Clinical Trial of NanoStilbene™️ for Immune Derepression in Advanced Cancer<\/strong><\/span><\/h4>\n\n<\/div>\n<\/div>\n\u00a0Pterostilbene, being a methyl ether of resveratrol, is known to possess anti-inflammatory and anticancer activity in various model systems.<\/span>\u00a0 <\/span>It is known that in advanced cancer, excess inflammatory signaling may be associated with <\/span>reduction<\/g> in CD3 zeta chain signaling and inhibited <\/span>function<\/g> of natural killer (NK) cells.<\/span><\/p>\nGiven the importance of NK cells in the activity of various Immunotherapeutics, we sought to determine whether administration of a nanoparticle formulation of pterostilbene may reverse cancer associated suppression of NK activity.\u00a0 <\/span>An initial study in heathy<\/g> volunteers was performed to elucidate amount<\/g> of NanoStilbene needed to be administered to achieve sufficient plasma concentration for induction of anti-inflammatory activity.<\/p>\nSubsequent to this, the selected NanoStilbene dose was administered to twelve patients with advanced solid cancers for 3 weeks.\u00a0 <\/span>Daily treatment with 300mgl of NanoStilbene caused reduction<\/g> in serum levels of inflammatory markers TNF-alpha, IL-6, and CRP.\u00a0 <\/span>Assessment of peripheral blood mononuclear cell ability to generate IFN-gamma subsequent to stimulation with anti-CD3 and anti-CD28 was increased.<\/p>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n\n12 patients with advanced cancer<\/span><\/strong><\/p>\n\n- ECOG >2<\/li>\n
- 300mg NanoStilbene Oral daily (300mg PTER)<\/li>\n
- Assessments pre and 1, 2, and 3 weeks after treatment<\/li>\n<\/ul>\n
Inflammatory Markers Decreased<\/span><\/strong><\/p>\n\n- TNF, IL-6, CRP<\/li>\n<\/ul>\n
Immune Markers Increased<\/span><\/strong><\/p>\n\n- IFN gamma from stimulated PBMC<\/li>\n
- NK Cytolysis activity<\/li>\n<\/ul>\n
<\/p>\n<\/div>\n<\/div>\n<\/div>\n
\n![\"\"](\"https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/12\/patients-1080x655-1.jpg\")
<\/span><\/div>\n<\/div>\n<\/div>\n\n\n\n\nTNF-a what is it?<\/strong>
Tumour Necrosis Factor alpha<\/strong> (TNF alpha<\/strong>), is an inflammatory cytokine produced by macrophages\/monocytes during acute inflammation and is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. The protein is also important for resistance to infection and cancers.<\/p>\nTNF inhibitors are drugs that help stop inflammation. They\u2019re used to treat diseases like rheumatoid arthritis (RA), juvenile arthritis, psoriatic arthritis, plaque psoriasis, ankylosing spondylitis, ulcerative colitis (UC), and Crohn\u2019s disease. They\u2019re also called TNF blockers, biologic therapies, or anti-TNF drugs.<\/p>\n<\/div>\n<\/div>\n
![\"\"](\"https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/12\/tnf-wk3-bct.jpg\")
<\/span><\/div>\n\n\nIL-6 what is it?<\/strong>
IL-6<\/strong> or Interleukin 6<\/strong>, is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation.<\/p>\nInterleukin inhibitors are immunosuppressive agents which inhibit the action of interleukins. Interleukins are a group of cytokines which are synthesized by lymphocytes, monocytes, macrophages, and certain other cells. They function especially in the regulation of the immune system.<\/p>\n<\/div>\n<\/div>\n
![\"\"](\"https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/12\/il6-wk3-bct.jpg\")
<\/span><\/div>\n\n\nCRP what is it?<\/strong>
CRP<\/strong> or C-reactive Protein<\/strong> is an annular, pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells.<\/p>\nLowering of CRP may be seen with the use of statin drugs even without significant improvement of the cholesterol profile. Reduction of CRP level has also been noted in individuals with known cardiovascular disease who begin aspirin therapy.<\/p>\n<\/div>\n<\/div>\n
![\"\"](\"https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/12\/crp-wk3-bct.jpg\")
<\/span><\/div>\n\n\nIFN-gamma what is it?<\/strong><\/p>\nIFN-gamma<\/strong>(IFN<\/span>\u03b3<\/span>)<\/span>,\u00a0<\/span><\/span>or type II interferon<\/span>, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoal infections. IFN<\/span>\u03b3 <\/span>is an important activator of macrophages and inducer of Class II major histocompatibility complex (MHC) molecule expression.<\/span><\/p>\nIFN<\/span>\u2013<\/span>gamma<\/span>\u00a0has long been recognized as a signature proinflammatory cytokine that plays a central role in\u00a0<\/span>inflammation<\/span>\u00a0and autoimmune disease. There is now emerging evidence indicating that\u00a0<\/span>IFN<\/span>\u2013<\/span>gamma<\/span>\u00a0possesses unexpected properties as a master regulator of immune responses and\u00a0<\/span>inflammation<\/span>.<\/span><\/p>\n<\/div>\n<\/div>\n![\"\"](\"https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/12\/ifn-wk3-bct.jpg\")
<\/span><\/div>\n\n\nNK cell what is it?<\/strong>
Natural killer cells<\/strong> (also known as NK cells<\/strong>, K cells<\/strong>, and killer cells<\/strong>) are a type of lymphocyte (a white blood cell) and a component of the innate immune system. NK cells play a major role in the host-rejection of both tumors and virally infected cells.<\/p>\nNK cells are activated in response to interferons or macrophage-derived cytokines. They serve to contain viral infections while the adaptive immune response generates antigen-specific cytotoxic T cells that can clear the infection. NK cells work to control viral infections by secreting IFN\u03b3 and TNF\u03b1.<\/p>\n<\/div>\n<\/div>\n
![\"\"](\"https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/12\/nk-wk3-bct.jpg\")
<\/span><\/div>\n\n\nAdditionally, NK cytotoxicity was augmented. These results suggest that NanoStilbene may be a useful adjuvant to immunotherapy of cancer rescuing T cell and NK cell activities.<\/p>\n
Augmentation of NK cell function may stimulate efficacy of approved therapies that depend on an active NK compartment such as Herceptin, Rituximab, and Cetuximab.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″] Clinical Trial of NanoStilbene™️ for Immune Derepression in Advanced Cancer \u00a0Pterostilbene, being a methyl ether of resveratrol, is known to possess […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1013"}],"collection":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/comments?post=1013"}],"version-history":[{"count":6,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1013\/revisions"}],"predecessor-version":[{"id":1021,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1013\/revisions\/1021"}],"wp:attachment":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/media?parent=1013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\u00a0Pterostilbene, being a methyl ether of resveratrol, is known to possess anti-inflammatory and anticancer activity in various model systems.<\/span>\u00a0 <\/span>It is known that in advanced cancer, excess inflammatory signaling may be associated with <\/span> Given the importance of NK cells in the activity of various Immunotherapeutics, we sought to determine whether administration of a nanoparticle formulation of pterostilbene may reverse cancer associated suppression of NK activity.\u00a0 <\/span>An initial study in Subsequent to this, the selected NanoStilbene dose was administered to twelve patients with advanced solid cancers for 3 weeks.\u00a0 <\/span>Daily treatment with 300mgl of NanoStilbene caused 12 patients with advanced cancer<\/span><\/strong><\/p>\n Inflammatory Markers Decreased<\/span><\/strong><\/p>\n Immune Markers Increased<\/span><\/strong><\/p>\n <\/p>\n<\/div>\n<\/div>\n<\/div>\n TNF-a what is it?<\/strong> TNF inhibitors are drugs that help stop inflammation. They\u2019re used to treat diseases like rheumatoid arthritis (RA), juvenile arthritis, psoriatic arthritis, plaque psoriasis, ankylosing spondylitis, ulcerative colitis (UC), and Crohn\u2019s disease. They\u2019re also called TNF blockers, biologic therapies, or anti-TNF drugs.<\/p>\n<\/div>\n<\/div>\n IL-6 what is it?<\/strong> Interleukin inhibitors are immunosuppressive agents which inhibit the action of interleukins. Interleukins are a group of cytokines which are synthesized by lymphocytes, monocytes, macrophages, and certain other cells. They function especially in the regulation of the immune system.<\/p>\n<\/div>\n<\/div>\n CRP what is it?<\/strong> Lowering of CRP may be seen with the use of statin drugs even without significant improvement of the cholesterol profile. Reduction of CRP level has also been noted in individuals with known cardiovascular disease who begin aspirin therapy.<\/p>\n<\/div>\n<\/div>\n IFN-gamma what is it?<\/strong><\/p>\n IFN-gamma<\/strong>(IFN<\/span>\u03b3<\/span>)<\/span>,\u00a0<\/span><\/span>or type II interferon<\/span>, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoal infections. IFN<\/span>\u03b3 <\/span>is an important activator of macrophages and inducer of Class II major histocompatibility complex (MHC) molecule expression.<\/span><\/p>\n IFN<\/span>\u2013<\/span>gamma<\/span>\u00a0has long been recognized as a signature proinflammatory cytokine that plays a central role in\u00a0<\/span>inflammation<\/span>\u00a0and autoimmune disease. There is now emerging evidence indicating that\u00a0<\/span>IFN<\/span>\u2013<\/span>gamma<\/span>\u00a0possesses unexpected properties as a master regulator of immune responses and\u00a0<\/span>inflammation<\/span>.<\/span><\/p>\n<\/div>\n<\/div>\n NK cell what is it?<\/strong> NK cells are activated in response to interferons or macrophage-derived cytokines. They serve to contain viral infections while the adaptive immune response generates antigen-specific cytotoxic T cells that can clear the infection. NK cells work to control viral infections by secreting IFN\u03b3 and TNF\u03b1.<\/p>\n<\/div>\n<\/div>\n Additionally, NK cytotoxicity was augmented. These results suggest that NanoStilbene may be a useful adjuvant to immunotherapy of cancer rescuing T cell and NK cell activities.<\/p>\n Augmentation of NK cell function may stimulate efficacy of approved therapies that depend on an active NK compartment such as Herceptin, Rituximab, and Cetuximab.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" [et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.3″ background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2019\/11\/shutterstock_112250879.jpg” custom_padding=”0px|0px|0|0px|false|false”][et_pb_fullwidth_header title=”Are You CovidMune?™” text_orientation=”center” _builder_version=”3.19.3″ title_level=”h2″ title_font=”|800|||on|||#e02b20|” title_text_color=”#ffffff” content_font=”|700|||||||” content_text_color=”#000000″ subhead_font=”||||on|||#e02b20|” subhead_text_color=”#ffffff” subhead_font_size=”30px” background_image=”https:\/\/areyoucovidmune.com\/covidmune\/wp-content\/uploads\/2020\/04\/covid-19-dna.jpg” custom_button_one=”on” button_one_text_color=”#ffffff” button_one_border_color=”#e02b20″ button_one_font=”|600|||||||” box_shadow_style_button_one=”preset2″][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.3″ custom_padding=”7px|0px|0|0px|false|false”][et_pb_row _builder_version=”3.19.3″][et_pb_column type=”4_4″ _builder_version=”3.19.3″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.3″] Clinical Trial of NanoStilbene™️ for Immune Derepression in Advanced Cancer \u00a0Pterostilbene, being a methyl ether of resveratrol, is known to possess […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":""},"_links":{"self":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1013"}],"collection":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/comments?post=1013"}],"version-history":[{"count":6,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1013\/revisions"}],"predecessor-version":[{"id":1021,"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/pages\/1013\/revisions\/1021"}],"wp:attachment":[{"href":"https:\/\/areyoucovidmune.com\/covidmune\/wp-json\/wp\/v2\/media?parent=1013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
\n
\n
<\/span><\/div>\n<\/div>\n<\/div>\n
Tumour Necrosis Factor alpha<\/strong> (TNF alpha<\/strong>), is an inflammatory cytokine produced by macrophages\/monocytes during acute inflammation and is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. The protein is also important for resistance to infection and cancers.<\/p>\n<\/span><\/div>\n
IL-6<\/strong> or Interleukin 6<\/strong>, is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation.<\/p>\n<\/span><\/div>\n
CRP<\/strong> or C-reactive Protein<\/strong> is an annular, pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells.<\/p>\n<\/span><\/div>\n<\/span><\/div>\n
Natural killer cells<\/strong> (also known as NK cells<\/strong>, K cells<\/strong>, and killer cells<\/strong>) are a type of lymphocyte (a white blood cell) and a component of the innate immune system. NK cells play a major role in the host-rejection of both tumors and virally infected cells.<\/p>\n<\/span><\/div>\n