{"id":1134,"date":"2020-04-14T11:17:06","date_gmt":"2020-04-14T11:17:06","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=1134"},"modified":"2020-04-14T11:19:46","modified_gmt":"2020-04-14T11:19:46","slug":"asthma-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/asthma-and-nlrp3\/","title":{"rendered":"Asthma and NLRP3"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;3.19.3&#8243; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg&#8221; custom_padding=&#8221;0px|0px|0|0px|false|false&#8221;][et_pb_fullwidth_header title=&#8221;Are You CovidMune?&#x2122;&#8221; text_orientation=&#8221;center&#8221; _builder_version=&#8221;3.19.3&#8243; title_level=&#8221;h2&#8243; title_font=&#8221;|800|||on|||#e02b20|&#8221; title_text_color=&#8221;#ffffff&#8221; content_font=&#8221;|700|||||||&#8221; content_text_color=&#8221;#000000&#8243; subhead_font=&#8221;||||on|||#e02b20|&#8221; subhead_text_color=&#8221;#ffffff&#8221; subhead_font_size=&#8221;30px&#8221; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg&#8221; custom_button_one=&#8221;on&#8221; button_one_text_color=&#8221;#ffffff&#8221; button_one_border_color=&#8221;#e02b20&#8243; button_one_font=&#8221;|600|||||||&#8221; box_shadow_style_button_one=&#8221;preset2&#8243;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.19.3&#8243; custom_padding=&#8221;7px|0px|0|0px|false|false&#8221;][et_pb_row _builder_version=&#8221;3.19.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.19.3&#8243; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221;][et_pb_text _builder_version=&#8221;3.19.3&#8243;]<\/p>\n<h4 class=\"details\" align=\"center\"><b><u><span>Asthma and NLRP3<o:p><\/o:p><\/span><\/u><\/b><\/h4>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6833007\/\">Targeting\u00a0<strong>NLRP3<\/strong>\u00a0Inflammasome Activation in Severe\u00a0<strong>Asthma<br \/><\/strong><\/a>Efthymia Theofani, Maria Semitekolou, Ioannis Morianos, Konstantinos Samitas, Georgina Xanthou<br \/>J Clin Med.\u00a02019 Oct;\u00a08(10): 1615.\u00a0\u00a0Published online 2019 Oct 4.\u00a0doi:\u00a010.3390\/jcm8101615<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6290169\/\">Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory\u00a0<strong>NLRP3<\/strong>\u2013RXR axis in\u00a0<strong>asthma<br \/><\/strong><\/a>Jiajia Lv, Wen Su, Qianying Yu, Meng Zhang, Caixia Di, Xiaoliang Lin, Min Wu, Zhenwei Xia<br \/>J Biol Chem.\u00a02018 Nov 30;\u00a0293(48): 18454\u201318465.\u00a0\u00a0Published online 2018 Oct 17.\u00a0doi:\u00a010.1074\/jbc.RA118.004950<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6997282\/\">Epithelial PI3K-\u03b4 Promotes House Dust Mite-Induced Allergic\u00a0<strong>Asthma<\/strong>\u00a0in\u00a0<strong>NLRP3<\/strong>\u00a0Inflammasome-Dependent and -Independent Manners<br \/><\/a>So Ri Kim, Hae Jin Park, Kyung Bae Lee, Hee Jung Kim, Jae Seok Jeong, Seong Ho Cho, Yong Chul Lee<br \/>Allergy\u00a0<strong>Asthma<\/strong>\u00a0Immunol Res.\u00a02020 Mar;\u00a012(2): 338\u2013358.\u00a0\u00a0Published online 2020 Jan 7.\u00a0doi:\u00a010.4168\/aair.2020.12.2.338<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3873477\/\">New Insights into Mechanisms Controlling the\u00a0<strong>NLRP3<\/strong>\u00a0Inflammasome and Its Role in Lung Disease<br \/><\/a>Dominic De Nardo, Christine M. De Nardo, Eicke Latz<br \/>Am J Pathol.\u00a02014 Jan;\u00a0184(1): 42\u201354.\u00a0\u00a0doi:\u00a010.1016\/j.ajpath.2013.09.007<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7080656\/\">The Role of\u00a0<strong>NLRP3<\/strong>\u00a0Inflammasome in Radiation-Induced Cardiovascular Injury<br \/><\/a>Shanshan Huang, Jing Che, Qian Chu, Peng Zhang<br \/>Front Cell Dev Biol.\u00a02020;\u00a08: 140.\u00a0\u00a0Published online 2020 Mar 12.\u00a0doi:\u00a010.3389\/fcell.2020.00140<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6328879\/\">Estrogen ameliorates allergic airway inflammation by regulating activation of\u00a0<strong>NLRP3<\/strong>\u00a0in mice<br \/><\/a>Cheng Cheng, Huimei Wu, Muzi Wang, Lixia Wang, Hongyun Zou, Shuai Li, Rongyu Liu<br \/>Biosci Rep.\u00a02019 Jan 31;\u00a039(1): BSR20181117.\u00a0\u00a0Prepublished online 2018 Oct 29.\u00a0Published online 2019 Jan 8.\u00a0doi:\u00a010.1042\/BSR20181117<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5992571\/\">Nasal DNA methylation is associated with childhood\u00a0<strong>asthma<br \/><\/strong><\/a>Xue Zhang, Jocelyn M Biagini Myers, JD Burleson, Ashley Ulm, Kelly S Bryan, Xiaoting Chen, Matthew T Weirauch, Theresa A Baker, Melinda S Butsch Kovacic, Hong Ji<br \/>Epigenomics.\u00a02018 May;\u00a010(5): 629\u2013641.\u00a0\u00a0Published online 2018 Apr 25.\u00a0doi:\u00a010.2217\/epi-2017-0127<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5685066\/\">Vitamin D3 levels and\u00a0<strong>NLRP3<\/strong>\u00a0expression in murine models of obese\u00a0<strong>asthma<\/strong>: association with\u00a0<strong>asthma<\/strong>outcomes<br \/><\/a>J-H. Zhang, Y-P. Chen, X. Yang, C-Q. Li<br \/>Braz J Med Biol Res.\u00a02018;\u00a051(1): e6841.\u00a0\u00a0Published online 2017 Nov 13.\u00a0doi:\u00a010.1590\/1414-431X20176841<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5743824\/\"><em>Yupingfeng San<\/em>\u00a0Inhibits\u00a0<strong>NLRP3<\/strong>\u00a0Inflammasome to Attenuate the Inflammatory Response in\u00a0<strong>Asthma<\/strong>Mice<br \/><\/a>Xue Liu, Jiawen Shen, Danping Fan, Xuemei Qiu, Qingqing Guo, Kang Zheng, Hui Luo, Jun Shu, Cheng Lu, Ge Zhang, Aiping Lu, Chaoying Ma, Xiaojuan He<br \/>Front Pharmacol.\u00a02017;\u00a08: 944.\u00a0\u00a0Published online 2017 Dec 22.\u00a0doi:\u00a010.3389\/fphar.2017.00944<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5123301\/\">4th Pediatric Allergy and\u00a0<strong>Asthma<\/strong>\u00a0Meeting (PAAM)<br \/><\/a>Tolga Yavuz, <span><\/span>et, al.<br \/>Clin Transl Allergy.\u00a02016;\u00a06(Suppl 1): 1\u201360.\u00a0\u00a0Published online 2016 Nov 21.\u00a0doi:\u00a010.1186\/s13601-016-0117-8<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6614490\/\">Correlation Between the\u00a0<strong>NLRP3<\/strong>\u00a0Inflammasome and the Prognosis of Patients With LSCC<br \/><\/a>Yi Xue, Huai-Dong Du, Di Tang, Duo Zhang, Jian Zhou, Chang-Wen Zhai, Cun-Cun Yuan, Chi-Yao Hsueh, Sheng-Jie Li, Yu Heng, Lei Tao, Li-Ming Lu<br \/>Front Oncol.\u00a02019;\u00a09: 588.\u00a0\u00a0Published online 2019 Jul 2.\u00a0doi:\u00a010.3389\/fonc.2019.00588<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6240225\/\">Role of the\u00a0<strong>NLRP3<\/strong>\u00a0inflammasome in cancer<br \/><\/a>Maryam Moossavi, Negin Parsamanesh, Afsane Bahrami, Stephen L. Atkin, Amirhossein Sahebkar<br \/>Mol Cancer.\u00a02018;\u00a017: 158.\u00a0\u00a0Published online 2018 Nov 17.\u00a0doi:\u00a010.1186\/s12943-018-0900-3<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5887903\/\">Tranilast directly targets\u00a0NLRP3 to treat inflammasome\u2010driven diseases<br \/><\/a>Yi Huang, Hua Jiang, Yun Chen, Xiaqiong Wang, Yanqing Yang, Jinhui Tao, Xianming Deng, Gaolin Liang, Huafeng Zhang, Wei Jiang, Rongbin Zhou<br \/>EMBO Mol Med.\u00a02018 Apr;\u00a010(4): e8689.\u00a0\u00a0Published online 2018 Mar 12.\u00a0doi:\u00a010.15252\/emmm.201708689<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3294123\/\">Analysis of\u00a0<strong>NLRP3<\/strong>\u00a0in the Development of Allergic Airway Disease in Mice<br \/><\/a>Irving C. Allen, Corey M. Jania, Justin E. Wilson, Erin M. Tekeppe, Xiaoyang Hua, Willie J. Brickey, Mildred Kwan, Beverly H. Koller, Stephen L. Tilley, Jenny P.-Y. Ting<br \/>J Immunol.\u00a0Author manuscript; available in PMC 2013 Mar 15.<br \/>Published in final edited form as:\u00a0J Immunol. 2012 Mar 15; 188(6): 2884\u20132893.\u00a0Published online 2012 Feb 8.\u00a0doi:\u00a010.4049\/jimmunol.1102488<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6386842\/\">A Novel Insight on Endotyping Heterogeneous Severe\u00a0<strong>Asthma<\/strong>\u00a0Based on Endoplasmic Reticulum Stress: Beyond the \u201cType 2\/Non-Type 2 Dichotomy\u201d<br \/><\/a>Jae Seok Jeong, So Ri Kim, Seong Ho Cho, Yong Chul Lee<br \/>Int J Mol Sci.\u00a02019 Feb;\u00a020(3): 713.\u00a0\u00a0Published online 2019 Feb 7.\u00a0doi:\u00a010.3390\/ijms20030713<\/p>\n<p class=\"Title1\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<h4 style=\"text-align: left;\"><\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;3.19.3&#8243; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg&#8221; custom_padding=&#8221;0px|0px|0|0px|false|false&#8221;][et_pb_fullwidth_header title=&#8221;Are You CovidMune?&#x2122;&#8221; text_orientation=&#8221;center&#8221; _builder_version=&#8221;3.19.3&#8243; title_level=&#8221;h2&#8243; title_font=&#8221;|800|||on|||#e02b20|&#8221; title_text_color=&#8221;#ffffff&#8221; content_font=&#8221;|700|||||||&#8221; content_text_color=&#8221;#000000&#8243; subhead_font=&#8221;||||on|||#e02b20|&#8221; subhead_text_color=&#8221;#ffffff&#8221; subhead_font_size=&#8221;30px&#8221; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg&#8221; custom_button_one=&#8221;on&#8221; button_one_text_color=&#8221;#ffffff&#8221; button_one_border_color=&#8221;#e02b20&#8243; button_one_font=&#8221;|600|||||||&#8221; box_shadow_style_button_one=&#8221;preset2&#8243;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.19.3&#8243; custom_padding=&#8221;7px|0px|0|0px|false|false&#8221;][et_pb_row _builder_version=&#8221;3.19.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.19.3&#8243; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221;][et_pb_text _builder_version=&#8221;3.19.3&#8243;] Asthma and NLRP3 Targeting\u00a0NLRP3\u00a0Inflammasome Activation in Severe\u00a0AsthmaEfthymia Theofani, Maria Semitekolou, Ioannis Morianos, Konstantinos Samitas, Georgina XanthouJ Clin Med.\u00a02019 Oct;\u00a08(10): 1615.\u00a0\u00a0Published online [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1134"}],"collection":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/comments?post=1134"}],"version-history":[{"count":3,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1134\/revisions"}],"predecessor-version":[{"id":1138,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1134\/revisions\/1138"}],"wp:attachment":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/media?parent=1134"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}