{"id":917,"date":"2020-04-09T19:57:59","date_gmt":"2020-04-09T19:57:59","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=917"},"modified":"2020-04-10T02:32:13","modified_gmt":"2020-04-10T02:32:13","slug":"obesity-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/obesity-and-nlrp3\/","title":{"rendered":"Obesity and NLRP3"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″]<\/p>\n

Obesity and NLRP3<\/strong><\/span><\/h4>\n

 <\/p>\n

Sleeve Gastroplasty Combined with the\u00a0NLRP3\u00a0Inflammasome Inhibitor CY-09 Reduces Body Weight, Improves Insulin Resistance and Alleviates Hepatic Steatosis in Mouse Model.<\/a>
Sun K, Wang J, Lan Z, Li L, Wang Y, Li A, Liu S, Li Y.
Obes Surg. 2020 Apr 8.\u00a0doi<\/g>: 10.1007\/s11695-020-04571-8. [Epub ahead of print]<\/p>\n

UCP2, IL18, and miR-133a-3p are dysregulated in subcutaneous adipose tissue of patients with\u00a0obesity.<\/a>
Oliveira MS, Rheinheimer J, Moehlecke M, Rodrigues M, Assmann TS, Leit\u00e3o CB, Trindade MRM, Crispim D, de Souza BM.
Mol Cell Endocrinol. 2020 Apr 3:110805.\u00a0doi<\/g>: 10.1016\/j.mce.2020.110805. [Epub ahead of print]<\/p>\n

Knockout<\/g>\u00a0of MD1 contributes to sympathetic hyperactivity and exacerbates ventricular arrhythmias following heart failure with preserved ejection fraction via\u00a0NLRP3\u00a0inflammasome activation.<\/a>
Yang HJ, Kong B, Shuai W, Zhang JJ, Huang H.
Exp Physiol. 2020 Apr 2.\u00a0doi<\/g>: 10.1113\/EP088390. [Epub ahead of print]<\/p>\n

Immunometabolism: a key target to improve microcirculation in\u00a0ageing<\/g>.<\/a>
Abdellatif M, Zirlik A.
Cardiovasc Res. 2020 Apr 1;116(3):e48-e50. doi: 10.1093\/cvr\/cvaa060. No abstract available.<\/p>\n

Visfatin\/eNampt<\/g>\u00a0induces endothelial dysfunction in vivo: a role for Toll-Like Receptor 4 and\u00a0NLRP3inflammasome.<\/a>
Romacho T, Valencia I, Ramos-Gonz\u00e1lez M, Vallejo S, L\u00f3pez-Esteban M, Lorenzo O, Cannata P, Romero A, San Hip\u00f3lito-Luengo A, G\u00f3mez-Cerezo JF, Peir\u00f3 C, S\u00e1nchez-Ferrer CF.
Sci Rep. 2020 Mar 25;10(1):5386. doi: 10.1038\/s41598-020-62190-w.<\/p>\n

The Impact of Acute Ingestion of a Ketone Monoester Drink on LPS-Stimulated\u00a0NLRP3\u00a0Activation in Humans with\u00a0Obesity.<\/a>
Neudorf H, Myette-C\u00f4t\u00e9 \u00c9, P Little J.
Nutrients. 2020 Mar 23;12(3). pii: E854. doi: 10.3390\/nu12030854.<\/p>\n

The\u00a0NLRP3\u00a0inflammasome regulates adipose tissue metabolism.<\/a>
Barra NG, Henriksbo BD, Anh\u00ea FF, Schertzer JD.
Biochem J. 2020 Mar 27;477(6):1089-1107. doi: 10.1042\/BCJ20190472.<\/p>\n

Palmitic acid activates\u00a0NLRP3<\/g>\u00a0inflammasome and induces placental inflammation during pregnancy in mice.
<\/a>Sano M, Shimazaki S, Kaneko Y, Karasawa T, Takahashi M, Ohkuchi A, Takahashi H, Kurosawa A, Torii Y, Iwata H, Kuwayama T, Shirasuna K.
J Reprod Dev. 2020 Feb 27.\u00a0doi<\/g>: 10.1262\/jrd.2020-007. [Epub ahead of print]<\/p>\n

MicroRNA Profiling in Adipose Before and After Weight Loss Highlights the Role of miR-223-3p and the\u00a0NLRP3\u00a0Inflammasome.
<\/a>Macartney-Coxson D, Danielson K, Clapham J, Benton MC, Johnston A, Jones A, Shaw O, Hagan RD, Hoffman EP, Hayes M, Harper J, Langston MA, Stubbs RS.
Obesity\u00a0(Silver Spring). 2020 Mar;28(3):570-580.\u00a0doi<\/g>: 10.1002\/oby.22722\u00a0<\/p>\n

Geniposide protects against sepsis-induced myocardial dysfunction through\u00a0AMPK\u03b1-dependent<\/g>\u00a0pathway.
<\/a>Song P, Shen DF, Meng YY, Kong CY, Zhang X, Yuan YP, Yan L, Tang QZ, Ma ZG.
Free Radic Biol Med. 2020 Feb 17;152:186-196.\u00a0doi<\/g>: 10.1016\/j.freeradbiomed.2020.02.011. [Epub ahead of print]<\/p>\n

The effect of quantity and quality of dietary fat intake on subcutaneous white adipose tissue inflammatory responses.
<\/a>Dewhurst-Trigg R, Hulston CJ, Markey O.
Proc Nutr Soc. 2020 Feb 17:1-15.\u00a0doi<\/g>: 10.1017\/S0029665120000038. [Epub ahead of print]<\/p>\n

The Molecular Mechanisms of Excessive Hippocampal Endoplasmic Reticulum Stress Depressing Cognition-related Proteins Expression and the Regulatory Effects of Nrf2.
<\/a>Cai M, Hu JY, Liu BB, Li JJ, Li F, Lou S.
Neuroscience. 2020 Apr 1;431:152-165. doi: 10.1016\/j.neuroscience.2020.02.001. Epub 2020 Feb 14.<\/p>\n

Palmitate induces apoptotic cell death and inflammasome activation in human placental macrophages.
<\/a>Rogers LM, Serezani CH, Eastman AJ, Hasty AH, Englund-\u00d6gge L, Jacobsson B, Vickers KC, Aronoff DM.
Placenta. 2020 Jan 15;90:45-51. doi: 10.1016\/j.placenta.2019.12.009. Epub 2019 Dec 9.<\/p>\n

Emerging therapeutic targets for NASH: key innovations at the preclinical level.
<\/a>Horn P, Newsome PN.
Expert Opin Ther Targets. 2020 Mar;24(3):175-186.\u00a0doi<\/g>: 10.1080\/14728222.2020.1728742. Epub 2020 Feb 13.<\/p>\n

Mice Deficient in the IL-1\u03b2 Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of\u00a0Obesity-Induced NAFLD.
<\/a>Mirea AM, Stienstra R, Kanneganti TD, Tack CJ, Chavakis T, Toonen EJM, Joosten LAB.
Inflammation. 2020 Jan 30.\u00a0doi<\/g>: 10.1007\/s10753-020-01190-4. [Epub ahead of print]<\/p>\n

Absence of the Caspases 1\/11 Modulates Liver Global Lipid Profile and Gut Microbiota in High-Fat-Diet-Induced Obese Mice.
<\/a>de Sant’Ana LP, Ribeiro DJS, Martins AMA, Dos Santos FN, Corr\u00eaa R, Almeida RDN, Eberlin MN, Maurice CF, Magalh\u00e3es KG.
Front Immunol. 2020 Jan 9;10:2926.\u00a0doi<\/g>: 10.3389\/fimmu.2019.02926. eCollection 2019.<\/p>\n

Blockade<\/g>\u00a0of the\u00a0NLRP3\u00a0inflammasome improves metabolic health and lifespan in obese mice.
<\/a>Ca\u00f1adas-Lozano D, Mar\u00edn-Aguilar F, Castej\u00f3n-Vega B, Ryffel B, Navarro-Pando JM, Ruiz-Cabello J, Alcocer-G\u00f3mez E, Bull\u00f3n P, Cordero MD.
Geroscience. 2020 Jan 23.\u00a0doi<\/g>: 10.1007\/s11357-019-00151-6. [Epub ahead of print]<\/p>\n

PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting\u00a0NLRP3inflammasome activation in mice.
<\/a>Sun CC, Zhang CY, Duan\u00a0JX<\/g>, Guan XX, Yang HH, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX, Liu SK, Zhang J.
Biochem Biophys Res Commun. 2020 Mar 19;523(4):1020-1026.\u00a0doi<\/g>: 10.1016\/j.bbrc.2019.12.131. Epub 2020 Jan 20.<\/p>\n

Neutrophil Extracellular Traps and Cardiovascular Diseases: An Update.
<\/a>Bonaventura A, Vecchi\u00e9 A, Abbate A, Montecucco F.
Cells. 2020 Jan 17;9(1).\u00a0pii<\/g>: E231.\u00a0doi<\/g>: 10.3390\/cells9010231. Review.<\/p>\n

Visceral adipose\u00a0NLRP3\u00a0impairs cognition in\u00a0obesity\u00a0via IL-1R1 on CX3CR1+ cells.
<\/a>Guo DH, Yamamoto M, Hernandez CM, Khodadadi H, Baban B, Stranahan AM.
J Clin Invest. 2020 Apr 1;130(4):1961-1976. doi: 10.1172\/JCI126078.\u00a0<\/p>\n

Redox status, inflammation, necroptosis and inflammasome as indispensable contributors to\u00a0high fat<\/g>\u00a0diet (HFD)-induced neurodegeneration; Effect of N-acetylcysteine (NAC).
<\/a>Keshk WA, Ibrahim MA, Shalaby SM, Zalat ZA, Elseady WS.
Arch Biochem Biophys. 2020 Feb 15;680:108227.\u00a0doi: 10.1016\/j.abb.2019.108227. Epub 2019 Dec 12\u00a0<\/p>\n

Red Raspberry Polyphenols Attenuate High-Fat Diet-Driven Activation of\u00a0NLRP3\u00a0Inflammasome and its Paracrine Suppression of Adipogenesis via Histone Modifications.
<\/a>Fan R, You M, Toney AM, Kim J, Giraud D, Xian Y, Ye F, Gu L, Ramer-Tait AE, Chung S.
Mol Nutr Food Res. 2019 Dec 1:e1900995.\u00a0doi<\/g>: 10.1002\/mnfr.201900995. [Epub ahead of print]\u00a0<\/p>\n

CD8+<\/sub>\u00a0T cell\/adipocyte inflammatory\u00a0cross talk<\/g>\u00a0and ensuing M1 macrophage polarization are reduced by fish-oil-derived n-3 polyunsaturated fatty acids, in part by a TNF-\u03b1-dependent mechanism.
<\/a>Liddle DM, Monk JM, Hutchinson AL, Ma DWL, Robinson LE.
J Nutr Biochem. 2020 Feb;76:108243. doi: 10.1016\/j.jnutbio.2019.108243. Epub 2019 Oct 24<\/p>\n

AdipoRon Alleviates Free Fatty Acid-Induced Myocardial Cell Injury Via Suppressing\u00a0Nlrp3Inflammasome Activation.
<\/a>Zhang YZ, Zhang YL, Huang Q, Huang C, Jiang ZL, Cai F, Shen JF.
Diabetes Metab Syndr Obes. 2019 Oct 23;12:2165-2179. doi: 10.2147\/DMSO.S221841. eCollection 2019.<\/p>\n

Calcium sensing receptor activation in THP-1 macrophages triggers\u00a0NLRP3\u00a0inflammasome and human preadipose cell inflammation.
<\/a>D’Espessailles A, Santillana N, Sanhueza S, Fuentes C, Cifuentes M.
Mol Cell Endocrinol. 2020 Feb 5;501:110654. doi: 10.1016\/j.mce.2019.110654. Epub 2019 Nov 15.<\/p>\n

Integrating complement into the molecular pathogenesis of Hidradenitis Suppurativa.
<\/a>Grand D, Navrazhina K, Frew JW.
Exp Dermatol. 2020 Jan;29(1):86-92. doi: 10.1111\/exd.14056. Epub 2019 Nov 29.<\/p>\n

Corrigendum to “CD36-Mediated Lipid Accumulation and Activation of\u00a0NLRP3\u00a0Inflammasome Lead to Podocyte Injury in\u00a0Obesity-Related Glomerulopathy”.
<\/a>Zhao J, Rui HL, Yang M, Sun LJ, Dong HR, Cheng H.
Mediators Inflamm. 2019 Sep 23;2019:8247280. doi: 10.1155\/2019\/8247280. eCollection 2019. m<\/p>\n

Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells.
<\/a>Zhang Y, Wang YT, Koka S, Zhang Y, Hussain T, Li X.
Front Biosci (Landmark Ed). 2020 Jan 1;25:283-298.<\/p>\n

NLRP3\u00a0Inflammasome: A Novel Player in Metabolically Induced Inflammation-Potential Influence on the Myocardium.
<\/a>Sokolova M, Ranheim T, Louwe MC, Halvorsen B, Yndestad A, Aukrust P.
J Cardiovasc Pharmacol. 2019 Oct;74(4):276-284.\u00a0doi<\/g>: 10.1097\/FJC.0000000000000704.<\/p>\n

Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny.
<\/a>Adams RCM, Smith C.
Mediators Inflamm. 2019 Aug 25;2019:9160941. doi: 10.1155\/2019\/9160941. eCollection 2019.<\/p>\n

Nlrp1b1 negatively modulates\u00a0obesity-induced inflammation by promoting IL-18 production.
<\/a>Salazar-Le\u00f3n J, Valdez-Hern\u00e1ndez AL, Garc\u00eda-Jim\u00e9nez S, Rom\u00e1n-Dom\u00ednguez L, Huanosta-Murillo E, Bonifaz LC, P\u00e9rez-Mart\u00ednez L, Pedraza-Alva G.
Sci Rep. 2019 Sep 25;9(1):13815. doi: 10.1038\/s41598-019-49546-7.<\/p>\n

NLRP3\u00a0inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling.
<\/a>Unamuno X, G\u00f3mez-Ambrosi J, Ram\u00edrez B, Rodr\u00edguez A, Becerril S, Valent\u00ed V, Moncada R, Silva C, Salvador J, Fr\u00fchbeck G, Catal\u00e1n V.
Cell Mol Immunol. 2019 Sep 24.\u00a0doi<\/g>: 10.1038\/s41423-019-0296-z. [Epub ahead of print]<\/p>\n

Methanogenic Archaea: Emerging Partners in the Field of Allergic Diseases.
<\/a>Sereme Y, Mezouar S, Grine G, Mege JL, Drancourt M, Corbeau P, Vitte J.
Clin Rev Allergy Immunol. 2019 Dec;57(3):456-466. doi: 10.1007\/s12016-019-08766-5. Review.<\/p>\n

Compound C Protects Mice from HFD-Induced\u00a0Obesity\u00a0and Nonalcoholic Fatty Liver Disease.
<\/a>Wang F, Liu Y, Yuan J, Yang W, Mo Z.
Int J Endocrinol. 2019 Aug 14;2019:3206587.\u00a0doi<\/g>: 10.1155\/2019\/3206587. eCollection 2019.<\/p>\n

[Role of Angiogenesis and Chronic Inflammation in Fat Hypertrophy in NASH Pathology].
<\/a>Wada T, Tsuneki H, Sasaoka T.
Yakugaku Zasshi. 2019;139(9):1163-1167.\u00a0doi<\/g>: 10.1248\/yakushi.19-00011-3. Review. Japanese.<\/p>\n

Compound C attenuates\u00a0NLRP3\u00a0inflammasome despite AMPK knockdown in LPS plus palmitate-induced THP-1 cells.
<\/g><\/a>Liu<\/g> Y, He H, Fan L, Yuan J, Huang H, Yang W, Wang L, Mo Z, Wang F.
Naunyn Schmiedebergs Arch Pharmacol. 2020 Jan;393(1):67-76. doi: 10.1007\/s00210-019-01712-4. Epub 2019 Aug 16.<\/p>\n

Podocyte\u00a0NLRP3\u00a0Inflammasome Activation and Formation by Adipokine Visfatin.
<\/a>Koka S, Xia M, Zhang C, Zhang Y, Li PL,\u00a0Boini<\/g>\u00a0KM.
Cell Physiol Biochem. 2019;53(2):355-365.\u00a0doi<\/g>: 10.33594\/000000143.<\/p>\n

NLRP3\u00a0Inflammasome Promotes Myocardial Remodeling During Diet-Induced\u00a0Obesity.
<\/a>Sokolova M, Sjaastad I, Louwe MC, Alfsnes K, Aronsen JM, Zhang L, Haugstad SB, Bendiksen BA, \u00d8gaard J, Bliks\u00f8en M, Lien E, Berge RK, Aukrust P, Ranheim T, Yndestad A.
Front Immunol. 2019 Jul 16;10:1621.\u00a0doi<\/g>: 10.3389\/fimmu.2019.01621. eCollection 2019.<\/p>\n

The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms.
<\/a>Korbecki J, Bajdak-Rusinek K.
Inflamm Res. 2019 Nov;68(11):915-932.\u00a0doi<\/g>: 10.1007\/s00011-019-01273-5. Epub 2019 Jul 30. Review.<\/p>\n

NLRP3\u00a0inflammasome: a novel player in metabolically-induced inflammation – potential influence on the myocardium.
<\/a>Sokolova M, Ranheim T, Louwe MC, Halvorsen B, Yndestad A, Aukrust P.
J Cardiovasc Pharmacol. 2019 Jul 22.\u00a0doi<\/g>: 10.1097\/FJC.0000000000000704. [Epub ahead of print]<\/p>\n

Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications.
<\/a>Zeng C, Wang R, Tan H.
Int J Biol Sci. 2019 May 20;15(7):1345-1357. doi: 10.7150\/ijbs.33568. eCollection 2019. Review.<\/p>\n

Nebivolol improves\u00a0obesity-induced vascular\u00a0remodelling<\/g>\u00a0by suppressing\u00a0NLRP3\u00a0activation.
<\/a>Gao J, Xie Q, Wei T, Huang C, Zhou W, Shen W.
J Cardiovasc Pharmacol. 2019 Mar 14.\u00a0doi<\/g>: 10.1097\/FJC.0000000000000667. [Epub ahead of print]<\/p>\n

Celastrol attenuates ox-LDL-induced mesangial cell proliferation via suppressing\u00a0NLRP3inflammasome activation.
<\/a>Sun Z, Li Y, Qian Y, Wu M, Huang S, Zhang A, Zhang Y, Jia Z.
Cell Death Discov. 2019 Jul 5;5:114. doi: 10.1038\/s41420-019-0196-0. eCollection 2019.<\/p>\n

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory\u00a0inflammasomopathy<\/g>.
<\/a>G\u00f6\u00f6s H, Fogarty CL, Sahu B, Plagnol V, Rajam\u00e4ki K, Nurmi K, Liu X, Einarsdottir E, Jouppila A, Pettersson T, Vihinen H, Krjutskov K, Saavalainen P, J\u00e4rvinen A, Muurinen M, Greco D, Scala G, Curtis J, Nordstr\u00f6m D, Flaumenhaft R, Vaarala O, Kovanen PE, Keskitalo S, Ranki A, Kere J, Lehto M, Notarangelo LD, Nejentsev S, Eklund KK, Varjosalo M, Taipale J, Sepp\u00e4nen MRJ.
J Allergy Clin Immunol. 2019 Nov;144(5):1364-1376.\u00a0doi<\/g>: 10.1016\/j.jaci.2019.06.003. Epub 2019 Jun 13.<\/p>\n

Phytochemicals as Novel Therapeutic Strategies for\u00a0NLRP3\u00a0Inflammasome-Related Neurological, Metabolic, and Inflammatory Diseases.
<\/a>Pellegrini C, Fornai M, Antonioli L, Blandizzi C, Calderone V.
Int J Mol Sci. 2019 Jun 13;20(12).\u00a0pii<\/g>: E2876.\u00a0doi<\/g>: 10.3390\/ijms20122876. Review.<\/p>\n

Interleukin-1\u03b2 Inhibition for Chronic Kidney Disease in Obese Mice With Type 2 Diabetes.
<\/a>Lei Y, Devarapu SK, Motrapu M, Cohen CD, Lindenmeyer MT, Moll S, Kumar SV, Anders HJ.
Front Immunol. 2019 May 29;10:1223. doi: 10.3389\/fimmu.2019.01223. eCollection 2019.<\/p>\n

Frontline Science: Acyl-CoA synthetase 1 exacerbates lipotoxic inflammasome activation in primary macrophages.
<\/a>Kalugotla G, He L, Weber KJ, Daemen S, Reller A, Razani B, Schilling JD.
J Leukoc Biol. 2019 Oct;106(4):803-814.\u00a0doi<\/g>: 10.1002\/JLB.3HI0219-045RR. Epub 2019 Jun 5.<\/p>\n

Prospective analyses of white adipose tissue gene expression in relation to long-term body weight changes.
<\/a>Kwok KHM, Ryd\u00e9n M, Andersson DP, Beauchef G, Guere C, Vie K, Bergman O, Lundb\u00e4ck V, Arner P, Dahlman I.
Int J Obes (Lond). 2020 Feb;44(2):377-387.\u00a0doi<\/g>: 10.1038\/s41366-019-0385-1. Epub 2019 Jun 4.<\/p>\n

CD36-Mediated Lipid Accumulation and Activation of\u00a0NLRP3\u00a0Inflammasome Lead to Podocyte Injury in\u00a0Obesity-Related Glomerulopathy.
<\/a>Zhao J, Rui HL, Yang M, Sun LJ, Dong HR, Cheng H.
Mediators Inflamm. 2019 Apr 11;2019:3172647. doi: 10.1155\/2019\/3172647. eCollection 2019. Erratum in:\u00a0Mediators Inflamm. 2019 Sep 23;2019:8247280<\/a>.<\/p>\n

Nebivolol Improves\u00a0Obesity-Induced Vascular Remodeling by Suppressing\u00a0NLRP3\u00a0Activation.
<\/a>Gao J, Xie Q, Wei T, Huang C, Zhou W, Shen W.
J Cardiovasc Pharmacol. 2019 May;73(5):326-333.\u00a0doi<\/g>: 10.1097\/FJC.0000000000000667.<\/p>\n

Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation.
<\/a>Ge C, Xu M, Qin Y, Gu T, Lou D, Li Q, Hu L, Nie X, Wang M, Tan J.
Food Funct. 2019 May 22;10(5):2970-2985. doi: 10.1039\/c8fo01653d.<\/p>\n

Momordica charantia (bitter melon) modulates adipose tissue inflammasome gene expression and adipose-gut inflammatory\u00a0cross talk<\/g>\u00a0in high-fat diet (HFD)-fed mice.
<\/a>Nerurkar PV, Orias D, Soares N, Kumar M, Nerurkar VR.
J Nutr Biochem. 2019 Jun;68:16-32. doi: 10.1016\/j.jnutbio.2019.03.003. Epub 2019 Mar 23.<\/p>\n

Carbenoxolone ameliorates insulin sensitivity in obese mice induced by\u00a0high fat<\/g>\u00a0diet via regulating the I\u03baB-\u03b1\/NF-\u03baB pathway and\u00a0NLRP3\u00a0inflammasome.
<\/a>Chen Y, Qian Q, Yu J.
Biomed Pharmacother. 2019 Jul;115:108868.\u00a0doi<\/g>: 10.1016\/j.biopha.2019.108868. Epub 2019 Apr 15.<\/p>\n

The negative effect of lipid challenge on autophagy inhibits T cell responses.
<\/a>Guerrero-Ros I, Clement CC, Reynolds CA, Patel B, Santambrogio L, Cuervo AM, Macian F.
Autophagy. 2020 Feb;16(2):223-238.\u00a0doi<\/g>: 10.1080\/15548627.2019.1606635. Epub 2019 Apr 25.<\/p>\n

Saturated fatty acids induce\u00a0NLRP3\u00a0activation in human macrophages through K+<\/sub>\u00a0efflux resulting from phospholipid saturation and Na, K-ATPase disruption.
<\/a>Gianfrancesco MA, Dehairs J, L’homme L, Herinckx G, Esser N, Jansen O, Habraken Y, Lassence C, Swinnen JV, Rider MH, Piette J, Paquot N, Legrand-Poels S.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul;1864(7):1017-1030.\u00a0doi<\/g>: 10.1016\/j.bbalip.2019.04.001. Epub 2019 Apr 4.<\/p>\n

Obesity\u00a0and Cardioprotection.
<\/a>Femmin\u00f2 S, Pagliaro P, Penna C.
Curr Med Chem. 2020;27(2):230-239.\u00a0doi<\/g>: 10.2174\/0929867326666190325094453.<\/p>\n

Inhibition of\u00a0NLRP3\u00a0inflammasome activation by cell-permeable stapled peptides.
<\/a>Pal A, Neo K, Rajamani L, Ferrer FJ, Lane DP, Verma CS, Mortellaro A.
Sci Rep. 2019 Mar 20;9(1):4913. doi: 10.1038\/s41598-019-41211-3.<\/p>\n

Salvia\u00a0miltiorrhiza<\/g>\u00a0in diabetes: A review of its pharmacology, phytochemistry, and safety.
<\/a>Jia Q, Zhu R, Tian Y, Chen B, Li R, Li L, Wang L, Che Y, Zhao D, Mo F, Gao S, Zhang D.
Phytomedicine. 2019 May;58:152871.\u00a0doi<\/g>: 10.1016\/j.phymed.2019.152871. Epub 2019 Feb 18. Review.<\/p>\n

DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma.
<\/a>Jeong A, Imboden M, Ghantous A, Novoloaca A, Carsin AE, Kogevinas M, Schindler C, Lovison G, Herceg Z, Cuenin C, Vermeulen R, Jarvis D, Amaral AFS, Kronenberg F, Vineis P, Probst-Hensch N.
Int J Environ Res Public Health. 2019 Feb 19;16(4).\u00a0pii<\/g>: E600.\u00a0doi<\/g>: 10.3390\/ijerph16040600.<\/p>\n

Fish Oil Derived Omega 3 Fatty Acids Suppress Adipose\u00a0NLRP3\u00a0Inflammasome Signaling in Human\u00a0Obesity.
<\/a>Lee KR, Midgette Y, Shah R.
J Endocr Soc. 2018 Dec 24;3(3):504-515. doi: 10.1210\/js.2018-00220. eCollection 2019 Mar 1.<\/p>\n

Dietary modulation of energy\u00a0homoeostasis<\/g>\u00a0and metabolic-inflammation.
<\/a>Roche HM.
Proc Nutr Soc. 2019 Aug;78(3):313-318. doi: 10.1017\/S0029665118002872. Epub 2019 Feb 1.<\/p>\n

circARF3 Alleviates Mitophagy-Mediated Inflammation by Targeting miR-103\/TRAF3 in Mouse Adipose Tissue.
<\/a>Zhang Z, Zhang T, Feng R, Huang H, Xia T, Sun C.
Mol Ther Nucleic Acids. 2019 Mar 1;14:192-203.\u00a0doi<\/g>: 10.1016\/j.omtn.2018.11.014. Epub 2018 Dec 1.<\/p>\n

NLRP3\u00a0Inflammasome: A Possible Link Between\u00a0Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development.
<\/a>Ahechu P, Zozaya G, Mart\u00ed P, Hern\u00e1ndez-Lizo\u00e1in JL, Baixauli J, Unamuno X, Fr\u00fchbeck G, Catal\u00e1n V.
Front Immunol. 2018 Dec 11;9:2918.\u00a0doi<\/g>: 10.3389\/fimmu.2018.02918. eCollection 2018. Review.<\/p>\n

Loss of RIP3 initiates\u00a0annihilation<\/g>\u00a0of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress.
<\/a>Chenxu<\/g>\u00a0G, Minxuan X, Yuting Q, Tingting G,\u00a0Jing\u00a0F, Jinxiao L, Sujun W, Yongjie M, Deshuai L, Qiang L, Linfeng H, Xuyuan N, Mingxing W, Ping H, Jun T.
Free Radic Biol Med. 2019 Apr;134:23-41.\u00a0doi<\/g>: 10.1016\/j.freeradbiomed.2018.12.034. Epub 2018 Dec 30.<\/p>\n

SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain
<\/a>Tyagi A, Nguyen CU, Chong T, Michel CR, Fritz KS, Reisdorph N, Knaub L, Reusch JEB, Pugazhenthi S.
Sci Rep. 2018 Dec 3;8(1):17547. doi: 10.1038\/s41598-018-35890-7.<\/p>\n

Intermittent Fasting Improves Glucose Tolerance and Promotes Adipose Tissue Remodeling in Male Mice Fed a High-Fat Diet.
<\/a>Liu B, Page AJ, Hatzinikolas G, Chen M, Wittert GA, Heilbronn LK.
Endocrinology. 2019 Jan 1;160(1):169-180. doi: 10.1210\/en.2018-00701.<\/p>\n

Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein\/NLRP3Pathways.
<\/a>Zhou F, Zhang Y, Chen J, Hu Y, Xu Y.
Front Endocrinol (Lausanne). 2018 Oct 31;9:640. doi: 10.3389\/fendo.2018.00640. eCollection 2018.<\/p>\n

Purinergic 2X7 Receptor is Involved in the Podocyte Damage of\u00a0Obesity-Related Glomerulopathy via Activating Nucleotide-Binding and Oligomerization Domain-Like Receptor Protein 3 Inflammasome.
<\/a>Hou XX, Dong HR, Sun LJ, Yang M, Cheng H, Chen YP.
Chin Med J (Engl). 2018 Nov 20;131(22):2713-2725. doi: 10.4103\/0366-6999.245270.<\/p>\n

An Orally Available\u00a0NLRP3\u00a0Inflammasome Inhibitor Prevents Western Diet-Induced Cardiac Dysfunction in Mice.
<\/a>Carbone S, Mauro AG, Prestamburgo A, Halquist MS, Narayan P, Potere N, Mezzaroma E, Van Tassell BW, Abbate A, Toldo S.
J Cardiovasc Pharmacol. 2018 Dec;72(6):303-307.\u00a0doi<\/g>: 10.1097\/FJC.0000000000000628.<\/p>\n

The Small Molecule\u00a0NLRP3\u00a0Inflammasome Inhibitor MCC950 Does Not Alter Wound Healing in Obese Mice.
<\/a>Lee JS, Robertson AAB, Cooper MA, Khosrotehrani K.
Int J Mol Sci. 2018 Oct 23;19(11). pii: E3289. doi: 10.3390\/ijms19113289.<\/p>\n

Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation.
<\/a>Lyons CL, Roche HM.
Int J Mol Sci. 2018 Oct 9;19(10).\u00a0pii<\/g>: E3092.\u00a0doi<\/g>: 10.3390\/ijms19103092. Review.<\/p>\n

Palmitate aggravates proteinuria-induced cell death and inflammation via\u00a0CD36-inflammasome<\/g>\u00a0axis in the proximal tubular cells of obese mice.
<\/a>Li LC, Yang JL, Lee WC, Chen JB, Lee CT, Wang PW,\u00a0Vaghese<\/g>\u00a0Z, Chen WY.
Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1720-F1731.\u00a0doi<\/g>: 10.1152\/ajprenal.00536.2017. Epub 2018 Sep 19.<\/p>\n

Probiotics modify\u00a0body weight\u00a0together with anxiety states via pro-inflammatory factors in HFD-treated Syrian golden hamster.
<\/a>Avolio E, Fazzari G, Zizza M, De Lorenzo A, Di Renzo L, Al\u00f2 R, Facciolo RM, Canonaco M.
Behav Brain Res. 2019 Jan 1;356:390-399. doi: 10.1016\/j.bbr.2018.09.010. Epub 2018 Sep 14.<\/p>\n

Coptidis Rhizoma inhibits\u00a0NLRP3\u00a0inflammasome activation and alleviates renal damage in early\u00a0obesity-related glomerulopathy.
<\/a>Ren Y, Wang D, Lu F, Zou X, Xu L, Wang K, Huang W, Su H, Zhang C, Gao Y, Dong H.
Phytomedicine. 2018 Oct 1;49:52-65.\u00a0doi<\/g>: 10.1016\/j.phymed.2018.05.019. Epub 2018 Jun 7.<\/p>\n

PPAR\u03b3 Deficiency Suppresses the Release of IL-1\u03b2 and IL-1\u03b1 in Macrophages via a Type 1 IFN-Dependent Mechanism.
<\/a>Weber KJ, Sauer M, He L, Tycksen E, Kalugotla G, Razani B, Schilling JD.
J Immunol. 2018 Oct 1;201(7):2054-2069.\u00a0doi<\/g>: 10.4049\/jimmunol.1800224. Epub 2018 Aug 24.<\/p>\n

Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP\/NLRP3\u00a0Pathway.
<\/a>Zheng T, Yang X, Li W, Wang Q, Chen L, Wu D, Bian F, Xing S, Jin S.
Oxid Med Cell Longev. 2018 Jul 22;2018:8597897.\u00a0doi<\/g>: 10.1155\/2018\/8597897. eCollection 2018.<\/p>\n

The role of\u00a0NLRP3\u00a0inflammasome in stroke and central poststroke pain.
<\/a>Li SJ, Zhang YF, Ma SH, Yi Y, Yu HY, Pei L, Feng D.
Medicine (Baltimore). 2018 Aug;97(33):e11861. doi<\/g>: 10.1097\/MD.0000000000011861. Review.<\/p>\n

Erratum in:Inflammageing: chronic inflammation in\u00a0ageing<\/g>, cardiovascular disease, and\u00a0frailty.
<\/a>Ferrucci L, Fabbri E.
Nat Rev Cardiol. 2018 Sep;15(9):505-522. doi: 10.1038\/s41569-018-0064-2. Review.<\/p>\n

Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via\u00a0NLRP3<\/g>\u00a0inflammasome\/IL-1 signaling pathway.
<\/a>Zhu X, Zhang HW, Chen HN, Deng XJ, Tu YX, Jackson AO, Qing JN, Wang AP, Patel V, Yin K.
Acta Pharmacol Sin. 2019 Jan;40(1):46-54.\u00a0doi<\/g>: 10.1038\/s41401-018-0068-9. Epub 2018 Jul 12.<\/p>\n

Adiponectin inhibits\u00a0NLRP3\u00a0inflammasome by modulating the AMPK-ROS pathway.
<\/a>Wang F, Liu Y, Yang W, Yuan J, Mo Z.
Int J Clin Exp Pathol. 2018 Jul 1;11(7):3338-3347. eCollection 2018.<\/p>\n

Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease.
<\/a>Farrell GC, Haczeyni F, Chitturi S.
Adv Exp Med Biol. 2018;1061:19-44. doi: 10.1007\/978-981-10-8684-7_3. Review.<\/p>\n

Physical activity protects\u00a0NLRP3\u00a0inflammasome-associated coronary vascular dysfunction in obese mice.
<\/a>Lee J, Lee Y, LaVoy EC, Umetani M, Hong J, Park Y.
Physiol Rep. 2018 Jun;6(12):e13738. doi: 10.14814\/phy2.13738.<\/p>\n

Betaine in Inflammation: Mechanistic Aspects and Applications.
<\/a>Zhao G, He F, Wu C, Li P, Li N, Deng J, Zhu G, Ren W, Peng Y.
Front Immunol. 2018 May 24;9:1070.\u00a0doi<\/g>: 10.3389\/fimmu.2018.01070. eCollection 2018. Review.<\/p>\n

Saturated fatty acids,\u00a0obesity, and the nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in asthmatic patients.
<\/a>Wood LG, Li Q, Scott HA, Rutting S, Berthon BS, Gibson PG, Hansbro PM, Williams E, Horvat J, Simpson JL, Young P, Oliver BG, Baines KJ.
J Allergy Clin Immunol. 2019 Jan;143(1):305-315.\u00a0doi<\/g>: 10.1016\/j.jaci.2018.04.037. Epub 2018 May 30.<\/p>\n

Transient postnatal\u00a0over nutrition\u00a0induces long-term alterations in\u00a0cardiac<\/g>\u00a0NLRP3-inflammasome pathway.
<\/a>Siddeek B, Li N, Mauduit C, Chehade H, Rigal E, Tolsa JF, Armengaud JB, Yzydorczyk C, Benahmed M, Vergely C, Simeoni U.
Nutr Metab Cardiovasc Dis. 2018 Sep;28(9):944-951. doi: 10.1016\/j.numecd.2018.03.013. Epub 2018 Apr 14.<\/p>\n

Peripheral cannabinoid 1 receptor blockade mitigates adipose tissue inflammation via\u00a0NLRP3inflammasome in mouse models of\u00a0obesity.
<\/a>Han JH, Shin H, Rho JG, Kim JE, Son DH, Yoon J, Lee YJ, Park JH, Song BJ, Choi CS, Yoon SG, Kim IY, Lee EK, Seong JK, Kim KW, Kim W.
Diabetes Obes Metab. 2018 Sep;20(9):2179-2189.\u00a0doi<\/g>: 10.1111\/dom.13350. Epub 2018 Jun 5.<\/p>\n

NLRP3\u00a0Inflammasome Activation Regulates Aged RBC Clearance.
<\/a>Qin L, Fengyong Z, Jiamin Z, Qixiu Y, Geming L, Rongwei X, Ziyan Z.
Inflammation. 2018 Aug;41(4):1361-1371. doi: 10.1007\/s10753-018-0784-9.<\/p>\n

Self-assembled hyaluronic acid nanoparticles: Implications as\u00a0a nanomedicine<\/g>\u00a0for\u00a0treatment<\/g>\u00a0of type 2 diabetes.
<\/a>Rho JG, Han HS, Han JH, Lee H, Nguyen VQ, Lee WH, Kwon S, Heo S, Yoon J, Shin HH, Lee EY, Kang H, Yang S, Lee EK, Park JH, Kim W.
J Control Release. 2018 Jun 10;279:89-98. doi: 10.1016\/j.jconrel.2018.04.006. Epub 2018 Apr 9.<\/p>\n

Myogenic oxidative imbalance interferes with antral motility in obese subjects.
<\/a>Scirocco A, Pallotta L, Rengo M, Ignazzi A, Carabotti M, Cicenia A, Vona R, Chirletti P, Maselli MA, Donghia R, Coluzzi M, Matarrese P, Silecchia G, Severi C.
Dig Liver Dis. 2018 Aug;50(8):820-827.\u00a0doi<\/g>: 10.1016\/j.dld.2018.03.005. Epub 2018 Mar 14.<\/p>\n

Role of dietary \u03b1- and \u03b3-tocopherol from Rosa\u00a0mosqueta<\/g>\u00a0oil in the prevention of alterations induced by\u00a0high-fat<\/g>\u00a0diet in a murine model.
<\/a>Tapia G, Silva D, Romero N, Pettinelli P, Dossi CG, de Miguel M, Gonz\u00e1lez-Ma\u00f1\u00e1n D.
Nutrition. 2018 Sep;53:1-8. doi: 10.1016\/j.nut.2018.01.012. Epub 2018 Apr 3.<\/p>\n

Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation.
<\/a>Kotzbeck P, Giordano A, Mondini E, Murano I, Severi I, Venema W, Cecchini MP, Kershaw EE, Barbatelli G, Haemmerle G, Zechner R, Cinti S.
J Lipid Res. 2018 May;59(5):784-794.\u00a0doi<\/g>: 10.1194\/jlr.M079665. Epub 2018 Mar 29.<\/p>\n

Cardiovascular diseases,\u00a0NLRP3\u00a0inflammasome, and western dietary patterns.
<\/a>Pavillard LE, Mar\u00edn-Aguilar F, Bullon P, Cordero MD.
Pharmacol Res. 2018 May;131:44-50.\u00a0doi<\/g>: 10.1016\/j.phrs.2018.03.018. Epub 2018 Mar 26. Review.<\/p>\n

Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study.
<\/a>Mohamed IN, Sarhan NR, Eladl MA, El-Remessy AB, El-Sherbiny M.
Acta Histochem. 2018 Apr;120(3):242-254. doi: 10.1016\/j.acthis.2018.02.006. Epub 2018 Feb 23.<\/p>\n

Metabolic\/inflammatory\/vascular comorbidity in psychiatric disorders; soluble epoxide hydrolase (sEH) as a possible new target.
<\/a>Swardfager W, Hennebelle M, Yu D, Hammock BD, Levitt AJ, Hashimoto K, Taha AY.
Neurosci Biobehav Rev. 2018 Apr;87:56-66. doi: 10.1016\/j.neubiorev.2018.01.010. Epub 2018 Feb 2. Review.<\/p>\n

Role of microbiota-derived lipopolysaccharide in adipose tissue inflammation, adipocyte size\u00a0and<\/g>\u00a0pyroptosis during\u00a0obesity.
<\/a>Hersoug LG, M\u00f8ller P, Loft S.
Nutr Res Rev. 2018 Dec;31(2):153-163.\u00a0doi<\/g>: 10.1017\/S0954422417000269. Epub 2018 Jan 24. Review.<\/p>\n

Obesity\u00a0or Overweight, a Chronic Inflammatory Status in Male Reproductive System, Leads to Mice and Human Subfertility.
<\/a>Fan W, Xu Y, Liu Y, Zhang Z, Lu L, Ding Z.
Front Physiol. 2018 Jan 4;8:1117.\u00a0doi<\/g>: 10.3389\/fphys.2017.01117. eCollection 2017.<\/p>\n

Calcium-sensing receptor activates the\u00a0NLRP3\u00a0inflammasome in LS14 preadipocytes mediated by ERK1\/2 signaling.
<\/a>D’Espessailles A, Mora YA, Fuentes C, Cifuentes M.
J Cell Physiol. 2018 Aug;233(8):6232-6240.\u00a0doi<\/g>: 10.1002\/jcp.26490. Epub 2018 Mar 9.<\/p>\n

Inhibitory Effects of Toll-Like Receptor 4,\u00a0NLRP3\u00a0Inflammasome, and Interleukin-1\u03b2 on White Adipocyte Browning.
<\/a>Okla M, Zaher W, Alfayez M, Chung S.
Inflammation. 2018 Mar;41(2):626-642. doi: 10.1007\/s10753-017-0718-y.<\/p>\n

Lithium + Colchicine: A Potential Strategy to Reduce Pro-inflammatory Effects of Lithium Treatment.
<\/a>Mooney JJ, Brady RO.
J Clin Psychopharmacol. 2018 Feb;38(1):80-85.\u00a0doi<\/g>: 10.1097\/JCP.0000000000000830. Review.<\/p>\n

Author Correction: Lack of\u00a0NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD.
<\/a>Pierantonelli I, Rychlicki C, Agostinelli L, Giordano DM, Gaggini M, Fraumene C, Saponaro C, Manghina V, Sartini L, Mingarelli E, Pinto C, Buzzigoli E, Trozzi L, Giordano A, Marzioni M, De Minicis S, Uzzau S, Cinti S, Gastaldelli A, Svegliati-Baroni G.
Sci Rep. 2017 Dec 11;7(1):17568. doi: 10.1038\/s41598-017-17187-3.<\/p>\n

Red raspberries suppress\u00a0NLRP3\u00a0inflammasome and attenuate metabolic abnormalities in diet-induced obese mice.
<\/a>Zhu MJ, Kang Y, Xue Y, Liang X, Garc\u00eda MPG, Rodgers D, Kagel DR, Du M.
J Nutr Biochem. 2018 Mar;53:96-103. doi: 10.1016\/j.jnutbio.2017.10.012. Epub 2017 Nov 2.<\/p>\n

Vitamin D3 levels and\u00a0NLRP3\u00a0expression in murine models of obese asthma: association with asthma outcomes.
<\/a>Zhang JH, Chen YP, Yang X, Li CQ.
Braz J Med Biol Res. 2017 Nov 13;51(1):e6841. doi: 10.1590\/1414-431X20176841.<\/span><\/p>\n

AMP-Activated Protein Kinase Regulation of the\u00a0NLRP3\u00a0Inflammasome during Aging.
<\/a>Cordero MD, Williams MR, Ryffel B.
<\/span>Trends Endocrinol Metab. 2018 Jan;29(1):8-17. doi: 10.1016\/j.tem.2017.10.009. Epub 2017 Nov 14. Review.<\/p>\n

Diet-induced\u00a0obesity\u00a0leads to pro-inflammatory alterations to the vitreous\u00a0humour<\/g>\u00a0of the eye in a rat model.
<\/a>Collins KH, Herzog W, Reimer RA, Reno CR, Heard BJ, Hart DA.
Inflamm Res. 2018 Feb;67(2):139-146. doi: 10.1007\/s00011-017-1102-y. Epub 2017 Oct 26.<\/p>\n

Macrophage alternative activation confers protection against lipotoxicity-induced cell death.
<\/a>Dai L, Bhargava P, Stanya KJ, Alexander RK, Liou YH, Jacobi D, Knudsen NH, Hyde A, Gangl MR, Liu S, Lee CH.
Mol Metab. 2017 Oct;6(10):1186-1197. doi: 10.1016\/j.molmet.2017.08.001. Epub 2017 Aug 7.<\/p>\n

Lipid environment induces ER stress, TXNIP expression\u00a0and<\/g>\u00a0inflammation in immune cells of individuals with type 2 diabetes.
<\/a>Szpigel A, Hainault I, Carlier A, Venteclef N, Batto AF, Hajduch E, Bernard C, Ktorza A, Gautier JF, Ferr\u00e9 P, Bourron O, Foufelle F.
Diabetologia. 2018 Feb;61(2):399-412. doi: 10.1007\/s00125-017-4462-5. Epub 2017 Oct 7.<\/p>\n

Weighted Gene Co-Expression Network Analysis Identifies\u00a0Gender Specific<\/g>\u00a0Modules and Hub Genes Related to Metabolism and Inflammation in Response to an Acute Lipid Challenge.
<\/a>Fatima A, Connaughton RM, Weiser A, Murphy AM,\u00a0O’Grada<\/g>\u00a0C, Ryan M, Brennan L, O’Gaora P, Roche HM.
Mol Nutr Food Res. 2018 Jan;62(2).\u00a0<\/span>doi<\/g>: 10.1002\/mnfr.201700388. Epub 2017 Dec 11.<\/span><\/p>\n

Lack of\u00a0NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD.
<\/a>Pierantonelli I, Rychlicki C, Agostinelli L, Giordano DM, Gaggini M, Fraumene C, Saponaro C, Manghina V, Sartini L, Mingarelli E, Pinto C, Buzzigoli E, Trozzi L, Giordano A, Marzioni M, Minicis S, Uzzau S, Cinti S, Gastaldelli A, Svegliati-Baroni G.
Sci Rep. 2017 Sep 22;7(1):12200. doi: 10.1038\/s41598-017-11744-6.<\/p>\n

Erratum in:\u00a0<\/span>Sci Rep. 2017 Dec 11;7(1):17568<\/a>.<\/span>Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy.
<\/a>Garibotto G, Carta A, Picciotto D, Viazzi F, Verzola D.
<\/span>J Nephrol. 2017 Dec;30(6):719-727.\u00a0<\/span>doi<\/g>: 10.1007\/s40620-017-0432-8. Epub 2017 Sep 20. Review.<\/span><\/p>\n

The NLPR3 inflammasome and\u00a0obesity-related kidney disease.
<\/a>Ke B, Shen W, Fang X, Wu Q.
J Cell Mol Med. 2018 Jan;22(1):16-24.\u00a0<\/span>doi<\/g>: 10.1111\/jcmm.13333. Epub 2017 Aug 31. Review.<\/span><\/p>\n

Eplerenone prevented\u00a0obesity-induced inflammasome activation and glucose intolerance.
<\/a>Wada T, Ishikawa A, Watanabe E, Nakamura Y, Aruga Y, Hasegawa H, Onogi Y, Honda H, Nagai Y, Takatsu K, Ishii Y, Sasahara M, Koya D, Tsuneki H, Sasaoka T.
J Endocrinol. 2017 Dec;235(3):179-191.\u00a0doi<\/g>: 10.1530\/JOE-17-0351. Epub 2017 Aug 30.<\/p>\n

Fatty Acids and\u00a0NLRP3\u00a0Inflammasome-Mediated Inflammation in Metabolic Tissues.
<\/a>Ralston JC, Lyons CL, Kennedy EB, Kirwan AM, Roche HM.
<\/span>Annu Rev Nutr. 2017 Aug 21;37:77-102. doi: 10.1146\/annurev-nutr-071816-064836. Review.<\/span><\/p>\n

The Inhibitory Effects of Purple Sweet Potato Color on Hepatic Inflammation Is Associated with Restoration of NAD\u207a Levels and Attenuation of\u00a0NLRP3\u00a0Inflammasome Activation in High-Fat-Diet-Treated Mice.
<\/a>Wang X, Zhang ZF, Zheng GH, Wang AM, Sun CH, Qin SP, Zhuang J, Lu J, Ma DF, Zheng YL.
<\/span>Molecules. 2017 Aug 8;22(8). pii: E1315. doi: 10.3390\/molecules22081315.<\/span><\/p>\n

Implication<\/g>\u00a0of REDD1 in the activation of inflammatory pathways.
<\/a>Pastor F, Dumas K, Barth\u00e9l\u00e9my MA, Regazzetti C, Druelle N, Peraldi P, Cormont M, Tanti JF, Giorgetti-Peraldi S.
<\/span>Sci Rep. 2017 Aug 1;7(1):7023. doi: 10.1038\/s41598-017-07182-z.<\/span><\/p>\n

Current role of the\u00a0NLRP3\u00a0inflammasome on\u00a0obesity\u00a0and insulin resistance: A systematic review.
<\/a>Rheinheimer J, de Souza BM, Cardoso NS, Bauer AC, Crispim D.
<\/span>Metabolism. 2017 Sep;74:1-9. doi: 10.1016\/j.metabol.2017.06.002. Epub 2017 Jun 11. Review.<\/span><\/p>\n

T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders.
<\/a>Rani J, Mittal I, Pramanik A, Singh N, Dube N, Sharma S, Puniya BL, Raghunandanan MV, Mobeen A, Ramachandran S.
<\/span>Sci Rep. 2017 Jul 31;7(1):6892. doi: 10.1038\/s41598-017-07238-0.<\/span><\/p>\n

Nutritional modulation of metabolic inflammation.
<\/a>Kirwan AM, Lenighan YM, O’Reilly ME, McGillicuddy FC, Roche HM.
<\/span>Biochem Soc Trans. 2017 Aug 15;45(4):979-985.\u00a0<\/span>doi<\/g>: 10.1042\/BST20160465. Epub 2017 Jul 14. Review.<\/span><\/p>\n

Can Serum Uric Acid Lowering Therapy Contribute to the Prevention or Treatment of Nonalcoholic Fatty Liver Disease?
<\/a>Paschos P, Athyros VG, Tsimperidis A, Katsoula A, Grammatikos N, Giouleme O.
<\/span>Curr Vasc Pharmacol. 2018;16(3):269-275.\u00a0<\/span>doi<\/g>: 10.2174\/1570161115666170621082237. Review.<\/span><\/p>\n

Lipocalin-2 induces\u00a0NLRP3\u00a0inflammasome activation via HMGB1 induced TLR4 signaling in\u00a0heart<\/g>\u00a0tissue of mice under pressure overload challenge.
<\/a>Song E, Jahng JW, Chong LP, Sung HK, Han M, Luo C, Wu D, Boo S, Hinz B, Cooper MA, Robertson AA, Berger T, Mak TW, George I, Schulze PC, Wang Y, Xu A, Sweeney G.
<\/span>Am J Transl Res. 2017 Jun 15;9(6):2723-2735. eCollection 2017.<\/span><\/p>\n

Deletion of TXNIP Mitigates High-Fat Diet-Impaired Angiogenesis and Prevents Inflammation in a Mouse Model of Critical Limb Ischemia.
<\/a>Elshaer SL, Mohamed IN,\u00a0<\/span>Coucha<\/g>\u00a0M, Altantawi S, Eldahshan W, Bartasi ML, Shanab AY, Lorys R, El-Remessy AB.
<\/span>Antioxidants (Basel). 2017 Jun 29;6(3). pii: E47. doi: 10.3390\/antiox6030047.<\/span><\/p>\n

The critical role of macrophages in the pathogenesis of hidradenitis\u00a0suppurativa<\/g>.
<\/a>Shah A, Alhusayen R, Amini-Nik S.
<\/span>Inflamm Res. 2017 Nov;66(11):931-945.\u00a0<\/span>doi<\/g>: 10.1007\/s00011-017-1074-y. Epub 2017 Jun 27. Review.<\/span><\/p>\n

Gain-of-function SNPs in\u00a0NLRP3\u00a0and IL1B genes confer protection against\u00a0obesity\u00a0and T2D: undiscovered role of inflammasome genetics in metabolic homeostasis?
<\/a>de Moraes Rodrigues J, Souza de Lima D, Leal VNC, Bosco AA, Sandrim V, Pontillo A.
<\/span>Endocrine. 2018 May;60(2):368-371.\u00a0<\/span>doi<\/g>: 10.1007\/s12020-017-1343-0. Epub 2017 Jun 20. No abstract available.<\/span><\/p>\n

Metabolic injury-induced\u00a0NLRP3\u00a0inflammasome activation dampens phospholipid degradation.
<\/a>Rampanelli E, Ors\u00f3 E, Ochodnicky P, Liebisch G, Bakker PJ, Claessen N, Butter LM, van den Bergh Weerman MA, Florquin S, Schmitz G, Leemans JC.
<\/span>Sci Rep. 2017 Jun 6;7(1):2861. doi: 10.1038\/s41598-017-01994-9.<\/span><\/p>\n

Endothelial Dysfunction in\u00a0Obesity.
<\/a>Engin A.
<\/span>Adv Exp Med Biol. 2017;960:345-379. doi: 10.1007\/978-3-319-48382-5_15. Review.
<\/span>Engin AB.
<\/span>Adv Exp Med Biol. 2017;960:327-343. doi: 10.1007\/978-3-319-48382-5_14. Review.<\/span><\/p>\n

The Pathogenesis of\u00a0Obesity-Associated Adipose Tissue Inflammation.
<\/a>Engin A.
<\/span>Adv Exp Med Biol. 2017;960:221-245. doi: 10.1007\/978-3-319-48382-5_9. Review.<\/span><\/p>\n

<\/span>Fat Cell and Fatty Acid Turnover in\u00a0Obesity.
<\/a>Engin A.
<\/span>Adv Exp Med Biol. 2017;960:135-160. doi: 10.1007\/978-3-319-48382-5_6. Review.<\/span><\/p>\n

Advanced glycation end products regulate interleukin-1\u03b2 production in\u00a0human<\/g>\u00a0placenta.
<\/a>Seno K, Sase S, Ozeki A, Takahashi H, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T, Shirasuna K.
<\/span>J Reprod Dev. 2017 Aug 19;63(4):401-408.\u00a0<\/span>doi<\/g>: 10.1262\/jrd.2017-032. Epub 2017 May 18.<\/span><\/p>\n

\u00a0Ameliorative Effect of Ecklonia cava Polyphenol\u00a0Extract<\/g>\u00a0on Renal Inflammation Associated with Aberrant Energy Metabolism and Oxidative Stress in High Fat Diet-Induced Obese Mice.
<\/a>Eo H, Park JE, Jeon YJ, Lim Y.
<\/span>J Agric Food Chem. 2017 May 17;65(19):3811-3818. doi: 10.1021\/acs.jafc.7b00357. Epub 2017 May 5.<\/span><\/p>\n

Foxo3a-dependent Bim transcription protects mice from a\u00a0high fat<\/g>\u00a0diet via inhibition of activation of the\u00a0NLRP3\u00a0inflammasome by facilitating autophagy flux in Kupffer cells.
<\/a>Liu Y, Zhang W, Wu X, Gong J.
<\/span>Oncotarget. 2017 May 23;8(21):34258-34267. doi: 10.18632\/oncotarget.15946.<\/span><\/p>\n

Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of\u00a0NLRP3\u00a0inflammasome activation and NF-\u03baB signaling.
<\/a>Yuan C, Liu C, Wang T, He Y, Zhou Z, Dun Y, Zhao H, Ren D, Wang J, Zhang C, Yuan D.
<\/span>Oncotarget. 2017 May 9;8(19):31023-31040. doi: 10.18632\/oncotarget.16052.<\/span><\/p>\n

Metaflammation: Tissue-Specific Alterations of the\u00a0NLRP3\u00a0Inflammasome Platform in Metabolic Syndrome.
<\/a>Mastrocola R, Aragno M, Alloatti G, Collino M, Penna C, Pagliaro P.
<\/span>Curr Med Chem. 2018;25(11):1294-1310.\u00a0<\/span>doi<\/g>: 10.2174\/0929867324666170407123522. Review.<\/span><\/p>\n

Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-\u03baB\/GSDMD signal in mice adipose tissue.
<\/a>Liu Z, Gan L, Xu Y, Luo D, Ren Q, Wu S, Sun C.
<\/span>J Pineal Res. 2017 Aug;63(1).\u00a0<\/span>doi<\/g>: 10.1111\/jpi.12414. Epub 2017 May 22.<\/span><\/p>\n

Berberine inhibits palmitate-induced\u00a0NLRP3\u00a0inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement.
<\/a>Zhou H, Feng L, Xu F, Sun Y, Ma Y, Zhang X, Liu H, Xu G, Wu X, Shen Y, Sun Y, Wu X, Xu Q.
<\/span>Biomed Pharmacother. 2017 May;89:864-874. doi: 10.1016\/j.biopha.2017.03.003. Epub 2017 Mar 6.<\/span><\/p>\n

<\/span>High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress.
<\/a>Coucha<\/g>\u00a0M, Mohamed IN, Elshaer SL, Mbata O, Bartasis ML, El-Remessy AB.
World J Diabetes. 2017 Feb 15;8(2):56-65. doi: 10.4239\/wjd.v8.i2.56.<\/p>\n

Advanced glycation end products regulate anabolic and catabolic activities via\u00a0NLRP3-inflammasome activation in human nucleus pulposus cells.
<\/a>Song Y, Wang Y, Zhang Y, Geng W, Liu W, Gao Y, Li S, Wang K, Wu X, Kang L, Yang C.
<\/span>J Cell Mol Med. 2017 Jul;21(7):1373-1387.\u00a0<\/span>doi<\/g>: 10.1111\/jcmm.13067. Epub 2017 Feb 22.<\/span><\/p>\n

Inflammasome Priming in Sterile Inflammatory Disease.
<\/a>Patel MN, Carroll RG, Galv\u00e1n-Pe\u00f1a S, Mills EL, Olden R, Triantafilou M, Wolf AI, Bryant CE, Triantafilou K, Masters SL.
<\/span>Trends Mol Med. 2017 Feb;23(2):165-180.\u00a0<\/span>doi<\/g>: 10.1016\/j.molmed.2016.12.007. Epub 2017 Jan 18. Review.<\/span><\/p>\n

Postprandial macrophage-derived IL-1\u03b2 stimulates insulin, and both synergistically promote glucose disposal and inflammation.
<\/a>Dror E, Dalmas E, Meier DT, Wueest S, Th\u00e9venet J, Thienel C, Timper K, Nordmann TM, Traub S, Schulze F, Item F, Vallois D, Pattou F, Kerr-Conte J, Lavallard V, Berney T, Thorens B, Konrad D, B\u00f6ni-Schnetzler M, Donath MY.
<\/span>Nat Immunol. 2017 Mar;18(3):283-292.\u00a0<\/span>doi<\/g>: 10.1038\/ni.3659. Epub 2017 Jan 16.<\/span><\/p>\n

Early PQQ supplementation has persistent long-term protective effects on\u00a0developmental<\/g>\u00a0programming of hepatic lipotoxicity and inflammation in obese mice.
<\/a>Jonscher KR, Stewart MS, Alfonso-Garcia A, DeFelice BC, Wang XX, Luo Y, Levi M, Heerwagen MJ, Janssen RC, de la Houssaye BA, Wiitala E, Florey G, Jonscher RL, Potma EO, Fiehn O, Friedman JE.
<\/span>FASEB J. 2017 Apr;31(4):1434-1448. doi: 10.1096\/fj.201600906R. Epub 2016 Dec 22.<\/span><\/p>\n

The role of caloric load and mitochondrial homeostasis in the regulation of the\u00a0NLRP3\u00a0inflammasome.
<\/a>Traba J, Sack MN.
<\/span>Cell Mol Life Sci. 2017 May;74(10):1777-1791.\u00a0<\/span>doi<\/g>: 10.1007\/s00018-016-2431-7. Epub 2016 Dec 10. Review.<\/span><\/p>\n

Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via Adenosine.
<\/a>Birnbaum Y, Birnbaum GD, Birnbaum I, Nylander S, Ye Y.
<\/span>Cardiovasc Drugs Ther. 2016 Dec;30(6):539-550.<\/span><\/p>\n

FABP4\/aP2 Regulates Macrophage Redox Signaling and Inflammasome Activation via Control of UCP2.
<\/a>Steen KA, Xu H, Bernlohr DA.
<\/span>Mol Cell Biol. 2017 Jan 4;37(2). pii: e00282-16. doi: 10.1128\/MCB.00282-16. Print 2017 Jan 15.<\/span><\/p>\n

Mitochondria as a centrally positioned hub in the innate immune response.
<\/a>Sandhir R, Halder A, Sunkaria A.
<\/span>Biochim Biophys Acta Mol Basis Dis. 2017 May;1863(5):1090-1097.\u00a0<\/span>doi<\/g>: 10.1016\/j.bbadis.2016.10.020. Epub 2016 Oct 26. Review.<\/span><\/p>\n

<\/span>Role of dietary fatty acids in liver injury caused by vinyl chloride metabolites in mice.
<\/a>Anders LC, Yeo H, Kaelin BR, Lang AL, Bushau AM, Douglas AN, Cave M, Arteel GE, McClain CJ, Beier JI.
<\/span>Toxicol Appl Pharmacol. 2016 Nov 15;311:34-41. doi: 10.1016\/j.taap.2016.09.026. Epub 2016 Sep 28.<\/span><\/p>\n

Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated\u00a0Nlrp3\u00a0inflammasome activation.
<\/a>Wang L, Chen Y, Li X, Zhang Y, Gulbins E, Zhang Y.
<\/span>Oncotarget. 2016 Nov 8;7(45):73229-73241. doi: 10.18632\/oncotarget.12302.<\/span><\/p>\n

Nebivolol Ameliorates Cardiac\u00a0NLRP3\u00a0Inflammasome Activation in a Juvenile-Adolescent Animal Model of Diet-Induced\u00a0Obesity.
<\/a>Xie Q, Wei T, Huang C, Liu P, Sun M, Shen W, Gao P.
<\/span>Sci Rep. 2016 Sep 30;6:34326. doi: 10.1038\/srep34326.<\/span><\/p>\n

Effect of Roux-en-Y Gastric Bypass on the\u00a0NLRP3\u00a0Inflammasome in Pancreatic Islets from Zucker Diabetic Fatty Rats.
<\/a>Mocanu AO, Mulya A, Huang H, Dan O, Schauer PR, Dinischiotu A, Brethauer SA, Kirwan JP.
Obes Surg. 2016 Dec;26(12):3076-3081.<\/span><\/p>\n

Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the\u00a0NLRP3\u00a0Inflammasome, and the Danger Signal HMGB1.
<\/a>Sobesky JL, D’Angelo HM, Weber MD, Anderson ND, Frank MG, Watkins LR, Maier SF, Barrientos RM.
<\/span>eNeuro. 2016 Aug 30;3(4).\u00a0<\/span>pii<\/g>: ENEURO.0113-16.2016.\u00a0<\/span>doi<\/g>: 10.1523\/ENEURO.0113-16.2016. eCollection 2016 Jul-Aug.<\/span><\/p>\n

Loss of\u00a0Nlrp3\u00a0Does Not Protect Mice from Western Diet-Induced Adipose Tissue Inflammation and Glucose Intolerance.
<\/a>Ringling RE, Gastecki ML, Woodford ML, Lum-Naihe KJ, Grant RW, Pulakat L, Vieira-Potter VJ, Padilla J.
<\/span>PLoS One. 2016 Sep 1;11(9):e0161939. doi: 10.1371\/journal.pone.0161939. eCollection 2016.<\/span><\/p>\n

Apolipoprotein A-I gene transfer exerts immunomodulatory effects and reduces vascular inflammation and fibrosis in ob\/ob mice.
<\/a>Spillmann F, De Geest B, Muthuramu I, Amin R, Miteva K, Pieske B, Tsch\u00f6pe C, Van Linthout S.
<\/span>J Inflamm (Lond). 2016 Aug 2;13:25. doi: 10.1186\/s12950-016-0131-6. eCollection 2016.<\/span><\/p>\n

Inflammasomes link\u00a0vascular<\/g>\u00a0disease with neuroinflammation and brain disorders.
<\/a>L\u00e9n\u00e1rt N, Brough D, D\u00e9nes \u00c1.
<\/span>J Cereb Blood Flow Metab. 2016 Oct;36(10):1668-1685. Epub 2016 Aug 2. Review.<\/span><\/p>\n

Dietary<\/g>\u00a0fatty acid composition is sensed by the\u00a0NLRP3\u00a0inflammasome: omega-3 fatty acid (DHA) prevents\u00a0NLRP3\u00a0activation in human macrophages.
<\/a>Mart\u00ednez-Micaelo N, Gonz\u00e1lez-Abu\u00edn N, Pinent M, Ard\u00e9vol A, Blay M.
Food Funct. 2016 Aug 10;7(8):3480-7.\u00a0doi<\/g>: 10.1039\/c6fo00477f. Epub 2016 Jul 13.<\/p>\n

A casein hydrolysate protects mice against\u00a0high fat<\/g>\u00a0diet induced<\/g>\u00a0hyperglycemia by attenuating\u00a0NLRP3inflammasome-mediated inflammation and improving insulin signaling.
<\/a>Healy NP, Kirwan AM, McArdle MA, Holohan K, Nongonierma AB, Keane D, Kelly S, Celkova L, Lyons CL, McGillicuddy FC, Finucane OM, Murray BA, Kelly PM, Brennan L, FitzGerald RJ, Roche HM.
<\/span>Mol Nutr Food Res. 2016 Nov;60(11):2421-2432.\u00a0<\/span>doi<\/g>: 10.1002\/mnfr.201501054. Epub 2016 Sep 8.<\/span><\/p>\n

n-3 Fatty acids modulate the mRNA expression of the\u00a0Nlrp3\u00a0inflammasome and\u00a0Mtor<\/g>\u00a0in the liver of rats fed with high-fat or high-fat\/fructose diets.
<\/a>Garay-Lugo N, Dom\u00ednguez-Lopez A, Miliar Garc\u00eda A, Aguilar Barrera E, G\u00f3mez L\u00f3pez M, G\u00f3mez Alcal\u00e1 A, Mart\u00ednez Godinez Mde L, Lara-Padilla E.
<\/span>Immunopharmacol Immunotoxicol. 2016 Oct;38(5):353-63.\u00a0<\/span>doi<\/g>: 10.1080\/08923973.2016.1208221.<\/span><\/p>\n

Obesity\u00a0and Type 2 Diabetes Alters the Immune Properties of Human\u00a0Adipose Derived<\/g>\u00a0Stem Cells.
<\/a>Serena C, Keiran N, Ceperuelo-Mallafre V, Ejarque M, Fradera R, Roche K, Nu\u00f1ez-Roa C, Vendrell J, Fern\u00e1ndez-Veledo S.
<\/span>Stem Cells. 2016 Oct;34(10):2559-2573.\u00a0<\/span>doi<\/g>: 10.1002\/stem.2429. Epub 2016 Jul 4.<\/span><\/p>\n

New insights into salvianolic acid A action: Regulation of the TXNIP\/NLRP3\u00a0and TXNIP\/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
<\/a>Ding C, Zhao Y, Shi X, Zhang N, Zu G, Li Z, Zhou J, Gao D, Lv L, Tian X, Yao J.
<\/span>Sci Rep. 2016 Jun 27;6:28734. doi: 10.1038\/srep28734.<\/span><\/p>\n

Phosphodiesterase 3B (PDE3B) regulates\u00a0NLRP3\u00a0inflammasome in adipose tissue.
<\/a>Ahmad F, Chung YW, Tang Y, Hockman SC, Liu S, Khan Y, Huo K, Billings E, Amar MJ, Remaley AT, Manganiello VC.
<\/span>Sci Rep. 2016 Jun 20;6:28056. doi: 10.1038\/srep28056.<\/span><\/p>\n

Palmitic acid induces interleukin-1\u03b2 secretion via\u00a0NLRP3\u00a0inflammasomes and inflammatory responses through ROS production in human placental cells.
<\/a>Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T.
<\/span>J Reprod Immunol. 2016 Aug;116:104-12.\u00a0<\/span>doi<\/g>: 10.1016\/j.jri.2016.06.001. Epub 2016 Jun 6.<\/span><\/p>\n

Colchicine to decrease\u00a0NLRP3-activated inflammation and improve\u00a0obesity-related metabolic dysregulation.
<\/a>Demidowich AP, Davis AI, Dedhia N, Yanovski JA.
<\/span>Med Hypotheses. 2016 Jul;92:67-73.\u00a0<\/span>doi<\/g>: 10.1016\/j.mehy.2016.04.039. Epub 2016 Apr 25.<\/span><\/p>\n

Macrophages Play a Key Role in the\u00a0Obesity-Induced Periodontal Innate Immune Dysfunction via Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Pathway.
<\/a>Huang X, Yu T, Ma C, Wang Y, Xie B, Xuan D, Zhang J.
<\/span>J Periodontol. 2016 Oct;87(10):1195-205. doi: 10.1902\/jop.2016.160102. Epub 2016 May 23. Erratum in:\u00a0<\/span>J Periodontol. 2017 Jun;88(6):614<\/a>.<\/span><\/p>\n

Fish-oil-derived n-3 polyunsaturated fatty acids reduce\u00a0NLRP3\u00a0inflammasome activity and\u00a0obesity-related inflammatory cross-talk between adipocytes and CD11b(+) macrophages.
<\/a>De Boer AA, Monk JM, Liddle DM, Hutchinson AL, Power KA, Ma DW, Robinson LE.
<\/span>J Nutr Biochem. 2016 Aug;34:61-72. doi: 10.1016\/j.jnutbio.2016.04.004. Epub 2016 Apr 29.<\/span><\/p>\n

The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise.
<\/a>Cai M, Wang H, Li JJ, Zhang YL, Xin L, Li F, Lou SJ.
<\/span>Brain Behav Immun. 2016 Oct;57:347-359. doi: 10.1016\/j.bbi.2016.05.010. Epub 2016 May 14.<\/span><\/p>\n

Depot- and gender-specific expression of\u00a0NLRP3\u00a0inflammasome and toll-like receptors in adipose tissue of cancer patients.
<\/a>Shimabukuro M, Sato H, Izaki H, Fukuda D, Uematsu E, Hirata Y, Yagi S, Soeki T, Sakaue H, Kanayama HO, Masuzaki H, Sata M.
<\/span>Biofactors. 2016 Jul 8;42(4):397-406.\u00a0<\/span>doi<\/g>: 10.1002\/biof.1287. Epub 2016 Apr 18.<\/span><\/p>\n

Glutamine Modulates Macrophage Lipotoxicity.
<\/a>He L, Weber KJ, Schilling JD.
<\/span>Nutrients. 2016 Apr 12;8(4):215. doi: 10.3390\/nu8040215.<\/span><\/p>\n

TNF-\u03b1 Induces Caspase-1 Activation Independently of Simultaneously Induced\u00a0NLRP3\u00a0in 3T3-L1\u00a0Cells.
<\/a>Furuoka M, Ozaki K, Sadatomi D, Mamiya S, Yonezawa T, Tanimura S, Takeda K.
<\/span>J Cell Physiol. 2016 Dec;231(12):2761-7.\u00a0<\/span>doi<\/g>: 10.1002\/jcp.25385. Epub 2016 Mar 30.<\/span><\/p>\n

Instigation of\u00a0NLRP3\u00a0inflammasome activation and glomerular injury in mice on the\u00a0high fat<\/g>\u00a0diet: role of acid sphingomyelinase gene.
<\/a>Boini KM, Xia M, Koka S, Gehr TW, Li PL.
<\/span>Oncotarget. 2016 Apr 5;7(14):19031-44. doi: 10.18632\/oncotarget.8023.<\/span>\u00a0<\/span><\/p>\n

Crosstalk between the heart and peripheral organs in heart failure.
<\/a>Jahng JW, Song E, Sweeney G.
<\/span>Exp Mol Med. 2016 Mar 11;48:e217.\u00a0<\/span>doi<\/g>: 10.1038\/emm.2016.20. Review.<\/span><\/p>\n

Regulation of the clock gene expression in human adipose tissue by weight loss.
<\/a>Pivovarova O, G\u00f6gebakan \u00d6, Sucher S, Groth J, Murahovschi V, Kessler K, Osterhoff M, Rudovich N, Kramer A, Pfeiffer AF.
<\/span>Int J Obes (Lond). 2016 Jun;40(6):899-906.\u00a0<\/span>doi<\/g>: 10.1038\/ijo.2016.34. Epub 2016 Feb 23.<\/span><\/p>\n

Autophagy and\u00a0Obesity-Related Lung Disease
<\/a>Pabon MA, Ma KC, Choi AM.
<\/span>Am J Respir Cell Mol Biol. 2016 May;54(5):636-46.\u00a0<\/span>doi<\/g>: 10.1165\/rcmb.2016-0045PS. Review.<\/span><\/p>\n

Inflammasome as a New Therapeutic Target for Diabetic Complications.
<\/a>Volpe CM, Anjos PM, Nogueira-Machado JA.
<\/span>Recent Pat Endocr Metab Immune Drug Discov. 2016;10(1):56-62. Review.<\/span><\/p>\n

Upregulation<\/g>\u00a0of inflammasome activity and increased gut permeability are associated with\u00a0obesity\u00a0in children and adolescents.
<\/a>Rainone V, Schneider L, Saulle I, Ricci C, Biasin M, Al-Daghri NM, Giani E, Zuccotti GV, Clerici M, Trabattoni D.
<\/span>Int J Obes (Lond). 2016 Jun;40(6):1026-33.\u00a0<\/span>doi<\/g>: 10.1038\/ijo.2016.26. Epub 2016 Feb 15.<\/span><\/p>\n

Activation of the dsRNA-Activated Protein Kinase PKR in Mitochondrial Dysfunction and Inflammatory Stress in Metabolic Syndrome.
<\/a>Sud N, Rutledge AC, Pan K, Su Q.]
<\/span>Curr Pharm Des. 2016;22(18):2697-703. Review.<\/p>\n

Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice.
<\/a>Mardare C, Kr\u00fcger K, Liebisch G, Seimetz M, Couturier A, Ringseis R, Wilhelm J, Weissmann N, Eder K, Mooren FC.
<\/span>J Diabetes Res. 2016;2016:4536470.\u00a0<\/span>doi<\/g>: 10.1155\/2016\/4536470. Epub 2015 Dec 14.<\/span><\/p>\n

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents.
<\/a>Kursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S.
<\/span>Diabetes. 2016 Mar;65(3):610-8.\u00a0doi<\/g>: 10.2337\/db15-1478. Epub 2015 Dec 30.<\/p>\n

Suppression of\u00a0NLRP3\u00a0inflammasome by \u03b3-tocotrienol ameliorates type 2 diabetes.
<\/a>Kim Y, Wang W, Okla M, Kang I, Moreau R, Chung S.
<\/span>J Lipid Res. 2016 Jan;57(1):66-76. doi: 10.1194\/jlr.M062828. Epub 2015 Dec 1.<\/span><\/p>\n

Caspase-12, but Not Caspase-11, Inhibits\u00a0Obesity\u00a0and Insulin Resistance.
<\/a>Skeldon AM, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, Caprio S, Mehal WZ, Saleh M.
<\/span>J Immunol. 2016 Jan 1;196(1):437-47.\u00a0<\/span>doi<\/g>: 10.4049\/jimmunol.1501529. Epub 2015 Nov 18.<\/span><\/p>\n

Innate immunity in diabetes and diabetic nephropathy.
<\/a>Wada J, Makino H.
<\/span>Nat Rev Nephrol. 2016 Jan;12(1):13-26.\u00a0<\/span>doi<\/g>: 10.1038\/nrneph.2015.175. Epub 2015 Nov 16. Review.<\/span><\/p>\n

Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice.
<\/a>Handa P, Morgan-Stevenson V, Maliken BD, Nelson JE, Washington S, Westerman M, Yeh MM, Kowdley KV.
<\/span>Am J Physiol Gastrointest Liver Physiol. 2016 Jan 15;310(2)<\/span>:G117-27<\/g>.\u00a0<\/span>doi<\/g>: 10.1152\/ajpgi.00246.2015. Epub 2015 Nov 12.<\/span><\/p>\n

NLR family pyrin\u00a0domain containing<\/g>\u00a03 (NLRP3) inflammasome gene polymorphism rs7512998 (C>T) predicts\u00a0aging-related<\/g>\u00a0increase of blood pressure, the\u00a0TAMRISK<\/g>\u00a0study.
<\/a>Kunnas T, M\u00e4\u00e4tt\u00e4 K, Nikkari ST.
<\/span>Immun Ageing. 2015 Oct 31;12:19. doi: 10.1186\/s12979-015-0047-7. eCollection 2015.<\/span><\/p>\n

Activation of the\u00a0NLRP3\u00a0inflammasome induces vascular dysfunction in obese OLETF rats.
<\/a>Liu P, Xie Q, Wei T, Chen Y, Chen H, Shen W.
<\/span>Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):319-25. doi: 10.1016\/j.bbrc.2015.10.105. Epub 2015 Oct 26.<\/span><\/p>\n

Maternal high-fat diet-induced\u00a0programing\u00a0of gut taste receptor and inflammatory gene expression in rat offspring is ameliorated by CLA supplementation.
<\/a>Reynolds CM, Segovia SA, Zhang XD, Gray C, Vickers MH.
<\/span>Physiol Rep. 2015 Oct;3(10).\u00a0<\/span>pii<\/g>: e12588.\u00a0<\/span>doi<\/g>: 10.14814\/phy2.12588.<\/span><\/p>\n

Combined Mulberry Leaf and Fruit Extract Improved Early Stage of Cutaneous Wound Healing in High-Fat Diet-Induced Obese Mice.
<\/a>Eo H, Lim Y.
<\/span>J Med Food. 2016 Feb;19(2):161-9.\u00a0<\/span>doi<\/g>: 10.1089\/jmf.2015.3510. Epub 2015 Oct 22.<\/span><\/p>\n

Is immunity a mechanism contributing to statin-induced diabetes?
<\/a>Henriksbo BD, Schertzer JD.
<\/span>Adipocyte. 2015 Apr 20;4(4):232-8. doi: 10.1080\/21623945.2015.1024394. eCollection 2015 Oct-Dec. Review.<\/p>\n

Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in\u00a0Obesity.
<\/a>Camell CD, Nguyen KY, Jurczak MJ, Christian BE, Shulman GI, Shadel GS, Dixit VD.
<\/span>J Biol Chem. 2015 Dec 4;290(49):29402-13. doi: 10.1074\/jbc.M115.680199. Epub 2015 Oct 5.<\/span><\/p>\n

Effect of Roux-en-Y Gastric Bypass on the\u00a0NLRP3\u00a0Inflammasome in Adipose Tissue from Obese Rats.
<\/a>Mocanu AO, Mulya A, Huang H, Dan O, Shimizu H, Batayyah E, Brethauer SA, Dinischiotu A, Kirwan JP.
<\/span>PLoS One. 2015 Oct 5;10(10):e0139764. doi: 10.1371\/journal.pone.0139764. eCollection 2015.<\/span><\/p>\n

ER stress induces\u00a0NLRP3\u00a0inflammasome activation and hepatocyte death.
<\/a>Lebeaupin C, Proics E, de Bieville CH, Rousseau D, Bonnafous S, Patouraux S, Adam G, Lavallard VJ, Rovere C, Le Thuc O, Saint-Paul MC, Anty R, Schneck AS, Iannelli A, Gugenheim J, Tran A, Gual P, Bailly-Maitre B.
<\/span>Cell Death Dis. 2015 Sep 10;6:e1879. doi: 10.1038\/cddis.2015.248.<\/span><\/p>\n

Instigation of endothelial\u00a0Nlrp3\u00a0inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1.
<\/a>Chen Y, Pitzer AL, Li X, Li PL, Wang L, Zhang Y.
<\/span>J Cell Mol Med. 2015 Dec;19(12):2715-27.\u00a0<\/span>doi<\/g>: 10.1111\/jcmm.12657. Epub 2015 Aug 20.<\/span><\/p>\n

Expression<\/g>\u00a0of\u00a0NLRP3\u00a0in subcutaneous adipose tissue is associated with coronary atherosclerosis.
<\/a>Bando S, Fukuda D, Soeki T, Nishimoto S, Uematsu E, Matsuura T, Ise T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
<\/span>Atherosclerosis. 2015 Oct;242(2):407-14. doi: 10.1016\/j.atherosclerosis.2015.07.043. Epub 2015 Jul 29.<\/span><\/p>\n

Sodium butyrate alleviates adipocyte inflammation by inhibiting\u00a0NLRP3<\/g>\u00a0pathway.
<\/a>Wang X, He G, Peng Y, Zhong W, Wang Y, Zhang B.
<\/span>Sci Rep. 2015 Aug 3;5:12676. doi: 10.1038\/srep12676.<\/span><\/p>\n

Is interleukin-1\u03b2 a culprit in macrophage-adipocyte crosstalk in\u00a0obesity?
<\/a>Bing C.
<\/span>Adipocyte. 2015 Jan 7;4(2):149-52. doi: 10.4161\/21623945.2014.979661. eCollection 2015 Apr-Jun.<\/span><\/p>\n

Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases.
<\/a>Garcia-Martinez I, Shaker ME, Mehal WZ.
<\/span>Antioxid Redox Signal. 2015 Dec 10;23(17):1305-15.\u00a0<\/span>doi<\/g>: 10.1089\/ars.2015.6383. Epub 2015 Jul 27. Review.<\/span><\/p>\n

Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP\/NLRP3\u00a0inflammasome activation in an AMPK dependent manner.
<\/a>Li Y, Yang J, Chen MH, Wang Q, Qin MJ, Zhang T, Chen XQ, Liu BL, Wen XD.
<\/span>Pharmacol Res. 2015 Sep;99:101-15. doi: 10.1016\/j.phrs.2015.05.012. Epub 2015 Jun 6.<\/span><\/p>\n

Galectin-3 Ablation Enhances Liver\u00a0Steatosis,<\/g>\u00a0but Attenuates Inflammation and IL-33-Dependent Fibrosis in Obesogenic Mouse Model of Nonalcoholic Steatohepatitis.
<\/a>Jeftic I, Jovicic N, Pantic J, Arsenijevic N, Lukic ML, Pejnovic N.
<\/span>Mol Med. 2015 May 22;21:453-65.\u00a0<\/span>doi<\/g>: 10.2119\/molmed.2014.00178.<\/span><\/p>\n

Epidermal Fatty Acid binding protein promotes skin inflammation induced by\u00a0high-fat<\/g>\u00a0diet.
<\/a>Zhang Y, Li Q, Rao E, Sun Y, Grossmann ME, Morris RJ, Cleary MP, Li B.
<\/span>Immunity. 2015 May 19;42(5):953-964. doi: 10.1016\/j.immuni.2015.04.016<\/span>\u00a0<\/span><\/p>\n

Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating\u00a0NLRP3\u00a0Inflammasome in a Rodent Model of Type 2 Diabetes.
<\/a>Lee HJ, Hong YS, Jun W, Yang SJ.
<\/span>J Med Food. 2015 Nov;18(11):1207-13.\u00a0<\/span>doi<\/g>: 10.1089\/jmf.2015.3439. Epub 2015 May 14.<\/span><\/p>\n

NLRP3\u00a0at the interface of metabolism and inflammation.
<\/a>Haneklaus M, O’Neill LA.
<\/span>Immunol Rev. 2015 May;265(1):53-62.\u00a0<\/span>doi<\/g>: 10.1111\/imr.12285. Review.<\/span><\/p>\n

Oral Infections, Metabolic Inflammation, Genetics, and Cardiometabolic Diseases.
<\/a>Janket SJ, Javaheri H, Ackerson LK, Ayilavarapu S, Meurman JH.
<\/span>J Dent Res. 2015 Sep;94(9 Suppl):119S-27S.\u00a0<\/span>doi<\/g>: 10.1177\/0022034515580795. Epub 2015 Apr 3. Review.<\/span><\/p>\n

Fish-oil-derived n-3 PUFAs reduce inflammatory and chemotactic adipokine-mediated cross-talk between co-cultured murine splenic CD8+ T cells and adipocytes.
<\/a>Monk JM, Liddle DM, De Boer AA, Brown MJ, Power KA, Ma DW, Robinson LE.
<\/span>J Nutr. 2015 Apr;145(4):829-38. doi: 10.3945\/jn.114.205443. Epub 2015 Feb 4.<\/span><\/p>\n

Exercise and inflammation-related epigenetic modifications: focus on DNA methylation.
<\/a>Horsburgh S, Robson-Ansley P, Adams R, Smith C.
<\/span>Exerc Immunol Rev. 2015;21:26-41. Review.<\/span><\/p>\n

Metabolic signals and innate immune activation in\u00a0obesity\u00a0and exercise.
<\/a>Ringseis R, Eder K, Mooren FC, Kr\u00fcger K.
<\/span>Exerc Immunol Rev. 2015;21:58-68. Review.<\/span><\/p>\n

Purinergic signaling modulates human visceral adipose inflammatory responses: implications in metabolically unhealthy\u00a0obesity.
<\/a>Pandolfi J, Ferraro A, Lerner M, Serrano JR, Dueck A, Fainboim L, Arruvito L.
<\/span>J Leukoc Biol. 2015 May;97(5):941-949.\u00a0<\/span>doi<\/g>: 10.1189\/jlb.3A1214-626R. Epub 2015 Feb 25.<\/span><\/p>\n

The ketone metabolite \u03b2-hydroxybutyrate blocks\u00a0NLRP3\u00a0inflammasome-mediated inflammatory disease.
<\/a>Youm<\/g>\u00a0YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D’Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD.
<\/span>Nat Med. 2015 Mar;21(3):263-9.\u00a0<\/span>doi<\/g>: 10.1038\/nm.3804. Epub 2015 Feb 16.<\/span><\/p>\n

Monounsaturated fatty acid-enriched high-fat diets impede adipose\u00a0NLRP3\u00a0inflammasome-mediated IL-1\u03b2 secretion and insulin resistance despite\u00a0obesity.
<\/a>Finucane OM, Lyons CL, Murphy AM, Reynolds CM, Klinger R, Healy NP, Cooke AA, Coll RC, McAllan L, Nilaweera KN, O’Reilly ME, Tierney AC, Morine MJ, Alcala-Diaz JF, Lopez-Miranda J, O’Connor DP, O’Neill LA, McGillicuddy FC, Roche HM.
<\/span>Diabetes. 2015 Jun;64(6):2116-28.\u00a0<\/span>doi<\/g>: 10.2337\/db14-1098. Epub 2015 Jan 27.<\/span><\/p>\n

NLRP3\u00a0inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.
<\/a>Abderrazak A, Syrovets T, Couchie D, El Hadri K, Friguet B, Simmet T, Rouis M.
<\/span>Redox Biol. 2015;4:296-307. doi: 10.1016\/j.redox.2015.01.008. Epub 2015 Jan 14. Review.<\/span><\/p>\n

Hematopoietic IKBKE limits the chronicity of inflammasome priming and\u00a0metaflammation<\/g>.
<\/a>Patel MN, Bernard WG, Milev NB, Cawthorn WP, Figg N, Hart D, Prieur X, Virtue S, Hegyi K, Bonnafous S, Bailly-Maitre B, Chu Y, Griffin JL, Mallat Z, Considine RV, Tran A, Gual P, Takeuchi O, Akira S, Vidal-Puig A, Bennett MR, Sethi JK.
<\/span>Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):506-11. doi: 10.1073\/pnas.1414536112. Epub 2014 Dec 24.<\/span><\/p>\n

Mitochondria: diversity in the regulation of the\u00a0NLRP3\u00a0inflammasome.
<\/a>Gurung P, Lukens JR, Kanneganti TD.
<\/span>Trends Mol Med. 2015 Mar;21(3):193-201.\u00a0<\/span>doi<\/g>: 10.1016\/j.molmed.2014.11.008. Epub 2014 Nov 27. Review.<\/span><\/p>\n

Macrophage CGI-58 deficiency promotes IL-1\u03b2 transcription by activating the SOCS3-FOXO1 pathway.
<\/a>Miao H, Ou J, Zhang X, Chen Y, Xue B, Shi H, Gan L, Yu L, Liang H.
<\/span>Clin Sci (Lond). 2015 Apr;128(8):493-506. doi: 10.1042\/CS20140414.<\/span><\/p>\n

Isoliquiritigenin is a potent inhibitor of\u00a0NLRP3\u00a0inflammasome activation and diet-induced adipose tissue inflammation.
<\/a>Honda H, Nagai Y, Matsunaga T, Okamoto N, Watanabe Y, Tsuneyama K, Hayashi H, Fujii I, Ikutani M, Hirai Y, Muraguchi A, Takatsu K.
<\/span>J Leukoc Biol. 2014 Dec;96(6):1087-100.\u00a0<\/span>doi<\/g>: 10.1189\/jlb.3A0114-005RR. Epub 2014 Sep 10.<\/span><\/p>\n

Free fatty acids as modulators of the\u00a0NLRP3\u00a0inflammasome in\u00a0obesity\/type 2 diabetes.
<\/a>Legrand-Poels S, Esser N, L’homme L, Scheen A, Paquot N, Piette J.
<\/span>Biochem Pharmacol. 2014 Nov 1;92(1):131-41. doi: 10.1016\/j.bcp.2014.08.013. Epub 2014 Aug 28. Review.<\/span><\/p>\n

Inhibition of the nucleotide-binding domain, leucine-rich containing family, pyrin-domain containing 3\u00a0inflammasomereduces<\/g>\u00a0the severity of experimentally induced acute pancreatitis in obese mice.
<\/a>York JM, Castellanos KJ, Cabay RJ, Fantuzzi G.<\/span><\/p>\n

Transl Res. 2014 Oct;164(4):259-69. doi: 10.1016\/j.trsl.2014.06.012. Epub 2014 Aug 15.<\/span><\/p>\n

Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in\u00a0obesity-induced adipose inflammation.
<\/a>Yin Z, Deng T, Peterson LE, Yu R, Lin J, Hamilton DJ, Reardon PR, Sherman V,\u00a0<\/span>Winnier<\/g>\u00a0GE, Zhan M, Lyon CJ, Wong ST, Hsueh WA.
<\/span>Mol Cell Endocrinol. 2014 Aug 25;394(1-2):80-7.\u00a0<\/span>doi<\/g>: 10.1016\/j.mce.2014.06.018. Epub 2014 Jul 7.<\/span><\/p>\n

Interactions between\u00a0differential<\/g>\u00a0fatty acids and inflammatory stressors-impact on metabolic health.
<\/a>Murphy AM, Lyons CL, Finucane OM, Roche HM.
<\/span>Prostaglandins Leukot Essent Fatty Acids. 2015 Jan;92:49-55.\u00a0<\/span>doi<\/g>: 10.1016\/j.plefa.2014.05.003. Epub 2014 Jun 3. Review.<\/span><\/p>\n

Fluvastatin causes\u00a0NLRP3\u00a0inflammasome-mediated adipose insulin resistance.
<\/a>Henriksbo<\/g>\u00a0BD, Lau TC, Cavallari JF, Denou E, Chi W, Lally JS, Crane JD, Duggan BM, Foley KP, Fullerton MD, Tarnopolsky MA, Steinberg GR, Schertzer JD.
<\/span>Diabetes. 2014 Nov;63(11):3742-7.\u00a0<\/span>doi<\/g>: 10.2337\/db13-1398. Epub 2014 Jun 10.<\/span><\/p>\n

Inflammasomes: molecular regulation and implications for metabolic and cognitive diseases.
<\/a>Choi AJ, Ryter SW.
<\/span>Mol Cells. 2014 Jun;37(6):441-8.\u00a0<\/span>doi<\/g>: 10.14348\/molcells.2014.0104. Epub 2014 May 19. Review.<\/span><\/p>\n

Adipose tissue macrophages promote myelopoiesis and monocytosis in\u00a0obesity.
<\/a>Nagareddy PR, Kraakman M, Masters SL, Stirzaker RA, Gorman DJ, Grant RW, Dragoljevic D, Hong ES, Abdel-Latif A, Smyth SS, Choi SH, Korner J, Bornfeldt KE, Fisher EA, Dixit VD, Tall AR, Goldberg IJ, Murphy AJ.
<\/span>Cell Metab. 2014 May 6;19(5):821-35. doi: 10.1016\/j.cmet.2014.03.029.<\/span><\/p>\n

Inflammation as a link between\u00a0obesity, metabolic syndrome and type 2 diabetes.
<\/a>Esser N, Legrand-Poels S, Piette J, Scheen AJ, Paquot N.
<\/span>Diabetes Res Clin Pract. 2014 Aug;105(2):141-50.\u00a0<\/span>doi<\/g>: 10.1016\/j.diabres.2014.04.006. Epub 2014 Apr 13. Review.<\/span><\/p>\n

Purple sweet potato color ameliorates kidney damage via inhibiting oxidative\u00a0stress mediated<\/g>\u00a0NLRP3inflammasome activation in\u00a0high fat<\/g>\u00a0diet mice.
<\/a>Shan Q, Zheng Y, Lu J, Zhang Z, Wu D, Fan S, Hu B, Cai X, Cai H, Liu P, Liu F.
<\/span>Food Chem Toxicol. 2014 Jul;69:339-46. doi: 10.1016\/j.fct.2014.04.033. Epub 2014 Apr 30.<\/span><\/p>\n

NLRPs, microbiota, and gut homeostasis:\u00a0unravelling<\/g>\u00a0the connection.
<\/a>Zambetti LP, Mortellaro A.
<\/span>J Pathol. 2014 Aug;233(4):321-30.\u00a0<\/span>doi<\/g>: 10.1002\/path.4357. Epub 2014 May 16. Review.<\/span><\/p>\n

Macrophage CGI-58 deficiency activates\u00a0ROS-inflammasome<\/g>\u00a0pathway to promote insulin resistance in mice.
<\/a>Miao H, Ou J, Ma Y, Guo F, Yang Z, Wiggins M, Liu C, Song W, Han X, Wang M, Cao Q, Chung BH, Yang D, Liang H, Xue B, Shi H, Gan L, Yu L.
<\/span>Cell Rep. 2014 Apr 10;7(1):223-35. doi: 10.1016\/j.celrep.2014.02.047. Epub 2014 Apr 3.<\/span><\/p>\n

Endothelial\u00a0NLRP3\u00a0inflammasome activation and enhanced neointima formation in mice by adipokine visfatin.
<\/a>Xia M, Boini KM, Abais JM, Xu M, Zhang Y, Li PL.
<\/span>Am J Pathol. 2014 May;184(5):1617-28.\u00a0<\/span>doi<\/g>: 10.1016\/j.ajpath.2014.01.032. Epub 2014 Mar 13.<\/span><\/p>\n

Resveratrol ameliorates hepatic\u00a0metaflammation<\/g>\u00a0and inhibits\u00a0NLRP3\u00a0inflammasome activation.
<\/a>Yang SJ, Lim Y.
<\/span>Metabolism. 2014 May;63(5):693-701. doi: 10.1016\/j.metabol.2014.02.003. Epub 2014 Feb 11.<\/span><\/p>\n

Physiologic versus diabetogenic effects of interleukin-1: a question of weight.
<\/a>Besedovsky HO, Del Rey A.
<\/span>Curr Pharm Des. 2014;20(29):4733-40. Review.<\/span><\/p>\n

T cell-derived IL-22 amplifies IL-1\u03b2-driven inflammation in human adipose tissue: relevance to\u00a0obesityand<\/g>\u00a0type 2 diabetes.
<\/a>Dalmas E, Venteclef N, Caer C, Poitou C, Cremer I, Aron-Wisnewsky J, Lacroix-Desmazes S, Bayry J, Kaveri SV, Cl\u00e9ment K, Andr\u00e9 S, Guerre-Millo M.
<\/span>Diabetes. 2014 Jun;63(6):1966-77.\u00a0<\/span>doi<\/g>: 10.2337\/db13-1511. Epub 2014 Feb 11.<\/span><\/p>\n


An innate link between\u00a0obesity\u00a0and asthma.
<\/a>Celed\u00f3n JC, Kolls JK.
<\/span>Nat Med. 2014 Jan;20(1):19-20.\u00a0<\/span>doi<\/g>: 10.1038\/nm.3433. No abstract available.\u00a0<\/span><\/p>\n

 <\/p>\n

[NLRP3\u00a0inflammasome and visceral adipose tissue].
<\/a>Esser N, Legrand-Poels S, Piette J, Paquot N, Scheen AJ.
<\/span>Rev Med Liege. 2014;69 Spec No:57-61. French.\u00a0<\/span><\/p>\n

Nlrp3\u00a0is a key modulator of diet-induced nephropathy and renal cholesterol accumulation.
<\/a>Bakker PJ, Butter LM, Kors L, Teske GJ, Aten J, Sutterwala FS, Florquin S, Leemans JC.
<\/span>Kidney Int. 2014 May;85(5):1112-22.\u00a0<\/span>doi<\/g>: 10.1038\/ki.2013.503. Epub 2013 Dec 18.<\/span><\/p>\n

Interleukin-17-producing innate lymphoid cells and the\u00a0NLRP3\u00a0inflammasome facilitate\u00a0obesity-associated airway hyperreactivity.
<\/a>Kim HY, Lee HJ, Chang YJ, Pichavant M, Shore SA, Fitzgerald KA, Iwakura Y, Israel E, Bolger K, Faul J, DeKruyff RH, Umetsu DT.
<\/span>Nat Med. 2014 Jan;20(1):54-61.\u00a0<\/span>doi<\/g>: 10.1038\/nm.3423. Epub 2013 Dec 15.<\/span><\/p>\n

 <\/p>\n

Endoplasmic reticulum stress is sufficient for the induction of IL-1\u03b2 production via activation of the NF-\u03baB and inflammasome pathways.
<\/a>Kim S, Joe Y, Jeong SO, Zheng M, Back SH, Park SW, Ryter SW, Chung HT.
<\/span>Innate Immun. 2014 Nov;20(8):799-815.\u00a0<\/span>doi<\/g>: 10.1177\/1753425913508593. Epub 2013 Nov 11.<\/span><\/p>\n

Thioredoxin-interacting protein is required for endothelial\u00a0NLRP3\u00a0inflammasome activation and cell death in a rat model of\u00a0high-fat<\/g>\u00a0diet.
<\/a>Mohamed IN, Hafez SS, Fairaq A, Ergul A, Imig JD, El-Remessy AB.
<\/span>Diabetologia. 2014 Feb;57(2):413-23. doi: 10.1007\/s00125-013-3101-z. Epub 2013 Nov 8.<\/span><\/p>\n

Lower\u00a0NLRP3\u00a0inflammasome activity in NAG-1 transgenic mice is linked to\u00a0a resistance<\/g>\u00a0to\u00a0obesityand<\/g>\u00a0increased insulin sensitivity.
<\/a>Wang X, Chrysovergis K, Kosak J, Eling TE.
<\/span>Obesity\u00a0(Silver Spring). 2014 May;22(5):1256-63.\u00a0<\/span>doi<\/g>: 10.1002\/oby.20638. Epub 2013 Dec 5.<\/span><\/p>\n

Galectin-3 is a regulator of\u00a0metaflammation<\/g>\u00a0in adipose tissue and pancreatic islets.
<\/a>Pejnovic NN, Pantic JM, Jovanovic IP, Radosavljevic GD, Djukic ALj, Arsenijevic NN, Lukic ML.
<\/span>Adipocyte. 2013 Oct 1;2(4):266-71.\u00a0<\/span>doi<\/g>: 10.4161\/adip.24881. Epub 2013 May 7.<\/span><\/p>\n

Obesity<\/g>\u00a0phenotype is related to\u00a0NLRP3\u00a0inflammasome activity and immunological profile of visceral adipose tissue.
<\/a>Esser N, L’homme L, De Roover A, Kohnen L, Scheen AJ, Moutschen M, Piette J, Legrand-Poels S, Paquot N.
<\/span>Diabetologia. 2013 Nov;56(11):2487-97. doi: 10.1007\/s00125-013-3023-9. Epub 2013 Sep 7.<\/span><\/p>\n

Unsaturated fatty acids prevent activation of\u00a0NLRP3\u00a0inflammasome in human monocytes\/macrophages.
<\/a>L’homme L, Esser N, Riva L, Scheen A, Paquot N, Piette J, Legrand-Poels S.
<\/span>J Lipid Res. 2013 Nov;54(11):2998-3008. doi: 10.1194\/jlr.M037861. Epub 2013 Sep 3.<\/span><\/p>\n

Tipping the inflammatory balance: inflammasome activation distinguishes metabolically unhealthy from healthy\u00a0obesity.
<\/a>Stienstra R, Stefan N.
<\/span>Diabetologia. 2013 Nov;56(11):2343-6. doi: 10.1007\/s00125-013-3040-8. Epub 2013 Sep 1.<\/span><\/p>\n

Activation of the\u00a0Nlrp3\u00a0inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.
<\/a>Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, Tam J, Han T, Mukhopadhyay B, Skarulis MC, Ju C, Aouadi M, Czech MP, Kunos G.
<\/span>Nat Med. 2013 Sep;19(9):1132-40.\u00a0<\/span>doi<\/g>: 10.1038\/nm.3265. Epub 2013 Aug 18.<\/span><\/p>\n

The\u00a0NLRP3\u00a0Inflammasome as a novel player of the intercellular crosstalk in metabolic disorders.
<\/a>Benetti E, Chiazza F, Patel NS, Collino M.
<\/span>Mediators Inflamm. 2013;2013:678627.\u00a0<\/span>doi<\/g>: 10.1155\/2013\/678627. Epub 2013 Jun 13. Review.<\/span><\/p>\n

Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis.
<\/a>Giordano A, Murano I, Mondini E, Perugini J, Smorlesi A, Severi I, Barazzoni R, Scherer PE, Cinti S.
<\/span>J Lipid Res. 2013 Sep;54(9):2423-36. doi: 10.1194\/jlr.M038638. Epub 2013 Jul 8.<\/span><\/p>\n

NLRP3\u00a0inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.
<\/a>Wree<\/g>\u00a0A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, Hoffman HM, Feldstein AE.
<\/span>Hepatology. 2014 Mar;59(3):898-910.\u00a0<\/span>doi<\/g>: 10.1002\/hep.26592. Epub 2014 Jan 30.<\/span><\/p>\n

Cellular and molecular players in adipose tissue inflammation in the development of\u00a0obesity-induced insulin resistance.
<\/a>Lee BC, Lee J.
<\/span>Biochim Biophys Acta. 2014 Mar;1842(3):446-62.\u00a0<\/span>doi<\/g>: 10.1016\/j.bbadis.2013.05.017. Epub 2013 May 22. Review.<\/span><\/p>\n

Mechanisms of disease: inflammasome activation and the development of type 2 diabetes.
<\/a>Grant RW, Dixit VD.
<\/span>Front Immunol. 2013 Mar 8;4:50.\u00a0<\/span>doi<\/g>: 10.3389\/fimmu.2013.00050. eCollection 2013.<\/span><\/p>\n

Galectin-3 deficiency accelerates high-fat diet-induced\u00a0obesity\u00a0and amplifies inflammation in adipose tissue and pancreatic islets.
<\/a>Pejnovic NN, Pantic JM, Jovanovic IP, Radosavljevic GD, Milovanovic MZ, Nikolic IG, Zdravkovic NS, Djukic AL, Arsenijevic NN, Lukic ML.
<\/span>Diabetes. 2013 Jun;62(6):1932-44.\u00a0<\/span>doi<\/g>: 10.2337\/db12-0222. Epub 2013 Jan 24.<\/span><\/p>\n

Autophagy regulates inflammation following oxidative injury in diabetes.
<\/a>Wang Y, Li YB, Yin JJ, Wang Y, Zhu LB, Xie GY, Pan SH.
<\/span>Autophagy. 2013 Mar;9(3):272-7.\u00a0<\/span>doi<\/g>: 10.4161\/auto.23628. Epub 2013 Jan 23. Review.<\/span><\/p>\n

Specific inflammasomes in complex diseases.
<\/a>Masters SL.
<\/span>Clin Immunol. 2013 Jun;147(3):223-8.\u00a0<\/span>doi<\/g>: 10.1016\/j.clim.2012.12.006. Epub 2012 Dec 21. Review.<\/span><\/p>\n

Inflammasomes: sensors of metabolic stresses for vascular inflammation.
<\/a>Yin Y, Pastrana JL, Li X, Huang X, Mallilankaraman K, Choi ET, Madesh M, Wang H, Yang XF.
<\/span>Front Biosci (Landmark Ed). 2013 Jan 1;18:638-49. Review.<\/span><\/p>\n

Mice fed with a\u00a0high fat<\/g>\u00a0diet show a decrease in the expression of “toll like<\/g>\u00a0receptor (TLR)2 and TLR6 mRNAs in adipose and hepatic tissues.
<\/a>Betanzos-Cabrera G, Estrada-Luna D, Belefant-Miller H, Cancino-D\u00edaz JC.
<\/span>Nutr Hosp. 2012 Jul-Aug;27(4):1196-203. doi: 10.3305\/nh.2012.27.4.5842.<\/span><\/p>\n

Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-\u03b4 agonism correlates with impaired\u00a0NLRP3\u00a0inflammasome activation.
<\/a>Collino M, Benetti E, Rogazzo M, Mastrocola R, Yaqoob MM, Aragno M, Thiemermann C, Fantozzi R.
<\/span>Biochem Pharmacol. 2013 Jan 15;85(2):257-64. doi: 10.1016\/j.bcp.2012.10.014. Epub 2012 Oct 24.<\/span><\/p>\n

CCAAT\/enhancer-binding protein \u03b2 (C\/EBP\u03b2) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice.
<\/a>Rahman SM, Janssen RC, Choudhury M, Baquero KC, Aikens RM, de la Houssaye BA, Friedman JE.
<\/span>J Biol Chem. 2012 Oct 5;287(41):34349-60. doi: 10.1074\/jbc.M112.410613. Epub 2012 Aug 19.<\/span><\/p>\n

Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family.
<\/a>Tack CJ, Stienstra R, Joosten LA, Netea MG.
<\/span>Immunol Rev. 2012 Sep;249(1):239-52. doi: 10.1111\/j.1600-065X.2012.01145.x. Review.<\/span><\/p>\n

Adipose tissue inflammation and ectopic lipid accumulation.
<\/a>Suganami T, Tanaka M, Ogawa Y.
<\/span>Endocr J. 2012;59(10):849-57. Epub 2012 Aug 9. Review.<\/span><\/p>\n

Elovl6 promotes nonalcoholic steatohepatitis.
<\/a>Matsuzaka T, Atsumi A, Matsumori R, Nie T, Shinozaki H, Suzuki-Kemuriyama N, Kuba M, Nakagawa Y, Ishii K, Shimada M, Kobayashi K, Yatoh S, Takahashi A, Takekoshi K, Sone H, Yahagi N, Suzuki H, Murata S, Nakamuta M, Yamada N, Shimano H.
<\/span>Hepatology. 2012 Dec;56(6):2199-208.\u00a0<\/span>doi<\/g>: 10.1002\/hep.25932.<\/span><\/p>\n

Dietary saturated fatty acids prime the\u00a0NLRP3\u00a0inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance.
<\/a>Reynolds CM, McGillicuddy FC, Harford KA, Finucane OM, Mills KH, Roche HM.
<\/span>Mol Nutr Food Res. 2012 Aug;56(8):1212-22.\u00a0doi: 10.1002\/mnfr.201200058. Epub 2012 Jun 15.<\/span><\/p>\n

A role for the\u00a0NLRP3\u00a0inflammasome in metabolic diseases–did Warburg miss inflammation?
<\/a>Wen H, Ting JP, O’Neill LA.
<\/span>Nat Immunol. 2012 Mar 19;13(4):352-7.\u00a0doi: 10.1038\/ni.2228. Review.<\/span><\/p>\n

Inflammaging: disturbed interplay between autophagy and inflammasomes.
<\/a>Salminen A, Kaarniranta K, Kauppinen A.
<\/span>Aging (Albany NY). 2012 Mar;4(3):166-75.<\/span><\/p>\n

Inflammasome-mediated dysbiosis regulates progression of NAFLD and\u00a0obesity.
<\/a>Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA.
<\/span>Nature. 2012 Feb 1;482(7384):179-85. doi: 10.1038\/nature10809.<\/span>\u00a0<\/span><\/p>\n

Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)-1 and an emerging role for cytokines beyond IL-1.
<\/a>Goldbach-Mansky R.
<\/span>Clin Exp Immunol. 2012 Mar;167(3):391-404. doi: 10.1111\/j.1365-2249.2011.04533.x. Review.<\/span><\/p>\n

The inflammasome: in memory of Dr. Jurg Tschopp.
<\/a>Dagenais M, Skeldon A, Saleh M.
<\/span>Cell Death Differ. 2012 Jan;19(1):5-12.\u00a0doi: 10.1038\/cdd.2011.159. Epub 2011 Nov 11.<\/span><\/p>\n

Nucleotide-binding oligomerization domain-like receptors and inflammasomes in the pathogenesis of non-microbial inflammation and diseases.
<\/a>Mason DR, Beck PL, Muruve DA.
<\/span>J Innate Immun. 2012;4(1):16-30.\u00a0doi: 10.1159\/000334247. Epub 2011 Nov 4. Review.<\/span>\u00a0<\/span><\/p>\n

Inflammation as a sensor of metabolic stress in\u00a0obesity\u00a0and type 2 diabetes.
<\/a>Donath MY.
<\/span>Endocrinology. 2011 Nov;152(11):4005-6.\u00a0doi: 10.1210\/en.2011-1691. No abstract available.\u00a0<\/p>\n

Inflammasome\u00a0is a central player in the induction of\u00a0obesity\u00a0and insulin resistance.
<\/a>Stienstra R, van Diepen JA, Tack CJ, Zaki MH, van de Veerdonk FL, Perera D, Neale GA, Hooiveld GJ, Hijmans A, Vroegrijk I, van den Berg S, Romijn J, Rensen PC, Joosten LA, Netea MG, Kanneganti TD.
<\/span>Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15324-9.\u00a0doi: 10.1073\/pnas.1100255108. Epub 2011 Aug 29.<\/span><\/p>\n

Elimination of the\u00a0NLRP3-ASC inflammasome protects against chronic\u00a0obesity-induced pancreatic damage.
<\/a>Youm YH, Adijiang A, Vandanmagsar B, Burk D, Ravussin A, Dixit VD.
<\/span>Endocrinology. 2011 Nov;152(11):4039-45.\u00a0doi: 10.1210\/en.2011-1326. Epub 2011 Aug 23.<\/span><\/p>\n

NLRP3\u00a0inflammasomes link inflammation and metabolic disease.
<\/a>De Nardo D, Latz E.
<\/span>Trends Immunol. 2011 Aug;32(8):373-9.\u00a0doi: 10.1016\/j.it.2011.05.004. Epub 2011 Jul 4. Review.<\/span><\/p>\n

Role of innate immunity in diabetes and metabolism: recent progress in the study of inflammasomes.
<\/a>Lee MS.
<\/span>Immune Netw. 2011 Apr;11(2):95-9.\u00a0doi: 10.4110\/in.2011.11.2.95. Epub 2011 Apr 30.<\/span><\/p>\n

Adipose and liver expression of interleukin (IL)-1 family members in morbid\u00a0obesity\u00a0and effects of weight loss.
<\/a>Moschen AR, Molnar C, Enrich B, Geiger S, Ebenbichler CF, Tilg H.
<\/span>Mol Med. 2011;17(7-8):840-5. doi: 10.2119\/molmed.2010.00108. Epub 2011 Mar 2.<\/span><\/p>\n

The\u00a0NLRP3\u00a0inflammasome instigates\u00a0obesity-induced inflammation and insulin resistance.
<\/a>Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL, Ravussin E, Stephens JM, Dixit VD.
<\/span>Nat Med. 2011 Feb;17(2):179-88.\u00a0doi: 10.1038\/nm.2279. Epub 2011 Jan 9.<\/span><\/p>\n

The inflammasome-mediated\u00a0caspase-1 activation controls adipocyte differentiation and insulin sensitivity.
<\/a>Stienstra R, Joosten LA, Koenen T, van Tits B, van Diepen JA, van den Berg SA, Rensen PC, Voshol PJ, Fantuzzi G, Hijmans A, Kersten S, M\u00fcller M, van den Berg WB, van Rooijen N, Wabitsch M, Kullberg BJ, van der Meer JW, Kanneganti T, Tack CJ, Netea MG.
<\/span>Cell Metab. 2010 Dec 1;12(6):593-605. doi: 10.1016\/j.cmet.2010.11.011.<\/span><\/p>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″] Obesity and NLRP3   Sleeve Gastroplasty Combined with the\u00a0NLRP3\u00a0Inflammasome Inhibitor CY-09 Reduces Body Weight, Improves Insulin Resistance and Alleviates Hepatic Steatosis […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/917"}],"collection":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/comments?post=917"}],"version-history":[{"count":6,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/917\/revisions"}],"predecessor-version":[{"id":941,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/917\/revisions\/941"}],"wp:attachment":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/media?parent=917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}