{"id":1072,"date":"2020-04-11T23:10:39","date_gmt":"2020-04-11T23:10:39","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=1072"},"modified":"2020-04-11T23:13:02","modified_gmt":"2020-04-11T23:13:02","slug":"hydroxychloroquine-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/hydroxychloroquine-and-nlrp3\/","title":{"rendered":"Hydroxychloroquine and NLRP3"},"content":{"rendered":"

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Hydroxychloroquine and NLRP3<\/p>\n

<\/o:p><\/span><\/u><\/b><\/h4>\n

Lysosomotropic drugs enhance pro-inflammatory responses to IL-1\u03b2 in macrophages by inhibiting internalization of the IL-1 receptor.
<\/a>L\u00fcbow C, Bockstiegel J, Weindl G.
Biochem Pharmacol. 2020 Feb 20;175:113864. doi: 10.1016\/j.bcp.2020.113864. [Epub ahead of print]<\/p>\n

Hydroxychloroquine<\/strong>\u00a0inhibits IL-1\u03b2 production from amyloid-stimulated human neutrophils.
<\/a>Fujita Y, Matsuoka N, Temmoku J, Furuya MY, Asano T, Sato S, Kobayashi H, Watanabe H, Suzuki E, Urano T, Kozuru H, Yatsuhashi H, Koga T, Kawakami A, Migita K.
Arthritis Res Ther. 2019 Nov 27;21(1):250. doi: 10.1186\/s13075-019-2040-6.<\/p>\n

Prevention of crystalline silica-induced inflammation by the anti-malarial\u00a0hydroxychloroquine<\/strong>.
<\/a>Burmeister R, Rhoderick JF, Holian A.
Inhal Toxicol. 2019 Jun;31(7):274-284. doi: 10.1080\/08958378.2019.1668091. Epub 2019 Sep 26.<\/p>\n

Renoprotective effects of artemisinin and\u00a0hydroxychloroquine<\/strong>\u00a0combination therapy on IgA nephropathy via suppressing NF-\u03baB signaling and\u00a0NLRP3<\/strong>\u00a0inflammasome activation by exosomes in rats.
<\/a>Bai L, Li J, Li H, Song J, Zhou Y, Lu R, Liu B, Pang Y, Zhang P, Chen J, Liu X, Wu J, Liang C, Zhou J.
Biochem Pharmacol. 2019 Nov;169:113619. doi: 10.1016\/j.bcp.2019.08.021. Epub 2019 Aug 26.<\/p>\n

Hydroxychloroquine<\/strong>\u00a0attenuates renal ischemia\/reperfusion injury by inhibiting cathepsin mediated\u00a0NLRP3<\/strong>\u00a0inflammasome activation.
<\/a>Tang TT, Lv LL, Pan MM, Wen Y, Wang B, Li ZL, Wu M, Wang FM, Crowley SD, Liu BC.
Cell Death Dis. 2018 Mar 2;9(3):351. doi: 10.1038\/s41419-018-0378-3.<\/p>\n

Pro-inflammatory Ca++<\/sub>-activated K+<\/sub>\u00a0channels are inhibited by\u00a0hydroxychloroquine<\/strong>.
<\/a>Eugenia Schroeder M, Russo S, Costa C, Hori J, Tiscornia I, Bollati-Fogol\u00edn M, Zamboni DS, Ferreira G, Cairoli E, Hill M.
Sci Rep. 2017 May 15;7(1):1892. doi: 10.1038\/s41598-017-01836-8.<\/p>\n

Chorea in a patient with cryopyrin-associated periodic syndrome.
<\/a>Schwarzbach CJ, Schmitt WH, Szabo K, B\u00e4zner H, Hennerici MG, Blahak C.
Neurology. 2016 Jan 19;86(3):241-4. doi: 10.1212\/WNL.0000000000002300. Epub 2015 Dec 18.<\/p>\n

Anti-inflammatory therapies for cardiovascular disease.
<\/a>Ridker PM, L\u00fcscher TF.
Eur Heart J. 2014 Jul 14;35(27):1782-91. doi: 10.1093\/eurheartj\/ehu203. Epub 2014 May 26. Review.<\/p>\n

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[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″] Hydroxychloroquine and NLRP3 Lysosomotropic drugs enhance pro-inflammatory responses to IL-1\u03b2 in macrophages by inhibiting internalization of the IL-1 receptor.L\u00fcbow C, Bockstiegel […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1072"}],"collection":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/comments?post=1072"}],"version-history":[{"count":3,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1072\/revisions"}],"predecessor-version":[{"id":1076,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1072\/revisions\/1076"}],"wp:attachment":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/media?parent=1072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}