{"id":1122,"date":"2020-04-13T14:15:43","date_gmt":"2020-04-13T14:15:43","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=1122"},"modified":"2020-04-13T14:24:45","modified_gmt":"2020-04-13T14:24:45","slug":"estrogen-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/estrogen-and-nlrp3\/","title":{"rendered":"Estrogen and NLRP3"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″]<\/p>\n

Estrogen and NLRP3
<\/span><\/u><\/b><\/span><\/a>
<\/span><\/u><\/b><\/h4>\n

Sex differences in inflammation, redox biology, mitochondria and autoimmunity.
<\/a>Di Florio DN, Sin J, Coronado MJ, Atwal PS, Fairweather D.
Redox Biol. 2020 Mar 4:101482. doi: 10.1016\/j.redox.2020.101482. [Epub ahead of print] Review.<\/p>\n

Estrogen<\/strong>\u00a0deficiency aggravates apical periodontitis by regulating\u00a0NLRP3<\/strong>\/caspase-1\/IL-1\u03b2 axis.
<\/a>Guan X, Guan Y, Shi C, Zhu X, He Y, Wei Z, Yang J, Hou T.
Am J Transl Res. 2020 Feb 15;12(2):660-671. eCollection 2020.<\/p>\n

G-protein-coupled\u00a0estrogen<\/strong>\u00a0receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense.
<\/a>Bai N, Zhang Q, Zhang W, Liu B, Yang F, Brann D, Wang R.
<\/span>J Neuroinflammation. 2020 Feb 1;17(1):45. doi: 10.1186\/s12974-020-1715-x.<\/span><\/p>\n

Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as new classes of\u00a0NLRP3<\/strong>inflammasome inhibitors via ER-\u03b2 structure based virtual screening.
<\/a>Abdullaha M, Ali M, Kour D, Kumar A, Bharate SB.
<\/span>Bioorg Chem. 2020 Jan;95:103500. doi: 10.1016\/j.bioorg.2019.103500. Epub 2019 Dec 9.<\/span><\/p>\n

Biochanin A attenuates myocardial ischemia\/reperfusion injury through the TLR4\/NF-\u03baB\/NLRP3<\/strong>signaling pathway.
<\/a>Bai Y, Li Z, Liu W, Gao D, Liu M, Zhang P.
<\/span>Acta Cir Bras. 2019 Dec 20;34(11):e201901104. doi: 10.1590\/s0102-865020190110000004. eCollection 2019.<\/span><\/p>\n

Biochanin A protects against angiotensin II-induced damage of dopaminergic neurons in rats associated with the increased endophilin A2 expression.
<\/a>Xue HX, Kong H, Yu YG, Zhou JW, Chen HQ, Yin YY.
<\/span>Behav Pharmacol. 2019 Dec;30(8):700-711. doi: 10.1097\/FBP.0000000000000515.<\/span><\/p>\n

NLRP3<\/strong>\u00a0inflammasome activation by\u00a0estrogen<\/strong>\u00a0promotes the progression of human endometrial cancer.
<\/a>Liu SG, Wu XX, Hua T, Xin XY, Feng DL, Chi SQ, Wang XX, Wang HB.
<\/span>Onco Targets Ther. 2019 Aug 27;12:6927-6936. doi: 10.2147\/OTT.S218240. eCollection 2019.<\/span><\/p>\n

Tamoxifen-induced, intestinal-specific deletion of\u00a0Slc5a6<\/em>\u00a0in adult mice leads to spontaneous inflammation: involvement of NF-\u03baB,\u00a0NLRP3<\/strong>, and gut microbiota.
<\/a>Sabui S, Skupsky J, Kapadia R, Cogburn K, Lambrecht NW, Agrawal A, Said HM.
<\/span>Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G518-G530. doi: 10.1152\/ajpgi.00172.2019. Epub 2019 Aug 1.<\/span><\/p>\n

Estrogen<\/strong>\u00a0receptor alpha regulates the Wnt\/\u03b2-catenin signaling pathway in colon cancer by targeting the NOD-like receptors.
<\/a>Liu S, Fan W, Gao X, Huang K, Ding C, Ma G, Yan L, Song S.
<\/span>Cell Signal. 2019 Sep;61:86-92. doi: 10.1016\/j.cellsig.2019.05.009. Epub 2019 May 20.<\/span><\/p>\n

NLRP3<\/strong>\u00a0inhibition improves heart function in GPER knockout mice.
<\/a>Wang H, Sun X, Hodge HS, Ferrario CM, Groban L.
<\/span>Biochem Biophys Res Commun. 2019 Jun 30;514(3):998-1003. doi: 10.1016\/j.bbrc.2019.05.045. Epub 2019 May 12.<\/span><\/p>\n

Mono-(2-ethylhexyl) Phthalate Aggravates Inflammatory Response via Sirtuin Regulation and Inflammasome Activation in RAW 264.7 Cells.
<\/a>Park MH, Guti\u00e9rrez-Garc\u00eda AK, Choudhury M.
<\/span>Chem Res Toxicol. 2019 May 20;32(5):935-942. doi: 10.1021\/acs.chemrestox.9b00101. Epub 2019 May 8.<\/span><\/p>\n

E2-Induced Activation of the\u00a0NLRP3<\/strong>\u00a0Inflammasome Triggers Pyroptosis and Inhibits Autophagy in HCC Cells.
<\/a>Wei Q, Zhu R, Zhu J, Zhao R, Li M.
<\/span>Oncol Res. 2019 Jul 12;27(7):827-834. doi: 10.3727\/096504018X15462920753012. Epub 2019 Mar 25.<\/span><\/p>\n

Extrinsic and intrinsic apoptosis activate pannexin-1 to drive\u00a0NLRP3<\/strong>\u00a0inflammasome assembly.
<\/a>Chen KW, Demarco B, Heilig R, Shkarina K, Boettcher A, Farady CJ, Pelczar P, Broz P.
<\/span>EMBO J. 2019 May 15;38(10). pii: e101638. doi: 10.15252\/embj.2019101638. Epub 2019 Mar 22.<\/span><\/p>\n

Genistein protects against DSS-induced colitis by inhibiting\u00a0NLRP3<\/strong><\/a><\/p>\n

\u00a0inflammasome via TGR5-cAMP signaling.<\/a>Chen Y, Le TH, Du Q, Zhao Z, Liu Y, Zou J, Hua W, Liu C, Zhu Y.
<\/span>Int Immunopharmacol. 2019 Jun;71:144-154. doi: 10.1016\/j.intimp.2019.01.021. Epub 2019 Mar 19.<\/span><\/p>\n

Estrogen<\/strong>\u00a0receptors participate in carcinogenesis signaling pathways by directly regulating NOD-like receptors.
<\/a>Fan W, Gao X, Ding C, Lv Y, Shen T, Ma G, Yan L, Song S.
<\/span>Biochem Biophys Res Commun. 2019 Apr 2;511(2):468-475. doi: 10.1016\/j.bbrc.2019.02.085. Epub 2019 Feb 21.<\/span><\/p>\n

Growth of breast cancer cells by leptin is mediated via activation of the inflammasome: Critical roles of\u00a0estrogen<\/strong><\/a><\/p>\n

\u00a0receptor signaling and reactive oxygen species production.<\/a>Raut PK, Kim SH, Choi DY, Jeong GS, Park PH.
<\/span>Biochem Pharmacol. 2019 Mar;161:73-88. doi: 10.1016\/j.bcp.2019.01.006. Epub 2019 Jan 10.<\/span><\/p>\n

GEN-27 exhibits anti-inflammatory effects by suppressing the activation of\u00a0NLRP3<\/strong>\u00a0inflammasome and NF-\u03baB pathway.
<\/a>Hu M, Li X, Zhang J, Yuan Z, Fu Y, Ma X, Ren N.
<\/span>Cell Biol Int. 2019 Oct;43(10):1184-1192. doi: 10.1002\/cbin.11101. Epub 2019 Aug 4.<\/span><\/p>\n

Resveratrol ameliorates\u00a0estrogen<\/strong>\u00a0deficiency-induced depression- and anxiety-like behaviors and hippocampal inflammation in mice.
<\/a>Liu T, Ma Y, Zhang R, Zhong H, Wang L, Zhao J, Yang L, Fan X.
<\/span>Psychopharmacology (Berl). 2019 Apr;236(4):1385-1399. doi: 10.1007\/s00213-018-5148-5. Epub 2019 Jan 4.<\/span><\/p>\n

Rapamycin\u2011induced autophagy attenuates hormone\u2011imbalance\u2011induced chronic non\u2011bacterial prostatitis in rats via the inhibition of\u00a0NLRP3<\/strong>\u00a0inflammasome\u2011mediated inflammation.
<\/a>Lu J, Su Y, Chen X, Chen Y, Luo P, Lin F, Zhang J.
<\/span>Mol Med Rep. 2019 Jan;19(1):221-230. doi: 10.3892\/mmr.2018.9683. Epub 2018 Nov 21.<\/span><\/p>\n

Estrogen<\/strong>\u00a0ameliorates allergic airway inflammation by regulating activation of\u00a0NLRP3<\/strong>\u00a0in mice.
<\/a>Cheng C, Wu H, Wang M, Wang L, Zou H, Li S, Liu R.
<\/span>Biosci Rep. 2019 Jan 8;39(1). pii: BSR20181117. doi: 10.1042\/BSR20181117. Print 2019 Jan 31.<\/span><\/p>\n

Zearalenone can relieve dextran sulfate sodium-induced inflammatory reaction.
<\/a>Ding C, Fan W, Shen T, Huang K, Song S, Yan L.
<\/span>J Biochem Mol Toxicol. 2018 Oct 1:e22236. doi: 10.1002\/jbt.22236. [Epub ahead of print]<\/span><\/p>\n

NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice.
<\/a>Inzaugarat ME, Johnson CD, Holtmann TM, McGeough MD, Trautwein C, Papouchado BG, Schwabe R, Hoffman HM, Wree A, Feldstein AE.
<\/span>Hepatology. 2019 Feb;69(2):845-859. doi: 10.1002\/hep.30252. Epub 2019 Jan 3.<\/span><\/p>\n

The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice.
<\/a>Wang J, Wang L, Zhou J, Qin A, Chen Z.
<\/span>Biomed Pharmacother. 2018 Oct;106:1250-1257. doi: 10.1016\/j.biopha.2018.07.063. Epub 2018 Jul 20.<\/span><\/p>\n

Effect of Estradiol in an Azoxymethane\/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development.
<\/a>Son HJ, Sohn SH, Kim N, Lee HN, Lee SM, Nam RH, Park JH, Song CH, Shin E, Na HY, Kim JS, Lee DH, Surh YJ.
<\/span>Cancer Res Treat. 2019 Apr;51(2):632-648. doi: 10.4143\/crt.2018.060. Epub 2018 Aug 1.<\/span><\/p>\n

17\u03b2<\/em>-Estradiol Regulates Microglia Activation and Polarization in the Hippocampus Following Global Cerebral Ischemia.
<\/a>Thakkar R, Wang R, Wang J, Vadlamudi RK, Brann DW.
<\/span>Oxid Med Cell Longev. 2018 Apr 18;2018:4248526. doi: 10.1155\/2018\/4248526. eCollection 2018.<\/span><\/p>\n

Melatonin Suppresses\u00a0Estrogen<\/strong>\u00a0Deficiency-Induced Osteoporosis and Promotes Osteoblastogenesis by Inactivating the\u00a0NLRP3<\/strong>\u00a0Inflammasome.
<\/a>Xu L, Zhang L, Wang Z, Li C, Li S, Li L, Fan Q, Zheng L.
<\/span>Calcif Tissue Int. 2018 Oct;103(4):400-410. doi: 10.1007\/s00223-018-0428-y. Epub 2018 May 26.<\/span><\/p>\n

Impact of steroid hormones E2 and P on the\u00a0NLRP3<\/strong>\/ASC\/Casp1 axis in primary mouse astroglia and BV-2 cells after in vitro hypoxia.
<\/a>Slowik A, Lammerding L, Zendedel A, Habib P, Beyer C.
<\/span>J Steroid Biochem Mol Biol. 2018 Oct;183:18-26. doi: 10.1016\/j.jsbmb.2018.05.003. Epub 2018 May 15.<\/span><\/p>\n

Chronic Amyloid \u03b2 Oligomer Infusion Evokes Sustained Inflammation and Microglial Changes in the Rat Hippocampus via\u00a0NLRP3<\/strong>.
<\/a>Fekete C, Vastagh C, D\u00e9nes \u00c1, Hrabovszky E, Nyiri G, Kall\u00f3 I, Liposits Z, S\u00e1rv\u00e1ri M.
<\/span>Neuroscience. 2019 May 1;405:35-46. doi: 10.1016\/j.neuroscience.2018.02.046. Epub 2018 Mar 6.<\/span><\/p>\n

Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting\u00a0NLRP3<\/strong>\u00a0Inflammasome Signaling Pathway.
<\/a>Wu D, Wu K, Zhu Q, Xiao W, Shan Q, Yan Z, Wu J, Deng B, Xue Y, Gong W, Lu G, Ding Y.
<\/span>Mediators Inflamm. 2018 Jan 8;2018:3048532. doi: 10.1155\/2018\/3048532. eCollection 2018. Erratum in:\u00a0<\/span>Mediators Inflamm. 2018 Sep 6;2018:9878120<\/a>.\u00a0<\/span><\/p>\n

Estradiol inhibits\u00a0NLRP3<\/strong>\u00a0inflammasome in fibroblast-like synoviocytes activated by lipopolysaccharide and adenosine triphosphate.
<\/a>Shi J, Zhao W, Ying H, Zhang Y, Du J, Chen S, Li J, Shen B.
<\/span>Int J Rheum Dis. 2018 Nov;21(11):2002-2010. doi: 10.1111\/1756-185X.13198. Epub 2017 Nov 3.<\/span><\/p>\n

Zearalenone (ZEA)-induced intestinal inflammation is mediated by the\u00a0NLRP3<\/strong>\u00a0inflammasome.
<\/a>Fan W, Lv Y, Ren S, Shao M, Shen T, Huang K, Zhou J, Yan L, Song S.
<\/span>Chemosphere. 2018 Jan;190:272-279. doi: 10.1016\/j.chemosphere.2017.09.145. Epub 2017 Sep 30.<\/span><\/p>\n

X-11-5-27, a daidzein derivative, inhibits\u00a0NLRP3<\/strong>\u00a0inflammasome activity via promoting autophagy.
<\/a>Zhou W, Liu X, Cheng K, Zhang X, Lu J, Hu R.
<\/span>Exp Cell Res. 2017 Nov 15;360(2):320-327. doi: 10.1016\/j.yexcr.2017.09.022. Epub 2017 Sep 20.<\/span><\/p>\n

Bone matrix components activate the\u00a0NLRP3<\/strong>\u00a0inflammasome and promote osteoclast differentiation.
<\/a>Alippe Y, Wang C, Ricci B, Xiao J, Qu C, Zou W, Novack DV, Abu-Amer Y, Civitelli R, Mbalaviele G.
<\/span>Sci Rep. 2017 Jul 26;7(1):6630. doi: 10.1038\/s41598-017-07014-0.<\/span><\/p>\n

Estrogen<\/strong>\u00a0Attenuates Local Inflammasome Expression and Activation after Spinal Cord Injury.
<\/a>Zendedel A, M\u00f6nnink F, Hassanzadeh G, Zaminy A, Ansar MM, Habib P, Slowik A, Kipp M, Beyer C.
<\/span>Mol Neurobiol. 2018 Feb;55(2):1364-1375. doi: 10.1007\/s12035-017-0400-2. Epub 2017 Jan 27.<\/span><\/p>\n

Administration of 17\u03b2-Estradiol Improves Motoneuron Survival and Down-regulates Inflammasome Activation in Male SOD1(G93A) ALS Mice.
<\/a>Heitzer M, Kaiser S, Kanagaratnam M, Zendedel A, Hartmann P, Beyer C, Johann S.
<\/span>Mol Neurobiol. 2017 Dec;54(10):8429-8443. doi: 10.1007\/s12035-016-0322-4. Epub 2016 Dec 12. Erratum in:\u00a0<\/span>Mol Neurobiol. 2017 Jan 19;:<\/a>.\u00a0<\/span><\/p>\n

NLRP3<\/strong>\u00a0Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17\u03b2<\/em>-Estradiol.
<\/a>Thakkar R, Wang R, Sareddy G, Wang J, Thiruvaiyaru D, Vadlamudi R, Zhang Q, Brann D.
<\/span>Oxid Med Cell Longev. 2016;2016:8309031. Epub 2016 Oct 23.<\/span><\/p>\n

IL-18BP is decreased in osteoporotic women: Prevents Inflammasome mediated IL-18 activation and reduces Th17 differentiation.
<\/a>Mansoori MN, Shukla P, Kakaji M, Tyagi AM, Srivastava K, Shukla M, Dixit M, Kureel J, Gupta S, Singh D.
<\/span>Sci Rep. 2016 Sep 21;6:33680. doi: 10.1038\/srep33680.<\/span><\/p>\n

Ameliorative effect of dietary genistein on diabetes induced hyper-inflammation and oxidative stress during early stage of wound healing in alloxan induced diabetic mice.
<\/a>Eo H, Lee HJ, Lim Y.
<\/span>Biochem Biophys Res Commun. 2016 Sep 23;478(3):1021-7. doi: 10.1016\/j.bbrc.2016.07.039. Epub 2016 Jul 16.<\/span><\/p>\n

Biochanin A protects lipopolysaccharide\/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting\u00a0NLRP3<\/strong>\u00a0inflammasome activation.
<\/a>Liu X, Wang T, Liu X, Cai L, Qi J, Zhang P, Li Y.
<\/span>Int Immunopharmacol. 2016 Sep;38:324-31. doi: 10.1016\/j.intimp.2016.06.009. Epub 2016 Jun 23.<\/span><\/p>\n

Exercise amelioration of depression-like behavior in OVX mice is associated with suppression of\u00a0NLRP3<\/strong>\u00a0inflammasome activation in hippocampus.
<\/a>Wang Y, Xu Y, Sheng H, Ni X, Lu J.
<\/span>Behav Brain Res. 2016 Jul 1;307:18-24. doi: 10.1016\/j.bbr.2016.03.044. Epub 2016 Mar 29.<\/span><\/p>\n

NLRP3<\/strong>\u00a0inflammasome activation mediates\u00a0estrogen<\/strong>\u00a0deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice.
<\/a>Xu Y, Sheng H, Bao Q, Wang Y, Lu J, Ni X.
<\/span>Brain Behav Immun. 2016 Aug;56:175-86. doi: 10.1016\/j.bbi.2016.02.022. Epub 2016 Feb 27.<\/span><\/p>\n

Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain.
<\/a>Lammerding L, Slowik A, Johann S, Beyer C, Zendedel A.
<\/span>Neuroendocrinology. 2016;103(5):460-75. doi: 10.1159\/000439435. Epub 2015 Aug 25.<\/span><\/p>\n

Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells.
<\/a>Panchanathan R, Liu H, Leung YK, Ho SM, Choubey D.
<\/span>Mol Cell Endocrinol. 2015 Nov 5;415:45-55. doi: 10.1016\/j.mce.2015.08.003. Epub 2015 Aug 12.<\/span><\/p>\n

17\u03b2-Estradiol transcriptionally modulates Nlrp1 and\u00a0Nlrp3<\/strong>\u00a0inflammasomes in gonadectomized rats with inflammation.
<\/a>G\u00f3mez L\u00f3pez M, Dom\u00ednguez L\u00f3pez A, Abarca Rojano E, Rojas Hern\u00e1ndez S, Mart\u00ednez God\u00ednez Mde L, Miliar Garc\u00eda A, Campos Rodr\u00edguez R.
<\/span>Immunopharmacol Immunotoxicol. 2015;37(4):343-50. doi: 10.3109\/08923973.2015.1059439. Epub 2015 Jul 8.<\/span><\/p>\n

Estrogen<\/strong>\u00a0suppresses hepatocellular carcinoma cells through ER\u03b2-mediated upregulation of the\u00a0NLRP3<\/strong>\u00a0inflammasome.
<\/a>Wei Q, Guo P, Mu K, Zhang Y, Zhao W, Huai W, Qiu Y, Li T, Ma X, Liu Y, Chen X, Han L.
<\/span>Lab Invest. 2015 Jul;95(7):804-16. doi: 10.1038\/labinvest.2015.63. Epub 2015 May 25.<\/span><\/p>\n

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