{"id":1060,"date":"2020-04-11T22:57:50","date_gmt":"2020-04-11T22:57:50","guid":{"rendered":"https:\/\/areyoucovidmune.com\/covidmune\/?page_id=1060"},"modified":"2020-04-11T23:03:23","modified_gmt":"2020-04-11T23:03:23","slug":"chloroquine-and-nlrp3","status":"publish","type":"page","link":"https:\/\/areyoucovidmune.com\/covidmune\/chloroquine-and-nlrp3\/","title":{"rendered":"Chloroquine and NLRP3"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″]<\/p>\n

<\/h4>\n

Chloroquine and NLRP3<\/strong><\/span><\/h4>\n

Lysosomotropic drugs enhance pro-inflammatory responses to IL-1\u03b2 in macrophages by inhibiting internalization of the IL-1 receptor.
<\/a>L\u00fcbow C, Bockstiegel J, Weindl G.
Biochem Pharmacol. 2020 Feb 20;175:113864. doi: 10.1016\/j.bcp.2020.113864. [Epub ahead of print]<\/p>\n

Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
<\/a>Wang R, Zhu Y, Ren C, Yang S, Tian S, Chen H, Jin M, Zhou H.
Autophagy. 2020 Feb 11:1-16. doi: 10.1080\/15548627.2020.1725375. [Epub ahead of print]<\/p>\n

URB597 protects against\u00a0NLRP3<\/strong>\u00a0inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion.
<\/a>Su SH, Wu YF, Lin Q, Wang DP, Hai J.
J Neuroinflammation. 2019 Dec 9;16(1):260. doi: 10.1186\/s12974-019-1668-0.<\/p>\n

Prevention of crystalline silica-induced inflammation by the anti-malarial hydroxychloroquine.
<\/a>Burmeister R, Rhoderick JF, Holian A.
Inhal Toxicol. 2019 Jun;31(7):274-284. doi: 10.1080\/08958378.2019.1668091. Epub 2019 Sep 26.<\/p>\n

Mitophagy protects against acetaminophen-induced acute liver injury in mice through inhibiting\u00a0NLRP3<\/strong>inflammasome activation.
<\/a>Shan S, Shen Z, Zhang C, Kou R, Xie K, Song F.
<\/span>Biochem Pharmacol. 2019 Nov;169:113643. doi: 10.1016\/j.bcp.2019.113643. Epub 2019 Sep 19.<\/span><\/p>\n

Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice.
<\/a>Geng J, Liu J, Yuan X, Liu W, Guo W.
<\/span>Toxicol Appl Pharmacol. 2019 Sep 15;379:114688. doi: 10.1016\/j.taap.2019.114688. Epub 2019 Jul 21.<\/span><\/p>\n

Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1\u03b2 Expression in Primary Mouse Cardiac Fibroblasts.
<\/a>Torp MK, Yang K, Ranheim T, Hus\u00f8 Lauritzen K, Alfsnes K, Vinge LE, Aukrust P, Stensl\u00f8kken KO, Yndestad A, Sandanger \u00d8.
<\/span>Front Immunol. 2019 Jun 6;10:1285. doi: 10.3389\/fimmu.2019.01285. eCollection 2019.<\/span><\/p>\n

Small molecule-driven\u00a0NLRP3<\/strong>\u00a0inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.
<\/a>Han X, Sun S, Sun Y, Song Q, Zhu J, Song N, Chen M, Sun T, Xia M, Ding J, Lu M, Yao H, Hu G.
<\/span>Autophagy. 2019 Nov;15(11):1860-1881. doi: 10.1080\/15548627.2019.1596481. Epub 2019 Apr 9.<\/span><\/p>\n

[Trimetazidine reduces cholesterol content of foam cells by up-regulating autophagy and macrophage extracellular traps, and inhibiting inflammasome].
<\/a>Li Y, Hou W, Li T, Zhao J.
<\/span>Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018 Nov;34(11):969-976. Chinese.\u00a0<\/span><\/p>\n

Protective Role of Autophagy in\u00a0Nlrp3<\/strong>\u00a0Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries.
<\/a>Yuan X, Bhat OM, Meng N, Lohner H, Li PL.
<\/span>Am J Pathol. 2018 Dec;188(12):2948-2959. doi: 10.1016\/j.ajpath.2018.08.014. Epub 2018 Sep 29.<\/span><\/p>\n

Hydroxychloroquine attenuates renal ischemia\/reperfusion injury by inhibiting cathepsin mediated\u00a0NLRP3<\/strong>\u00a0inflammasome activation.
<\/a>Tang TT, Lv LL, Pan MM, Wen Y, Wang B, Li ZL, Wu M, Wang FM, Crowley SD, Liu BC.
<\/span>Cell Death Dis. 2018 Mar 2;9(3):351. doi: 10.1038\/s41419-018-0378-3.<\/span><\/p>\n

Pro-inflammatory Ca++<\/sub>-activated K+<\/sub>\u00a0channels are inhibited by hydroxychloroquine.
<\/a>Eugenia Schroeder M, Russo S, Costa C, Hori J, Tiscornia I, Bollati-Fogol\u00edn M, Zamboni DS, Ferreira G, Cairoli E, Hill M.
<\/span>Sci Rep. 2017 May 15;7(1):1892. doi: 10.1038\/s41598-017-01836-8.<\/span><\/p>\n

The Antimalarial\u00a0Chloroquine<\/strong>\u00a0Suppresses LPS-Induced\u00a0NLRP3<\/strong>\u00a0Inflammasome Activation and Confers Protection against Murine Endotoxic Shock.
<\/a>Chen X, Wang N, Zhu Y, Lu Y, Liu X, Zheng J.
<\/span>Mediators Inflamm. 2017;2017:6543237. doi: 10.1155\/2017\/6543237. Epub 2017 Feb 22.<\/span><\/p>\n

Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and\u00a0NLRP3<\/strong>-Inflammasome Activation in HepG2 Cells Is Size-Dependent.
<\/a>Mishra AR, Zheng J, Tang X, Goering PL.
<\/span>Toxicol Sci. 2016 Apr;150(2):473-87. doi: 10.1093\/toxsci\/kfw011. Epub 2016 Jan 21.<\/span><\/p>\n

Anti-inflammatory therapies for cardiovascular disease.
<\/a>Ridker PM, L\u00fcscher TF.
<\/span>Eur Heart J. 2014 Jul 14;35(27):1782-91. doi: 10.1093\/eurheartj\/ehu203. Epub 2014 May 26. Review.<\/span><\/p>\n

Sodium overload and water influx activate the NALP3 inflammasome.
<\/a>Schorn C, Frey B, Lauber K, Janko C, Strysio M, Keppeler H, Gaipl US, Voll RE, Springer E, Munoz LE, Schett G, Herrmann M.
<\/span>J Biol Chem. 2011 Jan 7;286(1):35-41. doi: 10.1074\/jbc.M110.139048. Epub 2010 Nov 4.<\/span><\/p>\n

SNP-guided microRNA maps (MirMaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways.
<\/a>Glinsky GV.
<\/span>Cell Cycle. 2008 Nov 15;7(22):3564-76. Epub 2008 Nov 26.<\/span><\/p>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″] Chloroquine and NLRP3 Lysosomotropic drugs enhance pro-inflammatory responses to IL-1\u03b2 in macrophages by inhibiting internalization of the IL-1 receptor.L\u00fcbow C, Bockstiegel […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1060"}],"collection":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/comments?post=1060"}],"version-history":[{"count":3,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1060\/revisions"}],"predecessor-version":[{"id":1064,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1060\/revisions\/1064"}],"wp:attachment":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/media?parent=1060"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}