{"id":1155,"date":"2020-04-15T17:52:52","date_gmt":"2020-04-15T17:52:52","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=1155"},"modified":"2020-04-15T17:54:34","modified_gmt":"2020-04-15T17:54:34","slug":"vitamin-c-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/vitamin-c-and-nlrp3\/","title":{"rendered":"Vitamin-C and NLRP3"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;3.19.3&#8243; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg&#8221; custom_padding=&#8221;0px|0px|0|0px|false|false&#8221;][et_pb_fullwidth_header title=&#8221;Are You CovidMune?&#x2122;&#8221; text_orientation=&#8221;center&#8221; _builder_version=&#8221;3.19.3&#8243; title_level=&#8221;h2&#8243; title_font=&#8221;|800|||on|||#e02b20|&#8221; title_text_color=&#8221;#ffffff&#8221; content_font=&#8221;|700|||||||&#8221; content_text_color=&#8221;#000000&#8243; subhead_font=&#8221;||||on|||#e02b20|&#8221; subhead_text_color=&#8221;#ffffff&#8221; subhead_font_size=&#8221;30px&#8221; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg&#8221; custom_button_one=&#8221;on&#8221; button_one_text_color=&#8221;#ffffff&#8221; button_one_border_color=&#8221;#e02b20&#8243; button_one_font=&#8221;|600|||||||&#8221; box_shadow_style_button_one=&#8221;preset2&#8243;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.19.3&#8243; custom_padding=&#8221;7px|0px|0|0px|false|false&#8221;][et_pb_row _builder_version=&#8221;3.19.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.19.3&#8243; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221;][et_pb_text _builder_version=&#8221;3.19.3&#8243;]<\/p>\n<h4 class=\"details\" align=\"center\"><b><u><span>Vitamin-C and NLRP3<o:p><\/o:p><\/span><\/u><\/b><\/h4>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31882076\"><span><\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30833078\">TXNIP-mediated nuclear factor-\u03baB signaling pathway and intracellular shifting of TXNIP in uric\u00a0<strong>acid<\/strong>-induced\u00a0<strong>NLRP3<\/strong>\u00a0inflammasome.<br \/><\/a>Kim SK, Choe JY, Park KY.<br \/>Biochem Biophys Res Commun. 2019 Apr 16;511(4):725-731. doi: 10.1016\/j.bbrc.2019.02.141. Epub 2019 Mar 2.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30138619\"><strong>NLRP3<\/strong>\u00a0inflammasomes and\u00a0<strong>NLRP3<\/strong>\u00a0inflammasome-derived proinflammatory cytokines in peripheral blood mononuclear cells of patients with ankylosing spondylitis.<br \/><\/a>Kim SK, Cho YJ, Choe JY.<br \/>Clin Chim Acta. 2018 Nov;486:269-274. doi: 10.1016\/j.cca.2018.08.022. Epub 2018 Aug 20.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30138321\">Effects of metal ions on caspase-1 activation and interleukin-1\u03b2 release in murine bone marrow-derived macrophages.<br \/><\/a>Ferko MA, Catelas I.<br \/>PLoS One. 2018 Aug 23;13(8):e0199936. doi: 10.1371\/journal.pone.0199936. eCollection 2018.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28326454\">Quercetin and\u00a0<strong>Ascorbic Acid<\/strong>\u00a0Suppress Fructose-Induced\u00a0<strong>NLRP3<\/strong>\u00a0Inflammasome Activation by Blocking Intracellular Shuttling of TXNIP in Human Macrophage Cell Lines.<br \/><\/a>Choe JY, Kim SK.<br \/>Inflammation. 2017 Jun;40(3):980-994. doi: 10.1007\/s10753-017-0542-4.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26454448\">Rebamipide Suppresses Monosodium Urate Crystal-Induced Interleukin-1\u03b2 Production Through Regulation of Oxidative Stress and Caspase-1 in THP-1 Cells.<br \/><\/a>Kim SK, Choe JY, Park KY.<br \/>Inflammation. 2016 Feb;39(1):473-482. doi: 10.1007\/s10753-015-0271-5.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26239883\">Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells.<br \/><\/a>Huang B, Cheng JK, Wu CY, Chen PH, Tu PS, Fu YS, Wu CH.<br \/>Vascul Pharmacol. 2017 Mar;90:27-35. doi: 10.1016\/j.vph.2015.07.014. Epub 2015 Aug 1.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26188153\">A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein.<br \/><\/a>S\u00e1nchez Vallecillo MF, Minguito de la Escalera MM, Aguirre MV, Ullio Gamboa GV, Palma SD, Gonz\u00e1lez-Cintado L, Chiodetti AL, Soldano G, Mor\u00f3n G, Allemandi DA, Ardav\u00edn C, Pistoresi-Palencia MC, Maletto BA.<br \/>J Control Release. 2015 Sep 28;214:12-22. doi: 10.1016\/j.jconrel.2015.07.008. Epub 2015 Jul 15.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p class=\"Title1\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<h4 style=\"text-align: center;\"><\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;3.19.3&#8243; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg&#8221; custom_padding=&#8221;0px|0px|0|0px|false|false&#8221;][et_pb_fullwidth_header title=&#8221;Are You CovidMune?&#x2122;&#8221; text_orientation=&#8221;center&#8221; _builder_version=&#8221;3.19.3&#8243; title_level=&#8221;h2&#8243; title_font=&#8221;|800|||on|||#e02b20|&#8221; title_text_color=&#8221;#ffffff&#8221; content_font=&#8221;|700|||||||&#8221; content_text_color=&#8221;#000000&#8243; subhead_font=&#8221;||||on|||#e02b20|&#8221; subhead_text_color=&#8221;#ffffff&#8221; subhead_font_size=&#8221;30px&#8221; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg&#8221; custom_button_one=&#8221;on&#8221; button_one_text_color=&#8221;#ffffff&#8221; button_one_border_color=&#8221;#e02b20&#8243; button_one_font=&#8221;|600|||||||&#8221; box_shadow_style_button_one=&#8221;preset2&#8243;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.19.3&#8243; custom_padding=&#8221;7px|0px|0|0px|false|false&#8221;][et_pb_row _builder_version=&#8221;3.19.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.19.3&#8243; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221;][et_pb_text _builder_version=&#8221;3.19.3&#8243;] Vitamin-C and NLRP3 TXNIP-mediated nuclear factor-\u03baB signaling pathway and intracellular shifting of TXNIP in uric\u00a0acid-induced\u00a0NLRP3\u00a0inflammasome.Kim SK, Choe JY, Park KY.Biochem Biophys [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1155"}],"collection":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/comments?post=1155"}],"version-history":[{"count":3,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1155\/revisions"}],"predecessor-version":[{"id":1159,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1155\/revisions\/1159"}],"wp:attachment":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/media?parent=1155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}