{"id":1128,"date":"2020-04-13T14:27:02","date_gmt":"2020-04-13T14:27:02","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=1128"},"modified":"2020-04-13T14:30:01","modified_gmt":"2020-04-13T14:30:01","slug":"testosterone-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/testosterone-and-nlrp3\/","title":{"rendered":"Testosterone and NLRP3"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;3.19.3&#8243; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg&#8221; custom_padding=&#8221;0px|0px|0|0px|false|false&#8221;][et_pb_fullwidth_header title=&#8221;Are You CovidMune?&#x2122;&#8221; text_orientation=&#8221;center&#8221; _builder_version=&#8221;3.19.3&#8243; title_level=&#8221;h2&#8243; title_font=&#8221;|800|||on|||#e02b20|&#8221; title_text_color=&#8221;#ffffff&#8221; content_font=&#8221;|700|||||||&#8221; content_text_color=&#8221;#000000&#8243; subhead_font=&#8221;||||on|||#e02b20|&#8221; subhead_text_color=&#8221;#ffffff&#8221; subhead_font_size=&#8221;30px&#8221; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg&#8221; custom_button_one=&#8221;on&#8221; button_one_text_color=&#8221;#ffffff&#8221; button_one_border_color=&#8221;#e02b20&#8243; button_one_font=&#8221;|600|||||||&#8221; box_shadow_style_button_one=&#8221;preset2&#8243;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.19.3&#8243; custom_padding=&#8221;7px|0px|0|0px|false|false&#8221;][et_pb_row _builder_version=&#8221;3.19.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.19.3&#8243; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221;][et_pb_text _builder_version=&#8221;3.19.3&#8243;]<\/p>\n<h4 class=\"details\" align=\"center\"><b><u><span>Testosterone and NLRP3<\/p>\n<p><o:p><\/o:p><\/span><\/u><\/b><\/h4>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32197947\">Sex differences in inflammation, redox biology, mitochondria and autoimmunity.<br \/><\/a>Di Florio DN, Sin J, Coronado MJ, Atwal PS, Fairweather D.<br \/>Redox Biol. 2020 Mar 4:101482. doi: 10.1016\/j.redox.2020.101482. [Epub ahead of print] Review.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32182125\">Androgen aggravates liver fibrosis by activation of\u00a0<strong>NLRP3<\/strong>\u00a0inflammasome in CCl<sub>4<\/sub>\u00a0induced liver injury mouse model.<br \/><\/a>Ma X, Zhou Y, Qiao B, Jiang S, Shen Q, Han Y, Liu A, Chen X, Wei L, Zhou L, Zhao J.<br \/>Am J Physiol Endocrinol Metab. 2020 Mar 17. doi: 10.1152\/ajpendo.00427.2019. [Epub ahead of print]<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31474981\">Activation of the\u00a0<strong>NLRP3<\/strong>\u00a0Inflammasome Pathway by Prokineticin 2 in Testicular Macrophages of Uropathogenic\u00a0<em>Escherichia coli<\/em>&#8211; Induced Orchitis.<br \/><\/a>Li Y, Su Y, Zhou T, Hu Z, Wei J, Wang W, Liu C, Zhang H, Zhao K.<br \/>Front Immunol. 2019 Aug 14;10:1872. doi: 10.3389\/fimmu.2019.01872. eCollection 2019.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31401744\">Diacerein Downregulates\u00a0<strong>NLRP3<\/strong>\/Caspase-1\/IL-1\u03b2 and IL-6\/STAT3 Pathways of Inflammation and Apoptosis in a Rat Model of Cadmium Testicular Toxicity.<br \/><\/a>Fouad AA, Abdel-Aziz AM, Hamouda AAH.<br \/>Biol Trace Elem Res. 2019 Aug 10. doi: 10.1007\/s12011-019-01865-6. [Epub ahead of print]<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31222000\">Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis.<br \/><\/a>Li MY, Zhu XL, Zhao BX, Shi L, Wang W, Hu W, Qin SL, Chen BH, Zhou PH, Qiu B, Gao Y, Liu BL.<br \/>Cell Death Dis. 2019 Jun 20;10(7):489. doi: 10.1038\/s41419-019-1728-5.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30476817\">PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183\/96\/182 cluster targeting FOXO1 in mouse.<br \/><\/a>Zhou L, Su X, Li B, Chu C, Sun H, Zhang N, Han B, Li C, Zou B, Niu Y, Zhang R.<br \/>Ecotoxicol Environ Saf. 2019 Mar;169:551-563. doi: 10.1016\/j.ecoenv.2018.10.108. Epub 2018 Nov 24.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22512814\">Muckle-Wells syndrome and male hypofertility: a case series.<br \/><\/a>Tran TA, Kon\u00e9-Paut I, Marie I, Ninet J, Cuisset L, Meinzer U.<br \/>Semin Arthritis Rheum. 2012 Dec;42(3):327-31. doi: 10.1016\/j.semarthrit.2012.03.005. Epub 2012 Apr 17.<\/p>\n<p>&nbsp;<\/p>\n<p class=\"Title1\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<h4 style=\"text-align: center;\"><\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;3.19.3&#8243; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg&#8221; custom_padding=&#8221;0px|0px|0|0px|false|false&#8221;][et_pb_fullwidth_header title=&#8221;Are You CovidMune?&#x2122;&#8221; text_orientation=&#8221;center&#8221; _builder_version=&#8221;3.19.3&#8243; title_level=&#8221;h2&#8243; title_font=&#8221;|800|||on|||#e02b20|&#8221; title_text_color=&#8221;#ffffff&#8221; content_font=&#8221;|700|||||||&#8221; content_text_color=&#8221;#000000&#8243; subhead_font=&#8221;||||on|||#e02b20|&#8221; subhead_text_color=&#8221;#ffffff&#8221; subhead_font_size=&#8221;30px&#8221; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg&#8221; custom_button_one=&#8221;on&#8221; button_one_text_color=&#8221;#ffffff&#8221; button_one_border_color=&#8221;#e02b20&#8243; button_one_font=&#8221;|600|||||||&#8221; box_shadow_style_button_one=&#8221;preset2&#8243;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.19.3&#8243; custom_padding=&#8221;7px|0px|0|0px|false|false&#8221;][et_pb_row _builder_version=&#8221;3.19.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.19.3&#8243; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221;][et_pb_text _builder_version=&#8221;3.19.3&#8243;] Testosterone and NLRP3 Sex differences in inflammation, redox biology, mitochondria and autoimmunity.Di Florio DN, Sin J, Coronado MJ, Atwal PS, Fairweather [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1128"}],"collection":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/comments?post=1128"}],"version-history":[{"count":3,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1128\/revisions"}],"predecessor-version":[{"id":1132,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1128\/revisions\/1132"}],"wp:attachment":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/media?parent=1128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}