{"id":892,"date":"2020-04-09T18:05:45","date_gmt":"2020-04-09T18:05:45","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=892"},"modified":"2020-04-10T16:17:12","modified_gmt":"2020-04-10T16:17:12","slug":"sulforaphane-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/sulforaphane-and-nlrp3\/","title":{"rendered":"Sulforaphane and NLRP3"},"content":{"rendered":"

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Sulforaphane and NLRP3<\/u><\/strong><\/h4>\n

Sulforaphane<\/strong>\u00a0<\/span>Prevents Right Ventricular Injury and Reduces Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
<\/a>Kang Y, Zhang G, Huang EC, Huang J, Cai J, Cai L, Wang S, Keller BB.
<\/span>Am J Physiol Heart Circ Physiol<\/span>. 2020 Feb 28. <\/span>doi<\/g>: 10.1152\/ajpheart.00321.2019. [Epub ahead of print]<\/span><\/p>\n

Sulforaphane<\/strong>\u00a0<\/span>alleviates retinal ganglion cell death and inflammation by suppressing\u00a0<\/span>NLRP3<\/strong>inflammasome activation in a rat model of retinal ischemia\/reperfusion
injury.
<\/a>Gong Y, Cao X, Gong L, Li W.
<\/span>Int J Immunopathol Pharmacol<\/span>. 2019 Jan-Dec;33:2058738419861777. <\/span>doi<\/g>: 10.1177\/2058738419861777.<\/span><\/p>\n

Protective effects of\u00a0<\/span>sulforaphane<\/strong>\u00a0<\/span>on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of\u00a0<\/span>NLRP3<\/strong>\u00a0<\/span>inflammasome formation.
<\/a>Li S, Yang H, Chen X.
<\/span>Exp Anim<\/span>. 2019 May 8;68(2):221-231. <\/span>doi<\/g>: 10.1538\/expanim.18-0146. Epub 2019 Jan 1.<\/span><\/p>\n

Pharmacological Effects and Mechanisms of Chinese Medicines Modulating\u00a0<\/span>NLRP3<\/strong>\u00a0<\/span>Inflammasomes in Ischemic Cardio\/Cerebral Vascular Disease.
<\/a>Li Y, Liu Y, Yan X, Liu Q, Zhao YH, Wang DW.
<\/span>Am J Chin Med<\/span>. 2018;46(8):1727-1741. <\/span>doi<\/g>: 10.1142\/S0192415X18500878. Epub 2018 Dec 10. Review.<\/span><\/p>\n

Suppression of\u00a0<\/span>NLRP3<\/strong>\u00a0<\/span>inflammasome by oral treatment with\u00a0<\/span>sulforaphane<\/strong>\u00a0<\/span>alleviates acute gouty inflammation.
<\/a>Yang G, Yeon SH, Lee HE, Kang HC, Cho YY, Lee HS, Lee JY.
<\/span>Rheumatology (Oxford)<\/span>. 2018 Apr 1;57(4):727-736. <\/span>doi<\/g>: 10.1093\/rheumatology\/kex499.<\/span><\/p>\n

Sulforaphane<\/strong>\u00a0<\/span>improves outcomes and slows cerebral ischemic\/reperfusion injury via inhibition of\u00a0<\/span>NLRP3<\/strong>\u00a0<\/span>inflammasome activation in rats.
<\/a>Yu C, He Q, Zheng J, Li LY, Hou YH, Song FZ.
<\/span>Int Immunopharmacol<\/span>. 2017 Apr;45:74-78. doi: 10.1016\/j.intimp.2017.01.034. Epub 2017 Feb 10.<\/span><\/p>\n

Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer<\/g> disease.
<\/a>Pennisi M, Crupi R, Di Paola R, Ontario ML, Bella R, Calabrese EJ, Crea R, Cuzzocrea S, Calabrese V.
<\/span>J Neurosci Res<\/span>. 2017 Jul;95(7):1360-1372. <\/span>doi<\/g>: 10.1002\/jnr.23986. Epub 2016 Nov 8. Review.<\/span><\/p>\n

Sulforaphane<\/strong>\u00a0<\/span>Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and\u00a0<\/span>NLRP3<\/strong>\u00a0<\/span>Inflammatory Pathway.
<\/a>Dong Z, Shang H, Chen YQ, Pan LL, Bhatia M, Sun J.
<\/span>Oxid Med Cell Longev<\/span>. 2016;2016:7864150. Epub 2016 Oct 26.<\/span><\/p>\n

Sulforaphane<\/strong>\u00a0<\/span>attenuates activation of\u00a0<\/span>NLRP3<\/strong>\u00a0<\/span>and NLRC4 inflammasomes but not AIM2 inflammasome.
<\/a>Lee J, Ahn H, Hong EJ, An BS, Jeung EB, Lee GS.
<\/span>Cell Immunol<\/span>. 2016 Aug-Sep;306-307:53-60. doi: 10.1016\/j.cellimm.2016.07.007. Epub 2016 Jul 12.<\/span><\/p>\n

A pharmacological inhibitor of\u00a0<\/span>NLRP3<\/strong>\u00a0<\/span>inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high<\/g> fat<\/g> diet.
<\/a>Yang G, Lee HE, Lee JY.
<\/span>Sci Rep<\/span>. 2016 Apr 14;6:24399. doi: 10.1038\/srep24399. Erratum in:<\/span>\u00a0<\/span>Sci Rep. 2016 May 20;6:26218<\/a>.<\/span>\u00a0<\/span><\/p>\n

Sulforaphane<\/strong>\u00a0<\/span>exerts its anti-inflammatory effect against amyloid-\u03b2 peptide via STAT-1 dephosphorylation and activation of Nrf2\/HO-1 cascade in human THP-1 macrophages.
<\/a>An YW, Jhang KA, Woo SY, Kang JL, Chong YH.
<\/span>Neurobiol Aging<\/span>. 2016 Feb;38:1-10. doi: 10.1016\/j.neurobiolaging.2015.10.016. Epub 2015 Oct 23.<\/span><\/p>\n

Sulforaphane<\/strong>\u00a0<\/span>inhibits multiple inflammasomes through an Nrf2-independent mechanism.
<\/a>Greaney AJ, Maier NK, Leppla SH, Moayeri M.
<\/span>J Leukoc Biol<\/span>. 2016 Jan;99(1):189-99. <\/span>doi<\/g>: 10.1189\/jlb.3A0415-155RR. Epub 2015 Aug 12.<\/p>\n

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[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″] Sulforaphane and NLRP3 Sulforaphane\u00a0Prevents Right Ventricular Injury and Reduces Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.Kang Y, Zhang G, Huang EC, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/892"}],"collection":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/comments?post=892"}],"version-history":[{"count":4,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/892\/revisions"}],"predecessor-version":[{"id":989,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/892\/revisions\/989"}],"wp:attachment":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/media?parent=892"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}