{"id":884,"date":"2020-04-09T18:01:08","date_gmt":"2020-04-09T18:01:08","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=884"},"modified":"2020-04-10T16:18:58","modified_gmt":"2020-04-10T16:18:58","slug":"egcg-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/egcg-and-nlrp3\/","title":{"rendered":"EGCG and NLRP3"},"content":{"rendered":"

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EGCG and NLRP3<\/o:p><\/span><\/u><\/b><\/h4>\n

Green tea polyphenols and epigallocatechin-3-gallate<\/strong> protect against perfluorodecanoic<\/g> acid induced<\/g> liver damage and inflammation in mice by inhibiting<\/span>\u00a0<\/span><\/span>NLRP3<\/span><\/b>\u00a0<\/span><\/span>inflammasome activation.
<\/span><\/a>Wang D, Gao Q, Wang T, Kan Z, Li X, Hu L, Peng CY, Qian F, Wang Y, Granato D.
<\/span>Food Res Int<\/span>. 2020 Jan;127:108628. doi<\/g>: 10.1016\/j.foodres.2019.108628. Epub 2019 Aug 19.<\/span><\/p>\n

Effects of Flavonoids and Its Derivatives on Immune Cell Responses.
<\/a><\/span>Mart\u00ednez G, Mijares MR, De Sanctis JB.
<\/span>Recent Pat Inflamm Allergy Drug Discov<\/span>. 2019;13(2):84-104. doi<\/g>: 10.2174\/1872213X13666190426164124.<\/span><\/p>\n

Epigallocatechin-3-Gallate<\/strong> Attenuates\u00a0Microglial Inflammation and Neurotoxicity by Suppressing the Activation of Canonical and Noncanonical Inflammasome via TLR4\/NF-\u03baB Pathway.
<\/a><\/span>Zhong X, Liu M, Yao W, Du K, He M, Jin X, Jiao L, Ma G, Wei B, Wei M.
<\/span>Mol Nutr Food Res<\/span>. 2019 Nov;63(21):e1801230. doi<\/g>: 10.1002\/mnfr.201801230. Epub 2019 Aug 16.<\/span><\/p>\n

Epigallocatechin-3-Gallate<\/strong> Prevents Acute Gout by Suppressing<\/span>\u00a0<\/span><\/span>NLRP3<\/span><\/b>\u00a0<\/span><\/span>Inflammasome Activation and Mitochondrial DNA Synthesis.
<\/span><\/a>Lee HE, Yang G, Park YB, Kang HC, Cho YY, Lee HS, Lee JY.
<\/span>Molecules<\/span>. 2019 Jun 6;24(11). pii: E2138. doi: 10.3390\/molecules24112138.<\/span><\/p>\n

Epigallocatechin gallate<\/strong> inhibits urate crystals-induced peritoneal inflammation in C57BL\/6 mice.
<\/a><\/span>Jhang JJ, Lu CC, Yen GC.
<\/span>Mol Nutr Food Res<\/span>. 2016 Oct;60(10):2297-2303. doi<\/g>: 10.1002\/mnfr.201600106. Epub 2016 Jun 16.<\/span><\/p>\n

Targeting HO-1 by Epigallocatechin-3-Gallate<\/strong> Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
<\/a><\/span>Gao Z, Han Y, Hu Y, Wu X, Wang Y, Zhang X, Fu J, Zou X, Zhang J, Chen X, Jose PA, Lu X, Zeng C.
<\/span>PLoS One<\/span>. 2016 Feb 11;11(2):e0149032. doi: 10.1371\/journal.pone.0149032. eCollection 2016.<\/span><\/p>\n

Quercetin, luteolin and epigallocatechin gallate<\/strong> alleviate TXNIP and<\/span>\u00a0<\/span><\/span>NLRP3<\/span><\/b>-mediated inflammation and apoptosis with regulation<\/g> of AMPK in endothelial cells.<\/span><\/a>Wu J, Xu X, Li Y, Kou J, Huang F, Liu B, Liu K.
<\/span>Eur J Pharmacol<\/span>. 2014 Dec 15;745:59-68. doi: 10.1016\/j.ejphar.2014.09.046. Epub 2014 Oct 14.<\/span><\/p>\n

Epigallocatechin-3-gallate<\/strong> prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting<\/span>\u00a0<\/span><\/span>NLRP3<\/span><\/b>\u00a0<\/span><\/span>inflammasome activation.
<\/span><\/a>Tsai PY, Ka SM, Chang JM, Chen HC, Shui HA, Li CY, Hua KF, Chang WL, Huang JJ, Yang SS, Chen A.
<\/span>Free Radic Biol Med<\/span>. 2011 Aug 1;51(3):744-54. doi<\/g>: 10.1016\/j.freeradbiomed.2011.05.016. Epub 2011 May 23.<\/span><\/p>\n

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