{"id":1149,"date":"2020-04-15T17:47:52","date_gmt":"2020-04-15T17:47:52","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=1149"},"modified":"2020-04-15T17:50:32","modified_gmt":"2020-04-15T17:50:32","slug":"zinc-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/zinc-and-nlrp3\/","title":{"rendered":"Zinc and NLRP3"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″]<\/p>\n

Zinc and NLRP3<\/span><\/u><\/b><\/span><\/a><\/h4>\n

Metalloimmunology: The metal ion-controlled immunity.
<\/a>Wang C, Zhang R, Wei X, Lv M, Jiang Z.
Adv Immunol. 2020;145:187-241. doi: 10.1016\/bs.ai.2019.11.007. Epub 2019 Dec 9.<\/p>\n

Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
<\/a>Yao RQ, Ren C, Xia ZF, Yao YM.
Autophagy. 2020 Feb 12:1-17. doi: 10.1080\/15548627.2020.1725377. [Epub ahead of print]<\/p>\n

Role of\u00a0zinc<\/strong>\u00a0dyshomeostasis in inflammasome formation in cultured cortical cells following lipopolysaccharide or oxygen-glucose deprivation\/reperfusion exposure.
<\/a>Park HS, Yoo MH, Koh JY.
Neurobiol Dis. 2020 Apr;137:104771. doi: 10.1016\/j.nbd.2020.104771. Epub 2020 Jan 23.<\/p>\n

Zinc<\/strong>\u00a0promotes functional recovery after spinal cord injury by activating Nrf2\/HO-1 defense pathway and inhibiting inflammation of\u00a0NLRP3<\/strong>\u00a0in nerve cells.
<\/a>Li D, Tian H, Li X, Mao L, Zhao X, Lin J, Lin S, Xu C, Liu Y, Guo Y, Mei X.
Life Sci. 2020 Mar 15;245:117351. doi: 10.1016\/j.lfs.2020.117351. Epub 2020 Jan 22.<\/p>\n

The BRCC3 regulated by Cdk5 promotes the activation of neuronal\u00a0NLRP3<\/strong>\u00a0inflammasome in Parkinson’s disease models.
<\/a>Cheng X, Xu S, Zhang C, Qin K, Yan J, Shao X.
Biochem Biophys Res Commun. 2020 Feb 12;522(3):647-654. doi: 10.1016\/j.bbrc.2019.11.141. Epub 2019 Nov 29.<\/p>\n

Emerging views of mitophagy in immunity and autoimmune diseases.
<\/a>Xu Y, Shen J, Ran Z.
Autophagy. 2020 Jan;16(1):3-17. doi: 10.1080\/15548627.2019.1603547. Epub 2019 Apr 21.<\/p>\n

TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes.
<\/a>Zhai Y, Lin P, Feng Z, Lu H, Han Q, Chen J, Zhang Y, He Q, Nan G, Luo X, Wang B, Feng F, Liu F, Chen Z, Zhu P.
Autophagy. 2018;14(9):1629-1643. doi: 10.1080\/15548627.2018.1458804. Epub 2018 Sep 1.<\/p>\n

Induction of heme oxygenas-1 attenuates\u00a0NLRP3<\/strong>\u00a0inflammasome activation in lipopolysaccharide-induced mastitis in mice.
<\/a>Xiaoyu H, Si H, Li S, Wang W, Guo J, Li Y, Cao Y, Fu Y, Zhang N.
Int Immunopharmacol. 2017 Nov;52:185-190. doi: 10.1016\/j.intimp.2017.09.007. Epub 2017 Sep 20.<\/p>\n

Reactive oxygen species trigger NF-\u03baB-mediated\u00a0NLRP3<\/strong>\u00a0inflammasome activation induced by\u00a0zinc<\/strong>oxide nanoparticles in A549 cells.
<\/a>Liang X, Zhang D, Liu W, Yan Y, Zhou F, Wu W, Yan Z.
Toxicol Ind Health. 2017 Oct;33(10):737-745. doi: 10.1177\/0748233717712409. Epub 2017 Sep 5.<\/p>\n

Zinc<\/strong>\u00a0inhibits high glucose-induced\u00a0NLRP3<\/strong>\u00a0inflammasome activation in human peritoneal mesothelial cells.
<\/a>Fan Y, Zhang X, Yang L, Wang J, Hu Y, Bian A, Liu J, Ma J.
Mol Med Rep. 2017 Oct;16(4):5195-5202. doi: 10.3892\/mmr.2017.7236. Epub 2017 Aug 11.<\/p>\n

Palmitic acid elicits hepatic stellate cell activation through inflammasomes and hedgehog signaling.
<\/a>Duan NN, Liu XJ, Wu J.
Life Sci. 2017 May 1;176:42-53. doi: 10.1016\/j.lfs.2017.03.012. Epub 2017 Mar 18.<\/p>\n

Mechanistic studies of the toxicity of\u00a0zinc<\/strong>\u00a0gluconate in the olfactory neuronal cell line Odora.
<\/a>Hsieh H, Vignesh KS, Deepe GS Jr, Choubey D, Shertzer HG, Genter MB.
Toxicol In Vitro. 2016 Sep;35:24-30. doi: 10.1016\/j.tiv.2016.05.003. Epub 2016 May 12.<\/p>\n

CdSe\/ZnS quantum dots induce hepatocyte pyroptosis and liver inflammation via\u00a0NLRP3<\/strong>inflammasome activation.
<\/a>Lu Y, Xu S, Chen H, He M, Deng Y, Cao Z, Pi H, Chen C, Li M, Ma Q, Gao P, Ji Y, Zhang L, Yu Z, Zhou Z.
Biomaterials. 2016 Jun;90:27-39. doi: 10.1016\/j.biomaterials.2016.03.003. Epub 2016 Mar 3.<\/p>\n

Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
<\/a>Gao Z, Han Y, Hu Y, Wu X, Wang Y, Zhang X, Fu J, Zou X, Zhang J, Chen X, Jose PA, Lu X, Zeng C.
PLoS One. 2016 Feb 11;11(2):e0149032. doi: 10.1371\/journal.pone.0149032. eCollection 2016.<\/p>\n

PKC\/ROS-Mediated\u00a0NLRP3<\/strong>\u00a0Inflammasome Activation Is Attenuated by Leishmania\u00a0Zinc<\/strong>-Metalloprotease during Infection.
<\/a>Shio MT, Christian JG, Jung JY, Chang KP, Olivier M.
PLoS Negl Trop Dis. 2015 Jun 26;9(6):e0003868. doi: 10.1371\/journal.pntd.0003868. eCollection 2015.<\/p>\n

Zinc<\/strong>– and oxidative property-dependent degradation of pro-caspase-1 and\u00a0NLRP3<\/strong>\u00a0by ziram in mouse macrophages.
<\/a>Muroi M, Tanamoto K.
Toxicol Lett. 2015 Jun 15;235(3):199-205. doi: 10.1016\/j.toxlet.2015.04.012. Epub 2015 Apr 27.<\/p>\n

Silver nanoparticles induce degradation of the endoplasmic reticulum stress sensor activating transcription factor-6 leading to activation of the NLRP-3 inflammasome.
<\/a>Simard JC, Vallieres F, de Liz R, Lavastre V, Girard D.
J Biol Chem. 2015 Feb 27;290(9):5926-39. doi: 10.1074\/jbc.M114.610899. Epub 2015 Jan 15.<\/p>\n

The transcription factor GFI1 negatively regulates\u00a0NLRP3<\/strong>\u00a0inflammasome activation in macrophages.
<\/a>Zhu L, Meng Q, Liang S, Ma Y, Li R, Li G, Zeng H.
FEBS Lett. 2014 Nov 28;588(23):4513-9.<\/p>\n

Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells.
<\/a>Jhang JJ, Cheng YT, Ho CY, Yen GC.
Cell Mol Immunol. 2015 Jul;12(4):424-34. doi: 10.1038\/cmi.2014.65. Epub 2014 Aug 11.<\/p>\n

Hemin inhibits\u00a0NLRP3<\/strong>\u00a0inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1.
<\/a>Luo YP, Jiang L, Kang K, Fei DS, Meng XL, Nan CC, Pan SH, Zhao MR, Zhao MY.
Int Immunopharmacol. 2014 May;20(1):24-32. doi: 10.1016\/j.intimp.2014.02.017. Epub 2014 Feb 26.<\/p>\n

Zinc<\/strong>\u00a0depletion regulates the processing and secretion of IL-1\u03b2.
<\/a>Summersgill H, England H, Lopez-Castejon G, Lawrence CB, Luheshi NM, Pahle J, Mendes P, Brough D.
Cell Death Dis. 2014 Jan 30;5:e1040. doi: 10.1038\/cddis.2013.547.<\/p>\n

NLRP3<\/strong>\u00a0inflammasome activation in D-galactosamine and lipopolysaccharide-induced acute liver failure: role of heme oxygenase-1.
<\/a>Kim SJ, Lee SM.
Free Radic Biol Med. 2013 Dec;65:997-1004. doi: 10.1016\/j.freeradbiomed.2013.08.178. Epub 2013 Aug 29.<\/p>\n

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3<\/strong>) inflammasome and cause pulmonary inflammation through release of IL-1\u03b1 and IL-1\u03b2.
<\/a>Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, Tschopp J.
<\/span>Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19449-54. doi: 10.1073\/pnas.1008155107. Epub 2010 Oct 25.<\/span><\/p>\n

<\/span><\/p>\n

<\/h4>\n

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