{"id":1079,"date":"2020-04-11T23:19:13","date_gmt":"2020-04-11T23:19:13","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=1079"},"modified":"2020-04-11T23:23:10","modified_gmt":"2020-04-11T23:23:10","slug":"vitamin-d-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/vitamin-d-and-nlrp3\/","title":{"rendered":"Vitamin D and NLRP3"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″]<\/p>\n

Vitamin D and NLRP3<\/span><\/u><\/b><\/h4>\n

 <\/p>\n

1,25(OH)2<\/sub>\u00a0D3<\/sub>\u00a0alleviates DSS-induced ulcerative colitis via inhibiting\u00a0NLRP3<\/strong>\u00a0inflammasome activation.
<\/a>Cao R, Ma Y, Li S, Shen D, Yang S, Wang X, Cao Y, Wang Z, Wei Y, Li S, Liu G, Zhang H, Wang Y, Ma Y.
J Leukoc Biol. 2020 Apr 1. doi: 10.1002\/JLB.3MA0320-406RR. [Epub ahead of print]<\/p>\n

Calcitriol Prevents Neuroinflammation and Reduces Blood-Brain Barrier Disruption and Local Macrophage\/Microglia Activation.
<\/a>de Oliveira LRC, Mimura LAN, Fraga-Silva TFC, Ishikawa LLW, Fernandes AAH, Zorzella-Pezavento SFG, Sartori A.
Front Pharmacol. 2020 Mar 12;11:161. doi: 10.3389\/fphar.2020.00161. eCollection 2020.<\/p>\n

Vitamin D<\/strong>\u00a0Receptor Inhibits\u00a0NLRP3<\/strong>\u00a0Activation by Impeding Its BRCC3-Mediated Deubiquitination.
<\/a>Rao Z, Chen X, Wu J, Xiao M, Zhang J, Wang B, Fang L, Zhang H, Wang X, Yang S, Chen Y.
Front Immunol. 2019 Dec 4;10:2783. doi: 10.3389\/fimmu.2019.02783. eCollection 2019.<\/p>\n

Toxicity of cooking oil fume derived particulate matter:\u00a0Vitamin D<\/strong>3<\/sub>\u00a0protects tubule formation activation in human umbilical vein endothelial cells.
<\/a>Ding L, Sui X, Yang M, Zhang Q, Sun S, Zhu F, Cheng H, Zhang C, Chen H, Ding R, Cao J.
Ecotoxicol Environ Saf. 2020 Jan 30;188:109905. doi: 10.1016\/j.ecoenv.2019.109905. Epub 2019 Nov 6.<\/p>\n

Effects of 1,25-dihydroxyvitamin D3 on experimental periodontitis and AhR\/NF-\u03baB\/NLRP3<\/strong>inflammasome pathway in a mouse model.
<\/a>Li H, Zhong X, Li W, Wang Q.
J Appl Oral Sci. 2019 Nov 4;27:e20180713. doi: 10.1590\/1678-7757-2018-0713. eCollection 2019.<\/p>\n

Vitamin D<\/strong>\u00a0insufficiency increases risk of chronic pain among African Americans experiencing motor vehicle collision.
<\/a>Mauck MC, Linnstaedt SD, Bortsov A, Kurz M, Hendry PL, Lewandowski C, Velilla MA, Datner E, Pearson C, Domeier R, Fillingim RB, Beaudoin FL, Ting JP, McLean SA.
Pain. 2020 Feb;161(2):274-280. doi: 10.1097\/j.pain.0000000000001728.<\/p>\n

Calcitriol inhibits ROS-NLRP3<\/strong>-IL-1\u03b2 signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells.
<\/a>Dai Y, Zhang J, Xiang J, Li Y, Wu D, Xu J.
Redox Biol. 2019 Feb;21:101093. doi: 10.1016\/j.redox.2018.101093. Epub 2018 Dec 26.<\/p>\n

1,25-Dihydroxy\u00a0Vitamin D<\/strong>3<\/sub>\u00a0Attenuates the Oxidative Stress-Mediated Inflammation Induced by PM2.5<\/sub>via the p38\/NF-\u03baB\/NLRP3<\/strong>\u00a0Pathway.
<\/a>Xin L, Che B, Zhai B, Luo Q, Zhang C, Wang J, Wang S, Fan G, Liu Z, Feng J, Zhang Z.
Inflammation. 2019 Apr;42(2):702-713. doi: 10.1007\/s10753-018-0928-y.<\/span><\/p>\n

Paricalcitol attenuates TGF-\u03b21-induced phenotype transition of human peritoneal mesothelial cells (HPMCs) via modulation of oxidative stress and\u00a0NLRP3<\/strong>\u00a0inflammasome.
<\/a>Ko J, Kang HJ, Kim DA, Ryu ES, Yu M, Lee H, Lee HK, Ryu HM, Park SH, Kim YL, Kang DH.
<\/span>FASEB J. 2019 Feb;33(2):3035-3050. doi: 10.1096\/fj.201800292RR. Epub 2018 Oct 24.<\/span><\/p>\n

Vitamin D<\/strong>\u00a0receptor interacts with\u00a0NLRP3<\/strong>\u00a0to restrict the allergic response.
<\/a>Huang H, Hong JY, Wu YJ, Wang EY, Liu ZQ, Cheng BH, Mei L, Liu ZG, Yang PC, Zheng PY.
<\/span>Clin Exp Immunol. 2018 Oct;194(1):17-26. doi: 10.1111\/cei.13164. Epub 2018 Sep 9.<\/span><\/p>\n

Vitamin D<\/strong>3<\/sub>\u00a0Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROS\/TXNIP\/NLRP3<\/strong>\u00a0Inflammasome Pathway.
<\/a>Lu L, Lu Q, Chen W, Li J, Li C, Zheng Z.
<\/span>J Diabetes Res. 2018 Feb 22;2018:8193523. doi: 10.1155\/2018\/8193523. eCollection 2018.<\/span><\/p>\n

The Effects of Varying Degree of MWCNT Carboxylation on Bioactivity in Various In Vivo and In Vitro Exposure Models.
<\/a>Hamilton RF, Wu Z, Mitra S, Holian A.
<\/span>Int J Mol Sci. 2018 Jan 25;19(2). pii: E354. doi: 10.3390\/ijms19020354.<\/span><\/p>\n

Vitamin D3 levels and\u00a0NLRP3<\/strong>\u00a0expression in murine models of obese asthma: association with asthma outcomes.
<\/a>Zhang JH, Chen YP, Yang X, Li CQ.
<\/span>Braz J Med Biol Res. 2017 Nov 13;51(1):e6841. doi: 10.1590\/1414-431X20176841.<\/span><\/p>\n

Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome.
<\/a>Ali NS, Sartori-Valinotti JC, Bruce AJ.
<\/span>Clin Dermatol. 2016 Jul-Aug;34(4):482-6. doi: 10.1016\/j.clindermatol.2016.02.021. Epub 2016 Mar 2. Review.<\/span><\/p>\n

Phenylbutyrate Is Bacteriostatic against Mycobacterium tuberculosis and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D3.
<\/a>Coussens AK, Wilkinson RJ, Martineau AR.
<\/span>PLoS Pathog. 2015 Jul 2;11(7):e1005007. doi: 10.1371\/journal.ppat.1005007. eCollection 2015 Jul.<\/span><\/p>\n

Resveratrol alleviates vascular inflammatory injury by inhibiting inflammasome activation in rats with hypercholesterolemia and vitamin D2 treatment.
<\/a>Deng ZY, Hu MM, Xin YF, Gang C.
<\/span>Inflamm Res. 2015 May;64(5):321-32. doi: 10.1007\/s00011-015-0810-4. Epub 2015 Apr 2.<\/span><\/p>\n

Vitamin D<\/strong>\u2083 metabolites enhance the\u00a0NLRP3<\/strong>-dependent secretion of IL-1\u03b2 from human THP-1 monocytic cells.
<\/a>Tulk SE, Liao KC, Muruve DA, Li Y, Beck PL, MacDonald JA.
<\/span>J Cell Biochem. 2015 May;116(5):711-20. doi: 10.1002\/jcb.24985.<\/span><\/p>\n

Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis.
<\/a>Peelen E, Damoiseaux J, Muris AH, Knippenberg S, Smolders J, Hupperts R, Thewissen M.
<\/span>Mol Immunol. 2015 Feb;63(2):521-9.<\/span><\/p>\n

Vitamin D<\/strong>\u00a0induces interleukin-1\u03b2 expression: paracrine macrophage epithelial signaling controls M. tuberculosis infection.
<\/a>Verway M, Bouttier M, Wang TT, Carrier M, Calderon M, An BS, Devemy E, McIntosh F, Divangahi M, Behr MA, White JH.
<\/span>PLoS Pathog. 2013;9(6):e1003407. doi: 10.1371\/journal.ppat.1003407. Epub 2013 Jun 6.<\/span><\/p>\n

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<\/h4>\n

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