticles induces pulmonary inflammation through\u00a0NLRP3inflammasome activation in rats.
<\/a>Cao Z, Fang Y, Lu Y, Qian F, Ma Q, He M, Pi H, Yu Z, Zhou Z.
Int J Nanomedicine. 2016 Jul 22;11:3331-46. doi: 10.2147\/IJN.S106912. eCollection 2016.<\/p>\n

Efficacy and Pharmacology of the\u00a0NLRP3\u00a0Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
<\/a>Primiano MJ, Lefker BA, Bowman MR, Bree AG, Hubeau C, Bonin PD, Mangan M, Dower K, Monks BG, Cushing L, Wang S, Guzova J, Jiao A, Lin LL, Latz E, Hepworth D, Hall JP.
J Immunol. 2016 Sep 15;197(6):2421-33. doi: 10.4049\/jimmunol.1600035. Epub 2016 Aug 12.<\/p>\n

NLRP3\u00a0protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence.
<\/a>Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B.
Sci Rep. 2016 Aug 1;6:30943. doi: 10.1038\/srep30943.<\/p>\n

Role of Canonical and Non-canonical Inflammasomes During Burkholderia Infection.
<\/a>Sahoo M, Lantier L, Re F.
Curr Top Microbiol Immunol. 2016;397:199-214. doi: 10.1007\/978-3-319-41171-2_10. Review.<\/p>\n

Casticin inhibits lipopolysaccharide-induced acute\u00a0lung\u00a0injury in mice.
<\/a>Wang C, Zeng L, Zhang T, Liu J, Wang W.
Eur J Pharmacol. 2016 Oct 15;789:172-178. doi: 10.1016\/j.ejphar.2016.07.035. Epub 2016 Jul 21.<\/p>\n

The Nucleotide-Binding Oligomerization Domain-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome Regulates Bronchial Epithelial Cell Injury and Proapoptosis after Exposure to Biomass Fuel Smoke.
<\/a>Li C, Zhihong H, Wenlong L, Xiaoyan L, Qing C, Wenzhi L, Siming X, Shengming L.
Am J Respir Cell Mol Biol. 2016 Dec;55(6):815-824.<\/p>\n

Ethanol and Other Short-Chain Alcohols Inhibit\u00a0NLRP3\u00a0Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation.
<\/a>Hoyt LR, Ather JL, Randall MJ, DePuccio DP, Landry CC, Wewers MD, Gavrilin MA, Poynter ME.
J Immunol. 2016 Aug 15;197(4):1322-34. doi: 10.4049\/jimmunol.1600406. Epub 2016 Jul 15.<\/p>\n

CORM-2 inhibits TXNIP\/NLRP3\u00a0inflammasome pathway in LPS-induced acute\u00a0lung\u00a0injury.
<\/a>Jiang L, Fei D, Gong R, Yang W, Yu W, Pan S, Zhao M, Zhao M.
Inflamm Res. 2016 Nov;65(11):905-915. Epub 2016 Jul 13.<\/p>\n

Involvement of EGF receptor signaling and NLRP12 inflammasome in fine particulate matter-induced\u00a0lung\u00a0inflammation in mice.
<\/a>Jin Y, Wu W, Zhang W, Zhao Y, Wu Y, Ge G, Ba Y, Guo Q, Gao T, Chi X, Hao H, Wang J, Feng F.
Environ Toxicol. 2017 Apr;32(4):1121-1134. doi: 10.1002\/tox.22308. Epub 2016 Jul 5.<\/p>\n

High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation.
<\/a>Thacker SG, Zarzour A, Chen Y, Alcicek MS, Freeman LA, Sviridov DO, Demosky SJ Jr, Remaley AT.
Immunology. 2016 Nov;149(3):306-319. doi: 10.1111\/imm.12638. Epub 2016 Aug 28.<\/p>\n

T helper 1 immunity requires complement-driven\u00a0NLRP3\u00a0inflammasome activity in CD4\u207a T cells.
<\/a>Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O’Neill LA, Coll RC, Sher A, Leonard WJ, K\u00f6hl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C.
Science. 2016 Jun 17;352(6292):aad1210. doi: 10.1126\/science.aad1210.<\/p>\n

Reassessing the role of the\u00a0NLRP3\u00a0inflammasome during pathogenic influenza A virus infection via temporal inhibition.
<\/a>Tate MD, Ong JDH, Dowling JK, McAuley JL, Robertson AB, Latz E, Drummond GR, Cooper MA, Hertzog PJ, Mansell A.
Sci Rep. 2016 Jun 10;6:27912. doi: 10.1038\/srep27912.<\/p>\n

Genipin alleviates LPS-induced acute\u00a0lung\u00a0injury by inhibiting NF-\u03baB and\u00a0NLRP3\u00a0signaling pathways.
<\/a>Zhang A, Wang S, Zhang J, Wu H.
Int Immunopharmacol. 2016 Sep;38:115-9. doi: 10.1016\/j.intimp.2016.05.011. Epub 2016 Jun 2.<\/p>\n

Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis.
<\/a>Robert S, Gicquel T, Victoni T, Valen\u00e7a S, Barreto E, Bailly-Ma\u00eetre B, Boichot E, Lagente V.
Biosci Rep. 2016 Jul 15;36(4). pii: e00360. doi: 10.1042\/BSR20160107. Print 2016 Aug. Review.<\/p>\n

Cold-inducible RNA-binding protein causes endothelial dysfunction via activation of\u00a0Nlrp3inflammasome.
<\/a>Yang WL, Sharma A, Wang Z, Li Z, Fan J, Wang P.
Sci Rep. 2016 May 24;6:26571. doi: 10.1038\/srep26571.<\/p>\n

Endocytosis of indium-tin-oxide nanoparticles by macrophages provokes pyroptosis requiring\u00a0NLRP3-ASC-Caspase1 axis that can be prevented by mesenchymal stem cells.
<\/a>Naji A, Muzembo BA, Yagyu K, Baba N, Deschaseaux F, Senseb\u00e9 L, Suganuma N.
Sci Rep. 2016 May 19;6:26162. doi: 10.1038\/srep26162.<\/p>\n

Cytokine Profiles in Human Metapneumovirus Infected Children: Identification of Genes Involved in the Antiviral Response and Pathogenesis.
<\/a>Malmo J, Moe N, Krokstad S, Ryan L, Loevenich S, Johnsen IB, Espevik T, Nordb\u00f8 SA, D\u00f8llner H, Anthonsen MW.
PLoS One. 2016 May 12;11(5):e0155484. doi: 10.1371\/journal.pone.0155484. eCollection 2016.<\/p>\n

Inflammasome, IL-1 and inflammation in ozone-induced\u00a0lung\u00a0injury.
<\/a>Michaudel C, Couturier-Maillard A, Chenuet P, Maillet I, Mura C, Couillin I, Gombault A, Quesniaux VF, Huaux F, Ryffel B.
Am J Clin Exp Immunol. 2016 Mar 23;5(1):33-40. eCollection 2016. Review.<\/p>\n

[Role and mechanism of the NOD-like receptor 3 inflammasome in ventilator-induced\u00a0lung\u00a0injury in rats].
<\/a>Zhang W, Pan L.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Oct;27(10):821-5. Chinese.<\/p>\n

ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo.
<\/a>Kupz A, Zedler U, St\u00e4ber M, Perdomo C, Dorhoi A, Brosch R, Kaufmann SH.
J Clin Invest. 2016 Jun 1;126(6):2109-22. doi: 10.1172\/JCI84978. Epub 2016 Apr 25.<\/p>\n

Inflammasome genetics contributes to the development and control of active pulmonary tuberculosis.
<\/a>Souza de Lima D, Ogusku MM, Sadahiro A, Pontillo A.
Infect Genet Evol. 2016 Jul;41:240-244. doi: 10.1016\/j.meegid.2016.04.015. Epub 2016 Apr 19.<\/p>\n

[Effects of Serum Containing Qinbai Qinfei Concentrated Pellets on Expressions of\u00a0NLRP3Inflammasome in RAW264.7 Cells Infected with Mycoplasma pneumonia].
<\/a>Zhang H, Suo XB, Zhang YL, Ma J, Zhang SM, Xu QR, Wang WM.
Zhong Yao Cai. 2016 Apr;39(4):876-9. Chinese<\/p>\n

Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial Cells.
<\/a>Xi H, Zhang Y, Xu Y, Yang WY, Jiang X, Sha X, Cheng X, Wang J, Qin X, Yu J, Ji Y, Yang X, Wang H.
Circ Res. 2016 May 13;118(10):1525-39. doi: 10.1161\/CIRCRESAHA.116.308501. Epub 2016 Mar 22.<\/p>\n

T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.
<\/a>Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X.
Nat Immunol. 2016 May;17(5):583-92. doi: 10.1038\/ni.3389. Epub 2016 Mar 21.<\/p>\n

Antagonism of scavenger receptor CD36 by 5A\u00a0peptide prevents chronic kidney\u00a0disease\u00a0progression in mice independent of blood pressure\u00a0regulation.
<\/a>Souza AC, Bocharov AV, Baranova IN, Vishnyakova TG, Huang YG, Wilkins KJ, Hu X, Street JM, Alvarez-Prats A, Mullick AE, Patterson AP, Remaley AT, Eggerman TL, Yuen PS, Star RA.
Kidney Int. 2016 Apr;89(4):809-22. doi: 10.1016\/j.kint.2015.12.043.<\/p>\n

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis.
<\/a>Iannitti RG, Napolioni V, Oikonomou V, De Luca A, Galosi C, Pariano M, Massi-Benedetti C, Borghi M, Puccetti M, Lucidi V, Colombo C, Fiscarelli E, Lass-Fl\u00f6rl C, Majo F, Cariani L, Russo M, Porcaro L, Ricciotti G, Ellemunter H, Ratclif L, De Benedictis FM, Talesa VN, Dinarello CA, van de Veerdonk FL, Romani L.
Nat Commun. 2016 Mar 14;7:10791. doi: 10.1038\/ncomms10791.<\/p>\n

IL-1\u03b2 and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development.
<\/a>Stouch AN, McCoy AM, Greer RM, Lakhdari O, Yull FE, Blackwell TS, Hoffman HM, Prince LS.
J Immunol. 2016 Apr 15;196(8):3411-20. doi: 10.4049\/jimmunol.1500906. Epub 2016 Mar 7.<\/p>\n

Inflammation-Related IL1\u03b2\/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma.
<\/a>Kadariya Y, Menges CW, Talarchek J, Cai KQ, Klein-Szanto AJ, Pietrofesa RA, Christofidou-Solomidou M, Cheung M, Mossman BT, Shukla A, Testa JR.
Cancer Prev Res (Phila). 2016 May;9(5):406-414. doi: 10.1158\/1940-6207.CAPR-15-0347. Epub 2016 Mar 2.<\/p>\n

Age-Dependent Susceptibility to Pulmonary Fibrosis Is Associated with\u00a0NLRP3\u00a0Inflammasome Activation.
<\/a>Stout-Delgado HW, Cho SJ, Chu SG, Mitzel DN, Villalba J, El-Chemaly S, Ryter SW, Choi AM, Rosas IO.
Am J Respir Cell Mol Biol. 2016 Aug;55(2):252-63. doi: 10.1165\/rcmb.2015-0222OC.<\/p>\n

Innate recognition of influenza virus and vaccine development.
<\/a>Ichinohe T.
Uirusu. 2015;65(1):127-34. doi: 10.2222\/jsv.65.127. Review. Japanese.<\/p>\n

Autophagy and Obesity-Related\u00a0Lung Disease.
<\/a>Pabon MA, Ma KC, Choi AM.
Am J Respir Cell Mol Biol. 2016 May;54(5):636-46. doi: 10.1165\/rcmb.2016-0045PS. Review.<\/p>\n

Melatonin alleviates acute\u00a0lung\u00a0injury through inhibiting the\u00a0NLRP3\u00a0inflammasome.
<\/a>Zhang Y, Li X, Grailer JJ, Wang N, Wang M, Yao J, Zhong R, Gao GF, Ward PA, Tan DX, Li X.
J Pineal Res. 2016 May;60(4):405-14. doi: 10.1111\/jpi.12322. Epub 2016 Mar 9.<\/p>\n

Role of Linear Ubiquitination in Health and\u00a0Disease.
<\/a>Brazee P, Dada LA, Sznajder JI.
Am J Respir Cell Mol Biol. 2016 Jun;54(6):761-8. doi: 10.1165\/rcmb.2016-0014TR. Review.<\/p>\n

Neutrophil extracellular traps are associated with inflammation in chronic airway\u00a0disease.
<\/a>Wright TK, Gibson PG, Simpson JL, McDonald VM, Wood LG, Baines KJ.
Respirology. 2016 Apr;21(3):467-75. doi: 10.1111\/resp.12730. Epub 2016 Jan 25.<\/p>\n

Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice.
<\/a>Mardare C, Kr\u00fcger K, Liebisch G, Seimetz M, Couturier A, Ringseis R, Wilhelm J, Weissmann N, Eder K, Mooren FC.
J Diabetes Res. 2016;2016:4536470. doi: 10.1155\/2016\/4536470. Epub 2015 Dec 14.<\/p>\n

Activation of\u00a0NLRP3\u00a0inflammasome enhances the proliferation and migration of A549\u00a0lung\u00a0cancer cells.
<\/a>Wang Y, Kong H, Zeng X, Liu W, Wang Z, Yan X, Wang H, Xie W.
Oncol Rep. 2016 Apr;35(4):2053-64. doi: 10.3892\/or.2016.4569. Epub 2016 Jan 18.<\/p>\n

Next generation sequencing revealed DNA ligase IV deficiency in a “developmentally normal” patient with massive brain Epstein-Barr virus-positive diffuse large B-cell lymphoma.
<\/a>Sharapova SO, Chang EY, Guryanova IE, Proleskovskaya IV, Fedorova AS, Rutskaya EA, Aleinikova OV.
Clin Immunol. 2016 Feb;163:108-10. doi: 10.1016\/j.clim.2016.01.002. Epub 2016 Jan 13<\/p>\n

Deletion of P2X7 attenuates hyperoxia-induced acute\u00a0lung\u00a0injury via inflammasome suppression.
<\/a>Galam L, Rajan A, Failla A, Soundararajan R, Lockey RF, Kolliputi N.
Am J Physiol\u00a0Lung\u00a0Cell Mol Physiol. 2016 Mar 15;310(6):L572-81. doi: 10.1152\/ajplung.00417.2015. Epub 2016 Jan 8.<\/p>\n

NLRP3\u00a0inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid\u00a0lung.
<\/a>Lasithiotaki I, Giannarakis I, Tsitoura E, Samara KD, Margaritopoulos GA, Choulaki C, Vasarmidi E, Tzanakis N, Voloudaki A, Sidiropoulos P, Siafakas NM, Antoniou KM.
Eur Respir J. 2016 Mar;47(3):910-8. doi: 10.1183\/13993003.00564-2015. Epub 2016 Jan 7.<\/p>\n

Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of\u00a0Lung\u00a0Inflammation and Emphysema in Mice.
<\/a>Li F, Zhang P, Zhang M, Liang L, Sun X, Li M, Tang Y, Bao A, Gong J, Zhang J, Adcock I, Chung KF, Zhou X.
Am J Respir Cell Mol Biol. 2016 Jul;55(1):72-81. doi: 10.1165\/rcmb.2015-0014OC.<\/p>\n

NLRP3\u00a0inflammasome is essential for the development of chronic obstructive pulmonary\u00a0disease.
<\/a>Yang W, Ni H, Wang H, Gu H.
Int J Clin Exp Pathol. 2015 Oct 1;8(10):13209-16. eCollection 2015.<\/p>\n

Inflammasome Modulation by Chemotherapeutics in Malignant Mesothelioma.
<\/a>Westbom C, Thompson JK, Leggett A, MacPherson M, Beuschel S, Pass H, Vacek P, Shukla A.
PLoS One. 2015 Dec 21;10(12):e0145404. doi: 10.1371\/journal.pone.0145404. eCollection 2015.<\/p>\n

Genipin inhibits\u00a0NLRP3\u00a0and NLRC4 inflammasome activation via autophagy suppression.
<\/a>Yu SX, Du CT, Chen W, Lei QQ, Li N, Qi S, Zhang XJ, Hu GQ, Deng XM, Han WY, Yang YJ.
Sci Rep. 2015 Dec 11;5:17935. doi: 10.1038\/srep17935.<\/p>\n

The\u00a0NLRP3\u00a0inflammasome is critically involved in the development of bronchopulmonary dysplasia.
<\/a>Liao J, Kapadia VS, Brown LS, Cheong N, Longoria C, Mija D, Ramgopal M, Mirpuri J, McCurnin DC, Savani RC.
Nat Commun. 2015 Nov 27;6:8977. doi: 10.1038\/ncomms9977.<\/p>\n

Sepsis and ARDS: The Dark Side of Histones.
<\/a>Xu Z, Huang Y, Mao P, Zhang J, Li Y.
Mediators Inflamm. 2015;2015:205054. doi: 10.1155\/2015\/205054. Epub 2015 Nov 1. Review<\/p>\n

Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of\u00a0NLRP3\u00a0inflammasome and enhancing Nrf2 activation.
<\/a>Ka SM, Lin JC, Lin TJ, Liu FC, Chao LK, Ho CL, Yeh LT, Sytwu HK, Hua KF, Chen A.
Arthritis Res Ther. 2015 Nov 19;17:331. doi: 10.1186\/s13075-015-0844-6.<\/p>\n

ROS-Mediated\u00a0NLRP3\u00a0Inflammasome Activity Is Essential for Burn-Induced Acute\u00a0Lung\u00a0Injury.
<\/a>Han S, Cai W, Yang X, Jia Y, Zheng Z, Wang H, Li J, Li Y, Gao J, Fan L, Hu D.
Mediators Inflamm. 2015;2015:720457. doi: 10.1155\/2015\/720457. Epub 2015 Oct 20.<\/p>\n

Blockade of Interplay between IL-17A and Endoplasmic Reticulum Stress Attenuates LPS-Induced\u00a0Lung\u00a0Injury.
<\/a>Kim SR, Kim HJ, Kim DI, Lee KB, Park HJ, Jeong JS, Cho SH, Lee YC.
Theranostics. 2015 Oct 7;5(12):1343-62. doi: 10.7150\/thno.11685. eCollection 2015.<\/p>\n

Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo.
<\/a>Huang TT, Lai HC, Ko YF, Ojcius DM, Lan YW, Martel J, Young JD, Chong KY.
Sci Rep. 2015 Oct 26;5:15282. doi: 10.1038\/srep15282.<\/p>\n

Effects of the Interactions between Dust Exposure and Genetic Polymorphisms in Nalp3, Caspase-1, and IL-1\u03b2 on the Risk of Silicosis: A Case-Control Study.
<\/a>Weng S, Wang L, Rong Y, Liu Y, Wang X, Guan H, Chen W.
PLoS One. 2015 Oct 23;10(10):e0140952. doi: 10.1371\/journal.pone.0140952. eCollection 2015.<\/p>\n

Inflammasomes in COPD and neutrophilic asthma.
<\/a>Kim RY, Pinkerton JW, Gibson PG, Cooper MA, Horvat JC, Hansbro PM.
Thorax. 2015 Dec;70(12):1199-201. doi: 10.1136\/thoraxjnl-2014-206736. Epub 2015 Oct 22. No abstract available.<\/p>\n

Carbon monoxide decreases interleukin-1\u03b2 levels in the\u00a0lung\u00a0through the induction of pyrin.
<\/a>Kim SK, Joe Y, Chen Y, Ryu J, Lee JH, Cho GJ, Ryter SW, Chung HT.
Cell Mol Immunol. 2017 Apr;14(4):349-359. doi: 10.1038\/cmi.2015.79. Epub 2015 Oct 19.<\/p>\n

Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in\u00a0Lung Disease.
<\/a>Lee S, Suh GY, Ryter SW, Choi AM.
Am J Respir Cell Mol Biol. 2016 Feb;54(2):151-60. doi: 10.1165\/rcmb.2015-0231TR. Review.<\/p>\n

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human\u00a0Lung\u00a0Tissue.
<\/a>Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B.
PLoS One. 2015 Aug 28;10(8):e0137108. doi: 10.1371\/journal.pone.0137108. eCollection 2015.<\/p>\n

Tissue-specific expression pattern and histological distribution of\u00a0NLRP3\u00a0in Chinese yellow chicken.
<\/a>Ye J, Yu M, Zhang K, Liu J, Wang Q, Tao P, Jia K, Liao M, Ning Z.
Vet Res Commun. 2015 Sep;39(3):171-7. doi: 10.1007\/s11259-015-9641-6. Epub 2015 Aug 6.<\/p>\n

Helicobacter urease-induced activation of the TLR2\/NLRP3\/IL-18 axis protects against asthma.
<\/a>Koch KN, Hartung ML, Urban S, Kyburz A, Bahlmann AS, Lind J, Backert S, Taube C, M\u00fcller A.
J Clin Invest. 2015 Aug 3;125(8):3297-302. doi: 10.1172\/JCI79337. Epub 2015 Jul 27.<\/p>\n

Reduction of Acute Inflammatory Effects of Fumed Silica Nanoparticles in the\u00a0Lung\u00a0by Adjusting Silanol Display through Calcination and Metal Doping.
<\/a>Sun B, Pokhrel S, Dunphy DR, Zhang H, Ji Z, Wang X, Wang M, Liao YP, Chang CH, Dong J, Li R, M\u00e4dler L, Brinker CJ, Nel AE, Xia T.
ACS Nano. 2015 Sep 22;9(9):9357-72. doi: 10.1021\/acsnano.5b03443. Epub 2015 Jul 29.<\/p>\n

Genipin suppresses\u00a0NLRP3\u00a0inflammasome activation through uncoupling protein-2.
<\/a>Rajanbabu V, Galam L, Fukumoto J, Enciso J, Tadikonda P, Lane TN, Bandyopadhyay S, Parthasarathy PT, Cho Y, Cho SH, Lee YC, Lockey RF, Kolliputi N.
Cell Immunol. 2015 Sep;297(1):40-5. doi: 10.1016\/j.cellimm.2015.06.002. Epub 2015 Jun 16.<\/p>\n

The receptor\u00a0NLRP3\u00a0is a transcriptional regulator of TH2 differentiation.
<\/a>Bruchard M, Reb\u00e9 C, Derang\u00e8re V, Togb\u00e9 D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, Chevriaux A, Limagne E, Apetoh L, V\u00e9gran F, Ghiringhelli F.
Nat Immunol. 2015 Aug;16(8):859-70. doi: 10.1038\/ni.3202. Epub 2015 Jun 22. Erratum in:\u00a0Nat Immunol. 2015 Dec;16(12):1292<\/a>.<\/p>\n

Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.
<\/a>Cero FT, Hillestad V, Sjaastad I, Yndestad A, Aukrust P, Ranheim T, Lunde IG, Olsen MB, Lien E, Zhang L, Haugstad SB, L\u00f8berg EM, Christensen G, Larsen KO, Skj\u00f8nsberg OH.
Am J Physiol\u00a0Lung\u00a0Cell Mol Physiol. 2015 Aug 15;309(4):L378-87. doi: 10.1152\/ajplung.00342.2014. Epub 2015 Jun 12.<\/p>\n

Silica-induced inflammasome activation in macrophages: role of ATP and P2X7 receptor.
<\/a>Luna-Gomes T, Santana PT, Coutinho-Silva R.
Immunobiology. 2015 Sep;220(9):1101-6. doi: 10.1016\/j.imbio.2015.05.004. Epub 2015 May 18. Review.<\/p>\n

The role of the\u00a0NLRP3\u00a0inflammasome in pulmonary\u00a0diseases.
<\/a>Hosseinian N, Cho Y, Lockey RF, Kolliputi N.
Ther Adv Respir Dis. 2015 Aug;9(4):188-97. doi: 10.1177\/1753465815586335. Epub 2015 May 26. Review.<\/p>\n

Brief Report: Cryopyrin-Associated Periodic Syndrome Caused by a Myeloid-Restricted Somatic\u00a0NLRP3\u00a0Mutation.
<\/a>Zhou Q, Aksentijevich I, Wood GM, Walts AD, Hoffmann P, Remmers EF, Kastner DL, Ombrello AK.
Arthritis Rheumatol. 2015 Sep;67(9):2482-6. doi: 10.1002\/art.39190.<\/p>\n

Anti-inflammatory effect of Impatiens textori Miq. extract via inhibition of\u00a0NLRP3\u00a0inflammasome activation in in vitro and in vivo experimental models.
<\/a>Sun X, Shim DW, Han JW, Shin WY, Sim EJ, Kim MK, Heo KH, Kim YK, Koppula S, Kim TJ, Kang TB, Lee KH.
J Ethnopharmacol. 2015 Jul 21;170:81-7. doi: 10.1016\/j.jep.2015.05.001. Epub 2015 May 11.<\/p>\n

Blockage of P2X7 attenuates acute\u00a0lung\u00a0injury in mice by inhibiting\u00a0NLRP3\u00a0inflammasome.
<\/a>Wang S, Zhao J, Wang H, Liang Y, Yang N, Huang Y.
Int Immunopharmacol. 2015 Jul;27(1):38-45. doi: 10.1016\/j.intimp.2015.04.035. Epub 2015 Apr 29<\/p>\n

Phosphatidylinositol 3-kinases pathway mediates\u00a0lung\u00a0caspase-1 activation and high mobility group box 1 production in a toluene-diisocyanate induced murine asthma model.
<\/a>Liang J, Zhao H, Yao L, Tang H, Dong H, Wu Y, Liu L, Zou F, Cai S.
Toxicol Lett. 2015 Jul 2;236(1):25-33. doi: 10.1016\/j.toxlet.2015.04.011. Epub 2015 Apr 27.<\/p>\n

Differential expression of inflammasomes in\u00a0lung\u00a0cancer cell lines and tissues.
<\/a>Kong H, Wang Y, Zeng X, Wang Z, Wang H, Xie W.
Tumour Biol. 2015 Sep;36(10):7501-13. doi: 10.1007\/s13277-015-3473-4. Epub 2015 Apr 25.<\/p>\n

NLRP3, a Double-edged Sword in\u00a0Lung\u00a0Injury\u00a0Diseases.
<\/a>Wu JX, Shi KH.
Inflammation. 2015 Oct;38(5):1855-6. doi: 10.1007\/s10753-015-0163-8.<\/p>\n

Toxin-induced necroptosis is a major mechanism of Staphylococcus aureus\u00a0lung\u00a0damage.
<\/a>Kitur K, Parker D, Nieto P, Ahn DS, Cohen TS, Chung S, Wachtel S, Bueno S, Prince A.
PLoS Pathog. 2015 Apr 16;11(4):e1004820. doi: 10.1371\/journal.ppat.1004820. eCollection 2015 Ap<\/p>\n

Sintered indium-tin oxide particles induce pro-inflammatory responses in vitro, in part through inflammasome activation.
<\/a>Badding MA, Schwegler-Berry D, Park JH, Fix NR, Cummings KJ, Leonard SS.
PLoS One. 2015 Apr 13;10(4):e0124368. doi: 10.1371\/journal.pone.0124368. eCollection 2015.<\/p>\n

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.
<\/a>Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, Maruya M, Ian McKenzie C, Hijikata A, Wong C, Binge L, Thorburn AN, Chevalier N, Ang C, Marino E, Robert R, Offermanns S, Teixeira MM, Moore RJ, Flavell RA, Fagarasan S, Mackay CR.
Nat Commun. 2015 Apr 1;6:6734. doi: 10.1038\/ncomms7734.<\/p>\n

IL-18 triggered by the\u00a0Nlrp3\u00a0inflammasome induces host innate resistance in a pulmonary model of fungal infection.
<\/a>Ketelut-Carneiro N, Silva GK, Rocha FA, Milanezi CM, Cavalcanti-Neto FF, Zamboni DS, Silva JS.
J Immunol. 2015 May 1;194(9):4507-17. doi: 10.4049\/jimmunol.1402321. Epub 2015 Mar 30.<\/p>\n

The inflammasome accelerates radiation-induced\u00a0lung\u00a0inflammation and fibrosis in mice.
<\/a>Sohn SH, Lee JM, Park S, Yoo H, Kang JW, Shin D, Jung KH, Lee YS, Cho J, Bae H.
Environ Toxicol Pharmacol. 2015 Mar;39(2):917-26. doi: 10.1016\/j.etap.2015.02.019. Epub 2015 Mar 7.<\/p>\n

Carbon monoxide negatively regulates\u00a0NLRP3\u00a0inflammasome activation in macrophages.
<\/a>Jung SS, Moon JS, Xu JF, Ifedigbo E, Ryter SW, Choi AM, Nakahira K.
Am J Physiol\u00a0Lung\u00a0Cell Mol Physiol. 2015 May 15;308(10):L1058-67. doi: 10.1152\/ajplung.00400.2014. Epub 2015 Mar 13.<\/p>\n

Vimentin regulates activation of the\u00a0NLRP3\u00a0inflammasome.
<\/a>dos Santos G, Rogel MR, Baker MA, Troken JR, Urich D, Morales-Nebreda L, Sennello JA, Kutuzov MA, Sitikov A, Davis JM, Lam AP, Cheresh P, Kamp D, Shumaker DK, Budinger GR, Ridge KM.
Nat Commun. 2015 Mar 12;6:6574. doi: 10.1038\/ncomms7574.<\/p>\n

Endogenous metabolites and inflammasome activity in early childhood and links to respiratory\u00a0diseases.
<\/a>Herberth G, Offenberg K, Rolle-Kampczyk U, Bauer M, Otto W, R\u00f6der S, Gr\u00fctzmann K, Sack U, Simon JC, Borte M, von Bergen M, Lehmann I; LINA Study Group.
J Allergy Clin Immunol. 2015 Aug;136(2):495-7. doi: 10.1016\/j.jaci.2015.01.022. Epub 2015 Mar 7. No abstract available.<\/p>\n

Temporal regulation of cytokine mRNA expression by tristetraprolin: dynamic control by p38 MAPK and MKP-1.
<\/a>Prabhala P, Bunge K, Rahman MM, Ge Q, Clark AR, Ammit AJ.
Am J Physiol\u00a0Lung\u00a0Cell Mol Physiol. 2015 May 1;308(9):L973-80. doi: 10.1152\/ajplung.00219.2014. Epub 2015 Feb 27.<\/p>\n

Caspase-1 activation by\u00a0NLRP3\u00a0inflammasome dampens IL-33-dependent house dust mite-induced allergic\u00a0lung\u00a0inflammation.
<\/a>Madouri F, Guillou N, Fauconnier L, Marchiol T, Rouxel N, Chenuet P, Ledru A, Apetoh L, Ghiringhelli F, Chamaillard M, Zheng SG, Trovero F, Quesniaux VF, Ryffel B, Togbe D.
J Mol Cell Biol. 2015 Aug;7(4):351-65. doi: 10.1093\/jmcb\/mjv012. Epub 2015 Feb 24.<\/p>\n

A novel synthetic derivative of melatonin, 5-hydroxy-2′-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation.
<\/a>Shim DW, Shin HJ, Han JW, Ji YE, Jang CH, Koppula S, Kang TB, Lee KH.
Toxicol Appl Pharmacol. 2015 Apr 15;284(2):227-35. doi: 10.1016\/j.taap.2015.02.006. Epub 2015 Feb 14.<\/p>\n

The\u00a0NLRP3\u00a0inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
<\/a>Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, Panek C, Le Bert M, Lagente V, Rassendren F, Riteau N, Couillin I.
Cell Death Dis. 2015 Feb 5;6:e1629. doi: 10.1038\/cddis.2014.576.<\/p>\n

Mitochondrial Ca2+-dependent\u00a0NLRP3\u00a0activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis.
<\/a>Rimessi A, Bezzerri V, Patergnani S, Marchi S, Cabrini G, Pinton P.
Nat Commun. 2015 Feb 4;6:6201. doi: 10.1038\/ncomms7201.<\/p>\n

Use of a pro-fibrogenic mechanism-based predictive toxicological approach for tiered testing and decision analysis of carbonaceous nanomaterials.
<\/a>Wang X, Duch MC, Mansukhani N, Ji Z, Liao YP, Wang M, Zhang H, Sun B, Chang CH, Li R, Lin S, Meng H, Xia T, Hersam MC, Nel AE.
ACS Nano. 2015 Mar 24;9(3):3032-43. doi: 10.1021\/nn507243w. Epub 2015 Feb 18.<\/p>\n

NADPH Oxidase-Dependent\u00a0NLRP3\u00a0Inflammasome Activation and its Important Role in\u00a0LungFibrosis by Multiwalled Carbon Nanotubes.
<\/a>Sun B, Wang X, Ji Z, Wang M, Liao YP, Chang CH, Li R, Zhang H, Nel AE, Xia T.
Small. 2015 May 6;11(17):2087-97. doi: 10.1002\/smll.201402859. Epub 2015 Jan 12.<\/p>\n

Peroxyauraptenol Inhibits Inflammation and\u00a0NLRP3\u00a0Inflammasome Activation by Inhibiting Reactive Oxygen Species Generation and Preserving Mitochondrial Integrity.
<\/a>Chao LK, Lin CH, Chiu HW, Wong WT, Chiu HW, Tasi YL, Kuo YH, Chiu YC, Liu ML, Ho CL, Hua KF.
J Agric Food Chem. 2015 Feb 4;63(4):1210-1219. doi: 10.1021\/jf5054436. Epub 2015 Jan 22.<\/p>\n

NLRP3\u00a0protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1\u03b2.
<\/a>Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M.
J Biol Chem. 2015 Feb 20;290(8):5065-77. doi: 10.1074\/jbc.M114.603217. Epub 2014 Dec 29.<\/p>\n

Expression pattern of\u00a0NLRP3\u00a0and its related cytokines in the\u00a0lung\u00a0and brain of avian influenza virus H9N2 infected BALB\/c mice.
<\/a>Yu M, Zhang K, Qi W, Huang Z, Ye J, Ma Y, Liao M, Ning Z.
Virol J. 2014 Dec 30;11:229. doi: 10.1186\/s12985-014-0229-5<\/p>\n

Ellagic acid prevents monocrotaline-induced pulmonary artery hypertension via inhibiting\u00a0NLRP3inflammasome activation in rats.
<\/a>Tang B, Chen GX, Liang MY, Yao JP, Wu ZK.
Int J Cardiol. 2015 Feb 1;180:134-41. doi: 10.1016\/j.ijcard.2014.11.161. Epub 2014 Nov 25.<\/p>\n

Silica-induced\u00a0NLRP3\u00a0inflammasome activation in vitro and in rat lungs.
<\/a>Peeters PM, Eurlings IM, Perkins TN, Wouters EF, Schins RP, Borm PJ, Drommer W, Reynaert NL, Albrecht C.
Part Fibre Toxicol. 2014 Nov 19;11:58. doi: 10.1186\/s12989-014-0058-0.<\/p>\n

Iron, inflammation, and early death in adults with sickle cell\u00a0disease.
<\/a>van Beers EJ, Yang Y, Raghavachari N, Tian X, Allen DT, Nichols JS, Mendelsohn L, Nekhai S, Gordeuk VR, Taylor JG 6th, Kato GJ.
Circ Res. 2015 Jan 16;116(2):298-306. doi: 10.1161\/CIRCRESAHA.116.304577. Epub 2014 Nov 6.<\/p>\n

IL-37 inhibits inflammasome activation and\u00a0disease\u00a0severity in murine aspergillosis.
<\/a>Moretti S, Bozza S, Oikonomou V, Renga G, Casagrande A, Iannitti RG, Puccetti M, Garlanda C, Kim S, Li S, van de Veerdonk FL, Dinarello CA, Romani L.
PLoS Pathog. 2014 Nov 6;10(11):e1004462. doi: 10.1371\/journal.ppat.1004462. eCollection 2014 Nov.<\/p>\n

NLRP3\u00a0inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation.
<\/a>Kim SR, Kim DI, Kim SH, Lee H, Lee KS, Cho SH, Lee YC.
Cell Death Dis. 2014 Oct 30;5:e1498. doi: 10.1038\/cddis.2014.460.<\/p>\n

NLRP3\u00a0inflammasome activation is essential for paraquat-induced acute\u00a0lung\u00a0injury.
<\/a>Liu Z, Zhao H, Liu W, Li T, Wang Y, Zhao M.
Inflammation. 2015 Feb;38(1):433-44. doi: 10.1007\/s10753-014-0048-2.<\/p>\n

Molecular activation of the\u00a0NLRP3\u00a0Inflammasome in fibrosis: common threads linking divergent fibrogenic\u00a0diseases.
<\/a>Artlett CM, Thacker JD.
Antioxid Redox Signal. 2015 May 1;22(13):1162-75. doi: 10.1089\/ars.2014.6148. Epub 2014 Dec 9. Review.<\/p>\n

Immune complexes inhibit IL-1 secretion and inflammasome activation.
<\/a>Janczy JR, Ciraci C, Haasken S, Iwakura Y, Olivier AK, Cassel SL, Sutterwala FS.
J Immunol. 2014 Nov 15;193(10):5190-8. doi: 10.4049\/jimmunol.1400628. Epub 2014 Oct 15.<\/p>\n

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.
<\/a>Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O’Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R.
Nat Genet. 2014 Oct;46(10):1140-6. doi: 10.1038\/ng.3089. Epub 2014 Sep 14<\/p>\n

NLRP3\u00a0inflammasome sequential changes in Staphylococcus aureus-induced mouse model of acute rhinosinusitis.
<\/a>Wang YJ, Gong GQ, Chen S, Xiong LY, Zhou XX, Huang X, Kong WJ.
Int J Mol Sci. 2014 Sep 9;15(9):15806-20. doi: 10.3390\/ijms150915806.<\/p>\n

Acapsular Cryptococcus neoformans activates the\u00a0NLRP3\u00a0inflammasome.
<\/a>Guo C, Chen M, Fa Z, Lu A, Fang W, Sun B, Chen C, Liao W, Meng G.
Microbes Infect. 2014 Oct;16(10):845-54. doi: 10.1016\/j.micinf.2014.08.013. Epub 2014 Sep 2.<\/p>\n

Involvement of\u00a0NLRP3\u00a0inflammasome in rituximab-induced interstitial\u00a0lung disease: a case report.
<\/a>Kong H, Wang Y, Zeng X, Zhu Q, Xie W, Dai S.
J Clin Pharm Ther. 2014 Dec;39(6):691-4. doi: 10.1111\/jcpt.12198. Epub 2014 Aug 16.<\/p>\n

The nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome\/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 \u03bcm.
<\/a>Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D, Hansbro PM, Carlsten C, VanEeden S, Sin DD, McNagny KM, Knight DA.
Am J Respir Cell Mol Biol. 2015 Jan;52(1):96-105. doi: 10.1165\/rcmb.2014-0158OC.<\/p>\n

Functional relevance of\u00a0NLRP3\u00a0inflammasome-mediated interleukin (IL)-1\u03b2 during acute allergic airway inflammation.
<\/a>Ritter M, Straubinger K, Schmidt S, Busch DH, Hagner S, Garn H, Prazeres da Costa C, Layland LE.
Clin Exp Immunol. 2014 Nov;178(2):212-23. doi: 10.1111\/cei.12400.<\/p>\n

Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in\u00a0lung\u00a0fibroblasts.
<\/a>Hussain S, Sangtian S, Anderson SM, Snyder RJ, Marshburn JD, Rice AB, Bonner JC, Garantziotis S.
Part Fibre Toxicol. 2014 Jun 10;11:28. doi: 10.1186\/1743-8977-11-28.<\/p>\n

The effects of morin on lipopolysaccharide-induced acute\u00a0lung\u00a0injury by suppressing the\u00a0lung\u00a0NLRP3inflammasome.
<\/a>Tianzhu Z, Shihai Y, Juan D.
Inflammation. 2014 Dec;37(6):1976-83. doi: 10.1007\/s10753-014-9930-1.<\/p>\n

Autophagy in pulmonary macrophages mediates\u00a0lung\u00a0inflammatory injury via\u00a0NLRP3\u00a0inflammasome activation during mechanical ventilation.
<\/a>Zhang Y, Liu G, Dull RO, Schwartz DE, Hu G.
Am J Physiol\u00a0Lung\u00a0Cell Mol Physiol. 2014 Jul 15;307(2):L173-85. doi: 10.1152\/ajplung.00083.2014. Epub 2014 May 16.<\/p>\n

Critical role for the\u00a0NLRP3\u00a0inflammasome during acute\u00a0lung\u00a0injury.
<\/a>Grailer JJ, Canning BA, Kalbitz M, Haggadone MD, Dhond RM, Andjelkovic AV, Zetoune FS, Ward PA.
J Immunol. 2014 Jun 15;192(12):5974-83. doi: 10.4049\/jimmunol.1400368. Epub 2014 May 2.<\/p>\n

Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial\u00a0lunginfection.
<\/a>Leissinger M, Kulkarni R, Zemans RL, Downey GP, Jeyaseelan S.
Am J Respir Crit Care Med. 2014 Jun 15;189(12):1461-8. doi: 10.1164\/rccm.201311-2103PP. Review.<\/p>\n

Extracellular histones in tissue injury and inflammation.
<\/a>Allam R, Kumar SV, Darisipudi MN, Anders HJ.
J Mol Med (Berl). 2014 May;92(5):465-72. doi: 10.1007\/s00109-014-1148-z. Epub 2014 Apr 6. Review.<\/p>\n

Critical role of aquaporins in interleukin 1\u03b2 (IL-1\u03b2)-induced inflammation.
<\/a>Rabolli V, Wallemme L, Lo Re S, Uwambayinema F, Palmai-Pallag M, Thomassen L, Tyteca D, Octave JN, Marbaix E, Lison D, Devuyst O, Huaux F.
J Biol Chem. 2014 May 16;289(20):13937-47. doi: 10.1074\/jbc.M113.534594. Epub 2014 Apr 3.<\/p>\n

Luteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of\u00a0NLRP3\u00a0inflammasome.
<\/a>Fan SH, Wang YY, Lu J, Zheng YL, Wu DM, Li MQ, Hu B, Zhang ZF, Cheng W, Shan Q.
PLoS One. 2014 Feb 26;9(2):e89961. doi: 10.1371\/journal.pone.0089961. eCollection 2014.<\/p>\n

Hemin inhibits\u00a0NLRP3\u00a0inflammasome activation in sepsis-induced acute\u00a0lung\u00a0injury, involving heme oxygenase-1.
<\/a>Luo YP, Jiang L, Kang K, Fei DS, Meng XL, Nan CC, Pan SH, Zhao MR, Zhao MY.
Int Immunopharmacol. 2014 May;20(1):24-32. doi: 10.1016\/j.intimp.2014.02.017. Epub 2014 Feb 26.<\/p>\n

The role of the inflammasome in fibrotic respiratory\u00a0diseases.
<\/a>Rastrick J, Birrell M.
Minerva Med. 2014 Feb;105(1):9-23. Review.<\/p>\n

Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways.
<\/a>Fanton d’Andon M, Quellard N, Fernandez B, Ratet G, Lacroix-Lamand\u00e9 S, Vandewalle A, Boneca IG, Goujon JM, Werts C.
PLoS Negl Trop Dis. 2014 Jan 30;8(1):e2664. doi: 10.1371\/journal.pntd.0002664. eCollection 2014. Erratum in: PLoS Negl Trop Dis. 2014 Apr;8(4):e2802.<\/p>\n

Curcumin: a double hit on malignant mesothelioma.
<\/a>Miller JM, Thompson JK, MacPherson MB, Beuschel SL, Westbom CM, Sayan M, Shukla A.
Cancer Prev Res (Phila). 2014 Mar;7(3):330-40. doi: 10.1158\/1940-6207.CAPR-13-0259. Epub 2014 Jan 15.<\/p>\n

Innate immunity but not\u00a0NLRP3\u00a0inflammasome activation correlates with severity of stable COPD.
<\/a>Di Stefano A, Caramori G, Barczyk A, Vicari C, Brun P, Zanini A, Cappello F, Garofano E, Padovani A, Contoli M, Casolari P, Durham AL, Chung KF, Barnes PJ, Papi A, Adcock I, Balbi B.
Thorax. 2014 Jun;69(6):516-24. doi: 10.1136\/thoraxjnl-2012-203062. Epub 2014 Jan 15.<\/p>\n

An innate link between obesity and asthma.
<\/a>Celed\u00f3n JC, Kolls JK.
Nat Med. 2014 Jan;20(1):19-20. doi: 10.1038\/nm.3433. No abstract available.<\/p>\n

Targeting reactive oxygen species by edaravone inhalation in a rat hyperoxic\u00a0lung\u00a0injury model: role of inflammasome.
<\/a>Wang C, Ye Z, Zheng J, Liu K, Sun X, Tao H, Liu W.
Undersea Hyperb Med. 2013 Nov-Dec;40(6):505-11.<\/p>\n

Interleukin-17-producing innate lymphoid cells and the\u00a0NLRP3\u00a0inflammasome facilitate obesity-associated airway hyperreactivity.
<\/a>Kim HY, Lee HJ, Chang YJ, Pichavant M, Shore SA, Fitzgerald KA, Iwakura Y, Israel E, Bolger K, Faul J, DeKruyff RH, Umetsu DT.
Nat Med. 2014 Jan;20(1):54-61. doi: 10.1038\/nm.3423. Epub 2013 Dec 15.<\/p>\n

Tobacco smoke-induced\u00a0lung\u00a0fibrosis and emphysema.
<\/a>Morse D, Rosas IO.
Annu Rev Physiol. 2014;76:493-513. doi: 10.1146\/annurev-physiol-021113-170411. Epub 2013 Nov 18. Review.<\/p>\n

Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell\u00a0lung\u00a0cancer.
<\/a>Kim HS, Mendiratta S, Kim J, Pecot CV, Larsen JE, Zubovych I, Seo BY, Kim J, Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs JE, Wei S, Peyton M, Williams N, Gazdar AF, Posner BA, Brekken RA, Sood AK, Deberardinis RJ, Roth MG, Minna JD, White MA.
Cell. 2013 Oct 24;155(3):552-66. doi: 10.1016\/j.cell.2013.09.041. Epub 2013 Oct 24<\/p>\n

New insights into mechanisms controlling the\u00a0NLRP3\u00a0inflammasome and its role in\u00a0lung disease.
<\/a>De Nardo D, De Nardo CM, Latz E.
Am J Pathol. 2014 Jan;184(1):42-54. doi: 10.1016\/j.ajpath.2013.09.007. Epub 2013 Oct 30. Review.<\/p>\n

NLRP3\u00a0and ASC differentially affect the\u00a0lung\u00a0<\/a><\/span>transcriptome during pneumococcal pneumonia.
<\/a>van Lieshout MH, Scicluna BP, Florquin S, van der Poll T.m
J Respir Cell Mol Biol. 2014 Apr;50(4):699-712. doi: 10.1165\/rcmb.2013-0015OC.<\/p>\n

Genes involved in innate immunity associated with asbestos-related fibrotic changes.
<\/a>Kukkonen MK, Vehmas T, Piiril\u00e4 P, Hirvonen A.
Occup Environ Med. 2014 Jan;71(1):48-54. doi: 10.1136\/oemed-2013-101555. Epub 2013 Oct 4.<\/p>\n

Elevated expression of the\u00a0NLRP3\u00a0inflammasome in neutrophilic asthma.
<\/a>Simpson JL, Phipps S, Baines KJ, Oreo KM, Gunawardhana L, Gibson PG.
Eur Respir J. 2014 Apr;43(4):1067-76. doi: 10.1183\/09031936.00105013. Epub 2013 Oct 17.<\/p>\n

The\u00a0NLRP3\u00a0inflammasome: role in airway inflammation.
<\/a>Im H, Ammit AJ.
Clin Exp Allergy. 2014 Feb;44(2):160-72. doi: 10.1111\/cea.12206. Review.<\/p>\n

Polyenylpyrrole derivatives inhibit\u00a0NLRP3\u00a0inflammasome activation and inflammatory mediator expression by reducing reactive oxygen species production and mitogen-activated protein kinase activation.
<\/a>Hua KF, Chou JC, Lam Y, Tasi YL, Chen A, Ka SM, Fang Z, Liu ML, Yang FL, Yang YL, Chiu YC, Wu SH.
PLoS One. 2013 Oct 7;8(10):e76754. doi: 10.1371\/journal.pone.0076754. eCollection 2013.<\/p>\n

The\u00a0NLRP3\u00a0inflammasome is required for the development of hypoxemia in LPS\/mechanical ventilation acute\u00a0lung\u00a0injury.
<\/a>Jones HD, Crother TR, Gonzalez-Villalobos RA, Jupelli M, Chen S, Dagvadorj J, Arditi M, Shimada K.
Am J Respir Cell Mol Biol. 2014 Feb;50(2):270-80. doi: 10.1165\/rcmb.2013-0087OC.<\/p>\n

Inflammation and immune response in COPD: where do we stand?
<\/a>Rovina N, Koutsoukou A, Koulouris NG.
Mediators Inflamm. 2013;2013:413735. doi: 10.1155\/2013\/413735. Epub 2013 Jul 15. Review.<\/p>\n

Viral infection of the\u00a0lung: host response and sequelae.
<\/a>Yoo JK, Kim TS, Hufford MM, Braciale TJ.
J Allergy Clin Immunol. 2013 Dec;132(6):1263-76; quiz 1277. doi: 10.1016\/j.jaci.2013.06.006. Epub 2013 Aug 1. Review.<\/p>\n

Nontypeable Haemophilus Influenzae Infection Upregulates the\u00a0NLRP3\u00a0Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1\u03b2 – A Possible Pathway of Exacerbations in COPD.
<\/a>Rotta Detto Loria J, Rohmann K, Droemann D, Kujath P, Rupp J, Goldmann T, Dalhoff K.
PLoS One. 2013 Jun 26;8(6):e66818. doi: 10.1371\/journal.pone.0066818. Print 2013.<\/p>\n

Rhinovirus-induced calcium flux triggers\u00a0NLRP3\u00a0and NLRC5 activation in bronchial cells.
<\/a>Triantafilou K, Kar S, van Kuppeveld FJ, Triantafilou M.
Am J Respir Cell Mol Biol. 2013 Dec;49(6):923-34. doi: 10.1165\/rcmb.2013-0032OC.<\/p>\n

Transfusion-Related Acute\u00a0Lung\u00a0Injury: The Work of DAMPs.
<\/a>Land WG.
Transfus Med Hemother. 2013 Feb;40(1):3-13. doi: 10.1159\/000345688. Epub 2013 Jan 3<\/p>\n

NLRP3\u00a0deletion protects from hyperoxia-induced acute\u00a0lung\u00a0injury.
<\/a>Fukumoto J, Fukumoto I, Parthasarathy PT, Cox R, Huynh B, Ramanathan GK, Venugopal RB, Allen-Gipson DS, Lockey RF, Kolliputi N.
Am J Physiol Cell Physiol. 2013 Jul 15;305(2):C182-9. doi: 10.1152\/ajpcell.00086.2013. Epub 2013 May 1.<\/p>\n

Early apoptosis of macrophages modulated by injection of Yersinia pestis YopK promotes progression of primary pneumonic plague.
<\/a>Peters KN, Dhariwala MO, Hughes Hanks JM, Brown CR, Anderson DM.
PLoS Pathog. 2013;9(4):e1003324. doi: 10.1371\/journal.ppat.1003324. Epub 2013 Apr 25.<\/p>\n

The nucleotide-binding domain and leucine-rich repeat protein-3 inflammasome is not activated in airway smooth muscle upon toll-like receptor-2 ligation.
<\/a>Hirota JA, Im H, Rahman MM, Rumzhum NN, Manetsch M, Pascoe CD, Bunge K, Alkhouri H, Oliver BG, Ammit AJ.
Am J Respir Cell Mol Biol. 2013 Oct;49(4):517-24. doi: 10.1165\/rcmb.2013-0047OC.<\/p>\n

Type I IFN triggers RIG-I\/TLR3\/NLRP3-dependent inflammasome activation in influenza A virus infected cells.
<\/a>Pothlichet J, Meunier I, Davis BK, Ting JP, Skamene E, von Messling V, Vidal SM.
PLoS Pathog. 2013;9(4):e1003256. doi: 10.1371\/journal.ppat.1003256. Epub 2013 Apr 11.<\/p>\n

Hemorrhagic shock augments\u00a0Nlrp3\u00a0inflammasome activation in the\u00a0lung\u00a0through impaired pyrin induction.
<\/a>Xu P, Wen Z, Shi X, Li Y, Fan L, Xiang M, Li A, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J.
J Immunol. 2013 May 15;190(10):5247-55. doi: 10.4049\/jimmunol.1203182. Epub 2013 Apr 12.<\/p>\n

NLRP3\u00a0inflammasomes show high expression in aorta of patients with atherosclerosis.
<\/a>Zheng F, Xing S, Gong Z, Xing Q.
Heart\u00a0Lung\u00a0Circ. 2013 Sep;22(9):746-50. doi: 10.1016\/j.hlc.2013.01.012. Epub 2013 Feb 23.<\/p>\n

Activation of\u00a0NLRP3\u00a0inflammasome in alveolar macrophages contributes to mechanical stretch-induced\u00a0lung\u00a0inflammation and injury.
<\/a>Wu J, Yan Z, Schwartz DE, Yu J, Malik AB, Hu G.
J Immunol. 2013 Apr 1;190(7):3590-9. doi: 10.4049\/jimmunol.1200860. Epub 2013 Feb 22.<\/p>\n

Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL\/6 mouse model.<\/a>
Sager TM, Wolfarth MW, Andrew M, Hubbs A, Friend S, Chen TH, Porter DW, Wu N, Yang F, Hamilton RF, Holian A.
Nanotoxicology. 2014 May;8(3):317-27. doi: 10.3109\/17435390.2013.779757. Epub 2013 Mar 19.<\/p>\n

Adult Onset Still’s\u00a0Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations.
<\/a>Antoniou KM, Margaritopoulos GA, Giannarakis I, Choulaki C, Fountoulakis N, Siafakas NM, Sidiropoulos P.
Case Rep Med. 2013;2013:981232. doi: 10.1155\/2013\/981232. Epub 2013 Jan 17.<\/p>\n

Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity.
<\/a>Li R, Wang X, Ji Z, Sun B, Zhang H, Chang CH, Lin S, Meng H, Liao YP, Wang M, Li Z, Hwang AA, Song TB, Xu R, Yang Y, Zink JI, Nel AE, Xia T.
ACS Nano. 2013 Mar 26;7(3):2352-68. doi: 10.1021\/nn305567s. Epub 2013 Feb 28.<\/p>\n

Silica induces\u00a0NLRP3\u00a0inflammasome activation in human\u00a0lung\u00a0epithelial cells.
<\/a>Peeters PM, Perkins TN, Wouters EF, Mossman BT, Reynaert NL.
Part Fibre Toxicol. 2013 Feb 12;10:3. doi: 10.1186\/1743-8977-10-3.<\/p>\n

Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome.
<\/a>Villegas LR, Kluck D, Field C, Oberley-Deegan RE, Woods C, Yeager ME, El Kasmi KC, Savani RC, Bowler RP, Nozik-Grayck E.
Antioxid Redox Signal. 2013 May 10;18(14):1753-64. doi: 10.1089\/ars.2012.4799. Epub 2013 Feb 5.<\/p>\n

Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation.
<\/a>Triantafilou K, Kar S, Vakakis E, Kotecha S, Triantafilou M.
Thorax. 2013 Jan;68(1):66-75. doi: 10.1136\/thoraxjnl-2012-202182.<\/p>\n

Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced\u00a0lung\u00a0injury.
<\/a>Kuipers MT, Aslami H, Vlaar AP, Juffermans NP, Tuip-de Boer AM, Hegeman MA, Jongsma G, Roelofs JJ, van der Poll T, Schultz MJ, Wieland CW.
PLoS One. 2012;7(11):e50559. doi: 10.1371\/journal.pone.0050559. Epub 2012 Nov 30.<\/p>\n

NLRP3\u00a0inflammasome activation in murine alveolar macrophages and related\u00a0lung\u00a0pathology is associated with MWCNT nickel contamination.
<\/a>Hamilton RF Jr, Buford M, Xiang C, Wu N, Holian A.
Inhal Toxicol. 2012 Dec;24(14):995-1008. doi: 10.3109\/08958378.2012.745633.<\/p>\n

Polymorphisms in inflammasome genes and risk of coal workers’ pneumoconiosis in a Chinese population.
<\/a>Ji X, Hou Z, Wang T, Jin K, Fan J, Luo C, Chen M, Han R, Ni C.
PLoS One. 2012;7(10):e47949. doi: 10.1371\/journal.pone.0047949. Epub 2012 Oct 22.<\/p>\n

IL-1R signalling is critical for regulation of multi-walled carbon nanotubes-induced acute\u00a0lunginflammation in C57Bl\/6 mice.
<\/a>Girtsman TA, Beamer CA, Wu N, Buford M, Holian A.
Nanotoxicology. 2014 Feb;8(1):17-27. doi: 10.3109\/17435390.2012.744110. Epub 2012 Nov 14.<\/p>\n

Hyaluronan activation of the\u00a0Nlrp3\u00a0inflammasome contributes to the development of airway hyperresponsiveness.
<\/a>Feng F, Li Z, Potts-Kant EN, Wu Y, Foster WM, Williams KL, Hollingsworth JW.
Environ Health Perspect. 2012 Dec;120(12):1692-8. doi: 10.1289\/ehp.1205188. Epub 2012 Sep 24. Retraction in:\u00a0Environ Health Perspect. 2015 Jul;123(7):A172<\/a>.<\/p>\n

NLRP3\u00a0suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases.
<\/a>Chow MT, Sceneay J, Paget C, Wong CS, Duret H, Tschopp J, M\u00f6ller A, Smyth MJ.
Cancer Res. 2012 Nov 15;72(22):5721-32. doi: 10.1158\/0008-5472.CAN-12-0509. Epub 2012 Sep 17.<\/p>\n

Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to\u00a0lungantibacterial responses.
<\/a>Dela Cruz CS, Liu W, He CH, Jacoby A, Gornitzky A, Ma B, Flavell R, Lee CG, Elias JA.
Cell Host Microbe. 2012 Jul 19;12(1):34-46. doi: 10.1016\/j.chom.2012.05.017.<\/p>\n

The Role of the\u00a0NLRP3\u00a0Inflammasome in Fibrosis.
<\/a>Artlett CM.
Open Rheumatol J. 2012;6:80-6. doi: 10.2174\/1874312901206010080. Epub 2012 Jun 15.<\/p>\n

NLRP1-dependent pyroptosis leads to acute\u00a0lung\u00a0injury and morbidity in mice.
<\/a>Kovarova M, Hesker PR, Jania L, Nguyen M, Snouwaert JN, Xiang Z, Lommatzsch SE, Huang MT, Ting JP, Koller BH.
J Immunol. 2012 Aug 15;189(4):2006-16. doi: 10.4049\/jimmunol.1201065. Epub 2012 Jun 29.<\/p>\n

Ventilator-induced\u00a0lung\u00a0injury is mediated by the\u00a0NLRP3\u00a0inflammasome.
<\/a>Kuipers MT, Aslami H, Janczy JR, van der Sluijs KF, Vlaar AP, Wolthuis EK, Choi G, Roelofs JJ, Flavell RA, Sutterwala FS, Bresser P, Leemans JC, van der Poll T, Schultz MJ, Wieland CW.
<\/span>Anesthesiology. 2012 May;116(5):1104-15. doi: 10.1097\/ALN.0b013e3182518bc0.<\/span><\/p>\n

Immunolocalization of\u00a0NLRP3\u00a0Inflammasome in Normal Murine Airway Epithelium and Changes following Induction of Ovalbumin-Induced Airway Inflammation.
<\/a>Tran HB, Lewis MD, Tan LW, Lester SE, Baker LM, Ng J, Hamilton-Bruce MA, Hill CL, Koblar SA, Rischmueller M, Ruffin RE, Wormald PJ, Zalewski PD, Lang CJ.
J Allergy (Cairo). 2012;2012:819176. doi: 10.1155\/2012\/819176. Epub 2012 Mar 18.<\/span><\/p>\n

Biological insights from clinical trials and networks.
<\/a>Thannickal VJ, Hagood JS.
Am J Respir Crit Care Med. 2012 Mar 1;185(5):475-6. doi: 10.1164\/rccm.201201-0047ED. No abstract available.<\/p>\n

Impaired\u00a0NLRP3\u00a0inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin.
<\/a>Stout-Delgado HW, Vaughan SE, Shirali AC, Jaramillo RJ, Harrod KS.
J Immunol. 2012 Mar 15;188(6):2815-24. doi: 10.4049\/jimmunol.1103051. Epub 2012 Feb 10.<\/p>\n

Analysis of\u00a0NLRP3\u00a0in the development of allergic airway\u00a0disease\u00a0in mice.
<\/a>Allen IC, Jania CM, Wilson JE, Tekeppe EM, Hua X, Brickey WJ, Kwan M, Koller BH, Tilley SL, Ting JP.
J Immunol. 2012 Mar 15;188(6):2884-93. doi: 10.4049\/jimmunol.1102488. Epub 2012 Feb 8.<\/p>\n

Staphylococcus aureus \u03b1-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the\u00a0NLRP3\u00a0inflammasome.
<\/a>Kebaier C, Chamberland RR, Allen IC, Gao X, Broglie PM, Hall JD, Jania C, Doerschuk CM, Tilley SL, Duncan JA.
J Infect Dis. 2012 Mar 1;205(5):807-17. doi: 10.1093\/infdis\/jir846. Epub 2012 Jan 25.<\/p>\n

Statins and pulmonary fibrosis: the potential role of\u00a0NLRP3\u00a0inflammasome activation.
<\/a>Xu JF, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Est\u00e9par RS, Diaz AA, Li HP, Qu JM, Himes BE, Come CE, D’Aco K, Martinez FJ, Han MK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AM, Hunninghake GM; COPDGene Investigators.
Am J Respir Crit Care Med. 2012 Mar 1;185(5):547-56. doi: 10.1164\/rccm.201108-1574OC. Epub 2012 Jan 12.<\/p>\n

Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei\u00a0lunginfection while IL-1\u03b2 is deleterious.
<\/a>Ceballos-Olvera I, Sahoo M, Miller MA, Del Barrio L, Re F.
PLoS Pathog. 2011 Dec;7(12):e1002452. doi: 10.1371\/journal.ppat.1002452. Epub 2011 Dec 29.<\/p>\n

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter.
<\/a>Hirota JA, Hirota SA, Warner SM, Stefanowicz D, Shaheen F, Beck PL, Macdonald JA, Hackett TL, Sin DD, Van Eeden S, Knight DA.
J Allergy Clin Immunol. 2012 Apr;129(4):1116-25.e6. doi: 10.1016\/j.jaci.2011.11.033. Epub 2012 Jan 9.<\/p>\n

Bench-to-bedside review: Damage-associated molecular patterns in the onset of ventilator-induced\u00a0lung\u00a0injury.
<\/a>Kuipers MT, van der Poll T, Schultz MJ, Wieland CW.
Crit Care. 2011;15(6):235. doi: 10.1186\/cc10437. Epub 2011 Nov 30. Review.<\/p>\n

NALP-3 inflammasome silencing attenuates ceramide-induced transepithelial permeability.
<\/a>Kolliputi N, Galam L, Parthasarathy PT, Tipparaju SM, Lockey RF.
J Cell Physiol. 2012 Sep;227(9):3310-6. doi: 10.1002\/jcp.24026.<\/p>\n

Inflammasome-IL-1-Th17 response in allergic\u00a0lung\u00a0inflammation.
<\/a>Besnard AG, Togbe D, Couillin I, Tan Z, Zheng SG, Erard F, Le Bert M, Quesniaux V, Ryffel B.
J Mol Cell Biol. 2012 Feb;4(1):3-10. doi: 10.1093\/jmcb\/mjr042. Epub 2011 Dec 6. Review.<\/p>\n

 <\/p>\n

A novel mutation of IL1RN in the deficiency of interleukin-1 receptor antagonist syndrome: description of two unrelated cases from Brazil.
<\/a>Jesus AA, Osman M, Silva CA, Kim PW, Pham TH, Gadina M, Yang B, Bertola DR, Carneiro-Sampaio M, Ferguson PJ, Renshaw BR, Schooley K, Brown M, Al-Dosari A, Al-Alami J, Sims JE, Goldbach-Mansky R, El-Shanti H.
Arthritis Rheum. 2011 Dec;63(12):4007-17. doi: 10.1002\/art.30588.<\/p>\n

Activation of the\u00a0NLRP3\u00a0inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis.
<\/a>Dorhoi A, Nouailles G, J\u00f6rg S, Hagens K, Heinemann E, Pradl L, Oberbeck-M\u00fcller D, Duque-Correa MA, Reece ST, Ruland J, Brosch R, Tschopp J, Gross O, Kaufmann SH.
Eur J Immunol. 2012 Feb;42(2):374-84. doi: 10.1002\/eji.201141548. Epub 2011 Dec 20.<\/p>\n

Hemorrhagic shock activation of\u00a0NLRP3\u00a0inflammasome in\u00a0lung\u00a0endothelial cells.
<\/a>Xiang M, Shi X, Li Y, Xu J, Yin L, Xiao G, Scott MJ, Billiar TR, Wilson MA, Fan J.
J Immunol. 2011 Nov 1;187(9):4809-17. doi: 10.4049\/jimmunol.1102093. Epub 2011 Sep 21.<\/p>\n

IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis.
<\/a>Gasse P, Riteau N, Vacher R, Michel ML, Fautrel A, di Padova F, Fick L, Charron S, Lagente V, Eberl G, Le Bert M, Quesniaux VF, Huaux F, Leite-de-Moraes M, Ryffel B, Couillin I.
PLoS One. 2011;6(8):e23185. doi: 10.1371\/journal.pone.0023185. Epub 2011 Aug 16.<\/p>\n

NLRP3\/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation.
<\/a>Provoost S, Maes T, Pauwels NS, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Tournoy KG.
J Immunol. 2011 Sep 15;187(6):3331-7. doi: 10.4049\/jimmunol.1004062. Epub 2011 Aug 15.<\/p>\n

The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis.
<\/a>Artlett CM, Sassi-Gaha S, Rieger JL, Boesteanu AC, Feghali-Bostwick CA, Katsikis PD.
Arthritis Rheum. 2011 Nov;63(11):3563-74. doi: 10.1002\/art.30568.<\/p>\n

Caspase-1 dependent IL-1\u03b2 secretion is critical for host defense in a mouse model of Chlamydia pneumoniae\u00a0lung\u00a0infection.
<\/a>Shimada K, Crother TR, Karlin J, Chen S, Chiba N, Ramanujan VK, Vergnes L, Ojcius DM, Arditi M.
PLoS One. 2011;6(6):e21477. doi: 10.1371\/journal.pone.0021477. Epub 2011 Jun 23.<\/p>\n

The\u00a0NLRP3\u00a0inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia.
<\/a>Witzenrath M, Pache F, Lorenz D, Koppe U, Gutbier B, Tabeling C, Reppe K, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.
J Immunol. 2011 Jul 1;187(1):434-40. doi: 10.4049\/jimmunol.1003143. Epub 2011 Jun 6.<\/p>\n

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.
<\/a>Chang YJ, Kim HY, Albacker LA, Baumgarth N, McKenzie AN, Smith DE, Dekruyff RH, Umetsu DT.
Nat Immunol. 2011 May 29;12(7):631-8. doi: 10.1038\/ni.2045.<\/p>\n

Serum amyloid A activates the\u00a0NLRP3\u00a0inflammasome and promotes Th17 allergic asthma in mice.
<\/a>Ather JL, Ckless K, Martin R, Foley KL, Suratt BT, Boyson JE, Fitzgerald KA, Flavell RA, Eisenbarth SC, Poynter ME.
J Immunol. 2011 Jul 1;187(1):64-73. doi: 10.4049\/jimmunol.1100500. Epub 2011 May 27.<\/p>\n

Role of IL-1\u03b1 and the\u00a0Nlrp3\/caspase-1\/IL-1\u03b2 axis in cigarette smoke-induced pulmonary inflammation and COPD.
<\/a>Pauwels NS, Bracke KR, Dupont LL, Van Pottelberge GR, Provoost S, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Brusselle GG.
Eur Respir J. 2011 Nov;38(5):1019-28. doi: 10.1183\/09031936.00158110. Epub 2011 May 26.<\/p>\n

An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma.
<\/a>Kool M, Willart MA, van Nimwegen M, Bergen I, Pouliot P, Virchow JC, Rogers N, Osorio F, Reis e Sousa C, Hammad H, Lambrecht BN.
Immunity. 2011 Apr 22;34(4):527-40. doi: 10.1016\/j.immuni.2011.03.015. Epub 2011 Apr 7. Erratum in: Immunity. 2011 Apr 22;34(4):627. Reis E Sousa, Caetano [corrected to Reis e Sousa, Caetano]..<\/p>\n

Toll-like receptor, RIG-I-like receptors and the\u00a0NLRP3\u00a0inflammasome: key modulators of innate immune responses to double-stranded RNA viruses.
<\/a>Yu M, Levine SJ.
Cytokine Growth Factor Rev. 2011 Apr;22(2):63-72. doi: 10.1016\/j.cytogfr.2011.02.001. Epub 2011 Apr 3. Review.<\/p>\n

NLRP3\u00a0inflammasome is required in murine asthma in the absence of aluminum adjuvant.
<\/a>Besnard AG, Guillou N, Tschopp J, Erard F, Couillin I, Iwakura Y, Quesniaux V, Ryffel B, Togbe D.
Allergy. 2011 Aug;66(8):1047-57. doi: 10.1111\/j.1398-9995.2011.02586.x. Epub 2011 Mar 28.<\/p>\n

TLR9 and the\u00a0NLRP3\u00a0inflammasome link acinar cell death with inflammation in acute pancreatitis.
<\/a>Hoque R, Sohail M, Malik A, Sarwar S, Luo Y, Shah A, Barrat F, Flavell R, Gorelick F, Husain S, Mehal W.
Gastroenterology. 2011 Jul;141(1):358-69. doi: 10.1053\/j.gastro.2011.03.041. Epub 2011 Mar 24.<\/p>\n

The role of the\u00a0NLRP3\u00a0inflammasome in the pathogenesis of airway\u00a0disease.
<\/a>Birrell MA, Eltom S.
Pharmacol Ther. 2011 Jun;130(3):364-70. doi: 10.1016\/j.pharmthera.2011.03.007. Epub 2011 Mar 21. Review.<\/p>\n

Proposed pathobiologic mechanisms of hypoxia-ischemia-reperfusion in corticosteroid-resistant neutrophilic asthma and consideration of interleukin 1 targeted therapy.
<\/a>Wanderer AA.
Ann Allergy Asthma Immunol. 2011 Jan;106(1):69-72. doi: 10.1016\/j.anai.2010.09.007. No abstract available.<\/p>\n

[Progress in research on role of inflammasome Nalp3 in silica dusts induced body injuries].
<\/a>Zhou Y, Zhou T, Guo JL.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010 Oct;28(10):795-8. Review. Chinese. No abstract available.<\/p>\n

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1\u03b1 and IL-1\u03b2.
<\/a>Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, Tschopp J.
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19449-54. doi: 10.1073\/pnas.1008155107. Epub 2010 Oct 25.<\/p>\n

[Immunological effects of silica\/asbestos].
<\/a>Kumagai N, Nishimura Y, Maeda M, Hayashi H, Otsuki T.
<\/span>Nihon Eiseigaku Zasshi. 2010 Sep;65(4):493-9. Review. Japanese.<\/p>\n

Inflammasome-mediated autoinflammatory disorders.
<\/a>Wilson SP, Cassel SL.
Postgrad Med. 2010 Sep;122(5):125-33. doi: 10.3810\/pgm.2010.09.2209. Review.<\/p>\n

Airborne Asian sand dust enhances murine\u00a0lung\u00a0eosinophilia.
<\/a>He M, Ichinose T, Yoshida S, Nishikawa M, Mori I, Yanagisawa R, Takano H, Inoue K, Sun G, Shibamoto T.
Inhal Toxicol. 2010 Oct;22(12):1012-25. doi: 10.3109\/08958378.2010.510151.<\/p>\n

Monogenic autoinflammatory\u00a0diseases: new insights into clinical aspects and pathogenesis.
<\/a>Henderson C, Goldbach-Mansky R.
Curr Opin Rheumatol. 2010 Sep;22(5):567-78. doi: 10.1097\/BOR.0b013e32833ceff4. Review.<\/p>\n

NALP3 is not necessary for early protection against experimental tuberculosis.
<\/a>Walter K, H\u00f6lscher C, Tschopp J, Ehlers S.
Immunobiology. 2010 Sep-Oct;215(9-10):804-11. doi: 10.1016\/j.imbio.2010.05.015. Epub 2010 Jun 4.<\/p>\n

Extracellular ATP is a danger signal activating P2X7 receptor in\u00a0lung\u00a0inflammation and fibrosis.
<\/a>Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, Fick L, Kanellopoulos J, Quesniaux VF, Marchand-Adam S, Crestani B, Ryffel B, Couillin I.
Am J Respir Crit Care Med. 2010 Sep 15;182(6):774-83. doi: 10.1164\/rccm.201003-0359OC. Epub 2010 Jun 3.<\/p>\n

Inflammasome and IL-1beta-mediated disorders.
<\/a>Hoffman HM, Wanderer AA.
Curr Allergy Asthma Rep. 2010 Jul;10(4):229-35. doi: 10.1007\/s11882-010-0109-z. Review.<\/p>\n

Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the\u00a0NLRP3\/ASC inflammasome.
<\/a>He X, Mekasha S, Mavrogiorgos N, Fitzgerald KA, Lien E, Ingalls RR.
J Immunol. 2010 May 15;184(10):5743-54. doi: 10.4049\/jimmunol.0903937. Epub 2010 Apr 14.<\/p>\n

NLRP3\u00a0(NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways.
<\/a>Willingham SB, Allen IC, Bergstralh DT, Brickey WJ, Huang MT, Taxman DJ, Duncan JA, Ting JP.
J Immunol. 2009 Aug 1;183(3):2008-15. doi: 10.4049\/jimmunol.0900138. Epub 2009 Jul 8.<\/p>\n

The intracellular sensor\u00a0NLRP3\u00a0mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.
<\/a>Thomas PG, Dash P, Aldridge JR Jr, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD.
Immunity. 2009 Apr 17;30(4):566-75. doi: 10.1016\/j.immuni.2009.02.006. Epub 2009 Apr 9.<\/p>\n

Uric acid is a danger signal activating NALP3 inflammasome in\u00a0lung\u00a0injury inflammation and fibrosis.
<\/a>Gasse P, Riteau N, Charron S, Girre S, Fick L, P\u00e9trilli V, Tschopp J, Lagente V, Quesniaux VF, Ryffel B, Couillin I.
Am J Respir Crit Care Med. 2009 May 15;179(10):903-13. doi: 10.1164\/rccm.200808-1274OC. Epub 2009 Feb 12.<\/p>\n

Interleukin-1beta targeted therapy in severe persistent asthma (SPA) and chronic obstructive pulmonary\u00a0disease\u00a0(COPD): proposed similarities between biphasic pathobiology of SPA\/COPD and ischemia-reperfusion injury.
<\/a>Wanderer AA.
Isr Med Assoc J. 2008 Dec;10(12):837-42.<\/p>\n

Smoke particulates stress\u00a0lung\u00a0cells.
<\/a>Adair-Kirk TL, Atkinson JJ, Senior RM.
Nat Med. 2008 Oct;14(10):1024-5. doi: 10.1038\/nm1008-1024. No abstract available.<\/p>\n

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
<\/a>Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E.
Nat Immunol. 2008 Aug;9(8):847-56. doi: 10.1038\/ni.1631. Epub 2008 Jul 11.<\/p>\n

The Nalp3 inflammasome is essential for the development of silicosis.
<\/a>Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS.
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9035-40. doi: 10.1073\/pnas.0803933105. Epub 2008 Jun 24.<\/p>\n

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
<\/a>Dostert C, P\u00e9trilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J.
Science. 2008 May 2;320(5876):674-7. doi: 10.1126\/science.1156995. Epub 2008 Apr 10.<\/p>\n

Induction of toll-like receptors and NALP\/PAN\/PYPAF family members by modified oligonucleotides in\u00a0lung\u00a0epithelial carcinoma cells.
<\/a>Drygin D, Koo S, Perera R, Barone S, Bennett CF.
Oligonucleotides. 2005 Summer;15(2):105-18.<\/p>\n

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[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″] Lung Disease and NLRP3   Sphingosine signaling dysfunction in airway cells as a potential contributor to progression from protracted bacterial bronchitis […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/924"}],"collection":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/comments?post=924"}],"version-history":[{"count":6,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/924\/revisions"}],"predecessor-version":[{"id":935,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/924\/revisions\/935"}],"wp:attachment":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/media?parent=924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}