{"id":1085,"date":"2020-04-11T23:28:57","date_gmt":"2020-04-11T23:28:57","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=1085"},"modified":"2020-04-11T23:33:26","modified_gmt":"2020-04-11T23:33:26","slug":"adenosine-analogues-remdesivir-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/adenosine-analogues-remdesivir-and-nlrp3\/","title":{"rendered":"Adenosine Analogues (Remdesivir) and NLRP3"},"content":{"rendered":"

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Adenosine Analogues (Remdesivir) and NLRP3<\/o:p><\/span><\/u><\/b><\/h4>\n

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GEN-27 exhibits anti-inflammatory effects by suppressing the activation of\u00a0NLRP3<\/strong>\u00a0inflammasome and NF-\u03baB pathway.
<\/a>Hu M, Li X, Zhang J, Yuan Z, Fu Y, Ma X, Ren N.
Cell Biol Int. 2019 Oct;43(10):1184-1192. doi: 10.1002\/cbin.11101. Epub 2019 Aug 4.<\/p>\n

Structural Moieties Required for Cinnamaldehyde-Related Compounds to Inhibit Canonical IL-1\u03b2 Secretion.
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Molecules. 2018 Dec 7;23(12). pii: E3241. doi: 10.3390\/molecules23123241.<\/p>\n

P2X7<\/sub>\u00a0receptor inhibition attenuated sympathetic nerve sprouting after myocardial infarction via the\u00a0NLRP3<\/strong>\/IL-1\u03b2 pathway.
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J Cell Mol Med. 2017 Nov;21(11):2695-2710. doi: 10.1111\/jcmm.13185. Epub 2017 May 4.<\/p>\n

Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of\u00a0NLRP3<\/strong>\u00a0inflammasome activation and NF-\u03baB signaling.
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Oncotarget. 2017 May 9;8(19):31023-31040. doi: 10.18632\/oncotarget.16052.<\/p>\n

Synthesis\u00a0and\u00a0Biological\u00a0Evaluation\u00a0of\u00a0Novel Benzimidazole\u00a0Derivatives\u00a0and\u00a0Analogs<\/strong>Targeting\u00a0the\u00a0NLRP3<\/strong>\u00a0Inflammasome.
<\/a>Pan L, Hang N, Zhang C, Chen Y, Li S, Sun Y, Li Z, Meng X.
Molecules. 2017 Jan 30;22(2). pii: E213. doi: 10.3390\/molecules22020213.<\/p>\n

Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via\u00a0Adenosine<\/strong>.
<\/a>Birnbaum Y, Birnbaum GD, Birnbaum I, Nylander S, Ye Y.
Cardiovasc Drugs Ther. 2016 Dec;30(6):539-550.<\/p>\n

Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1\u03b2 Release.
<\/a>Hecker A, K\u00fcllmar M, Wilker S, Richter K, Zakrzewicz A, Atanasova S, Mathes V, Timm T, Lerner S, Klein J, Kaufmann A, Bauer S, Padberg W, Kummer W, Janciauskiene S, Fronius M, Schweda EK, Lochnit G, Grau V.
J Immunol. 2015 Sep 1;195(5):2325-34. doi: 10.4049\/jimmunol.1400974. Epub 2015 Jul 22.<\/p>\n

K+ efflux agonists induce\u00a0NLRP3<\/strong>\u00a0inflammasome activation independently of Ca2+ signaling.
<\/a>Katsnelson MA, Rucker LG, Russo HM, Dubyak GR.
J Immunol. 2015 Apr 15;194(8):3937-52. doi: 10.4049\/jimmunol.1402658. Epub 2015 Mar 11.<\/p>\n

The P2X7 receptor directly interacts with the\u00a0NLRP3<\/strong>\u00a0inflammasome scaffold protein.
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FASEB J. 2015 Jun;29(6):2450-61. doi: 10.1096\/fj.14-268714. Epub 2015 Feb 17.<\/span><\/p>\n

Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the\u00a0adenosine<\/strong>\u00a0triphosphate-induced cytokine release from macrophages.
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Polyenylpyrrole derivatives inhibit\u00a0NLRP3<\/strong>\u00a0inflammasome activation and inflammatory mediator expression by reducing reactive oxygen species production and mitogen-activated protein kinase activation.
<\/a>Hua KF, Chou JC, Lam Y, Tasi YL, Chen A, Ka SM, Fang Z, Liu ML, Yang FL, Yang YL, Chiu YC, Wu SH.
<\/span>PLoS One. 2013 Oct 7;8(10):e76754. doi: 10.1371\/journal.pone.0076754. eCollection 2013.<\/span><\/p>\n

P2X7R\/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH.
<\/a>Chen S, Ma Q, Krafft PR, Hu Q, Rolland W 2nd, Sherchan P, Zhang J, Tang J, Zhang JH.
<\/span>Neurobiol Dis. 2013 Oct;58:296-307. doi: 10.1016\/j.nbd.2013.06.011. Epub 2013 Jun 29.<\/span><\/p>\n

Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis.
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Metabolic stress boosts humoral responses in vivo independently of inflammasome and inflammatory reaction.
<\/a>Andris F, Denanglaire S, Baus E, Rongvaux A, Steuve J, Flavell RA, Leo O.
<\/span>J Immunol. 2011 Feb 15;186(4):2245-53. doi: 10.4049\/jimmunol.1002333. Epub 2011 Jan 19.<\/span><\/p>\n

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