{"id":1165,"date":"2020-04-23T10:27:04","date_gmt":"2020-04-23T10:27:04","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=1165"},"modified":"2020-04-23T10:39:54","modified_gmt":"2020-04-23T10:39:54","slug":"hypertension-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/hypertension-and-nlrp3\/","title":{"rendered":"Hypertension and NLRP3"},"content":{"rendered":"

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Hypertension and NLRP3<\/span><\/u><\/b><\/span>
<\/span><\/u><\/b><\/h4>\n

<\/a><\/p>\n

Microglia-Derived\u00a0NLRP3<\/strong>\u00a0Activation Mediates the Pressor Effect of Prorenin in the Rostral Ventrolateral Medulla of Stress-Induced Hypertensive Rats
<\/a>Hu L, Zhang S, Ooi K, Wu X, Wu J, Cai J, Sun Y, Wang J, Zhu D, Chen F, Xia C.
Neurosci Bull. 2020 Apr 3. doi: 10.1007\/s12264-020-00484-9. [Epub ahead of print]<\/p>\n

Apelin\/APJ system: an emerging therapeutic target for respiratory diseases.
<\/a>Yan J, Wang A, Cao J, Chen L.
Cell Mol Life Sci. 2020 Mar 3. doi: 10.1007\/s00018-020-03461-7. [Epub ahead of print] Review.<\/p>\n

Contribution of TGF-Beta-Mediated\u00a0NLRP3<\/strong>-HMGB1 Activation to Tubulointerstitial Fibrosis in Rat With Angiotensin II-Induced Chronic Kidney Disease.
<\/a>Zhang K, Fan C, Cai D, Zhang Y, Zuo R, Zhu L, Cao Y, Zhang J, Liu C, Chen Y, Liang H.
Front Cell Dev Biol. 2020 Feb 5;8:1. doi: 10.3389\/fcell.2020.00001. eCollection 2020.<\/p>\n

Neurological manifestations of autoinflammatory diseases in Chinese adult patients.
<\/a>Qin W, Wu D, Luo Y, Zhao M, Wang Y, Shi X, Zhou L, Yu W, Sun Y, Wang R, Zhang W, Liu M, Shen M.
Semin Arthritis Rheum. 2020 Feb 3. pii: S0049-0172(20)30012-3. doi: 10.1016\/j.semarthrit.2019.12.003. [Epub ahead of print]<\/p>\n

Sulforaphane prevents right ventricular injury and reduces pulmonary vascular remodeling in pulmonary arterial\u00a0hypertension<\/strong>.
<\/a>Kang Y, Zhang G, Huang EC, Huang J, Cai J, Cai L, Wang S, Keller BB.
Am J Physiol Heart Circ Physiol. 2020 Apr 1;318(4):H853-H866. doi: 10.1152\/ajpheart.00321.2019. Epub 2020 Feb 28.<\/p>\n

[Mechanism of microglia promoting retinal ganglion cell death\u00a0in vitro<\/em>].
<\/a>Li F, Jiang N, Zhu YT, Su WR, Zhuo YH.
Zhonghua Yan Ke Za Zhi. 2020 Jan 11;56(1):32-40. doi: 10.3760\/cma.j.issn.0412-4081.2020.01.010. Chinese.\u00a0<\/p>\n

SOD2 ameliorates pulmonary\u00a0hypertension<\/strong>\u00a0in a murine model of sleep apnea via suppressing expression of\u00a0NLRP3<\/strong>\u00a0in CD11b+<\/sub>\u00a0cells.
<\/a>Fu C, Hao S, Liu Z, Xie L, Wu X, Wu X, Li S.
Respir Res. 2020 Jan 8;21(1):9. doi: 10.1186\/s12931-019-1270-0.<\/p>\n

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation.
<\/a>Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, K\u00f6rbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Schuster S, Silbernagel G, Sester M, Sester U, A\u00dfmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, M\u00e4rz W, B\u00f6hm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T.
Nat Immunol. 2020 Jan;21(1):30-41. doi: 10.1038\/s41590-019-0548-1. Epub 2019 Dec 9.<\/p>\n

NLRP3<\/strong>\u00a0Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus.
<\/a>Ferreira NS, Bruder-Nascimento T, Pereira CA, Zanotto CZ, Prado DS, Silva JF, Rassi DM, Foss-Freitas MC, Alves-Filho JC, Carlos D, Tostes RC.
Cells. 2019 Dec 8;8(12). pii: E1595. doi: 10.3390\/cells8121595.<\/p>\n

A new strategy for the treatment of atherothrombosis – inhibition of inflammation.
<\/a>Sl\u00edva J, Charalambous C, Bultas J, Karetov\u00e1 D.
Physiol Res. 2019 Nov 22;68(Suppl 1):S17-S30.<\/p>\n

Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3<\/strong>)-Inflammasome-Dependent Mechanism.
<\/a>Li H, Qian F, Liu H, Zhang Z.
Med Sci Monit. 2019 Nov 10;25:8457-8464. doi: 10.12659\/MSM.916667.<\/p>\n

The Role of Inflammasome-Dependent and Inflammasome-Independent\u00a0NLRP3<\/strong>\u00a0in the Kidney.
<\/a>Kim YG, Kim SM, Kim KP, Lee SH, Moon JY.
Cells. 2019 Nov 5;8(11). pii: E1389. doi: 10.3390\/cells8111389. Review.<\/p>\n

Inhibition of IL-1\u03b2 by Aliskiren Improved Renal AQP2 Expression and Urinary Concentration Defect in Ureteral Obstruction and Release.
<\/a>Hu S, Xie H, Luo R, Feng P, Liu Q, Han M, Kong Y, Zou X, Wang W, Li C.
Front Physiol. 2019 Sep 13;10:1157. doi: 10.3389\/fphys.2019.01157. eCollection 2019.<\/p>\n

Curcumin attenuates migration of vascular smooth muscle cells via inhibiting NF\u03baB-mediated\u00a0NLRP3<\/strong>expression in spontaneously hypertensive rats.
<\/a>Han Y, Sun HJ, Tong Y, Chen YZ, Ye C, Qiu Y, Zhang F, Chen AD, Qi XH, Chen Q, Li YH, Kang YM, Zhu GQ.
J Nutr Biochem. 2019 Oct;72:108212. doi: 10.1016\/j.jnutbio.2019.07.003. Epub 2019 Jul 8.<\/p>\n

Activation of P2X7<\/sub>R-\u00a0NLRP3<\/strong>\u00a0pathway in Retinal microglia contribute to Retinal Ganglion Cells death in chronic ocular\u00a0hypertension<\/strong>\u00a0(COH).
<\/a>Zhang Y, Xu Y, Sun Q, Xue S, Guan H, Ji M.
Exp Eye Res. 2019 Nov;188:107771. doi: 10.1016\/j.exer.2019.107771. Epub 2019 Aug 22.<\/p>\n

Activation of the\u00a0NLRP3<\/strong>\u00a0and AIM2 inflammasomes in a mouse model of\u00a0Schistosoma mansoni<\/em>infection.
<\/a>Chen TTW, Cheng PC, Chang KC, Cao JP, Feng JL, Chen CC, Lam HYP, Peng SY.
J Helminthol. 2019 Aug 15;94:e72. doi: 10.1017\/S0022149X19000622.<\/p>\n

Pathogenic role of innate immunity in a model of chronic NO inhibition associated with salt overload.
<\/a>Zambom FFF, Oliveira KC, Foresto-Neto O, Faustino VD, \u00c1vila VF, Albino AH, Arias SCA, Volpini RA, Malheiros DMAC, Saraiva Camara NO, Zatz R, Fujihara CK.
Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F1058-F1067. doi: 10.1152\/ajprenal.00251.2019. Epub 2019 Aug 14.<\/p>\n

Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats.
<\/a>Qin Q, Lin N, Huang H, Zhang X, Cao X, Wang Y, Li P.
Diabetes Metab Syndr Obes. 2019 Jul 10;12:1091-1103. doi: 10.2147\/DMSO.S208989. eCollection 2019.<\/p>\n

Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation.
<\/a>Messerschmidt L, Fischer S, Wiedemann P, Bringmann A, Hollborn M.
Mol Vis. 2019 Jun 30;25:329-344. eCollection 2019.<\/p>\n

Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications.
<\/a>Zeng C, Wang R, Tan H.
Int J Biol Sci. 2019 May 20;15(7):1345-1357. doi: 10.7150\/ijbs.33568. eCollection 2019. Review.<\/p>\n

Nebivolol improves obesity-induced vascular remodelling by suppressing\u00a0NLRP3<\/strong>\u00a0activation.
<\/a>Gao J, Xie Q, Wei T, Huang C, Zhou W, Shen W.
J Cardiovasc Pharmacol. 2019 Mar 14. doi: 10.1097\/FJC.0000000000000667. [Epub ahead of print]<\/p>\n

Nebivolol Improves Obesity-Induced Vascular Remodeling by Suppressing\u00a0NLRP3<\/strong>\u00a0Activation.
<\/a>Gao J, Xie Q, Wei T, Huang C, Zhou W, Shen W.
J Cardiovasc Pharmacol. 2019 May;73(5):326-333. doi: 10.1097\/FJC.0000000000000667.<\/p>\n

Hydrogen sulfide improves endothelial dysfunction by inhibiting the vicious cycle of\u00a0NLRP3<\/strong>inflammasome and oxidative stress in spontaneously hypertensive rats.
<\/a>Li J, Teng X, Jin S, Dong J, Guo Q, Tian D, Wu Y.
J Hypertens. 2019 Aug;37(8):1633-1643. doi: 10.1097\/HJH.0000000000002101.<\/p>\n

Chrysanthemum indicum extract inhibits\u00a0NLRP3<\/strong>\u00a0and AIM2 inflammasome activation via regulating ASC phosphorylation.
<\/a>Yu SH, Sun X, Kim MK, Akther M, Han JH, Kim TY, Jiang J, Kang TB, Lee KH.
J Ethnopharmacol. 2019 Jul 15;239:111917. doi: 10.1016\/j.jep.2019.111917. Epub 2019 Apr 25.<\/p>\n

Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular\u00a0Hypertension<\/strong>\u00a0Injury.
<\/a>Pronin A, Pham D, An W, Dvoriantchikova G, Reshetnikova G, Qiao J, Kozhekbaeva Z, Reiser AE, Slepak VZ, Shestopalov VI.
Front Mol Neurosci. 2019 Mar 13;12:36. doi: 10.3389\/fnmol.2019.00036. eCollection 2019.<\/p>\n

IL-1\u03b2 Plays an Important Role in Pressure Overload-Induced Atrial Fibrillation in Mice.
<\/a>Matsushita N, Ishida N, Ibi M, Saito M, Takahashi M, Taniguchi S, Iwakura Y, Morino Y, Taira E, Sawa Y, Hirose M.
Biol Pharm Bull. 2019;42(4):543-546. doi: 10.1248\/bpb.b18-00363.<\/p>\n

Obesity and Cardioprotection.
<\/a>Femmin\u00f2 S, Pagliaro P, Penna C.
Curr Med Chem. 2020;27(2):230-239. doi: 10.2174\/0929867326666190325094453.<\/p>\n

NLRP3<\/strong>\u00a0Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs.
<\/a>Zhang X, Hong S, Qi S, Liu W, Zhang X, Shi Z, Chen W, Zhao M, Yin X.
Mediators Inflamm. 2019 Feb 13;2019:6847087. doi: 10.1155\/2019\/6847087. eCollection 2019.<\/p>\n

Activation of Nicotinic Acetylcholine \u03b17 Receptor Attenuates Progression of Monocrotaline-Induced Pulmonary\u00a0Hypertension<\/strong>\u00a0in Rats by Downregulating the\u00a0NLRP3<\/strong>\u00a0Inflammasome.
<\/a>Deng Y, Guo SL, Wei B, Gao XC, Zhou YC, Li JQ.
Front Pharmacol. 2019 Feb 26;10:128. doi: 10.3389\/fphar.2019.00128. eCollection 2019.<\/p>\n

Catheter-based renal sympathetic denervation induces acute renal inflammation through activation of caspase-1 and\u00a0NLRP3<\/strong>\u00a0inflammasome.
<\/a>Lee DW, Kim JS, Kim IY, Kim HS, Kim JY, Rhee H, Seong EY, Song SH, Lee SB, Edelstein CL, Kwak IS.
Anatol J Cardiol. 2019 Mar;21(3):134-141. doi: 10.14744\/AnatolJCardiol.2018.62257.<\/p>\n

circARF3 Alleviates Mitophagy-Mediated Inflammation by Targeting miR-103\/TRAF3 in Mouse Adipose Tissue.
<\/a>Zhang Z, Zhang T, Feng R, Huang H, Xia T, Sun C.
Mol Ther Nucleic Acids. 2019 Mar 1;14:192-203. doi: 10.1016\/j.omtn.2018.11.014. Epub 2018 Dec 1.<\/p>\n

The renal immune-inflammatory component of arterial\u00a0hypertension<\/strong>: emerging therapeutic strategies.
<\/a>Garcia-Fernandez N, Beaumont J, Moreno MU, San Jos\u00e9 G, Gonz\u00e1lez A, D\u00edez J.
Cardiovasc Res. 2019 Mar 15;115(4):696-698. doi: 10.1093\/cvr\/cvy280. No abstract available.\u00a0<\/p>\n

Cathepsin B-Mediated\u00a0NLRP3<\/strong>\u00a0Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion Dysfunction.
<\/a>Lian D, Lai J, Wu Y, Wang L, Chen Y, Zhang Y, Boini KM, Huang Y, Chen Y.
Cell Physiol Biochem. 2018;50(4):1585-1600. doi: 10.1159\/000494656. Epub 2018 Oct 25.<\/p>\n

Pharmacological inhibition of the\u00a0NLRP3<\/strong>\u00a0inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive\u00a0hypertension<\/strong>.
<\/a>Krishnan SM, Ling YH, Huuskes BM, Ferens DM, Saini N, Chan CT, Diep H, Kett MM, Samuel CS, Kemp-Harper BK, Robertson AAB, Cooper MA, Peter K, Latz E, Mansell
AS, Sobey CG, Drummond GR, Vinh A.
Cardiovasc Res. 2019 Mar 15;115(4):776-787. doi: 10.1093\/cvr\/cvy252.<\/p>\n

Salt-Responsive Metabolite, \u03b2-Hydroxybutyrate, Attenuates\u00a0Hypertension<\/strong>.
<\/a>Chakraborty S, Galla S, Cheng X, Yeo JY, Mell B, Singh V, Yeoh B, Saha P, Mathew AV, Vijay-Kumar M, Joe B.
Cell Rep. 2018 Oct 16;25(3):677-689.e4. doi: 10.1016\/j.celrep.2018.09.058.<\/p>\n

The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice.
<\/a>Sogawa Y, Nagasu H, Itano S, Kidokoro K, Taniguchi S, Takahashi M, Kadoya H, Satoh M, Sasaki T, Kashihara N.
PLoS One. 2018 Oct 3;13(10):e0203823. doi: 10.1371\/journal.pone.0203823. eCollection 2018.<\/p>\n

Role of NLRP-3 Inflammasome in\u00a0Hypertension<\/strong>: A Potential Therapeutic Target.
<\/a>Pasqua T, Pagliaro P, Rocca C, Angelone T, Penna C.
Curr Pharm Biotechnol. 2018;19(9):708-714. doi: 10.2174\/1389201019666180808162011. Review.<\/p>\n

Osmotic and hypoxic induction of the complement factor C9 in cultured human retinal pigment epithelial cells: Regulation of VEGF and\u00a0NLRP3<\/strong>\u00a0expression.
<\/a>Hollborn M, Ackmann C, Kuhrt H, Doktor F, Kohen L, Wiedemann P, Bringmann A.
Mol Vis. 2018 Jul 28;24:518-535. eCollection 2018.<\/p>\n

New mitochondrial DNA synthesis enables\u00a0NLRP3<\/strong>\u00a0inflammasome activation.
<\/a>Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M.
Nature. 2018 Aug;560(7717):198-203. doi: 10.1038\/s41586-018-0372-z. Epub 2018 Jul 25.<\/p>\n

Rehydration with fructose worsens dehydration-induced renal damage.
<\/a>Milagres T, Garc\u00eda-Arroyo FE, Lanaspa MA, Garcia G, Ishimoto T, Andres-Hernando A, Kuwabara M, Jensen T, Sato Y, Glaser J, S\u00e1nchez-Lozada LG, Johnson RJ, Roncal
Jimenez C.
BMC Nephrol. 2018 Jul 13;19(1):180. doi: 10.1186\/s12882-018-0963-9.<\/p>\n

Angiotensin II Stimulates the\u00a0NLRP3<\/strong>\u00a0Inflammasome to Induce Podocyte Injury and Mitochondrial Dysfunction.
<\/a>Zhao M, Bai M, Ding G, Zhang Y, Huang S, Jia Z, Zhang A.
Kidney Dis (Basel). 2018 Jun;4(2):83-94. doi: 10.1159\/000488242. Epub 2018 May 22.<\/p>\n

Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease.
<\/a>Farrell GC, Haczeyni F, Chitturi S.
Adv Exp Med Biol. 2018;1061:19-44. doi: 10.1007\/978-981-10-8684-7_3. Review.<\/p>\n

Anti-Inflammatory Action of Sitagliptin and Linagliptin in Doxorubicin Nephropathy.
<\/a>Jo CH, Kim S, Park JS, Kim GH.
Kidney Blood Press Res. 2018;43(3):987-999. doi: 10.1159\/000490688. Epub 2018 Jun 15.<\/p>\n

NLRP3<\/strong>: A Novel Mediator in Cardiovascular Disease.
<\/a>Zhou W, Chen C, Chen Z, Liu L, Jiang J, Wu Z, Zhao M, Chen Y.
J Immunol Res. 2018 Apr 8;2018:5702103. doi: 10.1155\/2018\/5702103. eCollection 2018. Review.<\/p>\n

Combination exposure of melamine and cyanuric acid is associated with polyuria and activation of\u00a0NLRP3<\/strong>\u00a0inflammasome in rats.
<\/a>Wang F, Liu Q, Jin L, Hu S, Luo R, Han M, Zhai Y, Wang W, Li C.
Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F199-F210. doi: 10.1152\/ajprenal.00609.2017. Epub 2018 Mar 28.<\/p>\n

Central blockade of\u00a0NLRP3<\/strong>\u00a0reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats.
<\/a>Wang ML, Kang YM, Li XG, Su Q, Li HB, Liu KL, Fu LY, Saahene RO, Li Y, Tan H, Yu XJ.
J Neuroinflammation. 2018 Mar 24;15(1):95. doi: 10.1186\/s12974-018-1131-7.<\/p>\n

Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK\/Nrf2\/HO-1 Pathway in Fructose-Fed Diabetic Rats.
<\/a>Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S.
Cardiovasc Drugs Ther. 2018 Apr;32(2):147-163. doi: 10.1007\/s10557-018-6780-3.<\/p>\n

Indoxyl Sulfate Promotes Macrophage IL-1\u03b2 Production by Activating Aryl Hydrocarbon Receptor\/NF-\u03ba\/MAPK Cascades, but the\u00a0NLRP3<\/strong>\u00a0inflammasome Was Not Activated.
<\/a>Wakamatsu T, Yamamoto S, Ito T, Sato Y, Matsuo K, Takahashi Y, Kaneko Y, Goto S, Kazama JJ, Gejyo F, Narita I.
Toxins (Basel). 2018 Mar 15;10(3). pii: E124. doi: 10.3390\/toxins10030124.<\/p>\n

RIP3-deficience attenuates potassium oxonate-induced hyperuricemia and kidney injury.
<\/a>Wang K, Hu L, Chen JK.
Biomed Pharmacother. 2018 May;101:617-626. doi: 10.1016\/j.biopha.2018.02.010. Epub 2018 Mar 22.<\/p>\n

NLRP3<\/strong>\u00a0inflammasome inhibition ameliorates tubulointerstitial injury in the remnant kidney model.
<\/a>Foresto-Neto O, \u00c1vila VF, Arias SCA, Zambom FFF, Rempel LCT, Faustino VD, Machado FG, Malheiros DMAC, Abensur H, Camara NOS, Zatz R, Fujihara CK.
Lab Invest. 2018 Jun;98(6):773-782. doi: 10.1038\/s41374-018-0029-4. Epub 2018 Mar 6.<\/p>\n

Role of Brain Neuroinflammatory Factors on\u00a0Hypertension<\/strong>\u00a0in the Spontaneously Hypertensive Rat.
<\/a>Avolio E, Pasqua T, Di Vito A, Fazzari G, Cardillo G, Al\u00f2 R, Cerra MC, Barni T, Angelone T, Canonaco M.
Neuroscience. 2018 Apr 1;375:158-168. doi: 10.1016\/j.neuroscience.2018.01.067. Epub 2018 Feb 9.<\/p>\n

The\u00a0NLRP3<\/strong>\u00a0rs10754558 polymorphism is a risk factor for preeclampsia in a Chinese Han population.
<\/a>Xu L, Li S, Liu Z, Jiang S, Wang J, Guo M, Zhao X, Song W, Liu S.
J Matern Fetal Neonatal Med. 2019 Jun;32(11):1792-1799. doi: 10.1080\/14767058.2017.1418313. Epub 2018 Jan 31.<\/p>\n

Fibronectin type III domain containing 5 attenuates\u00a0NLRP3<\/strong>\u00a0inflammasome activation and phenotypic transformation of adventitial fibroblasts in spontaneously hypertensive rats.
<\/a>Ling L, Chen D, Tong Y, Zang YH, Ren XS, Zhou H, Qi XH, Chen Q, Li YH, Kang YM, Zhu GQ.
J Hypertens. 2018 May;36(5):1104-1114. doi: 10.1097\/HJH.0000000000001654.<\/p>\n

Sirtuin 3-induced macrophage autophagy in regulating\u00a0NLRP3<\/strong>\u00a0inflammasome activation.
<\/a>Liu P, Huang G, Wei T, Gao J, Huang C, Sun M, Zhu L, Shen W.
Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):764-777. doi: 10.1016\/j.bbadis.2017.12.027. Epub 2017 Dec 20.<\/p>\n

NLRP3<\/strong>\u00a0Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular Remodeling.
<\/a>Ren XS, Tong Y, Ling L, Chen D, Sun HJ, Zhou H, Qi XH, Chen Q, Li YH, Kang YM, Zhu GQ.
Cell Physiol Biochem. 2017;44(6):2269-2280. doi: 10.1159\/000486061. Epub 2017 Dec 14.<\/p>\n

Lithium + Colchicine: A Potential Strategy to Reduce Pro-inflammatory Effects of Lithium Treatment.
<\/a>Mooney JJ, Brady RO.
J Clin Psychopharmacol. 2018 Feb;38(1):80-85. doi: 10.1097\/JCP.0000000000000830. Review.<\/p>\n

Role of\u00a0NLRP3<\/strong>\u00a0inflammasome in the pathogenesis of cardiovascular diseases.
<\/a>Liu D, Zeng X, Li X, Mehta JL, Wang X.
Basic Res Cardiol. 2017 Dec 9;113(1):5. doi: 10.1007\/s00395-017-0663-9. Print 2018 Jan 8. Review.<\/p>\n

BCL6 attenuates renal inflammation via negative regulation of\u00a0NLRP3<\/strong>\u00a0transcription.
<\/a>Cell Death Dis. 2017 Oct 26;8(10):e3156. doi: 10.1038\/cddis.2017.567.Chen D, Xiong XQ, Zang YH, Tong Y, Zhou B, Chen Q, Li YH, Gao XY, Kang YM, Zhu GQ.<\/p>\n

The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking\u00a0NLRP3<\/strong>\u00a0inflammasome activation.
<\/a>Gan W, Ren J, Li T, Lv S, Li C, Liu Z, Yang M.
Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):1-10. doi: 10.1016\/j.bbadis.2017.10.001. Epub 2017 Oct 3.<\/p>\n

NLRP3<\/strong>\u00a0inflammasome activation contributes to VSMC phenotypic transformation and proliferation in\u00a0hypertension<\/strong>.
<\/a>Sun HJ, Ren XS, Xiong XQ, Chen YZ, Zhao MX, Wang JJ, Zhou YB, Han Y, Chen Q, Li YH, Kang YM, Zhu GQ.
Cell Death Dis. 2017 Oct 5;8(10):e3074. doi: 10.1038\/cddis.2017.470.<\/p>\n

Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice.
<\/a>Sogawa Y, Nagasu H, Iwase S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Horng T, Kashihara N.
Sci Rep. 2017 Aug 18;7(1):8801. doi: 10.1038\/s41598-017-08054-2.<\/p>\n

T-lymphocyte Kv<\/sub>1.3 channel activation triggers the\u00a0NLRP3<\/strong>\u00a0inflammasome signaling pathway in hypertensive patients.
<\/a>Zhu J, Yang Y, Hu SG, Zhang QB, Yu J, Zhang YM.
Exp Ther Med. 2017 Jul;14(1):147-154. doi: 10.3892\/etm.2017.4490. Epub 2017 May 22.<\/p>\n

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress.
<\/a>Dinh QN, Drummond GR, Kemp-Harper BK, Diep H, De Silva TM, Kim HA, Vinh A, Robertson AAB, Cooper MA, Mansell A, Chrissobolis S, Sobey CG.
Aging (Albany NY). 2017 Jun 28;9(6):1595-1606. doi: 10.18632\/aging.101255.<\/p>\n

Role of P2X7<\/sub>R in the development and progression of pulmonary\u00a0hypertension<\/strong>.
<\/a>Yin J, You S, Liu H, Chen L, Zhang C, Hu H, Xue M, Cheng W, Wang Y, Li X, Shi Y, Li N, Yan S, Li X.
Respir Res. 2017 Jun 24;18(1):127. doi: 10.1186\/s12931-017-0603-0.<\/p>\n

Expression of TLR2, NOD1, and NOD2 and the\u00a0NLRP3<\/strong>\u00a0Inflammasome in Renal Tubular Epithelial Cells of Male versus Female Mice.
<\/a>DeWolf SE, Shigeoka AA, Scheinok A, Kasimsetty SG, Welch AK, McKay DB.
Nephron. 2017;137(1):68-76. doi: 10.1159\/000456016. Epub 2017 Jun 15.<\/p>\n

Innate And Adaptive Immunity are Progressively Activated in Parallel with Renal Injury in the 5\/6 Renal Ablation Model.
<\/a>Fanelli C, Arias SCA, Machado FG, Okuma JK, Malheiros DMAC, Azevedo H, Moreira-Filho CA, Camara NOS, Fujihara CK, Zatz R.
Sci Rep. 2017 Jun 9;7(1):3192. doi: 10.1038\/s41598-017-02915-6.<\/p>\n

Metabolic injury-induced\u00a0NLRP3<\/strong>\u00a0inflammasome activation dampens phospholipid degradation.
<\/a>Rampanelli E, Ors\u00f3 E, Ochodnicky P, Liebisch G, Bakker PJ, Claessen N, Butter LM, van den Bergh Weerman MA, Florquin S, Schmitz G, Leemans JC.
Sci Rep. 2017 Jun 6;7(1):2861. doi: 10.1038\/s41598-017-01994-9.<\/p>\n

Endothelial Dysfunction in Obesity.
<\/a>Engin A.
Adv Exp Med Biol. 2017;960:345-379. doi: 10.1007\/978-3-319-48382-5_15. Review.<\/p>\n

Mineralocorticoid receptor associates with pro-inflammatory bias in the hippocampus of spontaneously hypertensive rats.
<\/a>Brocca ME, Pietranera L, Meyer M, Lima A, Roig P, de Kloet ER, De Nicola AF.
J Neuroendocrinol. 2017 Jul;29(7). doi: 10.1111\/jne.12489.<\/p>\n

Metaflammation: Tissue-Specific Alterations of the\u00a0NLRP3<\/strong>\u00a0Inflammasome Platform in Metabolic Syndrome.
<\/a>Mastrocola R, Aragno M, Alloatti G, Collino M, Penna C, Pagliaro P.
Curr Med Chem. 2018;25(11):1294-1310. doi: 10.2174\/0929867324666170407123522. Review.<\/p>\n

Triptolide attenuates pressure overload-induced myocardial remodeling in mice via the inhibition of\u00a0NLRP3<\/strong>\u00a0inflammasome expression.
<\/a>Li R, Lu K, Wang Y, Chen M, Zhang F, Shen H, Yao D, Gong K, Zhang Z.
Biochem Biophys Res Commun. 2017 Mar 25;485(1):69-75. doi: 10.1016\/j.bbrc.2017.02.021. Epub 2017 Feb 12.<\/p>\n

Are the innate and adaptive immune systems setting\u00a0hypertension<\/strong>\u00a0on fire?
<\/a>Bomfim GF, Rodrigues FL, Carneiro FS.
Pharmacol Res. 2017 Mar;117:377-393. doi: 10.1016\/j.phrs.2017.01.010. Epub 2017 Jan 16. Review.<\/p>\n

NLRP3<\/strong>\u00a0inflammasome: A therapeutic option for kidney disease?
<\/a>Buelvas-Jim\u00e9nez N, Su\u00e1rez-Useche RJ, Vielma-Guevara JR.
Rev Salud Publica (Bogota). 2017 Jan-Feb;19(1):118-122. doi: 10.15446\/rsap.v19n1.54415.<\/p>\n

Intake of dietary salt and drinking water: Implications for the development of age-related macular degeneration.
<\/a>Bringmann A, Hollborn M, Kohen L, Wiedemann P.
Mol Vis. 2016 Dec 22;22:1437-1454. eCollection 2016. Review.<\/p>\n

Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice.
<\/a>Jonscher KR, Stewart MS, Alfonso-Garcia A, DeFelice BC, Wang XX, Luo Y, Levi M, Heerwagen MJ, Janssen RC, de la Houssaye BA, Wiitala E, Florey G, Jonscher RL, Potma EO, Fiehn O, Friedman JE.
FASEB J. 2017 Apr;31(4):1434-1448. doi: 10.1096\/fj.201600906R. Epub 2016 Dec 22.<\/p>\n

Suppression of\u00a0NLRP3<\/strong>\u00a0Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction.
<\/a>Bugyei-Twum A, Abadeh A, Thai K, Zhang Y, Mitchell M, Kabir G, Connelly KA.
Sci Rep. 2016 Dec 21;6:39551. doi: 10.1038\/srep39551.<\/p>\n

P2Y1 Receptor Signaling Contributes to High Salt-Induced Priming of the\u00a0NLRP3<\/strong>\u00a0Inflammasome in Retinal Pigment Epithelial Cells.
<\/a>Prager P, Hollborn M, Steffen A, Wiedemann P, Kohen L, Bringmann A.
PLoS One. 2016 Oct 27;11(10):e0165653. doi: 10.1371\/journal.pone.0165653. eCollection 2016.<\/p>\n

Deficiency of mPGES-1 exacerbates renal fibrosis and inflammation in mice with unilateral ureteral obstruction.
<\/a>Luo R, Kakizoe Y, Wang F, Fan X, Hu S, Yang T, Wang W, Li C.
Am J Physiol Renal Physiol. 2017 Jan 1;312(1):F121-F133. doi: 10.1152\/ajprenal.00231.2016. Epub 2016 Oct 26.<\/p>\n

Stabilization of endogenous Nrf2 by minocycline protects against\u00a0Nlrp3<\/strong>-inflammasome induced diabetic nephropathy.
<\/a>Shahzad K, Bock F, Al-Dabet MM, Gadi I, Nazir S, Wang H, Kohli S, Ranjan S, Mertens PR, Nawroth PP, Isermann B.
Sci Rep. 2016 Oct 10;6:34228. doi: 10.1038\/srep34228.<\/p>\n

Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated\u00a0Nlrp3<\/strong>\u00a0inflammasome activation.
<\/a>Wang L, Chen Y, Li X, Zhang Y, Gulbins E, Zhang Y.
Oncotarget. 2016 Nov 8;7(45):73229-73241. doi: 10.18632\/oncotarget.12302.<\/p>\n

Nebivolol Ameliorates Cardiac\u00a0NLRP3<\/strong>\u00a0Inflammasome Activation in a Juvenile-Adolescent Animal Model of Diet-Induced Obesity.
<\/a>Xie Q, Wei T, Huang C, Liu P, Sun M, Shen W, Gao P.
Sci Rep. 2016 Sep 30;6:34326. doi: 10.1038\/srep34326.<\/p>\n

Inflammasomes link vascular disease with neuroinflammation and brain disorders.
<\/a>L\u00e9n\u00e1rt N, Brough D, D\u00e9nes \u00c1.
J Cereb Blood Flow Metab. 2016 Oct;36(10):1668-1685. Epub 2016 Aug 2. Review.<\/p>\n

NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis.
<\/a>Zhao X, Gu C, Yan C, Zhang X, Li Y, Wang L, Ren L, Zhang Y, Peng J, Zhu Z, Han Y.
Biomed Res Int. 2016;2016:7395627. doi: 10.1155\/2016\/7395627. Epub 2016 Jun 30.<\/p>\n

Muckle-Wells Syndrome: A Case Report with an\u00a0NLRP3<\/strong>\u00a0T348M Mutation.
<\/a>Naz Villalba E, Gomez de la Fuente E, Caro Gutierrez D, Pinedo Moraleda F, Yanguela Rodilla J, Mazagatos Angulo D, L\u00f3pez Estebaranz JL.
Pediatr Dermatol. 2016 Sep;33(5):e311-4. doi: 10.1111\/pde.12905. Epub 2016 Jul 19.<\/p>\n

Oxalate, inflammasome, and progression of kidney disease.
<\/a>Ermer T, Eckardt KU, Aronson PS, Knauf F.
Curr Opin Nephrol Hypertens. 2016 Jul;25(4):363-71. doi: 10.1097\/MNH.0000000000000229. Review.<\/p>\n

NLRP3<\/strong>\u00a0deletion protects against renal fibrosis and attenuates mitochondrial abnormality in mouse with 5\/6 nephrectomy.
<\/a>Gong W, Mao S, Yu J, Song J, Jia Z, Huang S, Zhang A.
Am J Physiol Renal Physiol. 2016 May 15;310(10):F1081-8. doi: 10.1152\/ajprenal.00534.2015. Epub 2016 Feb 17.<\/p>\n

Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
<\/a>Gao Z, Han Y, Hu Y, Wu X, Wang Y, Zhang X, Fu J, Zou X, Zhang J, Chen X, Jose PA, Lu X, Zeng C.
PLoS One. 2016 Feb 11;11(2):e0149032. doi: 10.1371\/journal.pone.0149032. eCollection 2016.<\/p>\n

Thalidomide Improves the Intestinal Mucosal Injury and Suppresses Mesenteric Angiogenesis and Vasodilatation by Down-Regulating Inflammasomes-Related Cascades in Cirrhotic Rats.
<\/a>Li TH, Huang CC, Yang YY, Lee KC, Hsieh SL, Hsieh YC, Alan L, Lin HC, Lee SD, Tsai CY.
PLoS One. 2016 Jan 28;11(1):e0147212. doi: 10.1371\/journal.pone.0147212. eCollection 2016.<\/p>\n

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis.
<\/a>Mulay SR, Desai J, Kumar SV, Eberhard JN, Thomasova D, Romoli S, Grigorescu M, Kulkarni OP, Popper B, Vielhauer V, Zuchtriegel G, Reichel C, Br\u00e4sen JH, Romagnani
P, Bilyy R, Munoz LE, Herrmann M, Liapis H, Krautwald S, Linkermann A, Anders HJ.
Nat Commun. 2016 Jan 28;7:10274. doi: 10.1038\/ncomms10274.<\/p>\n

Cadmium induces\u00a0NLRP3<\/strong>\u00a0inflammasome-dependent pyroptosis in vascular endothelial cells.
<\/a><\/p>\n

Mesenchymal stem cell transplantation inhibited high salt-induced activation of the\u00a0NLRP3<\/strong>inflammasome in the renal medulla in Dahl S rats.
<\/a>Zhu Q, Li XX, Wang W, Hu J, Li PL, Conley S, Li N.
Am J Physiol Renal Physiol. 2016 Apr 1;310(7):F621-F627. doi: 10.1152\/ajprenal.00344.2015. Epub 2016 Jan 13.<\/p>\n

A Polymorphism Within the 3’UTR of\u00a0NLRP3<\/strong>\u00a0is Associated with Susceptibility for Ischemic Stroke in Chinese Population.
<\/a>Zhu Z, Yan J, Geng C, Wang D, Li C, Feng S, Wang H.
Cell Mol Neurobiol. 2016 Aug;36(6):981-988. doi: 10.1007\/s10571-015-0288-1. Epub 2015 Dec 21.<\/p>\n

Investigation on the association between\u00a0NLRP3<\/strong>\u00a0gene polymorphisms and susceptibility to primary gout.
<\/a>Wang LF, Ding YJ, Zhao Q, Zhang XL.
Genet Mol Res. 2015 Dec 9;14(4):16410-4. doi: 10.4238\/2015.December.9.10.<\/p>\n

Ischemia as a factor affecting innate immune responses in kidney transplantation.
<\/a>Kasimsetty SG, McKay DB.
Curr Opin Nephrol Hypertens. 2016 Jan;25(1):3-11. doi: 10.1097\/MNH.0000000000000190. Review.<\/p>\n

Anti-inflammatory properties of Morus bombycis Koidzumi via inhibiting IFN-\u03b2 signaling and\u00a0NLRP3<\/strong>inflammasome activation.
<\/a>Oh NH, Han JW, Shim DW, Sim EJ, Koppula S, Kwak SB, Kim MK, Kim YK, Jiang J, Park PJ, Kang TB, Lee KH.
J Ethnopharmacol. 2015 Dec 24;176:424-8. doi: 10.1016\/j.jep.2015.11.022. Epub 2015 Nov 10.<\/p>\n

NLR family pyrin domain containing 3 (NLRP3<\/strong>) inflammasome gene polymorphism rs7512998 (C>T) predicts aging-related increase of blood pressure, the TAMRISK study.
<\/a>Kunnas T, M\u00e4\u00e4tt\u00e4 K, Nikkari ST.
Immun Ageing. 2015 Oct 31;12:19. doi: 10.1186\/s12979-015-0047-7. eCollection 2015.<\/p>\n

Activation of the\u00a0NLRP3<\/strong>\u00a0inflammasome induces vascular dysfunction in obese OLETF rats.
<\/a>Liu P, Xie Q, Wei T, Chen Y, Chen H, Shen W.
Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):319-25. doi: 10.1016\/j.bbrc.2015.10.105. Epub 2015 Oct 26.<\/p>\n

NF-\u03baB Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced\u00a0Hypertension<\/strong>Through\u00a0NLRP3<\/strong>\u00a0and Caspase-1.
<\/a>Qi J, Yu XJ, Shi XL, Gao HL, Yi QY, Tan H, Fan XY, Zhang Y, Song XA, Cui W, Liu JJ, Kang YM.
Cardiovasc Toxicol. 2016 Oct;16(4):345-54. doi: 10.1007\/s12012-015-9344-9.<\/p>\n

Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease.
<\/a>Lee S, Suh GY, Ryter SW, Choi AM.
Am J Respir Cell Mol Biol. 2016 Feb;54(2):151-60. doi: 10.1165\/rcmb.2015-0231TR. Review.<\/p>\n

NLRP3<\/strong>\u00a0Deficiency Improves Angiotensin II-Induced\u00a0Hypertension<\/strong>\u00a0But Not Fetal Growth Restriction During Pregnancy.
<\/a>Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura H, Kawashima A, Ohkuchi A, Taniguchi S, Takahashi M.
Endocrinology. 2015 Nov;156(11):4281-92. doi: 10.1210\/en.2015-1408. Epub 2015 Sep 10.<\/p>\n

Targeting Interleukin-1 beta to Suppress Sympathoexcitation in Hypothalamic Paraventricular Nucleus in Dahl Salt-Sensitive Hypertensive Rats.
<\/a>Qi J, Zhao XF, Yu XJ, Yi QY, Shi XL, Tan H, Fan XY, Gao HL, Yue LY, Feng ZP, Kang YM.
Cardiovasc Toxicol. 2016 Jul;16(3):298-306. doi: 10.1007\/s12012-015-9338-7.<\/p>\n

NLRP3<\/strong>\u00a0Inflammasome Polymorphism and Macrovascular Complications in Type 2 Diabetes Patients.
<\/a>Klen J, Gori\u010dar K, Jane\u017e A, Dol\u017ean V.
J Diabetes Res. 2015;2015:616747. doi: 10.1155\/2015\/616747. Epub 2015 Jul 27.<\/p>\n

Sodium butyrate alleviates adipocyte inflammation by inhibiting\u00a0NLRP3<\/strong>\u00a0pathway.
<\/a>Wang X, He G, Peng Y, Zhong W, Wang Y, Zhang B.
Sci Rep. 2015 Aug 3;5:12676. doi: 10.1038\/srep12676.<\/p>\n

Acquired familial Mediterranean fever associated with a somatic MEFV mutation in a patient with JAK2 associated post-polycythemia myelofibrosis.
<\/a>Shinar Y, Tohami T, Livneh A, Schiby G, Hirshberg A, Nagar M, Goldstein I, Cohen R, Kukuy O, Shubman O, Sharabi Y, Gonzalez-Roca E, Arostegui JI, Rechavi G,
Amariglio N, Salomon O.
Orphanet J Rare Dis. 2015 Jun 30;10:86. doi: 10.1186\/s13023-015-0298-6.<\/p>\n

Inflammasome activity is essential for one kidney\/deoxycorticosterone acetate\/salt-induced\u00a0hypertension<\/strong>\u00a0in mice.
<\/a>Krishnan SM, Dowling JK, Ling YH, Diep H, Chan CT, Ferens D, Kett MM, Pinar A, Samuel CS, Vinh A, Arumugam TV, Hewitson TD, Kemp-Harper BK, Robertson AA, Cooper MA, Latz E, Mansell A, Sobey CG, Drummond GR.
Br J Pharmacol. 2016 Feb;173(4):752-65. doi: 10.1111\/bph.13230. Epub 2015 Jul 31.<\/p>\n

Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary\u00a0hypertension<\/strong>\u00a0in mice.
<\/a>Cero FT, Hillestad V, Sjaastad I, Yndestad A, Aukrust P, Ranheim T, Lunde IG, Olsen MB, Lien E, Zhang L, Haugstad SB, L\u00f8berg EM, Christensen G, Larsen KO, Skj\u00f8nsberg OH.
Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L378-87. doi: 10.1152\/ajplung.00342.2014. Epub 2015 Jun 12.<\/p>\n

Endogenous and Uric Acid-Induced Activation of\u00a0NLRP3<\/strong>\u00a0Inflammasome in Pregnant Women with Preeclampsia.
<\/a>Matias ML, Rom\u00e3o M, Weel IC, Ribeiro VR, Nunes PR, Borges VT, Ara\u00fajo JP Jr, Pera\u00e7oli JC, de Oliveira L, Pera\u00e7oli MT.
PLoS One. 2015 Jun 8;10(6):e0129095. doi: 10.1371\/journal.pone.0129095. eCollection 2015.<\/p>\n

[Inflammasome: activation mechanisms].
<\/a>Su\u00e1rez R, Buelvas N.
Invest Clin. 2015 Mar;56(1):74-99. Review. Spanish.\u00a0<\/p>\n

Aliskiren restores renal AQP2 expression during unilateral ureteral obstruction by inhibiting the inflammasome.
<\/a>Wang W, Luo R, Lin Y, Wang F, Zheng P, Levi M, Yang T, Li C.
Am J Physiol Renal Physiol. 2015 Apr 15;308(8):F910-22. doi: 10.1152\/ajprenal.00649.2014. Epub 2015 Feb 18.<\/p>\n

Protective effect of telmisartan on neurovascular unit and inflammasome in stroke-resistant spontaneously hypertensive rats.
<\/a>Liu W, Yamashita T, Kurata T, Kono S, Hishikawa N, Deguchi K, Zhai Y, Abe K.
Neurol Res. 2015 Jun;37(6):491-501. doi: 10.1179\/1743132815Y.0000000002. Epub 2015 Jan 16.<\/p>\n

Neurovascular protection by telmisartan via reducing neuroinflammation in stroke-resistant spontaneously hypertensive rat brain after ischemic stroke.
<\/a>Kono S, Kurata T, Sato K, Omote Y, Hishikawa N, Yamashita T, Deguchi K, Abe K.
J Stroke Cerebrovasc Dis. 2015 Mar;24(3):537-47. doi: 10.1016\/j.jstrokecerebrovasdis.2014.09.037. Epub 2014 Dec 19.<\/p>\n

Ellagic acid prevents monocrotaline-induced pulmonary artery\u00a0hypertension<\/strong>\u00a0via inhibiting\u00a0NLRP3<\/strong>inflammasome activation in rats.
<\/a>Tang B, Chen GX, Liang MY, Yao JP, Wu ZK.
Int J Cardiol. 2015 Feb 1;180:134-41. doi: 10.1016\/j.ijcard.2014.11.161. Epub 2014 Nov 25.<\/p>\n

Regulation of TLR2 and\u00a0NLRP3<\/strong>\u00a0in primary murine renal tubular epithelial cells.
<\/a>Kasimsetty SG, DeWolf SE, Shigeoka AA, McKay DB.
Nephron Clin Pract. 2014;127(1-4):119-23. doi: 10.1159\/000363208. Epub 2014 Sep 24.<\/p>\n

Losartan inhibits LPS + ATP-induced IL-1beta secretion from mouse primary macrophages by suppressing NALP3 inflammasome.
<\/a>Wang F, Huang L, Peng ZZ, Tang YT, Lu MM, Peng Y, Mel WJ, Wu L, Mo ZH, Meng J, Tao LJ.
Pharmazie. 2014 Sep;69(9):680-4.<\/p>\n

LOX-1, mtDNA damage, and\u00a0NLRP3<\/strong>\u00a0inflammasome activation in macrophages: implications in atherogenesis.
<\/a>Ding Z, Liu S, Wang X, Dai Y, Khaidakov M, Deng X, Fan Y, Xiang D, Mehta JL.
Cardiovasc Res. 2014 Sep 1;103(4):619-28. doi: 10.1093\/cvr\/cvu114. Epub 2014 Apr 28.<\/p>\n

Thioredoxin-interacting protein is required for endothelial\u00a0NLRP3<\/strong>\u00a0inflammasome activation and cell death in a rat model of high-fat diet.
<\/a>Mohamed IN, Hafez SS, Fairaq A, Ergul A, Imig JD, El-Remessy AB.
Diabetologia. 2014 Feb;57(2):413-23. doi: 10.1007\/s00125-013-3101-z. Epub 2013 Nov 8.<\/p>\n

Pirfenidone attenuates cardiac fibrosis in a mouse model of TAC-induced left ventricular remodeling by suppressing\u00a0NLRP3<\/strong>\u00a0inflammasome formation.
<\/a>Wang Y, Wu Y, Chen J, Zhao S, Li H.
Cardiology. 2013;126(1):1-11. doi: 10.1159\/000351179. Epub 2013 Jul 2.<\/p>\n

Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis.
<\/a>Shimabukuro M, Hirata Y, Tabata M, Dagvasumberel M, Sato H, Kurobe H, Fukuda D, Soeki T, Kitagawa T, Takanashi S, Sata M.
Arterioscler Thromb Vasc Biol. 2013 May;33(5):1077-84. doi: 10.1161\/ATVBAHA.112.300829. Epub 2013 Mar 7.<\/p>\n

NLRP3<\/strong>\u00a0inflammasomes show high expression in aorta of patients with atherosclerosis.
<\/a>Zheng F, Xing S, Gong Z, Xing Q.
Heart Lung Circ. 2013 Sep;22(9):746-50. doi: 10.1016\/j.hlc.2013.01.012. Epub 2013 Feb 23.<\/p>\n

Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary\u00a0hypertension<\/strong>, pulmonary vascular remodeling, and activation of the NALP3 inflammasome.
<\/a>Villegas LR, Kluck D, Field C, Oberley-Deegan RE, Woods C, Yeager ME, El Kasmi KC, Savani RC, Bowler RP, Nozik-Grayck E.
Antioxid Redox Signal. 2013 May 10;18(14):1753-64. doi: 10.1089\/ars.2012.4799. Epub 2013 Feb 5.<\/p>\n

Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia.
<\/a>Zhang C, Boini KM, Xia M, Abais JM, Li X, Liu Q, Li PL.
Hypertension<\/strong>. 2012 Jul;60(1):154-62. doi: 10.1161\/HYPERTENSIONAHA.111.189688. Epub 2012 May 29.<\/p>\n

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
<\/a>Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA.
Nature. 2012 Feb 1;482(7384):179-85. doi: 10.1038\/nature10809.<\/p>\n

Interaction of the inflammasome genes CARD8 and\u00a0NLRP3<\/strong>\u00a0in abdominal aortic aneurysms.
<\/a>Roberts RL, Van Rij AM, Phillips LV, Young S, McCormick SP, Merriman TR, Jones GT.
Atherosclerosis. 2011 Sep;218(1):123-6. doi: 10.1016\/j.atherosclerosis.2011.04.043. Epub 2011 May 10.<\/p>\n

Expression of NALP3 in the spleen of mice with portal\u00a0hypertension<\/strong>.
<\/a>Xia Z, Wang G, Wan C, Liu T, Wang S, Wang B, Cheng R.
J Huazhong Univ Sci Technolog Med Sci. 2010 Apr;30(2):170-2. doi: 10.1007\/s11596-010-0207-0. Epub 2010 Apr 21.<\/p>\n

An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and is associated with essential\u00a0hypertension<\/strong>.
<\/a>Omi T, Kumada M, Kamesaki T, Okuda H, Munkhtulga L, Yanagisawa Y, Utsumi N, Gotoh T, Hata A, Soma M, Umemura S, Ogihara T, Takahashi N, Tabara Y, Shimada K, Mano H, Kajii E, Miki T, Iwamoto S.
Eur J Hum Genet. 2006 Dec;14(12):1295-305. Epub 2006 Jul 26.<\/p>\n

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[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″] Hypertension and NLRP3 Microglia-Derived\u00a0NLRP3\u00a0Activation Mediates the Pressor Effect of Prorenin in the Rostral Ventrolateral Medulla of Stress-Induced Hypertensive RatsHu L, Zhang […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1165"}],"collection":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/comments?post=1165"}],"version-history":[{"count":3,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1165\/revisions"}],"predecessor-version":[{"id":1169,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1165\/revisions\/1169"}],"wp:attachment":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/media?parent=1165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}