{"id":1066,"date":"2020-04-11T23:04:56","date_gmt":"2020-04-11T23:04:56","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=1066"},"modified":"2020-04-11T23:08:11","modified_gmt":"2020-04-11T23:08:11","slug":"azithromycin-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/azithromycin-and-nlrp3\/","title":{"rendered":"Azithromycin and NLRP3"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;3.19.3&#8243; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg&#8221; custom_padding=&#8221;0px|0px|0|0px|false|false&#8221;][et_pb_fullwidth_header title=&#8221;Are You CovidMune?&#x2122;&#8221; text_orientation=&#8221;center&#8221; _builder_version=&#8221;3.19.3&#8243; title_level=&#8221;h2&#8243; title_font=&#8221;|800|||on|||#e02b20|&#8221; title_text_color=&#8221;#ffffff&#8221; content_font=&#8221;|700|||||||&#8221; content_text_color=&#8221;#000000&#8243; subhead_font=&#8221;||||on|||#e02b20|&#8221; subhead_text_color=&#8221;#ffffff&#8221; subhead_font_size=&#8221;30px&#8221; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg&#8221; custom_button_one=&#8221;on&#8221; button_one_text_color=&#8221;#ffffff&#8221; button_one_border_color=&#8221;#e02b20&#8243; button_one_font=&#8221;|600|||||||&#8221; box_shadow_style_button_one=&#8221;preset2&#8243;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.19.3&#8243; custom_padding=&#8221;7px|0px|0|0px|false|false&#8221;][et_pb_row _builder_version=&#8221;3.19.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.19.3&#8243; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221;][et_pb_text _builder_version=&#8221;3.19.3&#8243;]<\/p>\n<h4 class=\"details\" align=\"center\"><b><u><span>Azithromycin and NLRP3<o:p><\/o:p><\/span><\/u><\/b><\/h4>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30422895\">New insights in neutrophilic asthma.<br \/><\/a>Seys SF, Lokwani R, Simpson JL, Bullens DMA.<br \/>Curr Opin Pulm Med. 2019 Jan;25(1):113-120. doi: 10.1097\/MCP.0000000000000543. Review.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28684545\">Macrolides protect against\u00a0<em>Pseudomonas aeruginosa<\/em>\u00a0infection via inhibition of inflammasomes.<br \/><\/a>Fan LC, Lin JL, Yang JW, Mao B, Lu HW, Ge BX, Choi AMK, Xu JF.<br \/>Am J Physiol Lung Cell Mol Physiol. 2017 Oct 1;313(4):L677-L686. doi: 10.1152\/ajplung.00123.2017. Epub 2017 Jul 6.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28659178\"><strong>Azithromycin<\/strong>\u00a0decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation.<br \/><\/a>Lendermon EA, Coon TA, Bednash JS, Weathington NM, McDyer JF, Mallampalli RK.<br \/>Respir Res. 2017 Jun 28;18(1):131. doi: 10.1186\/s12931-017-0608-8.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28258107\">Nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases.<br \/><\/a>Hodge S, Tran HB, Hamon R, Roscioli E, Hodge G, Jersmann H, Ween M, Reynolds PN, Yeung A, Treiberg J, Wilbert S.<br \/>Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L678-L687. doi: 10.1152\/ajplung.00518.2016. Epub 2017 Mar 3.<\/p>\n<p class=\"Title1\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<h4 style=\"text-align: center;\"><\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;3.19.3&#8243; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg&#8221; custom_padding=&#8221;0px|0px|0|0px|false|false&#8221;][et_pb_fullwidth_header title=&#8221;Are You CovidMune?&#x2122;&#8221; text_orientation=&#8221;center&#8221; _builder_version=&#8221;3.19.3&#8243; title_level=&#8221;h2&#8243; title_font=&#8221;|800|||on|||#e02b20|&#8221; title_text_color=&#8221;#ffffff&#8221; content_font=&#8221;|700|||||||&#8221; content_text_color=&#8221;#000000&#8243; subhead_font=&#8221;||||on|||#e02b20|&#8221; subhead_text_color=&#8221;#ffffff&#8221; subhead_font_size=&#8221;30px&#8221; background_image=&#8221;https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg&#8221; custom_button_one=&#8221;on&#8221; button_one_text_color=&#8221;#ffffff&#8221; button_one_border_color=&#8221;#e02b20&#8243; button_one_font=&#8221;|600|||||||&#8221; box_shadow_style_button_one=&#8221;preset2&#8243;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.19.3&#8243; custom_padding=&#8221;7px|0px|0|0px|false|false&#8221;][et_pb_row _builder_version=&#8221;3.19.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.19.3&#8243; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221;][et_pb_text _builder_version=&#8221;3.19.3&#8243;] Azithromycin and NLRP3 New insights in neutrophilic asthma.Seys SF, Lokwani R, Simpson JL, Bullens DMA.Curr Opin Pulm Med. 2019 Jan;25(1):113-120. doi: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1066"}],"collection":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/comments?post=1066"}],"version-history":[{"count":3,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1066\/revisions"}],"predecessor-version":[{"id":1070,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1066\/revisions\/1070"}],"wp:attachment":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/media?parent=1066"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}